UA115772C2 - Композиція програмованого нуклеопротеїнового молекулярного комплексу і спосіб модифікування заданої послідовності нуклеїнової кислоти-мішені - Google Patents
Композиція програмованого нуклеопротеїнового молекулярного комплексу і спосіб модифікування заданої послідовності нуклеїнової кислоти-мішеніInfo
- Publication number
- UA115772C2 UA115772C2 UAA201408005A UAA201408005A UA115772C2 UA 115772 C2 UA115772 C2 UA 115772C2 UA A201408005 A UAA201408005 A UA A201408005A UA A201408005 A UAA201408005 A UA A201408005A UA 115772 C2 UA115772 C2 UA 115772C2
- Authority
- UA
- Ukraine
- Prior art keywords
- nucleic acid
- acid sequence
- modifying
- target nucleic
- compositions
- Prior art date
Links
- 150000007523 nucleic acids Chemical group 0.000 title abstract 6
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000011931 Nucleoproteins Human genes 0.000 abstract 2
- 108010061100 Nucleoproteins Proteins 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N15/62—DNA sequences coding for fusion proteins
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- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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- C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
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- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract
Винахід стосується композиції програмованого нуклеопротеїнового молекулярного комплексу, який містить поліпептидний компонент і нуклеїнову кислоту, що надає специфічність (SCNA), який піддається самозбиранню in vivo, в клітині-мішені, і здатний до взаємодії із заданою послідовністю нуклеїнової кислоти-мішені. Винахід також стосується способу модифікування заданої послідовності нуклеїнової кислоти, клітин-хазяїв та трансгенних організмів із заданою генетичною модифікацією.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161576423P | 2011-12-16 | 2011-12-16 | |
PCT/IL2012/050528 WO2013088446A1 (en) | 2011-12-16 | 2012-12-16 | Compositions and methods for modifying a predetermined target nucleic acid sequence |
Publications (1)
Publication Number | Publication Date |
---|---|
UA115772C2 true UA115772C2 (uk) | 2017-12-26 |
Family
ID=48611953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201408005A UA115772C2 (uk) | 2011-12-16 | 2012-12-16 | Композиція програмованого нуклеопротеїнового молекулярного комплексу і спосіб модифікування заданої послідовності нуклеїнової кислоти-мішені |
Country Status (15)
Country | Link |
---|---|
US (5) | US11458157B2 (uk) |
EP (1) | EP2790708A4 (uk) |
JP (1) | JP2015500648A (uk) |
CN (1) | CN104080462B (uk) |
AU (2) | AU2012354062B2 (uk) |
BR (1) | BR112014014105B1 (uk) |
CA (2) | CA3226329A1 (uk) |
HK (1) | HK1203362A1 (uk) |
IL (2) | IL253373A0 (uk) |
IN (1) | IN2014MN00974A (uk) |
PH (1) | PH12014501360A1 (uk) |
RU (1) | RU2663354C2 (uk) |
UA (1) | UA115772C2 (uk) |
WO (1) | WO2013088446A1 (uk) |
ZA (1) | ZA201403785B (uk) |
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EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
UA116097C2 (uk) | 2011-12-11 | 2018-02-12 | Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре | Спосіб модуляції провідності устячка рослини |
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EP4339287A3 (en) | 2015-07-31 | 2024-05-22 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
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