TWI730286B - Preparation method and usage of oral composition - Google Patents
Preparation method and usage of oral composition Download PDFInfo
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本發明係關於一種口腔組合物的技術領域，尤指一種口腔用組合物及其製備方法與用途。 The present invention relates to the technical field of an oral composition, in particular to an oral composition and its preparation method and application.
按，人類牙齒結構中包含有三種礦化組織：琺瑯質、牙骨質和牙本質。琺瑯質覆蓋冠部牙本質，而牙骨質同時覆蓋在根部牙本質，其中，牙本質用來包覆血管和神經支撐物的牙髓，且牙本質具有許多橫穿的小管，不似於琺瑯質和牙骨質，牙本質小管壁由牙本質的鈣化基質所組成，且牙本質小管內部空隙充滿源自牙髓組織液和血清的液體(牙本質液)。 According to the theory, the structure of human teeth contains three types of mineralized tissues: enamel, cementum and dentin. Enamel covers the dentin of the crown, while cementum covers the dentin of the root at the same time. The dentin is used to coat the pulp of blood vessels and nerve supports, and the dentin has many small tubes that cross, unlike enamel and teeth. Bone and dentin tubules are composed of calcified matrix of dentin, and the internal voids of the dentin tubules are filled with fluid derived from pulp tissue fluid and serum (dentin fluid).
口腔內的細菌可以在牙齒表面形成生物膜，並能夠製造的酸性產物，所述酸性產物能夠侵蝕琺瑯質或牙骨質的結構，使得牙本質喪失琺瑯質或牙骨質的覆蓋而裸露在外，進而產生牙本質的過敏症狀。因此，相關業者研發口腔保健產品，比如售潄口水和牙膏，能夠清潔口腔內的細菌以及酸性產物，提供修復牙齒的結構。 Bacteria in the oral cavity can form a biofilm on the surface of the tooth and can produce acidic products that can erode the structure of enamel or cementum, so that dentin loses the coverage of enamel or cementum and is exposed to the outside, thereby producing dentin Symptoms of allergies. Therefore, related industries have developed oral health products, such as mouthwashes and toothpastes, which can clean the bacteria and acid products in the oral cavity and provide a structure for restoring teeth.
在此同時，通常牙膏成分中含有抗菌劑，如三氯沙(Triclosan)，具有抗菌防腐的功效；但是，三氯沙是一種***，長期使用會導致人體賀爾 蒙失調，而且含有三氯沙的牙膏與含氯的自來水接觸反應後，會產生致癌成分三氯甲烷(Chloroform)，容易被舌頭或是口腔黏膜吸收，進而累積在人體內產生致癌風險。 At the same time, usually toothpaste contains antibacterial agents, such as Triclosan, which has antibacterial and antiseptic effects; however, triclosan is an estrogen, and long-term use can cause human body If the toothpaste contains triclosan and reacts with chlorine-containing tap water, it will produce the carcinogenic component Chloroform, which is easily absorbed by the tongue or oral mucosa, and accumulates in the human body to cause cancer risk.
本發明之主要目的，在於解決習知添加抗菌劑的牙膏對人體產生健康危害，據此本發明提供一種口腔用組合物，其主要係為天然成分組成，亦可達到修復口腔的功能。 The main purpose of the present invention is to solve the health hazards of conventional toothpaste added with antibacterial agents to the human body. According to this, the present invention provides a composition for oral cavity, which is mainly composed of natural ingredients and can also achieve the function of restoring the oral cavity.
為達到上述目的，本發明提供一種口腔用組合物，其包含游離形式之鈣離子、蜂膠、桂皮萃取物、丁香萃取物及碳酸鈣，其中，鈣離子的含量為佔組合物總重量之2wt%至5wt%，鈣離子與碳酸鈣以1：8至1：20的重量比混合，而桂皮萃取物與丁香萃取物以1：1的重量比混合，蜂膠與桂皮萃取物以1：4的重量比混合。 To achieve the above object, the present invention provides an oral composition comprising free form of calcium ions, propolis, cinnamon extract, clove extract and calcium carbonate, wherein the content of calcium ions is 2wt% of the total weight of the composition To 5wt%, calcium ions and calcium carbonate are mixed in a weight ratio of 1:8 to 1:20, and cinnamon extract and clove extract are mixed in a weight ratio of 1:1, and propolis and cinnamon extract are mixed in a weight ratio of 1:4. Than mixed.
於其中一項實施例中，碳酸鈣的含量為佔組合物總重量之40wt%。 In one of the embodiments, the content of calcium carbonate is 40 wt% of the total weight of the composition.
於其中一項實施例中，鈣離子的來源係為氯化鈣、硫酸鈣、鋁矽酸鈣、碳酸鈣、氯化鈣、抗壞血酸鈣、氧化鈣、氫氧化鈣、乳酸鈣、檸檬酸鈣、葡糖酸鈣之其中一種或及其組成之群組，經3000℃以上高溫解離及螯合而成。 In one of the embodiments, the source of calcium ions is calcium chloride, calcium sulfate, calcium aluminosilicate, calcium carbonate, calcium chloride, calcium ascorbate, calcium oxide, calcium hydroxide, calcium lactate, calcium citrate, One of calcium gluconate or its group is formed by dissociating and chelating at high temperature above 3000℃.
於其中一項實施例中，更包含有甘油、起泡劑、天然膠、香料、糖蜜素、薄荷腦及水。 In one of the embodiments, it further contains glycerin, foaming agent, natural gum, flavor, molasses, menthol and water.
本發明另一實施例提供一種口腔用組合物之製備方法，其包含以下步驟：高溫解離：將含鈣礦物進行研磨混合，形成一含有鈣鹽的粉狀混合物，粉狀混合物在真空環境中加熱至3000℃以上，以解離粉狀混合物中鈣鹽之鈣離 子鍵結，並將具活性的鈣離子螯合形成游離形式之鈣離子；初次攪拌：游離形式之鈣離子與水配製成一鈣離子水溶液，並將桂皮萃取物及丁香萃取物以1：1的重量比加入於該鈣離子水溶液，於一介於75℃至85℃之攪拌溫度進行初步攪拌；以及二次攪拌：將含有桂皮萃取物與丁香萃取物之鈣離子水溶液，加入蜂膠、碳酸鈣、甘油、起泡劑及天然膠進行二次攪拌，其中，鈣離子與碳酸鈣以1：8至1：20的重量比混合，蜂膠與桂皮萃取物以1：4的重量比混合，而蜂膠、甘油、起泡劑及天然膠加入於該鈣離子水溶液係先經混合靜置，使甘油、起泡劑、天然膠與該鈣離子水溶液產生觸變，進而提升鈣離子水溶液的結構黏度，後續再進行二次攪拌成型。 Another embodiment of the present invention provides a method for preparing an oral composition, which includes the following steps: high temperature dissociation: grinding and mixing calcium-containing minerals to form a powdery mixture containing calcium salt, and the powdery mixture is heated in a vacuum environment To above 3000℃, to dissociate the calcium salt in the powder mixture The sub-bonding and chelating the active calcium ions to form calcium ions in free form; initial stirring: the free form of calcium ions are mixed with water to form a calcium ion aqueous solution, and the cinnamon extract and clove extract are divided into 1: The weight ratio of 1 is added to the calcium ion aqueous solution, and the initial stirring is carried out at a stirring temperature between 75°C and 85°C; and the second stirring: the calcium ion aqueous solution containing the cinnamon extract and the clove extract is added to the calcium ion aqueous solution, and propolis and calcium carbonate are added. , Glycerin, foaming agent and natural gum are mixed for the second time. Among them, calcium ions and calcium carbonate are mixed in a weight ratio of 1:8 to 1:20, and propolis and cassia bark extract are mixed in a weight ratio of 1:4, and propolis is mixed in a weight ratio of 1:8 to 1:20. , Glycerin, foaming agent and natural gum are added to the calcium ion aqueous solution to be mixed and allowed to stand to make the glycerin, foaming agent, natural gum and the calcium ion aqueous solution thixotropic, thereby increasing the structural viscosity of the calcium ion aqueous solution. Then carry out secondary stirring and molding.
於其中一項實施例中，於高溫解離步驟中，含鈣礦物之來源係為含有碳酸鈣之貝殼及珊瑚，貝殼與珊瑚的重量比例介於10wt%至90wt%：90wt%至10wt%進行研磨混合。 In one of the embodiments, in the high-temperature dissociation step, the sources of calcium-containing minerals are shells and corals containing calcium carbonate, and the weight ratio of shells to corals is between 10wt% to 90wt%: 90wt% to 10wt% for grinding mixing.
本發明另一實施例提供一種包括上述口腔用組合物的製品，其包含牙粉、牙膏、牙周凝膠、增白劑、漱口劑、咀嚼膠、牙本質小管封填劑、牙乳膏、牙齒填補物或***錠之形式。 Another embodiment of the present invention provides a product comprising the above oral composition, which comprises dentifrice, toothpaste, periodontal gel, whitening agent, mouthwash, chewing gum, dentin tubule sealing agent, tooth cream, In the form of dental fillings or lozenges.
本發明另一實施例提供一種以上述口腔用組合物製備用於預防或治療牙本質相關症狀或疾病之藥劑之用途。 Another embodiment of the present invention provides a use of the aforementioned oral composition to prepare a medicament for preventing or treating dentin-related symptoms or diseases.
藉此，本發明口腔用組合物主要係為天然成分組成，不添加化學抗菌劑，其中，鈣離子能夠有效地被人體吸收，能夠覆蓋在牙表面上，提供人體牙骨所需，以提高骨骼密度的效果，達到修復及保護牙齒之目的；而且，鈣離子的奈米結構還能用來封填牙本質小管之孔洞，進而阻斷冷熱酸痛的刺激，以達到改善牙本質的敏感性症狀。 As a result, the oral composition of the present invention is mainly composed of natural ingredients without adding chemical antibacterial agents. Among them, calcium ions can be effectively absorbed by the human body and can cover the surface of the teeth to provide human teeth and bones to improve bones. The effect of density can achieve the purpose of repairing and protecting teeth. Moreover, the nanostructure of calcium ions can also be used to seal the holes of the dentin tubules, thereby blocking the stimulation of cold and heat and soreness, so as to improve the symptoms of dentin sensitivity.
此外，口腔用組合物中的蜂膠、桂皮萃取物及丁香萃取物分別具有抗過敏、抗菌、清潔牙垢以及防止牙周病等功效；長期使用可以維持或改善牙齒健康，還具有消腫、預防口腔潰瘍、清潔及除菌之效果，甚至還能有效降低牙齦及口腔表面的止痛功效。 In addition, the propolis, cinnamon extract and clove extract in the oral composition have anti-allergic, antibacterial, tartar cleaning and prevention of periodontal diseases, respectively; long-term use can maintain or improve dental health, and it can also reduce swelling and prevent oral cavity. The effect of ulcers, cleaning and sterilization can even effectively reduce the analgesic effect of the gums and oral cavity surface.
S1:高溫解離 S1: High temperature dissociation
S2:初次攪拌 S2: initial mixing
S3:二次攪拌 S3: Secondary mixing
圖1係為本發明之製備流程圖。 Figure 1 is the preparation flow chart of the present invention.
為便於說明本發明於上述發明內容一欄中所表示的中心思想，茲以具體實施例表達。 In order to facilitate the description of the central idea of the present invention expressed in the column of the above-mentioned summary of the invention, specific embodiments are used to express it.
本發明所提及之「口腔表面」包含口內之任何軟或硬表面，包括舌之表面、硬及軟腭、頰黏膜、牙周、牙齦及牙表面。本文之「牙表面」為一種天然牙或人工齒列，包括牙冠、牙蓋、填充物、牙橋、假牙、牙移植物等硬質表面。 The "oral surface" mentioned in the present invention includes any soft or hard surface in the mouth, including the surface of the tongue, hard and soft palate, buccal mucosa, periodontal, gum and dental surfaces. "Tooth surface" in this article refers to a natural tooth or artificial dentition, including hard surfaces such as crowns, caps, fillings, bridges, dentures, and dental implants.
本發明提供一種口腔用組合物及其製備方法，其中，口腔用組合物主要包含游離形式之鈣離子、蜂膠、桂皮萃取物、丁香萃取物及碳酸鈣，除了上述外，口腔用組合物更可包含活性及/或載體成份。 The present invention provides an oral composition and a preparation method thereof. The oral composition mainly comprises free form of calcium ions, propolis, cinnamon extract, clove extract and calcium carbonate. In addition to the above, the oral composition is more suitable Contains active and/or carrier ingredients.
鈣離子，係由含鈣礦物在真空環境中經高溫及螯合而得，進一步來說，鈣離子的來源係為氯化鈣、硫酸鈣、鋁矽酸鈣、碳酸鈣、氯化鈣、抗壞血酸鈣、氧化鈣、氫氧化鈣、乳酸鈣、檸檬酸鈣、葡糖酸鈣之其中一種或及其 組成之群組，於一較佳實施例中，鈣離子的含量為佔組合物總重量之2wt%至5wt%，且鈣離子與碳酸鈣以1：8至1：20的重量比混合。 Calcium ions are obtained by high temperature and chelation of calcium-containing minerals in a vacuum environment. Further, the sources of calcium ions are calcium chloride, calcium sulfate, calcium aluminosilicate, calcium carbonate, calcium chloride, and ascorbic acid Calcium, calcium oxide, calcium hydroxide, calcium lactate, calcium citrate, calcium gluconate or one of them In a preferred embodiment, the content of calcium ions is 2wt% to 5wt% of the total weight of the composition, and the calcium ions and calcium carbonate are mixed in a weight ratio of 1:8 to 1:20.
值得說明的是，鈣離子係一種水溶性的活性鈣離子劑，其pH值位於8.5以上，屬於強鹼性，能夠中和口腔酸性；經臨床研究證實，鈣離子結構類似於琺瑯質且容易被人體高度吸收，因此本發明鈣離子能夠有效地覆蓋在牙表面，提供人體牙骨所需以提高骨骼密度，達到修復及保護牙齒之目的。 It is worth noting that calcium ion is a water-soluble active calcium ion agent with a pH value above 8.5, which is strongly alkaline and can neutralize oral acidity; clinical studies have confirmed that the structure of calcium ion is similar to enamel and is easily affected by the human body. It is highly absorbed, so the calcium ions of the present invention can effectively cover the surface of the teeth, provide the human bones needed to increase the bone density, and achieve the purpose of repairing and protecting teeth.
此外，鈣離子還能用來封填牙本質小管之孔洞，進而阻斷冷熱酸痛的刺激，以達到改善牙本質的敏感性症狀；除此之外，鈣離子具有凝血功能及減少牙齦流血的功效，可用來降低牙周病的發生率。 In addition, calcium ions can also be used to seal the cavities of the dentin tubules, thereby blocking the stimulation of hot and cold soreness, so as to improve the symptoms of dentin sensitivity; in addition, calcium ions have the effect of clotting and reducing gum bleeding. , Can be used to reduce the incidence of periodontal disease.
蜂膠，是蜜蜂用從植物幼芽與樹幹上採集來的樹脂，混入它的上顎腺分泌物和蜂蠟等加工而成的一種具有芳香氣味的膠狀固體物質。經藥理研究證實，蜂膠配製成蜂膠酊具有抗過敏、抗菌、清潔牙垢以及防止牙周病等功效；長期使用可以維持或改善牙齒健康，還具有消腫、預防口腔潰瘍、清潔及除菌之目的。 Propolis is a kind of fragrant gelatinous solid material processed by bees using resin collected from plant buds and tree trunks, mixed with its mandibular gland secretions and beeswax. Pharmacological studies have confirmed that propolis tincture formulated with propolis has anti-allergic, anti-bacterial, cleansing tartar and prevention of periodontal diseases; long-term use can maintain or improve dental health, and it can also reduce swelling, prevent oral ulcers, clean and sterilize purpose.
桂皮，為樟科植物，現代藥理研究發現，桂皮萃取物含兒茶素、花青素、香葉草醇和丁香酚等成分，肉桂是藥食兩用的中藥，有散寒止痛、活血、健胃等功效。發明人以實驗證實，添加桂皮萃取物在本發明的口腔用組合物中，可有效降低牙齦及口腔表面的止痛效果。 Cinnamon is a plant of the Lauraceae family. Modern pharmacological studies have found that the extract of cinnamon contains catechins, anthocyanins, geraniol and eugenol. Stomach and other functions. The inventors have confirmed through experiments that the addition of cinnamon extract in the oral composition of the present invention can effectively reduce the analgesic effect of the gums and oral cavity surface.
丁香，為桃金娘科植物(一般的觀賞花木丁香為木犀科植物，要予以區別)，以花蕾和果實入藥；丁香萃取物含丁香油及丁香酚，本發明利用丁香萃取物中的成分，以作為局部性麻醉、止痛、解熱及抗炎的藥理作用。發明人以實驗證實在本發明的口腔用組合物中添加丁香萃取物，可改善口腔表面 發炎症狀，而且丁香油及丁香酚還可進一步達到局部止痛及麻醉的效果，可用來降低牙周病的發生率，有效降低牙齦及口腔表面的止痛效果。 Clove is a plant of the Myrtaceae family (general ornamental flower and tree Clove is a plant of the Oleaceae family, to be distinguished), which is used as a medicine with flower buds and fruits; the clove extract contains clove oil and eugenol, and the present invention uses the ingredients in the clove extract to It is used as a local anesthetic, analgesic, antipyretic and anti-inflammatory pharmacological effect. The inventors have confirmed through experiments that adding clove extract to the oral composition of the present invention can improve the oral cavity surface Inflammation symptoms, and clove oil and eugenol can further achieve the effect of local pain relief and anesthesia, which can be used to reduce the incidence of periodontal disease and effectively reduce the analgesic effect on the gums and oral surface.
於本實施例中，蜂膠與桂皮萃取物以1：4的重量比混合，桂皮萃取物與丁香萃取物以1：1的重量比混合；而且，本發明口腔用組合物更包含甘油、起泡劑、天然膠、香料、糖蜜素、薄荷腦及水；具體來說，本發明口腔用組合物係用來製成牙膏形式，因此甘油、起泡劑及天然膠在牙膏製程中，係作為產生觸變現象，進而提升結構的黏度，以使口腔用組合物形成半固體的載體。 In this embodiment, propolis and cinnamon extract are mixed in a weight ratio of 1:4, and cinnamon extract and clove extract are mixed in a weight ratio of 1:1; and the oral composition of the present invention further contains glycerin and foaming Toothpaste, natural gums, flavors, molasses, menthol, and water; specifically, the oral composition of the present invention is used to form a toothpaste form, so glycerin, foaming agent and natural gums are used as a product in the toothpaste manufacturing process. The thixotropic phenomenon further increases the viscosity of the structure, so that the oral composition forms a semi-solid carrier.
於本文時，「半固體」可為一種凝膠、膠體或膠質。當用於本文時，半固體及液體為在黏度之基礎上有所區分之流體：半固體為高黏度流體，而液體具有低黏度。在兩種流體之間沒有明確的區分線。 As used herein, "semi-solid" can be a gel, colloid or colloid. As used herein, semi-solid and liquid are fluids that are distinguished on the basis of viscosity: semi-solid is a high-viscosity fluid, and liquid has a low viscosity. There is no clear line of distinction between the two fluids.
就以本發明實施例來說，以重量來計，鈣離子的含量為佔組合物總重量之2wt%至5wt%，蜂膠為佔組合物總重量之0.5wt%、桂皮萃取物為佔組合物總重量之2wt%、丁香萃取物為佔組合物總重量之2wt%、碳酸鈣的含量為佔組合物總重量之40wt%、天然成分萃取物為佔組合物總重量之3wt%、甘油為佔組合物總重量之15wt%、起泡劑為佔組合物總重量之3wt%、天然膠為佔組合物總重量之0.8wt%、香料為佔組合物總重量之2wt%、糖蜜素為佔組合物總重量之1wt%、薄荷腦為佔組合物總重量之1wt%以及餘量的水，但不限於此。 For the example of the present invention, the content of calcium ions is 2wt% to 5wt% of the total weight of the composition by weight, the propolis is 0.5wt% of the total weight of the composition, and the cinnamon extract is the composition. 2wt% of the total weight, clove extract is 2wt% of the total weight of the composition, the content of calcium carbonate is 40wt% of the total weight of the composition, the natural ingredient extract is 3wt% of the total weight of the composition, and glycerin is The total weight of the composition is 15wt%, the foaming agent is 3wt% of the total weight of the composition, the natural gum is 0.8wt% of the total weight of the composition, the fragrance is 2wt% of the total weight of the composition, and the molasses is the composition 1wt% of the total weight of the composition, menthol is 1wt% of the total weight of the composition and the balance of water, but not limited thereto.
請配合參閱圖1所示，係為本發明口腔用組合物之製備方法，其包含下列步驟：高溫解離S1：首先，將含鈣礦物進行研磨混合，形成一含有鈣鹽的粉狀混合物，於本實施例中，含鈣礦物之來源係為含有碳酸鈣之貝殼及珊瑚，貝殼與珊瑚的重量比例介於10wt%至90wt%：90wt%至10wt%進行研磨及混合成 粉狀混合物，後續將混合物置放在真空環境中加熱鍵解。 Please refer to Fig. 1, which is the preparation method of the oral composition of the present invention, which includes the following steps: high temperature dissociation S1: firstly, the calcium-containing minerals are ground and mixed to form a powdery mixture containing calcium salts. In this embodiment, the sources of calcium-containing minerals are shells and corals containing calcium carbonate, and the weight ratio of shells to corals is between 10wt% to 90wt%: 90wt% to 10wt% are ground and mixed into The powdery mixture is then placed in a vacuum environment to heat the bond to dissolve.
一般來說，在一大氣壓下將鈣鹽(碳酸鈣)加熱到900℃會分解成氧化鈣和二氧化碳；於本發明於實際操作時，係將混合物中的鈣鹽加熱至3000℃以上，進而破壞鈣離子的鍵結，變成活性鈣離子之後，再將具活性的鈣離子以螯合技術回收形成游離形式之鈣離子，且鈣離子經螯合技術後，能夠提高人體組織細胞對鈣離子的吸收之目的。 Generally speaking, heating calcium salt (calcium carbonate) to 900°C under atmospheric pressure will decompose into calcium oxide and carbon dioxide; in the actual operation of the present invention, the calcium salt in the mixture is heated to above 3000°C to destroy After the binding of calcium ions becomes active calcium ions, the active calcium ions are recovered by chelating technology to form calcium ions in free form. After the calcium ions are chelated, the absorption of calcium ions by human tissue cells can be improved. The purpose.
初次攪拌S2：接著，游離形式之鈣離子與水配製成一鈣離子水溶液，再將桂皮萃取物及丁香萃取物以1：1的重量比混合，加入於鈣離子水溶液中，後續含有桂皮萃取物與丁香萃取物的鈣離子水溶液加熱至一攪拌溫度進行初步攪拌，其中，攪拌溫度介於75℃至85℃，能夠有效釋放且不破壞桂皮萃取物與丁香萃取物的成分結構。 Initial stirring S2: Then, the free form of calcium ions and water are prepared into a calcium ion aqueous solution, then the cinnamon extract and clove extract are mixed in a weight ratio of 1:1, and added to the calcium ion aqueous solution, followed by cinnamon extract The calcium ion aqueous solution of the cinnamon extract and the clove extract is heated to a stirring temperature for preliminary stirring, wherein the stirring temperature is between 75°C and 85°C, which can effectively release without destroying the composition structure of the cinnamon extract and the clove extract.
二次攪拌S3：在初次攪拌S2後，將含有桂皮萃取物與丁香萃取物的鈣離子水溶液加入蜂膠、碳酸鈣、甘油、起泡劑及天然膠進行二次攪拌，其中，蜂膠與桂皮萃取物以1：4的重量比混合，鈣離子與碳酸鈣以1：8至1：20的重量比混合；進一步來說，本實施例口腔用組合物係用於製成牙膏，因此需先經混合靜置6小時，使甘油、起泡劑及天然膠與鈣離子水溶液產生觸變現象，進而提升鈣離子水溶液的結構黏度，以使口腔用組合物形成半固體的載體後，再繼續進行二次攪拌1至2天，使得口腔用組合物形成牙膏製品進行填充作業。 Secondary stirring S3: After the initial stirring of S2, the calcium ion aqueous solution containing cinnamon extract and clove extract is added to propolis, calcium carbonate, glycerin, foaming agent and natural gum for secondary stirring. Among them, propolis and cinnamon extract Mix in a weight ratio of 1:4, and mix calcium ions and calcium carbonate in a weight ratio of 1:8 to 1:20; further, the oral composition of this example is used to make toothpaste, so it needs to be mixed first Let stand for 6 hours to cause thixotropy of glycerin, foaming agent, natural rubber and calcium ion aqueous solution, thereby increasing the structural viscosity of the calcium ion aqueous solution, so that the oral composition becomes a semi-solid carrier, and then proceed to the second step. Stir for 1 to 2 days to make the oral composition form a toothpaste product for filling operation.
另外，本發明之口腔用組合物可採適用於口腔表面之任何形式。於不同例示實施例中，口腔用組合物可為製備成提供刷洗、漱口或噴霧之製品；比如牙粉、牙周凝膠、適合供塗刷牙表面(例如增白劑)之液體、漱口劑、咀嚼膠(例如口香糖)、牙本質小管封填劑、牙乳膏(如潔牙幕斯)、牙齒填補物、***錠 等；但不限於此，本發明口腔用組合物更可經由導入口中與口腔組織接觸的劑型即可無限制地使用，並且所述口腔用組合物可藉由本領域之技術人員所知之一般方法成型。 In addition, the oral composition of the present invention can take any form suitable for the surface of the oral cavity. In different exemplary embodiments, the oral composition may be a product prepared to provide brushing, mouthwash or spray; such as tooth powder, periodontal gel, liquid suitable for brushing the surface (such as whitening agent), mouthwash , Chewing gums (e.g. chewing gum), dentin tubule sealants, tooth creams (e.g. dentifrices), dental fillings, lozenges Etc.; but not limited to this, the oral composition of the present invention can be introduced into the mouth to contact the oral tissue in a dosage form that can be used without limitation, and the oral composition can be used by general methods known to those skilled in the art forming.
藉此，本發明口腔用組合物主要係為天然成分組成，不添加化學抗菌劑，且鈣離子能夠有效地被人體吸收，進而能覆蓋在牙表面上，提供人體牙骨所需，以提高骨骼密度的效果；而且，鈣離子的奈米結構還能用來封填牙本質小管孔洞，進而阻斷冷熱酸痛的刺激，以達到改善牙本質的敏感性症狀。 Thereby, the oral composition of the present invention is mainly composed of natural ingredients, no chemical antibacterial agent is added, and calcium ions can be effectively absorbed by the human body, and then can be covered on the tooth surface to provide human teeth and bones to improve bones. The effect of density; moreover, the nanostructure of calcium ions can also be used to seal dentin tubules, thereby blocking the stimulation of hot and cold soreness, so as to improve the symptoms of dentin sensitivity.
再者，口腔用組合物中的蜂膠、桂皮萃取物及丁香萃取物分別具有抗過敏、抗菌、清潔牙垢以及防止牙周病等功效；長期使用可以維持或改善牙齒健康，還具有消腫、預防口腔潰瘍、清潔及除菌之效果，甚至還能有效降低牙齦及口腔表面的止痛功效。 Furthermore, the propolis, cinnamon extract and clove extract in the oral composition have anti-allergic, antibacterial, cleansing tartar and prevention of periodontal disease, respectively; long-term use can maintain or improve dental health, and it can also reduce swelling and prevent The effect of oral ulcers, cleaning and sterilization can even effectively reduce the analgesic effect of the gums and oral surface.
另外，本發明口腔用組合物還能製備用於預防或治療牙本質相關症狀或疾病之藥劑之用途，也就是說，口腔用組合物之鈣離子能夠封填牙本質小管，進而阻斷冷熱酸痛的刺激，以達到預防或治療牙本質的敏感性症狀。 In addition, the oral composition of the present invention can also be used as a medicament for preventing or treating dentin-related symptoms or diseases, that is to say, the calcium ions of the oral composition can seal the dentin tubules, thereby blocking hot and cold soreness To prevent or treat the symptoms of dentin sensitivity.
藉此以上所舉實施例僅用以說明本發明而已，非用以限制本發明之範圍。舉凡不違本發明精神所從事的種種修改或變化，俱屬本發明意欲保護之範疇。 Therefore, the above-mentioned embodiments are only used to illustrate the present invention, and are not used to limit the scope of the present invention. All modifications or changes made without violating the spirit of the present invention fall within the scope of the present invention's intended protection.
S1:高溫解離 S1: High temperature dissociation
S2:初次攪拌 S2: initial mixing
S3:二次攪拌 S3: Secondary mixing
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW200902080A (en) * | 2007-01-10 | 2009-01-16 | Colgate Palmolive Co | Oral care compositions comprising a hippophae extract |
| CN104873446A (en) * | 2015-05-27 | 2015-09-02 | 闭炳春 | Cinnamon oil containing toothpaste |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200902080A (en) * | 2007-01-10 | 2009-01-16 | Colgate Palmolive Co | Oral care compositions comprising a hippophae extract |
| CN104873446A (en) * | 2015-05-27 | 2015-09-02 | 闭炳春 | Cinnamon oil containing toothpaste |
Non-Patent Citations (1)
| Title |
|---|
| "泛美頂級活性鈣離子(離子鈣)", 網址：https://www.yes2100.com/information.asp?id=304, 上網日期：2018年10月25日. * |
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