EA201390145A1 - Конъюгаты, частицы, композиции и связанные с ними способы - Google Patents

Конъюгаты, частицы, композиции и связанные с ними способы

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Publication number
EA201390145A1
EA201390145A1 EA201390145A EA201390145A EA201390145A1 EA 201390145 A1 EA201390145 A1 EA 201390145A1 EA 201390145 A EA201390145 A EA 201390145A EA 201390145 A EA201390145 A EA 201390145A EA 201390145 A1 EA201390145 A1 EA 201390145A1
Authority
EA
Eurasian Patent Office
Prior art keywords
conjugates
particles
compositions
related methods
methods
Prior art date
Application number
EA201390145A
Other languages
English (en)
Inventor
Скотт Элиасоф
Оливер С. Фетцер
Дзунгйеон Хванг
Патрик Лим Соо
Пей-Сзе Нг
Зонке Свенсон
Дональд Э. Бергстром
Original Assignee
Серулин Фарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Серулин Фарма Инк. filed Critical Серулин Фарма Инк.
Publication of EA201390145A1 publication Critical patent/EA201390145A1/ru

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
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Abstract

Частицы и конъюгаты для доставки нуклеиновых кислот-агентов. Композиции, содержащие указанные частицы, конъюгаты или частицы и конъюгаты. Способы использования указанных частиц, конъюгатов и композиций.
EA201390145A 2010-08-20 2011-08-18 Конъюгаты, частицы, композиции и связанные с ними способы EA201390145A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37578310P 2010-08-20 2010-08-20
US38788210P 2010-09-29 2010-09-29
US201161443972P 2011-02-17 2011-02-17
US201161475923P 2011-04-15 2011-04-15
PCT/US2011/048305 WO2012024526A2 (en) 2010-08-20 2011-08-18 Conjugates, particles, compositions, and related methods

Publications (1)

Publication Number Publication Date
EA201390145A1 true EA201390145A1 (ru) 2013-11-29

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EA201390145A EA201390145A1 (ru) 2010-08-20 2011-08-18 Конъюгаты, частицы, композиции и связанные с ними способы

Country Status (10)

Country Link
US (4) US20120225129A1 (ru)
EP (1) EP2605799A4 (ru)
JP (1) JP5756858B2 (ru)
CN (1) CN103080313A (ru)
AU (1) AU2011291582A1 (ru)
BR (1) BR112013003825A2 (ru)
CA (1) CA2808901A1 (ru)
EA (1) EA201390145A1 (ru)
MX (1) MX2013002048A (ru)
WO (1) WO2012024526A2 (ru)

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