TWI615131B - Image based oxygen saturation measuring device and method thereof - Google Patents

Image based oxygen saturation measuring device and method thereof Download PDF

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TWI615131B
TWI615131B TW102143542A TW102143542A TWI615131B TW I615131 B TWI615131 B TW I615131B TW 102143542 A TW102143542 A TW 102143542A TW 102143542 A TW102143542 A TW 102143542A TW I615131 B TWI615131 B TW I615131B
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light
red
infrared light
oxygen concentration
blood oxygen
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TW201519869A (en
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蔡心怡
黃國政
陳怡如
張漢釗
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財團法人國家實驗研究院
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Abstract

本發明為一種影像式血氧濃度的檢測裝置及方法,該方法包含下列步驟:提供發射複數道交替出現並均勻分佈的紅光與紅外光,其中該選定皮膚區域具有複數個座標點;控制該複數道紅光與紅外光輪流照射至該選定皮膚區域上,以具有一紅光期與一紅外光期;接收反射自該皮膚區域上之複數道紅光與複數道紅外光;及分析計算該複數道經反射之紅光與紅外光之光強度,以得到該選定皮膚區域上各座標點之一血氧濃度指數,並建立血氧濃度分佈。藉由本發明之裝置及方法,血氧濃度之測量較不受外界訊號強度與人體末稍循環不良之影響,且可單次完成皮膚表面大面積的測量。 The present invention is an apparatus and method for detecting image blood oxygen concentration, the method comprising the steps of: providing a plurality of red and infrared light that alternately appear and uniformly distributed, wherein the selected skin region has a plurality of coordinate points; a plurality of red and infrared light are alternately irradiated onto the selected skin region to have a red light period and an infrared light period; receiving a plurality of red light and a plurality of infrared light reflected from the skin region; and analyzing and calculating The intensity of the reflected light of the red and infrared light is obtained to obtain a blood oxygen concentration index of each of the coordinate points on the selected skin region, and a blood oxygen concentration distribution is established. With the device and method of the present invention, the measurement of blood oxygen concentration is less affected by the external signal intensity and the poor circulation of the human body, and the large-area measurement of the skin surface can be completed in a single time.

Description

影像式血氧濃度檢測裝置與方法 Imaging blood oxygen concentration detecting device and method

本發明係關於一種血氧濃度檢測的技術;更明確說來,本發明係關於一種影像式血氧濃度的檢測裝置及方法。 The present invention relates to a technique for detecting blood oxygen concentration; more specifically, the present invention relates to an apparatus and method for detecting image blood oxygen concentration.

人體的血氧濃度攸關身體健康,故有血氧濃度檢測技術的提出與相關裝置與方法的存在,藉此可達到對身體疾病的監控與預防之目的。 The blood oxygen concentration of the human body is related to the health of the body. Therefore, there are suggestions for the detection of blood oxygen concentration and the existence of related devices and methods, thereby achieving the purpose of monitoring and preventing the physical diseases.

血氧計即是用來量測人體血液中血紅素(Hemoglobin)帶氧量的一種醫療儀器。有別於抽血採樣分析的量測方式,血氧計係利用非侵入式的光調變技術做測量,藉由兩束能分別被人體血液中之帶氧血紅素及去氧血紅素吸收的特定波長光源,照射在人體血管密集的皮膚組織,即可依據輸出光與原入射光的強度變化得到人體血液中帶氧血紅素及去氧血紅素的個別濃度變化訊號,其中受測之皮膚區域可為手指、耳垂或大腿處者,且輸出光與入射光之強度變化之所以可作為判定血氧濃度之依據是因帶氧血紅素及去氧血紅素濃度之濃淡所調變的物理現象。接著,光電轉換技術被用以取得這該二血紅素的電氣型態訊號,再配合微處理機的程式運算,即可根據血氧濃度的定義公式計算出血氧濃度值(亦稱血氧飽和度)。 An oximeter is a medical device used to measure the amount of hemoglobin (Hemoglobin) in human blood. Different from the measurement method of blood sampling analysis, the oximeter is measured by non-invasive light modulation technology, and the two beams can be absorbed by the hemoglobin and deoxyhemoglobin in the human blood, respectively. The specific wavelength light source is irradiated on the skin tissue of the human blood vessel, and the individual concentration change signals of the oxygenated hemoglobin and the deoxyhemoglobin in the human blood can be obtained according to the intensity change of the output light and the original incident light, wherein the skin area to be tested is measured. It can be a finger, earlobe or thigh, and the change in intensity of output light and incident light can be used as a basis for determining the blood oxygen concentration as a physical phenomenon modulated by the concentration of oxygenated hemoglobin and deoxyhemoglobin. Then, the photoelectric conversion technology is used to obtain the electrical type signal of the hemoglobin, and in conjunction with the program calculation of the microprocessor, the hemorrhagic oxygen concentration value (also known as blood oxygen saturation) can be calculated according to the definition formula of blood oxygen concentration. degree).

一般係以紅光與紅外光當作該二測量用光源,且波長分別為660nm與940nm。此外,習用之此類裝置皆僅係以點光源針對單點皮膚做測量,但受測者可能末稍循環較不足,以致所得血氧濃度資訊未能真實反應受測者之一般血氧 濃度,且對於其它皮膚處之含氧量資訊無法一次掌握,故須分次進行多點測量方能掌握含氧量資訊。 Generally, red light and infrared light are used as the light sources for the two measurements, and the wavelengths are 660 nm and 940 nm, respectively. In addition, the conventional devices of this type are only measured by a point light source for a single point of skin, but the subject may have insufficient circulation at the end, so that the obtained blood oxygen concentration information does not truly reflect the general blood oxygen of the subject. The concentration, and the information on the oxygen content of other skins can not be mastered at a time, so it is necessary to conduct multi-point measurement in multiple steps to master the oxygen content information.

一般習用此類裝置皆係以穿透皮膚之透射光作為上述之輸出光,並以該透射光作為判斷紅光與紅外光之光強度的依據。另亦有一種以經反射之紅光與紅外光作相對於入射之紅光與紅外光作為測量血氧濃度的技術,但其所一次測量之皮膚區域仍為單點。 Generally, such devices are used to transmit light transmitted through the skin as the above-mentioned output light, and the transmitted light is used as a basis for judging the light intensity of red light and infrared light. There is also a technique for measuring the blood oxygen concentration by reflecting red light and infrared light with respect to incident red light and infrared light, but the skin area measured at one time is still a single point.

此外,以穿透式光作為測量基礎的資料容易受到血流不足、使用之光強度、膚色不同及不規律的脈搏等的影響,故其準確性仍有提升的空間。 In addition, the data based on penetrating light is easily affected by insufficient blood flow, light intensity, skin color, and irregular pulse, so there is still room for improvement in accuracy.

鑑於上述,習用血氧計仍有其待克服之處,故本發明提出一種既能避開穿透式機制與超越單點測量面積的影像式血氧濃度檢測裝置及方法,藉以提升其使用之便利性與準確性。 In view of the above, the conventional oximeter still has its problems to be overcome, so the present invention proposes an image blood oxygen concentration detecting device and method capable of avoiding the penetrating mechanism and exceeding the single-point measuring area, thereby improving the use thereof. Convenience and accuracy.

鑑於上述,本發明之一目的即在於提出一種影像式血氧濃度檢測裝置及方法,其係以反射式光為測量基礎,以得到較佳之準確性,並能針對人體大範圍皮膚做測量。 In view of the above, an object of the present invention is to provide an image blood oxygen concentration detecting device and method which are based on reflective light to obtain better accuracy and can measure a wide range of skin of the human body.

本發明之影像式血氧濃度檢測裝置包含一燈源單元、一運算處理單元、一影像接收單元、一影像分析/計算單元、及一血氧濃度分佈圖建立單元。該燈源單元包含一支架組件、一紅光燈組及一紅外光燈組,且該紅光燈組包含複數個紅光燈,該紅外光燈組包含複數個紅外光燈,皆設於該支架組件上,且該等紅光燈與紅外光燈分別交替出現並均勻排列於該燈源單元上,並在開啟時分別發出紅光與紅外光,以照射至一受測者身體之一選定皮膚區域上,其中該選定皮膚區域具有複數個座標點;該運算處理單元控制該紅光燈組之紅光燈與該紅外光燈組之紅外光燈輪流開啟,以具有一紅光期與一紅外光期;該影像接收單元,接收反射自該皮膚區 域上之複數道紅光與複數道紅外光;且該影像分析/計算單元,分析計算該複數道經反射之紅光與紅外光之光強度,以得到該選定皮膚區域上各座標點之一血氧濃度指數。 The image blood oxygen concentration detecting device of the present invention comprises a light source unit, an arithmetic processing unit, an image receiving unit, an image analyzing/calculating unit, and a blood oxygen concentration distribution map establishing unit. The light source unit includes a bracket assembly, a red light group and an infrared light group, and the red light group includes a plurality of red lights, and the infrared light group includes a plurality of infrared lights, all of which are disposed in the On the bracket assembly, the red light and the infrared light are alternately arranged and evenly arranged on the light source unit, and respectively emit red light and infrared light when being turned on to illuminate one of the subject's body to be selected. The skin area, wherein the selected skin area has a plurality of coordinate points; the operation processing unit controls the red light of the red light group and the infrared light of the infrared light group to turn on to have a red light period and a Infrared light period; the image receiving unit receives reflection from the skin area a plurality of red light and a plurality of infrared rays on the domain; and the image analysis/calculation unit analyzes and calculates the light intensity of the reflected red light and the infrared light to obtain one of the coordinate points on the selected skin region Blood oxygen concentration index.

本發明之影像式血氧濃度檢測方法包含下列步驟:提供發射複數道交替出現並均勻分佈的紅光與紅外光,以照射至一受測者身體之一選定皮膚區域上,其中該選定皮膚區域具有複數個座標點;控制該複數道紅光與紅外光輪流照射至該選定皮膚區域上,以具有一紅光期與一紅外光期;接收反射自該皮膚區域上之複數道紅光與複數道紅外光;及分析計算該複數道經反射之紅光與紅外光之光強度,以得到該選定皮膚區域上各座標點之一血氧濃度指數。 The image blood oxygen concentration detecting method of the present invention comprises the steps of: providing a plurality of red and infrared light that alternately appear and uniformly distributed to illuminate a selected skin area of a body of a subject, wherein the selected skin area Having a plurality of coordinate points; controlling the plurality of red and infrared light to be irradiated onto the selected skin area to have a red light period and an infrared light period; receiving a plurality of red light and plural reflected from the skin area Infrared light; and analyzing and calculating the intensity of the reflected light of the red light and the infrared light to obtain a blood oxygen concentration index of each of the coordinate points on the selected skin region.

在較佳實施例中,一白色目標物被當作判定該等入射之紅光與紅外光的比對基礎,整個與上述裝置及方法相關的量測過程係於暗室環境中進行,入射之紅光與紅外光有其較佳入射角度,影像之擷取有其擷取單色光之特點。 In a preferred embodiment, a white object is used as a basis for determining the ratio of the incident red light to the infrared light. The entire measurement process associated with the apparatus and method is performed in a dark room environment, the incident red. Light and infrared light have a better angle of incidence, and the image capture has the characteristics of capturing monochromatic light.

藉由本發明之裝置及方法,帶氧濃度之測量較不受外界訊號強度與人體末稍循環不良之影響。 With the device and method of the present invention, the measurement of the oxygen concentration is less affected by the intensity of the external signal and the poor circulation of the human body.

100‧‧‧影像式血氧濃度檢測裝置 100‧‧‧Image type blood oxygen concentration detecting device

110‧‧‧燈源單元 110‧‧‧Light source unit

111‧‧‧支架組件 111‧‧‧ bracket assembly

112‧‧‧紅光燈組 112‧‧‧Red light group

113‧‧‧紅外光燈組 113‧‧‧Infrared light group

114‧‧‧紅光燈 114‧‧‧Red light

115‧‧‧紅外光燈 115‧‧‧Infrared light

120‧‧‧運算處理單元 120‧‧‧Operation Processing Unit

130‧‧‧影像接收單元 130‧‧‧Image receiving unit

140‧‧‧影像分析/計算單元 140‧‧‧Image Analysis/Computation Unit

150‧‧‧血氧濃度分佈圖建立單元 150‧‧‧ Blood oxygen concentration distribution map building unit

步驟S110‧‧‧發射複數道交替出現並均勻分佈的紅光與紅外光,以照射至一受測者身體之一選定皮膚區域上 Step S110‧‧‧ emits a plurality of alternately and uniformly distributed red and infrared light to illuminate a selected skin area of one of the subjects' bodies

步驟S120‧‧‧控制該複數道紅光與紅外光輪流供應於該選定皮膚區域上 Step S120‧‧‧ controls the plurality of red and infrared light to be supplied to the selected skin area in turn

步驟S130‧‧‧接收反射自該皮膚區域上之複數道紅光與複數道紅外光 Step S130‧‧‧ receiving a plurality of red and multiple infrared rays reflected from the skin area

步驟S140‧‧‧分析並計算該複數道經反射之紅光與紅外光,以得到該選定皮膚區域上各座標點之一血氧濃度指數 Step S140‧‧‧ analyzes and calculates the reflected red and infrared light of the plurality of channels to obtain a blood oxygen concentration index of each coordinate point on the selected skin region

步驟S150‧‧‧建立一血氧濃度分佈圖 Step S150‧‧‧ Establish a blood oxygen concentration profile

以下圖式用以配合本發明之詳細說明,以令熟習該項技術者更得以了解本發明之特點與精神,其中:第1圖為本發明之影像式血氧濃度檢測裝置的方塊示意圖;第2圖為本發明之一燈源單元之一較佳實施例的示意圖;第3圖為本發明之紅光與紅外光之相對於一皮膚區域之入射與反射之相關參數的說明圖;及第4圖為本發明之影像式血氧濃度檢測方法的流程示意圖。 The following drawings are used to clarify the detailed description of the present invention, so that those skilled in the art can understand the features and spirit of the present invention. FIG. 1 is a block diagram of the image blood oxygen concentration detecting device of the present invention; 2 is a schematic view of a preferred embodiment of a light source unit of the present invention; and FIG. 3 is an explanatory diagram of parameters related to incidence and reflection of red light and infrared light with respect to a skin region of the present invention; 4 is a schematic flow chart of the image blood oxygen concentration detecting method of the present invention.

本發明提出一種影像式血氧濃度檢測裝置及方法。現請參照「第1圖」,其為本發明之影像式血氧濃度檢測裝置的方塊示意圖,其中該影像式血氧濃度檢測裝置100包含一燈源單元110、一運算處理單元120、一影像接收單元130、影像分析/計算單元140、及一血氧濃度分佈圖建立單元150。 The invention provides an imaging blood oxygen concentration detecting device and method. Please refer to FIG. 1 , which is a block diagram of the image blood oxygen concentration detecting device of the present invention. The image blood oxygen concentration detecting device 100 includes a light source unit 110 , an operation processing unit 120 , and an image. The receiving unit 130, the image analyzing/calculating unit 140, and a blood oxygen concentration distribution map establishing unit 150.

該燈源單元110包含一支架組件111、一紅光燈組112及一紅外光燈組113。該紅光燈組112包含複數個紅光燈114,該紅外光燈組113包含複數個紅外光燈115,並皆設於該支架組件111上,以求固定,其中紅光燈114與紅外光燈115在「第1圖」中雖顯示個數各為二,但其僅為圖例說明,並非用以限定本發明。該等紅光燈114與紅外光燈115分別交替出現並均勻排列於該燈源單元110上,並在開啟時分別發出紅光與紅外光,以照射至一受測者身體之一選定皮膚區域上。其中,紅光的波長為660±20nm,紅外光的波長為890±20nm,且紅光與紅外光對於皮膚區域的入射角度為75±5°,以避免光線被皮膚表層反射與光線進入真皮層內造成擴散現象產生之干擾。在一較佳實施例中,燈源單元110為一環形構造,此時紅光燈組112之複數個紅光燈114與紅外光燈組113之複數個紅外光燈115沿一環形態勢而交替出現並均勻排列,如「第2圖」所示。為顧及紅光與紅外光投射在受測皮膚區域上的均勻性,燈源單元110係設於受測皮膚區域的正上方。 The light source unit 110 includes a bracket assembly 111, a red light group 112 and an infrared light group 113. The red light group 112 includes a plurality of red light lamps 114, and the infrared light group 113 includes a plurality of infrared light lamps 115, and are disposed on the bracket assembly 111 for fixing, wherein the red light 114 and the infrared light The number of the lamps 115 shown in the "figure 1" is two, but it is only for illustration and is not intended to limit the present invention. The red light 114 and the infrared light 115 alternately appear and are evenly arranged on the light source unit 110, and respectively emit red light and infrared light when illuminated to illuminate a selected skin area of one of the subject's body. on. Among them, the wavelength of red light is 660±20nm, the wavelength of infrared light is 890±20nm, and the incident angle of red light and infrared light to the skin area is 75±5°, to avoid the light being reflected by the skin surface and the light entering the dermis layer. Internal interference caused by the phenomenon of diffusion. In a preferred embodiment, the light source unit 110 has an annular configuration. At this time, the plurality of red light lamps 114 of the red light group 112 and the plurality of infrared light lamps 115 of the infrared light group 113 alternate along a ring shape. Appear and evenly arranged, as shown in Figure 2. To take into account the uniformity of red and infrared light projected onto the area of the skin being tested, the light source unit 110 is positioned directly above the area of the skin being tested.

本發明之裝置100可對一選定皮膚區域之各點皆做測量而得到該些點的血氧濃度測量資料。故,本發明對一加以測量之皮膚區域設以複數個具有座標之點。 The device 100 of the present invention can measure various points of a selected skin region to obtain blood oxygen concentration measurement data for the points. Therefore, the present invention provides a plurality of points having a coordinate to a skin area to be measured.

該運算處理單元120控制該紅光燈組112之紅光燈114與該紅外光燈組113之紅外光燈115同組一前一後輪流開啟,即具有一紅光期與一紅外光期,並各開啟一次即足 夠進行測量。 The operation processing unit 120 controls the red light 114 of the red light group 112 and the infrared light 115 of the infrared light group 113 to be turned on one after the other, that is, have a red light period and an infrared light period. And each time it is turned on It is enough to measure.

該影像接收單元130位於受測皮膚區域的正上方,用以接收反射自該皮膚區域上之複數道紅光與複數道紅外光,並以為一單色影像擷取裝置為更佳。為使所接收得之影像更不受其它外界光的影像,燈源單元110之紅光與紅外光的提供與影像接收單元130的接收經反射紅光與紅外光以在暗室環境中進行最佳。 The image receiving unit 130 is located directly above the tested skin area for receiving a plurality of red light and a plurality of infrared light reflected from the skin area, and is preferably a monochrome image capturing device. In order to make the received image more free from other external light images, the red light and infrared light supply of the light source unit 110 and the image receiving unit 130 receive red light and infrared light for optimal performance in a darkroom environment. .

該影像分析/計算單元140用以分析計算該複數道經反射之紅光與紅外光之光強度,以得到該選定皮膚區域上各座標點之一血氧濃度指數,且係以紅光與紅外光之入射與反射光作為分析的基礎,在較佳實施例中並係以紅光與紅外光之入射與反射的強度作為分析的基礎。此外,本發明之裝置100更包含一白色目標物(未顯示),用以讓紅光與紅外光亦投射其上,以讓影像分析/計算單元140在判定入射之紅光與紅外光之強度時有一參考依據。 The image analysis/calculation unit 140 is configured to analyze and calculate the light intensity of the reflected red light and the infrared light to obtain a blood oxygen concentration index of each coordinate point on the selected skin region, and the red light and the infrared light are The incidence of light and the reflected light are the basis of the analysis. In the preferred embodiment, the intensity of the incidence and reflection of red and infrared light is used as the basis for the analysis. In addition, the apparatus 100 of the present invention further includes a white object (not shown) for projecting red light and infrared light thereon so that the image analysis/calculation unit 140 determines the intensity of incident red light and infrared light. There is a reference basis.

以下將說明影像分析/計算單元140對於入射與經反射紅光與紅外光之計算方式,並請同時參照「第3圖」之說明,其為本發明之紅光與紅外光之相對於一皮膚區域之入射與反射之相關參數的說明圖。 The calculation method of the incident and reflected red and infrared light by the image analysis/calculation unit 140 will be described below, and please refer to the description of "Fig. 3", which is the skin of the red light and the infrared light of the present invention. An illustration of the parameters related to the incidence and reflection of the region.

其中OD為紅光與紅外光之入射與反射時的強度變化,λ為光波長,R’為一含氧血紅素與一缺氧血紅素在該紅光與該紅外 光入射時之光吸收率的比值,ε為光吸收率常數,SpO2為該血氧濃度指數,HbO2為一含氧血紅素的含量,Hb為一缺氧血紅素,C指一物質含量濃度,water是水,other為一水與血紅素以外之物質,k值為該紅光與該紅外光入射該皮膚區域的深度比,I0為該紅光與該紅外光入射時的光強度,I1為一皮膚角質層對該紅光與該紅外光的反射強度,I2為該紅光及該紅外光進入一真皮層反射出來的光強度。公式(1)中,影像接收單元所擷取得之影像包含I1與I2兩者,但I1是不需要的而須被扣除的,而I0也是經由I2及反射率R’反推出,因此也扣除I1。此外,真皮層對入射之光有一擴散作用,故自真皮層反射出來的光I2即為擴散後之反射光。 Where OD is the change in intensity of incident and reflected light of red and infrared light, λ is the wavelength of light, and R' is the light absorptivity of an oxygenated hemoglobin and an anoxic hemoglobin at the incident of the red light and the infrared light. The ratio, ε is the light absorption rate constant, SpO 2 is the blood oxygen concentration index, HbO 2 is the content of an oxygenated heme, Hb is an anoxic hemoglobin, C is a substance concentration, water is water, and so For substances other than water and hemoglobin, k is the ratio of the depth of the red light to the area of the skin into which the infrared light is incident, I 0 is the light intensity at which the red light and the infrared light are incident, and I 1 is a skin keratin The intensity of the reflection of the red light and the infrared light, and I 2 is the intensity of the light reflected by the red light and the infrared light entering a dermis layer. In formula (1), the image obtained by the image receiving unit includes both I 1 and I 2 , but I 1 is not required and must be deducted, and I 0 is also deduced through I 2 and reflectivity R′. Therefore, I 1 is also deducted. In addition, the dermis layer has a diffusing effect on the incident light, so the light I 2 reflected from the dermis layer is the reflected light after diffusion.

此外,當予說明的是,在上述公式(1)中有與角質層相關之參數I1,其可能隨人體膚色變異,目前之公式經實驗知至少適用於黃種人,對於其它人種皮膚可能需要一些影像校正機制。此外,由於紅外光的穿透深度約為1.5mm,而人體皮膚真皮層約厚為1至4mm,因此本發明適用之觀察範圍僅限於淺層皮膚層。 In addition, it should be noted that in the above formula (1), there is a parameter I 1 related to the stratum corneum, which may vary with the skin color of the human body. The current formula is experimentally known to be applicable to at least the yellow species, and may be applied to other human skins. Some image correction mechanism is needed. Further, since the depth of penetration of infrared light is about 1.5 mm, and the thickness of the dermis of human skin is about 1 to 4 mm, the scope of observation applicable to the present invention is limited to the shallow skin layer.

經過實驗,本發明之裝置所能達到的檢測影像解析度為0.04mm,但此不用以限制本發明之範圍。 Through experiments, the detection image resolution that can be achieved by the apparatus of the present invention is 0.04 mm, but this is not intended to limit the scope of the present invention.

在一較佳實施例中,該裝置100更包含一血氧濃度分佈圖建立單元150,可為該運算處理單元控制120控制以對於既分析得之各點座標上血氧濃度構成一血氧濃度圖,以更直接可為醫生與受測者了解受測者的血氧濃度狀態。 In a preferred embodiment, the device 100 further includes a blood oxygen concentration distribution map establishing unit 150, which can be controlled by the arithmetic processing unit 120 to form a blood oxygen concentration for the blood oxygen concentration at each point of the analysis. Figure, in order to more directly understand the blood oxygen concentration status of the subject for the doctor and the subject.

現請參閱「第4圖」,其為本發明之影像式血氧濃度檢測方法的流程示意圖,以下就配合本圖式說明該方法進行的流程。 Please refer to "Fig. 4", which is a schematic flow chart of the image blood oxygen concentration detecting method of the present invention. The flow of the method will be described below in conjunction with this figure.

茲將該影像式血氧濃度檢測方法所包含之步驟詳述如下: The steps involved in the imaging blood oxygen concentration detection method are detailed as follows:

首先,發射複數道交替出現並均勻分佈的紅光與 紅外光,以照射至一受測者身體之一選定皮膚區域上(S110),其中該選定皮膚區域具有複數個座標點。接著,控制該複數道紅光與紅外光輪流照射於該選定皮膚區域上(S120),以具有一紅光期與一紅外光期。繼之,接收反射自該皮膚區域上之複數道紅光與複數道紅外光(S130)。最後,分析並計算該複數道經反射之紅光與紅外光之光強度,以得到該選定皮膚區域上各座標點之一血氧濃度指數(S140)。 First, the red light that alternates and evenly distributes the plurality of rays Infrared light is irradiated onto a selected skin area of one of the subject's body (S110), wherein the selected skin area has a plurality of coordinate points. Then, the plurality of red and infrared light are controlled to be irradiated on the selected skin region in turn (S120) to have a red light period and an infrared light period. Then, a plurality of red lights and a plurality of infrared rays reflected from the skin region are received (S130). Finally, the intensity of the reflected red light and the infrared light of the plurality of channels is analyzed and calculated to obtain a blood oxygen concentration index (S140) of each of the coordinate points on the selected skin region.

與前述說明本發明之裝置者相當,在一些較佳實施例中,該複數道紅光與紅外光係以一環形區域之態勢出現,該紅光期與該紅外光期各為一次。該分析計算該複數道經反射之紅光與紅外光之步驟(S140)係分析計算該複數道經反射紅光與紅外光之光強。在進行該分析計算該複數道經反射之紅光與紅外光的步驟(S140)時,該複數道紅光與紅外光亦照射至一白色目標物上,以作為分析計算該複數道入射之紅光與紅外光的一參考依據。該檢測工作之步驟(S110)與(S130)係於一暗室環境中進行。該接收反射自該皮膚區域上之複數道紅光與複數道紅外光的步驟(S130)中複數道紅光與紅外光的接收係接收純粹單色的紅光與紅外光。該方法更包含一建立一血氧濃度分佈圖的步驟(S150)。該紅光之波長為660±20nm,該紅外光之波長為890±20nm,且該紅光與紅外光之投光角度相對於該選定皮膚區域為75±5°之間。其餘相關敘述亦與前文對本發明之裝置100之說明相當,如本發明之方法可達到的檢測影像解析度為0.04mm,且可單次測量之選定皮膚區域為10cm*10cm大,但不用以限定本發明。 In contrast to the foregoing description of the apparatus of the present invention, in some preferred embodiments, the plurality of red and infrared light rays appear in a ring-shaped region, and the red light period and the infrared light period are each once. The step of calculating the complex reflected red and infrared light (S140) is to analyze and calculate the intensity of the reflected red and infrared light. When performing the analysis to calculate the plurality of reflected red and infrared light (S140), the plurality of red and infrared light are also irradiated onto a white target to calculate the red of the complex incident as an analysis. A reference for light and infrared light. The steps (S110) and (S130) of the detecting operation are performed in a dark room environment. The receiving system that receives the plurality of red and infrared rays reflected from the plurality of red lights and the plurality of infrared rays on the skin region (S130) receives purely monochromatic red and infrared light. The method further includes the step of establishing a blood oxygen concentration profile (S150). The wavelength of the red light is 660±20 nm, the wavelength of the infrared light is 890±20 nm, and the light projection angle of the red light and the infrared light is between 75±5° with respect to the selected skin area. The remaining related descriptions are also equivalent to the description of the apparatus 100 of the present invention. The detection image resolution that can be achieved by the method of the present invention is 0.04 mm, and the selected skin area that can be measured in a single measurement is 10 cm*10 cm, but is not limited. this invention.

此外,該分析計算該複數道經反射之紅光與紅外光的步驟(S140)係以按上述方程式(1)、(2)及(3)計算該複數個座標點的血氧濃度的方式為之,在此省略相同之敘述。 In addition, the step of calculating the complex red and infrared light reflected by the plurality of channels (S140) is to calculate the blood oxygen concentration of the plurality of coordinate points according to the above equations (1), (2) and (3). Here, the same description is omitted here.

本發明之影像式血氧濃度檢測裝置及方法已詳述於上,相較於習用技術,其具有單次操作即得到一皮膚區 域上之血氧濃度分佈資訊、及測量正確性提升的優點與效能。 The image blood oxygen concentration detecting device and method of the present invention have been described in detail above, and have a skin area in a single operation compared with the conventional technology. The information on the distribution of blood oxygen concentration in the domain, and the advantages and effects of improving the correctness of the measurement.

本發明已詳細說明如上,熟習該項技術者已可利用較佳實施例與圖式之配合說明據以實施本發明,然須聲明的是所有在精神上屬於本發明之簡易推衍與變體者,皆當按申請專利範圍之載述視為本發明之範圍。 The present invention has been described in detail above, and those skilled in the art can use the description of the preferred embodiments and the drawings to practice the invention, and all the modifications and variants of the present invention in spirit are claimed. The description of the scope of the patent application is considered to be within the scope of the invention.

100‧‧‧影像式血氧濃度檢測裝置 100‧‧‧Image type blood oxygen concentration detecting device

110‧‧‧燈源單元 110‧‧‧Light source unit

111‧‧‧支架組件 111‧‧‧ bracket assembly

112‧‧‧紅光燈組 112‧‧‧Red light group

113‧‧‧紅外光燈組 113‧‧‧Infrared light group

114‧‧‧紅光燈 114‧‧‧Red light

115‧‧‧紅外光燈 115‧‧‧Infrared light

120‧‧‧運算處理單元 120‧‧‧Operation Processing Unit

130‧‧‧影像接收單元 130‧‧‧Image receiving unit

140‧‧‧影像分析/計算單元 140‧‧‧Image Analysis/Computation Unit

150‧‧‧血氧濃度分佈圖建立單元 150‧‧‧ Blood oxygen concentration distribution map building unit

Claims (13)

一種影像式血氧濃度檢測裝置,包含:一燈源單元,包含一支架組件、一紅光燈組及一紅外光燈組,且該紅光燈組包含複數個紅光燈,該紅外光燈組包含複數個紅外光燈,皆設於該支架組件上,且該等紅光燈與紅外光燈以一環型態勢分別交替出現並均勻排列於該燈源單元上,並在開啟時分別發出紅光與紅外光,自正上方照射至一受測者身體之一選定皮膚區域上,其中該選定皮膚區域具有複數個座標點;一運算處理單元,控制該紅光燈組之紅光燈與該紅外光燈組之紅外光燈輪流開啟,以具有一紅光期與一紅外光期;一影像接收單元,接收反射自該皮膚區域上之複數道紅光與複數道紅外光;及一影像分析/計算單元,分析計算該複數道經反射之紅光與紅外光,以得到該選定皮膚區域上各座標點之一血氧濃度指數,該血氧濃度指數是係按下列方程式計算: 其中OD為紅光與紅外光之入射與反射時的強度變化,λ為光波長,R’為一含氧血紅素與一缺氧血紅素在該紅光與該紅外光入射時之光吸收率的比值,ε為光吸收率常數,SpO2為該血氧濃度指數,HbO2為一含氧血紅素,Hb為一缺氧血紅素,C指一物質含量濃度,water是水,other是一水及血紅素以外之物質,k值為該紅光與該紅外光入射該皮膚區域的 深度比,I0為該紅光與該紅外光入射時的光強度,I1為一皮膚角質層對該紅光與該紅外光的反射強度,I2為該紅光及該紅外光進入一真皮層反射出來的光強度。 An image blood oxygen concentration detecting device comprises: a light source unit, comprising a bracket assembly, a red light group and an infrared light group, and the red light group comprises a plurality of red lights, the infrared light The group includes a plurality of infrared light lamps, which are all disposed on the bracket assembly, and the red light and the infrared light light alternately appear in a ring-shaped state and are evenly arranged on the light source unit, and respectively emit red when turned on. Light and infrared light are irradiated from directly above to a selected skin area of one of the subject's body, wherein the selected skin area has a plurality of coordinate points; an arithmetic processing unit controls the red light of the red light group and the The infrared light of the infrared light group is turned on in turn to have a red light period and an infrared light period; an image receiving unit receives a plurality of red light and a plurality of infrared light reflected from the skin area; and an image analysis / calculating unit, analyzing and calculating the reflected red and infrared light of the plurality of channels to obtain a blood oxygen concentration index of each coordinate point on the selected skin region, wherein the blood oxygen concentration index is calculated according to the following equation: Where OD is the change in intensity of incident and reflected light of red and infrared light, λ is the wavelength of light, and R' is the light absorptivity of an oxygenated hemoglobin and an anoxic hemoglobin at the incident of the red light and the infrared light. The ratio, ε is the light absorption rate constant, SpO2 is the blood oxygen concentration index, HbO2 is an oxyhemoglobin, Hb is an anoxic hemoglobin, C refers to a substance content concentration, water is water, and the other is monohydrate and a substance other than hemoglobin, k is a depth ratio of the red light to the infrared light incident on the skin region, I0 is the light intensity of the red light and the infrared light incident, and I1 is a skin stratum corneum to the red light The intensity of the reflection of the infrared light, I2 is the intensity of the red light and the intensity of the infrared light reflected into a dermis layer. 如申請專利範圍第1項之影像式血氧濃度檢測裝置,其中該影像分析/計算單元係分析計算該複數道紅光與紅外光之光強。 The image blood oxygen concentration detecting device according to claim 1, wherein the image analyzing/calculating unit analyzes and calculates the light intensity of the plurality of red light and infrared light. 如申請專利範圍第1項之影像式血氧濃度檢測裝置,其中該檢測工作係於一暗室環境中進行。 The imaging blood oxygen concentration detecting device of claim 1, wherein the detecting operation is performed in a dark room environment. 如申請專利範圍第1項之影像式血氧濃度檢測裝置,更包含一血氧濃度分佈圖建立單元,且該血氧濃度分佈圖建立單元係由該運算處理單元控制。 The image blood oxygen concentration detecting device according to claim 1 further includes a blood oxygen concentration distribution map establishing unit, and the blood oxygen concentration distribution map establishing unit is controlled by the arithmetic processing unit. 如申請專利範圍第1項之影像式血氧濃度檢測裝置,其中該紅光之波長為660±20nm,該紅光之波長為890±20nm,且該紅光與紅外光之投光角度相對於該選定皮膚區域為75±5°之間。 The image blood oxygen concentration detecting device according to claim 1, wherein the red light has a wavelength of 660±20 nm, the red light has a wavelength of 890±20 nm, and the light projection angle of the red light and the infrared light is opposite to The selected skin area is between 75 ± 5°. 如申請專利範圍第1項之影像式血氧濃度檢測裝置,其中該選定皮膚區域最大可為10cm*10cm。 The image type blood oxygen concentration detecting device of claim 1, wherein the selected skin area is up to 10 cm * 10 cm. 一種影像式血氧濃度檢測方法,包含下列步驟:提供以一環型態勢發射複數道交替出現並均勻分佈的紅光與紅外光,自正上方照射至一受測者身體之一選定皮膚區域上,其中該選定皮膚區域具有複數個座標點;控制該複數道紅光與紅外光輪流入射至該選定皮膚區域上,以具有一紅光期與一紅外光期;接收反射自該皮膚區域上之複數道紅光與複數道紅外光;及分析計算該複數道經反射之紅光與紅外光,以得到該選定皮膚區域上各座標點之一血氧濃度指數,該血氧濃度指數是係按下列方程式計算: 其中OD為紅光與紅外光之入射與反射時的強度變化,λ為光波長,R’為一含氧血紅素與一缺氧血紅素在該紅光與該紅外光入射時之光吸收率的比值,ε為光吸收率常數,SpO2為該血氧濃度指數,HbO2為一含氧血紅素,Hb為一缺氧血紅素,C指一物質含量濃度,water是水,other是一水及血紅素以外之物質,k值為該紅光與該紅外光入射該皮膚區域的深度比,I0為該紅光與該紅外光入射時的光強度,I1為一皮膚角質層對該紅光與該紅外光的反射強度,I2為該紅光及該紅外光進入一真皮層反射出來的光強度。 An image blood oxygen concentration detecting method comprises the steps of: emitting a plurality of alternately and uniformly distributed red and infrared light in a ring-shaped state, and irradiating from a front side to a selected skin area of a body of a subject, Wherein the selected skin region has a plurality of coordinate points; controlling the plurality of red and infrared light to be incident on the selected skin region to have a red light period and an infrared light period; and receiving the plurality of reflections from the skin region a red light and a plurality of infrared rays; and analyzing and calculating the reflected red and infrared light of the plurality of channels to obtain a blood oxygen concentration index of each of the coordinate points on the selected skin region, the blood oxygen concentration index is as follows Equation calculation: Where OD is the change in intensity of incident and reflected light of red and infrared light, λ is the wavelength of light, and R' is the light absorptivity of an oxygenated hemoglobin and an anoxic hemoglobin at the incident of the red light and the infrared light. The ratio, ε is the light absorption rate constant, SpO2 is the blood oxygen concentration index, HbO2 is an oxyhemoglobin, Hb is an anoxic hemoglobin, C refers to a substance content concentration, water is water, and the other is monohydrate and a substance other than hemoglobin, k is a depth ratio of the red light to the infrared light incident on the skin region, I0 is the light intensity of the red light and the infrared light incident, and I1 is a skin stratum corneum to the red light The intensity of the reflection of the infrared light, I2 is the intensity of the red light and the intensity of the infrared light reflected into a dermis layer. 如申請專利範圍第7項之影像式血氧濃度檢測方法,其中該分析計算該複數道經反射之紅光與紅外光之步驟係包含分析計算該複數道經反射紅光與紅外光之光強的步驟。 The image blood oxygen concentration detecting method of claim 7, wherein the step of calculating the reflected red light and the infrared light comprises analyzing and calculating the light intensity of the reflected red light and the infrared light. A step of. 如申請專利範圍第7項之影像式血氧濃度檢測方法,其中該檢測工作係於一暗室環境中進行。 The image blood oxygen concentration detecting method according to claim 7 of the patent application, wherein the detecting work is performed in a dark room environment. 如申請專利範圍第7項之影像式血氧濃度檢測方法,其中該接收反射自該皮膚區域上之複數道紅光與複數道紅外光的步驟更包含接收反射自該皮膚區域上之複數道單色紅光與複數道單色紅外光的步驟。 The image blood oxygen concentration detecting method of claim 7, wherein the step of receiving the plurality of red light and the plurality of infrared rays reflected from the skin region further comprises receiving a plurality of signals reflected from the skin region. The steps of color red light and complex monochromatic infrared light. 如申請專利範圍第7項之影像式血氧濃度檢測方法,更包含一建立一血氧濃度分佈圖的步驟。 For example, the image blood oxygen concentration detecting method of the seventh application patent scope includes a step of establishing a blood oxygen concentration distribution map. 如申請專利範圍第7項之影像式血氧濃度檢測方法,其中該紅光之波長為660±20nm,該紅光之波長為890±20nm, 且該紅光與紅外光之投光角度相對於該選定皮膚區域為75±5°之間。 For example, the image blood oxygen concentration detecting method of claim 7 wherein the wavelength of the red light is 660±20 nm, and the wavelength of the red light is 890±20 nm. And the projection angle of the red light and the infrared light is between 75±5° with respect to the selected skin area. 如申請專利範圍第7項之影像式血氧濃度檢測方法,其中該選定皮膚區域最大可為10cm*10cm。 For example, the image blood oxygen concentration detecting method of claim 7 wherein the selected skin area is up to 10 cm*10 cm.
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