TWM487084U - 包覆乳酸菌之微膠囊結構體 - Google Patents
包覆乳酸菌之微膠囊結構體 Download PDFInfo
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Description
本創作是有關於一種微膠囊結構體,特別是關於一種包覆乳酸菌之微膠囊結構體。
乳酸菌一般泛指利用碳水化合物進行發酵而產生乳酸的細菌,乳酸菌可改善宿主腸內微生物的平衡以促進人類或動物健康,因此被歸類為有益健康的益生菌(probiotics)。
乳酸菌或其代謝產物所製成的產品,包括乳酸飲料、優酪乳、整腸藥品、健康食品及動物飼料等。而乳酸菌常見的製劑型態為液體、膠囊、錠劑、粉末等,但於這些產品型態,乳酸菌容易受到自身代謝產物、外在環境的紫外光、高溫、水活性和氧氣等因素而逐漸失去活性,使乳酸菌無法完整的發揮保健效果。此外,當人體或動物攝食後,會受到消化系統中的胃酸及膽鹽傷害而嚴重影響乳酸菌的存活。因此,乳酸菌產品的製造劑型及包覆方法乃保護乳酸菌以維持其促進健康功能的關鍵。
現今市售乳酸菌的產品主要分成兩種型態,一種為液態優酪乳,另一種為粉末。液態產品必需放置於低溫冰箱中,且儲存時間較短,也不方便攜帶。粉末型態常製成膠囊或粉末造粒,雖然儲存時間相對於液態產品長,但卻容易吸濕受潮,而造成乳酸菌活性的快速降低。此外,無論液態或粉末的乳酸菌製劑若加工過程中施加壓力或高溫也會使乳酸菌活性降低,甚至完全喪失活性。根據研究發現,經良好技術所包覆的乳酸菌比無包覆的乳酸菌有更好的活性及更長的儲存期限。然而,現今技術對於粉末化乳酸菌的包覆方式,多為一般雙層包覆或三層包覆法,亦或凍晶包覆法,但這些製劑產品的活性仍會受到溫度、酸鹼的影響而降低活性,甚至無法達到適時適地的釋放包覆於其中之乳酸菌,而無法激活腸道細胞中的培氏斑(Peyer's patch)淋巴結組織。
為解決上述問題,本創作提供一種包覆乳酸菌之微膠囊結構體,用以保護乳酸菌完整到達小腸及大腸,並藉由抗體抗原辨識連結而精準的對抗入侵人體的腸病毒、病原菌以調節人體免疫之功能。
本創作之包覆乳酸菌之微膠囊結構體,包含核心層和殼層。核心層係含有乳酸菌,殼層具有細胞連結標靶反應層、耐胃酸層和耐膽鹽層,其中殼層係由外向內以細胞連結標靶反應層、耐胃酸層和耐膽鹽層包覆核心層。
根據本創作之第一實施方式,其中乳酸菌係選自於由Lactobacillus,Bifidobacterium,Streptococcus,Pediococcus,Leuconostoc
及Entercoccus
之菌屬所組成之一群組或上述菌屬之組合。
根據本創作之第二實施方式,其中核心層更包含營養因子和促進生長因子。營養因子包含維生素、左旋C、寡糖、藻精、礦物質、酵母萃取物、必需胺基酸和芝麻素。促進生長因子包含細胞生長蛋白(CGF)、Q10和靈芝免疫調節蛋白。
根據本創作之第三實施方式,其中細胞連結標靶反應層具有免疫原和多醣係用以調節體內之免疫功能。免疫原包含腸道免疫淋巴結之辨識抗原、腸病毒抗體和腸道病原菌之表現抗原。多醣包含松木多醣、靈芝多醣、樟芝多醣和蟲草多醣。
根據本創作之第四實施方式,其中耐胃酸層包含松木多醣、多元不飽和脂肪酸、酸性胺基酸、結蘭膠、海藻醣、脫脂奶粉、胚芽萃取物和洛神萃取物,用以保護乳酸菌不受胃酸傷害。
根據本創作之第五實施方式,其中耐膽鹽層包含膠原蛋白、魚油、多元不飽和脂肪酸、褐藻醣膠和鹼性胺基酸,用以保護乳酸菌不受膽鹽傷害。
藉此,本創作之包覆乳酸菌之微膠囊結構體,其核心層具有乳酸菌、各種營養因子和促進乳酸菌生長因子,營養因子和促進乳酸菌生長因子可加強乳酸菌之活性,並
延長乳酸菌於腸道之存活時間。而耐胃酸層和耐膽鹽層可使乳酸菌不易受外界環境而降低功能和活性。另細胞連結標靶反應層能抗腸病毒、病菌及調節人體免疫。
100‧‧‧包覆乳酸菌之微膠囊結構體
200‧‧‧殼層
210‧‧‧細胞連結標靶反應層
211‧‧‧免疫原
212‧‧‧多醣
220‧‧‧耐胃酸層
230‧‧‧耐膽鹽層
300‧‧‧核心層
310‧‧‧乳酸菌
320‧‧‧營養因子
330‧‧‧促進生長因子
第1圖繪示本創作之包覆乳酸菌之微膠囊結構體之示意圖。
請參照第1圖所示,係本創作之包覆乳酸菌之微膠囊結構體之示意圖,包覆乳酸菌之微膠囊結構體100,包含核心層300和殼層200。
核心層300係含有乳酸菌310、營養因子320和促進生長因子330。其中乳酸菌310為可利用碳水化合物產生乳酸等有機酸的各種乳酸菌310,核心層300之乳酸菌310可為下述單一菌種或複方多菌種混合,乳酸菌310係選自於由Lactobacillus,Bifidobacterium,Streptococcus,Pediococcus,Leuconostoc
及Entercoccus
之菌屬。例如:Lactobacillus acidophilus,Lactobacillus casei,Lactobacillus rhamnosus,Lactobacillus brevis,Lactobacillus paracasei,Lactobacillus delbrueckii、Lactobacillus bulgaricus,Lactobacillus buchneri,Lactobacillus helveticus,Lactobacillus fermentum,Lactobacillus plantarum,Bifidobacterium bifidum, Bifidobacterium breve,Bifidobacterium infantis,Bifidobacterium lactis,Bifidobacterium longum,Enterococcus faecalis,Enterococcus faecium,Streptococcus thermophilus,Pediococcus acidilactici,Pediococcus pentosaceus
或Leuconostoc mesenteroides
。營養因子320包含維生素、左旋C、寡糖、藻精、礦物質、酵母萃取物、必需胺基酸和芝麻素。促進生長因子330包含細胞生長蛋白(CGF)、Q10和靈芝免疫調節蛋白。營養因子320和促進生長因子330係用以加強乳酸菌310的活性,並延長乳酸菌310於腸道內之存活時間。
殼層200具有細胞連結標靶反應層210、耐胃酸層220和耐膽鹽層230,其中殼層200係由外向內以細胞連結標靶反應層210、耐胃酸層220和耐膽鹽層230包覆核心層300。
細胞連結標靶反應層210為包覆乳酸菌之微膠囊結構體100之最外層,細胞連結標靶反應層210表面組成最為特殊,具有免疫原211和多醣212。免疫原211包含腸道免疫淋巴結之辨識抗原、腸病毒抗體和腸道病原菌之表現抗原。多醣212包含松木多醣、靈芝多醣、樟芝多醣和蟲草多醣,係作為免疫加強佐劑以調節體內之免疫功能。
耐胃酸層220包含松木多醣、多元不飽和脂肪酸、酸性胺基酸、結蘭膠、海藻醣、脫脂奶粉、胚芽萃取物和洛神萃取物。耐膽鹽層230包含膠原蛋白、魚油、多元不飽和脂肪酸、褐藻醣膠和鹼性胺基酸。耐胃酸層220和耐
膽鹽層230係用以保護乳酸菌310不受人體或動物體之膽鹽及胃酸傷害,而完整到達小腸及大腸部位。
根據上述,本創作之包覆乳酸菌之微膠囊結構體100,核心層具有乳酸菌310、各種營養因子320和促進乳酸菌生長因子330,營養因子320和促進乳酸菌生長因子330可加強乳酸菌310之活性和延長乳酸菌310於腸道之存活時間。並具有耐胃酸層220和耐膽鹽層230可使乳酸菌310不易受外界環境而降低功能和活性。且具有細胞連結標靶反應層210,藉由抗體抗原辨識連結而精準的對抗入侵人體的腸病毒、病原菌以調節人體免疫。
雖然本創作已利用上述實施方式揭示,然其並非用以限定本創作,任何熟悉此技藝者在不脫離本創作之精神和範圍之內,相對上述實施例進行各種更動與修改仍屬本創作所保護之技術範疇,因此本創作之保護範圍當是後復之申請專利範圍所界定者為準。
100‧‧‧包覆乳酸菌之微膠囊結構體
200‧‧‧殼層
210‧‧‧細胞連結標靶反應層
211‧‧‧免疫原
212‧‧‧多醣
220‧‧‧耐胃酸層
230‧‧‧耐膽鹽層
300‧‧‧核心層
310‧‧‧乳酸菌
320‧‧‧營養因子
330‧‧‧促進生長因子
Claims (13)
- 一種包覆乳酸菌之微膠囊結構體,包含:一核心層,係含有一乳酸菌;以及一殼層,具有一細胞連結標靶反應層、一耐膽鹽層和一耐胃酸層,該殼層係由外向內以該細胞連結標靶反應層、該耐胃酸層和該耐膽鹽層包覆該核心層。
- 如請求項1所述之包覆乳酸菌之微膠囊結構體,其中該乳酸菌係選自於由Lactobacillus,Bifidobacterium,Streptococcus,Pediococcus,Leuconostoc 及Entercoccus 之菌屬所組成之一群組或上述菌屬之組合。
- 如請求項1所述之包覆乳酸菌之微膠囊結構體,其中該核心層更包含一營養因子和一促進生長因子。
- 如請求項3所述之包覆乳酸菌之微膠囊結構體,其中該營養因子包含維生素、左旋C、寡糖、藻精、礦物質、酵母萃取物、必需胺基酸和芝麻素。
- 如請求項3所述之包覆乳酸菌之微膠囊結構體,其中該促進生長因子包含細胞生長蛋白(CGF)、Q10和靈芝免疫調節蛋白。
- 如請求項1所述之包覆乳酸菌之微膠囊結構體,其中 該細胞連結標靶反應層具有一免疫原和一多醣。
- 如請求項6所述之包覆乳酸菌之微膠囊結構體,其中該免疫原包含腸道免疫淋巴結之辨識抗原、腸病毒抗體和腸道病原菌之表現抗原。
- 如請求項6所述之包覆乳酸菌之微膠囊結構體,其中該多醣包含松木多醣、靈芝多醣、樟芝多醣和蟲草多醣。
- 7或8所述之包覆乳酸菌之微膠囊結構體,其中該細胞連結標靶反應層係用以調節體內之免疫功能。
- 如請求項1所述之包覆乳酸菌之微膠囊結構體,其中該耐胃酸層包含松木多醣、多元不飽和脂肪酸、酸性胺基酸、結蘭膠、海藻醣、脫脂奶粉、胚芽萃取物和洛神萃取物。
- 如請求項10所述之包覆乳酸菌之微膠囊結構體,其中該耐胃酸層係用以保護乳酸菌不受胃酸傷害。
- 如請求項1所述之包覆乳酸菌之微膠囊結構體,其中該耐膽鹽層包含膠原蛋白、魚油、多元不飽和脂肪酸、褐藻醣膠和鹼性胺基酸。
- 如請求項12所述之包覆乳酸菌之微膠囊結構體,其中該耐膽鹽層係用以保護乳酸菌不受膽鹽傷害。
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105310080A (zh) * | 2015-10-26 | 2016-02-10 | 中山大学 | 益生菌微胶囊及其制备方法和应用 |
TWI587863B (zh) * | 2016-01-29 | 2017-06-21 | Grape King Inc | A probiotic entrapping particle |
CN113875986A (zh) * | 2020-07-01 | 2022-01-04 | 葡萄王生技股份有限公司 | 抗氧化多层包埋益生菌颗粒及其制造方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105310080A (zh) * | 2015-10-26 | 2016-02-10 | 中山大学 | 益生菌微胶囊及其制备方法和应用 |
CN105310080B (zh) * | 2015-10-26 | 2018-04-06 | 中山大学 | 益生菌微胶囊及其制备方法和应用 |
TWI587863B (zh) * | 2016-01-29 | 2017-06-21 | Grape King Inc | A probiotic entrapping particle |
CN113875986A (zh) * | 2020-07-01 | 2022-01-04 | 葡萄王生技股份有限公司 | 抗氧化多层包埋益生菌颗粒及其制造方法 |
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