CN108743442A - Sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash and preparation method - Google Patents
Sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash and preparation method Download PDFInfo
- Publication number
- CN108743442A CN108743442A CN201810786909.2A CN201810786909A CN108743442A CN 108743442 A CN108743442 A CN 108743442A CN 201810786909 A CN201810786909 A CN 201810786909A CN 108743442 A CN108743442 A CN 108743442A
- Authority
- CN
- China
- Prior art keywords
- mouth wash
- compound formula
- formula mouth
- zinc ion
- cetylpyridinium chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash, raw material main ingredient is sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion, and auxiliary material is menthol, saccharin sodium, 95% ethyl alcohol, glycerine；The mass fraction that the Cetylpyridinium Chloride accounts for compound formula mouth wash is 0.05~0.2%, the mass fraction that the zinc ion accounts for compound formula mouth wash is 0.5~1%, the mass fraction that the menthol accounts for compound formula mouth wash is 0.3g/L, the mass fraction that the saccharin sodium accounts for compound formula mouth wash is 0.3g/L, the volume fraction that the ethyl alcohol accounts for compound formula mouth wash is 65ml/L, the volume fraction that the glycerine accounts for compound formula mouth wash is 75ml/L, and surplus is distilled water.Sodium azulenesulfonate category non-steroidal anti-inflammatory agent of the present invention, no bactericidal effect can be used for a long time so normal oral cavity flora balance will not be destroyed.
Description
Technical field
The present invention relates to mouthwash technical field, especially sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound prescriptions to gargle
Water and preparation method.
Background technology
Oral cavity common disease mainly has：Gingivitis, periodontitis, alveolar abscess, canker sore etc..Intraoral periodontal support group
It knits by local stimulation, such as dental calculus, food impaction, ill fitting prosthesis, long-term mechanical stimulus, denture are uneven, part tooth is stung
Solidum is excessive and incorrect method for brushing teeth, chemicals, burn, hypovitaminosis C, oral cavity bacterium growth etc.
It is the main reason for causing oral cavity common disease.
Now occur in the domestic market it is many treatment oral cavity common diseases medicated toothpaste, mainly have Chinese medicinal toothpaste and added with
The toothpaste of antimicrobial.Chinese medicinal toothpaste is that the Chinese medicine with heat-clearing, detoxication is added on the basis of ordinary toothpaste, to gum
Inflammation, periodontitis, halitosis have exact therapeutic effect, and the inflammation to alleviating gum has certain booster action.And added with anti-
The toothpaste of bacterium medicine is that some antimicrobial components are added on the basis of ordinary toothpaste, the formation for inhibiting plaque.
Sodium azulenesulfonate is the water-soluble substances of yellow chamomile effective ingredients in plant, has anti-inflammatory antiulcer effect, especially matches
There is good therapeutic effect to common mouth disease with Chinese herbal medicine, the oedema caused by above-mentioned disease can be effectively eliminated, filled
The symptoms such as blood, abscess, bleeding gums, halitosis, odontoseisis.Canker sore is a kind of diseases of oral mucosa of recurrent exerbation, Azulene sulfonic acid
Sodium is equipped with Chinese herbal medicine also has good curative effect to canker sore.
Invention content
In view of the above problems, it is multiple that the object of the present invention is to provide a kind of sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ions
Close formula mouth wash and preparation method.
The technical scheme is that：Sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash, raw material are main
Composition is sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion, and auxiliary material is menthol, saccharin sodium, 95% ethyl alcohol, glycerine；The western pyrrole
The mass fraction that oronain accounts for compound formula mouth wash is 0.05~0.2%, and the zinc ion accounts for the quality of compound formula mouth wash
Score is 0.5~1%, and the mass fraction that the menthol accounts for compound formula mouth wash is 0.3g/L, and the saccharin sodium accounts for compound
The mass fraction of formula mouth wash is 0.3g/L, and the volume fraction that the ethyl alcohol accounts for compound formula mouth wash is 65ml/L, described
The volume fraction that glycerine accounts for compound formula mouth wash is 75ml/L, and surplus is distilled water.
Further, the one kind of the zinc ion in zinc acetate or zinc citrate.
The preparation method of sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash is specially：By Cetylpyridinium Chloride and
Zinc ion is dissolved in distilled water, and menthol is dissolved in 95% ethyl alcohol, and menthol ethanol is added in aqueous solution and is stirred, and is added simultaneously
Enter glycerine；Simultaneously distilled water is added in mixing, obtains sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) the Cetylpyridinium Chloride category cationic surfactant that the present invention uses can cause cell membrane disorderly, reach antibacterial
Effect mitigates implication in turn, is gargled for daily 3~4 times with the gargle containing Cetylpyridinium Chloride, and the formation of plaque can be made to reduce by 30%；
Zinc ion can reduce the metabolic activity of bacterium in plaque, achieve the effect that inhibit bacterial plaque, and can by with the calcium in saliva
Ion is combined into line replacement with substances such as carboxyl, phosphate, is able to for a long time be detained in oral cavity, obtains slowly lasting release.
(2) sodium azulenesulfonate category non-steroidal anti-inflammatory agent of the present invention, no bactericidal effect, so normal oral cavity flora will not be destroyed
Balance, can be used for a long time.
Specific implementation mode
With reference to embodiment, the present invention is further illustrated.
Embodiment 1
Raw material is that Cetylpyridinium Chloride, zinc acetate, sodium azulenesulfonate are as the main component, auxiliary material be menthol, 95% ethyl alcohol, glycerine,
Distilled water, saccharin sodium.
Precision weighs 0.5g Cetylpyridinium Chlorides, 2.5g zinc acetates, 2.86g sodium azulenesulfonates and 0.15g saccharin sodiums, is dissolved in 300ml
It in distilled water, separately weighs 0.2g menthols and is dissolved in 95% ethyl alcohol of 30ml, menthol ethanol is added in aqueous solution and is stirred,
40ml glycerine is added with method, distilled water is added to 500ml in mixing, and mixing obtains compound formula mouth wash.
Embodiment 2
Raw material is that Cetylpyridinium Chloride, zinc acetate, sodium azulenesulfonate are as the main component, auxiliary material be menthol, 95% ethyl alcohol, glycerine,
Distilled water.
Precision weighs 0.5g Cetylpyridinium Chlorides, 2.1g sodium azulenesulfonates and 2.5g zinc acetates, is dissolved in about 300ml distilled water, separately
It weighs 0.2g menthols to be dissolved in 95% ethyl alcohol of 30ml, menthol ethanol is added in aqueous solution and is stirred, 40ml is added with method
Distilled water is added to 500ml in glycerine, mixing, and mixing obtains compound formula mouth wash.
It is enlightenment with above-mentioned desirable embodiment according to the present invention, through the above description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property range is not limited to the contents of the specification, it is necessary to determine its technical scope according to right.
Claims (3)
1. sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash, which is characterized in that its raw material main ingredient is Azulene sulphur
Sour sodium, Cetylpyridinium Chloride and zinc ion, auxiliary material are menthol, saccharin sodium, 95% ethyl alcohol, glycerine；The Cetylpyridinium Chloride accounts for compound
The mass fraction of formula mouth wash be 0.05~0.2%, the zinc ion account for compound formula mouth wash mass fraction be 0.5~
1%, the mass fraction that the menthol accounts for compound formula mouth wash is 0.3g/L, and the saccharin sodium accounts for compound formula mouth wash
Mass fraction is 0.3g/L, and the volume fraction that the ethyl alcohol accounts for compound formula mouth wash is 65ml/L, and the glycerine accounts for compound match
The volume fraction of square mouthwash is 75ml/L, and surplus is distilled water.
2. sodium azulenesulfonate according to claim 1, Cetylpyridinium Chloride and zinc ion compound formula mouth wash, which is characterized in that
The one kind of the zinc ion in zinc acetate or zinc citrate.
3. the method for preparing sodium azulenesulfonate as claimed in claim 1 or 2, Cetylpyridinium Chloride and zinc ion compound formula mouth wash,
It is characterised in that it includes following steps：The Cetylpyridinium Chloride and zinc ion are dissolved in distilled water, the menthol is dissolved in 95%
In ethyl alcohol, the menthol ethanol is added in aqueous solution and is stirred, while glycerine is added；Simultaneously distilled water is added in mixing, obtains
Sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810786909.2A CN108743442A (en) | 2018-07-17 | 2018-07-17 | Sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810786909.2A CN108743442A (en) | 2018-07-17 | 2018-07-17 | Sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash and preparation method |
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| Publication Number | Publication Date |
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| CN108743442A true CN108743442A (en) | 2018-11-06 |
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| CN201810786909.2A Pending CN108743442A (en) | 2018-07-17 | 2018-07-17 | Sodium azulenesulfonate, Cetylpyridinium Chloride and zinc ion compound formula mouth wash and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089680A (en) * | 2019-05-31 | 2020-12-18 | 王飞 | Effervescent tablet for self-made mouthwash |
| CN112402278A (en) * | 2020-11-16 | 2021-02-26 | 北京华素制药股份有限公司 | Sodium azulene sulfonate compound gargle and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780016A (en) * | 2009-01-16 | 2010-07-21 | 上海交通大学医学院附属第九人民医院 | Compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and preparation method thereof |
| CN106265423A (en) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | Having relieves inflammation or internal heat disappear pain effect oral care composition |
| CN107095795A (en) * | 2017-03-15 | 2017-08-29 | 重庆登康口腔护理用品股份有限公司 | A kind of sodium azulenesulfonate composition, oral-cavity article and preparation method thereof |
| CN107951733A (en) * | 2017-11-16 | 2018-04-24 | 江苏大学 | The preparation and its application of Azulene sodium sulfonate and Cetylpyridinium Chloride compound mouthwash |
-
2018
- 2018-07-17 CN CN201810786909.2A patent/CN108743442A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780016A (en) * | 2009-01-16 | 2010-07-21 | 上海交通大学医学院附属第九人民医院 | Compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and preparation method thereof |
| CN106265423A (en) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | Having relieves inflammation or internal heat disappear pain effect oral care composition |
| CN107095795A (en) * | 2017-03-15 | 2017-08-29 | 重庆登康口腔护理用品股份有限公司 | A kind of sodium azulenesulfonate composition, oral-cavity article and preparation method thereof |
| CN107951733A (en) * | 2017-11-16 | 2018-04-24 | 江苏大学 | The preparation and its application of Azulene sodium sulfonate and Cetylpyridinium Chloride compound mouthwash |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089680A (en) * | 2019-05-31 | 2020-12-18 | 王飞 | Effervescent tablet for self-made mouthwash |
| CN112402278A (en) * | 2020-11-16 | 2021-02-26 | 北京华素制药股份有限公司 | Sodium azulene sulfonate compound gargle and preparation method thereof |
| CN112402278B (en) * | 2020-11-16 | 2022-09-06 | 北京华素制药股份有限公司 | Sodium azulene sulfonate compound gargle and preparation method thereof |
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Application publication date: 20181106 |