TWI299268B - Shear gel compositions - Google Patents

Shear gel compositions Download PDF

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TWI299268B
TWI299268B TW90127151A TW90127151A TWI299268B TW I299268 B TWI299268 B TW I299268B TW 90127151 A TW90127151 A TW 90127151A TW 90127151 A TW90127151 A TW 90127151A TW I299268 B TWI299268 B TW I299268B
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composition
gel
shear
polymer
hair
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TW90127151A
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Chinese (zh)
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Rupert Telford Brown Charles
Simon Carew Peter
Charles Eklund John
Marcia Evans Jeannette
Fairley Peter
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Unilever Nv
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1299268 A7 B71299268 A7 B7

五、發明説明（ 發明領域 本發明係關於具有增稠流體態之組合物，亦關於其掌法 及其用途。尤其’本發明係關於包括由可用之特殊類=膠 形成之相之組合物，例如整髮組合物及個人梳洗組合物。 背景及先前技藝 ° 懸浮劑 組合物）， 物質之沉 一般係用於各種不同類之組合物中（例如，整髮 以改善安定性，對抗成分之分離’尤其是 降。 整髮組合物中經常用之懸浮劑實例包含結晶懸浮劑（如 二硬脂酸乙二醇酯）及無機結構（如膨潤灰石）。雖然此等物 質對於使顆粒懸浮有效，但對於起泡有負面之影響，且對 組合物造成霧濁之外觀。再者，組合物之使用過程中，會 伴隨期望沉積之成分共沉積，因過度蓬鬆及降低效能造成 頭髮無光澤。 先前技藝亦提出針對懸浮目的使用親水性聚合物，其會 分散在水性劑介質中。天然聚合物已針對此目的使用，尤 其是使用倉耳膠。含倉耳膠之個人梳洗產品，尤其是洗髮 精係述於例如US-A-5286405及GB-A-2188060中，其一問 題為所得產物經常具有無法接受之“黏結，，結構及黏著感。 ,懸浮目的所用之一類合成聚合物為羧基乙烯基聚合物。 羧基乙烤基聚合物為丙烯酸與聚烯丙基蔗糖或聚烯丙基季 t四醇交聯之膠體狀水溶性聚合物，為B F G〇〇drich之商 標CARBOPOL。US 5,635，171揭示-種以該聚合物為準之 透明或半透明凝膠，其中之凝膠係藉由加入極小量之半乳 4 1299268 A7 B7 ) 五、發明説明（2 甘露聚糖（角豆樹、瓜耳膠或刺雲實（tara)膠）硬質化。該硬 質化可使懸浮之相安定化。 然而’其問題為上述類型之叛基乙婦基聚合物並不易調 配’因為特別是其對pH之敏感性及離子強度，及其與以 氧基化界面活性劑之不相容性。 許多水溶液之生物原生體聚合物具有形成所謂可逆凝膠 之能力’例如加熱時會溶化，但在後續冷卻下來後又會回 復為凝膠。形成可逆凝膠之多糖習知之實例為石花菜。含 小％石花菜之水溶液熱時為可流動之液體，但當靜置冷卻 k會形成具有足夠硬質性之凝膠，以保持其自身之形狀。 可形成可逆凝膠之其他天然衍生之聚合物為角叉菜、丹麥 瓊脂、明膠及果膠。 以天然多糖形成之凝膠由聚合物分子之間之作用形成。 可逆之政膠一般在一定溫度範圍中炼化或呈現溶化溫度， 稱之為膠/旋點。該溫度為在緩慢加熱時，會發現溶化使得 其作用大幅度消失之溫度。因此，上述之膠凝點，聚合物 之熱溶液可流動。當冷卻至低於其膠凝點時，聚合物分子 間之作用使其在全部樣品中形成連續及分支之網路。相對 於幵彡成連續分支網路，會使水增稠之部分其他物質僅分子 區域性、過度的糾結。多糖凝膠之討論（包含其機械性質 之範圍）見於Allan H Clark之食品之物理化學，schwartzberg 及Hartel (出版商：Marcel Dekker) 1 992中之“凝膠及膠凝，， 。部分實例中，有遲滯現象且其熔點及凝結溫度並不相同。 减膠之熔化溫度可藉由將直徑約1毫米之鋼球置於完全 -5-V. INSTRUCTIONS OF THE INVENTION (Field of the Invention The present invention relates to compositions having a thickened fluid state, also to their palms and their use. In particular, the present invention relates to compositions comprising phases formed from the special class of gums available, For example, hair styling compositions and personal grooming compositions. Background and prior art ° Suspending agent compositions), the sinking of materials is generally used in a variety of different types of compositions (for example, hair styling to improve stability, combat component separation) 'especially. Examples of suspending agents which are often used in hair styling compositions include crystalline suspending agents (such as ethylene glycol distearate) and inorganic structures (such as bentonite), although such materials are effective for suspending particles. However, it has a negative effect on foaming and causes a hazy appearance on the composition. Further, during use of the composition, the components which are desired to be deposited are co-deposited, and the hair is dull due to excessive fluffiness and reduced efficacy. Previous techniques have also proposed the use of hydrophilic polymers for suspension purposes, which are dispersed in aqueous media. Natural polymers have been used for this purpose, especially The use of urethane earrings. Personal grooming products containing latrine earrings, especially shampoos are described in, for example, US-A-5,286, 405 and GB-A-2188060, the problem being that the resulting product often has an unacceptable "bonding". , structure and adhesion. One type of synthetic polymer used for suspension purposes is a carboxyvinyl polymer. The carboxy b-bake polymer is a colloid of acrylic acid crosslinked with polyallyl sucrose or polyallyl quaternary t-tetraol. A water-soluble polymer, which is a trademark of BFG〇〇drich, CARBOPOL. US 5,635,171 discloses a transparent or translucent gel based on the polymer, wherein the gel is added by adding a very small amount of half-milk 4 1299268 A7 B7 ) V. INSTRUCTIONS (2 Mannan (Carob, Guar or Tara) hardened. This hardening stabilizes the suspended phase. However, the problem is Types of tetamine-based polymers are not readily configurable' because of their sensitivity to pH and ionic strength, and their incompatibility with oxy-chemical surfactants. Many aqueous bio-original polymers Has formed a so-called reversible gel The ability 'is melted, for example, when heated, but returns to a gel after subsequent cooling. An example of a polysaccharide that forms a reversible gel is a broccoli. A small percentage of acacia is a flowable liquid when heated, but When left to cool, k forms a gel with sufficient hardness to maintain its own shape. Other naturally derived polymers that form reversible gels are carrageenan, Danish agar, gelatin and pectin. The gel formed is formed by the action of polymer molecules. The reversible political glue is generally refining or exhibiting a melting temperature in a certain temperature range, which is called a gel/spin point. This temperature is dissolved when slowly heated. The temperature at which the action is largely lost. Therefore, the above gel point, the hot solution of the polymer can flow. When cooled to below its gel point, the interaction between the polymer molecules makes it continuous in all samples. And the network of branches. Compared with the continuous branch network, the other substances that thicken the water are only molecularly regional and excessively entangled. A discussion of polysaccharide gels, including the range of their mechanical properties, can be found in Allan H Clark's Physical Chemistry of Foods, Schwartzberg and Hartel (publisher: Marcel Dekker) 992, "Gel and Gelation," in some examples, There is hysteresis and its melting point and condensation temperature are not the same. The melting temperature of the gel reduction can be achieved by placing a steel ball with a diameter of about 1 mm in the full-5-

A7 B7 1299268 五、發明説明（3 ) 固定之樣品表面上，接著使溫度缓慢上升，例如在水槽中 適當的測量。凝膠熔點為球在樣品上開始下沉之溫度。協 助該測定之裝置係購自例如Anton Paar KG之Physica AMV200 滚球黏度計。 可逆凝膠亦呈現過渡溫度，此時，當溫度緩慢上升時， 所有巨觀或微觀之排列均完全消失。該過渡溫度（由排列 到失序）可藉由差分掃描比熱劑（DSC)測量。以DSC測量之 可逆凝膠過渡溫度以目測一般約與凝膠之熔點相符。 EP-A-3 5 5 90 8膠室可形成可逆凝膠之多糖可用於藉由使 組合物進行剪切，同時形成凝膠，形成黏稠、又可流動之 流體組合物。所得組合物稱之為“剪切凝膠，，。 形成剪切凝膠之另一方式為使用一部份非多糖凝膠之凝 膠。該實例為使用冷凝結之乳狀凝膠，如us 5,217,741中 所述，其係由在pH改變或添加鹽時預形成乳狀凝聚物產 生之凝膠。該冷卻凝結之凝膠可產生與多糖剪切凝膠類似 性質之剪切凝膠。 EP025 0623揭不藉由在高剪切下使乳狀凝膠加熱形成乳 狀顆粒，產生曉得熱凝結顆粒，可用作脂替代 並未以任-物質之包封敛述，但係以具有明顯產出應= 質之流體凝膠敘述。 本發明者發ί見包括由該剪切凝膠形成之連續相組合物不 僅呈現對成分分離及懸浮材料之沉降極佳之抗性，而且可 用於將有利之材料包在凝膠顆粒中。“包住，，係用於敛述並 中有益之物質包在單一凝膠顆粒中之狀態，或其中有益之 -6 -A7 B7 1299268 V. INSTRUCTIONS (3) On the surface of the fixed sample, the temperature is then slowly increased, for example, in a sink. The melting point of the gel is the temperature at which the ball begins to sink on the sample. The device assisting the assay was purchased from a Physica AMV200 ball viscometer such as Anton Paar KG. The reversible gel also exhibits a transition temperature, at which point all macro or microscopic arrangements disappear completely when the temperature rises slowly. The transition temperature (from alignment to out of order) can be measured by differential scanning specific heat (DSC). The reversible gel transition temperature as measured by DSC is generally visually consistent with the melting point of the gel. The EP-A-3 5 5 90 8 gum chamber can form a reversible gel polysaccharide which can be used to form a viscous, flowable fluid composition by shearing the composition while forming a gel. The resulting composition is referred to as a "shear gel." Another way to form a shear gel is to use a portion of a non-polysaccharide gel gel. This example is a milky gel using a condensed knot, such as us. 5,217,741, which is a gel produced by pre-formation of a milky coagulum upon pH change or addition of a salt. The cooled coagulated gel produces a shear gel of similar properties to a polysaccharide shear gel. EP025 0623 It is not disclosed that the milky gel is heated under high shear to form milky granules, and the heat-coagulated granules are produced, which can be used as a lipid substitute without being covered by any substance, but with obvious output. The present invention discloses that the continuous phase composition comprising the sheared gel exhibits excellent resistance to sedimentation of components and sedimentation of suspended materials, and can be used to advantage. The material is encapsulated in the gel particles. "Entrapped, is used to confuse and conducively beneficial to the state of the substance contained in a single gel particle, or which is beneficial -6 -

1299268 A7 B7 五、發明説明（6 ) 相自組合物分離之傾向低^。 發明概要 本發明之第一目的係提供一種具有增稠流體態之組合物 ，包括： (i) 包括至少一種可形成凝膠之聚合物之第一（剪切凝膠） 相，該聚合物係以剪切凝膠（亦即分離凝膠顆粒之多重性 ，其以藉由使聚合物進行剪切，同時發生凝膠形成）存在 於組合物中；及 (ii) 顆粒或液滴態之第二（包封）相，其包括對頭髮有利之 劑類，其中至少部分之顆粒或液滴包封在至少一部份第一 (剪切凝膠）相之凝膠顆粒中。 本發明之第二目的係提供一種製備本發明組合物之方法 ，包括形成聚合物之水溶液，使溶液與一或多種對頭髮有 贫之劑類，但實質上不溶於水溶液中或實質上與水溶液不 相容之顆粒或液滴混合，且使溶液之溫度冷卻至低於形成 凝膠之溫度，同時對組合物施加剪力。 本龟明之第二目的係提供整髮組合物中，在當作基質之 剪切凝膠中使用凝膠顆粒，以控制包封在基質中之物質之 釋出及/或輸送。 ' 較例之詳細砷 蓋一（剪切凝膜μ曰 本文中，“增稠之流體”係用於表示黏度大於水之组合物。 為了使凝膠顆粒在界面活性劑（其 之整髮組合物中）存在下維持穩定， $ —般均存在於本發明 ，因此通常均希望聚合1299268 A7 B7 V. INSTRUCTIONS (6) The tendency to separate from the composition is low. SUMMARY OF THE INVENTION A first object of the present invention is to provide a composition having a thickened fluid state comprising: (i) a first (shear gel) phase comprising at least one gel-forming polymer, the polymer system The shear gel (i.e., the multiplicity of the separated gel particles, which is formed by shearing the polymer while gel formation occurs); and (ii) the particle or droplet state A second (encapsulated) phase comprising a benefit agent for the hair, wherein at least a portion of the particles or droplets are encapsulated in at least a portion of the first (shear gel) phase of the gel particles. A second object of the present invention is to provide a process for the preparation of a composition of the present invention which comprises forming an aqueous solution of a polymer which is incompatible with one or more agents which are deficient in the hair but which are substantially insoluble in the aqueous solution or substantially in contact with the aqueous solution. Incompatible particles or droplets are mixed and the temperature of the solution is allowed to cool below the temperature at which the gel is formed while applying shear to the composition. The second object of the present invention is to provide a hair styling composition in which a gel granule is used in a shear gel as a matrix to control the release and/or delivery of a substance encapsulated in the matrix. 'Comparative example of arsenic cap one (shearing film μ曰), “thickening fluid” is used to mean a composition with a viscosity greater than water. In order to make the gel particles in the surfactant (the whole hair combination) In the presence of a material, it remains stable, and is generally present in the present invention, so it is generally desirable to polymerize

!299268 A7 B7 五、發明説明（7 ) 物在不需多價陽離子下，形成接著可在分子間結合形 膠網之前驅物分子結構。因此，需要可藉由另一種方法^ 成凝膠之聚合物，例如溶解於熱蒸鶴或去礦物質之水中足 夠之/辰度，且使其冷卻至形成凝膠之夠低溫度（例如常溫 或約20 C )。形成凝膠之其他方法包含例如改變pH (例如 形成冷卻凝結之乳狀凝膠）。 與膠凝用之多價陽離子（例如藻朊酸鹽膠及明膠）有關之 聚合物可用於製造凝膠顆粒，及用於整髮組合物，只要其 對界面活性劑安定即可（藉由使用例如保護性結構，如在 凝膠四周或之中之澱粉酵素）。另外，可使用交聯劑使蛋 白質或多糖對凝膠結構上之界面活性劑之破裂作用安定。 本發明之組合物可具有廣泛之黏度。其一例中，組合物 可自由的流動、自動平整及傾倒，但其比水濃稠。另一方 面，其可製成可自摺疊容器壓縮之濃稠液體，但太稠以至 於無法傾倒，除非極慢。 其為剪切變稀，其為整髮組合物如洗髮精及整髮劑有用 之ϋ質，因為使用者對產品感到濃稠及黏稠，但會發覺其 容易施用·。黏稠剪切凝膠之優點為維持擠壓出時之形狀良 好’且因此可以以除簡易傾倒外之方法使用，如由可捲繞 或可變形之擠壓管。 若組合物加熱製溫度超過熔化之溫度，則會使單獨之凝 膠顆粒炫化，且無法在靜止冷卻時再形成分離之顆粒，但 八在叙使用上並不會有問題，因為可逆之凝膠之溶化溫 度通常均超過一般之室溫（例如2〇°c )(不可逆凝膠為無限制 -10 · 本紙張尺度朗中國s家標準(CNS) A4規格(⑽x 297公釐) -- 1299268 A7 B7 五、發明説明（8 ) 之溫度安定，且包含乳狀凝膠）。 本發明組合物之黏度可使用測量其他濃稠液體組合物所 用相同之技術測量。其一適當之裝置為Haake R〇tovisc〇meter>TM ，另一為 Carri-Med CSL 500™黏度計。 本發明之許多組合物在20°C下測量，於10 sec-i之剪切 速率下呈現之黏度範圍為0.1 Pa.s至1〇〇〇 Pa.s。 通常’剪切凝膠相中之凝膠顆粒之平均粒徑（亦即最大 尺寸）在1被米至1000微米間，更好為5微米至微米，且 最好為10微米至80微米，但剪切凝膠相中亦可含粒徑落在 該範圍外之顆粒。 依據本發明之方法製備本發明所需凝膠顆粒之一方法係 以聚合物之水溶液起始，在超過凝膠熔化之溫度（且可能 亦超過其失序之過渡溫度）下，使溶液與一種或多種對頭 髮有益劑類之顆粒或液滴（其為實質的不溶於水溶液中或 與水溶液不互容）混合，接著使溶液冷卻至溫度低於凝膠 凝結之溫度，同時對組合物施加剪切。通常，溶液會施加 剪切，同時自例如比凝膠熔化之溫度高1(rc之溫度^卻至 比形成凝膠之溫度低1(TC至汕艺。 7 小規模之製備可使用燒杯及機械攪拌器進行，在劇烈攪 拌下同時使燒杯中之内容物冷卻。 本發明者傾向於使用刮刀表面熱交換器。此可經裝置在 部分真空中操作，以減少空氣泡在形成凝膠時進入組合物 中。 。 製備凝膠顆粒之另一可能性係使用“攪拌槽，，，其中之溶 -11 - 1299268 A7 B7 五、發明説明（9 ) 液係在裝置溫度計之雙層剪切裝置中驟冷。 另外，剪切凝膠可藉由提供使溶液及添加劑通過平板熱 父換器冷卻形成。平板熱交換器為由如Alfa Laval及apV 2司銷售之習知單元。該裝置中，在溶液通過平板熱交換 裔之通道時會轉化成凝膠。剪切係由於溶液流經熱交換器 通道而傳輸，並非如該申請案先前敘述之方法般以轉子; 輸二使用平板熱交換器製造剪切凝膠可以依再循環模式或 依單-通過模式進行。依再循環模式，溶液自㈣批式槽 之底部泵浦進入平板熱交換器，接著回到攪拌桶中。當槽 中,體溫度到達所需之值（低於聚合物溶液之膠凝點)時^ 止操作。依單-相模式’溶液在自熱交換器離開時會到達 所需溫度。平板熱交換器可以以相對於冷卻介質之流動方 :為同向或逆向模式操作。虽隹然裝置適當之轉向器，但熱 交換器可以以單向或多相構造操#，依特殊應用中所需之 熱轉換效能而定。 平板熱交換器可以與連線之動態 混合裝置（如!299268 A7 B7 V. INSTRUCTION DESCRIPTION (7) The material forms a molecular structure of the precursor before the intermolecular binding of the gel network without the need for polyvalent cations. Therefore, there is a need for a polymer that can be gelled by another method, such as sufficient temperature/density dissolved in hot steamed crane or demineralized water, and allowed to cool to a temperature low enough to form a gel (eg, room temperature) Or about 20 C). Other methods of forming a gel include, for example, changing the pH (e.g., forming a milky gel that cools and condenses). Polymers associated with multivalent cations for gelation (eg, alginate gelatin and gelatin) can be used to make gel particles, and for hair styling compositions, as long as they are stable to the surfactant (by use) For example, protective structures such as amylase around or in the gel). Alternatively, a crosslinking agent can be used to stabilize the rupture of the protein or the polysaccharide against the surfactant on the gel structure. The compositions of the present invention can have a wide range of viscosities. In one example, the composition is free to flow, self-level and pour, but it is thicker than water. On the other hand, it can be made into a thick liquid that can be compressed from a folded container, but too thick to be poured, unless it is extremely slow. It is shear thinning, which is a useful ingredient for hair styling compositions such as shampoos and hair styling agents, because the user feels thick and sticky to the product, but finds it easy to apply. The advantage of a viscous shear gel is that it maintains a good shape when extruded' and can therefore be used in a manner other than simple pouring, such as by a rollable or deformable extruded tube. If the heating temperature of the composition exceeds the melting temperature, the individual gel particles will be dazzled, and the separated particles will not be formed upon static cooling, but there is no problem in the use of the reversible, because reversible condensation The melting temperature of the glue usually exceeds the normal room temperature (for example, 2 ° ° C) (the irreversible gel is unlimited -10 - This paper scales the Chinese standard (CNS) A4 size ((10) x 297 mm) -- 1299268 A7 B7 V. Inventive Note (8) The temperature is stable and contains a milky gel). The viscosity of the compositions of the present invention can be measured using the same techniques used to measure other thick liquid compositions. One suitable device is Haake R〇tovisc〇meter>TM and the other is the Carri-Med CSL 500TM viscometer. Many of the compositions of the present invention exhibited a viscosity ranging from 0.1 Pa.s to 1 Pa Pas at a shear rate of 10 sec-i as measured at 20 °C. Typically, the average particle size (i.e., maximum dimension) of the gel particles in the 'shear gel phase' ranges from 1 to 1000 microns, more preferably from 5 microns to microns, and most preferably from 10 microns to 80 microns, but The shear gel phase may also contain particles having a particle size falling outside of this range. One of the methods for preparing the gel particles of the present invention according to the method of the present invention starts with an aqueous solution of the polymer, and at a temperature above the melting temperature of the gel (and possibly also beyond the transition temperature of its disorder), the solution is treated with one or Mixing a plurality of particles or droplets of the hair benefit agent, which are substantially insoluble or incompatible with the aqueous solution, and then cooling the solution to a temperature below the temperature at which the gel is coagulated while applying shear to the composition . Usually, the solution will apply shear and at the same time, for example, from the temperature at which the gel melts by 1 (the temperature of rc is less than 1 to the temperature at which the gel is formed) (TC to 汕艺. 7 Small-scale preparation can use beakers and machinery The agitator is carried out while simultaneously cooling the contents of the beaker with vigorous agitation. The inventors prefer to use a doctor blade surface heat exchanger. This can be operated in a partial vacuum by means of a device to reduce air bubbles entering the combination when forming a gel. Another possibility for preparing gel particles is to use a "stirring tank," which dissolves -11 - 1299268 A7 B7. 5. Description of the invention (9) The liquid is in a double-layer shearing device of the device thermometer. In addition, the shear gel can be formed by providing a solution for cooling the solution and the additive through a flat heat exchanger. The plate heat exchanger is a conventional unit sold by companies such as Alfa Laval and apV 2. In this device, in solution It is converted into a gel when it passes through the plate heat exchange channel. The shear system is transported as the solution flows through the heat exchanger channel, not the rotor as in the method previously described in the application; The shearing gel can be carried out in a recirculation mode or in a single-pass mode. In the recirculation mode, the solution is pumped from the bottom of the (four) batch tank into the plate heat exchanger and then back to the mixing tank. When the body temperature reaches the desired value (below the gel point of the polymer solution), the operation is continued. In the single-phase mode, the solution will reach the desired temperature when it leaves the heat exchanger. The plate heat exchanger can be used as a relative Flow in the cooling medium: operating in the same or reverse mode. Although the appropriate steering gear is used, the heat exchanger can be operated in one-way or multi-phase configuration, depending on the thermal conversion performance required for the particular application. The flat plate heat exchanger can be connected to the dynamic mixing device (such as

再者，Furthermore,

Silverson 或 Di: 拌槽、刮刀熱 能力。因此， 係藉由含界面活性 且以形成之凝膠顆 本發明者發現許多聚合物凝膠之形成係藉 劑（其一般為整髮組合物之成分）抑制， 粒在後續添加界面活性劑時仍安定。 則一般均希望在實 因此，若最終組合物含界面活性劑， — 本紙張尺度適用中國國家標準(CNS) A4規格(210X 297公釐) 1299268Silverson or Di: Mixing tank, scraper heat capacity. Thus, by the inclusion of interfacial activity and the formation of gel particles, the inventors have discovered that many polymer gel forming agents, which are generally components of hair styling compositions, are inhibited when the surfactant is subsequently added. Still stable. Generally, it is hoped that if the final composition contains a surfactant, the paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 mm) 1299268

貝不έ界面活性劑下’ II由使形成凝膠之聚合物水溶液冷 郃’接著添加界面活性劑形成。另一方法係在剪切下，於 冷卞步驟之前將界面活性劑添加於水性組合物中，但此方 法並非對於所有形成凝膠之聚合物均為可能。 口此本务明之方法可包含製備包括如上述界面活性劑 (如在個人梳洗及整髮組合物中）之組合物之方法，該方法 包括形成聚合物之熱（例如4(rc至100它）、可流動水溶液 ，使溶液與一種或多種實質不溶於水溶液中或與水溶液不 相容之物質之顆粒或液滴混合，使溶液冷卻經過其膠凝溫 度’在冷卻過程中或之後進行冷卻，且在冷卻經過膠凝溫 度之前（較好之後）加入可能之界面活性劑。 本發明者成功使用之實驗室規模刮刀表面熱交換器為購 自西德 ’ Reihen 之 ESCO Labor，CH-4125 之 ESCO Labor™ 混合機。 人造奶油及其他可塗佈食品之商業製造中係使用刮刀表 面熱交換器（A-單元）均質機及溫度控制之針狀-混合機 (C-單元），且該裝置可用於大規模製造本發明之組合物。 該熱交換器之討論見於Harrod之Journal of Food Process Engineering 9 (1986)第1-62頁中。該裝置之供應者包含 Armfield Ltd ， Ringwood ， Hampshire ， England ， Contherm Corporation (為 Alfa-Laval Group，USA之分公 司）及 APV Projects (Crepaco) Ltd，Crawley，West SussexThe beryllium surfactant is formed by cooling the gel-forming polymer aqueous solution followed by the addition of a surfactant. Another method is to add a surfactant to the aqueous composition prior to the cold rolling step under shear, but this method is not possible for all gel forming polymers. The method of the present invention may comprise a method of preparing a composition comprising a surfactant such as the above-described surfactant (e.g., in a personal grooming and hair styling composition), the method comprising forming a heat of the polymer (e.g., 4 (rc to 100) a flowable aqueous solution which is mixed with one or more particles or droplets of a substance which is substantially insoluble in or incompatible with the aqueous solution, allowing the solution to cool through its gelation temperature 'cooling during or after cooling, and The possible surfactant was added before (preferably after) cooling. The laboratory scale scraper surface heat exchanger successfully used by the inventors was ESCO Labor, ESCO Labor, CH-4125, from West Germany' Reihen. TM Mixer. For the commercial manufacture of margarine and other coated foods, a doctor blade surface heat exchanger (A-unit) homogenizer and a temperature controlled needle-mixer (C-unit) are used, and the device can be used for The composition of the present invention is produced on a large scale. A discussion of the heat exchanger is found in Harrod's Journal of Food Process Engineering 9 (1986) on pages 1-62. Comprising Armfield Ltd, Ringwood, Hampshire, England, Contherm Corporation (of Alfa-Laval Group, USA division of the company) and APV Projects (Crepaco) Ltd, Crawley, West Sussex

England 〇 成功的使用以製造本發明剪切凝膠之另一種雙層剪切裝 -13- 本紙張尺度適用中國國家標準(CNS) A4規格(210X 297公复) 1299268 五、發明説明（Μ ) 置為攪拌槽（說明於圖lb)中，其係使用由丁士^ Engineering Limited ^ Solent House > 14 Barnes WallisEngland 〇 Successful use to make another double-layer shearing of the shear gel of the present invention-13- This paper scale is applicable to China National Standard (CNS) A4 specification (210X 297 public) 1299268 V. Invention description (Μ) Set as a stirred tank (described in Figure lb), it is used by Ding Shi ^ Engineering Limited ^ Solent House > 14 Barnes Wallis

Road，Segensworth East，Fareham , Hampshire，P〇5 5TT 供給之Tricool冷卻系統冷卻。 * /咸膠顆粒形成後，界面活性劑或其他成分（可能為液態 濃縮液）之添加可使用一般混合裝置，在低剪切下操作進 行i混合操作應不使組合物加熱至足以造成凝膠顆粒融化 若4要&凝勝顆粒之組合物應在任一後續混合操作之 前及/或過程中冷卻。 出製造蛋白質剪切凝膠之一方法係藉由例如冷卻凝結乳狀 旋膠之方法說明。冷卻凝結之凝膠係以二步驟法製造，第 一步驟包含使蛋白質在不會膠凝但會形成可溶奈㈣性蛋 白質凝聚物之條件下將蛋白質加熱。此通常意指在高或低 p下及沒有鹽之下。；疑聚物係、藉由靜電排斥作用避免凝 :。此等凝聚物接著藉由改變溶液條件，移除該排斥還原 成喊膠。此係藉由添加鹽渡除電荷或改變pH達成。 ^造乳狀剪切凝膠，亦進行該二步驟方法，但第二膠 ^驟係在剪切下進行。該剪切可如前述般以各種方法產 生顆:列7拌槽，，或刮刀表面熱交換器。未使成分包在乳 剪其可在開始加熱步驟前’或在加熱步驟後及在 二刀添加於乳狀溶液中。該添加係藉由使溶液與一 ，或夕種贯質不溶於水性溶液中或與水性溶液不相容之顆 •或液滴混合達成。膠凝經成係藉 、 使溶液在pH為7下變成阳為3.5至/ 誘發，例如 芏〇之間。較好，該改變可 ^張尺^冢標準(CNS) Α·^(21()Χ297公董7 1299268 A7 B7 五、發明説明（12 ) 藉由將酸直接添加於乳漿中，同時在剪切下或藉由添加緩 慢酸化劑，.例如GDL (葡糖酸-5 -内酯）達成，其會緩慢改 變ρ Η同時剪切樣品。 以下將參考附圖詳述本發明中所用物質及程序，其中： 圖1 a為用於製備批式製備剪切凝膠顆粒之實驗適用混合 機之剖面圖， 圖lb顯示用於批式製備剪切凝膠顆粒之另一混合機之剖 面圖。 圖2為圖示的說明連續製備用之裝置； 圖3顯示包在剪切瓊酯凝膠顆粒中之ρ比唆硫_鋅（Ζηρτ〇） 顆粒； 圖4說明本發明之整髮組合物與先前技藝之組合物及 ΖηΡΤΟ未確實包在不同剪切凝膠中，但在瓊酯剪切凝膠顆 粒中為游離之組合物比較，ZnPTO沉積之水準；及 圖5及6分別為含矽酮油液滴之剪切瓊酯凝膠顆粒之低及 高倍放大相片。 圖7顯示包在低凝膠強度之瓊脂剪切凝膠中之石夕酮油。 圖8顯示包封在K-角叉菜（0.5%)剪切凝膠顆粒中之ZnPTO (1%)〇 圖9顯示包封在K-角叉菜（0.5%)剪切凝膠顆粒中之石夕酮 油（0.5%活性，DC2-1669)。 圖10說明製造冷凝結乳衆剪切凝膠顆粒之微同心雙管熱 交換器生產線。 圖la中所示之裝置可為TK AEI均質混合機。其具有聚 -15- 本纸張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 1299268 A7Road, Segensworth East, Fareham, Hampshire, P〇5 5TT Tricool cooling system supplied for cooling. * / After the formation of salty gel particles, the addition of surfactant or other ingredients (possibly liquid concentrate) can be carried out using a general mixing device, operating under low shear for i mixing operations should not allow the composition to heat enough to cause gelation The composition of the particles to be melted should be cooled before and/or during any subsequent mixing operation. One method of producing a protein shear gel is illustrated by, for example, a method of cooling a coagulated milky gel. The cooled coagulated gel is produced in a two-step process, the first step comprising heating the protein under conditions which will not gel but form soluble neat (4) protein agglomerates. This usually means at high or low p and no salt. The suspected polymer system avoids coagulation by electrostatic repulsion: These agglomerates are then reduced to a shim by removing the repulsion by changing the solution conditions. This is achieved by adding a salt to remove the charge or change the pH. The milky shear gel was also subjected to the two-step process, but the second gel was carried out under shear. The shearing can be produced by various methods as described above: column 7 mixing tank, or scraper surface heat exchanger. The ingredients are not packaged in the milk and can be added to the milky solution before the start of the heating step or after the heating step and in the second knife. This addition is achieved by mixing the solution with a droplet, or a droplet, which is insoluble in the aqueous solution or incompatible with the aqueous solution. The gelation is carried out by causing the solution to become positive at a pH of 7 to 3.5 to / induced, for example, between hydrazines. Preferably, the change can be made by a standard (CNS) Α·^(21()Χ297 dongdong 7 1299268 A7 B7 5. Invention description (12) by adding the acid directly to the syrup while at the same time Cut or by adding a slow acidifying agent, such as GDL (glucuron-5-lactone), which will slowly change ρ Η while shearing the sample. The materials and procedures used in the present invention will be described in detail below with reference to the accompanying drawings. , wherein: Figure 1 a is a cross-sectional view of an experimentally suitable mixer for preparing a batch of shear gel particles, and Figure 1b shows a cross-sectional view of another mixer for batch preparation of shear gel particles. 2 is a diagram illustrating the apparatus for continuous preparation; FIG. 3 shows ρ vs. sulphur-zinc (Ζηρτ〇) particles encapsulated in shear agarate gel particles; FIG. 4 illustrates the hair styling composition of the present invention and the prior The composition of the art and the ΖηΡΤΟ are not actually encapsulated in different shear gels, but the level of ZnPTO deposition is compared to the free composition in the agarate shear gel particles; and Figures 5 and 6 are respectively ketone-containing oils. Low and high magnification photographs of the cut agarose gel particles of the droplets. Figure 7 shows the inclusion in the low condensation Figure 7 shows ZnPTO (1%) encapsulated in K-carrageenan (0.5%) shear gel particles. Figure 9 shows encapsulation at K- Carrageenan (0.5%) cuts the sulphuric acid oil (0.5% active, DC2-1669) in the gel particles. Figure 10 illustrates a micro-concentric double-tube heat exchanger production line for the production of condensed nipple shearing gel particles. The device shown in Figure la can be a TK AEI homogenizer with a poly-15-paper scale for the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1299268 A7

1299268 A7 B71299268 A7 B7

圓丄D顯不以以可製适 〜一'、π、乃 刀沈1之用之攪拌 槽。其具有容納室5 (例如玻璃）（例如3〇〇毫升體積），复仓 由其中水自6流到3之溫度套桶7圍燒1 t m = 係經過密封蓋9延伸’且與驅動馬達i相連。檔板8 (例如 以TEFLON™塗覆）自葉片授拌器延伸。溫度探針_ 合物4之溫度。 圖2說明含許多以配管連在一起之獨立設備片之裝置之 較佳形式。 製備聚合物之熱水溶液，且置於供給槽”中。以適者之 管線P1將其自#中輸送到刮刀表面熱交換器^中，：交 換器為圓柱體形式’聚合物溶液流過其間，且由冷卻劑套 桶環繞。該熱交換器中配置大直徑之配置刮刀葉片之二， 其係彈性的配置使其對著圓柱型槽壁之内表面支撐。以馬 達使中心轴轉動時，會對通職交換器A1之聚合物溶液 施加剪力。 當聚合物溶液通過熱交換器A1時，會在剪切條件下冷 卻至其膠凝溫度之下，且導致形成連續相之膠凝顆粒。： 得組5物7熱交換器八丨通到相同但在較低速下操作之第 一熱父換為A2中。此係用於使組合物進一步冷卻。 組合物接著流入混合器C中，其係與單元八丨及八2相同執 行熱交換功能。然❿，在該C-單元中有由熱交換器壁向内 突起之靜止檔板，及馬達驅動中心、小直徑軸心，其會帶 動在圓柱體壁之靜態檔板間之其他檔板。該裝置中沒有刮 刀。組合物在該處與藉由適當泵浦p2|供給槽丁2送進來之 -17-The round 丄D is not used to make a stirrer suitable for the use of ~1, π, and knives. It has a accommodating chamber 5 (for example, glass) (for example, a volume of 3 〇〇ml), and the retort is surrounded by a temperature jacket 7 in which water flows from 6 to 3; 1 tm = is extended through the sealing cover 9' and with the driving motor i Connected. A baffle 8 (e.g., coated with TEFLONTM) extends from the blade agitator. Temperature probe _ the temperature of the compound 4. Figure 2 illustrates a preferred form of apparatus comprising a plurality of individual pieces of equipment joined together by piping. Preparing a hot aqueous solution of the polymer and placing it in the feed tank". It is transported from the # to the scraper surface heat exchanger ^ by the appropriate line P1: the exchanger is in the form of a cylinder in which the polymer solution flows, And surrounded by a coolant jacket. The heat exchanger is provided with a large diameter arrangement of the blade blades, which is elastically arranged to support the inner surface of the cylindrical groove wall. When the motor rotates the central axis, Shear force is applied to the polymer solution of the service exchanger A 1. When the polymer solution passes through the heat exchanger A1, it is cooled under shear conditions to its gelation temperature and causes gelled particles to form a continuous phase. : The group of 7 heat exchangers is passed to the same but the first hot father operating at a lower speed is replaced by A2. This is used to further cool the composition. The composition then flows into the mixer C, It performs the same heat exchange function as the unit gossip and 八2. Then, in the C-unit, there is a static baffle protruding inward from the heat exchanger wall, and a motor drive center and a small diameter axis, which will Drive between the static plates of the cylinder wall Other baffle means is not the doctor blade where the composition is pumped by appropriately P2 |. Butoxy supply tank 2 and send them in the -17-

1299268 A7 --- —_-__B7 五、發明説明（15 ) 界面活性劑溶液混合。離開高速混合器c之混合物為本發 明之組合物。其可在組合物以最終產物輸送之前，或充填 於容器中之前，藉由使其通過另一低速操作之刮刀表面熱 交換器A3中方便的冷卻。 … 泵浦P1及P2可方便的提供比例活塞泵浦之分離通道，其 為確保自各桶ΤΙ、T2輸送一定比例之方便方式。 %如上述裝置中所用之混合裝置、泵浦及刮刀表面熱交換 器均為製造人工奶油及其他可食用塗佈物之常用者。提供 材料流過之結合刮刀表面熱交換器及混合裝置之另一名稱 為“votator，，。此等裝置片可從由可裝置在實驗桌上之小單 疋延伸至大規模製造工廠之尺寸中製造。該裝置之製造廠 包含上述之Armfield Ltd·，Contherm Corporation 及 Apv Projects (Crepaco) Ltd。 其他工廠設計可符合使聚合物溶液經過其膠凝製程冷卻1299268 A7 --- —_-__B7 V. INSTRUCTIONS (15) Mixing of surfactant solution. The mixture leaving the high speed mixer c is a composition of the present invention. It can be conveniently cooled by passing it through another slow speed operation of the blade surface heat exchanger A3 before the composition is delivered as a final product or before being filled in the container. ... Pumps P1 and P2 can easily provide a proportional piston pump separation channel, which is a convenient way to ensure a certain proportion of each barrel and T2. % Mixing devices, pumps and blade surface heat exchangers as used in the above devices are common to the manufacture of artificial creams and other edible coatings. Another name for the combined scraper surface heat exchanger and mixing device that provides material flow is "votator," which can be extended from small singles that can be placed on the bench to large-scale manufacturing plants. The manufacturer of the device includes the above-mentioned Armfield Ltd., Contherm Corporation and Apv Projects (Crepaco) Ltd. Other plants are designed to allow the polymer solution to pass through its gel process cooling.

’同時亦可對所有流體施加實質之剪切力，且均不離本發 明製程之範圍。 X 聚合物種類 本發明之組合物含一種可形成凝膠之聚合物。較好聚合 物應可形成凝膠而不需含溶融之鹽（形成凝膠不可缺少^ 子類之聚合物溶液因界面活性劑而變得不安定，甚至形成 剪切顆^亦然）。通常，此意指在部分濃度為〇 〇4至1〇重 量％下溶於軟水中之該聚合物在自高溫，例如約溶解溫度 冷卻至比形成凝膠之溫度低l〇-2〇r (例如20至90°C 24小 時）。 -18 - 本紙張尺度適财國國家標準(Ci^i格(21GX297公爱)--*~—-— 1299268 A7 B7At the same time, substantial shear forces can be applied to all fluids without departing from the scope of the process of the present invention. X Polymer Type The composition of the present invention contains a gel-forming polymer. Preferably, the polymer should form a gel without the need to contain a molten salt (the formation of a gel is indispensable for the polymer solution of the sub-class to become unstable due to the surfactant, even forming a shearing particle ^). Generally, this means that the polymer dissolved in soft water at a partial concentration of 〇〇4 to 1% by weight is cooled from a high temperature, for example, at a dissolution temperature to a temperature lower than the temperature at which the gel is formed, l〇-2〇r ( For example, 20 to 90 ° C for 24 hours). -18 - This paper scale is suitable for the national standard of the financial country (Ci^i grid (21GX297 public)--*~--- 1299268 A7 B7

五、發明説明（16 該凝膠形成試驗中’聚合物可以或無法在0,04至1〇重量 %之範圍中之各濃度下形成凝膠。對於部分聚合物，可能 無法達到高至10重量％之濃度。部分聚合物可在不需靜置 長達24小時後才形成凝膠。 聚合物較好選自包含多糖、蛋白質及其混合物。更好聚 合物選自角又菜、丹麥瓊脂（furcellaran)、果膠、藻酸趟 、瓊脂、明膠、葡糠甘露聚糖（例如Konjac)、半乳糖、葡 聚糠（例如澱粉、卡德蘭（curdlan)、凝膠、乳漿蛋白質及 其混合物；最好為瓊脂、角叉菜、或乳漿蛋白質。 可形成凝膠之聚合物通常為一種或多種多糖（例如天然 衍生）。 可使用之一種多糖為瓊脂，其當然為用作體外微有機體 之成長介質。 瓊脂糖為直鏈多糠，基本上係由與a_ i半乳糖殘留物 不同之(M，3-半乳糖殘留物組成。前者係以3,6-酸肝存在 ，且為L-對映體。 硫瓊脂同樣具有與α-1，4-半乳糖殘留物不同之(3-13-半乳 糖殘留物，但包含硫酸鹽、丙酮酸鹽及/或葡糖醛酸殘留 物。 4脂一詞涵蓋含瓊脂糖及/或硫瓊脂之聚合物，亦即含 另一 1，3-D-半乳糖及半乳糖殘留物之具有主鏈構造 之聚合物。 瓊脂為特定種類之紅海藻（主要在日本）之萃取物。環脂 之敘述係Tetsujiro Matsuhashi之第一章‘‘食品凝膠，，，由 ________ -19- 本纸張尺度適用中@國家標準(CNS) A4規格(21GX 297公爱) —----- 1299268 A7 B7 五、發明説明（17 )V. INSTRUCTIONS (16) In the gel formation test, the polymer may or may not form a gel at various concentrations ranging from 0,04 to 1% by weight. For some polymers, up to 10 weights may not be achieved. The concentration of %. Part of the polymer can form a gel after not standing for up to 24 hours. The polymer is preferably selected from the group consisting of polysaccharides, proteins and mixtures thereof. The better polymer is selected from the group consisting of horny vegetables and Danish agar ( Furcellaran), pectin, strontium alginate, agar, gelatin, glucomannan (eg Konjac), galactose, glucosinolate (eg starch, curdlan, gel, serum protein and mixtures thereof) Preferably, the agar, carrageenan, or serum protein. The gel-forming polymer is usually one or more polysaccharides (eg, naturally derived). One polysaccharide that can be used is agar, which is of course used as an in vitro micro organism. The agarose is a linear polysaccharide, which is basically composed of a residue of M-3-galactose different from the a-i galactose residue. The former is present as 3,6-acid liver, and is L. - enantiomers. sulfur agar It has a different content from the α-1,4-galactose residue (3-13-galactose residue, but contains sulfate, pyruvate and/or glucuronic acid residues. The term 4 lipid covers agarose-containing And/or a polymer of sulfur agar, that is, a polymer having a main chain structure containing another 1,3-D-galactose and a galactose residue. Agar is an extract of a specific species of red seaweed (mainly in Japan) The description of the ring grease is the first chapter of Tetsujiro Matsuhashi ''Food Gel,,, by ________ -19- This paper scale applies to @国标准(CNS) A4 Specification (21GX 297 公爱) —-- --- 1299268 A7 B7 V. Description of invention (17)

Peter Harris，Elsevier，1990 出版。 可用之另一類多糖為/c角叉菜。角又菜為一類存在於部 分紅海藻類中之多糖。其係由不同之β-1，3-及α-ΐ，4-連結之 半乳糖殘留物組成。1，4 -連結殘留物為D -對映體，且有時 為3，6-酸酐。許多半乳糖殘留物均經硫化。 許多角叉菜結構均已敛述過，且一般之物質為市售，且 接近理想結構。然而，此等結構會依角叉菜之來源及其後 萃取之處理而改變。 不同角叉菜類之敘述見於Norman F Stanley之“角叉菜” ，其為上述“食品凝膠，，之第3章。 /C角又菜係在1，3-連結之半乳糖殘留物上硫化，但並不 在Μ-連結之殘留物上。$角叉菜係在二殘留物上硫化。 λ角叉菜在1，4-連結之殘留物上具有二硫酸鹽基及在7〇0/〇 之1，3-連結之殘留物上具有一硫酸鹽基。 其他類之角又菜可用於具有/C之混合物中。$角又菜之 水溶液以可逆凝膠存在，但此等可自行復原。f角叉菜可 用於形成本發明之組合物，但該組合物在儲存過程中因為 $角又菜凝膠之自行復原性質而變成霧濁，且針對本發明 ’其需要使用λ角叉菜或/c及f之混合物。 λ角又菜在其自身之水溶液中無法形成凝膠，因為其高 的電荷密度抑制分子間之結合，且因此為液態結構。然而 ’部分λ角又菜可包含於具有κ之混合物中，或可以雜質 存在於市售之/C或f角叉菜之供應中。 角又菜混合物中包含λ角叉菜，則該混合物主要（超過Published by Peter Harris, Elsevier, 1990. Another type of polysaccharide that can be used is /c carrageen. Jiaojiao is a kind of polysaccharide that exists in some red seaweeds. It consists of different β-1,3- and α-ΐ,4-linked galactose residues. The 1,4 - linking residue is the D-enantiomer and sometimes the 3,6-anhydride. Many of the galactose residues are vulcanized. Many carrageenan structures have been condensed, and the general materials are commercially available and close to the ideal structure. However, such structures may vary depending on the source of the carrageen and the subsequent extraction process. The description of the different carrageenes is found in Norman F Stanley's "Carrageen", which is the above-mentioned "Food Gel," Chapter 3. /C angles and cuisines are vulcanized on 1,3-linked galactose residues. , but not on the residue of the Μ-link. The horned vine is vulcanized on the two residues. λ carrageen has a disulfate group on the residue of the 1,4-linkage and at 7〇0/〇 The residue of the 1,3-linkage has a sulfate group. Other types of horns can be used in the mixture of /C. The aqueous solution of the horn and the dish exists as a reversible gel, but these can be self-recovering. Carrageenan can be used to form the compositions of the present invention, but the composition becomes hazy during storage due to the self-healing properties of the horny vegetable gel, and for the present invention, it requires the use of lambda carrageen or / a mixture of c and f. The λ angle and the vegetable cannot form a gel in its own aqueous solution because its high charge density inhibits the intermolecular bond and is therefore a liquid structure. However, the 'partial λ angle can be included in the In a mixture of κ, or impurities may be present in commercially available /C or f carrageen In the supply. The mixture of horn and vegetable contains λ carrageen, then the mixture is mainly (more than

1299268 A7 B7 五、發明説明（19 ) 速率及不同之轉子速度使顆粒分散液均勻、懸浮之性質及 黏度為最佳’可能係由於凝膠顆粒形狀可能在球形及片狀 間改變。 韭界面活性劑f；鮮質 雖然通常均希望聚合物應可在不加入離子性物種下形成 凝膠，但部分聚合物可在蒸餾水或軟水中形成凝膠，而且 ’若含有部分電解質，則會形成黏度較大之電解質。應注 意/C角叉菜凝膠分散液之黏度會因鉀離子之存在而增加， 且瓊脂凝膠分散液之黏度會在鈣離子存在下增加。因此， 在男切下冷卻形成本發明所需凝膠顆粒之聚合物溶液包含 電解質以提昇所得凝膠顆粒之強度。所需電解質之量可為 產物之小百分比，例如1 %。 篇二（包封）相 本發明組合物中之包封相可包含任一種通常希望加在組 σ物中之對頭髮有益之劑類。較好，包封相之材料在組合 物中需要某種程度之安定，以避免相分離及在一般儲存條 件下沉降，或與其他調配成分分離之效益，或在包封時提 幵輸送之效益。 包封相為不可;;谷固體之顆粒或不互溶液體之液滴（其至 >邛刀包封在凝膠顆粒中）形式。較好，組合物中至少π 重i /〇,更好至少75重量。/〇，最好95重量％之不可溶固體 或不互溶液體包封在凝膠顆粒中。凝膠顆粒可含平均一顆 粒或一液滴之包封相，或較好許多顆粒或液滴。顆粒或液 滴亦可與凝膠顆粒之外表面結合，但基本上其至少部分在 L_______ -22- 本紙張尺度適财S g家標準(⑽）Μ規格(2綱挪公董)------ 1299268 五 發明説明 A7 B7 組合物中所述之調整劑、修飾劑及固態活化劑之一或多種 。相對的，可有利的用於皮膚之固體及/或液體活性物質 均可加於本發明之個人洗滌組合物中。 、 11^處理組合物 較好，本發明之組合物為頭髮處理組合物且包封相及若 存在之第三懸浮相為選自下列物質類之一種或多種之對頭 髮有利之劑類。 、 至於本文中所用之“調整劑，，一詞包含可用於對頭髮及/ 或皮膚提供特殊調理效益之物質。例如，洗髮所用組合物 如洗髮糈及潤濕精適用之物質為可對陽光、柔軟度、可梳 理性、潤濕處理、抗靜電性、保護免於受損、身體、體積 、造型性及易處理性提供一種或多種效益者。 本發明中所用較佳調整劑包含乳化之石夕嗣、用於對頭髮 賦予例如濕潤及乾燥調整效益，如柔軟度、平順感及易梳 理性。 製造本發明中所用矽酮顆粒乳液之各種方法均可使用且 為熟習本技藝者所習知。 石夕_本身（非為乳液或最終之洗條組合物）之黏度較好在 10000 cps至5百萬cps之間。黏度可使用凝膠虹吸黏度計， 如1970年7月20日之道康寧公司試驗方法CTM004中進一步 說明。 適當之矽酮包含聚二有基矽酮，尤其是聚二甲基石夕酮， 其具有 Cosmetics & Toiletries formulatory Association (CTFA) -24- 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 1299268 A7 ______B7 _五、發明説明（22~Γ 所稱之一曱矽酮。貫例為25。(：下之黏度達1〇〇,〇〇〇浬按之 二甲矽酮流體，其係購自通用電器公司之viscasilTM系列 ，及道康寧之DC 20〇tm系列。 具有CTFA所稱胺基甲矽酮之胺基官能基矽酮亦適用於 本發明之組合物，例如具有羥基端基之聚二甲基矽酮，其 具有CTFA所稱之二甲矽酮醇。 亦適用指為矽酮膠。“矽酮膠，，代表分子量2〇〇,〇〇〇至 1，000,000之聚二有機矽氧烷，且特殊實例包含二甲矽酮膠 、二甲矽酮醇膠、二甲基矽氧烷/二苯基/甲基乙烯基矽氧 烷共聚物，聚二曱基矽氧烷/甲基乙烯基矽氧烷共聚物及 其混合物。實例包含美國專利第中及 通用電器矽酮橡膠產物數據SE 3〇，SE 33，se 54及SE 76 所述之物質。 本發明中亦適用者為稍微交聯之矽酮膠，如實例 W096/3 1 188中所述。此等物質可賦予頭髮形體、體積及 造型性’以及良好之潤濕及乾燥調整。 本發明組合物中所用較佳之乳化矽酮在組合物中之平均 矽酮顆粒粒徑低於100 ,較好低於30，更好低於2〇微米， 但較好低於10微米。 粒仏了藉由苗射光知描技術，使用Maivern儀器之26〇〇d 粒徑計測量。 本發明中適用之矽酮乳化劑係以預乳化態購得。此為最 佳因為預形成之乳液可以以簡單之混合加於洗 )條組合物中。 適用之預形成乳液實例包含乳液DC2-1766及DC2-1784 -25- 本纸張尺度適用巾s a家標準(CNS) Μ規“ίο X挪公釐_) 1299268 A7 B7 五、發明説明（23 ’講自道康寧。此等為乳液及二甲矽酮醇。交聯之發綱膠 亦以與乳化態銷售，其對於容易調配有利。較佳之實例> 購自道康寧DCX2-1787之物質，其為交聯之二甲矽_醇^ 之乳液。 > 加於本發明組合物中之矽酮量依期望之調整水準及所用 物質而定。較佳之量為全部組合物之〇·〇 i至約i 〇重量％， 但此等限制並非絕對。下限係由達到調整之最小量而定， 且上限係以避免造成頭髮及/或皮膚無法接受之油腻狀之 最大量。本發明者發現矽酮之量為總組合物之0 5至15重 Ί %為最適用之量。 另一較佳之調整劑種類為過烷（烯）基烴物質，用於提昇 頭髮之形體、體積及造型性。 EP 567 326及EP 498 1 19敘述賦予頭髮造型性且提昇形 體之適用過烷（烯）基烴物質。較佳之物質為購自Presperse 公司商標PERMETHYL之聚異丁烯基物質。 本發明組合物中所加之過烷（烯）基烴物質依期望提昇之 形體及體積水準及所用特殊物質而定。較佳之量為全部組 合物之0·01至約10重量％，但此等限制並非絕對。下限係 由達到形體及體積作用之最小量測定，且上限係避免造成 頭髮無法接受之剛硬之最大量。本發明者發現過烷（烯）基 烴物質之最適量為全部組合物之〇,5至2重量％。 固態活化劍 一般固態活化劑之實例包含抗菌劑，如吡啶硫酮（亦已 知為％比硫酮”）之重金屬鹽，尤其是鋅说咬硫酮，及其他 -26- 本紙張尺度適用中國國家標準(CNS) A4規格(21〇 X 297公釐) I2992681299268 A7 B7 V. INSTRUCTIONS (19) Velocity and different rotor speeds make the particle dispersion uniform and suspend properties and viscosity optimal. Depending on the shape of the gel particles, it may vary between spheres and flakes.韭activator f; fresh, although it is generally desirable for the polymer to form a gel without the addition of ionic species, some polymers can form a gel in distilled or soft water, and 'if there is a part of the electrolyte, Form an electrolyte with a high viscosity. It should be noted that the viscosity of the /C carrageenan gel dispersion increases due to the presence of potassium ions, and the viscosity of the agar gel dispersion increases in the presence of calcium ions. Therefore, the polymer solution which is cooled by the male cut to form the gel particles required in the present invention contains an electrolyte to increase the strength of the obtained gel particles. The amount of electrolyte required can be a small percentage of the product, for example 1%. The second (encapsulated) phase of the encapsulated phase of the compositions of the present invention may comprise any of the agents which are generally desired to be added to the group σ which are beneficial to the hair. Preferably, the material of the encapsulating phase requires some degree of stability in the composition to avoid phase separation and sedimentation under normal storage conditions, or the benefit of separation from other formulated ingredients, or the benefit of transport during encapsulation. . The encapsulated phase is incapable; the form of the grain of the grain solid or the droplet of the immiscible liquid (which is encapsulated in the gel particles by the > file). Preferably, the composition has at least π weight i / 〇, more preferably at least 75 weight. / 〇, preferably 95% by weight of the insoluble solid or immiscible body is encapsulated in the gel particles. The gel particles may contain an average of one or a droplet of the encapsulated phase, or preferably a plurality of particles or droplets. The particles or droplets may also be combined with the outer surface of the gel particles, but basically at least in part at L_______ -22- This paper scale is suitable for the standard of the product ((10)) Μ specification (2 ganggong Dong)--- --- 1299268 Five Inventions One or more of the modifiers, modifiers, and solid activators described in the A7 B7 compositions. In contrast, solid and/or liquid active materials which may be advantageously applied to the skin may be added to the personal cleansing compositions of the present invention. Preferably, the composition of the present invention is a hair treatment composition and the encapsulated phase and, if present, the third suspension phase are those which are advantageously selected from one or more of the following classes. As used herein, the term "adjusting agent" encompasses substances that can be used to provide special conditioning benefits to the hair and/or skin. For example, compositions for shampoos such as shampoos and moisturizers are suitable. Sunlight, softness, combability, wetting treatment, antistatic properties, protection from damage, body, volume, styling and ease of handling provide one or more benefits. The preferred conditioning agent used in the present invention comprises emulsification The stone is used for imparting moistening and drying adjustment benefits to the hair, such as softness, smoothness and combability. Various methods for producing the indolone granule emulsion used in the present invention can be used and are familiar to those skilled in the art. The skating _ itself (not the emulsion or the final shampoo composition) has a viscosity of between 10,000 cps and 5 million cps. The viscosity can be obtained using a gel siphon viscometer, such as July 20, 1970. The method is further described in Corning's test method CTM004. Suitable anthrones include polydithioxanthone, especially polydimethyl ketone, which has Cosmetics & Toiletries formulatory Associatio n (CTFA) -24- This paper scale applies to Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1299268 A7 ______B7 _ V. Description of invention (22~Γ One of the known ketones. The case is 25 (: The viscosity is up to 1〇〇, according to the dimethyl ketone fluid, which is purchased from General Electric's viscasilTM series, and Dow Corning's DC 20〇tm series. Amino ketone-based functional fluorenone is also suitable for use in the compositions of the present invention, such as polydimethyl fluorenone having a hydroxyl end group, which has the dimethyl ketone ketone referred to by CTFA. "Anthrone rubber, which represents a molecular weight of 2 〇〇, 〇〇〇 to 1,000,000 polydiorganotoxime, and special examples include dimethyl ketone gum, dimethyl ketone ketone, dimethyl oxime Alkyl/diphenyl/methylvinylaluminoxane copolymer, polydidecyloxane/methylvinyloxirane copolymer and mixtures thereof. Examples include U.S. patents and general purpose electrical anthrone rubber products. The materials described in the data SE 3〇, SE 33, se 54 and SE 76. Also suitable for use in the present invention are slightly crosslinked ketone gums. As described in Example W096/3 1 188. These materials impart hair shape, volume and shapeability as well as good wetting and drying adjustment. The preferred emulsified fluorenone used in the compositions of the present invention is in the composition. The average fluorenone particle size is less than 100, preferably less than 30, more preferably less than 2 〇 micrometers, but preferably less than 10 micrometers. The granules are processed by the ray-lighting technique, using the Maivern instrument 26 〇〇 d Particle Size Measurement The fluorenone emulsifier suitable for use in the present invention is commercially available in a pre-emulsified state. This is preferred because the preformed emulsion can be added to the wash strip composition in a simple blend. Examples of suitable pre-formed emulsions include emulsion DC2-1766 and DC2-1784 -25- This paper scale applies to the towel sa standard (CNS) Μ “ ί ίο X 公 _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Speaking from Dow Corning. These are emulsions and dimethyl ketone alcohol. Crosslinked gluten is also sold in an emulsified state, which is advantageous for easy blending. Preferred Examples> Materials purchased from Dow Corning DCX2-1787, which are An emulsion of cross-linked dimethylhydrazine-alcohol. > The amount of fluorenone added to the composition of the present invention depends on the desired level of adjustment and the substance used. The preferred amount is 〇·〇i to about the entire composition. i 〇% by weight, but these limits are not absolute. The lower limit is determined by the minimum amount of adjustment, and the upper limit is to avoid the maximum amount of greasy shape that is unacceptable to the hair and/or skin. The amount is from 0 to 15 weight % of the total composition is the most suitable amount. Another preferred type of modifier is a peralkyl (alkenyl) hydrocarbon material for enhancing the shape, volume and shape of the hair. 326 and EP 498 1 19 describe the application of hair styling and lifting of the body An alk(en)yl hydrocarbon material is used. Preferred materials are polyisobutylene based materials available from Presperse Corporation under the trademark PERMETHYL. The form and volume level of the peralkyl (alkenyl) hydrocarbon material added to the composition of the present invention is desired to be improved. The preferred amount is from 0. 01 to about 10% by weight of the total composition, but the limits are not absolute. The lower limit is determined by the minimum amount of effect on the body and volume, and the upper limit is to avoid hair loss. The inventors have found that the optimum amount of alk(en)yl hydrocarbon material is from 5% to 2% by weight of the total composition. Solid State Activated Sword Generally examples of solid activators include antibacterial agents, such as Heavy metal salts of pyrithione (also known as % thione), especially zinc thiones, and other -26- paper scales applicable to China National Standard (CNS) A4 specification (21〇X 297 mm) ) I299268

抗囷劑如甘寶素、碎l ”比咬酮乙醇胺鹽”比咬綱胺基乙醇 鹽、二硫化硒及酮康唑。此等物質之平均粒徑一般約〇.2 至50微米’較好為〇·4至約1〇微米。此等固體活化劑為包 封相之較佳物質。雖然物質可對皮膚及/或頭皮屑作用， 但熟習本技藝者應了解其可用於處理頭皮屑（例如抗頭皮 屑洗髮精）用之頭髮處理組合物，且係包封在“對頭髮有益 之劑類’’中，如本文中所用。 當固態活化劑為抗菌劑時，如鋅吡交硫酮，其適用於本 ^明中之篁為全部組合物之〇 0 0丨％至約1重量％。 其他適用之固態活化劑包含顏料顆粒，如用於頭髮之固 ^染料或著色劑及金屬膠體。 1化劑 頭髮處理組合物如洗髮精及潤濕精及部分個人洗滌組合 物通常為霧濁狀或珍珠色，以提昇對消費者之吸引力。 霧濁化劑之實例包含高級脂肪醇（例如十四烷基、硬脂 基、一十烷基及二十二烷基）、固態酯（例如棕櫚酸十四烷 酯、月桂酸甘油酯、MEA-硬脂酸硬酯醯胺）、高分子量脂 肪醯胺及烷醇醯胺及各種脂肪酸衍生物，如丙二醇及聚乙 二醇酯。用於使頭髮處理組合物霧濁之無機物質包含矽酸 鎂鋁、氧化鋅及二氧化鈦。 珍珠光澤劑一般會在組合物中形成薄，片狀結晶，其形 同為微小之鏡面。上面所列之部分霧化劑亦可能結晶成為 珍珠光澤劑，依其所用介質及所用條件而定。 一般之光澤劑可能選自C16-C22脂肪酸（例如硬脂酸、 __ -27- 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 1299268 A7 B7 五、發明説明（25 ) 四烷酸、油酸、及二十二烷酸），C16-C22脂肪酸與醇之酯 類及加入如烷二醇單元元素之C16-C22脂肪酸之酯類。適 用之烷二醇單元包含乙二醇及丙二醇。 然而，可使用較高伸烷基鏈長之二醇。適用之較高伸烷 基鏈長二醇包含聚乙二醇及聚丙二醇。 實例為具有1至7個環氧乙烷單元之C16-C22脂肪酸之聚 乙二醇單或雙二酯，及C16-C22脂肪酸之乙二醇酯。較佳 之酯類包含聚乙二醇二硬脂酸酯及乙二醇二硬脂酸酯。市 售聚乙二醇二硬脂酸酯之實例為EUPERLAN PK900 (例如 Henkel)或 GENAPOL TS (例如 Hoechst)。一 乙二醇二硬脂 酸酯之實例為EUPERLAN PK3000 (例如Henkel)。 其他珍珠光澤劑包含具有16至2 2個碳原子之脂肪酸之烧 醇醯胺（例如硬脂酸單乙醇醯胺、硬脂酸二乙醇醯胺、硬 脂酸單異丙醇醯胺及硬脂酸單乙醇醯胺）；長鏈脂肪酸之 長鏈S旨類（例如硬脂酸硬脂S旨、稼禍酸十四烧醋）；甘油S旨 (例如二硬脂酸甘油酯）、長鏈烷醇醯胺之烷醇酯類（例如硬 脂醯胺DEA二硬脂酸酯、硬脂醯胺MEA硬脂酸酯）及烷基 (C18-C22)二甲基胺氧化物（例如硬脂基二甲基胺氧化物）。 另一適用之珍珠光澤劑包含無機材料如以天然礦物雲母 為主之珍珠質顏料。實例為塗覆二氧化鈦之雲母。該材料 之粒徑為2至150微米。通常，粒徑較小可提升珍珠外觀， 且具有較大平均直徑之顆粒會造成閃爍組合物。 適用之塗覆二氧化鈦之雲母為以商標TIMIRON (merck) 或 FLAMENCO (Mead)銷售者。 -28- 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐）Anti-caries agents such as gamma sulphate, squid l" ketone ethanolamine salt" than bite amine ethoxide, selenium disulfide and ketoconazole. The average particle size of such materials is generally from about 2 to 50 microns', preferably from about 4 to about 1 inch. These solid activators are preferred materials for the encapsulated phase. While the substance may act on the skin and/or dandruff, those skilled in the art will appreciate that it can be used to treat dandruff (e.g., anti-dandruff shampoo) hair treatment compositions, and is encapsulated in "good for hair." In the agent class, as used herein. When the solid activator is an antibacterial agent, such as zinc pyrithione, it is suitable for use in the present invention as 全部0% to about 1 of the total composition. Other suitable solid activators include pigment particles, such as solidifying dyes or colorants for hair and metal colloids. 1 Hair treatment compositions such as shampoos and moisturizers and some personal cleansing compositions are usually It is hazy or pearly to enhance the appeal to consumers. Examples of haze agents include higher fatty alcohols (such as tetradecyl, stearyl, decadecyl and behenyl), Solid esters (such as tetradecyl palmitate, lauric acid glyceride, MEA-stearyl decylamine), high molecular weight fatty guanamines and alkanolamines and various fatty acid derivatives such as propylene glycol and polyethylene glycol Ester. Used to make hair treatment composition fog The turbid inorganic substance contains magnesium aluminum silicate, zinc oxide and titanium dioxide. The pearl luster generally forms a thin, flaky crystal in the composition, which is similar to a tiny mirror. Some of the atomizing agents listed above may also crystallize. Become a pearlescent agent, depending on the medium used and the conditions used. The general gloss agent may be selected from C16-C22 fatty acids (eg stearic acid, __ -27- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1299268 A7 B7 V. INSTRUCTIONS (25) Tetraic acid, oleic acid, and behenic acid), esters of C16-C22 fatty acids and alcohols, and C16- added to elements such as alkanediol. Esters of C22 fatty acids. Suitable alkanediol units include ethylene glycol and propylene glycol. However, higher alkyl chain length diols can be used. Suitable higher alkyl chain long diols contain polyethylene glycol. And polypropylene glycol. Examples are polyethylene glycol mono- or di-diesters of C16-C22 fatty acids having 1 to 7 ethylene oxide units, and ethylene glycol esters of C16-C22 fatty acids. Preferred esters include polyethylene. Glycol distearate and ethylene glycol distearate. Examples of polyethylene glycol distearate sold are EUPERLAN PK900 (e.g. Henkel) or GENAPOL TS (e.g. Hoechst). An example of monoethylene glycol distearate is EUPERLAN PK3000 (e.g. Henkel). Other pearlescent agents An alkaloid containing a fatty acid having 16 to 22 carbon atoms (for example, monoethanolamine stearate, diethanolamine stearate, monoisopropanol stearate and monoethanolate stearate) Amine); long-chain S of long-chain fatty acids (such as stearic acid stearic acid, sulphuric acid, sulphuric acid); glycerol S (for example, glyceryl distearate), long-chain alkanolamine Alkanol esters (eg, stearylamine DEA distearate, stearylamine MEA stearate) and alkyl (C18-C22) dimethylamine oxides (eg, stearyl dimethyl) Amine oxide). Another suitable pearlescent agent comprises an inorganic material such as a pearl pigment mainly composed of natural mineral mica. An example is titanium dioxide coated mica. The material has a particle size of from 2 to 150 microns. Generally, smaller particle sizes increase the appearance of the pearl, and particles having a larger average diameter can cause a scintillating composition. Suitable titanium dioxide coated mica is sold under the trademark TIMIRON (merck) or FLAMENCO (Mead). -28- This paper scale applies to Chinese National Standard (CNS) A4 specification (210 X 297 mm)

裝 訂Binding

線 1299268Line 1299268

發明説明 本發明組合物中所用霧濁 部組合物之〇·〇1至20%，較 量％ 〇 劑或珍珠光澤劑之量一般為全 好0·01至5%，更好0.02至2重 氣體（例如空氣）氣泡代表另—類可加在針對美觀目的之 、髮處理、、且合物中之懸浮相。當均勾之顆粒及均勻分散在 組合物中_，此等可提升對消費者之吸引力一般之應用 為透明或半透明之組合物，如造型髮膠。 本^月之頭髮處理組合物可經調配成透明或霧濁之乳液 化妝水、礼霜、糊料或凝膠。最佳之產物形式為洗髮精 、潤濕精及造型髮膠。 洗备精組合物 本發明最佳之頭髮處理組合物為洗髮精組合物。 該洗髮精可包含一種或多種在保養上可接受且適用於頭 髮局部使用之清潔介面活性劑。若組合物中之任一乳化成 分之乳化劑，例如乳化之矽酮無法提供足夠之清潔目的， 則可使用額外成分之其他介面活性劑。較好本發明之洗髮 精、，且s物包括至少一種其他介面活性劑（除所用之乳化劑 外），以得到清潔效益。 適用之清潔介面活性劑（可單獨使用或合併使用）係選自 陰離子、兩性離子及兩性介面活性劑，及其混合物。清潔 介面活性劑可為與乳化劑相同之介面活性劑或可為不同^ 陰離子界面活性劑之實例為烷基硫酸鹽、烷基醚硫酸鹽 、烷芳基〜酸鹽、烷醯基異硫酮酸酯、烷基丁二酸鹽、烷 -29-DESCRIPTION OF THE INVENTION The haze portion composition used in the composition of the present invention has a 〇·〇1 to 20%, and the amount of the tanning agent or the pearl luster is generally from 0. 01 to 5%, more preferably from 0.02 to 2 by weight. (e.g., air) bubbles represent additional phases that can be added to the aesthetics, hair treatments, and suspension phases. When the particles are evenly dispersed in the composition, these can enhance the appeal to consumers. Generally, the application is transparent or translucent, such as styling hair gel. The hair treatment composition of the present month can be formulated into a transparent or turbid lotion lotion, ritual cream, paste or gel. The best product forms are shampoo, moisturizer and styling hair gel. Hair Care Composition The hair treatment composition of the present invention is a shampoo composition. The shampoo may comprise one or more cleansing surfactants that are acceptable in maintenance and suitable for topical use in hair. If the emulsifier of any of the emulsified components of the composition, such as emulsified fluorenone, does not provide sufficient cleaning, other surfactants of the additional ingredients may be used. Preferably, the shampoos of the present invention, and the s include at least one other surfactant (in addition to the emulsifier used) to provide a cleaning benefit. Suitable cleansing surfactants, either alone or in combination, are selected from the group consisting of anionic, zwitterionic and amphoteric surfactants, and mixtures thereof. The cleansing surfactant may be the same surfactant as the emulsifier or may be different. Examples of anionic surfactants are alkyl sulfates, alkyl ether sulfates, alkylaryl-acid salts, alkyl alkane isothiones. Acid ester, alkyl succinate, alkane-29-

1299268 A7 B7 五、發明説明（27 ) 基硫丁二酸鹽、N-烷基肌胺酸酯、烷基磷酸鹽、烷基醚磷 酸鹽、烷基醚羧酸鹽、及α -烯烴磺酸鹽，尤其是其鈉、 鎂、胺及單-、二-及三乙醇胺鹽。烷基及醯基一般含8至 1 8個碳原子，且可為不飽和。烷基醚磺酸鹽、烷基醚磷酸 鹽及烷基醚羧酸鹽之每分子可含1至10個環氧乙烷或環氧 丙烧。 本發明之洗髮精中所用之一般陰離子界面活性劑包含油 基丁二酸鈉、月桂基硫丁二酸胺、月桂基硫酸胺、十二烷 基苯磺酸鈉、三乙醇胺十二烷基苯磺酸鹽、可可基異硫酮 酸鈉、月桂基異硫_酸納及Ν -月桂基基胺酸鈉。最佳之陰 離子界面活性劑為月桂基硫酸鈉、三乙醇胺單月桂基鱗酸 鹽、月桂基醚硫酸鈉1ΕΟ、2ΕΟ、及3ΕΟ、月桂基硫酸胺 及月桂基醚硫酸胺1ΕΟ、2ΕΟ及3ΕΟ。 兩性及兩性離子介面活性劑之實例包含烷基胺氧化物、 烧基甜菜驗、烧基酿胺基丙基甜菜驗、烧基硫基甜菜驗 (sultaines)、胺基乙酸烷酯、羧基胺基乙酸烷酯、樟腦丙 酸烷酯、樟腦甘油酸烷酯、醯胺基丙基羥基硫基甜菜鹼、 醯基酒石酸鹽及醯基葡糖酸鹽，其中之烷基及醯基均具有 8至19個碳原子。本發明之洗髮精中所用一般兩性及兩性 離子界面活性劑包含月桂基胺氧化物、可可二甲基硫基丙 基甜菜鹼，且較好為月桂基甜菜鹼、可可醯胺基丙基甜菜 驗及可可樟腦丙酸鈉。 洗髮精組合物亦可包含共介面活性劑以協助賦予洗髮精 美觀、物理或清潔性質。較佳實例為非離子性介面活性劑 -30- 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公 1299268 A71299268 A7 B7 V. INSTRUCTIONS (27) Thio-succinate, N-alkyl sarcosinate, alkyl phosphate, alkyl ether phosphate, alkyl ether carboxylate, and α-olefin sulfonic acid Salts, especially sodium, magnesium, amines and mono-, di- and triethanolamine salts. Alkyl and fluorenyl groups generally contain from 8 to 18 carbon atoms and may be unsaturated. The alkyl ether sulfonate, alkyl ether phosphate and alkyl ether carboxylate may contain from 1 to 10 ethylene oxide or propylene oxide per molecule. Typical anionic surfactants for use in the shampoos of the present invention comprise sodium succinate, sodium lauryl succinate, ammonium lauryl sulfate, sodium dodecyl benzene sulfonate, triethanolamine lauryl Benzene sulfonate, sodium cocoaisothione, sodium lauryl isothioate and sodium laurate-sodium lauryl. The most preferred anionic surfactants are sodium lauryl sulfate, triethanolamine monolaurate sulphate, sodium lauryl ether sulfate, ruthenium, ruthenium sulphate, ammonium lauryl sulphate and lauryl ether sulphate, 1 ΕΟ and 3 ΕΟ. Examples of amphoteric and zwitterionic surfactants include alkylamine oxides, burnt beet assays, alkylaminopropyl beet assays, sultaines, alkyl acetates, carboxylamine groups. Alkyl acetate, camphor propionate, camphor glyceryl glyceride, guanylpropyl hydroxy thiobetaine, decyl tartrate and decyl gluconate, wherein both alkyl and decyl groups have 8 to 19 carbon atoms. The general amphoteric and zwitterionic surfactants used in the shampoos of the present invention comprise laurylamine oxide, coco-dimethylthiopropyl betaine, and preferably lauryl betaine, cocoa propyl propyl beet. Check for cocoa camphor propionate. The shampoo compositions may also contain a co-surfactant to assist in imparting aesthetic, physical or cleansing properties to the shampoo. A preferred example is a nonionic surfactant -30- This paper scale applies to the Chinese National Standard (CNS) A4 specification (210X297 public 1299268 A7)

’其可包含全部組合物之0至約5重量％之量。 例如，本發明洗髮精組合物中可包含之代表性非離子性 ”面活性劑包含脂系（C8 —C18) 一級或二級直鏈或支鏈醇或 酚與環氧烷，通常為環氧乙烷且一般具有6至3〇個環氧乙 烷基之縮合產物。 其他代表性非離子性包含單_或二-烷基烷醇醯胺。實例 包含可可單·或二-乙醇醯胺及可可單異丙醇醯胺。 本發明洗髮精組合物中可包含之另一種非離子性介面活 性劑為烷基多配糖物（APGs)。通常，APG為包括與一或多 個胺基乙醯基之嵌段相連（視情況經由橋基相連）者。較佳 之APG之定義如下式： RO - (G) η 其中R為飽和或不飽和支鏈或直鏈烷基，且G為糖基。 R可代表平均烷基鏈長約C5至約C20。較佳之R代表平均 烧基鏈長約C8至約C12。最佳之R在約9.5至約10.5之間。 G可遠自C5或C6早穆殘基’且較好為配糖物。g可選自包 括葡糖、木糖、乳糖、果糖、甘露及其衍生物。較佳之G 為葡糖。 承合度η可為自約1至約1〇或更面之值。較好，η之值在 約1·1至約2之間。最好，η之值在約1.3至約1.5之間。 本發明中所用適當之烷基多配糖物為市售，且包含例如 定義如下之材料：Oramix NS10TM例如SeppicTM; Plantaren 1200TM及 Plantaren 2000TM例如 Henkel。 本發明之洗髮精組合物中界面活性劑（包含任一共界面 -31 - 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐) 1299268 五、發明説明（29 至;o;11:/或礼化劑)之總量一般為全部洗髮精組合物之ο·1 重^，較好為5至重量％，更好為1()至25重量％。 陽離子"L積之聚合物為本發明洗髮精組合物中較佳之成 2以提昇洗髮精之㈣性。“沉積聚合物，，意指在使用過 二，可提升洗髮精組合物中之矽酮成分沈積在預定位置 ，亦即頭髮及/或頭皮屑上之劑類。 =積=σ物可為均聚物或由二或多類單體形成。聚合物 之分子量一般在5,〇〇〇至10,0〇Μ〇〇之間，通常至少為 1〇5〇〇〇^ ^^^ 100,000^^ 2,000,000^ fa1 〇 含陽離子氮之基，如季胺或質子胺基，或其混合物。 3陽離子氮之基一般會以取代基存在沉積聚合物之全部 單體單元部分之上。因此當聚合物非為均聚物時，盆可含 阻隔劑非陽離子單體單元。該聚合物敘述於CTFA保養成 分字典，第三版中。銀離子對非陽離子單體單元之比係經 選擇，使聚合物之陽離子電荷密度在所需範圍中。 適當之陽離子沉積聚合物包含例如具有陽離子胺或季銨 官能性之乙烯基單體與水溶性隔離劑單體如（甲基）丙烯醯 胺、烧基或二烷基（甲基）丙烯醯胺、烷基（甲基）丙烯酸酯 、乙烯基己内酯及乙烯基吡咯啶。烷基及二烷基取代之單 體較好具有C1-C7烷基，更好為^」烷基。其他適用之方 格劑包含乙細基S旨 '乙婦基醉、馬來酸野、丙二醇及乙二 醇。 陽離子胺可為一級、二級或三級胺，依特殊之種類及組 合物之PH而定。通常二級及三級胺，尤其是三級胺為較 -32- 本紙張尺度適用中國國家標準(CNS) A4規格(210x 297公釐) 1299268 A7 _ B7 五、發明説明（30 ) 佳。 胺取代之乙烯基單體及胺可以以胺形式聚合，接著藉由 四級化轉化成銨。 陽離子沉積聚合物可包括由胺-及/或四級錄-取代之單體 及/或可相容之分隔劑單體衍生之單體單元之混合物。 適用之陽離子沉積聚合物包含例如： -1-乙烯基-2-吡啶及1-乙烯基-3-甲基咪唑鹽（例如氣化 物鹽）之共聚物，工業中Cosmetic，Toiletry，及Fragrance Association，（CTFA)稱之為 Polyquaternium-16。該物質係 購自 BASF Wyandotte Corp· (Parsippany，NJ，USA)之商標 LUVIQUAT (例如 LUVIQUAT FC 370)。 -1-乙烯基-2-吡咯啶與二甲基胺基乙基甲基丙烯酸酯之 共聚物，工業（CTFA)中稱之為Polyquaternium-11。該物質 係購自 Gaf Corporation (Wayne，NJ，USA)之商標 GAFQUAT (例如 GAFQUAT 755N); -含陽離子二烯丙基季銨之聚合物，包含例如丙烯醯胺 與二甲基二烯丙基銨氣化物之二甲基二烯丙基銨氣化物均 聚物及共聚物，在工業（CTFA)中分別稱之為Polyquaternium 6 及 Polyquaternium 7 ; -具有3至5個碳原子之不飽和羧酸之均-及共-聚物之胺 基-烷基酯無機酸鹽（如美國專利第4,009,256中所述）； -陽離子聚丙烯醯胺（如W095/2231 1中所述）。 可用之其他陽離子沉積聚合物包含陽離子多糠聚合物， 如陽離子纖維素衍生物、陽離子澱粉衍生物及陽離子瓜耳 -33- 本纸張尺度適用中國國袁槺準(CNS) A4規格(210X 297公釐） 1299268 A7 B7 五、發明説明（31 ) 膠衍生物。 適用於本發明組合物之陽離子多糖聚合物包含下式者： A-0-[R-N + (Rl)(R2)(R3)X-]， 其中：A為無水葡糖殘基，如澱粉或纖維素無水葡糖殘留 物。R為伸烧基、氧基伸烧基、聚氧基伸烧基、或經基伸 烷基、或其結合物。Rl、R2及R3獨立的代表烷基、芳基 、烷芳基、芳烷基、烷氧基烷基或烷氧基芳基，各基均含 達約1 8個碳原子。各陽離子部位之碳原子總數（亦即R1、 R2及R3之碳原子總數）較好約20或更低，且X為陰極子平 衡離子。 陽離子纖維素係購自 Amerchol Corp. (Edison，NJ，USA) 之Polymer JR (商標）及LR (商標）系列聚合物，為經基乙基 纖維素與三甲基胺取代之環氧化物反應之鹽，且在工業 (CTFA)中稱之為Polyquaternium 10。另一類陽離子纖維素 包含羥基乙基纖維素與月桂基二甲基胺取代之環氧化物反 應之聚合物季錄鹽，在工業（CTFA)中稱之為Polyquaternium 24 。此等物質係購自 Amerchol Corp. (Edison，NJ，USA)之 Polymer LM-200 (商標）。 其他適用之陽離子多糖聚合物包含含四級氮之纖維素醚 (例如美國專利第3,962,418號中所述），及醚化纖維素與澱 粉之共聚物（例如美國專利第3,958,58 1號中所述）。 特別適用之陽離子多糖聚合物類為陽離子瓜耳膠衍生物 ，如瓜耳膠經基丙基三鑌氯化物（購自Rhodia (Rhone-Poulenc)，、JAGUAR商標系列）。 -34- 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐）'It may comprise from 0 to about 5% by weight of the total composition. For example, representative nonionic surfactants which may be included in the shampoo compositions of the present invention comprise a lipid (C8-C18) primary or secondary linear or branched alcohol or a phenol and alkylene oxide, usually a ring Ethylene oxide and generally has a condensation product of 6 to 3 oxirane groups. Other representative nonionics include mono- or di-alkyl alkanolamines. Examples include cocoa mono- or di-ethanol decylamine And cocoa monoisopropanol amide. Another nonionic surfactant which may be included in the shampoo compositions of the present invention is alkyl polyglycosides (APGs). Typically, APG is included with one or more amines. The block of the thiol group is attached (optionally via a bridging group). The preferred APG is defined as follows: RO - (G) η where R is a saturated or unsaturated branched or linear alkyl group, and G is The glycosyl group may represent an average alkyl chain length of from about C5 to about C20. Preferably, R represents an average alkyl chain length of from about C8 to about C12. Most preferably R is between about 9.5 and about 10.5. G may be from C5. Or a C6 early residue 'and preferably a glycoside. The g may be selected from the group consisting of glucose, xylose, lactose, fructose, nectar and derivatives thereof. G is glucose. The degree of support η can be from about 1 to about 1 Torr or more. Preferably, the value of η is between about 1.1 and about 2. Preferably, the value of η is between about 1.3 and Approx. 1.5. Suitable alkyl polyglycosides for use in the present invention are commercially available and comprise, for example, materials defined as: Oramix NS10TM such as SeppicTM; Plantaren 1200TM and Plantaren 2000TM such as Henkel. Shampoo compositions of the present invention Medium surfactant (including any common interface -31 - This paper scale applies to Chinese National Standard (CNS) A4 specification (210X297 mm) 1299268 V. Total description of invention (29 to; o; 11: / or ritual agent) The amount is generally ο·1 of the total shampoo composition, preferably 5 to wt%, more preferably 1 () to 25% by weight. The cation "L product of the polymer is the shampoo combination of the present invention. Preferably, it is 2 to enhance the (four) nature of the shampoo. "Deposited polymer, meaning that after use, can enhance the deposition of the ketone component in the shampoo composition at a predetermined position, that is, hair and / Or a dandruff agent. = product = σ can be a homopolymer or formed from two or more types of monomers. The amount is generally between 5 and 10 to 10,0〇Μ〇〇, usually at least 1〇5〇〇〇^ ^^^ 100,000^^ 2,000,000^ fa1 阳离子 contains a cationic nitrogen group, such as a quaternary amine or proton An amine group, or a mixture thereof. 3 The base of the cationic nitrogen is generally present as a substituent on the entire monomer unit portion of the deposited polymer. Therefore, when the polymer is not a homopolymer, the pot may contain a barrier agent non-cationic monomer. The polymer is described in the CTFA Maintenance Ingredient Dictionary, Third Edition. The ratio of silver ions to non-cationic monomer units is selected such that the cationic charge density of the polymer is within the desired range. Suitable cationic deposition polymers include, for example, vinyl monomers having cationic amine or quaternary ammonium functionality with water soluble release agent monomers such as (meth) acrylamide, alkyl or dialkyl (meth) acrylamide , alkyl (meth) acrylate, vinyl caprolactone and vinyl pyrrolidine. The alkyl group and the dialkyl substituted monomer preferably have a C1-C7 alkyl group, more preferably an alkyl group. Other suitable formulas include B-based S's detoxification, maleic acid, propylene glycol and ethylene glycol. The cationic amine can be a primary, secondary or tertiary amine, depending on the particular species and the pH of the composition. Usually the secondary and tertiary amines, especially the tertiary amines, are better than the -32- paper scale. The Chinese National Standard (CNS) A4 specification (210x 297 mm) 1299268 A7 _ B7 5. Inventive Note (30). The amine-substituted vinyl monomer and amine can be polymerized in the form of an amine followed by conversion to ammonium by quaternization. The cationic deposition polymer can comprise a mixture of monomer units derived from amine- and/or tetra-substituted monomers and/or compatible spacer monomers. Suitable cationic deposition polymers include, for example, copolymers of 1-vinyl-2-pyridine and 1-vinyl-3-methylimidazolium salts (e.g., vapor salts), Industrial Cosmetic, Toiletry, and Fragrance Association, (CTFA) is called Polyquaternium-16. This material is commercially available from BASF Wyandotte Corp. (Parsippany, NJ, USA) under the trademark LUVIQUAT (e.g., LUVIQUAT FC 370). A copolymer of 1-vinyl-2-pyrrolidine and dimethylaminoethyl methacrylate, known in the Industrial (CTFA) as Polyquaternium-11. This material is commercially available from Gaf Corporation (Wayne, NJ, USA) under the trademark GAFQUAT (eg, GAFQUAT 755N); - a cationic diallyl quaternary ammonium containing polymer comprising, for example, acrylamide and dimethyl diallyl ammonium Vaporized dimethyl diallyl ammonium vapor homopolymers and copolymers, referred to as Polyquaternium 6 and Polyquaternium 7 in the industrial (CTFA); - unsaturated carboxylic acids having 3 to 5 carbon atoms Amino-alkyl ester mineral acid salts of homo- and co-polymers (as described in U.S. Patent No. 4,009,256); - cationic polypropylene decylamine (as described in W095/2231 1). Other cationic deposition polymers that may be used include cationic polyterpene polymers, such as cationic cellulose derivatives, cationic starch derivatives, and cationic guar-33- This paper scale applies to China National Standards (CNS) A4 specification (210X 297 mm) 1299268 A7 B7 V. INSTRUCTIONS (31) Gum derivatives. A cationic polysaccharide polymer suitable for use in the compositions of the present invention comprises the formula: A-0-[RN + (Rl)(R2)(R3)X-], wherein: A is an anhydrous glucose residue such as starch or fiber. Anhydrous glucose residue. R is a stretching group, an oxyalkylene group, a polyoxyalkylene group, or a transalkyl group, or a combination thereof. Rl, R2 and R3 independently represent an alkyl group, an aryl group, an alkylaryl group, an aralkyl group, an alkoxyalkyl group or an alkoxyaryl group each having up to about 18 carbon atoms. The total number of carbon atoms in each cationic moiety (i.e., the total number of carbon atoms of R1, R2, and R3) is preferably about 20 or less, and X is a cation-balanced ion. The cationic cellulose is commercially available from Amerchol Corp. (Edison, NJ, USA) as Polymer JR (trademark) and LR (Trade Mark) series of polymers, which are reacted with a base ethyl cellulose and a trimethylamine substituted epoxide. Salt, and is called Polyquaternium 10 in the industry (CTFA). Another type of cationic cellulose comprises a polymer quaternary salt of hydroxyethyl cellulose and a lauryl dimethylamine substituted epoxide, which is referred to as Polyquaternium 24 in the industry (CTFA). These materials were purchased from Polymer LM-200 (trademark) of Amerchol Corp. (Edison, NJ, USA). Other suitable cationic polysaccharide polymers include cellulose salts containing a quaternary nitrogen (e.g., as described in U.S. Patent No. 3,962,418), and copolymers of etherified cellulose and starch (e.g., U.S. Patent No. 3,958,58 1 Said). Particularly suitable cationic polysaccharide polymers are cationic guar derivatives such as guar via propyl trihydrazide chloride (available from Rhodia (Rhone-Poulenc), JAGUAR trademark series). -34- This paper size applies to Chinese National Standard (CNS) A4 specification (210 X 297 mm)

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1299268 A7 B7 五、發明説明（32 ) 實例為JAGUAR C13S，其具有低度陽離子基取代及高 黏度。JAGUAR C15具有中度陽離子基取代及低黏度， JAGUAR C17 (高度取代，高黏度），JAGUAR C 16為低度 取代基之羥基丙基化陽離子瓜耳膠衍生物以及陽離子季銨 取代基，且JAGUAR 162為具有低度取代之高透明性中黏 度瓜耳膠。 較好陽離子沉積聚合物係選自陽離子纖維素及陽離子瓜 耳膠衍生物。最佳之沉積聚合物為JAGUAR C13S，1299268 A7 B7 V. INSTRUCTIONS (32) An example is JAGUAR C13S, which has a low degree of cationic substitution and high viscosity. JAGUAR C15 has a moderate cationic substitution and low viscosity, JAGUAR C17 (highly substituted, high viscosity), JAGUAR C 16 is a low-substituted hydroxypropylated cationic guar derivative and a cationic quaternary ammonium substituent, and JAGUAR 162 is a high-viscosity medium-viscosity guar gum with low substitution. Preferably, the cationic deposition polymer is selected from the group consisting of cationic cellulose and cationic guar derivatives. The best deposition polymer is JAGUAR C13S,

JAGUAR C15，JAGUAR C17 及 JAGUAR C16 及 JAGUAR C162 〇 陽離子沉積聚合物之含量一般為全部組合物之〇 . 〇 〇 1至 5%，較好為〇.〇1至1%，更好違約0.02至約0.5重量％。 潤濕精 本發明之組合物亦可調配成頭髮處理（一般係在洗頭後） 及後續潤濕用之潤濕精。 該潤濕精包括一種或多種潤濕界面活性劑，其為保養上 可接受且適用於頭髮之局部使用。 適當之潤濕界面活性劑係選自陽離子界面活性劑，單獨 或以預混合物使用。實例包含季胺氫氧化物或其鹽，例如 氯化物。 本發明頭髮潤濕劑中所用之適當陽離子界面活性劑包含 十四烷基三甲基胺氣化物、二十二烷基三曱基胺氣化物、 十四烷基吡啶氯化物、四甲基胺氣化物、四乙基胺氯化物 、辛基三▼基胺氣化物、十二烷基三f基胺氣化物、十六 -35- 本紙張尺度適用中B B家料(CNS) A4規格(21GX 297公釐) 1299268 A7 B7 烷基二甲基胺氣化物、辛基二甲基节基胺氯化物、癸基二 甲基芊基胺氣化物、硬脂基二甲基苄基胺氣化物、二碘癸 基二甲基胺氯化物、二十八烷基二甲基胺氣化物、牛油三 甲基胺氣化物、可可三甲基胺氣化物、及其相對應之氫氧 化物。其他適用之陽離子界面活性劑包含CTFa命名之The content of JAGUAR C15, JAGUAR C17 and JAGUAR C16 and JAGUAR C162 cation-deposited polymer is generally 全部. 〇〇1 to 5%, preferably 〇.〇1 to 1%, more preferably 0.02 to about 0.02. 0.5% by weight. Wetting essence The compositions of the present invention may also be formulated into hair treatments (generally after shampooing) and wetting concentrates for subsequent wetting. The moisturizer comprises one or more wetting surfactants which are maintenance acceptable and suitable for topical application to the hair. Suitable wetting surfactants are selected from cationic surfactants, either alone or in a premix. Examples include quaternary ammonium hydroxides or salts thereof, such as chlorides. Suitable cationic surfactants for use in the hair wetting agent of the present invention comprise tetradecyl trimethylamine vapor, behenyl tridecylamine vapor, tetradecylpyridinium chloride, tetramethylamine Vapor, tetraethylamine chloride, octyltrioxylamine vapor, dodecyltrifylamine vapor, hexa-35- paper grade suitable for BB home stock (CNS) A4 specification (21GX 297 mm) 1299268 A7 B7 alkyl dimethylamine vapor, octyl dimethyl benzyl amine chloride, mercapto dimethyl decyl amine vapor, stearyl dimethyl benzyl amine vapor, Diiododecyldimethylamine chloride, octadecyldimethylamine vapor, tallow trimethylamine vapor, cocotrimethylamine vapor, and its corresponding hydroxide. Other suitable cationic surfactants include CTFa nomenclature

Quaternium-5 ’ Quaternium-31 及 Quaternium-18之物質。任 一刖述物質之混合物亦適用。本發明頭髮潤濕精特別適用 之陽離子界面活性劑為十四烷基三甲基胺氯化物、購自例 如 GENAMIN CTACTM，例如 Hoechst Celanese。 本毛明之潤濕精中，陽離子界面活性劑之量較好為組合 物之0.01至10%，更好為〇 05至5%。最好為〇」至2重量％。 本發明之潤濕精較好添加脂肪醇。合併使用脂肪醇及陽 離子界面活性劑相信特別有利，因為此將導致形成層狀相 ，且％離子界面活性劑分散於其中。 月曰肪％之代表例包括8至22個碳原子，更好16至個碳 原子。適用脂肪醇之實例包含十四烷基醇、硬脂基醇、及 其混合物。使用此等材料對於賦予本發明組合物之整體潤 濕性亦有利。 本I月組合物中之脂肪醇含量一般為組合物之〇 〇 1至 10%旦較好為ο.Λ至5重量％。陽離子界面活性劑對脂肪醇 之重里比為10:u1:10，較好為4:1至18，且最好 1:4 〇 造型# t 月之頭髮處理組合物亦包含造型髮膠之形式。 裝 訂Substances of Quaternium-5' Quaternium-31 and Quaternium-18. Mixtures of any of the substances described are also applicable. A particularly useful cationic surfactant for the hair moisturizing agent of the present invention is tetradecyl trimethylamine chloride, available from, for example, GENAMIN CTACTM, such as Hoechst Celanese. In the moistening essence of the present invention, the amount of the cationic surfactant is preferably from 0.01 to 10%, more preferably from 5% to 5%, of the composition. It is preferably 〇" to 2% by weight. The moisturizing agent of the present invention preferably adds a fatty alcohol. The combined use of fatty alcohols and cationic surfactants is believed to be particularly advantageous as this will result in the formation of a lamellar phase in which the % ionic surfactant is dispersed. Representative examples of the monthly fat percentage include 8 to 22 carbon atoms, more preferably 16 to carbon atoms. Examples of suitable fatty alcohols include myristyl alcohol, stearyl alcohol, and mixtures thereof. The use of such materials is also advantageous for imparting the overall wetting of the compositions of the present invention. The fatty alcohol content of the composition of the present month is generally from 〇 至 to 5% by weight of the composition. The weight ratio of the cationic surfactant to the fatty alcohol is 10:u1:10, preferably 4:1 to 18, and preferably 1:4 〇. The hair treatment composition of the month is also in the form of a styling hair gel. Binding

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1299268 A7 _ B7 五、發明説明（34 ) 該造变髮膠將包括水溶性成膜樹脂。該樹脂可為陰離子 性、非離子性、兩性或陽離子。特殊樹脂包含聚乙烯基吡 咯啶酮、（PVP)與甲基丙烯酸甲酯之共聚物，PVP與乙酸 乙烯酯（VA)之共聚物，聚乙烯基醇（PVA)、PVA與巴豆酸 之共聚物、PVA與馬來酸酐之共聚物、羥基丙基纖維素、 羥基丙基瓜耳膠、聚苯乙晞磺酸鈉、PVP/乙基丙烯酸乙醋 /甲基丙烯酸三聚物、乙酸乙烯酯/巴豆酸/辛癸酸乙烯酯共 聚物、辛基丙烯醯胺/丙烯酸酯共聚物、聚甲基乙烯基醚/ 馬來酸之單乙基酯、及辛基丙烯醯胺/丙烯酸酯/ 丁基胺乙 基甲基丙烯酸酯共聚物。亦可使用樹脂之混合物。較好為 PVP及與其他單體之PVP共聚物，例如聚乙烯基吡咯啶酮 及乙酸乙烯酯之共聚物，尤其是70/30比。 成膜樹脂之量可為0.1至20%，較好為1至10%，且最好 為2至5重量％。 本發明之造型髮·膠中可含小量介面活性劑，其量為〇. i 至約1 0%，較好自約〇· 1至1 %，且最好約〇·3重量％。介面 /舌性劑可為陰離子性、非離子性或陽離子性乳化劑。最佳 者為非離子性乳化劑，其係由親脂如脂肪醇、脂肪酸及酚 之烷氧基化形成。 本發明之頭髮處理組合物可含任一種頭髮處理組合物中 常用之其他成分。其他成分可包含黏度改質劑、防腐劑、 著色劑、多元醇如甘油及聚丙二醇、螯合劑如EDTA、抗 氧化劑、殺菌劑及陽光吸收劑。各此等成分均含有效量已 達成該目的。一般此等選用之成分均以達總組合物量之約 -37- 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐）1299268 A7 _ B7 V. INSTRUCTIONS (34) The hair gel will comprise a water-soluble film-forming resin. The resin may be anionic, nonionic, amphoteric or cationic. The special resin comprises polyvinylpyrrolidone, a copolymer of (PVP) and methyl methacrylate, a copolymer of PVP and vinyl acetate (VA), a polyvinyl alcohol (PVA), a copolymer of PVA and crotonic acid. , copolymer of PVA and maleic anhydride, hydroxypropyl cellulose, hydroxypropyl guar, sodium polystyrene sulfonate, PVP/ethyl acrylate/methacrylic acid terpolymer, vinyl acetate/ Crotonic acid/vinyl octanoate copolymer, octyl acrylamide/acrylate copolymer, polymethyl vinyl ether/monoethyl maleate, and octyl acrylamide/acrylate/butyl Amine ethyl methacrylate copolymer. A mixture of resins can also be used. PVP and PVP copolymers with other monomers, such as copolymers of polyvinylpyrrolidone and vinyl acetate, are preferred, especially 70/30 ratio. The amount of the film-forming resin may be from 0.1 to 20%, preferably from 1 to 10%, and more preferably from 2 to 5% by weight. The styling gel of the present invention may contain a small amount of an surfactant, in an amount of from 0.1 to about 10%, preferably from about 1 to about 1%, and most preferably from about 3% by weight. The interface/tongue agent can be an anionic, nonionic or cationic emulsifier. Most preferred are nonionic emulsifiers which are formed by alkoxylation of lipophilic such as fatty alcohols, fatty acids and phenols. The hair treatment compositions of the present invention may comprise any of the other ingredients commonly used in any hair treatment composition. Other ingredients may include viscosity modifiers, preservatives, colorants, polyols such as glycerin and polypropylene glycol, chelating agents such as EDTA, antioxidants, bactericides, and sun absorbents. Each of these ingredients contains an effective amount to achieve this purpose. Generally, these selected ingredients are about ～37- The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm).

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線 1299268Line 1299268

發明説明 5重量％存在。 較好’本發明之組合物亦含適用於頭髮保養之佐劑。一 般4成分係以達總組合物2 % ,較好達1重量％之量單獨存 在。 適用之頭髮保養佐劑為： (1)天然髮根滋養物，如胺基酸及糖。該胺基酸包含精胺 酸、S藍基丙胺酸、穀胺醯胺、胺基戊二酸、異白胺酸、白 胺酸、蛋胺酸、絲胺酸及擷草胺酸，及/或前驅物及其衍 生物。胺基酸可以單獨、以混合物或以肽，例如二或三肽 之形式添加。胺基酸亦可以以蛋白質水解物之形式添加， 例如角質或膠原水解物。適用之糖為葡萄糖、右旋糖及果 糖。此等可以單獨添加或以水果萃取液之方式添加。本發 明組合物中包含之天然髮根滋養物中最佳之結合物為異白 私:酸及葡萄糖。最佳之胺基酸滋養物為精胺酸。 (ii)對頭髮纖維有益之劑類。實例為神經醯胺，使纖維 濕潤且維持表面整體性。神經醯胺係使用天然萃取液，及 合成神經醯胺與擬神經醯胺。較佳之神經酿胺為神經酿胺 Π，例如Quest。神經醯胺之混合物亦適用，如神經醯胺 LS ’ 例如 Laboratoires Serobiologiques。 本發明將以下列非限制用實例進一步說明： 實例 貫例中’所有百分比均為重量，除非另有說明。Description of the invention 5 wt% is present. Preferably, the compositions of the present invention also contain an adjuvant suitable for hair care. The general four components are present in an amount of up to 2% by weight of the total composition, preferably up to 1% by weight. Applicable hair care adjuvants are: (1) Natural hair root nourishments such as amino acids and sugars. The amino acid comprises arginine, S-blue alanine, glutamine, amino glutaric acid, isoleucine, leucine, methionine, serine and humic acid, and/ Or precursors and their derivatives. The amino acid may be added singly, in a mixture or in the form of a peptide such as a di- or tripeptide. The amino acid can also be added in the form of a protein hydrolysate, such as a keratin or collagen hydrolysate. Suitable sugars are glucose, dextrose and fructose. These may be added separately or as a fruit extract. The best combination of natural hair root nourishments contained in the compositions of the present invention is iso-white: acid and glucose. The best amino acid nourishment is arginine. (ii) Agents that are beneficial to hair fibers. An example is neuroketamine, which wets the fibers and maintains surface integrity. The neural amines use natural extracts and synthesizes neuropterin and pseudo-neuramin. A preferred neurofunctional amine is a neuromannamine such as Quest. Mixtures of ceramides are also suitable, such as the neuropterin LS' such as Laboratoires Serobiologiques. The invention will be further illustrated by the following non-limiting examples: EXAMPLES In the examples, all percentages are by weight unless otherwise indicated.

Zinc Omadine係購自 〇Πη Jaguar沉積聚合物係購自Rhodia -38- 本紙張尺度適财S S家標準(CNS) A4規格(2ι〇χ297公董) 1299268 A7 厂 ___ B7 _____ 五、發明説明（36 )Zinc Omadine is purchased from 〇Πη Jaguar deposited polymer series from Rhodia -38- This paper scales the appropriate size of the SS standard (CNS) A4 specifications (2 〇χ 297 dongdong) 1299268 A7 Factory ___ B7 _____ V. Description of invention ( 36)

Silicone 油及乳液（DC2-1391 TM及 DC2-1699TM)係購自 道康寧。. 實例1 ' 含固態抗菌活性鋅吡啶硫酮（ZnPT〇)之剪切凝膠物質之 製備。 將 Agar (Luxura 1253ΤΜ，Arthur Branwell，0.5%)分散 在冷水中，且加熱至95°C，直到完全溶解（直到水為透明） 。接著添加2^11(：〇11^(1丨1^(含：2%活性鋅17比咬硫酮）且混合於 其中。將混合物導入前述且於圖1 b中說明之攪拌槽中（在 85 °C下）。接著在1〇〇〇 rpm下混合5分鐘，以確保完全混合 ，接著在500 rpm下冷卻至5°C約30分鐘（約2.50C/分鐘）。 相對比顯微鏡呈相證明鋅ΪΙ比唆硫酮實質上均存在於瓊脂剪 切凝膠顆粒中，且在該例中維持至少4個月。 圖3係顯示包封在剪切瓊脂凝膠顆粒中之鋅吡啶硫酮之 相對比光顯微鏡相片。注意：照片寬度為13〇微米。 實例2 以下提供一種含鋅吡啶硫酮及瓊脂剪切凝膠顆粒之洗髮 精調配物。 成分之實際添加量如下所列，括號中為其活性水準。 -39- 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 1299268 A7 B7 五、發明説明（37 ) 成分 實例1 具有0 j%Luxara 1253 瓊脂(％w/w) 之洗髮精 實例2 具有3.0% Quest LTS 環脂(％ w/w) 之洗髮精 實例3 具有0.5% Quest LTS環脂(％ w/w) 之洗髮精 月桂酸鈉 2-乙氧基硫酸酯 (70%活性)初級界 面活性劑 20 (14) 20 (14) 20(14) 可可-醯胺基丙基 甜菜鹼(30%活性) 輔界面活性劑 6.67 (2) 6.67 (2) 6.67 (2) Jaguar C13S (1% 水溶液)調理劑， 沉積助劑 10(0.1) 10(0.1) 10(0.1) ZnPTO (48%水溶 液)活性 1.048 (0.5) 1.048 (0.5) 1.048 (0.5) DMDM Hydantion (100%活性液體） 防腐劑 0.3 (0.3) 0.3 (0.3) 0.3 (0.3) CI 42051藍色染料 (0.0144%水溶液） 染料 2.5 (0.0036) 2.5 (0.0036) 2.5 (0.0036) 瓊脂剪切凝膠(0.5 或3.0%水準之水 溶液)懸浮系統 50 (0.5% Luxara 1253) 50 (3.0% Quest Deltagar LTS) 50 (0.5% Quest Deltagar LTS) NaCl (固體100%) 黏度調整劑 To spec To spec To spec NaOH/檸檬酸 pH調整劑 To spec To spec To spec 水溶劑 至 100% 至 100% 至 100% 說明 使用NaOH/檸檬酸將pH調整為5.5-6.5。添加NaCl (通常 -40 - 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 1299268 A7 __ B7 五、發明説明（38 ) 為1至1.5%)將黏度調整為4500至5500。 針對貫例3之比較試驗’使用與鋅吡啶硫酮包封在瓊脂 剪切凝膠顆粒中，及不含剪切瓊脂凝膠顆粒下之調配物。 調配物均相同，但製造不同。後一情況下，係先製備瓊脂 剪切凝膠’接著配合其他洗髮精成分，將鋅吡啶硫酮於洗 髮精製備過程中添加於剪切凝膠基底中。前一例中，係使 外匕唆硫嗣與瓊脂溶膠共處理，知實例1中詳述。其他洗髮 精成分接著於洗髮精製造過程中，添加於充填之剪切凝膠 基底中。 實例3 沉積試驗 協定 以0.27亳升自來水（室溫）稀釋之〇·〇3克產物調配物洗務2 英吋（50.8 毫米）/〇·25 克開關（virgin，proximal Chinese 髮） 30秒。開關接著以升溫之循環自來水（c a· 35°c )洗務30秒 。洗滌/潤濕相接著重複五次，且對各處理製備。 假髮架設在塑膠環之上，使得最大量之頭髮露在環之中 心，接著以光譜儀純之6微米聚丙烯膜覆蓋，以避免頭髮 流失。裝置之假髮接著使用X-射線螢光，對頭髮表面上之 元素鋅進行分析。該技術中，X-射線束撞擊頭髮表面，電 子以原子之低能量水準撞擊頭髮表面，較高能階之電子降 下來以取代此等發射之電子。該製程係藉由第二射線態 之電磁輻射發射（因此定義為螢光）達成。該發射輻射之強 度及絕對能量提供在頭髮表面及之中之原子能階之指標及 I____-41 - 本纸張尺度適财® ®家標準(CNS) Α4規格(21G X 297公釐) "" " --- 1299268 A7 B7 五、發明説明（39 ) 特性。 · 需假設頭髮後洗滌上偵測之較高量鋅相當於沉積在頭髮 上之ZnPTO。假髮可以以不同量之ZnPTO投藥，且測量頭 髮表面上之最終鋅量，因此可調整沉積在頭髮上之ZnPTO 量（ppm) 〇 試驗產物之效能 圖4說明實例2之三試驗調配物之ZnPTO沉積量，本發明 ，及比較ZnPTO並未包封在剪切凝膠顆粒中之相對應調配 物。 意外的，具有包封在剪切凝膠凝膠顆粒中之ZnPTO顆粒 之本發明組合物之ZnPTO沉積優於另一相同組合物中不含 ZnPTO之組合物沉積（亦即，未包封在凝膠顆粒中）。 實例4潤濕洗#精 含剪切凝膠物質之矽酮油，DC2-1391TM (粒徑40-50奈 米）之製備。 將瓊脂（Quest DeltagarTM，0.5%)分散在冷水中，且加 熱至95 °C，直到完全溶化（直到澄清）。溶液接著冷卻至 60°C，再添加矽酮油（DC2-1391TM，2%全部乳液，0.5% 活性）。將該油及瓊脂溶膠混合在一起，接著注入前述且 說明於圖lb中之授拌槽（在60 °C下）中。接著在1000 rpm下 混合5分鐘，以確保完全混合，接著在500 rpm下冷卻至5°C 約20分鐘（約3°C /分鐘）。傳輸電子顯微鏡照片證明矽酮油 液滴與瓊脂剪切凝膠顆粒中之瓊脂鏈結合。 圖5為在傳輸電子顯微鏡下之剪切瓊脂凝膠顆粒之低放 -42 - 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐）Silicone oils and emulsions (DC2-1391 TM and DC2-1699TM) were purchased from Dow Corning. Example 1 'Preparation of a shear gel material containing solid antimicrobial activity zinc pyrithione (ZnPT®). Agar (Luxura 1253®, Arthur Branwell, 0.5%) was dispersed in cold water and heated to 95 ° C until completely dissolved (until the water was clear). Then add 2^11(:〇11^(1丨1^(containing: 2% active zinc 17 to bite thione)) and mix it in. Introduce the mixture into the agitating tank described above and illustrated in Figure 1 b (in Mix at 85 ° C. Then mix for 5 minutes at 1 rpm to ensure complete mixing, then cool to 5 ° C for about 30 minutes (about 2.50 C / min) at 500 rpm. Zinc oxime is substantially present in the agar shear gel particles and is maintained in this example for at least 4 months. Figure 3 shows the zinc pyrithione encapsulated in shear agar gel particles. Relative light microscope photo. Note: The photo width is 13 μm. Example 2 The following is a shampoo formulation containing zinc pyrithione and agar shear gel particles. The actual addition amount of the ingredients is as follows, in brackets For its activity level. -39- The paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) 1299268 A7 B7 V. Description of invention (37) Composition example 1 with 0 j% Luxara 1253 agar (%w /w) Shampoo Example 2 Shampoo Example 3 with 3.0% Quest LTS Ring Grease (% w/w) Shampoo sodium laurate 2-ethoxysulfate (70% active) primary surfactant with 0.5% Quest LTS cyclolip (% w/w) 20 (14) 20 (14) 20(14) Cocoa - Amidinopropyl betaine (30% active) Cosurfactant 6.67 (2) 6.67 (2) 6.67 (2) Jaguar C13S (1% aqueous solution) conditioner, deposition aid 10(0.1) 10(0.1) 10 (0.1) ZnPTO (48% aqueous solution) activity 1.048 (0.5) 1.048 (0.5) 1.048 (0.5) DMDM Hydantion (100% active liquid) Preservative 0.3 (0.3) 0.3 (0.3) 0.3 (0.3) CI 42051 blue dye ( 0.0144% aqueous solution) Dye 2.5 (0.0036) 2.5 (0.0036) 2.5 (0.0036) Agar shear gel (0.5 or 3.0% aqueous solution) suspension system 50 (0.5% Luxara 1253) 50 (3.0% Quest Deltagar LTS) 50 ( 0.5% Quest Deltagar LTS) NaCl (100% solids) Viscosity modifier To spec To spec To spec NaOH/citric acid pH adjuster To spec To spec To spec Water solvent to 100% to 100% to 100% Description Use NaOH/Lemon The acid adjusts the pH to 5.5-6.5. Add NaCl (usually -40 - This paper scale applies to Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1299268 A7 __ B7 V. Invention description (38) is 1 to 1.5%) Adjust the viscosity to 4500 to 5500 . The comparative test for Example 3 used was formulated with a zinc pyrithione encapsulated in agar shear gel particles and without a shear agar gel particle. The formulations are all the same, but the manufacturing is different. In the latter case, an agar shear gel is prepared first, followed by other shampoo ingredients, and the zinc pyrithione is added to the shear gel substrate during the shampoo preparation process. In the former example, the external thiopurine was co-treated with an agar sol, as detailed in Example 1. The other shampoo ingredients are then added to the filled shear gel substrate during the shampoo manufacturing process. Example 3 Deposition Test Protocol Dilution with 0.27 liters of tap water (room temperature) 〇·〇 3 g of product formulation wash 2 吋 (50.8 mm) / 〇 · 25 g switch (virgin, cosmetic Chinese hair) 30 seconds. The switch is then washed with circulating water (c a · 35 ° c) for 30 seconds. The wash/wet phase was then repeated five times and prepared for each treatment. The wig is placed over the plastic ring so that the largest amount of hair is exposed in the center of the ring and then covered with a spectrometer pure 6 micron polypropylene film to avoid hair loss. The wig of the device is then analyzed for zinc on the surface of the hair using X-ray fluorescence. In this technique, the X-ray beam strikes the surface of the hair, and the electrons strike the surface of the hair at a low energy level of the atom, and electrons of higher energy levels are lowered to replace the emitted electrons. The process is achieved by electromagnetic radiation emission (and thus defined as fluorescence) in the second ray state. The intensity and absolute energy of the emitted radiation provide an indication of the atomic energy level on the surface of the hair and I____-41 - This paper scales the Standard® (CNS) Α4 specification (21G X 297 mm) "&quot ; " --- 1299268 A7 B7 V. Description of invention (39) Characteristics. • It is assumed that the higher amount of zinc detected on the post-hair wash is equivalent to the ZnPTO deposited on the hair. The wig can be administered in different amounts of ZnPTO and the final amount of zinc on the surface of the hair is measured, thus adjusting the amount of ZnPTO deposited on the hair (ppm). The efficacy of the test product. Figure 4 illustrates the ZnPTO deposition of the test formulation of Example 3 The amount, the present invention, and the comparison of the ZnPTO are not encapsulated in the corresponding formulation of the shear gel particles. Unexpectedly, the ZnPTO deposition of the composition of the invention having ZnPTO particles encapsulated in shear gel gel particles is superior to the deposition of a composition containing no ZnPTO in another identical composition (i.e., unencapsulated in the coagulation) In the rubber particles). Example 4 Wetting Wash # 精 Preparation of an anthrone oil containing a shear gel material, DC2-1391TM (particle size 40-50 nm). Agar (Quest DeltagarTM, 0.5%) was dispersed in cold water and heated to 95 °C until completely dissolved (until clarification). The solution was then cooled to 60 ° C and then anthrone oil (DC2-1391TM, 2% total emulsion, 0.5% active) was added. The oil and agar sol were mixed together and then injected into the mixing tank (at 60 ° C) as described above and illustrated in Figure lb. It was then mixed at 1000 rpm for 5 minutes to ensure complete mixing, followed by cooling to 5 ° C for about 20 minutes (about 3 ° C / min) at 500 rpm. Transmission electron micrographs demonstrate that the oxime oil droplets bind to the agar chain in the agar shear gel particles. Figure 5 shows the low-resolution of shear agar gel particles under a transmission electron microscope -42 - This paper scale applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm)

裝 訂Binding

1299268 A7 B7 五、發明説明（4〇 ) 大照片。 圖6為顯示剪切瓊脂凝膠顆粒中之DC2-1391TM矽酮油液 滴之高倍數放大照片。 f例5 潤濕洗#精 典型洗髮精調配物如下： % AD為活性之％ % Comp為最終組合物中活性之％ % w/w為添加全部成分之百分比。 成分 %AD % Comp 功能 % w/w Empicol ESB70 70 14 初級界面活性劑 20.0 可可丙基甜菜鹼 30 2 共界面活性劑 6.65 Jaguar C13S 100 0.1 潤濕劑，沉積助劑 0.1 Quest Deltagar LTS + DC-1391 0.5 0.34 活性及懸浮系統 68 Athene 929 100 0.55 香料 0.55 苯曱酸鈉 100 0.5 防腐劑 0.5 Sepicide Ld 100 0.4 防腐劑 0.4 |TimironMP1001 100 0.2 霧化劑 0.2 II氣化鈉 100 0.8 黏度調整劑 0.8 丨水 ―—_ 100 - 溶劑 至100 上述組合物係針對已含包封在其中之矽酮油之0.5%剪切 瓊脂（0.5%活性，全部之2%)。 實例6 可使用許多不同類之瓊脂剪切凝膠以獲得活性。若需要 不同之顆粒流變，則可使用不同之瓊脂類。該實例與實例 1相同，僅所用之填脂為日本Ina食品工業之Ina Ultra Agar (AX-30) 〇 圖6顯示包封在相當不嚴謹定義之剪切凝膠顆粒中之矽 -43- 本紙張尺度適用中國國家標準(CNS) Α4規格(210 X 297公釐） I299268 A7 __B7__ 五、發明説明（41 ) 顚I油乳液，DC2-1669 (道康寧）。若凝膠顆粒並未定義成 較硬之瓊脂凝膠，氮矽酮乳液幾乎與多糖鏈結合，且並未 與基質相違背。 f例7 本實例對瓊脂提供另一多糖。該多糖為K-角叉菜。 將 K-角叉菜（0.5%，Genugel，X909，Hercules)添加於冷 蒸餾水中，且加熱至60°C直到完全溶解。接著添加山梨酸 鉀（0.02%)及氣化鉀（0.22%)且混合。Omadine 鋅（2% (=1〇/〇 活性ZnPTO))或將矽酮乳液（0.5°/。活性DC2-1669，道康寧） 添加於分散液中，且在60°C下將混合物添加於攪拌槽中， 且冷卻至5 °C，如實例1中所述。 顯微照相顯示在K-角叉菜剪切凝膠顆粒中之包封ζηρτ〇 (圖7)及在Κ-角叉菜剪切凝膠顆粒中之包封矽酮乳液（圖8)。 實例8 蛋白質剪切凝膠一含乳漿蛋白質之油之實例。乳漿蛋白 質分離（400克，Bipro Davisco食品）以攪拌分散在冷水中 (3600克’室溫，20°C )，直到所有粉末溶解為止。接著使 該乳漿溶液加熱至80°C，同時緩慢攪拌，維持在8〇°c下30 分鐘且授拌，接著冷卻至室溫。 將葵花油（400克）添加於加熱之乳漿溶液（36〇〇克）中，混 合且通過在300巴下操作之均質機（Crepac〇 A3活塞式均質 機）一次’得到D3,2 = 〇.4微米之乳液分散液（以Malvern之 Mastersizer測量）。 該乳液接著使用微-votat〇]^l (圖9中詳述）製造剪切乳漿 -44 - 本紙張尺度適财SS家標準(CNS) A4規格(2iGX297公釐）----- 1299268 A7 _____B7 _ __ 五、發明説明（42 ) 顆粒。乳聚乳液置於桶A中，且將乳酸溶浪（約1 · 5°/。）置於 桶B中。以泵浦將二溶液注入管線中，自桶進入混合C單 元中（體積12 0宅升之p i η混合機）。混合及駐留時間之比係 以泵浦速度控制。蛋白質溶液係在42.5克/分鐘下泵浦，且 酸係在10克/分鐘下泵浦。桶維持在2(rc，且C單元維持在 40°C，且在1400 rpm下操作。離開單元之溶液溫度為35。〇 。接著使樣品通過在1000 rpm及2(^c下操作之另外三A-單 元，以增加駐留時間。由此等單元離開之溫度為20t。顆 粒之pH為5.2 ’且含6.9%蛋白質及8· ι〇/〇油。 -45- 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐)1299268 A7 B7 V. Description of invention (4〇) Large photo. Figure 6 is a high magnification magnified photograph showing the DC2-1391TM fluorenone oil droplets in the shear agar gel particles. f Example 5 Wetting Wash #精 Typical shampoo formulations are as follows: % AD is % of activity % Comp is % of activity in the final composition % w/w is the percentage of all ingredients added. Ingredient %AD % Comp Function % w/w Empicol ESB70 70 14 Primary surfactant 20.0 Cocopropyl betaine 30 2 Common surfactant 6.65 Jaguar C13S 100 0.1 Wetting agent, deposition aid 0.1 Quest Deltagar LTS + DC-1391 0.5 0.34 Activity and Suspension System 68 Athene 929 100 0.55 Perfume 0.55 Sodium Benzoate 100 0.5 Preservative 0.5 Sepicide Ld 100 0.4 Preservative 0.4 | Timiron MP1001 100 0.2 Atomizer 0.2 II Sodium Carbide 100 0.8 Viscosity Modifier 0.8 Water - - 100 - Solvent to 100 The above composition is directed to 0.5% shear agar (0.5% active, 2% overall) which already contains the ketone oil encapsulated therein. Example 6 A number of different types of agar shear gels can be used to obtain activity. Different agars can be used if different particle rheology is required. This example is the same as in Example 1, except that the fat used is Ina Ultra Agar (AX-30) of the Japanese Ina Food Industry. Figure 6 shows the 矽-43-本 encapsulated in a relatively imprecisely defined shear gel particle. The paper scale applies to the Chinese National Standard (CNS) Α4 specification (210 X 297 mm) I299268 A7 __B7__ V. Description of invention (41) 顚I oil emulsion, DC2-1669 (Dow Corning). If the gel particles are not defined as a hard agar gel, the oxenone emulsion binds almost to the polysaccharide chain and does not interfere with the matrix. f Example 7 This example provides another polysaccharide to agar. The polysaccharide is K-carrageen. K-carrageen (0.5%, Genugel, X909, Hercules) was added to cold distilled water and heated to 60 ° C until completely dissolved. Next, potassium sorbate (0.02%) and potassium carbonate (0.22%) were added and mixed. Omadine zinc (2% (=1 〇 / 〇 active ZnPTO)) or an anthrone emulsion (0.5 ° / active DC2-1669, Dow Corning) was added to the dispersion, and the mixture was added to the stirred tank at 60 ° C Medium and cooled to 5 °C as described in Example 1. The photomicrograph shows the encapsulated ζρτ〇 (Fig. 7) in the K-carrageenan shear gel granules and the encapsulated fluorenone emulsion in the Κ-carrageenan shear gel granules (Fig. 8). Example 8 Protein Shear Gel An example of a milk protein containing oil. The serum protein fraction (400 g, Bipro Davisco food) was dispersed in cold water (3600 g 'room temperature, 20 ° C) with stirring until all the powder was dissolved. The slurry solution was then heated to 80 ° C while stirring slowly, maintained at 8 ° C for 30 minutes and allowed to mix, followed by cooling to room temperature. Sunflower oil (400 g) was added to the heated slurry solution (36 g), mixed and passed through a homogenizer (Crepac® A3 piston homogenizer) operating at 300 bar to obtain D3, 2 = 〇 .4 micron emulsion dispersion (measured by Malvern's Mastersizer). The emulsion is then made using micro-votat〇^^l (detailed in Figure 9) to make a sheared serum-44 - This paper scale is suitable for the SS standard (CNS) A4 specification (2iGX297 mm)----- 1299268 A7 _____B7 _ __ V. Description of invention (42) Particles. The emulsion emulsion was placed in the barrel A, and the lactic acid solution (about 1.25 °/.) was placed in the barrel B. The two solutions are pumped into the pipeline and pumped from the tank into the mixing C unit (volume 12 liters of p i η mixer). The mixing and dwell time ratio is controlled by pump speed. The protein solution was pumped at 42.5 g/min and the acid system was pumped at 10 g/min. The barrel was maintained at 2 (rc, and the C unit was maintained at 40 ° C and operated at 1400 rpm. The temperature of the solution leaving the unit was 35. 接着. Then the sample was passed through the other three at 1000 rpm and 2 (^c) A-unit to increase the residence time. The temperature at which the cells leave is 20t. The pH of the particles is 5.2' and contains 6.9% protein and 8· ι〇/〇 oil. -45- This paper scale applies to Chinese national standards ( CNS) A4 size (210 X 297 mm)

Claims (1)

1299¾晶0127151號專利申請案 g 厂一— 中文申請專利範圍替換本(97年1月）盟 r9年,吖沿 六、申請專利範圍‘ — 1 · 一種具有增稠流體態之組合物，包括： (i) 包括至少一種可形成凝膠之聚合物之第一（剪切凝 膠）相，該聚合物係以剪切凝膠（亦即分離凝膠顆粒之多 重性，其以藉由使聚合物進行剪切，同時發生凝膠形 成）存在於組合物中；及 (ii) 顆粒或液滴態之第二（包封）相，其包括對頭髮有 利之劑類，其中至少部分之顆粒或液滴包封在至少一部 份第一（剪切凝膠）相之凝膠顆粒中， 其中可形成凝膠之聚合物構成全部組合物之〇 〇4至W 重量％ 〇 2·如申請專利範圍第i項之組合物，其中天然衍生之聚合 物係選自多糖、蛋白質及其混合物。 3 ·如申明專利範圍第丨或2項之組合物，其為頭髮處理組合 物0 4·如申請專利範圍第3項之組合物，其中第二（包封）相包 括選自乳化之矽酮及過烷（烯）基烴物質之調理劑。 5.如申請專利範圍第丨或2項之組合物，其中第二（包封）相 包括選自吡啶硫酮之重金屬鹽之固態抗菌劑，較好為吡 σ定硫嗣辞。 6·如申凊專利範圍第丨或2項之組合物，其尚包括懸浮在第 一（剪切凝膠）相中之第三（懸浮）相。 7·如申請專利範圍第6項之組合物，其中第三（懸浮）相包 括選自聚乙二醇硬脂酸酯、乙二醇硬脂酸酯及塗佈二氧 化鈦雲母顆粒之珍珠光澤劑，選自乳化之矽酮及過-烷 本紙張尺舰財關家鮮(⑽）Μ規格(加〉〈撕公楚)-;--- A8 B8 C8 1299268 申請專利範圍 (烯）基烴物質之調理劑或選自吡啶硫酮之重金屬鹽，較 好為吡啶硫酮鋅之抗菌劑。 8·如申請專利範圍第1或2項之組合物，其為洗髮精組合物 且尚包括： U)全部洗髮精組合物5至30重量％之界面活性劑，及 (b)全部洗髮精組合物0 02至〇·5重量％之陽離子沉積 聚合物。 9·如申請專利範圍第1或2項之組合物，其為潤濕精且尚包 括： (a) 全部組合物0·05至5重量％之陽離子界面活性劑，及 (b) 全部組合物〇.1至5重量％之脂肪醇。 10.—種製備如申請專利範圍第丨或2項之組合物之方法，包 括形成聚合物之水溶液，使溶液與一種或多種實質上 溶於水溶液中或實質上與水溶液不互溶之對頭髮有益= 類混合，且使溶液膠凝同時施加剪力。 皿劑 -2-Patent application No. 12993⁄4 Crystal No. 0127151 g Factory 1 - Chinese patent application scope replacement (January 97) League r9 years, 吖 六 、, application patent scope '-1 · · A composition with thickened fluid state, including: (i) a first (shear gel) phase comprising at least one gel-forming polymer which is a shear gel (ie, a multiplicity of separated gel particles by which polymerization is achieved) And the second (encapsulated) phase of the granule or droplet state, comprising at least a portion of the granule or The droplets are encapsulated in at least a portion of the first (shear gel) phase of the gel particles, wherein the gel-forming polymer constitutes 〇〇4 to W% by weight of the total composition 〇2. The composition of the item i, wherein the naturally derived polymer is selected from the group consisting of polysaccharides, proteins, and mixtures thereof. 3. The composition of claim 2 or 2, which is a hair treatment composition. The composition of claim 3, wherein the second (encapsulated) phase comprises an anthrone selected from the group consisting of emulsified ketones. And a conditioner for the passage of alkane (alkenyl) hydrocarbon species. 5. The composition of claim 2 or 2 wherein the second (encapsulated) phase comprises a solid antimicrobial agent selected from the group consisting of heavy metal salts of pyrithione, preferably pyridoxine. 6. The composition of claim 2 or claim 2, further comprising a third (suspended) phase suspended in the first (shear gel) phase. 7. The composition of claim 6, wherein the third (suspended) phase comprises a pearlescent agent selected from the group consisting of polyethylene glycol stearate, ethylene glycol stearate, and coated titanium dioxide mica particles. It is selected from the group consisting of emulsified ketones and over-alkane paper tapes. The company has a specification (additional > (Tearing Chu)-;--- A8 B8 C8 1299268 The conditioning agent or a heavy metal salt selected from the group consisting of pyrithione is preferably an antibacterial agent of zinc pyrithione. 8. The composition of claim 1 or 2 which is a shampoo composition and further comprising: U) 5 to 30% by weight of all surfactants of the shampoo composition, and (b) all washes The hair essence composition is from 0 02 to 5% by weight of a cationic deposition polymer. 9. The composition of claim 1 or 2 which is a moisturizing concentrate and further comprising: (a) from 0.05 to 5% by weight of the total cationic surfactant of the composition, and (b) all of the compositions 11 to 5% by weight of fatty alcohol. 10. A method of preparing a composition according to claim 2 or 2, comprising forming an aqueous solution of a polymer which is beneficial to the hair of one or more substantially insoluble in the aqueous solution or substantially immiscible with the aqueous solution. = Class mixing and gelling the solution while applying shear. Dish -2-
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