UA114936U - 5'-(4''-ізопропілфеніліден)спіро[3h-індол-3]-3'-4,2'-тіазолідинхлорфеніл-2,4'(1h)-діон, що проявляє селективну протипухлинну активність - Google Patents

5'-(4''-ізопропілфеніліден)спіро[3h-індол-3]-3'-4,2'-тіазолідинхлорфеніл-2,4'(1h)-діон, що проявляє селективну протипухлинну активність Download PDF

Info

Publication number: UA114936U
Authority: UA; Ukraine
Prior art keywords: cancer; indole; dione; tumor; isopropylphenylidene
Prior art date: 2016-10-12

Application number

UAU201610392U

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-10-12

Filing date

2016-10-12

Publication date

2017-03-27

2016-10-12 Application filed filed Critical

2016-10-12 Priority to UAU201610392U priority Critical patent/UA114936U/uk

2017-03-27 Publication of UA114936U publication Critical patent/UA114936U/uk

Links

230000000259 anti-tumor effect Effects 0.000 title description 6
229920004518 DION® Polymers 0.000 title 1
125000003003 spiro group Chemical group 0.000 claims abstract description 13
208000008839 Kidney Neoplasms Diseases 0.000 claims abstract description 9
206010038389 Renal cancer Diseases 0.000 claims abstract description 9
201000010982 kidney cancer Diseases 0.000 claims abstract description 9
208000032839 leukemia Diseases 0.000 claims abstract description 9
230000000694 effects Effects 0.000 claims abstract description 6
206010009944 Colon cancer Diseases 0.000 claims description 6
208000029742 colonic neoplasm Diseases 0.000 claims description 6
210000003734 kidney Anatomy 0.000 claims description 2
210000001072 colon Anatomy 0.000 abstract description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
150000001875 compounds Chemical class 0.000 description 11
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
206010028980 Neoplasm Diseases 0.000 description 6
239000002246 antineoplastic agent Substances 0.000 description 6
210000004027 cell Anatomy 0.000 description 6
239000003814 drug Substances 0.000 description 6
JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 6
230000001093 anti-cancer Effects 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 5
201000011510 cancer Diseases 0.000 description 5
229940079593 drug Drugs 0.000 description 5
238000003786 synthesis reaction Methods 0.000 description 5
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 4
WTWBUQJHJGUZCY-UHFFFAOYSA-N cuminaldehyde Chemical compound CC(C)C1=CC=C(C=O)C=C1 WTWBUQJHJGUZCY-UHFFFAOYSA-N 0.000 description 4
CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 4
YGDWUQFZMXWDKE-UHFFFAOYSA-N 1-oxido-1,3-thiazole Chemical group [O-]S1=CN=C=C1 YGDWUQFZMXWDKE-UHFFFAOYSA-N 0.000 description 3
206010006187 Breast cancer Diseases 0.000 description 3
208000026310 Breast neoplasm Diseases 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
206010033128 Ovarian cancer Diseases 0.000 description 3
206010061535 Ovarian neoplasm Diseases 0.000 description 3
239000000203 mixture Substances 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 2
239000013543 active substance Substances 0.000 description 2
229940041181 antineoplastic drug Drugs 0.000 description 2
208000016063 arterial thoracic outlet syndrome Diseases 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
229940044683 chemotherapy drug Drugs 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
229960004679 doxorubicin Drugs 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
230000003993 interaction Effects 0.000 description 2
201000001441 melanoma Diseases 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
206010000830 Acute leukaemia Diseases 0.000 description 1
BMTAFVWTTFSTOG-UHFFFAOYSA-N Butylate Chemical compound CCSC(=O)N(CC(C)C)CC(C)C BMTAFVWTTFSTOG-UHFFFAOYSA-N 0.000 description 1
206010048610 Cardiotoxicity Diseases 0.000 description 1
GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 description 1
239000002147 L01XE04 - Sunitinib Substances 0.000 description 1
206010025323 Lymphomas Diseases 0.000 description 1
206010060862 Prostate cancer Diseases 0.000 description 1
208000000236 Prostatic Neoplasms Diseases 0.000 description 1
208000005718 Stomach Neoplasms Diseases 0.000 description 1
240000003864 Ulex europaeus Species 0.000 description 1
229940045799 anthracyclines and related substance Drugs 0.000 description 1
230000001773 anti-convulsant effect Effects 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
230000000118 anti-neoplastic effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
239000001961 anticonvulsive agent Substances 0.000 description 1
229960003965 antiepileptics Drugs 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000003972 antineoplastic antibiotic Substances 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
201000008275 breast carcinoma Diseases 0.000 description 1
231100000259 cardiotoxicity Toxicity 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
201000007455 central nervous system cancer Diseases 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
235000019441 ethanol Nutrition 0.000 description 1
DQYBDCGIPTYXML-UHFFFAOYSA-N ethoxyethane;hydrate Chemical compound O.CCOCC DQYBDCGIPTYXML-UHFFFAOYSA-N 0.000 description 1
206010017758 gastric cancer Diseases 0.000 description 1
230000012010 growth Effects 0.000 description 1
150000002391 heterocyclic compounds Chemical class 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
201000005296 lung carcinoma Diseases 0.000 description 1
230000003039 myelosuppressive effect Effects 0.000 description 1
230000001613 neoplastic effect Effects 0.000 description 1
208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
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238000011197 physicochemical method Methods 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
238000012216 screening Methods 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
201000011549 stomach cancer Diseases 0.000 description 1
239000000126 substance Substances 0.000 description 1
229960001796 sunitinib Drugs 0.000 description 1
WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
230000004565 tumor cell growth Effects 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

UAU201610392U 2016-10-12 2016-10-12 5'-(4''-ізопропілфеніліден)спіро[3h-індол-3]-3'-4,2'-тіазолідинхлорфеніл-2,4'(1h)-діон, що проявляє селективну протипухлинну активність UA114936U (xx)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
UAU201610392U UA114936U (xx)	2016-10-12	2016-10-12	5'-(4''-ізопропілфеніліден)спіро[3h-індол-3]-3'-4,2'-тіазолідинхлорфеніл-2,4'(1h)-діон, що проявляє селективну протипухлинну активність

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
UAU201610392U UA114936U (xx)	2016-10-12	2016-10-12	5'-(4''-ізопропілфеніліден)спіро[3h-індол-3]-3'-4,2'-тіазолідинхлорфеніл-2,4'(1h)-діон, що проявляє селективну протипухлинну активність

Publications (1)

Publication Number	Publication Date
UA114936U true UA114936U (xx)	2017-03-27

Family

ID=58531293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAU201610392U UA114936U (xx)	2016-10-12	2016-10-12	5'-(4''-ізопропілфеніліден)спіро[3h-індол-3]-3'-4,2'-тіазолідинхлорфеніл-2,4'(1h)-діон, що проявляє селективну протипухлинну активність

Country Status (1)

Country	Link
UA (1)	UA114936U (xx)

2016
- 2016-10-12 UA UAU201610392U patent/UA114936U/uk unknown

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