1257425 五、發明説明（1 ) 技術領域 本發明爲關於即使於油分存在下亦顯示高起泡性， 且對於皮膚之刺激低’且歷時安定性良好之洗淨劑組成 物。 背景技術 人類皮膚直接接觸洗淨劑組成物之情況可列舉將食 用器具附著之油分予以洗淨之情況、於入浴等中使用肥 皂、洗髮精等情況。最近，將女性之彩粧化粧料、毛髮 用之造型劑等各種各樣之化粧料以洗淨劑組成物予以洗 淨之情況日漸增加。將臉和毛髮表面上之化粧料予以洗 淨時，其重要爲令化粧料以洗淨劑予以良好除去，且洗 淨時洗淨劑爲良好起泡亦爲重要。因爲，經由洗淨時良 好起泡，則可令使用者感到化粧料爲被良好除去。但是 ，以化粧料做爲洗淨對象而使用洗淨劑之情形中，其現 狀爲洗淨劑之泡沫爲非常難起泡。 於油分存在下亦可良好起泡之界面活性劑，可列舉 目前使用做爲食用器具用洗淨劑組成物之主要成分的烷 基苯磺酸酯型陰離子性界面活性劑、烷基硫酸酯型陰離 子性界面活性劑等。但是，若使用此些界面活性劑，則 有時引起皮膚粗糙，對於皮膚之剌激強。因此，最近， 傾向將此類界面活性劑不使用做爲直接接觸皮膚之洗淨 劑組成物（例如，食用器具用洗淨劑組成物等）的成分。 因此，此類界面活性劑並不適於做爲以化粧料爲洗淨對 象之洗淨劑組成物的起泡劑。 1257425 五、發明説明（2 ) 對於皮膚之刺激低、且直接接觸皮膚之洗淨劑組成 物成分之較佳的界面活性劑，爲酸醚硫酸酯型陰離子性 界面活性劑、醯基牛磺酸酯型陰離子性界面活性劑等。 使用酸醚硫酸酯型陰離子性界面活t$劑之洗淨劑組 成物，已知於醯醚硫酸酯型陰離子性界面活性劑中組合 下列界面活性劑等之組成物：將胺基酸系界面活性劑和 兩性界面活性劑組合之組成物（特開平1 0 - 1 8 2 3 6 7號公 報）；將醯胺甜菜鹼型兩性界面活性劑組合之組成物（特 開平6-2 9 3 62 0號公報）；將咪唑鏺甜菜鹼型兩性界面活 性劑組合之組成物（特開平6-49484號公報）；將醯甲基 牛磺酸酯型陰離子性界面活性劑和醯胺基胺酸型兩性界 面活性劑組合之組成物（特開平6- 1 86792號公報）；將 絲衍生多肽之醯化物鹽組合之組成物（特開平5 - 4 3 8 8 9 號公報）；將烷基糖苷型非離子性界面活性劑組合之組 成物（特開平4- 1 26799號公報）等。 使用醯基牛磺酸酯型陰離子性界面活性劑之組成物 ，已知醯基牛磺酸酯型陰離子性界面活性劑中組合以之 界面活性劑等之組成物：將醯胺醚硫酸酯型陰離子性界 面活性劑和醯胺基胺基酸型兩性界面活性劑組合之組成 物（特開平4- 1 5298號公報）；將甜菜鹼系界面活性劑、 和HLB爲1 0〜1 6之非離子性界面活性劑、和烷醇醯胺 型離子性界面活性劑或胺氧化物型非離子性界面活性劑 、和聚（二甲基二烯丙基銨鹵化物）型陽離子性高分子化 合物組合之組成物（特開平3-93 7 1 1號公報）；將醯胺基 -4- 1257425 五、發明説明（3 ) 磺基甜菜鹼型兩性界面活性劑或磺基甜菜鹼型兩性界面 活性劑和烷醇醯胺型非離子性界面活性劑組合之組成物 (特開平3 -48608號公報）；磺基琥珀酸酯鹽型陰離子性 界面活性劑組合之組成物（特開平2-10/ 894號公報）； 將烷基糖苷型非離子性界面活性劑組合之組成物（特開 平1 - 1 78 5 96號公報）。 上述之醯胺醚硫酸酯型陰離子性界面活性劑及醯基 牛磺酸酯型陰離子性界面活性劑，於洗淨汗等之水溶性 成分之情形中雖顯示較高之起泡性，但在洗淨化粧料和 食用器具所附著之油分對象之情形中，則具有起泡性顯 著降低之缺點。將此些界面活性劑與上述其他界面活性 劑組合之洗淨劑組成物亦無法解除此缺點。更且，經由 此些界面活性劑與上述其他界面活性劑之組合，則於低 溫下發生固化及沈澱物、於高溫下著色等之歷時安定性 上多具有問題。 因此，實際狀況爲仍未取得於油分存在下顯示高起 泡性，且對於皮膚之刺激低，且歷時安定性良好之洗淨 劑組成物。 另一方面，沐浴精等之身體洗淨劑一般爲使用高級 脂肪酸鹽做爲基劑的洗淨劑。高級脂肪酸鹽爲具有高洗 淨力，洗淨後無滑溜感，洗後之乾爽感優良，起泡及泡 質良好，但擔心脫脂力強、對於皮膚之刺激強之問題。 於是，以高級脂肪酸鹽做爲基劑之身體洗淨劑，一般爲 了緩和皮膚刺激性，乃多倂用其他界面活性劑。例如， -5- 1257425 五、發明説明（4 ) 已知於高級脂肪酸鹽中組合下列界面活性劑等之組成物 :將醯胺醚硫酸酯型陰離子性界面活性劑和烷基磷酸酯 型陰離子性界面活性劑組合之組成物特開平5 - 2 0 1 8 5 2 號公報）；將月桂酸鹽和二級醯胺型N:_基胺基酸鹽組 合之組成物（特開平5 - 1 5 62 84號公報）；將月桂酸鉀、 肉豆蔻酸鉀或油酸鉀、和聚氧乙烯蓖麻油組合之組成物 (特開昭6 1 -300號公報將脂肪酸鹽和鄰-取代蘋果酸 組合之組成物（特開昭59- 1 5 5 00號公報）；將脂肪酸之 三乙醇胺鹽和醯基戊二酸酯型陰離子性界面活性劑組合 之組成物（特開昭61 _2 8 7992號公報）；將脂肪酸鹽和羥 乙基纖維素陽離子化合物組合之組成物（特開昭8-1 67699號公報）等。 又，亦嘗試將高級脂肪酸以鹼性胺基酸予以中和， 緩和皮膚刺激性。例如，已知使用高級脂肪酸之鹼性胺 基酸鹽等之下列組成物：將脂肪酸鹼性胺基酸鹽和Θ -丙胺酸型兩性界面活性劑組合之組成物（特開平9-1 5 1 3 9 1號公報）；將脂肪酸鹼性胺基酸鹽和胺氧化物組 合之組成物（特開平9- 1 1 8896號公報）等。 更且，於特開平5-26263 9號公報和特開平9- 1 3 096 號公報中，揭示將脂肪酸鹽和聚乙二醇和特定之非離子 性界面活性劑組合且令皮膚刺激減低爲其目的之洗淨劑 組成物。 根據此類檢討，雖然令高級脂肪酸鹽做爲基劑之身 體洗淨劑的皮膚刺激性問題受到改善，但依然殘留高級 -6- 1257425 五、發明説明（f ) 脂 肪 酸鹽 做 爲基 劑 之身體洗 淨劑 於使 用後令皮膚乾燥之 問 題 。高 級 脂肪 酸 鹽之pH爲弱鹼性- -鹼性， 因爲脫脂 力 較 強， 故 根據 所 使用之人 ，或根據 季節或 使用頻率， 於 程 度上 雖 有差 異 ，但於洗 淨後 具有 易令皮 < 膚乾燥之問 題 〇 關 於皮 膚 之乾 燥 ，最近特 別成 爲問 題者爲 照顧年長 者 所 攜帶 的 看護 者 (助手）。j 比類: 看護: 者（助手 )爲1曰進 行 數 回〜十數回輔助年長者入浴， 、身體洗淨1 ，若使用先 刖 的洗淨 劑 ，則 Μ j\\\ 法避免手 部皮 膚之 乾燥、 引起皮膚粗 糙 且多 必 須以 保 濕霜等予 以護 理。 乾 燥皮 膚 的特 徵 屢屢於外 觀上 察見 落屑和 龜裂，老 的 角 質層 不 會剝 離 ，且角質 於皮 膚上 滯留堆 積，且視情 況 發 癢。 將 此類 乾 燥皮膚之 表面 角細 胞以深 剝皮法 (Deep-stripping) 採 集並若以 顯微 鏡觀 察，則 察見許多 形狀 顯著 歪 斜和 殘 存核之不 全角 化。 又，若 測定皮膚之 導 電 度， 則於許 多 情況察見 導電 度降 低，且 得知水分量 減 少 。由 此 推測 保持水分 且防 止異 物侵入 之角質層本 來 之 機能 降 低。 空 氣乾燥之 冬季 特別 易引起 洗淨後之皮 膚 乾 燥。 將 甘油 等 之保 濕 劑、植物 油和 角鯊 烯等之 柔軟劑、 胺 基 酸和 α-羥基 酸 或其衍生 物之 保濕 成分、 或聚氧乙 二 醇 和聚 氧 乙烯 山 梨糖醇酐 系非 離子 性界面活性劑配合 至 洗 淨劑 嘗試 抑 制洗淨所 造成 之皮 膚乾燥 ，並且保持 濕 潤 。但 是 ，其亦不能稱爲 具有充分的效果 7- 〇 1257425 五、發明説明（6 ) 於是，期望即使於油分存在下亦具有高起泡性、優 良之泡質及保存安定性，且對於皮膚之刺激低’洗淨後 之觸感乾爽，且即使頻繁使用亦少引起皮膚之乾燥’並 且可保持皮膚濕潤之洗淨劑組成物。 發明之揭示 本發明爲提供含有以下之a和b，且含有a爲5〜3 5 重量％、b爲0.5〜20重量％，a/b之重量比爲3/4〜10/1 爲其特徵之洗淨劑組成物。於此洗淨劑組成物中，a爲 由高級脂肪酸鹽（al)、醯胺醚硫酸酯型陰離子性界面活 性劑（a2)、及醯基牛磺酸酯型陰離子性界面活性劑（a3) 所組成群中選出之至少一種，b爲十一碳烯酸醯胺醋酸 甜菜鹼型兩性界面活性劑。 於較佳之本實施態樣中，前述洗淨劑組成物爲洗臉 材料，a爲高級脂肪酸鹽（al)，含有al爲15〜35重量％ 1^爲0.5〜10重量％，&1+1)爲20〜45重量％，&1/1)之重量 比爲3/1〜10/1 。 、 於其他之較佳實施態樣中，前述洗淨劑組成物爲沐 浴精，a爲高級脂肪酸鹽（al)，含有al爲5〜35重量％ 、1)爲0.5〜15重量％，al+b爲10〜4 0重量％，al/b之重 -8- 1257425 五'發明説明（7 ) 量比爲2/1〜10/1。 更且，於再其他之實施態樣中，前述洗淨劑組成物 爲廚房用洗劑，a爲醯胺醚硫酸酯型陰離子性界面活性 劑（a2)或醯基牛磺酸酯型陰離子性界面活性劑（a3)，含 有a爲5〜30重量％、1)爲0.5〜20重量％，a + b爲10〜45 重量％，a/b之重量比爲3/4〜8/1。 於其他之較佳實施態樣中，前述洗淨劑組成物爲洗 髮精，a爲醯胺醚硫酸酯型陰離子性界面活性劑（a2)或 醯基牛磺酸酯型陰離子性界面活性劑（a3)，含有a爲 5〜20重量％、b爲0.5〜20重量％，a + b爲6〜30重量％， a/b之重量比爲3/4〜5/1。 用以實施發明之最佳型態 本發明之洗淨劑組成物爲令a :高級脂肪酸鹽（al)、 醯胺醚硫酸酯型陰離子性界面活性劑（a2)、及醯基牛磺 酸酯型陰離子性界面活性劑（a3)所組成群中選出至少一 種、和b :十一碳烯酸醯胺醋酸甜菜鹼型兩性界面活性 劑含有指定份量，其他，含有水及洗淨劑組成物中所必 要之添加劑的洗淨劑組成物。 (高級脂肪酸（al)) 冬 1257425 五 '發明説明（8 ) a 1所示之高級脂肪酸鹽中，較佳使用下列式（1)所示 之高級脂肪酸鹽。 ^ R 1 C 〇 Ο Μ 1 (1) 式中’ R^CO爲碳數8〜22個之脂族_基，Μ1爲表示 氫原子、鹼金屬、銨、有機銨、胺基酸、胺基酸鹽、牛 擴酸、牛磺酸鹽、Ν -甲基牛磺酸或Ν -甲基牛磺酸鹽。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a detergent composition which exhibits high foaming property even in the presence of oil, and which is low in irritation to the skin and which has good stability over time. Background of the Invention When the human skin is directly in contact with the detergent composition, the oil component to which the food device is attached may be washed, and the soap or shampoo may be used in the bath or the like. Recently, various cosmetic materials such as women's makeup cosmetics and hair styling agents have been washed with a detergent composition. When the cosmetic on the face and the surface of the hair is washed, it is important that the cosmetic is well removed by the detergent, and it is also important that the detergent is good foaming during washing. Since the foaming is good by washing, the user feels that the cosmetic material is well removed. However, in the case where a cosmetic is used as a target for washing, the foam which is present as a detergent is very difficult to foam. A surfactant which can be well foamed in the presence of an oil, and an alkylbenzenesulfonate type anionic surfactant or an alkyl sulfate type which is currently used as a main component of a detergent composition for edible utensils An anionic surfactant and the like. However, if such a surfactant is used, it may cause rough skin and may be irritating to the skin. Therefore, recently, it has been tended to use such a surfactant as a component of a detergent composition (e.g., a detergent composition for food appliances, etc.) which is in direct contact with the skin. Therefore, such a surfactant is not suitable as a foaming agent for a detergent composition in which a cosmetic is a cleansing object. 1257425 V. INSTRUCTIONS (2) A preferred surfactant for the composition of the detergent composition having low skin irritation and direct contact with the skin is an acid ether sulfate type anionic surfactant, sulfhydryl taurine An ester type anionic surfactant or the like. A detergent composition using an acid ether sulfate type anionic interface t$ agent, which is known to be combined with a composition of the following surfactants in an oxime ether sulfate type anionic surfactant: an amino acid interface A composition of an active agent and an amphoteric surfactant combination (Japanese Unexamined Patent Publication No. Hei No. Hei No. Hei No. Hei No. Hei No. Hei. No. 0); a composition in which an imidazolium betaine type amphoteric surfactant is combined (JP-A-6-49484); an anthraquinone-type anionic surfactant and an amidino-amine type A composition of a combination of an amphoteric surfactants (JP-A-6-186792); a composition in which a telluride salt of a silk-derived polypeptide is combined (JP-A-5-38 8-9) A composition of a nonionic surfactant combination (Japanese Unexamined Patent Application Publication No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No. No A composition of a sulfhydryl taurate-type anionic surfactant is known, and a composition of a surfactant such as a sulfonium taurate-type anionic surfactant is known: a guanamine ether sulfate type A composition of an anionic surfactant and a amide amino acid type amphoteric surfactant combination (Japanese Unexamined Patent Publication No. Hei No. Hei-4- No. Hei No. Hei No. Hei No. Hei No. Hei No. Hei. An ionic surfactant, a combination of an octanolamine type ionic surfactant or an amine oxide type nonionic surfactant, and a poly(dimethyldiallylammonium halide) type cationic polymer compound Composition (Japanese Unexamined Patent Publication No. Hei No. 3-93 7 1 1); amide amino-4- 1257425 V. Description of Invention (3) Sulfobetaine type amphoteric surfactant or sulfobetaine type amphoteric surfactant A composition in combination with an alkanohydrazide-type nonionic surfactant (JP-A-3-48608); a composition of a sulfosuccinate-type anionic surfactant combination (Special Kaiping 2-10/894) No.); alkanoside-type non-ion The composition of the surfactant composition (JP Kaiping 1--1785 Publication 96). The above-described indoleamine sulfate type anionic surfactant and the mercapto taurate type anionic surfactant exhibit high foaming properties in the case of washing a water-soluble component such as sweat, but In the case of washing the cosmetic material and the oil component to which the edible utensil is attached, there is a disadvantage that the foaming property is remarkably lowered. The detergent composition which combines these surfactants with the above other surfactants also does not relieve this disadvantage. Further, the combination of these surfactants and the above-mentioned other surfactants has a problem in that the curing at a low temperature, the precipitation of the precipitate, the coloring at a high temperature, and the like are often problematic. Therefore, the actual condition is a detergent composition which exhibits high foaming property in the presence of oil, and which is low in irritation to the skin and has good stability over time. On the other hand, body cleansers such as bath essence are generally detergents using a high-grade fatty acid salt as a base. The high-grade fatty acid salt has a high detergency, has no slipperiness after washing, has a good dry feeling after washing, and has good foaming and foaming properties, but is worried about strong degreasing power and strong skin irritation. Therefore, body detergents based on higher fatty acid salts are generally used to alleviate skin irritation, and other surfactants are used. For example, -5-1257425 V. DESCRIPTION OF THE INVENTION (4) It is known to combine a composition of the following surfactants and the like in a higher fatty acid salt: an anthraquinone sulfate type anionic surfactant and an alkyl phosphate type anionic property The composition of the surfactant combination is disclosed in Japanese Patent Laid-Open No. Hei 5 - 2 0 1 8 5 2; a composition combining laurate and a second guanamine type N:-aminoamine salt (Special Kaiping 5 - 15) 62 No. 84); a composition combining potassium laurate, potassium myristate or potassium oleate, and polyoxyethylene castor oil (Japanese Unexamined Patent Publication No. Hei No. Hei No. Hei No. Hei No. 6-300 discloses a combination of a fatty acid salt and an o-substituted malic acid a composition of the combination of a triethanolamine salt of a fatty acid and an anionic surfactant of a decyl glutarate type (Japanese Unexamined Patent Application Publication No. Hei No. Hei No. Hei No. Hei No. Hei No. Hei No. Hei. A composition in which a fatty acid salt and a hydroxyethyl cellulose cationic compound are combined (JP-A-A-8-1 67699), etc. Further, it is also attempted to neutralize a higher fatty acid with a basic amino acid to alleviate skin irritation. For example, it is known to use a basic amine group of a higher fatty acid. a composition of a salt or the like: a composition in which a fatty acid basic amino acid salt and a hydrazine-alanine type amphoteric surfactant are combined (Japanese Unexamined Patent Publication No. Hei 9-1 5 1 3 9 1); A composition of a combination of an amino acid salt and an amine oxide is disclosed in Japanese Laid-Open Patent Publication No. Hei. No. Hei. No. Hei. No. Hei. A combination of a fatty acid salt and a polyethylene glycol and a specific nonionic surfactant to reduce skin irritation to a detergent composition for its purpose. According to this review, the body is washed with a higher fatty acid salt as a base. The skin irritation problem of the agent is improved, but still remains high. -6- 1257425 V. Inventive Note (f) The body detergent as a base is used to dry the skin after use. The pH of the higher fatty acid salt is Weakly alkaline - Alkaline, because of the strong degreasing power, depending on the person used, or according to the season or frequency of use, although there are differences in degree, but after washing, it has easy to make skin <The problem is about the dryness of the skin, and the caregiver (assistant) carried by the elderly person who has recently become a problem. j: Class: Nursing: The assistant (assistant) carries out a number of times for ~1 times to assist the elderly to bathe, Wash your body 1. If you use a sputum detergent, Μ j\\\ method to avoid dry skin, cause rough skin and more need to take care of moisturizing cream. The characteristics of dry skin are often observed on the appearance of chipping and cracking. The old cuticle will not peel off, and the keratin will remain on the skin and itching will occur depending on the condition. The surface cells of such dry skin are collected by deep-stripping and, if observed by microscopy, many of the shapes are significantly skewed and the residual nuclei are not fully keratinized. Also, if the skin conductance is measured, the conductivity is lowered in many cases, and the amount of water is reduced. It is presumed that the native layer of the stratum corneum, which retains moisture and prevents foreign matter from entering, is reduced. In the winter when the air is dry, it is especially easy to cause the skin after washing to dry. A moisturizing agent such as glycerin, a softening agent such as vegetable oil and squalene, a moisturizing component of an amino acid and an α-hydroxy acid or a derivative thereof, or a polyoxyethylene glycol and a polyoxyethylene sorbitan-based nonionic substance. The surfactant is incorporated into the detergent to attempt to inhibit dryness of the skin caused by the wash and to keep it moist. However, it cannot be said to have sufficient effect. 7- 1257425 V. Inventive Note (6) Therefore, it is desired to have high foaming property, excellent foam quality and preservation stability even in the presence of oil, and for skin It is a low-stimulus detergent composition that is dry after washing, and which causes dryness of the skin even if it is frequently used, and keeps the skin moist. DISCLOSURE OF THE INVENTION The present invention provides a and b containing the following, and contains a of 5 to 35 wt%, b of 0.5 to 20 wt%, and a/b weight ratio of 3/4 to 10/1. The detergent composition. In the detergent composition, a is a higher fatty acid salt (al), a guanamine ether sulfate type anionic surfactant (a2), and a mercapto taurate type anionic surfactant (a3) At least one selected from the group consisting of b is an undecylenic acid decylamine acetate betaine type amphoteric surfactant. In a preferred embodiment, the detergent composition is a face washing material, a is a higher fatty acid salt (al), and contains 15 to 35 wt% of al 1 to 0.5 to 10 wt%, & 1+1. ) is 20 to 45 wt%, and the weight ratio of &1/1) is 3/1 to 10/1. In another preferred embodiment, the detergent composition is bath essence, a is a higher fatty acid salt (al), containing al 5 to 35 wt%, 1) 0.5 to 15 wt%, al+ b is 10 to 40% by weight, and the weight of al/b is -8 - 1257425. 5 'Invention Description (7) The ratio is 2/1 to 10/1. Furthermore, in still other embodiments, the detergent composition is a kitchen lotion, and a is a guanamine ether sulfate type anionic surfactant (a2) or a sulfhydryl taurate type anionic. The surfactant (a3) contains a 5 to 30% by weight, 1) 0.5 to 20% by weight, a + b of 10 to 45% by weight, and a/b weight ratio of 3/4 to 8/1. In other preferred embodiments, the detergent composition is a shampoo, and a is a guanamine ether sulfate type anionic surfactant (a2) or a sulfhydryl tauryl ester type anionic surfactant. (a3), a is 5 to 20% by weight, b is 0.5 to 20% by weight, a + b is 6 to 30% by weight, and the weight ratio of a/b is 3/4 to 5/1. BEST MODE FOR CARRYING OUT THE INVENTION The detergent composition of the present invention is such that a: a higher fatty acid salt (al), a guanamine ether sulfate type anionic surfactant (a2), and a mercapto taurate At least one selected from the group consisting of an anionic surfactant (a3), and b: an undecylenoic acid betaine type amphoteric surfactant containing a specified amount, and other, containing water and a detergent composition A detergent composition of the necessary additives. (Advanced fatty acid (al)) Winter 1257425 5 'Inventive description (8) Among the higher fatty acid salts shown by a1, the higher fatty acid salt represented by the following formula (1) is preferably used. ^ R 1 C 〇Ο Μ 1 (1) where R ^CO is an aliphatic group of 8 to 22 carbon atoms, and Μ 1 represents a hydrogen atom, an alkali metal, an ammonium, an organic ammonium, an amino acid, or an amine group. An acid salt, bovine acid, taurate, hydrazine-methyl taurine or hydrazine-methyl taurate.
RkO爲碳數8〜22個之脂族醯基，可列舉例如辛醯 基、癸醯基、月桂醯基、肉豆蔻醯基、棕櫚醯基、硬脂 醯基、油醯基、亞油醯基、山窬醯基等。具有此些基之 高級脂肪酸鹽亦可存在數種，例如，R 1 C 0爲來自椰子 油脂肪酸、棕櫚仁油脂肪酸、向日葵油脂肪酸、牛脂脂 肪酸等之脂族醯基殘基。 鹼金屬可列舉例如鋰、鈉、鉀。 有機銨可列舉例如單乙醇銨、二乙醇銨、三乙醇銨。 胺基酸可列舉例如天冬胺酸、麩胺酸等之酸性胺基 酸；甘胺酸、肌胺酸、丙胺酸、A -丙胺酸、苯基丙胺 酸、纈胺酸、白胺酸、異白胺酸、蘇胺酸、甲硫胺酸、 茶胺酸、絲胺酸、脯胺酸、r -胺基丁酸、r -胺基戊酸 等之中性胺基酸；精胺酸、鳥胺酸、組胺酸、離胺酸、 色胺酸等之鹼性胺基酸。又，胺基酸鹽可列舉此些胺基 酸與鹼金屬、銨或有機銨之鹽。 牛磺酸鹽可列舉牛磺酸之鹼金屬鹽、銨鹽、或有機 銨鹽。可列舉例如牛磺酸鈉、牛磺酸鉀等。 N -甲基牛磺酸鹽可列舉N -甲基牛磺酸之鹼金屬鹽、 -10- 1257425 五、發明説明（9 ) 銨鹽、或有機銨鹽。可列舉例如N -甲基牛磺酸鈉、N ~ 甲基牛磺酸鉀等。 (醯胺醚硫酸酯型陰離子性界面活性劑..(a2)) a2所示之醯胺醚硫酸酯型陰離子性界面活性劑中， 亦較佳使用下列式（2)所示之醯胺醚硫酸酯型陰離子性 界面活性劑。 R2C0NH(C2H40)nS03M2 (2) 式中’ R2CO爲碳數8〜22個之脂族醯基，η爲1〜1〇 ，Μ2爲表不氫原子、鹼金屬、鹼土金屬、銨、有機銨 、鹼性胺基酸、牛磺酸鹽、Ν-甲基牛磺酸鹽、中性或 酸性胺基酸鹽。 碳數8〜22個之脂族醯基可列舉月桂醯基、肉豆蔻醯 基、棕櫚醯基、硬脂醯基、油醯基等。具有此些基之醯 胺醚硫酸酯型陰離子性界面活性劑亦可存在數種，例如 ，R2CO爲來自椰子油脂肪酸、棕櫚仁油脂肪酸、牛脂 脂肪酸等之脂族醯基殘基。脂族醯基之碳數爲7個以下 ，則對於皮膚之刺激變強，且具有起泡性降低之傾向。 碳數爲23個以上則有起泡性、歷時安定性降低之傾向。 η爲表示氧乙烯基的平均加成莫耳數，且以1〜10爲 佳◦更佳爲2〜6。η未滿1，則對於皮膚之刺激變強， 且具有歷時安定性降低之傾向，若超過1 〇則具有起泡 性降低之傾向。 Μ 1之鹼金屬可列舉鈉、鉀等。鹼土金屬可列舉1 / 2 鈣、1/2鎂。 -11- 1257425 五、發明説明（1G ) 有機銨可列舉三乙醇銨等。 鹼性胺基酸可列舉離胺酸、精胺酸。 牛磺酸鹽可列舉牛磺酸之鹼金屬鹽、鹼土金屬鹽、銨 鹽、或有機銨鹽。可列舉例如牛磺酸_、牛磺酸鉀等。 N-甲基牛磺酸鹽可列舉N-甲基牛磺酸之鹼金屬鹽、 鹼土金屬鹽、銨鹽、或有機銨鹽◦可列舉例如N-甲基 牛磺酸鈉、N-甲基牛磺酸鉀等。 中性或酸性胺基酸鹽可列舉中性或酸性胺基酸之鹼 金屬鹽、鹼土金屬鹽、銨鹽、或有機銨鹽。可列舉例如 甘胺酸鈉、甘胺酸鉀、肌胺酸鈉、yS -丙胺酸鈉等之中 性胺基酸鹽、麩胺酸二鈉、麩胺酸二鉀、天冬胺酸二鈉 等之酸性胺基酸鹽。 式（2)所示之醯胺醚硫酸酯型陰離子性界面活性劑之 具體例可列舉下列之界面活性劑：聚氧乙烯（2莫耳）月 桂酸醯胺醚硫酸鈉；聚氧乙烯（3莫耳）月桂酸醯胺醚硫 酸鉀；聚氧乙烯（4莫耳）月桂酸醯胺醚硫酸銨；聚氧乙 烯（4莫耳）肉豆蔻酸醯胺醚硫酸鈉；聚氧乙烯（5莫耳） 棕櫚酸醯胺醚硫酸鈉；聚氧乙烯（6莫耳）硬脂酸醯胺醚 硫酸鈉；聚氧乙烯（5莫耳）油酸醯胺醚硫酸鈉；聚氧乙 烯（4莫耳）椰子油脂肪酸醯胺醚硫酸鈉；聚氧乙烯（4莫 耳）椰子油脂肪酸醯胺醚硫酸鉀；聚氧乙烯（4莫耳）椰子 油脂肪酸醯胺醚硫酸鎂；聚氧乙烯（4莫耳）椰子油脂肪 酸醯胺醚硫酸三乙醇銨；聚氧乙烯（4莫耳）椰子油脂肪 酸醯胺醚硫酸精胺酸；聚氧乙烯（4莫耳）椰子油脂肪酸 -12- 1257425 五 '發明説明（11 ) si胺ϋ硫酸和牛磺酸鈉之鹽；聚氧乙烯（4莫耳）椰子油 脂肪酸醯胺醚硫酸和Ν:甲基牛磺酸鈉之鹽；聚氧乙烯 (4莫耳）椰子油脂肪酸醯胺醚硫酸和麩胺酸二鈉之鹽； @氧乙儲（3莫耳）棕櫚仁油脂肪酸醯胺醚硫酸鈉；聚氧 乙_ (4莫耳）棕櫚仁油脂肪酸醯胺醚硫<酸離胺酸；聚氧 乙烯（3莫耳）棕櫚仁油脂肪酸醯胺醚硫酸鎂；聚氧乙烯 (3莫耳）棕櫚仁油脂肪酸醯胺醚硫酸和牛磺酸鈉之鹽； 聚氧乙烯（3莫耳）棕櫚仁油脂肪酸醯胺醚硫酸和Ν_甲基 牛磺酸鈉之鹽；聚氧乙烯（3莫耳）棕櫚仁油脂肪酸醯胺 醚硫酸和甘胺酸鈉之鹽；聚氧乙烯（6莫耳）牛脂脂肪酸 醯胺醚硫酸鈉等。 (醯基牛磺酸酯型陰離子性界面活性劑（a3)) a3所示之醯基牛磺酸酯型陰離子性界面活性劑中， 亦較佳使用下列式（3)所示之醯基牛磺酸酯型陰離子性 界面活性劑。 R2C0N(CH2)2S03M2 (3)RkO is an aliphatic fluorenyl group having 8 to 22 carbon atoms, and examples thereof include a octyl group, a fluorenyl group, a lauryl group, a myristyl group, a palmitoyl group, a stearin group, an oil group, a linoleyl group, Hawthorn and so on. There may also be several higher fatty acid salts having such a group. For example, R 1 C 0 is an aliphatic sulfhydryl residue derived from coconut oil fatty acid, palm kernel oil fatty acid, sunflower oil fatty acid, tallow fatty acid or the like. Examples of the alkali metal include lithium, sodium, and potassium. Examples of the organic ammonium include monoethanolammonium, diethanolammonium, and triethanolammonium. Examples of the amino acid include acidic amino acids such as aspartic acid and glutamic acid; glycine, sarcosine, alanine, A-alanine, phenylalanine, valine, and leucine. Neutral amino acid such as isoleucine, sulphate, methionine, theanine, serine, valine, r-aminobutyric acid, r-aminopentanoic acid; arginine A basic amino acid such as ornithine, histidine, lysine or tryptophan. Further, the amine acid salt may, for example, be a salt of such an amino acid with an alkali metal, ammonium or organic ammonium. The taurate salt may, for example, be an alkali metal salt, an ammonium salt or an organic ammonium salt of taurine. For example, sodium taurate, potassium taurine, etc. are mentioned. The N-methyltaurine salt may, for example, be an alkali metal salt of N-methyltaurine, -10- 1257425, an invention (9) an ammonium salt or an organic ammonium salt. For example, sodium N-methyltaurate, potassium N-methyltaurate, etc. are mentioned. (Amidoxime sulfate type anionic surfactant: (a2)) In the amidoxime sulfate type anionic surfactant represented by a2, the indoleamine represented by the following formula (2) is also preferably used. Sulfate type anionic surfactant. R2C0NH(C2H40)nS03M2 (2) where R2CO is an aliphatic sulfhydryl group having 8 to 22 carbon atoms, η is 1 to 1 〇, and Μ2 is a hydrogen atom, an alkali metal, an alkaline earth metal, an ammonium, an organic ammonium, Basic amino acid, taurate, Ν-methyl taurate, neutral or acidic amino acid salt. The aliphatic thiol group having 8 to 22 carbon atoms may, for example, be a lauryl sulfonyl group, a myristyl group, a palmitoyl group, a stearyl group or an oil group. There may be several kinds of amine ether sulfate type anionic surfactants having such a group. For example, R2CO is an aliphatic sulfhydryl residue derived from coconut oil fatty acid, palm kernel oil fatty acid, tallow fatty acid or the like. When the number of carbon atoms of the aliphatic sulfhydryl group is 7 or less, the irritation to the skin becomes strong, and the foaming property tends to be lowered. When the number of carbon atoms is 23 or more, the foaming property tends to decrease and the stability over time tends to decrease. η is an average addition molar number indicating an oxyethylene group, and more preferably 1 to 10 is 2 to 6. When η is less than 1, the irritation to the skin becomes strong, and the stability over time tends to be lowered. When it exceeds 1 〇, the foaming property tends to decrease. The alkali metal of Μ 1 may, for example, be sodium or potassium. The alkaline earth metal may be 1/2 calcium or 1/2 magnesium. -11- 1257425 V. Description of Invention (1G) Examples of the organic ammonium include triethanolammonium and the like. The basic amino acid may be exemplified by aminic acid or arginine. The taurate salt may, for example, be an alkali metal salt of an oresulfonic acid, an alkaline earth metal salt, an ammonium salt or an organic ammonium salt. For example, taurine _, potassium taurine or the like can be mentioned. The N-methyltaurine salt may, for example, be an alkali metal salt, an alkaline earth metal salt, an ammonium salt or an organic ammonium salt of N-methyltaurine, and examples thereof include sodium N-methyltaurate and N-methyl. Potassium taurate and the like. The neutral or acidic amino acid salt may, for example, be an alkali metal salt, an alkaline earth metal salt, an ammonium salt or an organic ammonium salt of a neutral or acidic amino acid. Examples thereof include a neutral amino acid salt such as sodium glycinate, potassium glycinate, sodium sarcosinate, and sodium yS-alaninate; disodium glutamate, dipotassium glutamate, and disodium aspartate. Acidic acid acid salt. Specific examples of the indoleamine sulfate type anionic surfactant represented by the formula (2) include the following surfactants: polyoxyethylene (2 mol) sodium laurate decyl ether sulfate; polyoxyethylene (3) Mohr) potassium laurate sulphate ether; polyoxyethylene (4 mol) ammonium laurate ammonium sulphate ether; polyoxyethylene (4 mol) sodium decyl sulphonate; polyoxyethylene (5 Mo Ear) sodium decyl ether palmitate; polyoxyethylene (6 mol) sodium decyl ether stearate; polyoxyethylene (5 mol) sodium oleate oleate; polyoxyethylene (4 mol) ) coconut oil fatty acid sodium amidate sulfate; polyoxyethylene (4 moles) coconut oil fatty acid guanamine ether potassium sulfate; polyoxyethylene (4 moles) coconut oil fatty acid guanamine ether sulfate; polyoxyethylene (4 Mo Ear) coconut oil fatty acid guanamine ether triethanolammonium sulfate; polyoxyethylene (4 mol) coconut oil fatty acid guanamine ether sulphate sulphate; polyoxyethylene (4 mol) coconut oil fatty acid -12- 1257425 five 'invention Description (11) salt of sulphonic acid and sodium taurate; polyoxyethylene (4 mole) coconut oil Fatty acid indoleamine sulfuric acid and hydrazine: sodium methyl taurate salt; polyoxyethylene (4 mole) coconut oil fatty acid guanamine ether sulfuric acid and glutamic acid disodium salt; @ oxygen B storage (3 moles Palm kernel oil fatty acid sodium amidate sulfate; polyoxyethylene _ (4 moles) palm kernel oil fatty acid guanamine ether sulfur < acid lysine; polyoxyethylene (3 mole) palm kernel oil fatty acid guanamine ether Magnesium sulfate; polyoxyethylene (3 mol) palm kernel oil fatty acid guanamine ether sulfuric acid and sodium taurate salt; polyoxyethylene (3 mol) palm kernel oil fatty acid guanamine ether sulfuric acid and hydrazine _ methyl taurine Sodium salt; polyoxyethylene (3 mol) palm kernel oil fatty acid guanamine ether sulfuric acid and sodium glycinate; polyoxyethylene (6 mol) tallow fatty acid guanamine ether sulfate. (Mercapto-tauryl-type anionic surfactant (a3)) Among the mercapto-tauryl-type anionic surfactants represented by a3, the thiol cattle represented by the following formula (3) are preferably used. A sulfonate type anionic surfactant. R2C0N(CH2)2S03M2 (3)
I R3 式中，R2CO及Μ2爲表示同前述式（2)之基，R3爲表 示氫原子或碳數1〜3個之院基。 式（3)之R2CO之較佳的醯基可例示與式（2)相同之基 。碳數爲7個以下，則對於皮膚之刺激變強，具有令起 泡性降低之傾向，碳數爲2 3個以上，則具有令起泡性 降低之傾向。 R3爲氫原子或碳數1〜3個之院基。碳數1〜3個之院 -13- 1257425 五、發明説明（12 ) 基可列舉甲基、乙基、及丙基。 M2之種類、及較佳；^例示亦與前述式（2)中之情況相 同。 前述式（3)所示之醯基牛磺酸酯型陰 <離子性界面活性 劑之具體例可列舉下列之界面活性劑；月桂醯甲基牛磺 酸鈉；月桂醯甲基牛磺酸鉀；月桂醯丙基牛磺酸鈉；肉 豆蔻醯甲基牛磺酸鈉；棕櫚醯甲基牛磺酸鈉；硬脂醯甲 基牛磺酸鈉；油醯甲基牛磺酸鈉；椰子油脂肪酸醯基牛 磺酸鈉；椰子油脂肪酸醯甲基牛磺酸鈉；椰子油脂肪酸 醯甲基牛磺酸鉀；椰子油脂肪酸醯甲基牛磺酸鎂；椰子 油脂肪酸醯甲基牛磺酸三乙醇銨；椰子油脂肪酸醯甲基 牛磺酸和牛磺酸鈉之鹽；椰子油脂肪酸醯甲基牛磺酸和 N-甲基牛磺酸鈉之鹽；椰子油脂肪酸醯甲基牛磺酸和 麩胺酸二鈉之鹽；棕櫚仁油脂肪酸醯基牛磺酸鈉；棕櫚 仁油脂肪酸醯甲基牛磺酸鈉；棕櫚仁油脂肪酸醯甲基牛 磺酸離胺酸鹽；棕櫚仁油脂肪酸醯甲基牛磺酸鎂；棕櫚 仁油脂肪酸醯甲基牛磺酸和牛磺酸鈉之鹽；棕櫚仁油脂 肪酸醯甲基牛磺酸和N-甲基牛磺酸鈉之鹽；棕櫚仁油 脂肪酸醯甲基牛磺酸和甘胺酸鈉之鹽；牛脂脂肪酸醯甲 基牛磺酸鈉等。 (十一碳烯酸醯胺醋酸甜菜鹼型兩性界面活性劑（b)) b所示之十一碳烯酸醯胺醋酸甜菜鹼型兩性界面活性 劑中，較佳使用下列式（4)所示之十一碳烯酸醯胺醋酸 甜菜鹼型兩性界面活性劑。 -14· 1257425 五、發明説明（13 ) R4In the formula I R3, R2CO and Μ2 are groups representing the above formula (2), and R3 is a hospital group having a hydrogen atom or a carbon number of 1 to 3. A preferred fluorenyl group of R2CO of the formula (3) can be exemplified by the same group as the formula (2). When the number of carbon atoms is 7 or less, the irritation to the skin becomes strong, and the foaming property tends to be lowered. When the number of carbon atoms is 23 or more, the foaming property tends to be lowered. R3 is a hydrogen atom or a hospital base having 1 to 3 carbon atoms. A hospital having a carbon number of 1 to 3 -13 - 1257425 V. Description of the invention (12) Examples include a methyl group, an ethyl group, and a propyl group. The type of M2, and preferred; ^ is also the same as in the above formula (2). Specific examples of the mercapto-tauryl-type anionic <ionic surfactant represented by the above formula (3) include the following surfactants; sodium lauryl methyl taurate; lauryl methyl taurine Potassium; sodium lauryl sulphonate; sodium methyl taurate; palm sulphate methyl taurine; sodium sulphate methyl taurate; sodium sulphate methyl taurate; Oil fatty acid sodium sulfosyl taurate; coconut oil fatty acid sodium methyl taurate; coconut oil fatty acid 醯 methyl taurine; coconut oil fatty acid 醯 methyl taurate magnesium; coconut oil fatty acid 醯 methyl tauro Acid triethanolammonium; coconut oil fatty acid 醯 methyl taurine and sodium taurate salt; coconut oil fatty acid 醯 methyl taurine and sodium N-methyl taurate; coconut oil fatty acid 醯 methyl tauro Salt of acid and glutamic acid disodium; palm kernel oil fatty acid sodium sulfosyl taurate; palm kernel oil fatty acid 醯 methyl taurine; palm kernel oil fatty acid 醯 methyl taurine lysate; palm kernel Oil fatty acid 醯methyl taurate; salt of palm kernel oil fatty acid 醯 methyl taurine and sodium taurate ; palm kernel oil fatty acid 醯 methyl taurine and sodium N-methyl taurate; palm kernel oil fatty acid 醯 methyl taurine and sodium glycinate; tallow fatty acid 醯 methyl taurate Wait. (undecyl acetoacetate acetate betaine type amphoteric surfactant (b)) b is an undecylenic acid decylamine acetate betaine type amphoteric surfactant, preferably using the following formula (4) The undecylenic acid betaine type amphoteric surfactant is shown. -14· 1257425 V. INSTRUCTIONS (13) R4
I CH尸CH-(CH2)8-C ONH(CH2)mN + -CH2CO〇- (4)I CH Corpse CH-(CH2)8-C ONH(CH2)mN + -CH2CO〇- (4)
Rs 式中，m爲1〜3、較佳爲2〜3之整數，R4及R5分別 獨立表示碳數1〜3個之烷基、或碳數ί〜3個之羥烷基。 較佳之十一碳烯酸醯胺醋酸甜菜鹼型兩性界面活性 齊[J (b)可列舉十一碳烯酸醯胺丙基二甲胺基醋酸甜菜鹼 、十一碳烯酸醯胺乙基二乙胺基醋酸甜菜鹼、十一碳烯 酸醯胺乙基二羥乙胺基醋酸甜菜鹼等。 尙，十一碳烯酸衍生物自以往已知具有高防菌防黴 活性。將十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 使用做爲防菌防黴劑時，以0.5重量％以上爲有效。因 此，含有0.5重量％以上之十一碳烯酸醯胺丙基甜菜鹼 型兩性界面活性劑之本發明之洗淨劑組成物爲防菌防黴 性（殺菌效果）亦爲優良。 (其他之添加劑） 於本發明之洗淨劑組成物中，視需要，於不損害本 發明效果之程度中，亦可含有a及b以外之界面活性劑 、及其他一般於洗淨劑組成物中所使用之添加劑。 a及b以外之界面活性劑例如包含醯胺醋酸甜菜鹼型 兩性界面活性劑。此類醯胺醋酸甜菜鹼型兩性界面活性 劑可列舉辛酸醯胺丙基二甲胺基醋酸甜菜鹼、癸酸醯胺 丙基二甲胺基醋酸甜菜鹼、月桂酸醯胺丙基二甲胺基醋 酸甜菜鹼、肉豆蔻酸醯胺丙基二甲胺基醋酸甜菜鹼、棕 -15- 1257425 五、發明説明（14) 欄酸醯胺丙基二甲胺基醋酸甜菜鹼、硬脂酸醯胺丙基二 甲胺基醋酸甜菜鹼、油酸醯胺丙基二甲胺基醋酸甜菜鹼 、山嵛酸醯胺丙基二甲胺基醋酸甜菜鹼、椰子油脂肪酸 醯胺丙基二甲胺基醋酸甜菜鹼、棕櫚彳;：油脂肪酸醯胺丙 基二甲胺基醋酸甜菜鹼、向日葵油脂肪酸醯胺丙基二甲 胺基醋酸甜菜鹼、硬化牛脂脂肪酸醯胺丙基二甲胺基醋 酸甜菜鹼、月桂酸醯胺乙基二乙胺基醋酸甜菜鹼、肉豆 蔻酸醯胺乙基二乙胺基醋酸甜菜鹼'椰子油脂肪酸醯胺 乙基二乙胺基醋酸甜菜鹼、棕櫚仁油脂肪酸醯胺乙基二 乙胺基醋酸甜菜鹼、月桂酸醯胺乙基二羥乙胺基醋酸甜 菜鹼、肉豆蔻酸醯胺乙基二羥乙胺基醋酸甜菜鹼、椰子 油脂肪酸醯胺乙基二羥乙胺基醋酸甜菜鹼、棕櫚仁油脂 肪酸醯胺乙基二羥乙胺基醋酸甜菜鹼等。 其他之一般洗淨劑組成物所使用之添加劑可列舉例 如下列成分：鯨鱲醇、硬脂醇等之高級醇類；甘油、乙 二醇、丙二醇、1，3-丁二醇等之多元醇類；角鯊烷、荷 荷葩油、橄欖油、蓖麻油、羊毛脂、卵磷脂等之油分；纖 維素醚型陽離子性高分子化合物、陽離子性聚乙烯吡咯 烷酮衍生物、陽離子性聚丙烯酸衍生物、陽離子性聚醯 胺衍生物、聚氯化二甲基二烯丙基銨、氯化二甲基二烯 丙基銨和丙烯酸醯胺之共聚物、烷基聚乙二胺等之陽離 子性高分子化合物；高聚合甲基聚矽氧烷、二甲基矽氧 烷-甲基（聚氧乙烯）矽氧烷共聚物等之聚矽氧衍生物； 二硬脂酸乙二醇酯、苯乙烯聚合物等之珍珠化劑；5 -甲 -16- 1257425 五、發明説明（15 ) 基-2 =異丙基環己醇、辣椒酊等之補強劑；乙二胺四醋 酸鹽、檸檬酸、氰基三醋酸三鈉等之嵌合劑；二苯酮衍 生物 '苯並：（π坐衍生物等之紫外線吸收劑；色素；香料 等。 (洗淨劑組成物） 本發明之洗淨劑組成物爲含有5〜3 5重量％上述a 1、 a2及a3所組成群中選出至少一種，且含有0.5〜20重 量％ b’ a/b之重量比爲3/4〜10/1爲其特徵，且可含有 水、及視需要’ a及b以外之界面活性劑、及、其他之 添加劑。 經由具有上述a和b之配合比，則可提供即使於油分 存在下亦具有高起泡性、優良之泡質及保存安定性，對 於皮膚之刺激低，且洗淨後之觸感乾爽，且即使頻繁使 用亦少引起皮膚乾燥並可保持皮膚濕潤之洗淨劑組成物。 本發明之洗淨劑組成物較佳使用於洗臉料、沐浴精 、廚房用洗劑、洗髮精等，但以根據各個用途作成以下 說明之特定組成爲更佳。 (洗臉料） 將本發明之洗淨劑組成物作成洗臉料時，較佳以高 級脂肪酸鹽（a 1 )和十一碳烯酸醯胺醋酸甜菜鹼型兩性界 面活性齊fj (b)之組合。al較佳含有15〜35重量％，且以 含有18〜32重量％爲更佳。若小於15重量％，則無法取 得做爲洗臉料之較佳的起泡性、泡質、洗淨力、使用感 、若大於3 5重量％則洗淨過度，洗淨後之皮膚乾燥， -17- 1257425 五、發明説明（16 ) 淸洗後之乾爽感差。 b較佳含有0.5〜10重量。/〇，且以含有2〜8重量°/。爲更 佳。b若小於0.5重量。/。則洗淨後皮膚乾燥，且起泡性 、泡質不夠充分，若大於1 0重量％，則洗淨時感有滑 溜，且淸洗後之乾爽感亦差。 a Ι+b以20〜45重量％爲佳，以25〜40重量％爲更佳。 al/b之重量比爲3/1〜10/1爲佳，以3/1〜7/1爲更佳。若 爲此範圍以外，則洗淨時感到滑溜’淸洗後之乾爽感亦 差，或者具有洗淨後之皮膚易乾燥之傾向，故爲不佳。 (沐浴精） 將本發明之洗淨劑組成物作成沐浴精時，較佳亦以 高級脂肪酸鹽（a 1)和十一碳烯酸醯胺醋酸甜菜鹼型兩性 界面活性劑（b)之組合。此時，al較佳含有5〜35重量％ ，且以含有10〜30重量％爲更佳。若小於5重量％，則 無法取得做爲沐浴精之較佳的起泡性、泡質、洗淨力、 使用感、若大於3 5重量％則洗淨過度，洗淨後之皮膚 乾燥，淸洗後之乾爽感差。 b較佳含有0.5〜10重量％，且以含有2〜12重量％爲 更佳。b若小於0.5重量％則洗淨後皮膚乾燥，且起泡 性、泡質不夠充分，若大於1 5重量％，則洗淨時感有 滑溜，且淸洗後之乾爽感亦差。 a Ι+b以10〜40重量％爲佳，以12〜35重量％爲更佳。 al/b之重量比爲2/1〜10/1爲佳，以2/1〜7/1爲更佳。若 爲此範圍以外，則洗淨時感到滑溜，淸洗後之乾爽感亦 -18- 1257425 五、發明説明（17 ) 差，或者具有洗淨後之皮膚易乾燥之傾向，故爲不佳。 (廚房用洗劑） 將本發明之洗淨劑組成物作成廚房用冼劑時，較佳a 爲醯胺醚硫酸酯型陰離子性界面活性劑（a2)或醯基牛磺 酸酯型陰離子性界面活性劑（a 3 )。a 2或a 3任一者可單 獨使用，或者混合使用。又，亦可使用a2所包含之化 合物混合物，且亦可使用a3所包含之化合物混合物。 a2或a3較佳含有5〜30重量％，且以含有1〇〜25重量 %爲更佳。若小於5重量％則於油分存在下之起泡性降 低，若大於3 0重量％則低溫下之歷時安定性變差。 b較佳含有0.5〜2 0重量％，且以含有1〜1 5重量％爲 更佳。b若小於0.5重量。/。則於油分存在下之起泡性降 低，若大於2 0重量％則高溫下之歷時安定性變差。 a2 + b或a3 + b爲1 0〜45重量％，且，a/b(即，a2或a3 與b之重量比）爲3/4〜8/1爲佳。若爲此範圍以外’貝1! 於油分存在下之起泡性降低，且刺激性變強’歷時安定 性有降低之傾向。 尙，a2 + b或a3+b爲15〜40重量％爲更佳，a/b爲1/1 至5 /1爲更佳。 (洗髮精） 將本發明之洗淨劑組成物使用做爲洗髮精時，a爲醯 胺醚硫酸酯型陰離子性界面活性劑（a2)或醯基牛磺酸酯 型陰離子性界面活性劑（a3)爲佳。a2或a3任一者可單 獨使用，或者混合使用。 -19- 1257425 五、發明説明（18 ) a2或a3較佳含有5〜20重量％，且以含有6〜1 5重量 %爲更佳。若小於5重量％則於油分存在下之起泡性降 低，若大於20重量％則低溫下之歷時安定性變差◦ b較佳含有0.5〜20重量％ ’且以含有1〜1 5重量％爲 更佳◦ b若小於0.5重量％則於油分存在下之起泡性降 低，若大於2 0重量％則高溫下之歷時安定性變差。 a2 + b或a3 + b爲6〜30重量％，且，a/b(即，a2或a3 與b之重量比）爲3/4〜5/1爲佳。若爲此範圍以外’貝[】 於油分存在下之起泡性降低，且刺激性變強’歷時安定 性有降低之傾向。 尙，a2 + b或a3 + b爲8〜20重量％爲更佳，a/b爲1/1 至4/1爲更佳。 (實施例） 以下，根據實施例具體說明本發明’但本發明不能 稱爲被限定於此些實施例。又，將高級脂肪酸鹽（a 1)、 醯胺醚硫酸酯型陰離子性界面活性劑（a2)或醯基牛磺酸 酯型陰離子性界面活性劑（a3)之任一者單稱爲a成分’ 且將十一碳烯酸醯胺醋酸甜菜鹼型兩性界面活性劑（b) 單稱爲b成分。 (實施例1〜1 〇、比較例1〜8) 含有高級脂肪酸鹽之洗淨劑組成物，以表1〜3所示 之組成調製。所得之洗淨劑組成物，對於下列所示之 (1)〜（10)項目，根據各項所記載之試驗化予以評價。 (1)重覆洗淨後之皮膚觸感 -20- 1257425 五 '發明説明（19 ) 以健康皮膚之男女各1 〇人爲評試者，使用洗淨劑組 成物5克將手及前腕洗淨。以2 0分鐘間隔重覆1 0回。 此重覆洗淨持續3日，由最後洗淨開始4 8小時後，自 我評價手及前腕皮膚之乾燥狀態，並g下列基準判定， 求出20人之平均値。 2點：於皮膚未感到與試驗前有變化，或有濕潤感。 1點：於皮膚有若干刺痛感，或有若干乾燥感。 〇點：於皮膚有非常刺痛感，或有非常乾燥感。 將平均値1.5點以上判定爲皮膚乾燥少，且觸感良好。 (2)重覆洗淨後之皮膚水分量 測定做爲皮膚水分量指標的導電度（電傳導度）。同上 述（1 )，於洗淨試驗前，測定評試者20人之前腕內側部 之導電度，且同（1)進行3日重覆洗淨。由最後洗淨開 始48小時後，測定評試者20人之前腕內側部之導電度 ，調查皮膚之乾燥狀態。於溫度20°C之屋中安靜30分 鐘後，使用導電計（SKICON-200、IBS公司製）測定左前 腕內側部之導電度3回，並取其平均値。 洗淨試驗前之20人的導電度爲3 00〜8Ό0μ8範圍內之 値。測定洗淨試驗後之導電度’並根據下式： (洗淨後之導電度-洗淨前之導電度）χ 1 〇〇/洗淨前之導 電度），求出導電度之減少率。根據此減少率，如下判 定，求出20人之平均。 2點：導電度之減少率未滿2 0%。 1點：導電度之減少率20%以上〜未滿40%。 -21- 1257425 五、發明説明（2G ) 〇點：導電度之減少率爲40%以上。 將平均値1. 5點以上爲皮膚水分量之維持上爲有效果， 判定爲良好。 (3) 重覆洗淨後之表皮角質細胞之狀態< 同上述（1)進行3日重覆洗淨後，由最後洗淨開始48 小時後，由評試者20人之前腕內側部以深剝皮法採集 表皮角質細胞。將其貼附於載玻片上，以丙酮除去膠帶 ，並使用艷綠、龍膽紅將細胞染色，作成觀察用試料。 使用光學顯微鏡以80倍之倍率觀察1 0個視野。每1視 野爲由視野之右上方依序調查100個細胞。將形狀爲圓 形或接近矩形之正常細胞、與形狀顯著歪斜且核殘存並 且察見不全角化之細胞予以分開，並將觀察1 000個中 之察見正常細胞之比率以百分率表示。根據此百分率如 下判定求出20人之平均點。 2點：察見正常細胞爲90%以上。 1點：察見正常細胞爲70〜90%。 〇點：察見正常細胞爲未滿70%。 平均點爲1.5以上之情況，於不全角化少且進行老舊角 質層之剝離並維持正常表皮角質細胞之狀態上爲有效果， 判定爲良好。 (4) 皮膚刺激性 根據密合貼布試驗予以評價。即，對於健康皮膚之 男女各10人，使用洗淨劑組成物0.5重量％之水溶液 ，並對上腕部內側進行24小時的密合貼布試驗，並以 -22- 1257425 五、發明説明（21 ) 肉眼判定予以評價。將皮膚完全未察見變化之情況視爲 〇點，皮膚察見若干紅斑之情況視爲1點，皮膚察見明 顯紅斑、浮腫之情況視爲2點並求出2 〇人之平均値’ 並以下列三階段進行評價。 < 皮膚刺激性弱（平均値未滿0.5點）。 皮膚刺激性爲中程度（平均値0.5點以上且未滿1.0 點）。 皮膚刺激性強（平均値1 ·〇點以上）。 (5) 起泡力 於岩谷產業（株）製MIRUSER(型號IFM-100)之杯中’ 將組成物以人工硬水（以碳酸耗換算爲1 0 0 P P m以氯化 鈣和離子交換水調製）稀釋成洗淨劑組成物濃度爲1重 量°/。之試驗液5 0克裝入’並於其中添加人工污垢（組成 ··橄欖油5 0重量％、油酸2 0重量％、羊毛脂1 0重量％ 、流動石蠟1 〇重量％、角鯊烯1 0重量％)0 ·3克並將杯 加蓋，於4 0 °C靜置1小時。1小時後’將杯安裝至 MIRUSER，以300 0rpm攪拌5秒鐘，測定攪拌停止1 分鐘後之泡沫高度。將杯之最低位置開始至泡沫高度爲 7公分以上之組成物評價爲起泡力高之組成物。 (6) 泡沫之持續力 對於上述（5)測定攪拌停止5分鐘後之泡沫高度’並 由下式求出。將數値爲90%以上之洗淨劑組成物判定爲 泡沫持續力爲高。 持續率（％) = { (5分鐘後之泡沫高度）/(1分鐘後之泡沬 -23- 1257425 五、發明説明（22 ) 高度）}χΐ〇〇 (7) 泡質 ^ 以男女各1 0人爲評試者，使用洗淨劑組成物5克， 對於手及前腕洗淨時之泡質，如下述定，並求出20 人之平均値。 2點：泡沫細且有彈性力。 1點：泡沬稍粗。 〇點：泡沬粗且缺乏彈力性。 將平均値1.5點以上判定爲洗淨時之泡質爲良好的洗淨 劑組成物。 (8) 洗淨時之滑溜感 以男女各1 0人爲評試者，使用洗淨劑組成物5克， 對於手及前腕洗淨時之泡質，如下述判定，並求出20 人之平均値。 2點：未感到滑溜感之情況。 1點：感到若干滑溜感之情況。 〇點：感到非常滑溜感之情況。 將平均値1.5點以上評價爲洗淨時無滑溜感之洗淨劑組 成物。 (9) 淸洗後之乾爽感 以男女各1 0人爲評試者，使用洗淨劑組成物5克， 對於手及前腕洗淨後之乾爽感，如下述判定，求出20 人之平均値。 2點：感到乾爽感之情況。 -24- 1257425 五、發明説明（23 ) 1點：感到稍微乾爽感之情況。 0點：無感到乾爽感乏情況。 將平均値1.5點以上評價爲洗淨後具有乾爽感之洗淨劑 組成物。 (10)歷時安定性 將洗淨劑組成物於-5 °C保存1個月，觀察其外觀，並 以下列所示之三階段予以評價。 安定性良好（透明溶解或微濁狀，且外觀無變化）° 安定性稍微不良（稍微混濁）。 安定性不良（察見分離、沈澱、或固化）° 結果示於表1〜3。尙，以下所示表中之數字爲表示重 量% 〇 -25- 1257425 五、發明説明（24 ) 表1 實施例（雷量％) 1 2 3 4 5 6 7 钮)月桂酸鉀 10 7 一 4 _ 3 豆蔻酸 __________________________________________________________________ 12 7 - 了— ι 11 2 igl)椰子油脂肪酸三乙醇胺 - - 11 一 15 油酸鉀 - 4 - . 糾)月桂酸和甘胺酸鈉鹽之鹽 - — - 10 2 (al)肉豆#酸和丙胺酸三乙醇胺鹽之釀 - - - 5 ial)月桂酸和麩胺酸鈉之鹽 - - - • _(al)椰子油脂肪酸和離胺酸之鹽 - - - • ⑷)月桂酸和牛磺酸鈉鹽έ鹽 - - - 麵 Φ)十一碳烯酸醯胺丙基二甲胺基醋酸甜菜鹼 5 3 3 8 3 4 ⑼十一碳烯酸醯胺乙基二乙胺基醋酸甜荽鹼 - - - 3 3 al 合if) 22 18 11 6 21 7 20 b合計 5 3 3 6 8 6 4 al/b 4.4 6 3.7 1 2.6 1.2 5 月桂酸醯胺丙基二甲胺基醋酸甜菜輪 - - - 2 —2 椰子油脂肪酸酿胺丙基二甲胺基醋酸甜菜鹼 5 - - 1 5 肉丑鏰_安丙基一甲胺基醋酸甜^ - 4 • 篇 3 月桂酸酿胺乙基二乙胺基醋酸甜菜鹼 - - • 1 標癇酸醯胺丙基二海乙胺基醋酸舌 1¾¾ - 2 • 隹 對羥基苯甲酸甲酯 0.2 0.2 0.2 0.2 0.2 0.2 0.2 丽基苯甲酸丙_ '^ 0.1 0.1 0.1 0.1 0.1 0.1 0.1 香料 — 0.1 0.1 0.1 0.1 0·1 0.1 0.1 精製水 殘餘部分 pH(5 雷量％、25〇C) 9.6 9.5 8.2 9.3 8.5 9.2 8 評價 ⑴重覆洗淨後之舖觸感 腑 谢子 贿 贿 餅 餅 1.9 1.9 1.7 1.8 2 1.9 1.9 (2逋覆洗淨後之皮膚水分量 餅 赌 腑 跑子 嵐子 贿 良好 2 1.9 1.8 2 2 2 18 ⑶重覆洗淨後之表皮角質細臟態 赌 贿 贿 贿 贿 谢子 A 4 KJ 贿 1.8 1.7 1.7 1.8 1.9 1.9 1 9 (4)皮膚刺激性 弱 弱 弱 弱 弱 弱 -——— ii 0 0 0 0 0 〇 (5)起泡力 — 1分鐘之泡沬高度(cm) 局 高 高 高 高 高 w 9.5 9.1 8.3 8.1 9.4 8.9 9 7、 ⑹泡之持繪率 (%) 5分鐘後之泡沬高度(cm) 高 高 局 局 高 高 98.9 97.8 98.8 98.8 98.9 98.9 99^ 9.4 8.9 8.2 8 9.3 ⑺泡質 餅 腑 鮑 赌 赌 贿 1.8 1.7 1.7 1.6 1.9 1.6 ΐψ ⑻洗獅之滑溜感 無 Μ j \\\ Μ j\\\ Μ J k Μ j \ \\ Μ j \\\ 1.8 1.7 1.8 1.6 1.7 1.7 Tr (9)淸洗後之乾爽感 有 有 有 有 有 有 1.9 1.9 2 1.8 2 1.7 ⑽歷時安定性 ~ 〇 〇 〇 〇 〇 1 -26- 1257425 五、發明説明（25 ) 表2 實施1 列(雷量％、 比較例(莆量％) 8 9 10 1 2 3 igli月桂瞻 - 6 8 2 4 豆蔻酸 - 6 12— 1 "3 包Μ子油脂肪酸三乙醇胺 囑 - S------- J W 卿由猶 :―3一— Μ)月桂酸和甘胺酸鈉鹽之鹽 τ『 -" - 包»豆蔻酸和丙胺酸三乙醇胺鹽乏鹽 10 - - 18 桂酸和麩胺酸鈉之鹽 10 - I 〇 Ml 椰子油脂肪酸和離胺酸之鹽 - 7 Ml月桂酸和判黃麵鹽之鹽 - - 汹土r碳烯酸醯胺丙基二甲胺基醋酸菜鹼 c 〇 ~~~—— — _ 8 3 5 (b)十一碳烯酸醯胺乙基二乙胺基醋酸甜菜鹼 - - 2 V/ · Μ合計)_ 30 22 32 3 7 b合ΐί 5 8 6 — 3 〇 ς J 〇 5 al/b 6 2.75 5.3 1 14 7.6 月桂酸醯胺丙某二甲胺基醋酸甜菜鹼 2 椰子油脂肪酸醯胺丙基二甲胺基醋酸甜菜鹼 5 10 - 〇 mJ 5 肉豆蔻酸_柄某一甲胺基醋麵菜鹼 - - 6 月桂酸_胺乙某二乙胺基醋酸甜菜鹼 - - - —-— 棕櫚酸醯胺丙某二羥乙胺基醋酸甜菜鹼 - - 2~ —-. 對羥基苯甲酸甲酯 0.2 0.2 0.2 0.2 〇 ο 0 2 對羥基苯甲酸丙酯 0.1 0.1 0.1 ΤΓ 0 1 0 1 香料 0.1 0.1 0.Γ ΤΓ 0 1 0 1 精製水 pH(5 雷量°/〇、25°C) 8.6 9.3 9.4 ΎΓ Q 5 8.3 評價 y · ⑴重覆洗淨後之舖觸感 餅 谢子 跑子 趣 不良 不良 1.8 1.9 1.8 1.8 0.8 0.5 (2湩覆洗淨後之鑛水分量 赌 腑 贿 遊 不良 不良 1.9 2 1.7 1.7 0.9 0.6 (3)重覆洗淨後之表皮角質細胞狀態 腑 m 腑 不良 不良- 1.8 1.9 1.8 1.8 1.1 0.8 (4)舖刺激性 弱 弱 弱 弱 弱 0 0 0 0 0 0 (5)起泡力 高 高 高 高 高 高 1分鐘之泡沬高度(cm) 9.8 10.5 9.5 7.2 7.4 9.4 ⑹泡之持續率 局 高 高 低 低 筒 (%) 5分鐘後之泡沫高度(cm) 98 99 98.9 6.3 6.6 9.3 9.6 10.4 9.4 87.5 89.2 98.9 ⑺泡質 贿 腑 腑 不良 不良 餅 2 2 1.8 0.9 ΤΧ1 1.8 ⑻洗淨時之滑溜感 Μ j \ \\ Μ J V \Ν 並 j\\\ 有 無 1.9 1.7 1.8 1.3 1.7 1.8 (9)淸洗後之乾爽感 有 有 有 Μ j\\\ 有 無 2 1.7 1.8 1.2 1.7 1.2 (10壢時安定性 〇 〇 〇 〇 〇 〇 -27- 1257425 五、發明説明（26 ) 表3 比較例（重量％) 4 5 6 7 8 (al)月桂酸鉀 7 8 - 10 - (al)肉豆蔻酸 - 12 - 12 8 (al)椰子油脂肪酸二乙醇胺 - - 20 - - (al)油酸鉀 3 - - - (al)月桂酸和甘胺酸鈉鹽之鹽 4 - '- - 5 (al)肉豆蔻酸和丙胺酸三乙醇胺鹽之鹽 一 - 18 - - (al)月桂酸和麩胺隞构之鹽 (al)椰子油脂肪酸和離胺酸之鹽 (al)月桂酸和牛擴酸鈉鹽之鹽 - 9 _ - - (b)十一碳烯酸醯胺丙基二甲胺基醋酸甜菜鹼 10 —Ύ— 丁 — —2—— - (b)十一碳烯酸醯胺乙基二乙胺基醋酸甜菜鹼 6 - - - - al合計） 11 32 38 22 13 b合計 16 2 3 2 0 al/b 0.7 16 12.7 11 • 月桂酸醯胺丙基二甲胺基醋酸甜菜鹼 8 2 3 - - 椰子油脂肪酸醯胺丙基二甲胺基醋酸甜菜鹼 - - 2 4 13 肉豆蔻酸醯胺丙基二甲胺基醋酸甜菜鹼 - - - - - 月桂酸安乙基二乙胺基醋酸甜菜鹼 - - - 4 - 棕櫚酸醯胺丙基二羥乙胺基醋酸甜菜鹼 - 2 - - - 對羥基苯甲酸甲酯 0.2 0.2 0.2 0.2 0.2 對羥基苯甲酸丙酯 0.1 0.1 0.1 0.1 0.1 香料 0.1 0.1 0.1 0.1 0.1 精製水 殘 餘部分 ρΗΓ5 雷量％、25°C) 9.3 9.6 8.4 9.7 9.3 評價 ⑴重覆洗淨後之皮膚觸感 谢子 不良 不良 不良 不良 1.8 0.9 0.8 0.8 0.9 (2湩覆洗淨後之皮膚水分量 m 不良 不良 不良 不良 1.7 1 0.5 0.6 0.4 ⑶重覆洗淨後之表皮角質細》態 谢子 不良 不良 不良 不良 1.7 1.2 1 0.9 0.8 (4)麵刺激性 弱 弱 弱 弱 弱 0 0 0 0 0 (5)起泡力 局 局 局 局 筒 1分鐘之泡沬高度(cm) 9.8 9.4 9.6 9.6 9 ⑹泡之持續率 高 局 局 尚 局 (%) 9.5 9.3 9.5 9.4 8.8 5分鐘後之泡沬高度(cm) 96.9 98.9 99 97.9 97.8 ⑺泡質 舰 m 餅 不良 不良 1.7 1.6 1.7 1.4 1.2 ⑻洗满之滑溜感 有 J V \N Μ Μ j \ \\ Μ y\\\ 1.3 1.7 1.6 1.8 1.6 (9)淸洗後之乾爽感 Μ y\\\ 有 Μ j\\\ 有 有 1.1 1.7 1.1 1.7 1.8 (10壢時安定性 〇 〇 〇 〇 〇 -28- 1257425 五、發明説明（27 ) 由表1及表2之實施例1〜1 〇可知’使用本發明成分 之洗淨劑組成物均於重覆洗淨試驗後之皮膚乾燥少，並 且維持皮膚之水分量’又’表皮角質細胞之狀態亦察見 正常。又，皮膚刺激性亦弱。更且，起泡力、泡沬之持 續力、泡質、安定性良好、並且洗淨時之滑溜感少，淸 洗後之乾爽感良好。 尙，使用實施例1、2、7、8、及10之洗淨劑組成物 ，分別以5人之評試者洗臉時’任何組成物均爲起泡良 好，泡質亦佳，亦未感到洗淨時之滑溜感，淸洗後有乾 爽感，所有人幾乎認爲洗淨後皮膚無刺痛感。 又，將實施例3、5、7、及9之洗淨劑組成物作成浴 沐精並分別使用於5人之評試者時，任一洗淨劑均爲良 好起泡，泡質亦佳，亦未感到洗淨時之滑溜感，淸洗後 有乾爽感，所有人幾乎認爲洗淨後皮膚無刺痛感。 另一方面，表2之比較例1〜3及表3之比較例4〜8 並未得到充分之性能。比較例1中因爲a成分爲比本發 明範圍配合更少，故泡沬之持續力、泡質不爲良好，且 洗淨時有滑溜感。比較例2爲a/b之重量比爲14/1，因 大於10/1，故於重覆洗淨試驗後之皮膚乾燥、皮膚水 分量、表皮角質細胞之狀態上具有問題，泡沫之持續力 、泡質亦不爲良好。比較例3中a成分爲配合多於3 5 重量％，相同於重覆洗淨試驗後之皮膚乾燥、皮膚水分 量、表皮角質細胞之狀態上具有問題。比較例4爲a/b 之重量比爲Π/16，因小於3/4，故洗淨時之滑溜感大 -29· 1257425 五、發明説明（28 ) ，淸洗後之乾爽感亦不充分。比較例5及7因a/b之重 量比爲大於1 〇/1，又比較例8爲不含有b成分，故分 別於重覆洗淨試驗後之皮膚乾燥、皮膚水分量、表皮角 質細胞之狀態上具有問題。比較例7淨泡質亦不夠充分 。又，比較例6爲a成分爲超過3 5重量％，因爲a/b之 重量比爲大於1 〇/1，故於重覆洗淨試驗後之皮膚乾燥 、皮膚水分量、表皮角質細胞之狀態上具有問題。 (實施例1 1〜13及比較例9〜12) 調製表4所示之洗淨劑組成物，對於前述評價項目 (1)〜（4)及（8)〜（10)進行評價。又，起泡性（11)爲進行下 述之評價。將其與其他一般之配合處方（比較例9〜12) 比較。 (1 1)起泡性 以男女各1 0人爲評試者，使用洗淨劑組成物5克將 身體洗淨時之起泡性爲如下述判定。求出20人之平均 値，將平均値1 .5點以上評價爲起泡、泡質良好之洗淨 劑組成物。 2點：起泡良好，且感到泡沫細且具有彈力之情況。 1點：起泡不夠充分或感到泡沬爲粗之情況。 〇點：起泡不夠充分且感到泡沫爲粗之情況。 結果示於表4。 -30- 1257425 五、發明説明（29 ) 表4 實施· 列(重量％) 比較例< :重暈％) 11 12 13 9 10 11 12 (al)月桂酸狎 一 _____________—— 7 - - 7 • • - (al)肉豆蔻酸 __________ — 4 - - 4 - - - (al)椰子油脂肪酸三乙醇胺________________————— - 18 - - 10 • - (al)油酸鉀 ___________________________ — 2 - - 2 - • - (al)月桂酸和甘胺酸鈉鹽之鹽_____—______________________」 細 _ 16 - • - (al)肉豆蔻酸和丙胺酸三乙醇胺鹽之鹽 • '2 ... - - —I—— - - (b)十一碳烯酸醯胺丙基二甲胺基醋酸甜菜鹼 4 4 5 - - - 一了一 al合言子） _ — 13 20 16 13 15 0 0 b合計_ — 4 4 5 0 0 0 3 _ al /b 3.3 5 3.2 - - - - 月桂酸醯胺丙基二甲胺基醋酸甜菜鹼 修 4 • - • 6 1 椰子油脂肪酸醯胺 两基二甲胺基醋酸甜菜- 3 - 3 5 4 • - 椰子油脂肪酸甲基牛磺_—__ - 2 • - 2 4 - 椰子油脂肪酸_安心麩胺酸鈉__ - - - - - 6 - 聚氣乙烯(3E0)月桂酸鈉_ - - - 一 - - 10一 單油酸聚氣乙烯山梨糖醇酐(20EO) - - - - 0.5 - - 月桂酸二乙醇醯胺_ 4 - - 4 - - 3 聚乙二醇1540__ - - - 1 - • - 二硬脂酸乙二醇酯 1.8 1.8 - 1.8 1.8 - - 對羥基苯甲酸甲酯_ 0.2 0.2 0.2 0.2 0.2 0.2 0.2 對羥基苯甲酸丙酯_ 0.1 0.1 0.1 0.1 ι〇Χ 0.1 0.1 香料 ______________ 0.1 0.1 0.1 0.1 0.1 0.1 0.1 精製水__.— 殘餘部分 _ ρΗί 雷量％、25T：) 9.5 8.1 8.6 9.4 8.1 6.8 7.2 評價 __ ⑴重覆洗淨後之皮膚觸感 贿 劍子 m 不良 不良 不良 裡 1.8 1.9 2 0.8 0.8 1.3 1 (2逋覆洗淨後之皮膚水分量 赌 良好 贿 不良 不良 不良 孩 1.9 2 1.9 0.7 0.9 1 0.9 (3逋覆洗淨後之表皮角質細獅犬態 谢子 舰 贿 不良 不良 不良 不良 1.9 1.9 1.8 0.5 0.6 0.9 0.5 (4)皮膚刺激性 li 弱 弱 弱 弱 弱 弱 0 0 0 0 0 0 0.1 ⑻洗淨時之滑溜感 Μ j\w Μ > V Μ j\\\ Μ j \ \\ Μ 有 有 1.9 1.7 1.8 1.7 1.6 0.3 0.1 (9備洗後之乾爽感 有 有 有 有 有 Μ j\\\ 並 2 1.9 1.8 1.8 1.5 0.4 0.3 ⑽歷時安定性_ 〇 〇 〇 〇 〇 〇 〇 (11)起泡性 良好 贿 餅 餅 餅 舰 2 1.8 1.8 1.8 1.7 1.6 1.8 由實施例1 1〜1 3可知，使用本發明成分之洗淨劑組 成物均爲重覆洗淨試驗後之皮膚乾燥少，且維持皮膚之 -31- 1257425 五 '發明説明（30 ) 水分量，又，表皮角質細胞之狀態亦察見正常。又，皮 膚刺激性亦小。更且，起泡性，洗淨時和淸洗後之觸感 良好。其可知比不含有b成分之比較例9及1 0、a成分 和b成分均不含有的比較例1 1、及不倉有a成分的比 較例1 2更明顯優良。 (實施例14〜19及比較例13〜25) 使用醯胺醚硫酸酯型陰離子性界面活性劑（a2)做爲a ，調製表5〜6所示之配合組成的試料。對於所得之洗 淨劑組成物起泡力、皮膚刺激性、及經時安定性，將實 施例1〜1 0之條件稍微改變，並且評價。 (1 2)於油分存在下之起泡力 於岩谷產業（株）製MIRUSER(型號IFM-100)之杯中， 將組成物以人工硬水（以碳酸鈣換算爲ΙΟΟρρηι以氯化 鈣和離子交換水調製）稀釋成界面活性劑濃度爲1重量 %之試驗液50克裝入，並於其中添加人工污垢（組成： 橄欖油50重量％、油酸20重量％、羊毛脂1 0重量％、 流動石蠟10重量％、角鯊烯1〇重量％)克並將杯加 蓋，於40 °C靜置1小時。1小時後，將杯安裝至 MIRUSER，以3000rpm攪拌5秒鐘'，測定攪拌停止1 分鐘後之泡沬高度。將杯之最低位置開始至泡沫高度爲 7公分以上之組成物評價爲起泡力高之組成物。 (13)皮膚刺激性 對於具有健康皮膚之男女各1 0名使用界面活性劑濃 度稀釋成〇. 5重量％之水溶液，並於上腕部內側進行2 4 -32- 1257425 五、發明説明（31 ) 小時之密合貼布試驗，且以肉眼判定進行評價。將皮膚 完全未察見變化之情況視爲〇點，皮膚察見若干紅斑之 情況視爲1點，皮膚察見明顯紅斑、浮腫之情況視爲2 點，求出2 0名之平均値，且依下列三<階段予以評價。 皮膚刺激性弱（平均値未滿〇.5點） 皮膚刺激性爲中程度◦(平均値〇.5點以上且未滿1 .〇 點） 皮膚刺激性強。（平均値1 ·〇點以上） (14)歷時安定性 於5 0毫升附蓋之玻璃製螺管中放入洗淨劑組成物4 5 克，並於_ 5 °C保存1 2小時後，於4 5 °C保存1 2小時’ 將其每日重覆1個月。觀察洗淨劑組成物之外觀’並依 下列二階段予以評價。 〇：安定性良好。（1個月外觀無變化） X :安定性不良好。（1個月以內察見分離和沈殿、固 化、或察見顯著著色） 結果示於表5及6 ^ -33- 1257425 五、發明説明（32 ) 表5 配合 實施例 14 15 16 17 18 19 a2 醯胺醚硫酸酯型 陰離子性界面活性劑u 5 -'· - 20 - 20 醯胺醚硫酸酯型 陰離子性界面活性劑2) 細 1 (Γ - - 20 - 醯胺醚硫酸酯型 陰離子性界面活性劑3) - - 15 - - - b 十一碳烯酸醯胺丙基 甜菜鹼型兩性界面活性劑 1 1 2 3 1 0 15 精製水 殘餘部分 合計 5 10 15 20 20 20 b合計 1 1 2 3 10 15 a2/b 5 10 7.5 6.7 2 1.3 評 價 (12)於油分存在下之起泡力 (cm) 局 局 局 局 局 高 8.5 8.1 8.2 8.3 8.7 8.9 (13)皮膚刺激性 弱 弱 弱 弱 弱 弱 0.2 0.2 0.2 0.2 0.3 0.3 (14)歷時安定性 〇 〇 〇 〇 〇 〇 註1):式（2)之R2CO爲椰子油脂肪酸殘基、η爲4、M2 爲納。 2) :式（2)之R2CO爲椰子油脂肪酸殘基、η爲4、Μ2 爲1/2鎂。 3) :式（2)之R2CO爲椰子油脂肪酸殘基、η爲4、Μ2 爲精胺酸。 -34- 1257425 五、發明説明（） un 艺 1 1 Ο 1 o 1 ΓΝ| « ! 1 1 I 1 ί 1 <m ； · i ! 丨口 1 1 〇 〇 〇 Γν| ο 〇 1 ίΤ) τ—Η _ 肅 m 〇 m ο (Ν Ο 〇 X 〇 m 1 1 殘餘部分 ο 1 Ο m Γν| I 1 1 < 〇 ! 〇 ι i o 寸 m 肅 寸 Ο 〇 1 1 1 〇 ^-H 1 〇 Ο 1 岖 m οι ^-Η X 1 ο 1 〇 (Ν Ο 150 (N UO 晰 _ m Ο X 比較例 ΟΝ. 1 1 <Ν 1 1.....Η tn 0.04 岖 寸 Πί^ _ (Ν Ο X ΟΟ 1 ^Τ) Γ<[ 1 Ο ro tn CNl CN r—H 岖 卜 od Ό Ο X 卜 r—Η 1 Ο 1 τ—Η m O <N Os 酿 ΠΚ\» τ-^ Ο 〇 \ο 1 ιη m 1 IT) tn m 0.14 岖 to 00 咖 瞻 m ο X 1 1 m r-H Ο 1 m i i 〇 o <m 00 寸 咖 贿 (Ν Ο 〇 寸 1 m f i 1 in m ^T) m 岖 VO 肅 m ο X m o 1 in 1 < 1 d t—^ 0.33 IT) 酿 贿 (Ν Ο 〇 配合 s #d \ig 到is X3DI m^- sn 經起 tii mm MM m 蘅 iH \ig 到fe Xirn m^-fen %N 瀣#i mm 塵 蘅 iH \in 副fe 餵虼 mm til mm 鹽 Μ 龍 鏗萌 mm 1到 + 月桂基硫酸鈉 聚氧乙烯(2莫耳)月桂醚硫酸鈉鹽 E繼 mm 舀魎 屮旺· W 11 椰子油脂肪酸醯胺乙基羥乙基甘胺酸鈉 精製水 a2合計 b合計 a2/b (12)於油分存在下之起泡力 (cm) (13)皮膚刺激性 (14)歷時安定性 <N cd 紘I® 1257425 五、發明説明（34 ) 註1):式(2)之R2CO爲椰子油脂肪酸殘基、η爲4、M2爲鈉。 2) :式(2)之R2CO爲椰子油脂肪酸殘基、η爲4、Μ2爲1/2鎂。 3) :式(2)之R2CO爲椰子油脂肪酸殘基、η爲4、Μ2爲精胺酸。 由表5及6可知，本發明之實施例14〜19之洗挣劑組成物即使於油分 存在下亦顯示高起泡性’對於皮膚之刺激低’且爲歷時安定性良好之洗 淨劑組成物。 比較例13之洗淨劑組成物爲a成分小於5重量％，a/b小於3/4，故 於油分存在下之起泡性低。 比較例14之洗淨劑組成物雖然a成分及b成分之含有量爲令人滿足 ，但因a/b超過10，故歷時安定性差。 比較例15之洗淨劑組成物因a成分爲小於5重量％，b成分爲小於 0.5重量％，a/b爲超過10，故於油分存在下之起泡性低。 比較例16之洗淨劑組成物因b成分爲超過20重量％，a/b爲小於3/4 ，故歷時安定性差。 比較例Π之洗淨劑組成物因a成分爲小於5重量％，故於油分存在 下之起泡性低。 比較例18之洗淨劑組成物因b成分爲超過20重量％，故皮膚刺激性 強，且歷時安定性差。 比較例19之洗淨劑組成物因b成分爲超過20重量％，a/b爲小於3/4 ，故歷時安定性差。 比較例20之洗淨劑組成物因b成分爲小於0.5重量％，a/b爲超過10 ，故於油分存在下之起泡性低，且歷時安定性差。 比較例21之洗淨劑組成物因使用月桂基硫酸鈉代替a成分、使用椰 子油脂肪酸醯胺丙基二甲胺基醋酸甜菜鹼代替b成分，故雖於油分存在 -36- 1257425 五、發明説明（35 ) 下之起泡性高，但皮膚刺激性強，且歷時安定性差。 比較例22之洗淨劑組成物因使用聚氧乙烯(2莫耳)月桂醚硫酸鈉代胃 a成分，故於油分存在下之起泡性低。 比較例23之洗淨劑組成物因使用椰子油脂肪哮醯胺丙基二甲胺^酉音 酸甜菜鹼代替b成分，故於油分存在下之起泡性低。 比較例24之洗淨劑組成物因使用椰子油脂肪酸醯胺乙基經乙基#月安 酸鈉，故於油分存在下之起泡性低，且歷時安定性差。 比較例25之洗淨劑組成物爲使用聚氧乙烯(2莫耳)月桂醚硫 a成分，且再使用椰子油脂肪酸醯胺丙基二甲胺基醋酸甜菜驗，故於、油 分存在下之起泡性低。 (實施例20) 根據下述所示之配合處方，調製洗臉用組成物。 配合(重量％) (a2)醯胺醚硫酸酯型陰離子性界面活性劑^ 20 (a2)醯胺醚硫酸酯型陰離子性界面活性劑2) 3 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 5 丙二醇 2 二硬脂醚乙二醇 2 橄欖油 0.5 香料 0.3 精製水 殘餘部分 1) :式(2)之R2CO爲椰子油脂肪酸殘基、η爲4、M2爲鉀。 2) :式(2)之R2CO爲棕櫚仁油脂肪酸殘基、η爲3、Μ2爲鈉。 將此洗臉用組成物以實施例14同樣之方法進行評價。但，於(12)油 -37- 1257425 五、發明説明（36 ) 分存在下之起泡力之評價中，使用口紅(組成：蓖麻油75重量％、蓖麻 醇酸鯨蠟酯20重量％、顏料4.7重量％、香料0.3重量％)代替人工污垢 做爲油分。結果示於表7。此洗臉用組成物即使於口紅存在下亦顯示高 起泡性，且對於皮膚之刺激低，且爲歷時安定性声好之洗淨劑組成物。 (實施例21) 根據下述所示之配合處方，調製洗髮精組成物。 配合(重量％) (a2)醯胺醚硫酸酯型陰離子性界面活性劑i) 10 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 5 二硬脂酸乙二醇酯 2 聚氯化二甲基亞甲基哌啶鐵1 2) 0.3 檸檬酸 0.3 香料 0.3 精製水 殘餘部分 -38- 1 :式⑺之R2CO爲棕櫚仁油脂肪酸殘基、η爲3、M2爲N-甲基牛磺酸 鈉。 2 :使用 CALGON CORPORATION 製「MACOAT 100」。 將此洗髮精組成物以實施例14同樣之方法進行評價。但，於(12)油 分存在下之起泡力之評價中，使用高聚合甲基聚矽氧烷(東麗· Dow Comig· Silicon#株)製「Sm00-l，000,000cs」)代替人王污垢做爲油分 。結果示於表7。此洗髮精組成物即使於高聚合甲基聚矽氧烷之存在下 亦顯示高起泡性，對於皮膚之刺激性低，且爲歷時安定性良好之洗淨劑 組成物。 (實施例22) 1257425 五、發明説明（37 ) 根據下述所示之配合處方’調製食用器具用洗'淨齊㈣且成物。 配合(重量％) (a2)醯胺醚硫酸酯型陰離子性界面活性劑^ 20 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性<劑 10 聚乙二醇(平均分子量1000) 3 乙醇 5 精製水 殘餘部分 1):式(2)之R2C〇爲月桂醯基、η爲2、M2爲鈉。 將此食用器具用洗淨劑組成物以實施例14同樣之方法進ΓΪ評價。結 果示於表7 °此食用器具用洗淨劑組成物即使於'油分存在下亦顯示高起 泡性，對於皮膚之刺激低，且爲歷時安定性良好之洗淨劑組成物。 (實施例23) 根據下述所示之配合處方’調製洗手用組成物。 配合(重量％) (a2)醯胺醚硫酸酯型陰離子性界面活性劑^ 12 (a2)醯胺醚硫酸酯型陰離子性界面活性劑2) 3 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 6 甘油 3 二硬脂酸乙二醇酯 2 橄欖油 〇.3 香料 〇·5 精製水 殘餘部分 1) :式(2)之R2C〇爲棕櫚仁油脂肪酸殘基、η爲3、M2爲鈉。 2) :式(2)之R2C〇爲棕櫚仁油脂肪酸殘基、η爲3、Μ2爲1/2鎂。 -39- 1257425 五、發明説明（38 ) 將此洗手用組成物以實施例14同樣之方法進行評價。結果示於表7 。此洗手用組成物即使於油分存在下亦顯示高起泡性，對於皮膚之刺激 低，且爲歷時安定性良好之洗劑組成物。 (實施例24) 、 根據下述所示之配合處方，調製沐浴精組成物。 配合(重量％) (a2)醯胺醚硫酸酯型陰離子性界面活性劑^ 18 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 6 月桂酸二乙醇醯胺酯 3 丙二醇 2 二硬脂酸乙二醇酯 2 角鯊烷 0.3 香料 0.5 精製水 殘餘部分 1):式(2)之R2CO爲椰子油脂肪酸殘基、η爲4、M2爲鈉。 將此沐浴精組成物以實施例14同樣之方法進行評價。結果示於表7 。此沐浴精組成物即使於油分存在下亦顯示高起泡性，對於皮膚之刺激 低，且爲歷時安定性良好之洗劑組成物。 (實施例25) 根據下述所示之配合處方，調製具有淸涼感之透明洗髮精組成物。 配合(重量％) (a2)醯胺醚硫酸酯型陰離子性界面活性劑^ 4 (a2)醯胺醚硫酸酯型陰離子性界面活性劑2) 3 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 5 -40- 1257425 —-— 立、發明説明（） 纖維素醚型陽離子性高分子化合物3) 0.5 5-甲基-2-異丙基環己醇^ 0.4 檸檬酸 0.3 香料 ★ 0.3 精製水 殘餘部分 1) :式(2)之R2CO爲椰子油脂肪酸殘基、η爲4、Μ2爲精胺酸。 2) :式(2)之R2CO爲椰子油脂肪酸殘基、η爲4、Μ2爲牛磺酸鈉。 3) ··使用Diacel化學工業(株)製「JelnerQH300」。 將此洗髮精組成物以實施例14同樣之方法進行評價。但，於(12)油 分存在下之起泡力之評價中，使用高聚合甲基聚矽氧烷(東麗· Dow Cornig · Silicone(株）製「SH200-l，000,000cs」）代替人工污垢做爲油分 。結果示於表7。此洗髮精組成物即使於高聚合甲基聚矽氧烷之存在下 亦顯示高起泡性，對於皮膚之刺激性低，且爲歷時安定性良好之洗淨劑 組成物。 表7 實方彳 _J 20 21 22 23 24 25 a2合計 23 10 20 15 18 7 b合計 5 5 10 6 6 5 a2/b 4.6 2 2 2.5 3 1.4 (12)於油分存在下之起泡力 高 局 局 局 高 筒 評 (cm) 8.6 8.7 8.8 8.6 8.7 8.7 價 (13)皮膚刺激性 弱 弱 弱 弱 弱 弱 0.3 0.2 0.3 0.2 0.2 0.2 (H)歷時安定性 〇 〇 〇 〇 〇 〇 (實施例26〜31、及比較例26〜38) 使用醯基牛磺酸酯型陰離子性界面活性劑(a3)做爲a，調製表8及表9 所示配合組成之洗淨劑組成物，並評價其性能。結果示於表8及表9。 -41- 1257425 五、發明説明（4G ) 表8 實5 _ 26 27 28 29 30 31 (a3) 醯酸酯型陰離子性界面活性劑丨） 5 - - 20 - 20 醯酸酯型陰離子性界面活性劑2) - 10 - - 20 - 醯*«酸酯型陰離子性界面活性劑3) - -. 15 - - ⑻ 十一碳烯酸醯胺丙基甜菜鹼型 兩性界面活性劑 1 1 2 3 10 15 精製水 殘餘部份 a3合計 5 10 15 20 20 20 b合計 1 1 2 3 10 15 a3/b 5 10 7.5 6.7 2 1.3 評 價 (12)於油分存在下之起泡力 (cm) 局 高 高 局 局 尚 9.3 8.9 9 9.1 9.5 9.7 (13)皮膚刺激性 弱 弱 弱 弱 弱 弱 0.2 0.2 0.2 0.2 0.3 0.3 (14)歷時安定性 〇 〇 〇 〇 〇 〇 註1):式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲鈉。 2) :式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲1/2鎂。 3) :式(3)之R20)爲椰子油脂肪酸殘基、R3爲甲基、M2爲牛磺酸鈉。 -42- 1257425In the formula, wherein m is an integer of 1 to 3, preferably 2 to 3, and R4 and R5 each independently represent an alkyl group having 1 to 3 carbon atoms or a hydroxyalkyl group having 3 to 3 carbon atoms. Preferred undecylenoic acid acetamide acetic acid betaine type amphoteric interface activity [J (b) can be cited as decyl decyl propyl dimethylaminoacetate betaine, undecylenyl decyl ethyl Diethylaminoacetate betaine, decylenoate ethyldihydroxyethylamine acetate betaine, and the like. Indole, an undecylenic acid derivative has been known to have high antibacterial and antifungal activity. When the amphoteric propylaminoglycolide type amphoteric surfactant is used as an antibacterial and antifungal agent, it is effective at 0.5% by weight or more. Therefore, the detergent composition of the present invention containing 0.5% by weight or more of the decyl propylaminoglycolide type amphoteric surfactant is excellent in antibacterial and antifungal properties (sterilization effect). (Other Additives) The detergent composition of the present invention may contain a surfactant other than a and b, and other general detergent compositions, as needed, to the extent that the effects of the present invention are not impaired. Additives used in the process. The surfactant other than a and b includes, for example, a guanamine acetate betaine type amphoteric surfactant. Examples of such amidoxime acetate betaine type amphoteric surfactants include decyl propyl dimethyl dimethyl acetate betaine, decyl propyl methamine acetate betaine, decyl propyl melamine laurate Glycine acetate betaine, myristate propylamine dimethylaminoacetate betaine, brown-15-1257425 V. Description of invention (14) glutamine propylamine dimethylaminoacetate betaine, barium stearate Aminopropyldimethylaminoacetate betaine, decyl propyl dimethylaminoacetate betaine acetate, decyl propyl dimethylaminoacetate betaine acetate, coconut fatty acid lysine propyl dimethylamine Betaine acetate, palm quinone; oil fatty acid guanamine propyl dimethylaminoacetate betaine, sunflower oil fatty acid guanamine propyl dimethylamine acetate betaine, hardened tallow fatty acid guanamine propyl dimethylamino acetic acid Betaine, guanamine laurate ethyldiethylaminoacetate betaine, myristyl myristate ethyldiethylamine acetate betaine 'coconut oil fatty acid guanamine ethyldiethylamine acetate betaine, palm kernel oil Fatty acid guanamine ethyldiethylamine acetate betaine, laurel Indole ethyl dihydroxyethylamine acetate betaine, myristyl myristate ethyl dihydroxyethylamine acetate betaine, coconut oil fatty acid guanamine ethyl dihydroxyethylamine acetate betaine, palm kernel oil fatty acid 醯Amine ethyl dihydroxyethylamine acetate betaine and the like. Examples of the additives used in other general detergent compositions include the following components: higher alcohols such as whale sterol and stearyl alcohol; and polyols such as glycerin, ethylene glycol, propylene glycol, and 1,3-butylene glycol. Oils such as squalane, jojoba oil, olive oil, castor oil, lanolin, lecithin; cellulose ether type cationic polymer compound, cationic polyvinylpyrrolidone derivative, cationic polyacrylic acid derivative High cationicity of cationic polyamine derivatives, poly(dimethyl diallyl ammonium chloride), copolymers of dimethyl diallyl ammonium chloride and decylamine acrylate, alkyl polyethylene diamine, etc. Molecular compound; polyoxyl derivative of highly polymerized methyl polyoxyalkylene, dimethyloxane-methyl (polyoxyethylene) alkane copolymer; ethylene glycol distearate, styrene a pearlizing agent for polymers and the like; 5 - A-16 - 1257425 V. Description of the invention (15) Base-2 = a reinforcing agent such as isopropylcyclohexanol or capsicum; ethylenediaminetetraacetate, citric acid, a chimeric agent such as trisodium cyanotriacetate; a benzophenone derivative (a UV absorber such as a π-spot derivative; a dye; a fragrance, etc.) (Detergent composition) The detergent composition of the present invention contains 5 to 35 wt% of the above-mentioned groups a1, a2 and a3. At least one selected from the group consisting of 0.5 to 20% by weight of b' a/b in a weight ratio of 3/4 to 10/1, and may contain water, and a surfactant other than 'a and b, and And other additives. By having the above-mentioned mixing ratio of a and b, it is possible to provide high foaming property, excellent foam quality and preservation stability even in the presence of oil, which is low in irritation to the skin and after washing A detergent composition which is dry to the touch and which causes dry skin and keeps the skin moist even if it is frequently used. The detergent composition of the present invention is preferably used for a face wash, a bath essence, a kitchen lotion, a shampoo Fine, etc., but it is more preferable to make the specific composition described below according to each use. (Washing material) When the detergent composition of the present invention is used as a face wash, it is preferred to use a higher fatty acid salt (a 1 ) and eleven carbon. Bismuth acid acetate betaine type amphoteric interface Preferably, the combination of fj (b) contains 15 to 35 wt%, more preferably 18 to 32 wt%, and if less than 15 wt%, it is not preferable to obtain a foaming property as a cleansing material. , foaming, detergency, feeling of use, if it is more than 35 wt%, the washing is excessive, and the skin after washing is dry, -17-1257425 5. Invention description (16) The dry feeling after washing is poor. Preferably, it contains 0.5 to 10% by weight, more preferably 2 to 8 weight%, more preferably 0.5%, less than 0.5% by weight, and the skin is dry after washing, and the foaming property and the foam quality are insufficient. When it is more than 10% by weight, it is slippery when washed, and the dry feeling after washing is also poor. a Ι+b is preferably 20 to 45 wt%, more preferably 25 to 40 wt%. The weight ratio of al/b is preferably from 3/1 to 10/1, and more preferably from 3/1 to 7/1. If it is outside this range, it feels slippery when it is washed. The dryness after washing is also poor, or the skin after washing is easy to dry, so it is not good. (Bathing essence) When the detergent composition of the present invention is used as a bath essence, it is preferably a combination of a higher fatty acid salt (a 1) and an undecylenic acid phthalamide betaine type amphoteric surfactant (b). . In this case, al preferably contains 5 to 35% by weight, and more preferably 10 to 30% by weight. If it is less than 5% by weight, it is not preferable to obtain foaming property, foaming property, detergency, and feeling of use as a bathing essence, and if it is more than 35 wt%, the washing is excessive, and the skin after washing is dry, 淸The dryness after washing is poor. b preferably contains 0.5 to 10% by weight, and more preferably 2 to 12% by weight. When b is less than 0.5% by weight, the skin is dried after washing, and the foaming property and the foaming property are insufficient. When it is more than 15% by weight, the feeling is slippery when washed, and the dry feeling after washing is also poor. a Ι+b is preferably 10 to 40% by weight, more preferably 12 to 35% by weight. The weight ratio of al/b is preferably 2/1 to 10/1, and more preferably 2/1 to 7/1. If it is outside this range, it feels slippery when washed, and the dry feeling after washing is also -18- 1257425. 5. The invention (17) is poor, or has a tendency to dry the skin after washing, so it is not good. (Kitchen lotion) When the detergent composition of the present invention is used as a kitchen tanning agent, it is preferred that a is a guanamine ether sulfate type anionic surfactant (a2) or a sulfhydryl taurate type anionic property. Surfactant (a 3 ). Any of a 2 or a 3 may be used alone or in combination. Further, a mixture of the compounds contained in a2 may be used, and a mixture of the compounds contained in a3 may also be used. A2 or a3 preferably contains 5 to 30% by weight, and more preferably 1 to 25% by weight. If it is less than 5% by weight, the foaming property in the presence of oil is lowered, and if it is more than 30% by weight, the stability at a low temperature is deteriorated. b preferably contains 0.5 to 20% by weight, and more preferably 1 to 15% by weight. b if less than 0.5 weight. /. The foaming property in the presence of oil is lowered, and if it is more than 20% by weight, the stability over time at a high temperature is deteriorated. A2 + b or a3 + b is 10 0 to 45% by weight, and a/b (i.e., the weight ratio of a2 or a3 to b) is preferably 3/4 to 8/1. If it is outside this range, the foaming property in the presence of oil is lowered, and the irritancy is increased, and the stability tends to decrease. Preferably, a2 + b or a3+b is preferably 15 to 40% by weight, and a/b is preferably 1/1 to 5/1. (Shampoo) When the detergent composition of the present invention is used as a shampoo, a is an anionic surfactant of the indoleamine sulfate type anionic surfactant (a2) or a mercapto taurate type. The agent (a3) is preferred. Any of a2 or a3 can be used alone or in combination. -19- 1257425 V. Description of the Invention (18) a2 or a3 preferably contains 5 to 20% by weight, and more preferably 6 to 15% by weight. If it is less than 5% by weight, the foaming property in the presence of oil is lowered, and if it is more than 20% by weight, the deterioration of the stability at low temperature is preferably 0.5 to 20% by weight and contains 1 to 15% by weight. More preferably, if it is less than 0.5% by weight, the foaming property in the presence of oil is lowered, and if it is more than 20% by weight, the stability over time at a high temperature is deteriorated. A2 + b or a3 + b is 6 to 30% by weight, and a/b (that is, the weight ratio of a2 or a3 to b) is preferably 3/4 to 5/1. If it is outside this range, the foaming property in the presence of oil is lowered, and the irritancy is increased, and the stability tends to decrease. Preferably, a2 + b or a3 + b is more preferably 8 to 20% by weight, and a/b is preferably 1/1 to 4/1. (Embodiment) Hereinafter, the present invention will be specifically described based on examples, but the present invention is not intended to be limited to the embodiments. Further, any of the higher fatty acid salt (a 1), the indoleamine sulfate type anionic surfactant (a2) or the mercapto taurate type anionic surfactant (a3) is simply referred to as a component. And the undecylenic acid decylamine acetate betaine type amphoteric surfactant (b) is simply referred to as the b component. (Examples 1 to 1 and Comparative Examples 1 to 8) A detergent composition containing a higher fatty acid salt was prepared in the compositions shown in Tables 1 to 3. The obtained detergent composition was evaluated for each of the items (1) to (10) shown below based on the test described in each item. (1) Skin touch after repeated washing -20- 1257425 V'Invention Description (19) For each of the men and women with healthy skin, use a detergent composition of 5 grams to wash the hands and the front wrist. net. Repeat 10 times at 20 minute intervals. This repeated washing was continued for 3 days, and after 48 hours from the last washing, the dry state of the hand and the front wrist skin was evaluated, and the following criteria were determined, and the average enthalpy of 20 persons was determined. 2 points: There is no change in the skin before the test, or a moist feeling. 1 point: There are some tingling sensations on the skin, or some dryness. Awkward: Very tingling on the skin, or very dry. An average of 値1.5 points or more was judged to be less dry skin and a good touch. (2) The amount of skin moisture after repeated washing was measured as the conductivity (electrical conductivity) of the skin moisture component. In the same manner as above (1), before the washing test, the conductivity of the inner part of the wrist before the evaluation of 20 people was measured, and the same (1) was repeated for 3 days. 48 hours after the final washing, the conductivity of the inner part of the wrist before the evaluation of 20 people was measured, and the dry state of the skin was examined. After 30 minutes of quiet in a house at a temperature of 20 ° C, the conductivity of the inner side of the left front wrist was measured 3 times using a conductivity meter (SKICON-200, manufactured by IBS), and the average enthalpy was taken. The conductivity of 20 people before the cleaning test was in the range of 300 to 8 Ό 0 μ8. The conductivity after the cleaning test was measured and the rate of decrease in conductivity was determined according to the following formula: (conductivity after washing - conductivity before washing) χ 1 〇〇 / conductivity before washing). Based on this reduction rate, the average of 20 people was determined as follows. 2 points: The decrease rate of conductivity is less than 20%. 1 point: The decrease rate of conductivity is 20% or more ~ less than 40%. -21- 1257425 V. INSTRUCTIONS (2G) Defects: The reduction rate of conductivity is 40% or more. The average 値 1.5 points or more was effective for maintaining the skin moisture content, and it was judged to be good. (3) The state of epidermal keratinocytes after repeated washing < After the above-mentioned (1) was repeatedly washed for 3 days, 48 hours after the last washing, the epidermal keratinocytes were collected by the deep inner skin of the front part of the wrist of 20 persons. This was attached to a glass slide, the tape was removed with acetone, and the cells were stained with brilliant green and gentian red to prepare an observation sample. Ten fields of view were observed at 80 times magnification using an optical microscope. For each field of view, 100 cells were sequentially investigated from the upper right side of the field of view. The normal cells in a circular or nearly rectangular shape were separated from the cells whose shape was significantly skewed and the nucleus remained and the incomplete keratinization was observed, and the ratio of the observed normal cells in 1 000 was expressed as a percentage. Based on this percentage, the average point of 20 people is determined as follows. 2 points: The normal cells are more than 90%. 1 point: The normal cells are 70 to 90%. Awkward: See normal cells as less than 70%. When the average point is 1.5 or more, it is effective in the case where the degree of incomplete keratinization is small and the exfoliation of the old keratin layer is maintained and the normal epidermal keratinocytes are maintained, and it is judged to be good. (4) Skin irritation was evaluated according to the adhesive patch test. That is, for 10 men and women with healthy skin, an aqueous solution of 0.5% by weight of the detergent composition was used, and the inner side of the upper wrist was subjected to a close-fitting test for 24 hours, and -22-1257425. ) It is evaluated by the naked eye. Treating the skin completely undetected as a defect, the skin sees several erythema as 1 point, and the skin sees obvious erythema and edema as 2 points and finds the average of 2 〇' The evaluation was carried out in the following three stages. < Skin irritation is weak (average 値 less than 0.5 points). Skin irritation is moderate (average 値 0.5 points or more and less than 1.0 points). Skin irritation is strong (average 値1 · 〇 above). (5) The foaming power is in the cup of MIRUSER (model IFM-100) manufactured by Iwatani Co., Ltd.' The composition is made of artificial hard water (calculated as calcium carbonate and ion-exchanged water in terms of carbonic acid consumption of 100 ppm). Diluted to a detergent composition concentration of 1 weight ° /. 50 g of the test solution was loaded into 'and artificial soil was added thereto (composition··Oil oil 50% by weight, oleic acid 20% by weight, lanolin 10% by weight, flowing paraffin 1% by weight, squalene) 10% by weight) 0 · 3 g and the cup was capped and allowed to stand at 40 ° C for 1 hour. After 1 hour, the cup was attached to MIRUSER, stirred at 300 rpm for 5 seconds, and the foam height after 1 minute of stirring was stopped. The composition starting from the lowest position of the cup to a foam height of 7 cm or more was evaluated as a composition having a high foaming power. (6) Sustainability of foam The above-mentioned (5) measurement of the foam height after 5 minutes of stirring stop was determined by the following formula. The detergent composition having a number of enthalpies of 90% or more was judged to have a high foam sustainability. Persistence rate (%) = { (foam height after 5 minutes) / (bubble after 1 minute -23 - 1257425 V. Description of invention (22) Height)} χΐ〇〇 (7) Foam ^ for men and women 1 For the 0 person, the detergent composition was 5 g. For the foam of the hand and the front wrist, the following was determined, and the average enthalpy of 20 persons was determined. 2 points: The foam is fine and elastic. 1 point: The bubble is slightly thicker. 〇 Point: The bubble is thick and lacks elasticity. The average 値 1.5 points or more was judged to be a good detergent composition at the time of washing. (8) The slipperiness of the wash is measured by 10 people for each of the men and women, and 5 grams of the detergent composition is used. For the foam of the hand and the front wrist, the following determination is made, and 20 people are determined. Average 値. 2 o'clock: I don't feel slippery. 1 point: I feel a certain amount of slipperiness. Awkward: I feel very slippery. The average 値 1.5 points or more was evaluated as a detergent composition having no slipperiness at the time of washing. (9) The feeling of dryness after washing is 10% for each male and female, and 5 grams of the detergent composition is used. For the dry feeling after washing the hands and the front wrist, the average of 20 people is determined as follows. value. 2 o'clock: I feel a sense of dryness. -24- 1257425 V. INSTRUCTIONS (23) 1 point: A feeling of a little dryness. 0: No feeling of dryness and feeling. The average 値 1.5 points or more was evaluated as a detergent composition having a dry feeling after washing. (10) Durability The detergent composition was stored at -5 ° C for 1 month, and its appearance was observed and evaluated in the following three stages. Good stability (clearly dissolved or slightly turbid, and no change in appearance) ° Stability is slightly poor (slightly turbid). Poor stability (see separation, precipitation, or solidification) ° The results are shown in Tables 1-3.尙, the numbers in the table below are the weight % 〇-25- 1257425 V. Inventive Note (24) Table 1 Example (Ray %) 1 2 3 4 5 6 7 Button) Potassium laurate 10 7 - 4 _ 3 Myristic acid __________________________________________________________________ 12 7 - - ι 11 2 igl) Coconut oil fatty acid triethanolamine - 11-15 potassium oleate - 4 - . Correction lauric acid and sodium sulphate salt - - 10 2 (al) Bean Bean #酸 and alanine triethanolamine salt brewing - - - 5 ial) lauric acid and sodium glutamate salt - - - • _ (al) coconut oil fatty acid and lysine salt - - - • (4)) lauric acid and sodium taurate salt - salt - - - surface Φ) undecylenic acid guanamine propyl dimethylamino acetic acid betaine 5 3 3 8 3 4 (9) undecylenic acid guanamine ethyl Diethylaminoglycidyl acetate - - 3 3 al if) 22 18 11 6 21 7 20 b total 5 3 3 6 8 6 4 al/b 4.4 6 3.7 1 2.6 1.2 5 guanamine propyl laurate Methylaminoacetate beet round - - - 2 - 2 coconut oil fatty acid-doped aminopropyl dimethylaminoacetate betaine 5 - - 1 5 meat ugly _ propyl one Methylaminoglycolic acid ^ - 4 • Part 3 lauric acid acetophene ethyldiethylaminoacetate betaine - - • 1 痫 醯 醯 醯 二 二 二 二 13 13 13 13 13⁄43⁄4 - 2 • 隹 p-hydroxybenzene Methyl formate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 propyl benzoate _ '^ 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 9.6 9.5 8.2 9.3 8.5 9.2 8 Evaluation (1) The feeling of touch after repeated washing 腑 子 贿 贿 1.9 1.9 1.9 1.9 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 Good bribe 2 1.9 1.8 2 2 2 18 (3) Repeated cleansing of the epidermis, horny, dirty, gambling, bribery, bribery, Aegis, A 4 KJ, bribe, 1.8 1.7 1.7 1.8 1.9 1.9 1 9 (4) Skin irritation weak and weak Weak weak--- ii 0 0 0 0 0 〇(5) Foaming force - 1 minute bubble height (cm) High, high, high and high w 9.5 9.1 8.3 8.1 9.4 8.9 9 7. (6) Rate (%) The height of the bubble after 5 minutes (cm) High and high Bureau 98.9 97.8 98.8 98.8 98.9 98.9 99^ 9.4 8. 9 8.2 8 9.3 (7) blister cake 腑 gambling gambling 1.8 1.7 1.7 1.6 1.9 1.6 ΐψ (8) The sleek feeling of washing the lion j \\\ Μ j\\\ Μ J k Μ j \ \\ Μ j \\\ 1.8 1.7 1.8 1.6 1.7 1.7 Tr (9) Dry feeling after washing 1.9 1.9 2 1.8 2 1.7 (10) Durability ~ 〇〇〇〇〇1 -26- 1257425 V. Description of invention (25) Table 2 Implementation 1 column (% of mine, comparative example (% of 莆) 8 9 10 1 2 3 igli laurel - 6 8 2 4 myristic acid - 6 12-1 "3 hazelnut oil fatty acid triethanolamine 嘱- S------- JW 卿由犹: ―3一— Μ) lauric acid and sodium sulphate salt τ『 -" - package»myristic acid and alanine triethanolamine salt salt 10 - 18 Salt of lauric acid and sodium glutamate 10 - I 〇Ml Coconut oil fatty acid and salt of lysine - 7 Ml lauric acid and salt of yellow salt - - r r r 碳 醯 丙基 二甲Aminoacetate c 〇~~~———— _ 8 3 5 (b) Decanoic acid decylamine ethyldiethylaminoacetate betaine - 2 V / · Μ 计 ) _ 30 22 32 3 7 b merge ΐ 5 8 6 — 3 〇ς J 〇5 al/b 6 2.75 5.3 1 14 7.6 lauric acid guanamine dimethyl dimethylaminoacetate betaine 2 coconut oil fatty acid guanamine propyl dimethylamine acetate betaine 5 10 - 〇mJ 5 Myristic acid _ stalk a certain methylamine succinine - 6 lauric acid _ amine ethane diethyl acetoxyacetate betaine - - - - - palmitic acid guanamine propyl hydroxyethyl hydroxyacetate betaine - - 2~ ---. Methylparaben 0.2 0.2 0.2 0.2 〇ο 0 2 Propyl hydroxybenzoate 0.1 0.1 0.1 ΤΓ 0 1 0 1 Perfume 0.1 0.1 0. Γ ΤΓ 0 1 0 1 Refined water pH ( 5 Thunder amount ° / 〇, 25 ° C) 8.6 9.3 9.4 ΎΓ Q 5 8.3 Evaluation y · (1) After the repeated washing, the touch cake, Xiezi Runzi, bad taste 1.8 1.9 1.8 1.8 0.8 0.5 (2湩 wash After the net, the amount of mineral water gambling and bribery is poor. 1.9 2 1.7 1.7 0.9 0.6 (3) Epidermal keratinocyte state after repeated washing 腑m 腑 Bad dysfunction - 1.8 1.9 1.8 1.8 1.1 0.8 (4) Spreading irritating Weakness and Weakness 0 0 0 0 0 0 (5) Foaming force high, high, high and high 1 minute bubble height (cm) 9.8 10.5 9.5 7.2 7 .4 9.4 (6) Sustained rate of foaming High and low cylinders (%) Foam height after 5 minutes (cm) 98 99 98.9 6.3 6.6 9.3 9.6 10.4 9.4 87.5 89.2 98.9 (7) Poor brittle bad cake 2 2 1.8 0.9 ΤΧ1 1.8 (8) Slip feel when washing Μ j \ \\ Μ JV \Ν and j\\\ Yes or no 1.9 1.7 1.8 1.3 1.7 1.8 (9) After washing, there is something dry Μ j\\\ Yes 2 1.7 1.8 1.2 1.7 1.2 (10 坜 stability 〇〇〇〇〇〇-27- 1257425 V. Description of invention (26 ) Table 3 Comparative example (% by weight) 4 5 6 7 8 (al) Potassium laurate 7 8 - 10 - (al) myristic acid - 12 - 12 8 (al) coconut oil fatty acid diethanolamine - 20 - (al) potassium oleate 3 - - - (al) lauric acid and sodium glycinate salt 4 - '- - 5 (al) salt of myristic acid and alanine triethanolamine salt - 18 - - (al) lauric acid and glutamic acid salt (al) coconut oil fatty acid and lysine salt (al) Salt of lauric acid and bovine sodium salt - 9 _ - - (b) decyl decyl dimethyl dimethyl acetonitrile betaine 10 - Ύ - butyl - 2 - - (b) eleven carbon Ethyl amide Aminoacetic acid betaine 6 - - - - al total) 11 32 38 22 13 b total 16 2 3 2 0 al/b 0.7 16 12.7 11 • decyl laurate propyl dimethylaminoacetate betaine 8 2 3 - - Coconut oil fatty acid allylpropyl dimethylaminoacetate betaine - 2 4 13 Myristate decyl propyl dimethylaminoacetate betaine - - - - - lauric acid diethyl acetoacetate Alkali - - - 4 - decyl propyl propyl hydroxyethyl hydroxyacetate betaine - 2 - - methyl p-hydroxybenzoate 0.2 0.2 0.2 0.2 0.2 propyl p-hydroxybenzoate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Residual water remnant ρΗΓ5 yt%, 25°C) 9.3 9.6 8.4 9.7 9.3 Evaluation (1) Skin contact after repeated washing thank you for poor dysfunction 1.8 0.9 0.8 0.8 0.9 (2湩 After washing) Skin moisture m Poor adverse dysfunction 1.7 1 0.5 0.6 0.4 (3) Epidermal keratin after repeated washing "State Xiezi bad and bad dysfunction 1.7 1.2 1 0.9 0.8 (4) Facial irritation weak weak weak 0 0 0 0 0 (5) Foaming force Bureau Bureau Bureau 1 minute bubble Height (cm) 9.8 9.4 9.6 9.6 9 (6) The sustained rate of the bubble is high (%) 9.5 9.3 9.5 9.4 8.8 The height of the bubble after 5 minutes (cm) 96.9 98.9 99 97.9 97.8 (7) Poor quality of the foam ship m cake 1.7 1.6 1.7 1.4 1.2 (8) The slipperiness of washing is JV \N Μ Μ j \ \\ Μ y\\\ 1.3 1.7 1.6 1.8 1.6 (9) Dry feeling after washing y\\\ Μ j\\ \ There are 1.1 1.7 1.1 1.7 1.8 (10 坜 stability 〇〇〇〇〇-28- 1257425 5, invention description (27) From Table 1 and Table 2, Examples 1 to 1 〇 'Use the ingredients of the present invention The detergent composition showed less dry skin after the repeated washing test, and maintained the water content of the skin and the state of the epidermal keratinocytes was also observed to be normal. Also, skin irritation is weak. Further, the foaming power, the sustainability of the foam, the foam quality, and the stability are good, and the slipperiness at the time of washing is small, and the dry feeling after washing is good.尙, using the detergent compositions of Examples 1, 2, 7, 8, and 10, when the face was evaluated by a panel of five people, 'any composition was foamed well, and the foam quality was good, and did not feel The slippery feeling when washing, and the dry feeling after washing, almost everyone thinks that the skin after washing is not tingling. Further, when the detergent compositions of Examples 3, 5, 7, and 9 were used as bathing essence and used in the evaluation of 5 persons, any of the detergents was excellent in foaming, and the foam quality was also good. I also didn't feel the slipperiness when washing, and I felt dry after washing. Everyone almost thought that the skin after washing was not tingling. On the other hand, Comparative Examples 1 to 3 of Table 2 and Comparative Examples 4 to 8 of Table 3 did not obtain sufficient performance. In Comparative Example 1, since the component a was blended in a smaller range than the range of the present invention, the sustainability of the foam and the foam quality were not good, and there was a slippery feeling upon washing. In Comparative Example 2, the weight ratio of a/b was 14/1, and since it was greater than 10/1, there was a problem in the skin drying, skin moisture content, and epidermal keratinocyte state after the repeated washing test, and the sustainability of the foam. The foam quality is not good either. In Comparative Example 3, the component a was blended in an amount of more than 35 % by weight, which was similar to the state of skin dryness, skin moisture content, and epidermal keratinocytes after the repeated washing test. In Comparative Example 4, the weight ratio of a/b was Π/16, and since it was less than 3/4, the slipperiness at the time of washing was large -29·1257425. 5. The invention description (28), the dry feeling after washing was also insufficient. . In Comparative Examples 5 and 7, the weight ratio of a/b was more than 1 〇/1, and Comparative Example 8 was not containing the b component, so the skin was dried, the skin moisture content, and the epidermal keratinocytes were respectively after the repeated washing test. There is a problem with the status. Comparative Example 7 was not sufficiently clean. Further, in Comparative Example 6, the component a was more than 35 wt%, and since the weight ratio of a/b was more than 1 〇/1, the skin was dried, the skin moisture content, and the state of the epidermal keratinocytes after the repeated washing test. There is a problem. (Examples 1 to 13 and Comparative Examples 9 to 12) The detergent compositions shown in Table 4 were prepared, and the evaluation items (1) to (4) and (8) to (10) were evaluated. Further, the foaming property (11) was evaluated as described below. This was compared with other general prescriptions (Comparative Examples 9 to 12). (1 1) Foaming property The foaming property when the body was washed with 5 g of the detergent composition was determined as follows. The average enthalpy of 20 persons was determined, and the average 値1.5 points or more was evaluated as a detergent composition having good foaming and good foam quality. 2 points: The foaming is good, and the foam is fine and elastic. 1 point: The case where the foaming is insufficient or the bubble is thick. 〇 Point: The situation where the foaming is not enough and the foam is thick. The results are shown in Table 4. -30- 1257425 V. INSTRUCTIONS (29) TABLE 4 IMPLEMENTATION · Column (% by weight) Comparative Example < :Heavy%%) 11 12 13 9 10 11 12 (al) lauric acid 狎_____________—— 7 - - 7 • • - (al) myristic acid __________ — 4 - - 4 - - - (al ) Coconut oil fatty acid triethanolamine ________________ ————— - 18 - - 10 • - (al) Potassium oleate ___________________________ — 2 - - 2 - • - (al) Salt of lauric acid and sodium glycinate _ ____—______________________” 细 16 - • - (al) salt of myristic acid and triethanolamine salt of alanine • '2 ... - - -I - - - (b) decyl decyl decanoate Dimethylaminoacetate betaine 4 4 5 - - - one by one ale) _ — 13 20 16 13 15 0 0 b total _ — 4 4 5 0 0 0 3 _ al /b 3.3 5 3.2 - - - - laurate decyl propyl dimethylaminoacetate betaine repair 4 • - • 6 1 coconut oil fatty acid guanamine diyl dimethylamino acetic acid beet - 3 - 3 5 4 • - coconut oil fatty acid methyl tauro _—__ - 2 • - 2 4 - Coconut oil fatty acid_Anxin glutamate __ - - - - - 6 - Polyethylene (3E0) sodium laurate _ - - - One - - 10 monooleic acid Gas ethylene sorbitan (20EO) - - - - 0 .5 - - Diethanolamine laurate _ 4 - - 4 - - 3 Polyethylene glycol 1540__ - - - 1 - • - Ethylene glycol distearate 1.8 1.8 - 1.8 1.8 - - Hydroxybenzoic acid Ester _ 0.2 0.2 0.2 0.2 0.2 0.2 0.2 propyl p-hydroxybenzoate _ 0.1 0.1 0.1 0.1 ι〇Χ 0.1 0.1 Fragrance ______________ 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Refined water __.— Residual _ ρΗί Thunder %, 25T :) 9.5 8.1 8.6 9.4 8.1 6.8 7.2 Evaluation __ (1) Skin touch after repeated washing, bribery sword m bad and bad malnutrition 1.8 1.9 2 0.8 0.8 1.3 1 (2逋The skin moisture content after washing is good Poor bad bad children 1.9 2 1.9 0.7 0.9 1 0.9 (3 逋 洗 之 表 角 角 细 细 谢 谢 舰 舰 舰 舰 舰 舰 舰 舰 舰 1.9 1.9 1.9 1.8 1.8 0.9 0.9 0.5 Weakness and Weakness 0 0 0 0 0 0 0.1 (8) Slip feel when washing Μ j\w Μ > V Μ j\\\ Μ j \ \\ Μ There are 1.9 1.7 1.8 1.7 1.6 0.3 0.1 (9 wash After the dry feeling, there are some Μ j\\\ and 2 1.9 1.8 1.8 1.5 0.4 0.3 (10) diachronic stability _ 〇〇 〇〇〇〇(11) good foaming cake cake 2 1.8 1.8 1.8 1.7 1.6 1.8 It can be seen from Example 1 1~1 3 that the detergent compositions using the components of the present invention are all repeated washing tests. After the skin is less dry, and maintain the skin -31 - 1257425 five 'invented description (30) water content, in addition, the state of the epidermal keratinocytes is also observed normal. Also, the skin is also less irritating. Moreover, the foaming property is good, and the touch feeling after washing and washing is good. It can be seen that the comparative example 1 1 which is not contained in Comparative Examples 9 and 10, the a component and the b component which do not contain the b component, and the comparative example 1 2 which does not contain the component a are more excellent. (Examples 14 to 19 and Comparative Examples 13 to 25) A sample of the composition shown in Tables 5 to 6 was prepared by using a guanamine ether sulfate type anionic surfactant (a2) as a. The conditions of Examples 1 to 10 were slightly changed and evaluated for the foaming power, skin irritation, and stability over time of the resulting detergent composition. (1) The foaming power in the presence of oil is in the cup of MIRUSER (model IFM-100) manufactured by Iwatani Co., Ltd., and the composition is made of artificial hard water (calculated as calcium chloride and ion exchanged with calcium carbonate). Water-diluted) 50 g of test solution diluted to a surfactant concentration of 1% by weight, and artificial soil added thereto (composition: 50% by weight of olive oil, 20% by weight of oleic acid, 10% by weight of lanolin, flowing 10% by weight of paraffin, 1% by weight of squalene, and the cup was capped and allowed to stand at 40 ° C for 1 hour. After 1 hour, the cup was attached to MIRUSER, stirred at 3000 rpm for 5 seconds', and the height of the bubble after 1 minute of stirring was stopped. The composition starting from the lowest position of the cup to a foam height of 7 cm or more was evaluated as a composition having a high foaming power. (13) Skin irritation For each of the men and women with healthy skin, each of the 10 surfactants is diluted with a surfactant concentration of 5% by weight and applied to the inside of the upper wrist. 2 4 -32 - 1257425 V. Description of invention (31) The adhesion test was carried out for an hour and was evaluated by visual judgment. The situation in which the skin is completely undetected is regarded as a defect, and the condition that the skin sees some erythema is regarded as 1 point, and the condition that the skin sees obvious erythema and edema is regarded as 2 points, and the average 値 of 20 is obtained, and According to the following three < Stage to be evaluated. Skin irritation is weak (average 値 not full 〇. 5 points) Skin irritation is moderate to ◦ (average 値〇.5 points or more and less than 1. 〇 points) Skin irritation is strong. (Average 値1 · 〇 above) (14) After the stability of the 50 ml cover glass screw, put the detergent composition of 4 5 grams, and after storage at _ 5 ° C for 12 hours, Store at 4 5 °C for 1 2 hours' and repeat it for 1 month daily. The appearance of the detergent composition was observed' and evaluated in the following two stages. 〇: Good stability. (No change in appearance in 1 month) X : Stability is not good. (Inspection of separation and stagnation, solidification, or observation of significant coloration within 1 month) The results are shown in Tables 5 and 6^-33- 1257425 V. Description of invention (32) Table 5 Coordination with Example 14 15 16 17 18 19 a2 Indole ether sulfate type anionic surfactant u 5 -'· - 20 - 20 indoleamine sulfate type anionic surfactant 2) fine 1 (Γ - - 20 - guanamine ether sulfate type anionic interface Active agent 3) - - 15 - - - b decyl decyl propyl betaine type amphoteric surfactant 1 1 2 3 1 0 15 Total refinery water residue 5 10 15 20 20 20 b total 1 1 2 3 10 15 a2/b 5 10 7.5 6.7 2 1.3 Evaluation (12) Foaming force in the presence of oil (cm) Bureau Bureau 8.5 8.1 8.2 8.3 8.7 8.9 (13) Skin irritation weak and weak Weak 0.2 0.2 0.2 0.2 0.3 0.3 (14) Duration stability Note 1): R2CO of formula (2) is a coconut oil fatty acid residue, η is 4, and M2 is nano. 2): R2CO of the formula (2) is a coconut oil fatty acid residue, η is 4, and Μ2 is 1/2 mg. 3): R2CO of the formula (2) is a coconut oil fatty acid residue, η is 4, and Μ2 is arginine. -34- 1257425 V. INSTRUCTIONS () un ART 1 1 Ο 1 o 1 ΓΝ | « ! 1 1 I 1 ί 1 <m ; · i ! 丨口 1 1 〇〇〇Γν| ο 〇1 ίΤ) τ—Η _ 肃 m 〇m ο (Ν Ο 〇X 〇m 1 1 Residual part ο 1 Ο m Γν| I 1 1 < 〇! 〇ι io 寸 m 寸 Ο 〇 1 1 1 〇^-H 1 〇Ο 1 岖m οι ^-Η X 1 ο 1 〇 (Ν Ο 150 (N UO _ _ Ο X Comparative Example . 1 1 <Ν 1 1.....Η tn 0.04 岖 inch Πί^ _ (Ν Ο X ΟΟ 1 ^Τ) Γ <[ 1 Ο ro tn CNl CN r—H 岖 卜 od Ό Ο X 卜 r—Η 1 Ο 1 τ—Η m O <N Os Brewing ΠΚ\» τ-^ Ο 〇 \ο 1 ιη m 1 IT) tn m 0.14 岖 to 00 Coffee view m ο X 1 1 m r-H Ο 1 m i i 〇 o <m 00 inch coffee bribe (Ν Ο 〇 inch 1 m f i 1 in m ^T) m 岖 VO 肃 m ο X m o 1 in 1 < 1 dt—^ 0.33 IT) Bribery (Ν Ο 〇 with s #d \ig to is X3DI m^- sn via tii mm MM m 蘅iH \ig to fe Xirn m^-fen %N 瀣#i Mm Dust mites iH \in Deputy fe Feed 虼mm til mm Salt Μ Long 铿 Meng mm 1 to + Sodium lauryl sulfate polyoxyethylene (2 mol) Lauryl ether sodium sulfate E followed by mm 舀魉屮 Wang · W 11 Coconut Oil fatty acid guanamine ethyl hydroxyethyl glycinate sodium refined water a2 total b total a2/b (12) foaming power in the presence of oil (cm) (13) skin irritation (14) diachronic stability <N cd 纮I® 1257425 V. Inventive Note (34) Note 1): R2CO of the formula (2) is a coconut oil fatty acid residue, η is 4, and M2 is sodium. 2): R2CO of the formula (2) is a coconut oil fatty acid residue, η is 4, and Μ2 is 1/2 mg. 3): R2CO of the formula (2) is a coconut oil fatty acid residue, η is 4, and Μ2 is arginine. As is apparent from Tables 5 and 6, the detergent composition of Examples 14 to 19 of the present invention exhibits high foaming property, which is low in irritation to the skin even in the presence of oil, and is a detergent composition having good stability over time. Things. The detergent composition of Comparative Example 13 had a component of less than 5% by weight and a/b of less than 3/4, so that the foaming property in the presence of oil was low. In the detergent composition of Comparative Example 14, although the contents of the a component and the b component were satisfactory, since a/b exceeded 10, the stability was poor over time. The detergent composition of Comparative Example 15 had a component of less than 5% by weight, a component b of less than 0.5% by weight, and a/b of more than 10, so that the foaming property in the presence of oil was low. In the detergent composition of Comparative Example 16, since the component b was more than 20% by weight and the a/b was less than 3/4, the stability was poor over time. In the detergent composition of the comparative example, since the component a is less than 5% by weight, the foaming property in the presence of oil is low. In the detergent composition of Comparative Example 18, since the component b was more than 20% by weight, the skin irritation was strong and the stability was poor. In the detergent composition of Comparative Example 19, since the b component was more than 20% by weight and the a/b was less than 3/4, the stability was poor over time. In the detergent composition of Comparative Example 20, since the b component was less than 0.5% by weight and a/b was more than 10, the foaming property in the presence of oil was low, and the stability was poor over time. The detergent composition of Comparative Example 21 was replaced by the use of sodium lauryl sulfate in place of the a component, and the coconut oil fatty acid guanamine propyl dimethylaminoacetate betaine was used instead of the b component, so that the oil was present in -36-1257425. The foaming property under (35) is high, but the skin is highly irritating and has poor stability over time. In the detergent composition of Comparative Example 22, since polyoxyethylene (2 mol) sodium lauryl ether sulfate was used as the stomach a component, the foaming property in the presence of oil was low. The detergent composition of Comparative Example 23 was low in foaming property in the presence of oil because it was replaced with the component b by using coconut oil, fat, serotonin, propyl dimethylamine, and acid betain. The detergent composition of Comparative Example 24 was low in foaming property in the presence of oil, and had poor stability over time due to the use of the coconut oil fatty acid guanamine ethyl group via ethyl # sodium sulphate. The detergent composition of Comparative Example 25 was prepared by using polyoxyethylene (2 mol) lauryl ether sulfur a component, and further using coconut oil fatty acid guanamine propyl dimethylaminoacetate acetic acid beet, so that it was present in the presence of oil. Low foaming. (Example 20) A composition for face washing was prepared according to the formulation described below. Coordination (% by weight) (a2) indoleamine sulfate type anionic surfactant ^ 20 (a2) indoleamine sulfate type anionic surfactant 2) 3 (b) undecylenic acid amidoxime Betaine type amphoteric surfactant 5 Propylene glycol 2 Distearyl ether glycol 2 Olive oil 0.5 Perfume 0.3 Refining water residue 1): R2CO of formula (2) is coconut oil fatty acid residue, η is 4, M2 is potassium . 2): R2CO of the formula (2) is a palm kernel oil fatty acid residue, η is 3, and Μ2 is sodium. The composition for washing the face was evaluated in the same manner as in Example 14. However, in the evaluation of the foaming power in the presence of (12) oil-37-1257425, the invention (36), lipstick was used (composition: 75 wt% of castor oil, 20 wt% of ricinoleate) , 4.7 wt% of pigment, 0.3 wt% of perfume) instead of artificial soil as oil. The results are shown in Table 7. This face-washing composition exhibits high foaming properties even in the presence of lipstick, and is low in irritation to the skin, and is a detergent composition which is stable in sound stability. (Example 21) A shampoo composition was prepared according to the formulation described below. Blend (% by weight) (a2) indoleamine sulfate type anionic surfactant i) 10 (b) undecylenic acid guanamine propyl betaine type amphoteric surfactant 5 ethylene glycol stearate 2 Poly(dimethylmethylene piperidine) 1 2) 0.3 Citrate 0.3 Perfume 0.3 Refining water residue -38-1: R2CO of formula (7) is palm kernel oil fatty acid residue, η is 3, M2 is N - Methyl taurate. 2 : Use "MACOAT 100" by CALGON CORPORATION. This shampoo composition was evaluated in the same manner as in Example 14. However, in the evaluation of the foaming power in the presence of (12) oil, a highly polymerized methyl polyoxyalkylene ("Sm00-l,000,000cs" manufactured by Toray Dow Comig· Silicon # strain) was used instead of the king. Dirt is used as oil. The results are shown in Table 7. This shampoo composition exhibits high foaming properties even in the presence of highly polymerized methyl polyoxyalkylene, is low in irritation to the skin, and is a detergent composition having good stability over time. (Example 22) 1257425 V. Description of the invention (37) According to the formulation described below, the preparation of the edible utensils was washed and cleaned (4). Coordination (% by weight) (a2) indoleamine sulfate type anionic surfactant ^ 20 (b) undecylenic acid allyl propyl betaine type amphoteric interfacial activity <Agent 10 Polyethylene glycol (average molecular weight 1000) 3 Ethanol 5 Purified water Residual part 1): R2C〇 of the formula (2) is a lauryl group, η is 2, and M2 is sodium. The detergent composition of this edible utensil was evaluated in the same manner as in Example 14. The results are shown in Table 7. The composition of the detergent for edible utensils exhibits high foaming properties even in the presence of oil, and is low in irritation to the skin, and is a detergent composition having good stability over time. (Example 23) A hand washing composition was prepared according to the formulation described below. Coordination (% by weight) (a2) indoleamine sulfate type anionic surfactant ^ 12 (a2) indoleamine sulfate type anionic surfactant 2) 3 (b) undecylenic acid amidoxime Betaine-type amphoteric surfactant 6 Glycerin 3 Ethylene glycol distearate 2 Olive oil 〇.3 Spice 〇·5 Refining water residue 1): R2C 式 of formula (2) is a palm kernel oil fatty acid residue, η is 3 and M2 is sodium. 2): R2C of formula (2) is a palm kernel oil fatty acid residue, η is 3, and Μ2 is 1/2 mg. -39- 1257425 V. Description of the Invention (38) This hand washing composition was evaluated in the same manner as in Example 14. The results are shown in Table 7. This hand-washing composition exhibits high foaming properties even in the presence of oil, is low in irritation to the skin, and is a lotion composition having good stability over time. (Example 24) A bath gel composition was prepared according to the formulation described below. Blend (% by weight) (a2) indoleamine sulfate type anionic surfactant ^ 18 (b) undecylenic acid guanamine propyl betaine type amphoteric surfactant 6 lauric acid diethanol decylamine 3 propylene glycol 2 ethylene glycol distearate 2 squalane 0.3 perfume 0.5 purified water residue 1): R2CO of formula (2) is a coconut oil fatty acid residue, η is 4, and M2 is sodium. The shower gel composition was evaluated in the same manner as in Example 14. The results are shown in Table 7. This bath essence composition exhibits high foaming properties even in the presence of oil, is low in irritation to the skin, and is a lotion composition having good stability over time. (Example 25) A transparent shampoo composition having a dull feeling was prepared according to the formulation described below. Blend (% by weight) (a2) indoleamine sulfate type anionic surfactant ^ 4 (a2) indoleamine sulfate type anionic surfactant 2) 3 (b) undecylenic acid allylamyl propyl Betaine-type amphoteric surfactant 5-40- 1257425 —-— Li, invention description () Cellulose ether type cationic polymer compound 3) 0.5 5-methyl-2-isopropylcyclohexanol ^ 0.4 Citric acid 0.3 Spice ★ 0.3 Residual water residue 1): R2CO of formula (2) is a coconut oil fatty acid residue, η is 4, and Μ2 is arginine. 2): R2CO of the formula (2) is a coconut oil fatty acid residue, η is 4, and Μ2 is sodium taurate. 3) · Use "JelnerQH300" manufactured by Diacel Chemical Industry Co., Ltd. This shampoo composition was evaluated in the same manner as in Example 14. However, in the evaluation of the foaming power in the presence of (12) oil, high-polymeric methyl polyoxyalkylene ("SH200-l,000,000cs" manufactured by Toray Cornish Silicone Co., Ltd.) was used instead of artificial soil. As an oil. The results are shown in Table 7. This shampoo composition exhibits high foaming properties even in the presence of highly polymerized methyl polyoxyalkylene, is low in irritation to the skin, and is a detergent composition having good stability over time. Table 7 实方彳_J 20 21 22 23 24 25 a2 total 23 10 20 15 18 7 b total 5 5 10 6 6 5 a2/b 4.6 2 2 2.5 3 1.4 (12) high foaming power in the presence of oil Bureau of Bureau of High School Rating (cm) 8.6 8.7 8.8 8.6 8.7 8.7 Price (13) Skin irritation Weakness Weakness Weakness 0.3 0.2 0.3 0.2 0.2 0.2 (H) Duration stability 〇〇〇〇〇〇 (Example 26 ～31, and Comparative Examples 26 to 38) Using a mercapto tauryl ester type anionic surfactant (a3) as a, the detergent composition of the composition shown in Tables 8 and 9 was prepared and evaluated. performance. The results are shown in Tables 8 and 9. -41- 1257425 V. INSTRUCTIONS (4G) Table 8 实5 _ 26 27 28 29 30 31 (a3) phthalate type anionic surfactant 丨) 5 - - 20 - 20 phthalate type anionic interface activity Agent 2) - 10 - - 20 - 醯*« acid ester type anionic surfactant 3) - -. 15 - - (8) decyl decyl propylamine betaine type amphoteric surfactant 1 1 2 3 10 15 Refining water residual part a3 total 5 10 15 20 20 20 b total 1 1 2 3 10 15 a3/b 5 10 7.5 6.7 2 1.3 Evaluation (12) Foaming force in the presence of oil (cm) Bureau 9.3 8.9 9 9.1 9.5 9.7 (13) Skin irritation weak, weak, weak, weak 0.2 0.2 0.2 0.2 0.3 0.3 (14) diachronic stability Note 1): R2CO of formula (3) is coconut Oil fatty acid residue, R3 is methyl, and M2 is sodium. 2): R2CO of the formula (3) is a coconut oil fatty acid residue, R3 is a methyl group, and M2 is 1/2 mg. 3): R20) of the formula (3) is a coconut oil fatty acid residue, R3 is a methyl group, and M2 is sodium taurate. -42- 1257425
比較例 〇〇 m 1 1 1 o 1 1 CnI 1 I 1 «r^ m 1 Γ·Η 1 1 1 1 殘餘部分 〇 〇 1 * 〇 τ ·Η 〇 〇 〇 m Cn| o r\| ^Τ) 咖 _ m 〇 〇 1 十.. o o o 1 Ο) 咖 ΠΚν> d X m m ο .丨 1 1 1 1 1 1 1 r—Η 1 o to 寸 寸 m 卜 n^> _ CN Ο 〇 1 1 1 1 r—^ 1 ο r—Η 1 r-^ 咖 OR\> ini 猓 _ 寸 ο ΓΝ1 r· i ΠΊ Ο 〇 X X 芝 1 1 ο 1 岖 m m 沄 1 祖 O 1 I CN| o 150 I ^sO 1 1 i <N 1 眶 1 ι-—( (N 0.04 岖 (N oo _ ο X 1 1 (T) (N 1 « 1 Ο m (N (N 1 i 岖 to 'Ο ο X r-^ 1 1 in ό 1 1 1 1—Η in d <N 贿 咖 r—^ Ο 〇 Os ΓνΙ 1 1 m 1 1 I tn m 0.14 岖 m 〇< 咖 咖 m ο X 00 <Ν « 1 m ψ' i 〇 1 1 1 1 m T—^ O o 咖 <Ν Ο 〇 1 tn C^) 1 r—H 1 1 m 1"·" H cn 岖 寸 oo 咖 m ο X (Ν o 1 1 } i 1 1 1 1 d 0.33 IT) vd <Ν Ο 〇 配合 I s #i 到fe Xltn m^- m. ^ w. m (N ±H 副fe Χ3ΙΠ m^-SE 氍賴 酒屮 廿·齷 稍趣 塵 产^S m 蘅 iH \ig 到fc Χ3ΠΙ π^- m. 氍#i m^r ^ W. 塵 繼 麵 鍇徙 mm 氍虼 丨到 + 月桂基硫酸鈉 聚氧乙烯(2莫耳)月桂醚硫酸鈉 E繼 塵賠 漏 mm «裝 rf E- 箧丨1 1椰子油脂肪酸醯胺乙基羥乙基甘胺酸鈉 精製水 I a3合計 b合計 a3/b (12)於油分存在下之起泡力 (cm) (13)皮膚刺激性 1_______ 1(14)歷時安定性 N m 1257425 42 \ 五 '發明説明（） 註1):式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲鈉。 2) :式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲1/2鎂。 3) :式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲牛磺酸鈉。 由表8及表9可知，本發明之實施例26〜31之j先淨劑組成物即使於油 分存在下亦顯示高起泡性，對於皮膚之刺激低’且爲歷時安定性良好之 洗淨劑組成物。 比較例26之洗淨劑組成物因a成分爲小於5重量％ ’ a/b爲小於3/4 ，故於油分存在下之起泡性低。 比較例27之洗淨劑組成物雖a成分及b成分之含量爲滿足，但因a/b 超過10，故歷時安定性差。 比較例28之洗淨劑組成物因a成分爲小於5重量％，b成分小於5重 量％，且a/b超過10，故於油分存在下之起泡性低。 比較例29之洗淨劑組成物因b成分爲超過20重量％，a/b爲小於3/4 ，故歷時安定性差。 比較例30之洗淨劑組成物因a成分爲小於5重量％ ,故於油分存在 下之起泡性低。 比較例31之洗淨劑組成物因b成分爲超過20重量。/。，故皮膚刺激性 強，且歷時安定性差。 比較例32之洗淨劑組成物因b成分爲超過20重量％，a/b爲小於^ 3/4 ，故歷時安定性差。 比較例33之洗淨劑組成物因b成分爲小於0.5 g量％，a/b爲1〇 ，故於油分存在下之起泡性低，歷時安定性差。 比較例34之洗淨劑組成物因使用月桂基硫酸鈉代替a成分、使用挪 子油脂肪酸醯胺丙基二甲胺基醋酸甜菜鹼代替b成分，故雖於^油# -44- 1257425 五、發明説明（43 ) 下之起泡性高，但皮膚刺激性強，歷時安定性差。 比較例35之洗淨劑組成物因使用聚氧乙烯(2莫耳)月桂醚硫酸鈉代替 a成分，故於油分存在下之起泡性低。 比較例36之洗淨劑組成物因使用椰子油脂肪_醯胺丙基二甲胺基醋 酸甜菜鹼代替b成分，故於油分存在下之起泡性低。 比較例37之洗淨劑組成物因使用椰子油脂肪酸醯胺乙基羥乙基甘胺 酸鈉代替b成分，故於油分存在下之起泡性低，歷時安定性差。 比較例38之洗淨劑組成物爲使用聚氧乙烯(2莫耳)月桂醚硫酸鈉代胃 a成分，且再使用椰子油脂肪酸醯胺丙基二甲胺基醋酸甜菜鹼’故 分存在下之起泡性低。 (實施例32) 根據下述所示之配合處方，調製洗臉用組成物。 配合(重量％) (a3)醯基牛磺酸酯型陰離子性界面活性劑b 20 (a3)醯基牛磺酸酯型陰離子性界面活性劑1 2) 3 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 5 丙二醇 二硬脂酸乙二醇酯 2 2 橄欖油 0.5 香料 0.3 精製水 殘餘部分 -45- 1 :式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲鉀。 2 :式(3)之R2CO爲椰子油脂肪酸殘基、R3爲氫原子、M2爲鈉。 3 將此洗臉用組成物以實施例14同樣之方法進行評價。但’於(12)油 1257425 五、發明説明（44 ) 分存在下之起泡力之評價中，使用口紅(組成：蓖麻油75重量％、蓖麻 醇酸鯨蠟酯20重量％、顏料4.7重量％、香料0.3重量％)代替人工污垢 做爲油分。結果示於表10。此洗臉用組成物即使於口紅存在下亦顯示 高起泡性，且對於皮膚之刺激低，且爲歷時安定_良好之冼淨劑組成物。 (實施例33) 根據下述所示之配合處方，調製洗髮精組成物。 配合(重量％) (a3)醯基牛磺酸酯型陰離子性界面活性劑^ 1〇 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 5 二硬脂酸乙二醇酯 2 聚氯化二甲基亞甲基哌啶_ 2) 〇-3 檸檬酸 〇·3 香料 〇·3 精製水 殘餘部分 1) :式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、Μ2爲Ν-甲基牛磺 酸鈉。 2) :使用 CALGON CORPORATION 製「MACOAT 100」。 將此洗髮精組成物以實施例14同樣之方法進行評價。但，於(12)油 分存在下之起泡力之評價中，使用高聚合甲基聚矽氧烷(東麗· Dow Cornig· Silicone(株）製「SmOO-l’OOOJOOcs」）代替人工污垢做爲油分 。結果示於表10。此洗髮精組成物即使於高聚合甲基聚矽氧烷之存在 下亦顯示高起泡性，對於皮膚之刺激性低’且爲歷時安定性良好之洗淨 劑組成物。 (實施例34) -46- 1257425 五、發明説明（45 ) 根據下述所示之配合處方，調製食用器具用洗淨劑組成物 配合(重量％) (a3)醯基牛磺酸酯型陰離子性界面活性劑^ 20 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性^ 1〇 聚乙二醇(平均分子量1000) 3 乙醇 5 精製水 殘餘部分 1):式(3)之R2CO爲月桂醯基、R3爲甲基、M2爲鈉。 將此食用器具用洗淨劑組成物以實施例14同樣之方法進行評價。結 果示於表10。此食用器具用洗淨劑組成物即使於油分存在下亦顯示高 起泡性，對於皮膚之刺激低，且爲歷時安定性良好之洗淨劑組成物。 (實施例35) 根據下述所示之配合處方，調製洗手用組成物。 配合(重量％) (a3)醯基牛磺酸酯型陰離子性界面活性劑^ 12 (a2)醯基牛磺酸酯型陰離子性界面活性劑2) 3 (b)^^一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 6 甘油 3 二硬脂酸乙二醇酯 2 橄欖油 〇·3 香料 〇·5 精製水 殘餘部分 1) :式(3)之R2CO爲棕櫚仁油脂肪酸殘基、R3爲甲基、M2爲鈉。 2) :式(3)之R2CO爲棕櫚仁油脂肪酸殘基、R3爲甲基、M2爲1/2鎂。 -47 - 1257425 五、發明説明（46 ) 將此洗手用組成物以實施例14同樣之方法進行評價。結果示於表10 。此洗手用組成物即使於油分存在下亦顯示高起泡性，對於皮膚之刺激 低，且爲歷時安定性良好之洗劑組成物。 (實施例36) 根據下述所示之配合處方，調製沐浴精組成物。 配合(重量％) (a3)醯基牛磺酸酯型陰離子性界面活性劑^ 18 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 6 月桂酸二乙醇醯胺酯 3 丙二醇 2 二硬脂酸乙二醇酯 2 角鯊烷 0.3 香料 0.5 精製水 殘餘部分 1) ··式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲鈉。 將此沐浴精組成物以實施例14同樣之方法進行評價。結果示於表10 。此沐浴精組成物即使於油分存在下亦顯示高起泡性，對於皮膚之刺激 低，且爲歷時安定性良好之洗劑組成物。 (實施例37) 根據下述所示之配合處方，調製具有淸涼感之透明洗髮精組成物。 配合(重量％) (a3)醯基牛磺酸酯型陰離子性界面活性劑^ 4 (a3)醯基牛磺酸酯型陰離子性界面活性劑2) 3 (b)十一碳烯酸醯胺丙基甜菜鹼型兩性界面活性劑 5 -48- 1257425 五、發明説明（47 ) 纖維素醚型陽離子性高分子化合物3) 0.5 5-甲基-2-異丙基環己醇’ 0.4 檸檬酸 0.3 香料 0.3 精製水 殘餘部分 1) :式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲鈉。 2) :式(3)之R2CO爲椰子油脂肪酸殘基、R3爲甲基、M2爲牛磺酸鈉。 3) :使用Diacel化學工業(株)製「Jelner QH300」。 將此洗髮精組成物以實施例Μ同樣之方法進行評價。但，於(12)油 分存在下之起泡力之評價中，使用高聚合甲基聚矽氧烷(東麗· Dow Cornig· Silicone(株)製「SH200-l，000,000cs」）代替人工污垢做爲油分 。結果示於表10。此洗髮精組成物即使於高聚合甲基聚矽氧烷之存在 下亦顯示高起泡性，對於皮膚之刺激性低，且爲歷時安定性良好之洗淨 劑組成物。 表10 實方ί _ 32 33 34 35 36 37 a3合計 23 10 20 15 18 7 b合計 5 5 10 6 6 5 a3/b 4.6 2 2 2.5 3 1.4 (12)於油分存在下之起泡力 局 高 局 高 高 高 評 (cm) 9.4 9.5 9.6 9.4 9.5 9.5 (13)皮膚刺激性 弱 弱 弱 弱 弱 弱 價 0.3 0.2 0.3 0.2 0.2 0.2 (14)歷時安定性 〇 〇 〇 〇 〇 〇 產業上之可利用性 本發明之洗淨劑組成物因爲即使於油分存在下亦顯示高起泡性，且起 泡、泡質優良，洗淨時和其後之觸感乾爽，且即使頻繁使用亦少引起皮 -49- 1257425 五、發明説明（48 ) 膚之乾燥且保持皮膚濕潤，歷時安定性良好，故可利用於洗臉用組成物 、洗髮精組成物等。又，可利用於預防面皰洗臉用組成物、防頭皮屑洗 髮精、具有殺菌效果之廚房用洗淨劑組成物(食用器具用洗淨劑組成物） 、洗手用組成物等。 -50-Comparative Example 〇〇m 1 1 1 o 1 1 CnI 1 I 1 «r^ m 1 Γ·Η 1 1 1 1 Residual part 〇〇1 * 〇τ ·Η 〇〇〇m Cn| or\| ^Τ) _ m 〇〇1 十.. ooo 1 Ο) 咖ΠΚν> d X mm ο .丨1 1 1 1 1 1 1 r—Η 1 o to inch inch m 卜 n^> _ CN Ο 〇1 1 1 1 r —^ 1 ο r—Η 1 r-^ 咖OR\> ini 猓_ inchο ΓΝ1 r· i ΠΊ Ο 〇 XX 芝 1 1 ο 1 岖mm 沄1 祖O 1 I CN| o 150 I ^sO 1 1 i <N 1 眶1 ι-—( (N 0.04 岖(N oo _ ο X 1 1 (T) (N 1 « 1 Ο m (N (I 1 i 岖to 'Ο ο X r-^ 1 1 in ό 1 1 1 1—Η in d <N bribes r—^ Ο 〇Os ΓνΙ 1 1 m 1 1 I tn m 0.14 岖m 〇< 咖咖m ο X 00 <Ν « 1 m ψ ' i 〇1 1 1 1 m T—^ O o 咖<Ν Ο 〇1 tn C^) 1 r—H 1 1 m 1"·" H cn 岖 inch oo 咖 m ο X (Ν o 1 1 } i 1 1 1 1 d 0.33 IT) vd <Ν Ο 〇 with I s #i to fe Xltn m^- m. ^ w. m (N ±H de fe Χ3ΙΠ m^-SE 屮廿 屮廿 屮廿 屮廿龌Slightly fun dust ^S m 蘅iH \ig to fc Χ3ΠΙ π^- m. 氍#im^r ^ W. Dust submerged migration mm 氍虼丨 to + sodium lauryl sulfate polyoxyethylene (2 moles) sodium lauryl ether sulfate E dust after the leak mm « loaded rf E- 箧丨 1 1 coconut oil fatty acid guanamine ethyl hydroxy Ethylglycolate refined water I a3 total b total a3/b (12) foaming power in the presence of oil (cm) (13) skin irritation 1_______ 1 (14) duration stability N m 1257425 42 \ five 'Inventive Note () Note 1): R2CO of the formula (3) is a coconut oil fatty acid residue, R3 is a methyl group, and M2 is a sodium. 2): R2CO of the formula (3) is a coconut oil fatty acid residue, R3 is a methyl group, and M2 is 1/2 mg. 3): R2CO of the formula (3) is a coconut oil fatty acid residue, R3 is a methyl group, and M2 is sodium taurate. As is apparent from Tables 8 and 9, in the examples 26 to 31 of the present invention, the composition of the first detergent exhibits high foaming property even in the presence of oil, and is low in irritation to the skin, and is cleaned with good stability over time. Agent composition. In the detergent composition of Comparative Example 26, since the component a was less than 5% by weight and the a/b was less than 3/4, the foaming property in the presence of oil was low. In the detergent composition of Comparative Example 27, although the contents of the a component and the b component were satisfied, since a/b exceeded 10, the stability was poor over time. In the detergent composition of Comparative Example 28, the component a was less than 5% by weight, the component b was less than 5% by weight, and a/b exceeded 10, so that the foaming property in the presence of oil was low. In the detergent composition of Comparative Example 29, since the component b was more than 20% by weight and the a/b was less than 3/4, the stability was poor in duration. In the detergent composition of Comparative Example 30, since the component a was less than 5% by weight, the foaming property in the presence of oil was low. The detergent composition of Comparative Example 31 had a component b of more than 20% by weight. /. Therefore, the skin is highly irritating and has poor stability over time. In the detergent composition of Comparative Example 32, since the b component was more than 20% by weight and a/b was less than ^3/4, the stability was poor over time. In the detergent composition of Comparative Example 33, since the b component was less than 0.5 g%, and a/b was 1 Å, the foaming property in the presence of oil was low, and the stability was poor over time. The detergent composition of Comparative Example 34 was replaced with a component by using sodium lauryl sulfate instead of the component b, and the b component was replaced by the sulfonyl fatty acid guanamine propyl dimethylaminoacetate acetate, so that it was in the oil # -44 - 1257425 According to the invention description (43), the foaming property is high, but the skin irritation is strong, and the stability is poor. In the detergent composition of Comparative Example 35, since polyoxyethylene (2 mol) sodium lauryl ether sulfate was used instead of the a component, the foaming property in the presence of oil was low. In the detergent composition of Comparative Example 36, since the coconut oil fat _ amidoxime dimethylaminoacetic acid betaine was used instead of the b component, the foaming property in the presence of oil was low. In the detergent composition of Comparative Example 37, since the coconut oil fatty acid guanamine ethyl hydroxyethylglycolate was used instead of the b component, the foaming property in the presence of oil was low, and the stability was poor. The detergent composition of Comparative Example 38 was prepared by using polyoxyethylene (2 mol) sodium lauryl ether sulfate as a component of stomach a, and then using coconut oil fatty acid lysylpropyl dimethylaminoacetate betaine. The foaming property is low. (Example 32) A composition for face washing was prepared according to the formulation described below. Formulation (% by weight) (a3) mercapto taurate type anionic surfactant b 20 (a3) mercapto taurate type anionic surfactant 1 2) 3 (b) undecylenate Aminopropyl betaine type amphoteric surfactant 5 propylene glycol ethylene glycol distearate 2 2 olive oil 0.5 perfume 0.3 refined water residue -45- 1 : R2CO of formula (3) is coconut oil fatty acid residue, R3 It is methyl and M2 is potassium. 2: R2CO of the formula (3) is a coconut oil fatty acid residue, R3 is a hydrogen atom, and M2 is sodium. 3 This composition for face washing was evaluated in the same manner as in Example 14. However, in the evaluation of the foaming power in the presence of (12) oil 1257425, the invention (44), lipstick was used (composition: 75 wt% of castor oil, 20 wt% of ricinoleate, and pigment 4.7) The weight %, the fragrance 0.3% by weight) was used as the oil instead of the artificial soil. The results are shown in Table 10. This face-washing composition exhibits high foaming property even in the presence of lipstick, and is low in irritation to the skin, and is a composition for a stable period of time. (Example 33) A shampoo composition was prepared according to the formulation described below. Formulation (% by weight) (a3) mercapto taurate type anionic surfactant ^ 1 〇 (b) undecylenic acid guanamine propyl betaine type amphoteric surfactant 5 distearic acid glycol Ester 2 Poly(dimethylmethylene piperidine) _ 2) 〇-3 bismuth citrate·3 Spice 〇·3 Residual part of purified water 1): R2CO of formula (3) is a coconut oil fatty acid residue, R3 is Methyl and hydrazine 2 are sodium Ν-methyl taurate. 2) : Use "MACOAT 100" by CALGON CORPORATION. This shampoo composition was evaluated in the same manner as in Example 14. However, in the evaluation of the foaming power in the presence of (12) oil, high-polymeric methyl polyoxyalkylene ("SmOO-l'OOOJOOcs" manufactured by Toray Dow Cornig Silicone Co., Ltd.) was used instead of artificial soil. For oil. The results are shown in Table 10. This shampoo composition exhibits high foaming properties even in the presence of highly polymerized methyl polyoxyalkylene, and is low in irritation to the skin, and is a detergent composition having good stability over time. (Example 34) -46- 1257425 V. DESCRIPTION OF THE INVENTION (45) According to the formulation shown below, a detergent composition for preparing an edible utensil is blended (% by weight) (a3) a mercapto sulphonate anion Sexual surfactants 20 (b) Amanta propyl phosphamate betaine type interfacial activity ^ 1 〇 polyethylene glycol (average molecular weight 1000) 3 ethanol 5 refined water residue 1): formula (3) R2CO is lauryl sulfhydryl, R3 is methyl, and M2 is sodium. This food appliance composition was evaluated in the same manner as in Example 14 in the same manner as in Example 14. The results are shown in Table 10. The detergent composition for an edible device exhibits high foaming properties even in the presence of oil, is low in irritation to the skin, and is a detergent composition having good stability over time. (Example 35) A hand washing composition was prepared in accordance with the formulation described below. Coordination (% by weight) (a3) mercapto taurate type anionic surfactant ^ 12 (a2) mercapto taurate type anionic surfactant 2) 3 (b) ^ 一 enoate Aminopropyl betaine type amphoteric surfactant 6 glycerol 3 ethylene glycol distearate 2 olive oil 〇 · 3 spices 〇 · 5 refined water residue 1) : formula (3) R2CO is palm kernel oil fatty acid residue The base, R3 is a methyl group, and M2 is a sodium. 2): R2CO of the formula (3) is a palm kernel oil fatty acid residue, R3 is a methyl group, and M2 is 1/2 mg. -47 - 1257425 V. Description of Invention (46) This hand washing composition was evaluated in the same manner as in Example 14. The results are shown in Table 10. This hand-washing composition exhibits high foaming properties even in the presence of oil, is low in irritation to the skin, and is a lotion composition having good stability over time. (Example 36) A bath gel composition was prepared according to the formulation described below. Coordination (% by weight) (a3) mercapto taurate type anionic surfactant ^ 18 (b) undecylenic acid allyl propyl betaine type amphoteric surfactant 6 lauric acid diethanol decylamine 3 Propylene glycol 2 ethylene glycol distearate 2 squalane 0.3 perfume 0.5 purified water residue 1) · R2CO of formula (3) is a coconut oil fatty acid residue, R3 is a methyl group, and M2 is sodium. The shower gel composition was evaluated in the same manner as in Example 14. The results are shown in Table 10. This bath essence composition exhibits high foaming properties even in the presence of oil, is low in irritation to the skin, and is a lotion composition having good stability over time. (Example 37) A transparent shampoo composition having a dull feeling was prepared according to the formulation described below. Coordination (% by weight) (a3) mercapto taurate type anionic surfactant ^ 4 (a3) mercapto taurate type anionic surfactant 2) 3 (b) undecylenic acid decylamine Propyl betaine type amphoteric surfactant 5 - 48 - 1257425 V. Description of invention (47 ) Cellulose ether type cationic polymer compound 3) 0.5 5-methyl-2-isopropylcyclohexanol ' 0.4 citric acid 0.3 Fragrance 0.3 Residual water residue 1): R2CO of formula (3) is a coconut oil fatty acid residue, R3 is a methyl group, and M2 is sodium. 2): R2CO of the formula (3) is a coconut oil fatty acid residue, R3 is a methyl group, and M2 is sodium taurate. 3): "Jelner QH300" manufactured by Diacel Chemical Industry Co., Ltd. is used. This shampoo composition was evaluated in the same manner as in Example 。. However, in the evaluation of the foaming power in the presence of (12) oil, high-polymeric methyl polyoxyalkylene ("SH200-l,000,000cs" manufactured by Toray Dow Cornig Silicone Co., Ltd.) was used instead of artificial soil. As an oil. The results are shown in Table 10. This shampoo composition exhibits high foaming properties even in the presence of highly polymerized methyl polyoxyalkylene, is low in irritation to the skin, and is a detergent composition having good stability over time. Table 10 Real ί _ 32 33 34 35 36 37 a3 total 23 10 20 15 18 7 b total 5 5 10 6 6 5 a3/b 4.6 2 2 2.5 3 1.4 (12) The foaming power is high in the presence of oil Bureau high and high evaluation (cm) 9.4 9.5 9.6 9.4 9.5 9.5 (13) Skin irritation weak, weak, weak and weak 0.3 0.2 0.3 0.2 0.2 0.2 (14) diachronic stability 〇〇〇〇〇〇 industrial availability The detergent composition of the present invention exhibits high foaming property even in the presence of oil, and has excellent foaming and foaming properties, and is dry and smooth after washing, and causes skin even if it is frequently used. 49- 1257425 V. INSTRUCTIONS (48) The skin is dry and keeps the skin moist, and it has good stability over time, so it can be used for makeup components, shampoo compositions, and the like. In addition, it can be used for a composition for preventing blistering, a dandruff-resistant shampoo, a kitchen detergent composition having a bactericidal effect (a detergent composition for edible utensils), a hand washing composition, and the like. -50-