TW546149B - Antibacterial compositions - Google Patents
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- TW546149B TW546149B TW89112408A TW89112408A TW546149B TW 546149 B TW546149 B TW 546149B TW 89112408 A TW89112408 A TW 89112408A TW 89112408 A TW89112408 A TW 89112408A TW 546149 B TW546149 B TW 546149B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/34—Organic compounds containing sulfur
- C11D3/3418—Toluene -, xylene -, cumene -, benzene - or naphthalene sulfonates or sulfates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Detergent Compositions (AREA)
Abstract
Description
546149 A7 五 、發明說明( 相關申請之對 此爲申請中的1999年6月23曰提出申社从呈m击 垒鱼咕 S甲叫的美國專利申讀 案序唬O9/338,654之後續案。 —發日 本發明係、有關-種抗菌組合物,就像個人保養组合物— =具有較佳者抗該力。更特別者,本發㈣有關抗菌 、'且a物其包括多羥基溶劑’增溶劑,一界面活性劑,和一 選用的抗菌劑,其可提供在—分鐘之内實質的,例如大於 99%,對於革蘭氏陽性菌和革蘭氏陰性菌菌數。 發明背景 抗菌性個人保養組合物爲技藝中已知者。特別有用者爲 抗菌性清潔組合物,其典型地爲用來清潔皮膚以殺滅皮膚 表面的細菌和其他微生物,尤其爲使用者的手,胳臂和 臉。 另一類抗菌個人保養組合物爲手部消毒殺菌凝膠。這類 組合物主要爲供醫護人員用來消毒手和手指。手衛生凝膠 爲用來塗在並予以揉搓到手和手指上,然後使本發明組合 物從皮膚蒸發。 抗菌組合物一般爲用來在,例如,保健工業,食品服務 業’肉品加工業,以及個人消費者的私人領域。抗菌組合 物的廣泛使用説明消費者對於控制皮膚表面的細菌群和其 他微生物群所加之重要性。不過,重要點在於抗菌組合物 能使微生物群快速地實質且廣效衰減而沒有伴隨著毒性和 皮膚刺激的問題。 -4 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) --------^--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 -ϋ ϋ ϋ I ϋ 546149 A7 B7 五、發明說明(2 ㈣者’㈣清潔組合物典型地含有在水性載体中的活 性抗界面活性劑,以及各種其他成份,例如,染 料,香料,PH調節劑,增稠劑,皮膚調理劑,等。已有 數種不同類的抗菌劑經用於抗菌清潔劑中。傳統的抗菌劑 包括雙胍(例如,ehlorhexidine二葡萄糖酸鹽),聯苯化合 物,苯甲醇,trihalocarbanilides,季銨化合物,乙氧化酚 和酚頒化&物,例如經南素取代紛化合物,如(亦 即對-氯間_二甲苯驗)和tricl〇san (亦即,2,4,4,三氯_ 2,_ 羥基-二苯醚)。現今以這些抗菌劑爲基的抗菌組合物都展 見出廣範圍抗菌活性,從低到高,決定於要控制的微生物 以及特別的抗菌組合物。 不過大多數商業抗菌組合物一般只提供低度到中度的抗 菌活性。抗菌活性爲經由對抗廣範園的微生物包括革蘭氏 陽性和革蘭氏陰性微生物來評估的。抗菌組合物所提供的 菌群對數衰減,或衰減百分率與抗菌活力有相關聯。對於 一特別的接觸時間,一般從1 5秒到5分鐘而言,3 - 5的對 數衰減値爲最佳者,丨_ 3的對數衰減値爲較佳者,而小於 1的對數衰減値就較不好。因此,高度較佳抗菌組合物係 在短暫的接觸時間内就對廣範園的抗微生物展現出3 - 5的 對數衣減値。 必須注意的爲高度的對數衰減値爲在pH値爲4和9取 得’但能取得彼等對數衰減値至少一部份爲因爲這些相當 極端的p Η値之故。有如此ρ η値的組合物會刺激皮膚和其 他表面,且因此,爲典型地要避免的。用約5至約8,特 -5- 本紙張尺度適用中國國家標準(CNS)A4規格(21〇 X 297公釐) (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製546149 A7 V. Description of the invention (The related application is related to the application. On June 23, 1999, the application filed by Shen She from the US patent application case of “M hitting the barrier fish” is called O9 / 338,654. -Japanese invention, related-an antibacterial composition, just like a personal care composition-= has better resistance to this force. More specifically, this hairpin is related to antibacterial, and a substance which includes a polyhydroxy solvent. A solvent, a surfactant, and an optional antibacterial agent, which can provide substantial, such as greater than 99%, the number of Gram-positive and Gram-negative bacteria within one minute. BACKGROUND OF THE INVENTION Antibacterial individuals Maintenance compositions are known in the art. Particularly useful are antibacterial cleansing compositions, which are typically used to clean the skin to kill bacteria and other microorganisms on the surface of the skin, especially the user's hands, arms and face. Another type of antibacterial personal care composition is hand disinfection gel. This type of composition is mainly used by medical personnel to disinfect hands and fingers. Hand hygiene gel is used to apply and rub on hands and fingers, and then apply The composition of the invention evaporates from the skin. Antibacterial compositions are generally used in, for example, the health care industry, the food service industry, the meat processing industry, and the private sector of individual consumers. The widespread use of antibacterial compositions illustrates the consumer's need for skin control The importance of the surface bacterial flora and other microflora. However, the important point is that the antibacterial composition can quickly and substantially decay the microflora without accompanying the problems of toxicity and skin irritation. -4 This paper is applicable to China National Standard (CNS) A4 Specification (210 X 297 mm) -------- ^ --------- (Please read the notes on the back before filling this page) Intellectual Property Bureau of the Ministry of Economic Affairs Printed by the Employee Consumer Cooperative-ϋ ϋ ϋ I ϋ 546149 A7 B7 V. Description of the invention (2) The cleaning composition typically contains an active anti-surfactant in an aqueous carrier, and various other ingredients, such as dyes, Perfume, pH adjuster, thickener, skin conditioner, etc. Several different types of antibacterial agents have been used in antibacterial cleansers. Traditional antibacterial agents include biguanides (for example, ehlorhe xidine digluconate), biphenyl compounds, benzyl alcohol, trihalocarbanilides, quaternary ammonium compounds, ethoxylated phenols, and phenol compounds, such as sulfanilin-substituted compounds such as Test) and tricloxasan (that is, 2,4,4, trichloro-2, _hydroxy-diphenyl ether). Antibacterial compositions based on these antibacterial agents are now exhibiting a wide range of antibacterial activity, from Low to high, depends on the microorganisms to be controlled and the special antibacterial composition. However, most commercial antibacterial compositions generally provide only low to moderate antibacterial activity. Antibacterial activity is achieved by combating microbes from Guangfanyuan including Gram Positive and Gram-negative microorganisms were evaluated. The logarithmic decay, or percentage attenuation, of the flora provided by the antibacterial composition is associated with antibacterial activity. For a particular contact time, generally from 15 seconds to 5 minutes, the logarithmic attenuation 3 of 3-5 is the best, the logarithmic attenuation of __3 is the better, and the logarithmic attenuation of less than 1 is Worse. Therefore, the highly preferred antibacterial composition exhibits a logarithmic reduction of 3-5 against the antimicrobials of Guangfanyuan within a short contact time. It must be noted that the logarithmic attenuation of the height 値 is obtained at pH 値 4 and 9, but at least part of them can be obtained because of these rather extreme p Η 値. Compositions with such ρ η 値 can irritate the skin and other surfaces and are therefore typically avoided. Use about 5 to about 8, special -5- This paper size applies Chinese National Standard (CNS) A4 specification (21 × X 297 mm) (Please read the precautions on the back before filling this page) Staff of the Intellectual Property Bureau of the Ministry of Economic Affairs Printed by Consumer Cooperatives
訂丨 I I I I---— — — — — — — — —--^----------I 546149 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明(3 別者約6至約8的中性pH値抗菌組合物很難至不可能達到 很鬲的對數衰減値。 例如,W〇_mo所揭示的組合物包括__,界面 活性劑,溶劑,螯合劑,增稠劑,緩衝劑,和水。w〇 98/0111〇係有關經由減少界面活性劑用量來降低皮膚刺激 性。Order 丨 III I ---— — — — — — — — — ^ ------ I 546149 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (3 types It is difficult to achieve a very low logarithmic decay of the antibacterial composition at a neutral pH of about 6 to about 8. For example, the composition disclosed by WO_mo includes __, a surfactant, a solvent, and a chelating agent. , Thickener, buffer, and water. W98 / 0111〇 is related to reducing skin irritation by reducing the amount of surfactant.
Fendler et al.美國專利第5,635,462號揭示出含pcMx和 所選界面活性劑的組合物。其中所揭示的组合物不含有陰 離子界面活性劑和非離子界面活性劑。 WO 97/46218 和 WO 96/06152 揭示的組合物爲以 tdcl〇san ’有機酸或鹽,增溶劑,和藉基溶劑。 EP 0 505 935揭示的組合物含有pC]V[X,組合著非離子和 陰離子界面活性劑,特別爲非離子嵌段共聚物界面活性 劑。 WO 95/32705揭示出一種溫和的界面活性劑組合物,其 可與抗菌化合如triclosan組合。 W0 95/09605揭示出包含陰離子界面活性劑和烷基多糖 嘗界面活性劑的抗菌組合物。 W0 98/55096揭示出抗微生物擦布其具有一多孔片,片 中浸潰含活性抗微生物劑,陰離子界面活性劑,酸,和水 的抗菌組合物,其中該組合物具有約3.0到約6.0之pH 値0 N.A. Allawala et al. J.Amer.Pharm.Assoc. — Sci.Ed.Vol· XLII· No. 5· ρρ· 267-275,(1953)討論活性抗菌劑與界面活 -6 - 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閱讀背面之注意事項再填寫本頁)Fendler et al. U.S. Patent No. 5,635,462 discloses compositions containing pcMx and selected surfactants. The composition disclosed therein does not contain anionic surfactants and non-ionic surfactants. The compositions disclosed in WO 97/46218 and WO 96/06152 are organic acids or salts of tdclosan's, solubilizers, and borrow solvents. EP 0 505 935 discloses a composition containing pC] V [X in combination with a nonionic and anionic surfactant, especially a nonionic block copolymer surfactant. WO 95/32705 discloses a mild surfactant composition which can be combined with antibacterial compounds such as triclosan. WO 95/09605 discloses an antibacterial composition comprising an anionic surfactant and an alkyl polysaccharide surfactant. WO 98/55096 discloses an antimicrobial wipe having a porous sheet impregnated with an antibacterial composition containing an active antimicrobial agent, an anionic surfactant, an acid, and water, wherein the composition has about 3.0 to about PH pH 6.0 NA Allawala et al. J. Amer. Pharm. Assoc. — Sci. Ed. Vol · XLII · No. 5 · ρρ · 267-275, (1953) discusses active antibacterial agents and interfacial activity -6- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page)
546149 經濟部智慧財產局員工消費合作社印製 A7 -----— B7 —_____ 五、發明說明(4 ) 性劑組合後的抗菌活性。 A.G. Mitchell, J. Pharm.Pharmacol. V〇l. 16, pp. 533-537, (1964)揭示含有PCMX和一非離子界面活性劑展現出抗菌 活性的組合物。Mitchell的文章所揭示的組合物必須在至 少47分鐘的接觸時間後才展現出抗菌活性,因此,本發 明組合物並非高度有效力的。 先前揭示皆依賴於組合物中有傳統活性抗菌劑的存在 (例如:紛化合物)但未解決抗菌組合物中何種組合物成 分係興正提供細菌控制者的問題。先前組合物也不能在約 5到約8的中性pH値,尤其爲在約6到約8的pH値時,且 特別爲在沒有活性抗菌劑時,提供有效的,快速的,廣效 型的細菌控制效果。 因爲抗菌劑的性質及界面活性劑對抗菌劑的影響,所以 很難得到有效的抗菌組合物。例如,有幾種傳統活性抗菌 劑’如紛類,在水中的溶解度非常低,例如,tricl〇san在 水中的落解度爲約5到1 〇 ppm (份數每百萬份)。將界面活 性劑加到組合物中能使抗菌劑的溶解度增加。不過,抗菌 劑的落解度增加’及轉而,抗菌劑在組合物中的量也相應 增加,卻不一定使抗菌效力增加。 於不受任何特別理論的限制之下,據推論界面活性劑的 加入會增加抗菌劑的溶解度但也典型地降低抗菌劑的利 用率’因爲界面活性劑在水中會在界面活性劑的高於臨界 膠械粒濃度時形成膠微粒。此臨界膠微粒濃度係依一界面 活性劑至另一界面活性劑而變異。膠微粒的形成爲重要 本紙張尺度適用中國國家標準(CNS)A4規格(21〇 χ 297公釐) (請先閱讀背面之注意事項再填寫本頁)546149 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 -----— B7 —_____ V. Description of the Invention (4) Antibacterial activity after combination of sex agents. A.G. Mitchell, J. Pharm. Pharmacol. Vol. 16, pp. 533-537, (1964) discloses a composition containing PCMX and a nonionic surfactant exhibiting antibacterial activity. The composition disclosed in Mitchell's article must exhibit antibacterial activity after a contact time of at least 47 minutes, and therefore, the composition of the present invention is not highly potent. Previous disclosures have relied on the presence of traditionally active antibacterial agents (eg, compounds) in the composition but have not addressed the question of which composition component of the antibacterial composition is providing a bacterial controller. Previous compositions also failed to provide an effective, fast, broad-acting type at a neutral pH of about 5 to about 8, especially at a pH of about 6 to about 8, and especially in the absence of an active antibacterial agent. Effect of bacterial control. Due to the nature of the antibacterial agent and the effect of the surfactant on the antibacterial agent, it is difficult to obtain an effective antibacterial composition. For example, there are several conventional active antibacterial agents, such as Miscellaneous, which have very low solubility in water. For example, tricolsan has a degree of dissolution in water of about 5 to 10 ppm (parts per million parts). Adding a surfactant to the composition can increase the solubility of the antibacterial agent. However, the increase in the degree of degradation of the antibacterial agent 'and conversely, the amount of the antibacterial agent in the composition also increases correspondingly, which does not necessarily increase the antibacterial efficacy. Without being bound by any particular theory, it is inferred that the addition of a surfactant will increase the solubility of the antibacterial agent but also typically reduces the utilization of the antibacterial agent because the surfactant in water will be above the threshold of the surfactant Colloidal particles are formed at the concentration of colloidal particles. The critical gel particle concentration varies from one surfactant to another. The formation of colloidal particles is important. The paper size applies the Chinese National Standard (CNS) A4 specification (21 × 297 mm) (Please read the precautions on the back before filling this page)
546149 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明(5 ) 的,因爲膠微粒所具有的親脂區能吸引並增溶抗菌劑,因 而使抗菌劑不能馬上與細菌接觸,且由爲不能在短時間 (亦即,一分鐘或更少)内控制細菌。 溶解在界面活性劑膠微粒中的抗菌劑也會,但卻要在相 當長的時間内,控制細菌。抗菌劑,如果自由存在於水溶 液中而不爲界面活性劑膠微粒所束縛(亦即經活化者), 會被細菌的親脂性膜所吸引並很快完成其的功能。如果抗 菌劑爲界面活性劑膠微粒束縛(亦即,未被活化),此抗 菌劑就只能慢慢地發揮效用且不能在對清潔皮膚實用的短 時間内完成其的功能。 此外’溶解在膠微粒中的抗菌劑在沖洗過程中會輕易地 從皮膚上洗掉,而不能沉積在皮膚表面提供殘留抗菌效 益。反而,該抗菌劑會被洗掉並浪費掉。 综上所述’有需要一種抗菌組合物,其能高度有效地在 短時間内對抗廣效型的革蘭氏陽性菌和革蘭氏陰性菌,且 其中该抗菌活性基本上,或唯一地,係歸因於與傳統活性 抗菌劑不同的組合物成分之存在。本發明正爲關於彼等抗 菌組合物。 發明概述 本發明係有關抗菌組合物其能使革蘭氏陽性菌和革蘭氏 陰性菌在短於約一分鐘之内得到實質地衰減。更特別者, 本發明係有關含有一多羥基溶劑,一增溶劑,一界面活性 劑,水,和一選用的活性抗菌劑之抗菌組合物。於較佳實 例中,本發明係有關含有一多羥基溶劑,一增溶劑,一界 -8 - (請先閱讀背面之注咅?事項再填寫本頁)546149 Printed by A7 B7, Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. 5. Description of the Invention (5), because the lipophilic area of the colloidal particles can attract and solubilize the antibacterial agent, so that the antibacterial agent cannot contact the bacteria immediately, and The reason is that bacteria cannot be controlled in a short time (that is, one minute or less). The antibacterial agent dissolved in the surfactant gel particles can also be used, but the bacteria must be controlled for a relatively long time. The antibacterial agent, if it exists freely in the aqueous solution and is not bound by the surfactant gel particles (that is, activated ones), will be attracted by the lipophilic membrane of the bacteria and quickly complete its function. If the antibacterial agent is bound by the surfactant gel particles (that is, not activated), the antibacterial agent can only slowly perform its function and cannot perform its function in a short time practical for cleaning the skin. In addition, the antibacterial agent dissolved in the gel particles can be easily washed off the skin during the rinsing process, and cannot be deposited on the skin surface to provide residual antibacterial benefits. Instead, the antibacterial agent is washed away and wasted. In summary, there is a need for an antibacterial composition that can highly effectively combat broad-spectrum Gram-positive bacteria and Gram-negative bacteria in a short time, and wherein the antibacterial activity is basically, or exclusively, This is due to the presence of composition ingredients that are different from traditional active antibacterial agents. The present invention relates to their antibacterial compositions. SUMMARY OF THE INVENTION The present invention relates to antibacterial compositions which are capable of substantially attenuating Gram-positive and Gram-negative bacteria in less than about one minute. More specifically, the present invention relates to an antibacterial composition containing a polyhydroxy solvent, a solubilizer, a surfactant, water, and an optional active antibacterial agent. In the preferred embodiment, the present invention relates to a solvent containing a polyhydroxyl, a solubilizer, and a boundary -8-(Please read the note on the back? Matters before filling out this page)
546149546149
面活性齋1,7k , i 、、、W 水,和一活性抗菌劑的抗微生物組合物,其中 及抗菌劑在室溫下測定時呈現在至少2 %飽和度之含量。 據此’本發明_方面係提供一種抗菌組合物其包括: ()、’々1重量%到約5 〇重量。/。的一多經基溶劑,· (b )約1重量%到約5 〇重量。/。的一增溶劑; (C )約1重量%到約2 5重量%的一界面活性劑; (d)約0重量%到約5重量%的一抗微生物劑;和 (e )水。 本發明另一方面係提供一種有效的抗菌組合物其不含傳 統活性抗菌劑,如酚,但含有一多羥基溶劑,增溶劑和界 面活性劑作爲組合物成分其能有效並快速地減低菌群。 本發明另一方面係提供一種有效的抗菌組合物含有一多 基醇,增溶劑和陰離子界面活性劑,但其不含傳統活性 抗菌劑。 本發明又一方面係提供一種抗菌組合物其含有一多羥基 么劑,增溶劑,和界面活性劑,其中該增溶劑對該多輕基 溶劑的重量比爲約1:1到約6:1。較佳者約2:1到約4:1,且 孩界面活性劑係選自下列組合之中者:陰離子界面活性 劑’陽離子界面活性劑,非離子性界面活性劑,兩性界面 活性劑和彼等的混合物。 本發明另一方面係提供一種抗菌組合物其含有多羥基溶 劑’一增溶劑,界面活性劑和活性抗微生物劑,其中該活 性抗菌劑在室溫下所測之含量爲至少2 %且較佳者至少 2 5 %飽和。 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閱讀背面之注意事項再填寫本頁} . :線· 經濟部智慧財產局員工消費合作社印製 546149 A7 B7Antimicrobial composition of 1,7k, i,, W, and an active antibacterial agent, wherein the antibacterial agent exhibits a content of at least 2% saturation when measured at room temperature. Accordingly, an aspect of the present invention is to provide an antibacterial composition comprising: (), ′ 1% by weight to about 50% by weight. /. (B) about 1% by weight to about 50% by weight. /. (C) a surfactant from about 1% to about 25% by weight; (d) from about 0% to about 5% by weight of an antimicrobial agent; and (e) water. Another aspect of the present invention is to provide an effective antibacterial composition which does not contain traditional active antibacterial agents, such as phenol, but contains a polyhydroxy solvent, solubilizer and surfactant as ingredients of the composition, which can effectively and quickly reduce the flora . Another aspect of the present invention is to provide an effective antibacterial composition containing a polyhydric alcohol, a solubilizer, and an anionic surfactant, but it does not contain a conventional active antibacterial agent. Another aspect of the present invention is to provide an antibacterial composition comprising a polyhydroxyl agent, a solubilizing agent, and a surfactant, wherein the weight ratio of the solubilizing agent to the light-based solvent is about 1: 1 to about 6: 1. . The preferred is about 2: 1 to about 4: 1, and the surfactant is selected from the group consisting of anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, and other surfactants. And so on. Another aspect of the present invention is to provide an antibacterial composition containing a polyhydroxy solvent, a solubilizer, a surfactant, and an active antimicrobial agent, wherein the content of the active antibacterial agent measured at room temperature is at least 2% and preferably Those are at least 25% saturated. This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the notes on the back before filling out this page}.: Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 B7
經濟部智慧財產局員工消費合作社印製 本發明另一方面係提供一種抗菌 觸後展現出至少爲2的 物/、在30秒的指 破々對革蘭氏刼性菌(亦即金黃色葡萄 求囷(S· aureus))之對數衰減値。 、色葡萄 ,發明之又另—方面係提供一種 的接觸後展現出至少爲 ,、在3 0秒 囷(Εϋ))之對數衰減値。 (Τ Ρ大料 本發明之再-方面係提供一種 價値的對革蘭氏陽Μ i廿# 口奶弁展現出實質 ^ 、 囷和革蘭氏陰性菌的對數衰減値且舉 有約5到約8的ρΙί値。 ^ ^丑举 =明之另一方面係提供消費者產品其係以本發明抗菌 :口馬基且其爲,例如皮膚清潔劑,身 洗劑? 口保養劑,手部消毒殺菌凝膠,消毒二二 水,龍物洗髮精,硬表面消毒殺菌劑等。 = :万面係提供一種減少動物組織,包括人類组 織中革閑氏陽性及/或革蘭氏陰性菌群的方法,其包括妹 由用本發明組合物接觸組織,如眞皮,一充足的時間二 、勺1 5心到5分鐘,使菌群的量減低到一合意的水平。本發 明組合物可能從皮膚上擦拭或沖洗掉,或可留在皮膚上使 組合物中的揮發性成份蒸發掉。 本發明的上述及其他新的方面和優點將在下文較佳實例 的非限制性説明中予以闡明。 例之詳細説明 個人保養品,特別爲含有傳統活性抗菌劑者,係經知悉 有多年者。自從抗菌個人保養品經引入以來,有許多聲^ -10- 本紙張尺度細中國國家標準(CNS)A4規格(210 X 297公爱)Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. Another aspect of the present invention is to provide an antibacterial touch that exhibits at least 2 /. A (S · aureus)) log decay 値. The color grape, another aspect of the invention, is to provide a logarithmic decay of 至少 (Eϋ) at least 30 seconds after exposure. (Τ Ρ aniseed present invention further - provide a monovalent Zhi aspect based on the gram-positive Μ i port # milk Twenty exhibit substantial ^ Bian, granary and Gram-negative bacteria and Zhi logarithmic decrement of about 5 to give ΡΙί 値 of about 8. ^ ^ ugly = on the other hand is to provide consumer products which are based on the antibacterial of the present invention: oral macchi and which are, for example, skin cleansers, body lotions? Mouth care agents, hand disinfection Bactericidal gel, disinfection of two and two water, dragon substance shampoo, hard surface disinfectant and bactericide, etc. =: Wannian provides a method to reduce Gram-positive and / or Gram-negative bacteria in animal tissues, including human tissues A method of swarming, which involves contacting a tissue, such as a peel, with the composition of the present invention for a sufficient period of time, and spooning for 15 to 5 minutes to reduce the amount of bacteria to a desirable level. The composition of the present invention It may be wiped or rinsed from the skin, or it may be left on the skin to evaporate the volatile components in the composition. The above and other new aspects and advantages of the present invention will be described in the non-limiting description of the preferred examples below Clarification. Examples of detailed personal care products, Do not be those who contain traditional active antibacterial agents, those who have been known for many years. Since the introduction of antibacterial personal care products, there have been many ^ -10- This paper is a fine Chinese national standard (CNS) A4 specification (210 X 297) )
546149 經濟部智慧財產局員工消費合作社印製546149 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs
--------1--------- (請先閱讀背面之注意事項再填寫本頁) H Λί < I I I I-------- 1 --------- (Please read the notes on the back before filling this page) H Λί < I I I I
A7 B7 五、發明說明(8 ) 皆認爲彼等產品可提供抗菌性質。不過,一抗菌組合物要 成爲最有效者,其必須在儘可能短的接觸時間内對廣範園 生物提供高的對數衰減値。 如目前經調配者,市售液體抗菌包組合物只能供_很差 至邊際性時間殺減效率,亦即殺菌速率。表丨概述出市售 商品I殺滅效率,其中每種都含有約〇 2重量%到〇 3重量 %的以〇1〇8仙(亦即,一種傳統抗菌劑)。 革蘭氏陽性菌 皇竟至葡萄球菌 1.39 2.20 1.85 :別相關的大腸桿菌。因而,本發明係關於具有:! 廣效型抗菌效能之抗菌组人妝# U異^ 机囷、、且合物,其可由細菌的快i# ^ (亦即即時殺滅)而測定,幻…W _夬速破 俞人 此係不冋於持續殺滅者。 /、先則Λ泛物比較之下,本發 * 眭間轳苗^ 夺贫月抗囷組合物提供優異 時間仅囷效说·本發明知人 Ρ1、人止乂,人 口物的效能係驚人者,因爲,A7 B7 V. Invention Description (8) All of them believe that their products can provide antibacterial properties. However, for an antibacterial composition to be the most effective, it must provide high logarithmic decay to the Guangfanyuan organism in the shortest possible contact time. As currently formulated, commercially available liquid antimicrobial package compositions can only be used to provide poor performance to marginal time killing efficiency, that is, sterilization rate. Table 丨 summarizes the killing efficiency of commercially available products I, each of which contains about 0.02 wt% to 0.33 wt% of 0.018 cents (i.e., a traditional antibacterial agent). Gram-positive bacteria to staphylococcus 1.39 2.20 1.85: Other related E. coli. Therefore, the present invention is related to the antibacterial group human makeup # U 异 ^ 机 囷, and compound which has :! a broad-spectrum antibacterial effect, which can be measured by the bacteria's fast i # ^ (that is, instant killing), magic … W _ 夬 Bao Yuren is not adept at killing continuously. / 、 Comparison of the first Λ general matter, this hair * 眭 轳 轳 ^ Poverty-stricken moon anti-composition composition provides excellent time only effect theory · The present inventor P1, human only, the effectiveness of population is amazing ,because,
良谍JS忐八、’'口物不含活性抗菌劑或本 馬選用成份的活性抗菌劑囷H I 的抗菌效能與多羥基The antibacterial efficacy and polyhydroxy group of the active antibacterial agent 囷 H I, which contains no active antibacterial agent or the horse's optional ingredients.
本紙張尺度適財® x 297公釐) 經濟部智慧財產局員工消費合作社印製 546149 A7 ---------- B7 五、發明說明(9 ) 劑,增溶劑和界面活性劑的存在相關聯。於較佳實例中, 該增溶劑對該多羥基溶劑的重量比爲約1:1至約6:1。在含 有選用活性抗微生物劑的實例中,該藥劑在室溫下測量時 的含量爲至少爲2 %,且較佳者至少爲2 5 %飽和度。 對於選用的活性抗微生物劑的” %飽和度”,經發現一活 性劑的抗微生物效能可與該藥劑接近微生物所含活性部位 的速度相關聯。決定此藥劑輸送到作用部位的速度之驅動 力爲藥劑在作用部位與外界水相之間的化學勢之差異。換 言之,一活性劑的殺微生物活性係與其在外界相中的熱力 學活性成正比。因此,熱力學活性和濃度,皆爲關於抗微 生物效能的重要變數。如在後文要更完全討論者,方便上 白和熱力學活性關聯到活性抗菌劑在組合物連續水相中的 百分飽和度。 一活性抗菌劑在任何組合物,包括含界面活性劑的組合 物,中的百分飽和度在理論上可表爲: % 飽和度=[C/Cs]xl〇〇% 其中C指抗菌劑在組合物中的濃度而Cs指在室溫下抗菌劑 在組合物中的飽和濃度。一經溶解在含界面活性劑組合物 中的抗菌活性劑之百分飽和度,或相對熱力學活性或相對 化學勢,S、组合物内的任何處都爲一樣W。因此抗菌劑” 在組合物",”在組合物的連續水相中”和”在組合物的膠 微粒假相中”的百分飽和度等詞都爲可以互換者,並且在 揭示通篇文章中都如此使用。 s活性抗菌劑在組合物和目標組織之間的熱力學活性差 (請先閱讀背面之注咅?事項再填寫本頁) 訂 線This paper is suitable for scale ® x 297 mm) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 ---------- B7 V. Description of the invention (9) of the agents, solubilizers and surfactants There is an association. In a preferred embodiment, the weight ratio of the solubilizer to the polyhydroxy solvent is from about 1: 1 to about 6: 1. In the case where the active antimicrobial agent is selected, the content of the agent when measured at room temperature is at least 2%, and preferably at least 25% saturation. With regard to the "% saturation" of the active biocide selected, it has been found that the antimicrobial efficacy of an active agent can be related to the speed at which the agent approaches the active site contained in the microorganism. The driving force that determines the speed at which the agent is delivered to the site of action is the difference in chemical potential between the site of action and the external aqueous phase. In other words, the microbicidal activity of an active agent is directly proportional to its thermodynamic activity in the external phase. Therefore, both thermodynamic activity and concentration are important variables regarding antimicrobial activity. As will be discussed more fully later, it is convenient to associate whitening and thermodynamic activity with the percent saturation of the active antibacterial agent in the continuous aqueous phase of the composition. The percent saturation of an active antibacterial agent in any composition, including a surfactant-containing composition, can theoretically be expressed as:% saturation = [C / Cs] x 100% where C refers to the antibacterial agent in The concentration in the composition and Cs refers to the saturated concentration of the antibacterial agent in the composition at room temperature. Once the percent saturation, or relative thermodynamic activity or relative chemical potential, of the antibacterial active agent dissolved in the surfactant-containing composition is the same, it is the same everywhere in the composition. Therefore, the terms "saturation" in the composition " in the composition ", " in the continuous aqueous phase of the composition " and " in the colloidal particle pseudophase of the composition " are interchangeable, and are disclosed throughout the article It is used in the same way. The difference in thermodynamic activity of the active antibacterial agent between the composition and the target tissue (please read the note on the back? Matters before filling this page)
I 1 n nMff I -12-I 1 n nMff I -12-
經濟部智慧財產局員工消費合作社印製 546149 五、發明說明(10) 異最大(亦即,當組合物被活性成分所更飽和)時,即達到 最大抗菌效能。影響抗菌活性的第二因素爲組合物中所i 可用活性劑的總量,其可視爲、'臨界劑量,,。因此,影: 組合物中活性劑的抗菌效能之兩項關鍵因素爲:(i = 用率,爲由其熱力學活性來決定,亦即,在—細合物的= 續水相中之百分飽和度,與(2)溶液中可用活性劑的總 量。 〜 抗菌清潔組合物中的一重要成分爲界面活性劑,其可作 爲一增溶劑,清潔劑和發泡劑。界面活性劑影響溶液中抗 菌劑的百分飽和度,或更重要者,影響組合物連續水相^ 的活性劑之百分飽和度。這種影響可以用水難溶性抗菌劑 在其中該活性劑爲分佈在水相(亦即連續相)與膠微粒假相 之間的界面活性劑水溶液中之情況來解釋。對於在水中溶 ~度極低的抗菌劑’如tricl〇san,其分佈會強二 膠微粒(亦即,大量的㈣。san分子會存在界 微粒中,如與水相相對者)。 界面活性劑對抗菌劑的比例直接決定界面活性劑膠微粒 中活性劑的含量,其轉而影響活性劑在連續水相中的百分 飽和度。經發現當界面活性劑的比値增加時,相對於活2 分子的膠微粒數也增加,其中隨該比例的增加,膠微粒被 活性劑飽和的程度會成比例地減少。由於在連續相中的= 性劑與在膠微粒假相中的活性劑係呈相平衡,因此當抗菌 劑在膠微粒相中的飽和度降低時,抗菌劑在連續相中的: 和度也會降低。反之亦然。經溶解在膠微粒假相中的活性 -13- (請先閱讀背面之注咅?事項再填寫本頁)Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 V. Description of the invention (10) The greatest difference (that is, when the composition is more saturated by the active ingredient), the maximum antibacterial effect is achieved. The second factor affecting the antibacterial activity is the total amount of active agents available in the composition, which can be considered as the 'critical dose'. Therefore, the two key factors of the antibacterial efficacy of the active agent in the composition are: (i = utilization rate, which is determined by its thermodynamic activity, that is,-in the fine compound = percentage in the water phase Saturation, and (2) the total amount of active agents available in the solution. ~ An important ingredient in the antibacterial cleaning composition is the surfactant, which can be used as a solubilizer, detergent and foaming agent. The surfactant affects the solution The percent saturation of the antibacterial agent in the medium, or more importantly, affects the percent saturation of the active agent in the continuous aqueous phase of the composition. This effect can be a water-insoluble antibacterial agent in which the active agent is distributed in the aqueous phase ( (Ie the continuous phase) and the pseudophase of the colloidal particles in the aqueous solution of the surfactant. The antibacterial agent with very low solubility in water, such as tricloxasan, has a stronger distribution than the colloidal particles (ie, A large amount of ㈣.san molecules will be present in the boundary particles, such as the opposite of the water phase.) The ratio of surfactant to antibacterial agent directly determines the content of the active agent in the surfactant gel particles, which in turn affects the active agent in continuous water One hundred in the phase Saturation. It has been found that when the ratio of the surfactant is increased, the number of colloidal particles relative to the living molecule also increases. As the ratio increases, the degree of saturation of the colloidal particles by the active agent decreases proportionally. In the continuous phase, the = agent and the active agent system in the colloidal particle pseudophase are in phase equilibrium, so when the saturation of the antibacterial agent in the colloidal particle phase is reduced, the antibacterial agent in the continuous phase will also be reduced. The reverse is also true. The activity after dissolving in the colloidal particles pseudo--13- (Please read the note on the back? Matters before filling out this page)
)46149 A7 B7 五、發明說明(11 劑不能立即用來與微生物拉 活性劑百分飽和丄::此時係由連續水相中的 I白刀飽和度來決疋組合物的抗菌活性。不過,界面 膠微粒中的活性劑可用爲活性劑的儲存處而於連續 水相中的活性劑耗乏時予以補充。 ^先前依賴傳統活性抗菌劑來產生效能的抗菌組合物相 路者’本發明組合物和不依賴彼等活性抗菌劑,彼等於本 發=中係作爲選用成份。本發明組合物係依賴一由多㈣ ^ 的組合,且較佳者其中該增溶 劑對該多羥基溶劑的比例爲約1:1到約6:1。若含有時,該 選用抗菌劑在室溫下測量所得含量爲至少2%飽和度。 界 本發明、心物爲具有改良抗革蘭氏陰性菌和革蘭氏陽性 菌效能的抗菌組合物,且其展現出快速細菌殺滅性。如下 列具體實例中所闡示者,本發明抗菌組合物包括:⑷約 1重量%到約50重量%的多録溶劑;⑻^重量。/。到約 5〇重量%的增溶劑;(〇約〇 到約25重量%的 面活性劑;(d) 0重量%到約5重量%的抗菌劑;與( 該 線 水。該界面活性劑較佳者爲陰離子界面活性劑。不過〜 界面活性劑的本質並非限制性,尤其當該組合物中的增: 劑對多羥基溶劑重量比爲約1:1到約6:1,且較佳者約丨5q 到約5:1之時。 如果組合物中含有活性抗菌劑時,本發明組合物且有在 室溫下測量所得至少約2% ’且較佳者至少約娜的抗菌 劑在連續水相中之百分飽合度。本發明組合物展現出在 30秒接觸後約爲2的革蘭氏陽性菌對數衰減値。本發明租 -14- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公爱 546149 經濟部智慧財產局員工消費合作社印製 A7 B7____ 五、發明說明(12 ) 合物在3 0秒接觸後展現出約2.5的革蘭氏陰性菌對數衰減 値。 多羥基溶劑 多藉基溶劑在抗菌組合物中的含量爲組合物重量的約 1 %到約50%,較佳者約5 %到約25%。爲達到本發明的完 整優點,此多羥基溶劑的含量爲組合物重量的約5 %到約 15% 〇 如本文所用者,”多羥基溶劑”一詞爲含2到6個,典型 者含2或3個經基的水溶性有機化合物。”水溶性” 一詞指 该多餐基溶劑在25。(:下具有至少〇· 1克多羥基溶劑每1 〇 〇 克水的水溶度。對於多羥基溶劑的水溶度沒有上限,亦 即’夕經基溶劑能以任何比例溶於水。 因此’’·多羥基溶劑,,包括水溶性二醇,三醇和多元醇。 夕每基各劑的特別例子包括,但不限於,乙二醇,丙二 醇,甘油,二乙二醇,二丙二醇,三丙二醇,己二醇, 工,3· 丁一醇’ 14-丁二醇,1,2,6·己三醇,山梨糖醇,peG-4 ’ PEG_6,和類似的多羥基化合物。 增溶劑 除了多羥基溶劑之外,本發明抗菌組合物還含有一增溶 劑。增溶劑的含量爲高達增溶劑在2yC的水中之溶解度, 典型者達到組合物重量的約1 %到約5〇%,較佳者約5 %到 約30%。爲達到本發明的完整優點,該增溶劑的含量爲組 合物重量的約10%到約30%。 增落劑爲一種能增加其他化合物水溶性的化合物。增溶 -15- 本紙張尺度適用中國國家標準(CNS)A4規格(21Q x 297公羞) 、--------------------訂---------線—▲ (請先閱讀背面之注意事項再填寫本頁) 546149 A7 、發明說明(13 ) 缺乏界面活性劑特性且典型者爲一種短鏈烷基芳基磺酸 :。增=劑的特別例子包括,但不限於,*丙苯磺酸鈉, ^、丙苯續酸錢,二甲苯續酸銨,甲苯橫酸卸,甲苯橫酸 甲苯續酸納,甲苯磺酸和二甲苯磺酸。其他可用的 增溶劑包括多蕃續酸鋼,聚苯乙晞續酸#内,甲基莕確酸鋼 和琥珀酸二鈉。 •、於本發明較佳實例中,增溶劑對多羥基溶劑的重量比爲 :1到、々6,1 ’較佳者約1.5:1到約5:1。爲達到本發明的 凡整優點,增溶劑對多羥基溶劑的比例爲約2:1到約4:1。 2 ^ /合劑對多每基溶劑重量比例之内時,界面活性劑的 本質並不受PM,】。而在此增溶劑對多幾基溶劑重量比例之 外時,較佳界面活性劑爲陰離子界面活性劑。 界面活性 i上所述,除了多羥基溶劑和增溶劑之外,本發明抗微 生物組合物還包含一界面活性劑。該界面活性劑的含量爲 口物的为1重f %到約2 5重量%,較佳者約2重量❶/❶到約 2 〇重量%。馬達到本發明的完整優點,該抗菌組合物含 有約2重量%到約丨5重量%的界面活性劑。 即可使用的組合物典型地含有組合物約i重量%到約i 〇 重里/〇,較佳者約1 ·5重量❶/❶到約5重量%,且最佳者約j 5 重里/〇到、、、勺3重里〇/0的界面活性劑。適合稀釋用的濃縮組 合物典型地含有大於約5重量%的界面活性劑。 於較佳實例中,界面活性劑的量係經決定成使得,若含 有時,孩選用的抗菌劑在組合物連續水相中的百分飽和度 (請先閱讀背面之注意事項再填寫本頁) · 線· 經濟部智慧財產局員工消費合作社印製 -16- 546149 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明(14 ) 爲至少約2 %,較佳者至少約25% ,且最佳者至少約 5 0 % 〇 界面活性劑的本質不限制。特別者,當增溶劑對多羥基 ’谷劑的重量比爲約1: i到約6:1時,該界面活性劑可爲陰離 子界面活性劑,陽離子界面活性劑,非離子界面活性劑或 界面活性劑的相容混合物。在彼等重量比例之内,該界面 活性劑也可以爲一在酸性溶液中呈陽離子,在鹼性溶液中 呈陰離子的兩離性界面活性劑(amph〇lytic surfactant ),或 爲兩端帶相反電荷,根據組合物的p Η値來表現酸或鹼特 性的兩離性界面活性劑(amph〇teric surfactant)。在這種比 例之外,較佳界面活性劑爲陰離子界面活性劑。 因此,該抗菌組合物最好含有一陰離子界面活性劑其帶 有一疏水性部份體,如一含有約8到約3 0個碳原子且特別 者含約1 2到約2 0個碳原子的碳鏈,且更帶有一親水性部 分體,如硫酸根,磺酸根,碳酸根,磷酸根,或羧酸根。 該疏水性碳鏈常被醚化,如用環氧乙烷或環氧丙烷,以賦 予特別的物理特性,如增加水溶性或降低對陰離予界面活 性劑的表面張力。 因此,適宜的陰離子界面活性劑包括,但不限於,下列 已知類別化合物:如烷基硫酸鹽,烷基醚硫酸鹽,烷基醚 磺酸鹽,烷基苯氧基聚氧化乙烯乙醇硫酸酯,從-烯烴磺 酸鹽,卢-烷氧基烷磺酸鹽,烷基芳基磺酸鹽,烷基甘油 單硫酸酯,烷基甘油單磺酸酯,烷基碳酸鹽,烷基醚羧酸 鹽,脂肪酸,磺酸基琥珀酸鹽,肌胺酸鹽,辛氧基醇或壬 -17- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) --------訂---------線—▲ (請先閱讀背面之注意事項再填寫本頁) 546149 經濟部智慧財產局員工消費合作社印製 A7 -------Β7 五、發明說明(15 ) 氧基醇磷酸鹽,牛磺酸鹽,脂肪牛磺酸酯,脂肪酸醯胺基 多氧化乙烯硫酸酯,經基乙續酸鹽,或其混合物。其他陰 離子界面活性劑列於McCutche〇n,s Emulsifiers and Detergents,1993 Annuals,(後文逕稱 McCutche〇n,s), McCutcheon Division, MC Publishing Co.? Glen Rock, NJ? pp. 263-266 ’其併於本文作爲參考。許多其他陰離子界面活 性劑,和陰離子界面活性劑類別,亦揭示在Laughlin以& 美國專利第3,929,678號中,其併於本文作爲參考。 特別較佳的陰離子界面活性劑含有不多於2莫耳的乙氧 基且可從下列界面活性劑類別中選出:^/以烷基硫酸 酯,6<18脂肪酸鹽,有i或2個乙氧基的。/以烷基醚硫 酸酯,CVCu燒銨氧化物,CfCi8燒醯基肌胺酸醋,C8_Cu ㈣酸基乙酸鹽’ Cs-Cu續酸基琥珀酸鹽,Cs-Cu垸基二苯 醚一崎故@曰鹽,Cs-Cu垸基碳酸g旨,•晞烴續酸酉旨 鹽,磺酸甲基酯鹽,及其混合物。C8_Ci8烷基包括8到16 個碳原子且可以爲直鏈(例如,月桂基)或支鏈(例如,2 _ 乙基己基)者。陰離子界面活性劑的陽離子可以爲鹼金屬 (較佳者鈉或鉀),銨,Cl-C4烷基銨(單,雙-,三_),或 C1-C3烷醇銨(單_,雙_,三_)。可用鋰和鹼土陽離子(= 如,鎂),但抗菌效能會降低。 特別較佳的陰離子界面活性劑包括,但不限於,月桂基 硫酸酯鹽,辛基硫酸酯鹽,八乙基己基硫酸酯鹽,月桂 胺氧化物,癸基硫酸鹽,十三跪基硫酸自旨鹽,椰酸鹽,月 桂醯基肌胺酸鹽,月桂基磺酸基琥珀酸酯鹽,線型C 一 (請先閱讀背面之注音?事項再填寫本頁)) 46149 A7 B7 V. Description of the invention (11 agents cannot be used to immediately saturate the active agent with the microorganisms: :: At this time, the antibacterial activity of the composition is determined by the saturation of the white blade in the continuous aqueous phase. However, The active agent in the interfacial colloidal particles can be used as a storage place for the active agent and supplemented when the active agent in the continuous aqueous phase is depleted. ^ An antibacterial composition phaser who previously relied on a traditional active antibacterial agent to produce efficacy 'The invention The composition and the antibacterial agent that do not depend on them are equal to the hair and medium as an optional ingredient. The composition of the present invention relies on a combination of polyamines, and it is preferable that the solubilizing agent and polyhydric solvent The ratio is about 1: 1 to about 6: 1. If it is contained, the selected antibacterial agent is measured at room temperature to obtain a content of at least 2% saturation. According to the present invention, the heart substance has improved resistance to Gram-negative bacteria and An antibacterial composition having gram-positive bacteria efficacy and exhibiting rapid bacterial killing. As illustrated in the following specific examples, the antibacterial composition of the present invention includes: more than about 1% to about 50% by weight Recording solvent; ⑻ ^ weight To about 50% by weight of solubilizer; (0 to about 0 to about 25% by weight of a surfactant; (d) 0% to about 5% by weight of an antibacterial agent; and (the line water. The interfacial activity The preferred agent is an anionic surfactant. However, the nature of the surfactant is not limiting, especially when the weight ratio of the agent to the polyhydroxy solvent is from about 1: 1 to about 6: 1, and The best is about 5q to about 5: 1. If the composition contains an active antibacterial agent, the composition of the present invention has at least about 2% of the measured value at room temperature, and preferably at least about Jona ’s antibacterial agent. Percent saturation in the continuous aqueous phase. The composition of the present invention exhibits a logarithmic decay of Gram-positive bacteria of about 2 after 30 seconds of contact. The present invention is -14- This paper is scaled to the Chinese National Standard (CNS ) A4 size (210 X 297 Public Love 546149 Printed by A7 B7____ of the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Description of the invention (12) The compound exhibited a logarithmic decay of Gram-negative bacteria of about 2.5 after 30 seconds of contact The content of the polyhydroxy solvent and the multi-based solvent in the antibacterial composition is About 1% to about 50% by weight of the composition, preferably about 5% to about 25%. To achieve the full advantages of the present invention, the content of the polyhydroxy solvent is about 5% to about 15% by weight of the composition. As used herein, the term "polyhydric solvent" is a water-soluble organic compound containing 2 to 6, typically 2 or 3 radicals. The term "water-soluble" refers to the multi-based solvent at 25. : Has a water solubility of at least 0.1 g of a polyhydric solvent per 100 g of water. There is no upper limit for the water solubility of a polyhydric solvent, that is, 'Evening-based solvents can dissolve in water in any proportion. Therefore, "· Polyhydroxy solvents, including water-soluble diols, triols, and polyols. Specific examples of each base include, but are not limited to, ethylene glycol, propylene glycol, glycerol, diethylene glycol, dipropylene glycol, tripropylene glycol, and hexane. Diol, Ig, 3 · butanediol '14-butanediol, 1,2,6 · hexanetriol, sorbitol, peG-4' PEG-6, and similar polyols. Solubilizer In addition to the polyhydroxy solvent, the antibacterial composition of the present invention contains a solubilizer. The content of the solubilizer is as high as the solubility of the solubilizer in 2 μC of water, which typically ranges from about 1% to about 50% by weight of the composition, preferably from about 5% to about 30%. To achieve the full advantages of the present invention, the solubilizer is present at a level of from about 10% to about 30% by weight of the composition. Swelling agents are compounds that increase the water solubility of other compounds. Solubilization -15- This paper size applies to China National Standard (CNS) A4 specifications (21Q x 297 male shame), -------------------- Order ---- ----- Line— ▲ (Please read the precautions on the back before filling out this page) 546149 A7, Description of Invention (13) It lacks the characteristics of surfactant and is typically a short-chain alkyl aryl sulfonic acid :. Specific examples of enhancers include, but are not limited to, * sodium propene benzene sulfonate, ^, propionate, ammonium xylate, ammonium toluene acid, sodium toluene acid, toluene acid, toluene sulfonic acid, and Xylene sulfonic acid. Other usable solubilizers include polysuccinic acid steel, polyphenylene succinic acid, methyl succinic acid steel and disodium succinate. • In a preferred embodiment of the present invention, the weight ratio of the solubilizer to the polyhydroxy solvent is: 1 to, 々6,1 ', preferably about 1.5: 1 to about 5: 1. To achieve the advantages of the present invention, the ratio of solubilizer to polyhydric solvent is from about 2: 1 to about 4: 1. When the weight ratio of the mixture to the solvent per base is more than 2, the nature of the surfactant is not affected by PM,]. When the weight ratio of the solubilizer to the multi-base solvent is different, the preferred surfactant is an anionic surfactant. Interfacial activity i As mentioned above, in addition to the polyhydroxy solvent and the solubilizing agent, the anti-microbiological composition of the present invention also contains a surfactant. The content of the surfactant is from 1% by weight to about 25% by weight, preferably from about 2% by weight to about 20% by weight. Horses achieve the full advantage of the present invention, and the antibacterial composition contains from about 2% to about 5% by weight of a surfactant. Ready-to-use compositions typically contain the composition from about i% by weight to about i0 weight% / 〇, preferably about 1.5 weight% / ❶ to about 5 weight%, and most preferably about j 5 weight% /. Surfactant to 3, 0, 0 scoop. Concentrated compositions suitable for dilution typically contain greater than about 5% by weight of a surfactant. In a preferred embodiment, the amount of surfactant is determined such that, if contained, the percent saturation of the antibacterial agent selected in the continuous aqueous phase of the composition (please read the precautions on the back before filling this page) ) · Line · Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs-16- 546149 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (14) is at least about 2%, preferably at least about 25% And the best is at least about 50%. The nature of the surfactant is not limited. In particular, when the weight ratio of the solubilizer to the polyhydroxyl cereal is about 1: i to about 6: 1, the surfactant may be an anionic surfactant, a cationic surfactant, a nonionic surfactant or an interface. A compatible mixture of active agents. Within their weight ratios, the surfactant can also be an ampholytic surfactant that is cationic in an acidic solution and anionic in an alkaline solution, or has opposite ends. The charge is an amphoteric surfactant that exhibits acidic or basic properties according to pΗ 値 of the composition. In addition to this ratio, preferred surfactants are anionic surfactants. Therefore, the antibacterial composition preferably contains an anionic surfactant with a hydrophobic moiety, such as a carbon containing about 8 to about 30 carbon atoms, and in particular a carbon containing about 12 to about 20 carbon atoms. Chain, and more with a hydrophilic moiety, such as sulfate, sulfonate, carbonate, phosphate, or carboxylate. The hydrophobic carbon chain is often etherified, such as with ethylene oxide or propylene oxide, to impart special physical properties, such as increasing water solubility or reducing the surface tension of the anionic surfactant. Accordingly, suitable anionic surfactants include, but are not limited to, the following known classes of compounds: such as alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates, alkylphenoxy polyoxyethylene ethanol sulfates , From-olefin sulfonate, lu-alkoxyalkane sulfonate, alkylaryl sulfonate, alkyl glycerol monosulfate, alkyl glycerol monosulfonate, alkyl carbonate, alkyl ether carboxylate Acid salt, fatty acid, sulfosuccinate, sarcosinate, octyl alcohol or non-17- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ----- --- Order --------- line- ▲ (Please read the notes on the back before filling out this page) 546149 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 ------- B7 5 2. Description of the invention (15) Oxyalcohol phosphate, taurate, fatty taurate, fatty acid amidopolyoxyethylene sulfate, triacetylacetate, or mixtures thereof. Other anionic surfactants are listed in McCutcheon, s Emulsifiers and Detergents, 1993 Annuals, (hereinafter referred to as McCutcheon, s), McCutcheon Division, MC Publishing Co.? Glen Rock, NJ? Pp. 263-266 ' It is incorporated herein by reference. Many other anionic surfactants, and classes of anionic surfactants, are also disclosed in Laughlin & U.S. Patent No. 3,929,678, which is incorporated herein by reference. Particularly preferred anionic surfactants contain no more than 2 moles of ethoxy and can be selected from the following surfactant categories: ^ / alkyl sulfate, 6 < 18 fatty acid salt, i or 2 ethyl Oxy. / With alkyl ether sulfate, CVCu ammonium oxide, CfCi8 burned sarcosinate, C8_Cu acetic acid acetate 'Cs-Cu continuous acid succinate, Cs-Cu fluorinated diphenyl ether Izaki So @ -salt, Cs-Cu fluorinated carbonic acid g, 晞 alkane dicarboxylic acid, sulfonium salt, sulfonic acid methyl ester salt, and mixtures thereof. C8_Ci8 alkyl includes 8 to 16 carbon atoms and can be straight chain (eg, lauryl) or branched chain (eg, 2-ethylhexyl). The cation of the anionic surfactant can be an alkali metal (preferably sodium or potassium), ammonium, Cl-C4 alkylammonium (mono, bis-, tri_), or C1-C3 alkanolammonium (mono_, bis_ ,three_). Lithium and alkaline earth cations (= eg, magnesium) are available, but the antibacterial effect is reduced. Particularly preferred anionic surfactants include, but are not limited to, lauryl sulfate, octyl sulfate, octaethylhexyl sulfate, laurylamine oxide, decyl sulfate, and tridecyl sulfate. Purpose salt, coconut salt, lauryl sarcosinate, lauryl sulfosuccinate salt, linear C one (Please read the note on the back? Matters before filling out this page)
訂---------線—I -18-Order --------- line—I -18-
546149546149
五、發明說明(16 ) (請先閲讀背面之注意事項再填寫本頁)V. Description of the invention (16) (Please read the notes on the back before filling this page)
本酸二磺酸醋鹽,月桂基磺酸基琥珀酸酯鹽,月桂醚硫酸 酯鹽(1和2莫耳環氧乙烷),肉豆蔻基硫酸酯鹽,油酸 鹽’硬脂酸鹽’牛磺酸鹽,蓖麻油酸鹽,鯨蠟基硫酸鹽, 及類似的界面活性劑。界面活性劑的其他例子載於,,CTFADisulfonic acid vinegar salt, lauryl sulfosuccinate salt, lauryl ether sulfate (1 and 2 mole ethylene oxide), myristyl sulfate, oleate 'stearate' Taurate, ricinoleate, cetyl sulfate, and similar surfactants. Other examples of surfactants are found in CTFA
Cosmetic Ingredient Handbook" J.M· Nikitakis,ed. TheCosmetic Ingredient Handbook " J.M. Nikitakis, ed. The
Cosmetic,Toiletry and Fragrance Association, Inc·, Washington,D.C. (1988)(後文 CTFAHandb〇〇k),pages 1(M3, 42_46,和87·94中,其併於本文作爲參考。 該抗菌組合物也可包含非離子性界面活性劑。典型者, 非離子性界面活性劑含一疏水性基,例如一長鏈烷基或燒 基化芳香基,和一親水鏈其含有充足數目(亦即1至約3〇) 的乙氧基和/或丙氧基部份體。非離子界面活性劑的類別 例子包括乙氧化烷酚,乙氧化和丙氧化脂肪醇,甲基葡萄 糖的聚乙二醇醚’山梨糖醇的聚乙二醇醚,氧化乙烯·氧 化丙晞肷段共聚物’脂肪(C8_cls )酸的乙氧化酯類,環氧 乙烷與長鏈胺或醯胺的縮合產物,及其混合物。 經濟部智慧財產局員工消費合作社印製 非離子界面活性劑的例予包括,但不限於,甲基 gluceth-10,PEG-20甲基葡萄糖二硬脂酸酯,pEG 2〇甲基 葡萄糖倍半硬脂酸酯,(311_15卩&代1:11_20,〇616化-8,〇616111- 12,dodoxyn〇l-12,laureth_15,PEG-20 萬麻油,p〇ly_ sorbate 20,steareth-20,聚氧化乙烯_ 1 〇鯨蠟基醚,聚氧 化乙烯-1 0硬脂基醚,聚氧化乙烯-2 〇鯨蠟基醚,聚氧化 乙烯-1 0油基醚,聚氧化乙烯_ 2 〇油基醚,乙氧化壬酚, 或乙氧化辛酚,乙氧化十二烷酚,或乙氧化脂肪(c6_c^) -19- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 經濟部智慧財產局員工消費合作社印製 546149 A7 B7 五、發明說明(17 ) 醇,包括3到2 0環氧乙烷部分體,聚氧化乙烯-2 0異十六 烷基醚,聚氧化乙烯-2 3甘油月桂酸酯,聚氧化乙烯-2 0 甘油基硬酯酸酯,PPG-10甲基葡萄糖醚,PPG-20甲基葡 萄糖醚,聚氧化乙烯-2 0山梨糖醇單酯,聚氧化乙烯-8 0 蓖麻油,聚氧化乙烯-1 5十三烷基醚,聚氧化乙烯-6十三 虎基醚,laureth-2,laureth-3,laureth-4,PEG-3 蓖麻 油,PEG 600二油酸酯,PEG 400二油酸酯,及其混合 物0 許多其他的非離子界面活性劑載於McCutcheon、 Detergents and Emulsifiers, 1993 Annuals, published by McCutcheon Division, MC Publishing Co., Glen Rock, NJ, pp. 1-246 and 266-272;於 the CTFA International Cosmetic Ingredient Dictionary,Fourth Ed.? Cosmetic,Toiletry and Fragrance Association,Washington,D.C. (1991)(後文 CTFA Dictionary) pages 1-651 ;和 CTFA Handbook, pages 86-94, 其皆併於本文作爲參考。 除了陰離子和非離子界面活性劑之外,陽離子,兩離性 與兩性界面活性劑都可用於抗微生物組合物中。陽離子界 面活性劑包括胺氧化物和醯胺基胺氧化物,例如椰胺氧化 物,癸胺氧化物和肉豆蔻胺氧化物。 兩離性界面活性劑可以廣義地描述爲含有直鏈或支鏈脂 族基的第二和第三胺之衍生物,且其中的芳族取代基之一 含有約8到1 8個碳原子且至少一個脂族取代基包含一陰離 子水溶性基,例如,羧基,磺酸根,或硫酸根。在此説明 -20- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) - I! — — — — — - — — — II - I ·1111 - — II I--------i---_i---— — I —-- (請先閱讀背面之注意事項再填寫本頁) 546149 A7 ---— ____B7_______五、發明說明(18 ) 内的化合物例子爲3·(十二烷胺基)丙酸鈉,3-(十二烷胺 基)丙垸-1-績酸鈉,2-(十二烷胺基)乙基硫酸鈉,2·(二甲 胺基)十八烷酸鈉,3-(N-羧甲基-十二烷胺基)丙烷-1_磺酸 二鈉,十八烷亞胺基二乙酸二鈉,i _瘦甲基_2_十一烷基 咪嗅鈉,和队:^_雙(2_羥基乙基)·孓硫酸基-3_十二烷氧基丙 胺。 更特別者’有一類兩離性界面活性劑包括具有下示一般 結構式的肌胺酸鹽和牛磺酸鹽 經濟部智慧財產局員工消費合作社印製 onCosmetic, Toiletry and Fragrance Association, Inc., Washington, DC (1988) (hereinafter CTFA Handbok), pages 1 (M3, 42-46, and 87.94), which are incorporated herein by reference. The antibacterial composition is also Non-ionic surfactants may be included. Typically, non-ionic surfactants contain a hydrophobic group, such as a long-chain alkyl or alkylated aromatic group, and a hydrophilic chain containing a sufficient number (ie, 1 to About 30%) of ethoxy and / or propoxy moieties. Examples of classes of non-ionic surfactants include ethoxylated phenols, ethoxylated and propoxylated fatty alcohols, polyethylene glycol ethers of methyl glucose ' Polyethylene glycol ethers of sorbitol, ethoxylated esters of fatty (C8_cls) acids of ethylene oxide · propylene oxide segment copolymers, condensation products of ethylene oxide with long-chain amines or fluorene amines, and mixtures thereof Examples of non-ionic surfactants printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs include, but are not limited to, methyl gluceth-10, PEG-20 methyl glucose distearate, pEG 20 methyl glucose. Semistearate, (311_15 卩 & Generation 1: 11_20, 〇616 化 -8, 〇616111-12, dodoxyn〇l-12, laureth_15, PEG-20 million sesame oil, p_ly_ sorbate 20, steareth-20, polyethylene oxide_ 1 cetyl ether, polyoxidation Ethylene-10 stearyl ether, polyoxyethylene-2 cetearyl ether, polyoxyethylene-10 oleyl ether, polyoxyethylene-2 oleyl ether, ethoxylated nonylphenol, or ethoxylated octylphenol , Ethoxylated dodecyl phenol, or ethoxylated fat (c6_c ^) -19- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 B7 V. Description of the invention (17) Alcohol, including 3 to 20 ethylene oxide moieties, polyoxyethylene-20 isohexadecyl ether, polyoxyethylene-2 3 glyceryl laurate, polyoxyethylene- 2 0 glyceryl stearate, PPG-10 methyl glucosyl ether, PPG-20 methyl glucosyl ether, polyoxyethylene-2 0 sorbitol monoester, polyoxyethylene-8 0 castor oil, polyethylene oxide- 1 5 tridecyl ether, polyethylene oxide-6 tridecanthyl ether, laureth-2, laureth-3, laureth-4, PEG-3 castor oil, PEG 600 dioleic acid , PEG 400 dioleate, and mixtures thereof. Many other nonionic surfactants are contained in McCutcheon, Detergents and Emulsifiers, 1993 Annuals, published by McCutcheon Division, MC Publishing Co., Glen Rock, NJ, pp. 1- 246 and 266-272; in the CTFA International Cosmetic Ingredient Dictionary, Fourth Ed.? Cosmetic, Toiletry and Fragrance Association, Washington, DC (1991) (hereinafter CTFA Dictionary) pages 1-651; and CTFA Handbook, pages 86-94 It is incorporated herein by reference. In addition to anionic and nonionic surfactants, cationic, amphiphilic and amphoteric surfactants can be used in antimicrobial compositions. Cationic surfactants include amine oxides and amidoamine oxides, such as cocoamine oxide, decylamine oxide, and myristylamine oxide. Amphiphilic surfactants can be broadly described as derivatives of second and third amines containing linear or branched aliphatic groups, and one of the aromatic substituents contains about 8 to 18 carbon atoms and At least one aliphatic substituent includes an anionic water-soluble group, such as a carboxyl group, a sulfonate group, or a sulfate group. It is stated here that -20- This paper size applies to the Chinese National Standard (CNS) A4 (210 X 297 mm)-I! — — — — — — — — — II-I · 1111-— II I ---- ---- i ---_ i ----- — I —-- (Please read the notes on the back before filling out this page) 546149 A7 ----- ____B7_______ V. Examples of compounds in the description of the invention (18) 3 · (dodecylamino) sodium propionate, 3- (dodecylamino) propanone-1-acetate sodium, 2- (dodecylamino) ethyl sulfate, 2 · (di Methylamino) sodium octadecanoate, 3- (N-carboxymethyl-dodecylamino) propane disodium sulfonate, disodium octadecylimodiacetate, i_lean methyl _2_Undecylammonium sodium, and team: ^ _bis (2-hydroxyethyl) · fluorene sulfate-3_dodecyloxypropylamine. More specifically, there is a class of amphiphilic surfactants including sarcosinates and taurates with the general structure shown below. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy on
Me - 1 RMe-1 R
- 2 IN- R-2 IN- R
CH Y - η 其中R1爲Cn到C21烷基,R2爲氫或CVC2烷基,Y爲C02M 或S〇3M,Μ爲鹼金屬,且η爲1到3的數。 另一類兩離性界面活性劑爲有下示結構式的醯胺磺酸基 琥珀酸鹽 〇 S〇3Wα II I R1-NHCCH2-CH-C02'Na4· 下列兩離性界面活性劑類別也可使用: CH2C02'Na^CH Y-η wherein R1 is a Cn to C21 alkyl group, R2 is hydrogen or CVC2 alkyl group, Y is CO2M or S03M, M is an alkali metal, and η is a number from 1 to 3. Another class of ionic surfactants are amidosulfonic acid succinates with the structural formula shown below. 〇s〇3Wα II I R1-NHCCH2-CH-C02'Na4 · The following types of ionic surfactants can also be used. : CH2C02'Na ^
CH2CH2〇H alkoamphoglycinates -21 - 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 、 --------訂---------線丨赢 (請先閱讀背面之注意事項再填寫本頁) 546149 A7 B7 五、發明說明(19) 〇 CH2C〇2-Na + R^CNH CH2CH2jiCH2C〇2H ch2ch2oh alkoamphocarboxyglycinates 0Jl I r1cnhch2ch2n CH2CH2C02'Na^ (請先閱讀背面之注意事項再填寫本頁) .¾CH2CH2〇H alkoamphoglycinates -21-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm), -------- Order --------- Line 丨 Win (Please Read the notes on the back before filling this page) 546149 A7 B7 V. Description of the invention (19) 〇CH2C〇2-Na + R ^ CNH CH2CH2jiCH2C〇2H ch2ch2oh alkoamphocarboxyglycinates 0Jl I r1cnhch2ch2n CH2CH2C02'Na ^ (Please read the notes on the back first (Please fill out this page again). ¾
CH2CH2OH - alkoamphopropionates 〇 CH2CH2C02*Na^CH2CH2OH-alkoamphopropionates 〇 CH2CH2C02 * Na ^
R1CNHCH2CH2NCH2C〇2H ch2ch2〇h alkoamphocarboxypropionates 經濟部智慧財產局員工消費合作社印製R1CNHCH2CH2NCH2C〇2H ch2ch2〇h alkoamphocarboxypropionates Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs
OH 〇 CH2CHCH2S03-Na^OH 〇 CH2CHCH2S03-Na ^
I r1cnhch2ch2n ch2ch2〇h alkoamphopropylsulfonates -22- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 _B7_五、發明說明(20 ) o ch3Jl I R1CNH(CH2)3N"-CH2C02- ch3 alkamidopropyl betaines 經濟部智慧財產局員工消費合作社印製I r1cnhch2ch2n ch2ch2〇h alkoamphopropylsulfonates -22- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 A7 _B7_ V. Description of the invention (20) o ch3Jl I R1CNH (CH2) 3N " -CH2C02 -ch3 alkamidopropyl betaines Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs
H N o=c 1 R 3 H c ,H N o = c 1 R 3 H c,
CH •N—c 3 o s 2 H c Η H 〇——c 2 H cCH • N—c 3 o s 2 H c Η H 〇——c 2 H c
3 H alkamidopropyl hydroxysultaine 〇 R1NHCH2CH2C-0'Na> alkylaminopropionates CH2CH2C〇2* I RNH I ch2ch2c〇2h alkyliminopropionates. -23- (請先閱讀背面之注意事項再填寫本頁)3 H alkamidopropyl hydroxysultaine 〇 R1NHCH2CH2C-0'Na > alkylaminopropionates CH2CH2C〇2 * I RNH I ch2ch2c〇2h alkyliminopropionates. -23- (Please read the notes on the back before filling this page)
本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(21) 其他類的兩離性界面活性劑包括phosphobetaines及 phosphitaines 〇 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 可用於本發明中的兩離性界面活性劑之特別非限制性例 子爲椰子N-甲基牛磺酸鈉,油基N-甲基牛磺酸鈉,高油酸 N-甲基牛磺酸鈉,棕櫚醯基N-甲基牛磺酸鈉,椰子二甲基 羧甲基乙内銨鹽,月桂基二甲基羧甲基乙内銨鹽,月桂基 二甲基羧乙基乙内銨鹽,鯨蠟基二甲基羧甲基乙内銨鹽, 月桂基-雙-(2-羥基乙基)羧甲基乙内銨鹽,油基二甲基- r-羧基丙基乙内銨鹽,月桂基-雙-(2-羥基乙基)羧乙基乙内 按鹽’挪酿胺基二甲基丙基㉘内按鹽’硬脂酿胺基二甲基 丙基續内按鹽,月桂酿胺基-雙-(2 _裡基乙基)丙基橫内按 鹽,油醯胺PEG-2磺酸基丁二酸二鈉,油醯胺PEG-2磺酸 基丁二酸TEA鹽,油醯胺MIPA磺酸基丁二酸二鈉,麻油 醯胺ME A磺酸基丁二酸二鈉,十一烯醯胺ME A磺酸基丁 二酸二鈉,小麥胚醯胺ME A磺酸基丁二酸二鈉,小麥胚 醯胺PEG-2磺酸基丁二酸二鈉,異硬脂醯胺MEA磺酸基 丁二酸二鈉,麻油醯胺MEA磺酸基丁二酸二鈉,椰醯兩 性甘胺酸鹽(cocoamphoglycinate),椰醯兩性瘦基甘胺酸 鹽(cocoamphocarboxyglycinate ),月桂醯兩性甘胺酸鹽, 月桂醯兩性羧基甘胺酸鹽,癸醯兩性羧基甘胺酸鹽,椰醯 兩性丙酸鹽,椰醯兩性羧基丙酸鹽,月桂醯兩性羧基丙酸 鹽,癸醯兩性羧基丙酸鹽,二羥基乙基牛脂甘胺酸鹽,椰 醯胺基3 -羥基丙基磷酸内銨鹽二鈉,月桂醯胺基肉豆蔻 醯胺基3 -羥基丙基磷酸内銨鹽,月桂醯胺基肉豆蔻醯胺 -24- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 經濟部智慧財產局員工消費合作社印製 A7 五、發明說明(22 ) 基甘油基磷酸内銨鹽,月桂醯胺基肉豆蔻醯胺基羧基二鈉 3 -羥基丙基磷酸内銨鹽,椰醯胺基丙基一鈉亞磷酸内按 鹽,月桂醯胺基肉豆蔻醯胺基丙基一鈉亞磷酸内銨鹽,即 彼等的混合物。 載體 本發明抗菌組合物的載體包括水。 選用成分 ,本發明抗菌組合物也可包括爲諳於此技者所熟知的選用 成份。例如,本發明組合物可包含一活性抗菌劑或一醇。 這些特別的選用成分及其在組合物中的含量要在後文給予 討論。 本發明组合物也可以包含其他選用成分如染料和香味 劑其含I足以凸顯其應有的功能且不會不利地影響本發明 組合物的抗菌效能。彼等選用成分的個別含量典型者爲組 泛物的0重畺%到約5重量。/❶,且總合地爲組合物的〇重量 %到約2 0重量%。This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 V. Description of the invention (21) Other types of ionic surfactants include phosphobetaines and phosphinees 〇 (Please read the note on the back first Please fill in this page again.) Special non-limiting examples of ionic surfactants that can be used in the present invention printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs are coconut N-methyl sodium taurine and oil-based N-formaldehyde. Sodium taurate, sodium N-methyltaurate peroleate, sodium palmitate N-methyltaurine, coconut dimethylcarboxymethylhydantoin, lauryldimethylcarboxymethyl Betaine salts, Lauryl dimethyl carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl-bis- (2-hydroxyethyl) carboxymethyl betaine Salt, oleyldimethyl-r-carboxypropylhydantoin, lauryl-bis- (2-hydroxyethyl) carboxyethylhydantoin Salt 'stearin amine dimethyl propyl continued salt, laurel amine-bis- (2-triylethyl) propyl hormonal salt, oleylamine PEG-2 sulfonate Disodium succinate, TEA salt of oleylamine PEG-2 sulfosuccinic acid, disodium oleamide MIPA sulfosuccinic acid succinate, sesameamine ME A disodium sulfosuccinate, eleven Disenamine ME A disodium succinate, wheat germamine ME A disodium succinate, wheat germamine PEG-2 disodium succinate, isostearylamine MEA disodium succinate, sesameamine MEA disodium succinate, cocoamphoglycinate, cocoamphocarboxyglycinate, laurel bisexual Glycine, Laurel Amphoteric Carboxyglycinate, Decayer Amphoteric Carboxylglymate, Coconut Amphoteric Amphoterate, Coconut Amphoteric Amphoterate Carboxylate, Laurel Amphoterium Amphoteric Carboxypropionate, Decanter Amphoteric Carboxyl Propionate, dihydroxyethyl tallow glycinate, cocoamine disodium 3-hydroxypropyl betaine, disodium, lauronium myristate amino 3-hydroxypropyl betaine, lauryl Pyridyl myristate Pyridamine-24- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 Ministry of Economic Affairs A7 printed by the Bureau ’s Consumer Cooperative. V. Description of the invention (22) glyceryl glyceryl phosphate, ammonium myristyl ammonium carboxyl disodium 3-hydroxypropyl phosphate, ammonium propyl Monosodium phosphite salt, laurylamine myristylaminopropyl sodium monosodium phosphite, and their mixtures. Carrier The carrier of the antibacterial composition of the present invention includes water. Optional ingredients. The antibacterial composition of the present invention may also include optional ingredients well known to those skilled in the art. For example, the composition of the invention may comprise an active antibacterial agent or an alcohol. These particular optional ingredients and their content in the composition will be discussed later. The composition of the present invention may also contain other optional ingredients such as dyes and fragrances, which contain I enough to highlight its intended function without adversely affecting the antibacterial efficacy of the composition of the present invention. The individual content of their selected ingredients is typically from 0% by weight to about 5% by weight of the compound. / ❶, and the total is from 0% to about 20% by weight of the composition.
選用成分的種類包括,但不限於,染料,芳香劑,pH 凋節劑,增稠劑,黏度調節劑,緩衝劑,泡沫穩定劑,抗 氧化劑,皮膚碉理劑和保護劑,泡沫增強劑,螯和劑,膠 凝劑,佈透明劑,維生素,和爲諳於此技者所熟知的類似 選用成分。 選用成分的特別類別包括作爲泡沫加強劑和穩定劑的烷 醇醯胺,作爲增稠劑的樹膠和聚合物;作爲維生素的維生 素A ’ E和C ;作爲緩衝劑的無機磷酸鹽,硫酸酯和碳酸 -25- 本紙張尺度適用中國國家標準(CNS)A4規格(21q χ 297公爱)__ (請先閱讀背面之注咅?事項再填寫本頁)The types of ingredients used include, but are not limited to, dyes, fragrances, pH withers, thickeners, viscosity modifiers, buffers, foam stabilizers, antioxidants, skin conditioners and protectants, foam enhancers, Chelating agents, gelling agents, cloth clearing agents, vitamins, and similar optional ingredients are well known to those skilled in the art. Specific categories of ingredients selected include alkanolamines as foam enhancers and stabilizers, gums and polymers as thickeners; vitamins A 'E and C as vitamins; inorganic phosphates, sulfates and Carbonic acid-25- This paper is in accordance with China National Standard (CNS) A4 specification (21q χ 297 public love) __ (Please read the note on the back? Matters before filling this page)
546149546149
五、發明說明(23) 鹽,作爲螯合劑的多胺基酸和鹽,如EDTA和磷酸鹽;及 作爲p Η調節劑的酸和鹼。 較佳鹼性pH調節劑類的例子爲氨;單·,雙_,及三-烷 基胺,單,雙-,及二·燒醇胺;驗金屬和驗土金屬的氫 氧化合物;及其混合物。不過,此鹼性p H調節劑的本質 不爻限制’且技藝中已知的任何鹼性p Η調節劑都可使 用。鹼性pH調節劑的特別非限制性例子爲氨;鈉,鉀, 和鋰的氫氧化物;一乙醇胺,三乙胺;異丙醇胺;二乙醇 胺;及三乙醇胺。 較佳酸性PH調節劑類別的例子爲礦物酸和多元羧酸。 礦物酸的非限制性例子爲鹽酸,硝酸,嶙酸,和硫酸。多 元羧酸的非限制性例子爲檸檬酸,乙醇酸及乳酸。酸性 pH調節劑的本質不受限制且技藝中已知的任何酸性pH調 節劑’單獨地或組合地,都可使用。 提供組合物黏稠,泡沫增強性和泡沫穩定性的烷醇醯胺 可以爲,但不限於,椰醯胺MEa,椰醯胺DEA,大豆醯 胺DEA,月桂醯胺DEA,油醯胺MIPA,硬脂醯胺 MEA,肉莖蔻醯胺MEA,月桂醯胺MEA,癸醯胺 DEA,麻醯胺DEA,肉菫蔻醯胺DEA,硬脂醯胺DEA, 油醯胺D E A ’牛脂醯胺D E A,月桂酸胺MIP A,牛脂醯胺 ME A,異硬脂醯胺d E A,異硬脂醯胺ME A,和彼等的混 合物。 選用的抗菌劑 本發明组合物中的選用活性抗菌劑之含量爲組合物的〇 -26- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閱讀背面之注意事項再填寫本頁) -線· 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 546149 A7V. Description of the invention (23) Salts, polyamine acids and salts as chelating agents, such as EDTA and phosphate; and acids and bases as regulators of pp. Examples of preferred alkaline pH regulators are ammonia; mono-, bis-, and tri-alkylamines, mono-, bis-, and di-alkanolamines; hydroxides of metal and earth metals; and Its mixture. However, the nature of this basic pH regulator is not limited 'and any basic pH regulator known in the art can be used. Specific non-limiting examples of basic pH adjusters are ammonia; hydroxides of sodium, potassium, and lithium; monoethanolamine, triethylamine; isopropanolamine; diethanolamine; and triethanolamine. Examples of preferred categories of acidic pH regulators are mineral acids and polycarboxylic acids. Non-limiting examples of mineral acids are hydrochloric acid, nitric acid, osmic acid, and sulfuric acid. Non-limiting examples of polycarboxylic acids are citric acid, glycolic acid, and lactic acid. The nature of the acidic pH adjuster is not limited and any acidic pH adjuster 'known in the art can be used alone or in combination. The alkanolamide that provides composition viscosity, foam enhancement, and foam stability may be, but is not limited to, cocoamine MEa, cocoamine DEA, soyamine DEA, lauramine DEA, oleamide MIPA, hard Lipidamine MEA, myristylamine MEA, laurylamine MEA, decylamine DEA, melamine DEA, myristylamine DEA, stearylamine DEA, oleylamine DEA, tallowamine DEA, Laurylamine MIP A, tallowamine ME A, isostearylamine d EA, isostearylamine ME A, and mixtures thereof. Selected antibacterial agent The content of the selected active antibacterial agent in the composition of the present invention is 0-26 of the composition. This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) (please read the note on the back first) Please fill in this page for further information) -Line · Printed by the Employees 'Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7
五、發明說明(24 ) 重里/〇到为5重里%,且較佳者約〇 〇1重量%到約3重量 %。爲達到本發明的完整優點,此抗菌劑的含量爲組合物 的約0.01重量%到約1重量0/〇。 抗菌組合物可爲即可使用型組合物,其典型地含有該組 口物的0重里❹Λ到約2重量❶/❶,較佳者〇〇1重量%到約i 5重 量=,且最佳者約0·05重量重量%之抗菌劑。此 抗菌組合物也可經調配爲濃縮物,其可在使用之前用約^ 到100份的水稀釋以製得終端用途組合物。此濃縮組合物 典型地含0重量。/❶到約i 〇重量%的抗菌劑。本案申請書也 預想該終端用途組合物中含有大於2重量%的抗菌劑。 右終%含有時,本發明組合物的抗菌劑含量可爲,在室 溫下測量時,該抗菌劑在水中的飽和濃度之至少約2重量 /〇,且較佳者至少約2 5重量%。爲達到本發明的完整優 點’連續水相係經飽和著約5〇Q/。到l〇〇Q/❶的抗菌劑。連續 水相中的抗菌劑含量可定義爲組合物中的抗菌劑總量減掉 界面活性劑膠微粒中的任何抗菌劑之量。測定組合物中的 抗菌劑百分飽和度之方法要在下文揭示。 可用於本發明的抗菌劑爲酚化合物例如下述類別的化合 物; (a) 2-羥基二苯基化合物5. Description of the invention (24) The weight / 0 to 5 weight%, and preferably about 0.001% to about 3% by weight. To achieve the full advantages of the present invention, this antibacterial agent is present in an amount of from about 0.01% to about 1% by weight of the composition. The antibacterial composition may be a ready-to-use composition, which typically contains 0 to about 2 weight ❶ / ❶, preferably 0.001 to about 5 weight =, and most preferably About 0.05% by weight of the antibacterial agent. This antibacterial composition can also be formulated as a concentrate, which can be diluted with about ^ to 100 parts of water before use to make an end-use composition. This concentrated composition typically contains 0 weight. / ❶ to about 0% by weight of the antibacterial agent. This application also envisions that the end-use composition contains more than 2% by weight of an antibacterial agent. The content of the antibacterial agent in the composition of the present invention, when it is contained in the right final%, may be at least about 2 wt.%, And preferably at least about 25 wt.%, Of the saturated concentration of the antibacterial agent in water when measured at room temperature. . To achieve the full advantage of the present invention, the 'continuous aqueous phase system is saturated with about 50Q /. To 100Q / ❶ antibacterial agent. The content of antibacterial agent in the continuous aqueous phase can be defined as the total amount of antibacterial agent in the composition minus any amount of antibacterial agent in the surfactant gel particles. The method for determining the percent saturation of the antibacterial agent in the composition is disclosed below. Antibacterial agents that can be used in the present invention are phenolic compounds such as the following classes of compounds; (a) 2-hydroxydiphenyl compounds
-27- 本紙張尺度適用中國國豕標準(CNS)A4規格(21G X 297公爱) (請先閱讀背面之注咅?事項再填寫本頁)-27- This paper size is applicable to China National Standard (CNS) A4 (21G X 297 public love) (Please read the note on the back first? Matters before filling out this page)
546149 A7 B7 五、發明說明(25) 其中Y爲氯或溴,Z爲SO2H ’ NO2 ’或(^-04嫁基,r爲0到 3,〇爲0到3,ρ爲〇或1,m爲0或1,且η爲0或1。 於較佳實例中,Υ爲氯或溴,m爲〇,η爲〇或1,〇爲1 或2,r爲1或2,且ρ爲0。 於特別較佳實例中,Y爲氯,m爲0,η爲0,〇爲1,r爲 2,且ρ爲0。 一種特別有用的2 -羥基二苯基化合物具有下示結構: C1 OH Cl 且有經採用的名稱,triclosan,其市售商品名爲 IRGASAN DP100,係由 Ciba Specialty Chemicals Corp· Greensboro, NC所提供。另一有用的2 -遵基二苯基化合物 爲2,2’-二羥基-5,5·-二溴-二苯基醚。 (b ) 驗衍生物 (請先閱讀背面之注意事項再填寫本頁) --------訂·--I---I 1^ 經濟部智慧財產局員工消費合作社印製546149 A7 B7 V. Description of the invention (25) where Y is chlorine or bromine, Z is SO2H'NO2 'or (^ -04), r is 0 to 3, 0 is 0 to 3, and ρ is 0 or 1, m Is 0 or 1, and η is 0 or 1. In a preferred embodiment, rhenium is chlorine or bromine, m is 0, η is 0 or 1, 0 is 1 or 2, r is 1 or 2, and ρ is 0. In a particularly preferred embodiment, Y is chlorine, m is 0, η is 0, 0 is 1, r is 2, and ρ is 0. A particularly useful 2-hydroxydiphenyl compound has the structure shown below: C1 OH Cl has a well-known name, triclosan, which is marketed under the trade name IRGASAN DP100 and is provided by Ciba Specialty Chemicals Corp. Greensboro, NC. Another useful 2- phenyl diphenyl compound is 2,2 ' -Dihydroxy-5,5 · -dibromo-diphenyl ether. (B) Analytical derivatives (Please read the precautions on the back before filling this page) -------- Order · --I- --I 1 ^ Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs
0H0H
其中Ri爲氫,經基,Ci-CU燒基,氣基,硝> 基,苯基,或 爷基;R2爲氫,#呈基,Ci-C6跪基,或鹵基;化3爲氫’ Ci_ C6烷基,羥基,氣基,硝基或呈鹼金屬鹽或銨鹽形式的 -28 - 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 五、發明說明(26) 硫;R4爲氫或甲基且R@々 K5馬風或硝基。鹵基爲溴基或,較佳 者,氣基。 酴衍生物的特別例子& k . 付炯則于包括,但不限於,氯酚(鄰·,間_ ,對-),2,4-二氯酚,對_硝基酚,苦味酸,二甲基苯酚, 對-氯基·間-二甲基紛,甲酚(鄰_,間_,對),對-氯基_ 間-甲 ',焦兒茶酚,間苯二酚,心正己基間苯二酚,焦 五倍子酸,間-苯三酚,香芹酚,瑞香草酚,對-氯瑞香草 酴,鄰-苯基酚,鄰-宇基纷,對_氯_鄰·节基朌,驗,4_ 乙基盼和4 -苯驗績酸。其他的酚衍生物都列在w〇 98/55096中,其併於本文作爲參考。 (c ) 二苯基化合物 (請先閱讀背面之注咅?事項再填寫本頁)Wherein Ri is hydrogen, via radical, Ci-CU radical, gas radical, nitrate radical, phenyl radical, or hexyl radical; R2 is hydrogen, # is radical, Ci-C6 radical, or halogen radical; Hydrogen 'Ci_C6 alkyl, hydroxy, gas-based, nitro or -28 in the form of alkali metal salt or ammonium salt-This paper size is applicable to Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 V. Invention Note (26) Sulfur; R4 is hydrogen or methyl and R @ 々K5 horse wind or nitro. Halo is bromo or, preferably, gas. Specific examples of fluorene derivatives & k. Fu Jiongyu includes, but is not limited to, chlorophenols (o-, m-, p-), 2,4-dichlorophenol, p-nitrophenol, picric acid, Dimethylphenol, p-chloro-m-dimethylphenol, cresol (o-, m-, p-), p-chloro-m-methyl ', pyrocatechol, resorcinol, heart N-hexyl resorcinol, pyrogallic acid, m-trisorcinol, carvacrol, vanillin, p-chlorovanillin, o-phenylphenol, o-uryl, p-chloro_o- · Benzyl dihydroxanthol, tetrabenzyl, 4-ethylpananyl, and 4-benzene dibasic acid. Other phenol derivatives are listed in WO 98/55096, which is incorporated herein by reference. (c) Diphenyl compounds (Please read the note on the back? Matters before filling out this page)
R3 _線· 經濟部智慧財產局員工消費合作社印製 其中X爲硫或亞甲基,Rl和爲羥基,且R2,r,2,R3, m’ ’ r’4,r5和r’5,彼此獨立地爲氫或鹵基。二苯基 化合物的特別非限制性例子爲六氣驗(hexachlorophene ), 四氯紛(tetrachlorophene),二氯驗(dichlorophene),2,3_ 二 羥基-3,3·,5,5,-四氯苯硫醚,2,2,-二羥基-3,5·,5,5’,6,6,-六氯 苯硫醚和3,3f-二溴_5,5,·二氣-2,2,-二羥基二苯基胺。其他 的二苯基化合物列在W0 98/55096中,其併於本文作爲參 考。 29 - 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 五 發明說明(27 選用醇 (請先閱讀背面之注咅?事項再填寫本頁) 本發明抗菌組合物也可視情況含有〇重量%到約2 〇重量 %的醇。較佳實例含〇重量%到約15重量%的醇、。最佳實 例含0重量%到約1 〇重量%的消毒性醇。 如本文所定義者,名詞"醇"係經定義爲含有丨到6個碳 原子的水溶性醇。適宜的醇包括,但不限於,甲醇,乙 醇,丙醇,和異丙醇。 醇可作爲配合水的載體。醇也可使抗菌組合物具有消毒 性質。 選用的膠凝劑 --線- 此抗菌組合物也能含〇重量%到約5重量%,較佳者〇重 量%到約3重量%的膠凝劑。爲達到本發明完整優點,此 抗菌組合物含有約〇重量%到約25重量%的膠凝劑。抗菌 組合物典型地含有充足量的選用膠凝劑使得組合物成爲黏 綢的液體,凝膠或半固體以便容易塗抹並揉搓在皮膚上。 諳於此技者都知道要使組合物有合意的組合物黏度或綢密 度所需在組合物中用到的膠凝劑之類型和量。 經濟部智慧財產局員工消費合作社印製 "膠凝劑”一詞如此處與後文所用者係指能增加水性組合 物的黏度或能使一水性組合物轉變成凝膠或半固體的化合 物。因此,膠凝劑可以爲有機本質者,例如,天然樹膠或 合成聚合物,或爲無機本質者。較佳的膠凝劑爲天然的或 合成的聚合物或天然聚合物的衍生物(例如,聚丙烯酸 脂,纖維素樹脂),如 carb〇mers,polyqUaterniums,和羧 甲基纖維素(如,METHOCEL⑨產品,可得自Dow Chemical -30- 本紙張尺度適用中國國家標準(CNS)A4規格(21G X 297公釐) 546149 A7 B7 五、發明說明(28)R3 _ Line · Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs where X is sulfur or methylene, R1 and hydroxy, and R2, r, 2, R3, m '' r'4, r5 and r'5, These are independently hydrogen or halo. Particularly non-limiting examples of diphenyl compounds are hexachlorophene, tetrachlorophene, dichlorophene, 2,3_dihydroxy-3,3,5,5, -tetrachloro Phenyl sulfide, 2,2, -dihydroxy-3,5 ·, 5,5 ', 6,6, -hexachlorophenylsulfide and 3,3f-dibromo-5,5, · digas-2, 2, -dihydroxydiphenylamine. Other diphenyl compounds are listed in WO 98/55096, which is incorporated herein by reference. 29-This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 A7 Five invention instructions (27 Selection of alcohol (please read the note on the back? Matters before filling this page) Antibacterial composition of the present invention Optionally, it may also contain 0% to about 20% by weight of alcohol. Preferred examples include 0% to about 15% by weight of alcohol, and best examples contain 0% to about 10% by weight of disinfectant alcohol. As defined herein, the term " alcohol " is defined as a water-soluble alcohol containing from 1 to 6 carbon atoms. Suitable alcohols include, but are not limited to, methanol, ethanol, propanol, and isopropanol. Alcohol Can be used as a carrier with water. Alcohol can also make the antibacterial composition have disinfection properties. The gelling agent selected-thread-This antibacterial composition can also contain 0% to about 5%, preferably 0% to About 3% by weight of gelling agent. To achieve the full advantages of the present invention, this antibacterial composition contains about 0% to about 25% by weight of gelling agent. The antibacterial composition typically contains a sufficient amount of selected gelling agent to make the combination Things become sticky liquids, gels or Solid for easy application and rubbing on the skin. Those skilled in the art know the type and amount of gelling agent used in the composition to make the composition have the desired composition viscosity or silk density. The term "gelling agent" printed by the Property Cooperative Consumer Cooperative, as used herein and below, refers to a compound that can increase the viscosity of an aqueous composition or convert an aqueous composition into a gel or semi-solid. Therefore, The gelling agent may be of organic nature, such as natural gums or synthetic polymers, or of inorganic nature. Preferred gelling agents are natural or synthetic polymers or derivatives of natural polymers (eg, polyacrylic acid Grease, cellulose resin), such as carbomers, polyqUaterniums, and carboxymethyl cellulose (e.g., METHOCEL (R) products, available from Dow Chemical -30- This paper size applies to Chinese National Standard (CNS) A4 specifications (21G X 297 (Mm) 546149 A7 B7 V. Description of the invention (28)
Co·,Midland, MI) 〇 撰用的皮膚調理劑和保護劑 (請先閱讀背面之注音?事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 本發明抗菌組合物也可含有選用的皮膚調理劑和/或保 護劑。皮膚調理劑的例子包括满滑藥(emollients),例 如,肉豆蔻酸鯨樣基醋,甘油基二油酸醋,肉豆蔻酸異丙 基酯,棉羊脂,月桂酸甲基酯,PPG-9月桂酸酯,大豆硬 脂酸,棕榈酸辛基酯,和PPG-5羊毛脂酸酯。皮膚調理劑 也可以爲一保濕劑,例如葡萄糖胺和吡哆二醇。吸收性皮 膚調理劑例如,羊毛脂酸鋁鹽,玉米油,甲基矽酮 (methicone),椰子油,硬脂酸硬脂基酯,三聚甲基苯基 碎氧嫁,甘油三肉莖蔻酸酯(trimyristin ),橄欖油和合成 蠟也可以使用。除了諳於此技者所熟知的雜皮膚調理劑以 外,多類皮膚調理劑的組合,可以單獨或組合地使用。雜 皮膚調理劑的非限制性例子包括蘆薈,膽固醇,胱胺酸, 角質蛋白,卵磷脂,蛋黃,甘胺酸,PPG-12,維生素A, 柳酸,乳清酸,植物油和可溶性動物膠原。皮膚調理劑可 單獨使用,或與皮膚保護劑組合使用,例如石油,可可豆 月旨,爐甘石(calamine ),和高嶺土。皮膚保護劑也可以單 獨使用。皮膚調理劑和保護劑的其他例子可參閱"CTFA Cosmetic Ingredient Handbook'1 J.M. Nikitakis,ed·,The Cosmetic, Toiletry and Fragrance Association, Inc. ? Washington,D.C,(1988)(後文 CTFA Handbook),pages 79-85,其併於本文作爲參考。 本發明抗菌組合物不依賴於低或高的p Η値來使菌群快 -31 - 本紙張尺度適用中國國家標準(CNS)A4規格(21〇 X 297公釐) 546149 A7 B7 五、發明說明(29) (請先閱讀背面之注音?事項再填寫本頁) 速減少。本發明抗菌組合物可具有約4到約9的p Η値,但 在此ρ Η範圍的兩端’本發明組合物可能對皮膚產生刺激 或損傷與本發明組合物接觸的其他表面。相應地,本發明 抗菌組合物較佳者具有約5到約8,且更佳者約6到8的ρ Η 値。爲了達到本發明的完整優點,該抗菌組合物具有約 6.5到約7.5之pH値。 爲證明本發明抗菌組合物所提供的新且意外之結果,乃 製備以下的實施例和比較例,並測定本發明組合物控制革 蘭氏陽性菌和革蘭氏陰性菌的能力。列在以下各實施例中 的重量百分比表組合物所含各種成分的實際,或活性的重 量値。本發明組合物係經由將各種成分摻和而製備的,如 諳於此技者所知者和以下所述者。 以下的物質係用來作爲各實施例的成分。各種成分的來 源以及其簡寫都概述如下: a) 燒基聚葡萄糖甘(APG),Henkel Corp.,Hoboken,NJ, PLANTAREN 2000N UP ( ϋ = 55.53%) ^ b) 月桂基硫酸銨(ALS),Henkel Corp·,ST AND APOL A (活性水平=2 8.3 % ), 經濟部智慧財產局員工消費合作社印製 c) 二甲苯磺酸銨(AXS),Stepan Corp·,STEP ANATE AXS (活性= 40%), d) 椰醯胺基丙基乙内銨鹽(C APB),McIntyre Group, Ltd·,Chicago, IL,MACKAM 35-HP (估測 30% 活性乙内銨 鹽), e) 二丙二醇(DPG),Dow Chemical Co·,Midland,Ml, -32- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(30) f) 異丙醇(IP A), g) 單乙醇胺月桂基硫酸酯(MEALS),Albright & Wilson,Cumbria,England,EMPICOL LQ 33/F (活性 = 33%), h) 辛基酚乙氧化物,9-10莫耳EO (TX100),Union Carbide,TRITON-X 100, i) 椰酸钾(Potassium cocoate)(KCO),McIntyre Group, Ltd·,MACKADET 40-K (活性= 38.4%), j) 月桂酸鉀(KL),由月桂酸(Sigma,#L-4250,活性 度=99。8%)和氫氧化鉀製備, k) 油酸钟(KO),Norman,Fox & Co,Vernon,CA, NORFOX KO (活性度=約 80% ), l) 丙二醇(P G ),DOW Chemical Co·,USP Grade (活性 度= 99.96%), m) 椰兩性乙酸鈉(SC A) ,McIntyre Group,Ltd·, MACKAM IC-90 (活性度=約 32% ), n) 異丙苯續酸納(SCS) ,Stepan Chemical Co·, STEPANATE SCS (活性度= 44.6%), o) 月桂醚硫酸酉旨鈉,1莫耳EO (SLES-1),Henkel, STAND APOLES-1 (活性度= 25.40% ), p) 月桂醚硫酸酯鈉,2莫耳EO (SLES-2),Henkel, STANDAPOLES-2(活性度= 25.71%), q) 月桂醚硫酸酯鈉/十二烷基硫酸酯鈉(SLS/SDS ), BDH Biochemical,BDH Ltd·, Poole, England,(活性度= -33- i紙張尺度適用中國國家標準(CNS)A4規格(210 χ 297公釐) (請先閱讀背面之注音?事項再填寫本頁) 訂---------線· 經濟部智慧財產局員工消費合作社印製 546149 A7 B7 五、發明說明(31 ) 99.0%) 9 (請先閱讀背面之注音2事項再填寫本頁) r) 辛基硫酸酯鈉(SOS ),Henkel,STANDAPOL LF (活 性度= 32.90%), s) 二甲苯橫酸納(SXS) ,Stepan Chemical Co” STEP ANATE SXS (活性度= 40-42% ), t) Triclosan (TCS),IRGASAN DP-300,Ciba Specialty Chemicals Corp·,Greensboro,NC (對所用批料的 GC 檢定= 99.8-99.9% 活性 TCS ; mp=56.0-58.0 C), u) 三乙醇胺月桂基硫酸酯(TEALS) ,Henkel, ST AND APOL T (活性度= 40.1%), v) 對-氯間-二甲酚(PCMX),NIPACIDE PX-R,Nipa INC·,Wilmington,Delaware (約 100% 活性度),與 w) 水-蒸顧水或去離子水。 以下方法爲用於實施例的製備和測試之中者: 經濟部智慧財產局員工消費合作社印製 a) 抗菌產品快速殺菌(定時殺菌)活性之測定。抗菌組 合物的活性係用定時殺菌法來測量,由是對暴露在抗菌測 試組合物的受挑激生物相對於時間測定期殘存率。於此試 驗中,係將一稀釋液份的組合物在特定溫度下接觸一已知 數的試驗細菌一段指定的時間。於該期間結束之後,中和 該試驗組合物,其即阻斷組合物的抗菌活性。從原菌群計 算百分衰減値或對數衰減値。一般而言,定時殺菌法係諳 於此技者所知悉者。 本發明組合物可在0_1 00%的任何濃度測試。所用濃度之 選擇在於研究者的判斷,且適宜的濃度可由請於此技者輕 -34- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) ' 一 經濟部智慧財產局員工消費合作社印製 五、發明說明(32 ) 2決^。例如黏稠性樣品常以鄕稀釋度 稠樣品血須滌雜、上…从 阳小觀 WO毫升A品係經放置在裝有磁攪拌棒的 升”、、囷誕杯裡且若需要時,用無菌去離子水將# u 體積調至1 〇 〇真Λ 、〇 F厂7八册樣w 00毛升。所有的測試都以三重複實施,將其結 果_合,並以平均對數衰減値報告出。 接觸時間的選擇也在於研究者的判斷。可以選用任何接 觸時間。典型的接觸時間從15秒到5分鐘,而以3 = 分鐘=典型的接觸時間。接觸溫度也可以爲任何溫度,典 型者爲室溫,或約25攝氏度。 、、、田菌懸浮液,或試驗菌種係經由在任何適當的固體择養 基(例如瓊脂)上培養細菌而製備的。然後將菌群用無菌°生 里食I水從瓊如上洗下來且將細菌懸浮液的菌群調整到約 1〇8菌落形成單位每毫升(cfu /毫升)。 下表列出以下試驗所用的試驗菌種且包括細菌名稱, ATCC (American Type Culture collection)的鑑定號碼,及 後文所用生物的縮寫名。 微生物名稱 ATCC # 寫 _ 金育色葡旬球菌 (Staphylococcus aureus) 6538 S. aureus 大腸样菌(Escherichia coli) 11229 E. coli 肺炎克雷伯氏菌 (Klebsiella pneumoniae) 10031 K. pneum. 豬霍亂沙門氏菌 (Salmonella choleraesuis) 10708 --------- S. choler. 金育色葡萄球菌舄一革蘭氏陽性菌,而大腸桿菌,肺炎克 - 35- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 五、發明說明(33 ) 雷伯氏菌,和豬霍亂沙門氏菌皆爲革蘭氏陰性菌。 裝有試驗組合物的燒坏係經放置在水浴中 溫 時),或放在磁攪摔器(如果周圍實驗室的溫度爲適宜 時)。然後於此樣品内接種1〇毫升的試驗細菌懸浮液。將 該菌種和試驗組合物混合攪掉一預定的接觸時間。當接觸 時間終止時,將i.O毫升的試驗組合物/細菌混合物轉移到 9· 0 笔升 Tryptone-Histidine-Tween 中和劑溶液(THT )。然後 施以十倍數的稀釋到可計數的範園。此稀釋率可依不同的 生物體而異。以三重複在TSA+板上(TSA+爲含卵磷脂與Co., Midland, MI) 〇 skin conditioner and protector (please read the note on the back? Matters before filling out this page) printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, the antibacterial composition of the present invention may also contain optional Skin conditioner and / or protective agent. Examples of skin conditioners include emollients, such as cetyl myristate, glyceryl dioleate, isopropyl myristate, cotton tallow, methyl laurate, PPG- September Laurate, Soy Stearate, Octyl Palmitate, and PPG-5 Lanolinate. The skin conditioner may also be a humectant, such as glucosamine and pyridoxine. Absorptive skin conditioners such as aluminum lanate, corn oil, methylone, coconut oil, stearyl stearate, trimethylol, triglyceride Trimyristin, olive oil and synthetic waxes can also be used. In addition to the complex skin conditioning agents known to those skilled in the art, a combination of multiple types of skin conditioning agents can be used alone or in combination. Non-limiting examples of heterodermal skin conditioners include aloe vera, cholesterol, cystine, keratin, lecithin, egg yolk, glycine, PPG-12, vitamin A, salicylic acid, orotic acid, vegetable oil, and soluble animal collagen. Skin conditioners can be used alone or in combination with skin protection agents such as petroleum, cocoa beans, calamine, and kaolin. Skin protectants can also be used alone. Other examples of skin conditioners and protective agents can be found in " CTFA Cosmetic Ingredient Handbook'1 JM Nikitakis, ed., The Cosmetic, Toiletry and Fragrance Association, Inc.? Washington, DC, (1988) (hereinafter CTFA Handbook), pages 79-85, which are incorporated herein by reference. The antibacterial composition of the present invention does not rely on low or high p Η 値 to make the flora fast -31-This paper size applies Chinese National Standard (CNS) A4 specification (21 × X 297 mm) 546149 A7 B7 V. Description of the invention (29) (Please read the Zhuyin on the back? Matters before filling out this page) The antibacterial composition of the present invention may have a p Η 値 of about 4 to about 9, but at both ends of this ρ Η range, the composition of the present invention may cause irritation to the skin or damage other surfaces in contact with the composition of the present invention. Accordingly, the antibacterial composition of the present invention preferably has a ρ 値 约 of about 5 to about 8, and more preferably about 6 to 8. To achieve the full advantage of the present invention, the antibacterial composition has a pH of about 6.5 to about 7.5. In order to prove the new and unexpected results provided by the antibacterial composition of the present invention, the following examples and comparative examples were prepared and the ability of the composition of the present invention to control Gram-positive bacteria and Gram-negative bacteria was measured. The weight percentages listed in the following examples are the actual or active weights of the various ingredients contained in the composition. The composition of the present invention is prepared by blending various ingredients, as known to those skilled in the art and described below. The following substances were used as the components of the examples. The sources of various ingredients and their abbreviations are summarized as follows: a) Carbopolyglucosamine (APG), Henkel Corp., Hoboken, NJ, PLANTAREN 2000N UP (ϋ = 55.53%) ^ b) ammonium lauryl sulfate (ALS), Henkel Corp., ST AND APOL A (activity level = 2 8.3%), printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs c) ammonium xylene sulfonate (AXS), Stepan Corp ·, STEP ANATE AXS (activity = 40% ), D) Cocamidopropyl betaine (C APB), McIntyre Group, Ltd., Chicago, IL, MACKAM 35-HP (estimated 30% active betaine salt), e) dipropylene glycol ( DPG), Dow Chemical Co., Midland, Ml, -32- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 V. Description of the invention (30) f) Isopropanol ( IP A), g) monoethanolamine lauryl sulfate (MEALS), Albright & Wilson, Cumbria, England, EMPICOL LQ 33 / F (activity = 33%), h) octylphenol ethoxylate, 9-10 Mo Ear EO (TX100), Union Carbide, TRITON-X 100, i) Potassium cocoate (KCO), McIntyre Group, Ltd., MACKADET 40- K (activity = 38.4%), j) potassium laurate (KL), prepared from lauric acid (Sigma, # L-4250, activity = 99.8%) and potassium hydroxide, k) oleic acid bell (KO) , Norman, Fox & Co, Vernon, CA, NORFOX KO (activity = about 80%), l) propylene glycol (PG), DOW Chemical Co., USP Grade (activity = 99.96%), m) coconut amphoteric acetic acid Sodium (SC A), McIntyre Group, Ltd., MACKAM IC-90 (activity = approximately 32%), n) Sodium cumene (SCS), Stepan Chemical Co ·, STEPANATE SCS (activity = 44.6% ), O) sodium lauryl ether sulfate, 1 mole EO (SLES-1), Henkel, STAND APOLES-1 (activity = 25.40%), p) sodium lauryl ether sulfate, 2 mole EO (SLES- 2), Henkel, STANDAPOLES-2 (activity = 25.71%), q) sodium lauryl ether sulfate / dodecyl sulfate (SLS / SDS), BDH Biochemical, BDH Ltd., Poole, England, (activity Degree = -33- i Paper size applies to Chinese National Standard (CNS) A4 (210 x 297 mm) (Please read the phonetic on the back? Please fill in this page for the matter) Order --------- Line · Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 B7 V. Invention Description (31) 99.0%) 9 (Please read the Note 2 on the back first Please fill in this page for further information) r) Sodium octyl sulfate (SOS), Henkel, STANDAPOL LF (activity = 32.90%), s) Sodium xylene xanthate (SXS), Stepan Chemical Co ”STEP ANATE SXS (activity = 40-42%), t) Triclosan (TCS), IRGASAN DP-300, Ciba Specialty Chemicals Corp., Greensboro, NC (GC verification of the batch used = 99.8-99.9% active TCS; mp = 56.0-58.0 C ), U) Triethanolamine lauryl sulfate (TEALS), Henkel, ST AND APOL T (activity = 40.1%), v) p-Chloro-m-xylenol (PCMX), NIPACIDE PX-R, Nipa INC · , Wilmington, Delaware (approximately 100% activity), and w) Water-distilled water or deionized water. The following methods were used in the preparation and testing of the examples: Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy a) Determination of the rapid bactericidal (timed sterilization) activity of antibacterial products. The activity of the antibacterial composition is measured by the timed sterilization method Therefore, the survival rate of the challenged organisms exposed to the antibacterial test composition with respect to time is determined. In this test, a diluted liquid composition is contacted with a known number of test bacteria at a specific temperature for a specified period of time. After the end of this period, neutralize the test composition, which blocks the antibacterial activity of the composition. Calculate the percentage decay 値 or log decay 値 from the original flora. Generally speaking, the time sterilization method is used for Those skilled in the art know. The composition of the present invention can be tested at any concentration between 0 and 100%. The choice of concentration is based on the judgment of the researcher, and the appropriate concentration can be determined by the skilled person. National Standard (CNS) A4 specification (210 X 297 mm) '' Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (32) 2 ^. For example, viscous samples are often diluted with 鄕 to thicken blood samples. Detergent, top ... From Yang Xiaoguan WO ml A strain is placed in a liter equipped with a magnetic stir bar ", and in a Christmas cup, if necessary, adjust the volume of # u to 100% with sterile deionized water. True Λ, 〇F factory 78 Book sample w 00 gross liters. All tests were performed in triplicate, and their results were combined and reported as the average log attenuation 値. The choice of exposure time also lies in the judgement of the researcher. Any contact time can be selected. Typical contact time is from 15 seconds to 5 minutes, and 3 = minutes = typical contact time. The contact temperature can also be any temperature, typically room temperature, or about 25 degrees Celsius. Bacterium suspensions, or test strains are prepared by culturing bacteria on any suitable solid selection medium (such as agar). The colonies were then washed from the above with sterile water I and the colonies of the bacterial suspension were adjusted to approximately 108 colony forming units per milliliter (cfu / ml). The following table lists the test bacteria used in the following tests and includes the names of the bacteria, the identification number of ATCC (American Type Culture collection), and the abbreviations of the organisms used later. Microbial name ATCC # write_ Staphylococcus aureus 6538 S. aureus Escherichia coli 11229 E. coli Klebsiella pneumoniae 10031 K. pneum. Salmonella choleraesuis) 10708 --------- S. choler. Staphylococcus aureus-Gram-positive bacteria, while E. coli, pneumoniae-35- This paper size applies to Chinese National Standard (CNS) A4 Specifications (210 X 297 mm) 546149 A7 V. Description of the invention (33) R. brevis and Salmonella choleraes are Gram-negative bacteria. Burnouts containing the test composition are placed in a water bath or at a magnetic stirrer (if the temperature in the surrounding laboratory is appropriate). This sample was then inoculated with 10 ml of a test bacterial suspension. The strain and the test composition are mixed and stirred for a predetermined contact time. When the contact time has expired, 1.0 ml of the test composition / bacterial mixture is transferred to a 9.0 penl Tryptone-Histidine-Tween neutralizer solution (THT). Ten-fold dilutions were then applied to the countable range. This dilution rate can vary from organism to organism. Triplicate on TSA + plate (TSA + for lecithin and
Polysorbate 80 的 Trypticase Soy Agar )選擇稀釋物。再將諸 版溫浸2 5 ± 2小時,並計算殘留的菌落數並計算百分衰減 値或對數衰減値。對照計數(數字對照)係經由用ΤΗτ替 代試驗組合物按上述程序操作而測定。用標準微生物學方 法將數字對照和樣品的板計數値分別轉換c fu/毫升。 用以下公式計算對數衰減値 對數衰減値=l〇glQ (數字對照値)_ 1〇gi◦(試驗樣品殘存値) 下表將菌群的百分衰減値關聯到丨〇 g衰減値: (請先閲讀背面之注意事項再填寫本頁) -線· 經濟部智慧財產局員工消費合作社印製 %衰減値 Log衣減値 90 1 99 2 99.9 3 99.99 4 99.999 5 b ) T C S飽和水溶液的製備:於一 4升燒瓶内裝入一 3 英寸的磁攪拌棒約7.5克TCS和3升水。然後將此燒瓶放在 -36- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 ___B7 五、發明說明(34) 水浴中擾拌,加熱(40-45 °C )至少8小時。將裝有所得 T C S /水懸浮液的燒瓶從水浴中取出,並將此溫懸浮液濾 (請先閱讀背面之注意事項再填寫本頁) 經一裝有Whatman #40 (5·5公分)濾紙的c〇〇rs #32-Η的瓷Polysorbate 80 Trypticase Soy Agar). The plates were then immersed in temperature for 25 ± 2 hours, and the number of remaining colonies was calculated and the percent attenuation 値 or logarithmic decay 値 was calculated. The control count (numerical control) was determined by substituting the test composition with TZO for the procedure described above. Digital control and sample plate counts of samples were converted to cfu / ml using standard microbiology methods. Calculate the logarithmic decay using the following formula: logarithmic decay: = 10 glQ (numerical control) _ 10 ◦ ◦ (test sample residual 値) The following table associates the percentage attenuation 菌 of the flora with 〇〇g attenuation: (Please (Read the precautions on the back before filling this page) -Line · Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs, the employee's cooperative prints the% attenuation 値 Log clothing reduction 値 90 1 99 2 99.9 3 99.99 4 99.999 5 b) Preparation of TCS saturated aqueous solution: A 4-liter flask was filled with a 3-inch magnetic stir bar and about 7.5 grams of TCS and 3 liters of water. Then place this flask in -36- This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 A7 ___B7 V. Description of the invention (34) Stir in a water bath and heat (40-45 ° C ) At least 8 hours. Remove the flask containing the obtained TCS / water suspension from the water bath, and filter the warm suspension (please read the precautions on the back before filling this page) through a Whatman # 40 (5 · 5 cm) filter paper C〇〇rs # 32-Η Porcelain
Buchner漏斗。此過濾組合係經接著於一 2升眞空過濾燒 瓶,且分批進行過濾。然後濾液轉移至另一 4升的燒瓶中 冷卻。典型地,將濾液在室溫下貯存數天之後就形成 T C S細針狀晶體。 於某些定時殺菌研究中,在用於研究中之前,係將Tcs ί谷液於A hnt下再過滤。而於其他定時殺菌研究中,係將一 小量的結晶T C S保留在試驗容器中以確保溫度改變時的 飽和度。經假設此在定時殺菌試驗容器中的T c s晶體不 會影響试驗結果’因爲結晶T C S不會對細菌作用之故(亦 即,不被溶解化)。 爲測定T C S在水溶液中的濃度,乃以HPLC分析經過滤 的樣品(三重複)。用來過濾此溶液的裝置爲whatman AUTOVIAL㊣,使用0.45微米PTFE膜及玻璃微纖維預滤器 cat· No· AV125UORG。運用匹配到包括在相同流析的 HPLC上之TCS/IPA標準品之一線性回歸線段(Micr〇s〇ft EXCEL®軟體)計算T C S濃度。 經濟部智慧財產局員工消費合作社印製 c ) T C S /界面活性劑組合物水溶液的製備:於一 French方瓶中給入含有不同濃度界面活性劑和〇 3重量% T C S的溶液。將此混合物擾掉和加熱(3 5_4〇1 )數小時直 到T C S溶解爲止。用經可變變壓器控制的加熱燈來加熱 且用數位溫度計監測此溶液的溫度。攪拌然後停止,將 -37- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 經濟部智慧財產局員工消費合作社印製 A7 ____Β7 五、發明說明(35 ) T C S晶種(約1毫克)加到溶液中,並將此混合物靜置在約 20°C下。數天後,在溶液容器底可觀察到晶體,於該溶液 中已超過TCS的最大溶解度。 使0.3% TCS幾乎完全溶解化所需的大約界面活性劑濃度 係用一實驗設計予以決定,其中係對一系列樣品以2倍數 系列地減低界面活性劑濃度直到觀察到T c S在界面活性 劑中的近似飽和點爲止。然後將濃度差値(飽和値相對於 剛溶解値)予以分半直到可測得一接近T c s飽和度的終點 爲止。T C S /界面活性劑組合物的飽和點可用小規模(J 5 到1 0 0毫升)的樣品來有效地估計,但需要約6004⑼克的 樣品來獲取可靠的最終結果。因此,起始範圍係用小規模 的樣品來確立,而最終濃度係用較大規模的樣品來決定。 d )包含T C S,多輕基溶劑和增溶劑的組合物之製備: 首先將T C S溶解在組合物使用的溶劑中。然後在τ c s / -溶 劑組合物中加入水,再加入約1毫克T c S晶種,並將所得 混合物靜置在約20°c下使其結晶。在含有溶劑,增溶劑和 界面活性劑的組合物中,係依上述將tcS溶解在溶劑 中’然後將增溶劑和界面活性劑加到T c S /溶劑溶液中。 然後將所得混合物用水稀釋到總批料。如果需要時,也進 行pH調整。在室溫下攪拌此混合物約一小時,加入TcS 晶種,然後如上述使此混合物靜置結晶。此外也運用前述 之方法來測定τ C S飽和點(亦即,將界面活性劑濃度分 半)°與上述用以決定最大添加劑濃度者類似的方法在文 獻中有 口己戴。例如 ’ p H. Elworthy et al.,“Solubilization by -38- 本紙張尺度適用中國國家標準(CNS)A4規格(21G x 297公璧)-- (請先閱讀背面之注意事項再填寫本頁)Buchner funnel. This filter combination was then emptied into a 2 liter empty filter flask and filtered in batches. The filtrate was then transferred to another 4-liter flask and cooled. Typically, T C S fine needle crystals form after the filtrate is stored at room temperature for several days. In some timed sterilization studies, the Tcs ί grain solution was filtered under A hnt before being used in the study. In other timed sterilization studies, a small amount of crystalline T C S was kept in the test container to ensure saturation when the temperature changed. It is assumed that the T c s crystals in the time sterilization test container do not affect the test results' because the crystalline T C S does not affect bacteria (that is, is not dissolved). To determine the concentration of T CS in an aqueous solution, the filtered sample was analyzed by HPLC (triplicate). The device used to filter this solution was whatman AUTOVIAL㊣, using a 0.45 micron PTFE membrane and a glass microfiber pre-filter cat · No · AV125UORG. The T CS concentration was calculated using a linear regression line (Micrrosft EXCEL® software) that was matched to one of the TCS / IPA standards included on the same HPLC HPLC. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs c) Preparation of T C S / surfactant composition aqueous solution: A French square bottle was fed with a solution containing different concentrations of the surfactant and 0.3% by weight of T C S. This mixture is shaken off and heated (35-400) for several hours until T C S is dissolved. The heating was controlled by a variable transformer controlled heating lamp and the temperature of this solution was monitored with a digital thermometer. Stir and then stop. -37- This paper size applies the Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 Printed by A7 ____ Β7 of the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (35) TCS seed (About 1 mg) was added to the solution, and the mixture was left to stand at about 20 ° C. After several days, crystals were observed at the bottom of the solution container, and the maximum solubility of TCS was exceeded in the solution. The approximate surfactant concentration required to almost completely dissolve 0.3% TCS was determined using an experimental design in which the surfactant concentration was reduced by a factor of two for a series of samples until T c S was observed at the surfactant Up to the approximate saturation point. Then the concentration difference 値 (saturated 値 relative to freshly dissolved 分) is halved until a near end of T c s saturation can be measured. The saturation point of the T C S / surfactant composition can be effectively estimated with a small scale (J 5 to 100 ml) sample, but approximately 6004 ⑼g of sample is required to obtain a reliable final result. Therefore, the starting range was established using a small-scale sample, and the final concentration was determined using a larger-scale sample. d) Preparation of a composition comprising T C S, a light-based solvent and a solubilizing agent: First, T C S is dissolved in a solvent used in the composition. Water was then added to the τ c s / -solvent composition, and then about 1 mg of T c S seed crystals were added, and the resulting mixture was allowed to crystallize at about 20 ° c. In a composition containing a solvent, a solubilizing agent and a surfactant, tcS is dissolved in a solvent as described above 'and then the solubilizing agent and the surfactant are added to the TcS / solvent solution. The resulting mixture was then diluted with water to the total batch. If necessary, also adjust the pH. The mixture was stirred at room temperature for about one hour, TcS seeds were added, and the mixture was allowed to crystallize as described above. In addition, the aforementioned method is also used to determine the τ C S saturation point (that is, to halve the surfactant concentration). Similar methods to those described above to determine the maximum additive concentration have been used in the literature. For example, ‘p H. Elworthy et al.,“ Solubilization by -38- This paper size is applicable to the Chinese National Standard (CNS) A4 specification (21G x 297 cm)-(Please read the precautions on the back before filling in this page)
546149 A7 B7 五、發明說明(36) surface-active agents and its application in chemistry and biological sciences/5 Chapman and Hall, Ltd., London, pp. 62-65 (1968),描述經由觀察混合物的混濁度來測定接近飽和 度的濃度。一類似的技術爲經由用一由一裝有光束聚焦附 屬器(亦即 MINI MAGLITE® AA,MAG Instruments, California,US A)的小閃燈發出的高強度光在直角照射觀察 樣品。此方法也用在非常近似飽和的溶液以增強對在容器 底形成的少量晶體之觀察。 表2摘列出對T C S /水組合物實施的定時殺菌試驗之結 果。兩系列結果,I和11,證明T C S /水組合物中%飽和度 的影響,亦即.在一給予的試驗系列中者,%飽和度的減 少會產生伴隨的定時殺菌效能之衰減。令人驚訝者,如下 列實施例所證實,本發明組合物提供對革蘭氏陽性菌和革 蘭氏陰性菌有效的定時殺滅,即使組合物不含活性抗菌化 合物亦然。 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 -39- 本紙張尺度適用中國國家標準(CNS)A4規格(21〇 X 297公f ) 546149 A7B7 五、發明說明(37 ) 經濟部智慧財產局員工消費合作社印製 O HH ijj Η 〇 命 參 S % > 1 麥 H—^ o 离 o 濟 I 麥 0 1 Ον $ 一 U) •w 11^ 〇 U) U) Ο s 二 ο •s U\ •o U\ isv r-f p> M r 〇 Q ο •s — ¥ U\ 今 H 槔 〇 is) σ\ h-^ p o ON U\ 孝 •ο I—k OJ Lh 唸 o •私 h-^ Ln 孝 h-^ i5V «-f o •g 1-^ Lh V 1 今 ο U) Lh K) bo Lh o U\ 孝 〇 to s Lh o *U) to 1—^ KM i§v r-f > 3争 p K> V o U\ 今 *K) 00 •K) KJ\ i^v r-K 麟 4-JS Lh 今 40 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閱讀背面之注意事項再填寫本頁) 訂---------線. 546149 A7 __ B7 五、發明說明(38) 比較表2和表3的數據顯示在極低的T C S濃度下(即,5 到10 ppm),與含較高水平τ C S的樣品比較,其定時殺菌 的效能降低。例如,表2中一含有0.93 ppm TCS的樣品與 大腸捍菌接觸1 5秒後的對數衰減値爲0.44,而表3 —含有 484 ppm TCS的樣品與同樣的微生物接觸〗5秒後的對數衰 減値爲4· 13。這種效果在更短接觸期間更加明顯。另一例 子’在表3的樣品中闡示更複雜的組合物,即,50 ppm TCS (估計値)/10%PG/5%SXS vs· 448 ppm TCS (估計 値)/20%PG/10%SXS。有較高T C S濃度的樣品顯世出1分鐘 後的細菌衰減値有至少對數地增加。 表3的數據也顯示當用不同的溶劑/增溶劑於近似相同的 TCS濃度時,其效力亦有差異。表3進一步表明當組合物 中的增溶劑量比組合物中的多羥基溶劑量少,且組合物不 含抗菌劑時,該組合物即具有不良的定時殺菌效能。表3 也顯示若組合物只含多瘦基溶劑或只含增溶劑,且不含抗 菌劑時,則該組合物會有不良的定時殺菌效能。 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準(CNS)A4規格(210 x 297公釐) 546149 A7 B7 五、發明說明(39 ) 經濟部智慧財產局員工消費合作社印製 〇 ο ο 1385 895 603 723 510 484 342 110 (est) o 112 (est) TCS (ppm) 表3-溶劑及/或增溶劑系統中的TCS 5%SXS 5%SXS 75.00%PG 50.00%PG 50.00%PG 47.52%PG 45.05%PG 44.20%PG 42.53%PG 41.86%PG 40.01%PG 23.85%PG 17%IPA 17%IPA 溶劑/增溶劑 1.20/15 0.15/15 >4.49/15 >5.17/30 >4.69/15 >3.46/15 >5.17/30 >3.46/15 4.971}/302) 金黃色葡萄球菌 0.33 >4.43 2.35 0.13 >4.49 >5.17 >4.69 >3.46 >5.17 >3.46 >5.17 >4.39 0.42 >4.42 今 -1 0.35/15 0.25/15 4.45/15 4.42/30 4.21/15 >4.38/15 4.47/30 4.13/15 4.29/30 大腸样菌 -0.15 0.96 1.73 0.26 >4.65 >4.67 >4.65 >4.38 >4.67 >4.38 >4.67 2.37 -0.24 >3.56 1—^ 今 42- (請先閱讀背面之注意事項再填寫本頁)546149 A7 B7 V. Description of the invention (36) surface-active agents and its application in chemistry and biological sciences / 5 Chapman and Hall, Ltd., London, pp. 62-65 (1968), describing the observation by observing the turbidity of the mixture Determine the concentration near saturation. A similar technique involves observing the sample at right angles by using a high-intensity light from a small flash lamp equipped with a beam focusing attachment (i.e., MINI MAGLITE® AA, MAG Instruments, California, US A). This method is also used in very near saturated solutions to enhance the observation of small crystals formed on the bottom of the container. Table 2 summarizes the results of the timed sterilization test performed on the T C S / water composition. The two series of results, I and 11, demonstrate the effect of% saturation in the T C S / water composition, i.e., in a given test series, a decrease in% saturation results in a concomitant decrease in the timed bactericidal efficacy. Surprisingly, as demonstrated in the following examples, the composition of the present invention provides effective timed killing of Gram-positive and Gram-negative bacteria, even if the composition does not contain an active antibacterial compound. (Please read the precautions on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs-39- This paper size applies to China National Standard (CNS) A4 (21〇X 297 male f) 546149 A7B7 V. Description of the invention (37) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs O HH ijj 〇 〇 命 参 S% > 1 Mai H— ^ o Li o I Mai 0 1 Ον $ 1 U) • w 11 ^ 〇U ) U) Ο s two ο • s U \ • o U \ isv rf p > M r 〇Q ο • s — ¥ U \ 今 H 槔 〇is) σ \ h- ^ po ON U \ filial • ο I— k OJ Lh chanto • Private h- ^ Ln filial h- ^ i5V «-fo • g 1- ^ Lh V 1 Jin ο U) Lh K) bo Lh o U \ 孝 〇to s Lh o * U) to 1 — ^ KM i§v rf > 3pp K > V o U \ Jin * K) 00 • K) KJ \ i ^ v rK Lin 4-JS Lh Today 40 paper standards are applicable to Chinese National Standard (CNS) A4 Specifications (210 X 297 mm) (Please read the notes on the back before filling in this page) Order --------- Line. 546149 A7 __ B7 V. Description of the invention (38) Comparison Table 2 and Table 3 Data show at very low TCS concentrations (ie, 5 to 10 ppm) Samples containing higher levels compared with τ C S which time kill efficacy is reduced. For example, the logarithmic decay of a sample containing 0.93 ppm TCS in Table 2 after 15 seconds of contact with E. coli is 0.44, and Table 3—the sample of 484 ppm TCS exposed to the same microorganism in 5 seconds値 is 4.13. This effect is more pronounced during shorter exposures. Another example 'illustrates a more complex composition in the sample in Table 3, namely, 50 ppm TCS (estimated 値) / 10% PG / 5% SXS vs. 448 ppm TCS (estimated 値) / 20% PG / 10 % SXS. Samples with higher T C S concentrations showed a bacterial decay after 1 minute, with at least a logarithmic increase. The data in Table 3 also show that when different solvents / solubilizers are used at approximately the same TCS concentration, their effectiveness is also different. Table 3 further shows that when the amount of the solubilizer in the composition is less than the amount of the polyhydric solvent in the composition, and the composition does not contain an antibacterial agent, the composition has poor timing sterilization performance. Table 3 also shows that if the composition contains only a poly-based solvent or only a solubilizing agent and does not contain an antibacterial agent, the composition will have poor timing sterilization performance. (Please read the precautions on the back before filling this page) The paper size printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs applies to Chinese National Standard (CNS) A4 (210 x 297 mm) 546149 A7 B7 V. Description of the invention ( 39) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ο ο 1385 895 603 723 510 484 342 110 (est) o 112 (est) TCS (ppm) Table 3-TCS in Solvent and / or Solubilizer System 5% SXS 5% SXS 75.00% PG 50.00% PG 50.00% PG 47.52% PG 45.05% PG 44.20% PG 42.53% PG 41.86% PG 40.01% PG 23.85% PG 17% IPA 17% IPA Solvent / Solubilizer 1.20 / 15 0.15 / 15 > 4.49 / 15 > 5.17 / 30 > 4.69 / 15 > 3.46 / 15 > 5.17 / 30 > 3.46 / 15 4.971} / 302) Staphylococcus aureus 0.33 > 4.43 2.35 0.13 > 4.49 > 5.17 > 4.69 > 3.46 > 5.17 > 3.46 > 5.17 > 4.39 0.42 > 4.42 today-1 0.35 / 15 0.25 / 15 4.45 / 15 4.42 / 30 4.21 / 15 > 4.38 / 15 4.47 / 30 4.13 / 15 4.29 / 30 coliform-0.15 0.96 1.73 0.26 > 4.65 > 4.67 > 4.65 > 4.38 > 4.67 > 4.38 > 4.67 2.37 -0.24 > 3.56 1- ^ 今 42- (Please read first (Notes on the back then fill out this page)
本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(4G) 經濟部智慧財產局員工消費合作社印製 〇 502 (est) ο 50 (est) o 50 (est) o 448 (est) o (ppm) TCS 表3-溶劑及/或增溶劑系統中的TCS 14.5%DPG/10%SXS 14.5%DPG/10%SXS 10%PG/5%SCS 10%PG/5%SCS 10%PG/5%SXS 10%PG/5%SXS 20%PG/10%SXS 20%PG/10%SXS 5%SCS 5%SCS 溶劑/增溶劑 0.03/30 >3.63/30 0.05/30 >4.14/30 金黃色葡萄球菌 0.04 >3.63 -0.03 0.59 0.05 3.42 0.05 >4.14 0.05 3.64 Η—^ 今 0.26/30 >4.44/30 1.16/30 >5.25/30 大腸桿菌 0.17 >4.44 0.96 4.96 0.35 3.18 1.35 >5.25 -0.11 0.80 今 -43- (請先閱讀背面之注意事項再填寫本頁) --------訂--------- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(41 ) 經濟部智慧財產局員工消費合作社印制衣 〇 ο ο 1385 895 603 723 510 484 342 110 (est) o 112 (est) (ppm) TCS 5%SXS 5%SXS 75.00%PG 50.00%PG 50.00%PG 47.52%PG 45.05%PG 44.20%PG 42.53%PG 41.86%PG 40.01%PG 23.85%PG 17%IPA 17%IPA 溶劑/增溶劑 1.98/15 0.54/15 3.26/15 5.26/30 2.60/15 >3.44/15 4.61/30 2.96/15 4.33/30 肺炎克雷伯氏菌 >3.44 0.63 >5.04 >5.64 4.79 >3.44 >5.64 >3.44 5.29 0.89 >4.11 今 1.34/15 0.17/15 2.69/15 2.92/30 1.79/15 1.29/15 1.56/30 1.14/15 2.52/30 豬霍亂沙門氏菌 3.56 0.24 >4.59 4.33 >4.50 2.59 2.27 2.31 3.51 1.23 >3.79 今 si s S ^ ^ ^ s Ho^ -44 - (請先閱讀背面之注意事項再填寫本頁) -線· 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 Γ Α7 Β7 五、發明說明(42 ) 0 502 (est) 0 50 (est) 0 ulo (est) 0 448 (est) 0 57 TCScppm)This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 V. Description of Invention (4G) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 502 (est) ο 50 (est) o 50 (est) o 448 (est) o (ppm) TCS Table 3-TCS 14.5% DPG / 10% SXS 14.5% DPG / 10% SXS 10% PG / 5% SCS 10% in solvents and / or solubilizing systems PG / 5% SCS 10% PG / 5% SXS 10% PG / 5% SXS 20% PG / 10% SXS 20% PG / 10% SXS 5% SCS 5% SCS Solvent / Solubilizer 0.03 / 30 > 3.63 / 30 0.05 / 30 > 4.14 / 30 Staphylococcus aureus 0.04 > 3.63 -0.03 0.59 0.05 3.42 0.05 > 4.14 0.05 3.64 Η- ^ present 0.26 / 30 > 4.44 / 30 1.16 / 30 > 5.25 / 30 E. coli 0.17 > 4.44 0.96 4.96 0.35 3.18 1.35 > 5.25 -0.11 0.80 Jin-43- (Please read the precautions on the back before filling this page) -------- Order --------- This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 A7 B7 V. Description of the invention (41) Printed clothing by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 0ο ο 1385 895 603 723 510 484 342 110 (est) o 112 (est) (ppm) TCS 5% SXS 5% SXS 75.00% PG 50.00% PG 50.00% PG 47.52% PG 45.05% PG 44.20% PG 42.53% PG 41.86% PG 40.01% PG 23.85% PG 17% IPA 17% IPA Solvent / Solubilizer 1.98 / 15 0.54 / 15 3.26 / 15 5.26 / 30 2.60 / 15 > 3.44 / 15 4.61 / 30 2.96 / 15 4.33 / 30 Klebsiella pneumoniae > 3.44 0.63 > 5.04 > 5.64 4.79 > 3.44 > 5.64 > 3.44 5.29 0.89 > 4.11 present 1.34 / 15 0.17 / 15 2.69 / 15 2.92 / 30 1.79 / 15 1.29 / 15 1.56 / 30 1.14 / 15 2.52 / 30 Salmonella cholerae 3.56 0.24 > 4.59 4.33 > 4.50 2.59 2.27 2.31 3.51 1.23 > 3.79 si s S ^ ^ ^ s Ho ^ -44-(Please read the precautions on the back before filling out this page) -Line · This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 546149 Γ Α7 Β7 V. Description of the invention (42) 0 502 (est) 0 50 (est) 0 ulo (est) 0 448 (est) 0 57 TCScppm)
14.5%DPG/10%SXS14.5% DPG / 10% SXS
14.5%DPG/10%SXS14.5% DPG / 10% SXS
10%PG/5%SCS10% PG / 5% SCS
10%PG/5%SCS10% PG / 5% SCS
10%PG/5%SXS10% PG / 5% SXS
10%PG/5%SXS10% PG / 5% SXS
20%PG/10%SXS20% PG / 10% SXS
20%PG/10%SXS20% PG / 10% SXS
5%SCS5% SCS
5%SCS (請先閱讀背面之注意事項再填寫本頁) P34/30 V4.14/30 P22/30 V4.32/30 P39 V4.14 P37 V4.32 訂---------線· 經濟部智慧財產局員工消費合作社印製 P36/30 V4.14/30 0.25/30 3.17/30 0.47 V4.14 1.29 V3.68 -45- 本紙張尺度適用中國國家標準(CNS)A4規格(210 x 297公釐) 經濟部智慧財產局員工消費合作社印製 546149 A7 B7 五、發明說明(43) 下面諸實施例顯示出本發明組合物所達到的意想不到之 效益。 實施例1 此實施例進一步證明多羥基溶劑或增溶劑本身,或多羥 基溶劑和增溶劑的組合都不能提供廣效型快速作用性高效 能抗菌活性。 -46- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閱讀背面之注意事項再填寫本頁)5% SCS (Please read the notes on the back before filling this page) P34 / 30 V4.14 / 30 P22 / 30 V4.32 / 30 P39 V4.14 P37 V4.32 Order --------- Line · Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs P36 / 30 V4.14 / 30 0.25 / 30 3.17 / 30 0.47 V4.14 1.29 V3.68 -45- This paper size applies to China National Standard (CNS) A4 specifications ( 210 x 297 mm) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 B7 V. Description of the Invention (43) The following examples show the unexpected benefits achieved by the composition of the present invention. Example 1 This example further demonstrates that neither the polyhydric solvent or the solubilizer itself, or the combination of the polyhydric solvent and the solubilizer, can provide a broad-spectrum, fast-acting, high-performance antibacterial activity. -46- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page)
546149 A7 B7 五、發明說明(44 ) 經濟部智慧財產局員工消費合作社印製 ^ %時# 1 1—^ U) Η-Α 1 to 1 h—^ 一 1 1—^ Ο 1—^ 1 h-^ 00 Η-^ h—^ & 1—^ U) 1 命 參 ? 〇 ο ο Ο ο ο 1—^ Ln 〇 Q o Q o Q 1 hj o o o L/i LO hd Q 荈 ο X ιη Η—* ϋ〇 X Κ) X ιη h-k Ο X C/5 <1 Ln in X in 一 o GO X 〇〇 X 00 Lh X 00 h-^ o 00 X 00 LA 0〇 oo 00 X 00 o 〇 *U) 00 ο •U) 00 ο U) ΟΝ ο Ο •Κ) ο 匕 ·〇 o o o •s o •s o o •U) U) •o Η-Λ U) V 鄺 躺 烊 K) ι—^ is) — ρ Ο ο *U) •o o *^o On o l〇 V/l U) o 〇 o k> σ\ 鳐 ! 1 ! ! ! ! o u> Ό 1 1 1 1 o U) <ϊ ! 1 1 o On U) 1 ! ! 1 ! ! p ! | is) ! 1 p <1 -47- (請先閱讀背面之注意事項再填寫本頁) · ,線· 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(45) 實施例1清楚地顯示出單獨的多羥基溶劑,即使爲在 50%的高濃度下,也不能成爲有效的廣效型抗菌劑。類似 地,單獨的增溶劑,及多幾基溶劑和增溶劑的組合都不能 提供一有效的抗菌組合物。 實施例2 此實施例證明單獨的界面活性劑,如同單獨的多羥基溶 劑,增溶劑,或多羥基溶劑和增溶劑的摻合物一般也不能 提供一有效的廣效型抗菌組合物。 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印制衣 -48- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(46) 經濟部智慧財產局員工消費合作社印製 K) to 00 to to K) Μ U) K) to 組合物No. 4%ALS 3%KL 2.5% KO 5% SOS 1.35% ALS 1.6% SLS 0.48% SLS 0.125% SLS 0.048% SLS 界面活性劑3 > >3.61 0.18 ο 1.76 >3.97 >3.94 V 0.56 o 金黃色葡萄球菌 1分鐘的對數衰減値(定時殺菌) 0.24 1.74 ο >4.47 ο 一 0.67 0.12 o 大腸桿菌 0.15 1 1 1 1 I I 1 1 I I 1 1 1 1 1 肺炎克雷伯氏菌 0.04 1 1 1 1 1 1 1 1 1 1 1 1 1 1 面 豬霍亂沙門氏菌 -49- (請先閱讀背面之注意事項再填寫本頁) 訂---------線· 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐)546149 A7 B7 V. Description of the invention (44) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ^% 时 # 1 1— ^ U) Η-Α 1 to 1 h— ^ 1 1 1— ^ Ο 1— ^ 1 h -^ 00 Η- ^ h— ^ & 1- ^ U) 1 Life parameters? 〇ο ο Ο ο ο 1— ^ Ln 〇Q o Q o Q 1 hj ooo L / i LO hd Q 荈 ο X ιη Η -* Ϋ〇X Κ) X ιη hk Ο XC / 5 < 1 Ln in X in 1 o GO X 〇〇X 00 Lh X 00 h- ^ o 00 X 00 LA 0〇oo 00 X 00 o 〇 * U ) 00 ο • U) 00 ο U) ΟΝ ο Ο • Κ) ο · oooo • so • soo • U) U) • o Η-Λ U) V 邝 邝 烊 K) ι— ^ is) — ρ Ο ο * U) • oo * ^ o On ol〇V / l U) o 〇o k > σ \ 鳐! 1!!!! O u > Ό 1 1 1 1 o U) < ϊ! 1 1 o On U) 1!! 1!! P! | Is)! 1 p < 1 -47- (Please read the precautions on the back before filling out this page) ·, line · This paper size applies Chinese National Standards (CNS) A4 specification (210 X 297 mm) 546149 A7 B7 V. Description of the invention (45) Example 1 clearly shows that the polyhydric solvent alone is not effective even at a high concentration of 50% Broad-spectrum antimicrobial agent. Similarly, neither the solubilizer alone nor the combination of several solvents and solubilizers can provide an effective antibacterial composition. Example 2 This example demonstrates that a single surfactant, such as a polyhydric solvent alone, a solubilizer, or a blend of a polyhydric solvent and a solubilizing agent, generally cannot provide an effective broad-spectrum antibacterial composition. (Please read the precautions on the back before filling out this page) Clothing printed by the Employees ’Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs-48- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 5 Description of the invention (46) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economy K) to 00 to K) Μ U) K) to Composition No. 4% ALS 3% KL 2.5% KO 5% SOS 1.35% ALS 1.6 % SLS 0.48% SLS 0.125% SLS 0.048% SLS Surfactant 3 > > 3.61 0.18 ο 1.76 > 3.97 > 3.94 V 0.56 o Logarithmic decay of Staphylococcus aureus for 1 minute 値 (time sterilization) 0.24 1.74 ο > 4.47 ο 0.67 0.12 o E. coli 0.15 1 1 1 1 II 1 1 II 1 1 1 1 1 1 Klebsiella pneumoniae 0.04 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Salmonella cholerae-49 -(Please read the precautions on the back before filling this page) Order --------- line · This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)
546149 五、發明說明(47 ) 於此實施例中,月桂基硫酸酯鈉(S L S ),月枝基硫酸醋 銨(ALS),和辛基硫酸酯鈉(s〇s)皆爲陰離子界面活性劑 而油酸鉀(KO)和月桂酸鉀(KL)爲陰離子卸包。 實施例3 此實施例證明陰離子,非離子性,及兩性界面活性劑都 不把長:供快速作用的廣效型抗菌組合物,即使在該界面活 性劑與驗抗菌劑(即triclosan或T C S )結合時亦然。 (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印制 < -50- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7B7 五、發明說明(48 ) 經濟部智慧財產局員工消費合作社印製 U) 1 κ> U) I Η-^ 一 U) 1 Ο U) U) 00 U) U) ΟΝ U) LO U) U) U> U) 1 h-^ 命 蓥 ο Ο dd ϋΟ Ο > Η X Ο 00 G 00 C/5 S γ 巨 ο Ο Ο 隱 CO _ 00 @1 Κ) Κ) Lh k) •私 •ο Ο to U) •ο •ο π: c; c: U) 漆 U) ο ίο S ο ίο S ο ίο ο U) ο LO ο U) ο U) ο *U) o *U) o *U) Η 〇 00 U) 、/ Ο Ο ο ο h-A σ\ V Κ) Lh V U) Ό •家 ο U\ V to K) to $ 一 p> 今 ο ο Ο to ο ο Ο Ο •私 Ο 00 Κ) ο Ο U) Lh c: o U\ 00 *U) Ό 鱗 --------------------訂---------線(請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 _ B7 五、發明說明(49) 於此實施例中,sc A和CAPB爲兩性界面活性劑。 TX100和AP G爲非離子界面活性劑。meaLS,TEALS, KCO,SLES-1和SLES-2皆爲陰離子界面活性劑。實施例3 清晰地顯示大範圍的界面活性劑在與活性抗菌劑調配後不 能提供一快速作用的廣效型抗菌組合物。 實施例4 此實施例證明含有界面活性劑,增溶劑和多羥基溶劑的 組合物可提供令人驚訏的快速作用性廣效型抗菌活性。下 表係組合物4 - 1到4 - 3對比車父組合物N 〇 s · 1 - 4和2 _ 9之比 較0 ------------% (請先閱讀背面之注意事項再填寫本頁) 訂---------線· 經濟部智慧財產局員工消費合作社印製 -52- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(50) 經濟部智慧財產局員工消費合作社印制衣 -53- U) 4^ 組合物No. 0.75% ALS 0.75 % ALS 〇 4% ALS 0.5% ALS 界面活性劑3 > 5% DPG 5% DPG 20% PG ο 20% PG U) 〇 15%AXS 10% SXS ο 10% SXS 增溶劑3) >2.59 4.24 0.05 >3.61 3.84 金黃色葡 萄球菌 H-^ 今 翰: 蘇 遨 〇 Ln >4.5 1.35 0.24 >4.41 大腸桿菌 0.59 2.57 0.37 0.15 1.49 肺炎克雷 伯氏菌 ΙΓ 烊 jit 0.33 4.68 L29 0.04 2.93 豬霍亂沙 門氏菌 --------------------訂---------線 (請先閱讀背面之注意事項再填寫本頁)546149 V. Description of the invention (47) In this example, sodium lauryl sulfate (SLS), ammonium acetate sulfate (ALS), and sodium octyl sulfate (sos) are all anionic surfactants. And potassium oleate (KO) and potassium laurate (KL) are anion unloading. Example 3 This example demonstrates that anionic, nonionic, and amphoteric surfactants are not long: a broad-spectrum antibacterial composition for rapid action, even when the surfactant and antibacterial test agent (that is, triclosan or TCS) The same is true when combined. (Please read the notes on the back before filling out this page) Order printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs < -50- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7B7 V. Description of the invention (48) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs U) 1 κ > U) I Η- ^ One U) 1 〇 U) U) 00 U) U) ΟΝ U) LO U) U) U > U) 1 h- ^ Life 蓥 ο Ο dd ϋΟ Ο > Η X Ο 00 G 00 C / 5 S γ giant ο Ο Ο Hidden CO _ 00 @ 1 Κ) Κ) Lh k) • Private • ο Ο to U) • ο • ο π: c; c: U) lacquer U) ο ίο S ο ίο S ο ίο ο U) ο LO ο U) ο U) ο * U) o * U) o * U) Η 〇00 U), / Ο Ο ο ο hA σ \ V Κ) Lh VU) Ό • Home ο U \ V to K) to $ 一 p > Today ο ο Ο to ο ο Ο Ο • Private 〇 00 Κ) ο Ο U) Lh c: o U \ 00 * U) Ό Scale -------------------- Order --------- Line (Please read first Note on the back, please fill in this page again) This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 _ B7 V. Description of the invention (49) In this embodiment, sc A and CAPB Amphoteric surfactant. TX100 and AP G are non-ionic surfactants. meaLS, TEALS, KCO, SLES-1 and SLES-2 are all anionic surfactants. Example 3 clearly shows that a wide range of surfactants cannot provide a fast-acting, broad-spectrum antibacterial composition when formulated with an active antibacterial agent. Example 4 This example demonstrates that a composition containing a surfactant, a solubilizer, and a polyhydroxy solvent can provide a surprisingly fast-acting, broad-acting antibacterial activity. The following table is the composition 4-1 to 4-3 compared to the car parent composition No. 0-1-4 and 2 _ 9 comparison 0 ------------% (Please read the back Please fill in this page before ordering) Order --------- line · Printed by the Consumer Cooperatives of Intellectual Property Bureau of the Ministry of Economic Affairs-52- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ) 546149 A7 B7 V. Description of the invention (50) Printed clothing-53- U of the Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 4) Composition No. 0.75% ALS 0.75% ALS 〇4% ALS 0.5% ALS surfactant 3 > 5% DPG 5% DPG 20% PG ο 20% PG U) 〇15% AXS 10% SXS ο 10% SXS solubilizer3) > 2.59 4.24 0.05 > 3.61 3.84 Staphylococcus aureus H- ^ Jinhan : Su 遨 〇Ln > 4.5 1.35 0.24 > 4.41 E. coli 0.59 2.57 0.37 0.15 1.49 Klebsiella pneumonia ΙΓ 烊 jit 0.33 4.68 L29 0.04 2.93 Salmonella cholerae ------------- ------- Order --------- Line (Please read the notes on the back before filling this page)
本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149
五、 發明說明(51 ) 實施例1 - 4證明p G與S X S的組合不能提供有效的抗菌組 合物。總之,實施例1證明單獨的多羥基溶劑和增溶劑並 不能有效地提供抗菌組合物·實施例2 _ 9進一步證明即使 向濃度的AL S也無法單獨有效地提供抗菌組合物。不 過,實施例4 _ 1闡明多輕基溶劑,增溶劑和界面活性劑的 組合在提供廣效型快速作用性抗菌活性方面意想不到的特 性。此項關於實施例4 _ 1的抗菌效能不儘儘爲2 _ 9和b 4 的加成性抗菌特性的觀察結果揭示出本發明組合物成份的 抗菌增效功能,這爲令人吃驚和意料之外的。 實施例4 - 2和4 - 3進一步説明本發明組合物類(即實施例 4 - 2 )所證實的增效特性且證實界面活性劑和溶劑的組合 (即實施例4 - 3 )仍不足以解釋本發明組合物的抗菌活性。 如以下實施例5所説明的,本發明抗菌組合物包括多羥 基溶劑,例如二醇,如二丙二醇,增溶劑,如二甲苯磺酸 鈉,和界面活性劑如月桂基硫酸酯銨。本發明組合物可視 Nl況更包含一活性抗菌劑,如tricl〇san,以提供進一步殺 菌效能。如後文所示者,較佳界面活性劑包括陰離子界面 活性劑,如硫酸嚴,磺酸鹽等。不過,在經審愼選擇的溶 劑與增落劑之組合下’任何界面活性劑都可用在本發明組 合物中。如後文所示者,令人驚訝地發現多羥基溶劑,增 溶劑和界面活性劑的組合可提供經證實具有增效活性的高 效抗菌組合物。 實施例5 以下實施例係示範説明本發明組合物。此實施例證實當 _ _54_ 本紙張尺度適用中國國家標準(CNS)A4規格(21G X 297公爱) ------ (請先閱讀背面之注意事項再填寫本頁) 訂---------線_ 經濟部智慧財產局員工消費合作社印製 546149V. Description of the Invention (51) Examples 1 to 4 prove that the combination of p G and S X S cannot provide an effective antibacterial composition. In summary, Example 1 proves that the polyhydric solvent and the solubilizer alone cannot effectively provide the antibacterial composition. Examples 2 to 9 further prove that the antibacterial composition cannot be provided effectively alone even to the concentration of ALS. However, Example 4-1 illustrates the unexpected characteristics of the combination of multiple light-based solvents, solubilizers and surfactants in providing a broad-spectrum, fast-acting antibacterial activity. The observations on the additive antibacterial properties of Example 4_1 which are not exhaustive 2_9 and b 4 reveal the antibacterial synergistic function of the ingredients of the composition of the present invention, which is surprising and unexpected. Outside. Examples 4-2 and 4-3 further illustrate the synergistic properties demonstrated by the composition of the present invention (ie, Example 4-2) and confirm that the combination of surfactant and solvent (ie, Example 4-3) is still insufficient The antibacterial activity of the composition of the present invention is explained. As illustrated in Example 5 below, the antibacterial composition of the present invention includes a polyhydric solvent such as a diol such as dipropylene glycol, a solubilizing agent such as sodium xylene sulfonate, and a surfactant such as ammonium lauryl sulfate. The composition of the present invention may further contain an active antibacterial agent, such as tricolsan, in order to provide further bactericidal efficacy. As shown below, preferred surfactants include anionic surfactants, such as sulfate, sulfonate, and the like. However, any of the surfactants may be used in the composition of the present invention in the combination of selected solvents and builders. As shown below, it was surprisingly found that a combination of a polyhydroxy solvent, a solubilizer and a surfactant can provide a highly effective antibacterial composition which has been proven to have synergistic activity. Example 5 The following example illustrates the composition of the present invention. This implementation example is practical _ _54_ This paper size is applicable to China National Standard (CNS) A4 (21G X 297 public love) ------ (Please read the precautions on the back before filling this page) Order ---- ----- Line_ Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149
五、發明說明(52 ) 將多祕溶劑.增溶劑和界㈣性劑的組合物# 發明組合物時,選用的抗菌劑,例如tdci〇san,:形成本 中的百分飽和度可以爲低或零,而本發明組合物仍= 出高水平的抗菌活性。此實施例中所用的多聽緣劑^ 丙:醇,而界面活性劑爲月桂基硫酸酯納(在下面表4中 表爲S?或月桂基硫酸酯銨(在表4中表爲A)。增溶劑爲二 甲苯磺酸鈉。下面的表4概示出組合物的成份而表5概示 出用定時殺菌法測定的彼等組合物所具抗性。 ---------------------訂---------線. (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 -55- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(53 經濟部智慧財產局員工消費合作社印製 Μ h-H 〇 ^Tj w d o bd > 組合物 0.30 〇 ·〇 ·〇 〇 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 %TCS3) 1 〇 〇 1 K) 00 U) <25 100 TCS的%飽和度 0.50(A) 0.75 (A) 0.25 (A) 0.25 (A) 1.0(A) 0.75 (A) 12.0 (A) 9.0 (A) 6.0 (A) 3.0 (A) 1.5 (A) 0.75 (A) 10⑸ 1.5 (S) %界面活性劑3 > 14.4 14.4 14.4 <1 Lh Ui Lh LA Lh o o %多羥基溶劑3 > 一 Η-^ o o %增溶劑3) ,4 56- (請先閱讀背面之注意事項再填寫本頁) ---I---訂·--------· 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 經濟部智慧財產局員工消費合作社印制衣 A7 _B7 五、發明說明(54 ) HH ffi 〇 ^Tj W d 〇 a > 組合物 4.39/>4.77 0.79/0.9 1.7/2.19 >4.59/>4.57 >3.79/>3.79 >3.79/>3.79 >4.51^4.51 >4.51/>4.51 -/4.7 金黃色葡萄球菌 >4.71/>4.71 >4.34/>4.34 3.97/>4.70 >4.70/>4.70 >3.93/>3.93 >3.93/>3.93 >4.63/>4.63 >4.63/>4.63 /0.85 -/0.95 大腸桿菌 3.00>4.55 0.41/1.53 0.50/1.43 4.06/>4.41 .0.17/0.92 3.49/>3.69 3.74/>4·04 >4.〇4>4.04 2.71/>4.36 2.87>4.36 3.01/>4.38 4.38/>4.38 /0.75 δ 肺炎克雷伯氏菌 >4.20/>4.20 >4.〇4/>4.04 3.04/>4.04 >4.〇4/>4.04 >4.25/>4.25 >4.25/>4.25 2.95^>3.88 3.33/>3.88 -/0.92 豬霍亂沙門氏菌 ^5--^φ^ϋ^>ι30#/1 今^摩轉^第^ -57- (請先閱讀背面之注意事項再填寫本頁) 訂---------線. 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明(55) 實施例5的組合物證實溶劑,增溶劑和界面活性劑的組 合所達到的令人驚訝和意料之外的增效抗菌活性。經由包 含選用的活性抗菌劑可更改良抗菌活性。本發明組合物的 一令人驚对之處在於組合物中的抗菌劑飽合度低於2 5 % (即組合物E - Η ),甚至〇的組合物仍展現出抗菌活性。特 別者,組合物Η只含2 %飽合度的T C S。 組合物Α和Β證實雖然缺乏溶劑和增溶劑的組合物展現 出具有一些抗菌活性,但該等組合物的效能係有限者,即 使完全飽合著T C S亦然。組合物C - Η證實,有增效的溶 劑/增溶劑/界面活性劑組合時,即使組合物中酚抗菌劑 (即triclosan)的百分飽合度很低,即低於25%,仍可形成 高效力調配物。 組合物I和J説明增溶劑/多經基溶劑的重量比的影響, 組合物I的增溶劑/溶劑比例爲3 / 1且能夠高效地對抗肺炎 克雷伯氏菌,而組合物J的增溶劑/溶劑比例爲4 / 3且其對 抗同樣細菌的效能則較差。、组合物K,L和Μ爲本發明另 外的實例。再者,實施例L和Μ顯示本發明組合物可不含 活性抗菌劑而調配成且卻仍然具有對抗各種細菌的效能。 組合物Ν説明在較佳增溶劑對多羥基溶劑比例之外的本發 明有效組合物。 實施例6 下面的實施例説明本發明的其他組合物。此實施例係比 較一系列包括多羥基溶劑,界面活性劑和增溶劑的增效混 合物之組合物。某些組合物含有tricl〇san (Tcs),而某些 -58- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) ---------------------訂---------線· (請先閱讀背面之注咅?事項再填寫本頁) 546149 A7 B7 五、發明說明(56 ) 組合物不含活性抗菌劑。其結果説明本發明組合物的整體 抗菌效能。 組合物 % TCS 3} % DPG 3) % SXS 3) % ALS 3) A 0.30 5 15 0.75 B 0.0 5 15 0.75 C 0.30 5 15 1.5 D 0.0 5 15 1.5 E 0.30 5 15 3.0 F 0.0 5 15 3.0 下表摘列出實施例6的組合物抗金黃色葡萄球菌和大腸 桿菌的定時殺菌結果。 (請先閱讀背面之注意事項再填寫本頁) --------訂---------線· 經濟部智慧財產局員工消費合作社印製 -59- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(57 ) 經濟部智慧財產局員工消費合作社印製 60V. Description of the invention (52) A combination of multiple secret solvents, solubilizers, and alkaline agents # When inventing the composition, the selected antibacterial agent, such as tdciosan, can be formed with a low percent saturation Or zero, while the composition of the present invention still exhibits high levels of antibacterial activity. The multi-listening agent used in this example is propylene: alcohol, and the surfactant is sodium lauryl sulfate (S? In Table 4 below or ammonium lauryl sulfate (A in Table 4) The solubilizer is sodium xylene sulfonate. Table 4 below outlines the composition of the composition and Table 5 outlines the resistance of their compositions measured by the time sterilization method. -------- ------------- Order --------- line. (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs -55 -This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 V. Description of invention (53 printed by MH h 〇 ^ Tj wdo bd > composition of the Intellectual Property Bureau of the Ministry of Economic Affairs Employee Consumption Cooperative) 0.30 〇 · 〇〇〇0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30% TCS3) 1 〇〇1 K) 00 U) < 25 100% TCS saturation 0.50 (A) 0.75 (A) 0.25 (A ) 0.25 (A) 1.0 (A) 0.75 (A) 12.0 (A) 9.0 (A) 6.0 (A) 3.0 (A) 1.5 (A) 0.75 (A) 10⑸ 1.5 (S)% Surfactant 3 > 14.4 14.4 14.4 < 1 Lh Ui Lh LA Lh oo% Base Solvent 3 > Η- ^ oo% Solubilizer 3), 4 56- (Please read the precautions on the back before filling this page) --- I --- Order · -------- · This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 Printed clothing A7 of the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Description of the invention (54) HH ffi 〇 ^ Tj W d 〇a > Composition 4.39 / > 4.77 0.79 / 0.9 1.7 / 2.19 > 4.59 / > 4.57 > 3.79 / > 3.79 > 3.79 / > 3.79 > 4.51 ^ 4.51 > 4.51 / > 4.51-/ 4.7 Staphylococcus aureus > 4.71 / > 4.71 > 4.34 / > 4.34 3.97 / > 4.70 > 4.70 / > 4.70 > 3.93 / > 3.93 > 3.93 / > 3.93 > 4.63 / > 4.63 > 4.63 / > 4.63 /0.85-/ 0.95 E. coli 3.00 > 4.55 0.41 / 1.53 0.50 / 1.43 4.06 / > 4.41 .0.17 / 0.92 3.49 / > 3.69 3.74 / > 4.04 > 4. 〇4 > 4.04 2.71 / > 4.36 2.87 > 4.36 3.01 / > 4.38 4.38 / > 4.38 / 0.75 δ Klebsiella pneumonia > 4.20 / > 4.20 > 4.0.4 / > 4.04 3.04 />4.04 > 4.〇4 / > 4.04 > 4.25 / > 4.25 > 4.25 / > 4.25 2.95 ^ > 3.88 3.33 / > 3. 88-/ 0.92 Salmonella cholerae ^ 5-^ φ ^ ϋ ^ > ι30 # / 1 Jin ^ Mo Zhuan ^^^ -57- (Please read the notes on the back before filling this page) Order ---- ----- Line. This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (55) Example 5 The composition confirms the surprising and unexpected synergistic antibacterial activity achieved by the combination of solvents, solubilizers and surfactants. Good antibacterial activity can be changed by including an optional active antibacterial agent. A surprising pair of the composition of the present invention is that the antibacterial agent in the composition is less than 25% saturated (i.e., composition E-Η), and even the composition of 0 exhibits antibacterial activity. In particular, the composition Η contains only 2% T C S of saturation. Compositions A and B demonstrate that although compositions lacking solvents and solubilizers exhibit some antibacterial activity, the effectiveness of these compositions is limited, even if fully saturated with T C S. Composition C-Η confirmed that when a synergistic solvent / solubilizing agent / surfactant combination is used, even if the percent saturation of the phenol antibacterial agent (i.e. triclosan) in the composition is very low, that is, less than 25%, it can still form High potency formulation. Compositions I and J illustrate the effect of the weight ratio of solubilizer / polyester based solvent. The ratio of solubilizer / solvent of composition I is 3/1 and can effectively combat Klebsiella pneumoniae, while the increase of composition J The solvent / solvent ratio is 4/3 and it is less effective against the same bacteria. Compositions K, L and M are further examples of the invention. Furthermore, Examples L and M show that the compositions of the present invention can be formulated without active antibacterial agents and still have the efficacy against various bacteria. Composition N illustrates an effective composition of the invention outside the ratio of preferred solubilizer to polyhydric solvent. Example 6 The following examples illustrate other compositions of the invention. This example compares a series of synergistic compositions comprising a polyhydric solvent, a surfactant, and a solubilizer. Certain compositions contain triclsan (Tcs), and some -58- this paper size applies Chinese National Standard (CNS) A4 (210 X 297 mm) ------------- -------- Order --------- Line · (Please read the note on the back? Matters before filling out this page) 546149 A7 B7 V. Description of the invention (56) The composition does not contain activity Antibacterial agents. The results show the overall antibacterial effect of the composition of the present invention. Composition% TCS 3)% DPG 3)% SXS 3)% ALS 3) A 0.30 5 15 0.75 B 0.0 5 15 0.75 C 0.30 5 15 1.5 D 0.0 5 15 1.5 E 0.30 5 15 3.0 F 0.0 5 15 3.0 The results of the timed sterilization of the composition of Example 6 against Staphylococcus aureus and E. coli are summarized. (Please read the precautions on the back before filling out this page) -------- Order --------- Line · Printed by the Consumer Consumption Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs-59- This paper size applies China National Standard (CNS) A4 Specification (210 X 297 mm) 546149 A7 B7 V. Invention Description (57) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 60
w o o ω > 命 參 U) 00 V s U) V s U) to Lh V s m Μ 今 鄺 摩 η L) V 私 V I U) bo 00 V 1 今 V V V V V V V V V € V V V (請先閱讀背面之注意事項再填寫本頁)woo ω > Life parameter U) 00 V s U) V s U) to Lh V sm Μ 今 摩摩 η L) V Private VIU) bo 00 V 1 VVVVVVVVVVV € VVV (Please read the notes on the back before filling (This page)
本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 ~-------— B7 五、發明說明(58 ) 上面摘列的數據證明雖然實施例A_F全部都呈現出良好 的廣效型抗菌活性,含TCS的組合物(即A,c和F)表現 出略爲較優的抗菌效能因而爲較佳者。因&,本發明組合 物二在不含活性抗菌劑(即%飽合度爲〇)時展現出良好二 抗菌效能,且在含活性抗菌劑,例如Tcs,可進一步改 良本發明組合物的性能。 實施例7 此實施㈣明本發明組合物可用作手部清潔劑。此實施 例的組合物包括在含界面活性劑,多羥基溶劑和增溶劑的 組合中含抗菌劑的具體實例(即實施例7_A和7_b)。此 外’實施例7-C不含傳統抗菌劑。下表摘列出實施例7的 組合物,組合物中的唯一其他成份爲去離子 卜-----------1% C請先閱讀背面之注意事項再填寫本頁) 組合物 %TCS %DPG _%sxs O/v A T c 7-A 0.30 5 /〇 /\JLr b 7 R 0.30 1.5 5 3.0 7 Γ 0.0 5 15 3.0 組合物所得抗菌活性結果: 訂---------線. 經濟部智慧財產局員工消費合作社印製 ~1¾¾___:r2〇mmmmm 金黃色葡查^^This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 A7 ~ ----------- B7 V. Description of the invention (58) The data summarized above proves that although all of the examples A_F are It exhibits a good broad-spectrum antibacterial activity, and the TCS-containing composition (ie, A, c, and F) shows slightly better antibacterial efficacy and is therefore the better. Because of & the composition II of the present invention exhibits good secondary antibacterial efficacy when it does not contain an active antibacterial agent (ie, the% saturation is 0), and the active antibacterial agent, such as Tcs, can further improve the performance of the composition of the present invention . Example 7 This example shows that the composition of the present invention can be used as a hand cleanser. The composition of this embodiment includes a specific example of containing an antibacterial agent in a combination containing a surfactant, a polyhydroxy solvent, and a solubilizer (i.e., Examples 7_A and 7_b). In addition, 'Example 7-C is free of conventional antibacterial agents. The following table summarizes the composition of Example 7. The only other component in the composition is deionized. ----------- 1% C. Please read the precautions on the back before filling this page.) Combination % TCS% DPG _% sxs O / v AT c 7-A 0.30 5 / 〇 / \ JLr b 7 R 0.30 1.5 5 3.0 7 Γ 0.0 5 15 3.0 Composition antibacterial activity result: order ------ --- Line. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs ~ 1¾¾ ___: r2〇mmmmmm Golden Yellow Check ^^
實施例7-A到7-C都表現出良好的均質性和穩定性。在由 志願人嶋評估中實施例7.B和7_c具有優良包泡性 -61 - 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公爱 546149 A7 B7 五、發明說明(59 ) 能。如上呈資料所示者,即使爲不含活性抗菌劑trid〇san 的實施例7-C也顯示出高效廣效型抗菌效能。此外,含有 T C S百分飽合度明顯小於25%的實施例7_B也顯示出良好 的廣效型抗菌活性。此實施例説明在需要強調含有高界面 活性劑濃度和少量至無抗菌劑的本發明組合物所具其他優 點時可以製備具有低%飽合度TCS的有效抗菌組合物。 實施例8 此實施例闡不T C S %飽合度在含有多護基溶劑,增溶 劑,和界面活性劑的組合物中之影響。從下表概示的數據 中可證明抗菌效能(以定時殺菌試驗測定)的增益係與所給 組合物中抗菌劑%飽合度的增加有關。下表説明當所有其 他成份的濃度保持不變時,T C S濃度變化所產生的影 響。 (請先閱讀背面之注意事項再填寫本頁) — — — — — — — — — — — — — — — — 經濟部智慧財產局員工消費合作社印製 -62- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 B7 五、發明說明(60) 經濟部智慧財產局員工消費合作社印製 ·〇 S •ο σ\ Os o o io 00 o lo o o lo u> o 〇 Lo ?〇 o LO Η 3. g- C/3 § U) \lii# Η £ 〇 ^ 芩掷 -^λ 13¾ S & ^ W U\ ο ρ Lh X Ο , ϋ〇 Lh s U\ 00 X ϋ〇 Ο U\ hd ϋ P 00 X 00 o , 00 « s 容 GO X 00 o , 00 hd O P 〇〇 X 00 o 00 O P H-A 容 00 X j/5 o , d p h-^ Lfi X ϋ〇 〇 , ϋ〇 o p 名 lil X ϋ〇 o , 00 今 U) 兰 s g 爸 1—^ o *^ο U) h-A MD 〇\ •s U) •s •s V LA U\ V 私 Lh V V 私 l/l V U\ Lh V Ln V 私 Ln Lh V 私 l/i Lh w择 K 烊 β 參 to *U) o V U) bo K) 2 bo H-^ K) V U) bo U) •g V U) bo H-^ u> 2 bo U) bo V U) bo bo 1—^ V U) bo w ^ -63- (請先閱讀背面之注意事項再填寫本頁) 訂---------線. 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) 546149 A7 五、發明說明(61 ) 經濟部智慧財產局員工消費合作社印製 本發明抗菌組合物具有數項實際最終用途,包括=二Γ潔劑,外科清潔劑,身體去污劑,手部消: 和二的個人養護品。其他類型的組合物包括發 財:t 摩絲(mou⑽)等,及含有機和無機二::组合物如乳液,化妝水,乳霜,乳膏等。本發明 :ΐ理:::爲硬表面的抗菌清潔劑,如醫院,食堂和肉 的水槽和榧臺。本發明抗菌組合物可製成稀 釋備用的組合物,或爲使用料釋的濃墙物。 與物也可摻加一布片以製成抗菌擦件。此抗來/目潔消毒肌膚或無生命的表面。 Η #月柷菌、,且合物提供在短接觸時間内廣效殺死革蘭 和革闌氏陰性菌的優點。由用來清潔消毒皮膚和 4〒表面的典型的15到60秒時間看來,可促成實質的 菌對數衰減之短接觸時間係重要的。 因局本發明組合物不依賴於傳統活性抗菌劑來降低微 物群數所以本發明組合物可在短接觸時間内發生效用 來由於杬菌劑不存在於界面活性劑膠微粒中, 此’本發明組合物能夠立即開始降解菌群。而且,本發 組合物可不含抗菌劑,卻仍顯示出良好的抗菌性能。 下面的實施例闡示本發明各種組合物。 實施例9洗手劑組合^ 製備根據本發明適用冑洗手劑的組合物。本發明組合物 包括以下含有所示重量百分比的組合物: 菌 氏 生 因 明Examples 7-A to 7-C all showed good homogeneity and stability. In the evaluation by volunteers, Example 7.B and 7_c have excellent encapsulation -61-This paper size applies Chinese National Standard (CNS) A4 specifications (210 X 297 public love 546149 A7 B7 V. Description of the invention (59) Yes, as shown in the data above, even Example 7-C, which does not contain active antibacterial agent tridosan, exhibited a high-efficiency and broad-spectrum antibacterial effect. In addition, the examples with TCS percent saturation were significantly less than 25% 7_B also shows a good broad-spectrum antibacterial activity. This example illustrates that when it is necessary to emphasize other advantages of the composition of the present invention containing a high surfactant concentration and a small amount to no antibacterial agent, a TCS with a low% saturation can be prepared. Effective antibacterial composition. Example 8 This example illustrates the effect of TCS% saturation in a composition containing multiple base solvents, solubilizers, and surfactants. The antibacterial efficacy can be demonstrated from the data summarized in the table below The gain (measured by the time sterilization test) is related to the increase in the% saturation of the antimicrobial agent in the given composition. The following table shows the changes in the TCS concentration when the concentration of all other ingredients remains the same. (Please read the notes on the back before filling out this page) — — — — — — — — — — — — — — — — — — Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs -62- This paper size applies to China Standard (CNS) A4 specification (210 X 297 mm) 546149 A7 B7 V. Description of the invention (60) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs · 〇 σ \ Os oo io 00 o lo oo lo u > o 〇Lo? 〇o LO Η 3. g- C / 3 § U) \ lii # Η £ 〇 ^ 芩 推-^ λ 13¾ S & ^ WU \ ο Lh X Ο, ϋ〇Lh s U \ 00 X ϋ〇〇 U \ hd ϋ P 00 X 00 o, 00 «s capacity GO X 00 o, 00 hd OP 〇〇X 00 o 00 OP HA capacity 00 X j / 5 o, dp h- ^ Lfi X ϋ〇 〇, ϋ〇op name lil X ϋ〇o, 00 this U) 兰 sg daddy 1— ^ o * ^ ο U) hA MD 〇 \ • s U) • s • s V LA U \ V Private Lh VV Private / l VU \ Lh V Ln V Private Ln Lh V Private l / i Lh w Select K 烊 β Refer to * U) o VU) bo K) 2 bo H- ^ K) VU) bo U) • g VU) bo H- ^ u > 2 bo U) bo VU) bo bo 1— ^ VU) bo w ^ -63- (Please read the precautions on the back before filling (Write this page) order --------- line. This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 V. Description of invention (61) Employees of Intellectual Property Bureau, Ministry of Economic Affairs Consumer cooperatives have printed the antibacterial composition of the present invention with several practical end uses, including: ΓΓ cleanser, surgical cleanser, body detergent, and hand care products. Other types of compositions include fortune: t mousse (mou⑽), etc., and organic and inorganic 2 :: compositions such as lotions, lotions, creams, creams, etc. The present invention: ΐ 理 :: is an antibacterial cleaner for hard surfaces, such as hospitals, canteens, and meat sinks and pans. The antibacterial composition of the present invention can be made into a thinner ready-to-use composition, or a thick wall using a material release. The object can also be mixed with a piece of cloth to make an antibacterial wipe. This anti-toxin / eye cleanser disinfects skin or inanimate surfaces.柷 # 月 柷 菌, and the compound provides the advantage of extensively killing Gram and Gram-negative bacteria in a short contact time. From the typical 15 to 60 seconds used to clean and disinfect the skin and 4〒 surface, the short contact time which can cause substantial logarithmic decay of the bacteria is important. Because the composition of the present invention does not rely on traditional active antibacterial agents to reduce the number of micro-groups, the composition of the present invention can be effective in a short contact time. Since the bactericide does not exist in the surfactant gel particles, this' this The inventive composition is able to immediately begin to degrade the flora. Moreover, the composition of the present invention may contain no antibacterial agent, but still exhibit good antibacterial properties. The following examples illustrate various compositions of the invention. Example 9 Hand Sanitizer Combination ^ A composition suitable for use with a hand sanitizer according to the present invention was prepared. The composition of the present invention includes the following compositions containing the indicated weight percentages:
-64- 546149 A7 五、發明說明(62 ) 成分-64- 546149 A7 V. Description of the Invention (62) Ingredients
Triclosan 月桂基硫酸酯銨 ___三^丙二醇 二甲苯磺酸鋼 去離子水 重量百分比 0.30 0.50 14.4 10.0 適量 經濟部智慧財產局員工消費合作社印製 諸組合物的製備係經由將二丙二醇和τ C S混合至均句 (、、’勺5刀鐘)。在triclosan完全溶解後,如由不含未溶的固 體物質所證實的,將二甲苯磺酸鈉加入溶液中。然後攪拌 所得混合物至二甲苯磺酸鈉完全溶解。最後,將月桂基硫 酸酯銨和水加入所得溶液中,且攪拌組合物到均勾(約5 分鐘)。 組合物的增溶劑對溶劑重量比例爲約1 : 144,且含約 50=飽和度的tricl〇san。組合物係經由3 〇秒的接觸時間對 金黃色葡萄球菌,大腸桿菌,肺炎克雷伯氏菌和豬霍亂沙 門氏菌的定時殺菌試驗來評估其抗菌效能。諸組合物分別 展見出4.39,>4.71,3.00和>4 2〇的抗菌對數衰減値。 因此,本發明組合物顯示出優良的廣效型抗菌活性。此實 施祖實當各種成分的重量比超出較佳範圍之外時,仍可 製得本發明有效實例。不過,如本文他處所示者,較佳實 例尚提供其他優點。 實施例1 0 身體去污組合物 根據本發明適於用爲身體去污劑的組合物係用以下成分 知:下不重量百分比來製備的: - 65- x 297公釐) ---------------------訂---------線· (請先閱讀背面之注意事項再填寫本頁) 546149 五、 發明說明(63Triclosan ammonium lauryl sulfate ___ Tris propylene glycol xylene sulfonate steel deionized water weight percentage 0.30 0.50 14.4 10.0 The amount of composition printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs is prepared by dipropylene glycol and τ CS Mix until even sentences (,,, spoon 5 knife clocks). After triclosan is completely dissolved, as confirmed by the absence of undissolved solid material, sodium xylene sulfonate is added to the solution. The resulting mixture was then stirred until the sodium xylene sulfonate was completely dissolved. Finally, ammonium lauryl sulfate and water were added to the resulting solution, and the composition was stirred until homogeneous (about 5 minutes). The composition has a solubilizer to solvent weight ratio of about 1: 144 and contains about 50 = saturation of tricloxasan. The composition was evaluated for its antibacterial efficacy by a timed bactericidal test against Staphylococcus aureus, E. coli, Klebsiella pneumoniae and Salmonella cholerae through a contact time of 30 seconds. The compositions exhibited antibacterial logarithmic decay 4.3 of 4.39, > 4.71, 3.00, and > 4 2 0, respectively. Therefore, the composition of the present invention shows excellent broad-spectrum antibacterial activity. In this practice, when the weight ratio of various ingredients is out of the preferred range, an effective embodiment of the present invention can still be obtained. However, as shown elsewhere in this article, the better example offers other advantages. Example 10 0 Body decontamination composition A composition suitable for use as a body decontamination agent according to the present invention is prepared with the following ingredients: the following weight percentages:-65- x 297 mm) ----- ---------------- Order --------- Line · (Please read the notes on the back before filling this page) 546149 V. Description of the invention (63
重量百分比Weight percent
Triclosan 烷基多糖荅 0.10Triclosan alkyl polysaccharide 荅 0.10
本發明組合物係經由將trielosan,丙二醇,香味劑,和 乙醇組合,並混合諸成分直到所有triclosan都溶解,如由 不含有未溶物質看出者。然後加入二甲苯硫酸酯鈉,並攪 拌所得混合物直到二曱苯硫酸酯鈉完全溶解。最後加入烷 基多糖甞和水,並攪拌混合物直到均勻。所得組合物形成 令人清爽的身體去污劑能在使用者皮膚上提供理想的細 菌降解水平。 實施例1 1 濕擦組合物 根據本發明適於浸潰入不織布製成濕擦布的組合物可用 以下的成分按照下示重量百分比來製備: --------^---------線 —9. (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 成分 重量百分比 Triclosan 0.20 月桂基硫酸酯銨 5 二丙二醇 10 二甲苯磺酸鈉 20 去離子水 適量 該組合物的製備係經由將二丙二醇和τ c s混合均勻(約 -66- 本紙張尺度適用中國國家標準(CNS)A4規格(210><^97公釐) A7The composition of the present invention is obtained by combining trielosan, propylene glycol, flavor, and ethanol, and mixing the ingredients until all triclosan is dissolved, as seen by the absence of undissolved substances. Then, sodium xylene sulfate was added, and the resulting mixture was stirred until the sodium xylenebenzene sulfate was completely dissolved. Finally, the alkyl polysaccharide hydrazone and water were added, and the mixture was stirred until homogeneous. The resulting composition forms a refreshing body detergent that provides the desired level of bacterial degradation on the skin of the user. Example 1 1 Wet wipe composition According to the present invention, a composition suitable for being impregnated into a non-woven cloth to make a wet wipe can be prepared with the following ingredients at the weight percentages shown below: -------- ^ ---- ----- Line—9. (Please read the notes on the back before filling this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. Triclosan 0.20 ammonium lauryl sulfate 5 dipropylene glycol 10 xylene sulfonic acid Sodium 20 Deionized water in an appropriate amount The composition is prepared by mixing dipropylene glycol and τ cs (approximately -66- this paper size applies the Chinese National Standard (CNS) A4 specification (210 > < ^ 97mm) A7
546149 五、發明說明(64 ) 五分鐘)。在triclosan完全溶解後,如由不含未溶物質所 看出者,將二甲苯續酸鈉加入溶液中。然後攪拌所得組合 物直到二甲苯磺酸鈉完全溶解。最後,將月桂基硫酸酯^ 和水加入所得溶液中,並攪拌組合物至均勻(約五分鐘)。 然後將一片不織型纖維質布料(即市售紙巾)浸入組合物 中形成一溼擦物,適用於擦拭和清潔表面,例如,手或非 生物表面如櫃台。此物件形成一具有很好的清潔特性且提 供廣效型抗菌活性的良好溼擦布。 實施例1 2 洗手劑組合物 製備根據本發明適用爲洗手劑的組合物。該組合物包本 所示重量百分比下列成分: (請先閱讀背面之注意事項再填寫本頁) 成分 重量百分比 Triclosan 0.30 月桂基硫酸酯銨 6 二丙二醇 5 二甲苯磺酸鈉 15 去離子水 q.s. 該組合物的製備係經由混合二丙二醇和T c s至均勻(約 訂---------線· 經濟部智慧財產局員工消費合作社印製546149 V. Description of Invention (64) Five minutes). After triclosan is completely dissolved, as seen from the absence of undissolved material, sodium xyloxalate is added to the solution. The resulting composition was then stirred until the sodium xylene sulfonate was completely dissolved. Finally, lauryl sulfate and water were added to the resulting solution, and the composition was stirred until homogeneous (about five minutes). A piece of non-woven fibrous cloth (that is, a commercially available paper towel) is then dipped into the composition to form a wet wipe, which is suitable for wiping and cleaning surfaces, such as hands or non-biological surfaces such as counters. This article forms a good wet wipe having good cleaning characteristics and providing a broad-spectrum antibacterial activity. Example 1 2 Hand Sanitizer Composition A composition suitable for use as a hand sanitizer according to the present invention is prepared. The composition contains the following ingredients in weight percent shown: (Please read the precautions on the back before filling out this page) Ingredient weight percent Triclosan 0.30 ammonium lauryl sulfate 6 dipropylene glycol 5 sodium xylene sulfonate 15 deionized water qs this The composition is prepared by mixing dipropylene glycol and T cs until homogeneous (contracted --------- line · Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs
"I 立才鍍)。在rnciosan^全落解後糾概叹难小溶物質 合 水 Γ . 看出者’將二甲苯磺酸鈉加到溶液中。然後攪拌所得混 物至二甲苯磺酸鈉完全溶解。最後將月桂基硫酸酯銨^ 加到溶液中,並攪拌組合物至均勻(約5分鐘)。 該組合物的增溶劑對溶劑重量比爲3:丨且Mcl〇san的飽和 度約8%。該組合物係經由各一分鐘接觸時間的對金黃色 -67- 546149 A7 五、發明說明(65 葡萄球菌,大腸桿菌,肺炎克雷 I足時殺菌試驗來評估其抗菌效 的抗菌對數衣減値> 3 79,> 3 93 孩組合物顯示出優良的廣效型抗 於增溶劑對溶劑重量比及包含一 佳具體實例的優點。再者,此實 由較南濃度的界面活性劑調配成 本發明組合物在志願者洗手測試 優良的使用中皀泡穩定性。 顯然地,可以對前文所詳細説 改和變異而不達離本發明旨意和 申請專利範圍才可加以限制。 伯氏菌和豬霍亂沙門氏菌 能。該組合物顯示出個別 ’ >4.36 和 >4.25。因此, 菌活性。此實施例證明關 活性抗菌劑的本發明一較 施例證實有效的組合物可 以取得其他優點。例如, 中具有改進的良泡特性和 明的本發明列舉出許多修 範圍’且因此’只有後附 (請先閱讀背面之注咅?事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 _广 68 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐)" I was plated). After the complete solution of rnciosan ^, it is possible to sigh about the insoluble matter and water Γ. Seen by adding sodium xylene sulfonate to the solution. The resulting mixture was then stirred until the sodium xylene sulfonate was completely dissolved. Finally, ammonium lauryl sulfate was added to the solution, and the composition was stirred until homogeneous (about 5 minutes). The solubilizer-to-solvent weight ratio of the composition was 3: 1 and the saturation of Mclosan was about 8%. The composition is based on golden yellow-67- 546149 A7 for one minute contact time. V. Description of the invention (65 Staphylococcus, E. coli, Klein pneumonia I. Foot-time bactericidal test to evaluate its antibacterial logarithmic effect. > 3 79, > 3 93 The composition shows excellent broad-effect resistance to solubilizer-to-solvent weight ratio and the advantage of including a good specific example. Furthermore, it is formulated by a more concentrated surfactant The composition of the invention has excellent foaming stability in the hand-washing test of volunteers. Obviously, the foregoing can be modified and mutated without departing from the purpose of the present invention and the scope of patent application. The Bordetella and The composition of Salmonella choleraesuis. The composition exhibits individual > 4.36 and > 4.25. Therefore, the bacterial activity. This example demonstrates that an active antibacterial agent of the present invention can achieve other advantages over the exemplified effective composition. For example, the present invention with improved good bubble characteristics and clarity enumerates many repair scopes 'and therefore' only appended (please read the note on the back? Matters before filling in this ) Ministry of Economic Affairs Intellectual Property Office employees consumer cooperatives printed paper _ 68 wide scale applicable to Chinese National Standard (CNS) A4 size (210 X 297 mm)
Claims (1)
Applications Claiming Priority (2)
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US09/338,654 US6107261A (en) | 1999-06-23 | 1999-06-23 | Compositions containing a high percent saturation concentration of antibacterial agent |
US09/467,716 US6204230B1 (en) | 1999-06-23 | 1999-12-21 | Antibacterial compositions containing a solvent, hydrotrope, and surfactant |
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TW546149B true TW546149B (en) | 2003-08-11 |
Family
ID=26991293
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TW89112408A TW546149B (en) | 1999-06-23 | 2000-06-23 | Antibacterial compositions |
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AU (1) | AU5471000A (en) |
TW (1) | TW546149B (en) |
WO (1) | WO2000078141A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10617769B2 (en) | 2016-07-22 | 2020-04-14 | Tci Co., Ltd. | Bacterium-contained hydrogel and method of making the same |
CN112534031A (en) * | 2018-07-18 | 2021-03-19 | 德国德之馨香精香料公司 | Detergent composition |
Families Citing this family (7)
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US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
EP1830638A2 (en) * | 2004-12-09 | 2007-09-12 | The Dial Corporation | Compositions having a high antiviral and antibacterial efficacy |
WO2006062897A2 (en) * | 2004-12-09 | 2006-06-15 | The Dial Corporation | Compositions having a high antiviral and antibacterial efficacy |
KR20070113281A (en) | 2005-03-10 | 2007-11-28 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Antimicrobial compositions and methods |
WO2006099359A2 (en) | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of reducing microbial contamination |
WO2011071904A2 (en) * | 2009-12-09 | 2011-06-16 | Kci Licensing, Inc. | Inhibiting bacterial infection and biofilm formation |
KR102261301B1 (en) * | 2012-10-12 | 2021-06-07 | 로레알 | Cosmetic compositions containing at least one hydrotrope and at least one active compound |
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GB743984A (en) * | 1952-09-03 | 1956-01-25 | Monsanto Chemicals | Improvements relating to germicides |
DE19530833A1 (en) * | 1994-08-25 | 1996-02-29 | Ciba Geigy Ag | Surfactant mixts. for use as disinfectants |
BR9508767A (en) * | 1994-08-25 | 1997-11-11 | Ciba Geigy Ag | Surfactant formulations |
ES2375350T3 (en) * | 1996-06-04 | 2012-02-29 | Basf Se | CONCENTRATED LIQUID FORMULATIONS THAT INCLUDE A MICROBICIDLY ACTIVE INGREDIENT. |
-
2000
- 2000-06-07 WO PCT/US2000/015698 patent/WO2000078141A1/en active Application Filing
- 2000-06-07 AU AU54710/00A patent/AU5471000A/en not_active Abandoned
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10617769B2 (en) | 2016-07-22 | 2020-04-14 | Tci Co., Ltd. | Bacterium-contained hydrogel and method of making the same |
CN112534031A (en) * | 2018-07-18 | 2021-03-19 | 德国德之馨香精香料公司 | Detergent composition |
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AU5471000A (en) | 2001-01-09 |
WO2000078141A1 (en) | 2000-12-28 |
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