TW513306B

TW513306B - Cosmetic formulations useful in the prevention and therapy of hair loss and the use thereof

Info

Publication number: TW513306B
Application number: TW087105957A
Authority: TW
Inventors: Verona Giancarlo
Original assignee: Verona Giancarlo
Priority date: 1997-10-17
Filing date: 1998-04-18
Publication date: 2002-12-11
Also published as: US6270752B1; DE69806622D1; DE1023034T1; MY118589A; ITMI972353A1; CA2306628C; KR20010031128A; ATE220533T1; KR100505098B1; JP3633869B2; DK1023034T3; JP2001520178A; ES2148123T1; CA2306628A1; CN1173685C; CN1275900A; IT1295357B1; EP1023034A1; EP1023034B1; DE69806622T2

Abstract

The present invention provides new formulations useful in the prevention and therapy of hair loss and seborrhoea, which are based on essential oils obtainable through alcoholic distillation of the plants which contain the essential oils, combined with salicylic acid and with fatty acids having 10 to 14 carbon atoms.

Description

經濟部中决標準局員_τ消費合作社印f 513306 A7 B7 五、發明説明（）本發明提供一種預防及治療掉髮之新穎組合物，其係具有血管動力、抗菌及抗雄性激素活性物質之組合。從文獻K及從化粧品實務可知，掉髮係由於”帽狀腱膜”內周圍顯微循環減低、與细菌群落間之關係改變K及局部雄性激素代謝改變等負面影響所致。雄性激素，特別是在髮囊內之二羥罩固嗣之沈澱增加、被認為在男激素性禿髮之病因上扮演重要角色。在日本專利JP-8 310923號中，用蒸氣蒸餾香橙（Citrus aurantiuai)皮、以及撒爾維亞（Salvia officinalis)、薄荷（Mentha piperita)、油加利（Eucaliptus globulus) 、艾屬（Artemisia princeps)及迷迭香（Rosmarinus officinalis)之葉子及花所得精油，被認為是睪固晒5 - oc -選原酶之抑狗劑而因此可有效治療禿髮、多毛症與脂漏症。歐洲專利EP-433 1 3 1 A揭示於存在有已知之血管擴張劑如菸鹼酸甲酯或其他合成化合物之脂性物質中加入精油， Μ預防掉髮或頭皮屑形成，及抗寄生蟲。這些精油之化學組成物未被報導，其效果似經由存在於最終調配物中之其他合成化合物來達成。現在發琨一些植物（單獨或組合）經由醇萃取繼而蒸餾所得到之單萜混合物出乎意料之外地顯示血管動力、抗菌與抗脂漏症活性。從精油已知之抗菌活性從未聯想到其具有顯著之血管動力活性，而該血管動力活性《3哨雷射都卜勒（ Laser Dopp Ur)技術及電腦影像微血管鏡檢法（computer videocapHlary-scopy)、測定於塗敷該混合物前、後，本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐）一 4 - (請先閱讀背面之注意事項再填寫本頁 4 訂經消部中戎標準局员T-消费合作社印則木 513306 A7 B7 五、發明説明（2 ) 被治療皮膚區域之血流控制來證明。簞β與已知可強力抑制環氧酶I與]I之柳酸κ及具有10 至14個碳原子（尤其是12個碳原子）之醜鐽之飽和及不飽和脂肪酸（如月桂酸及肉Μ蔻酸）之組合，特別顯示在治療一般狀況之掉髮及男性激素性禿髮上有效。單萜混合物可Μ 適當比例混合單一市售的單萜而獲得，或較佳藉下法得到 :胯|有至今尚未被用於化粧品Κ預防或治療掉髮之精油（迷迭香為例外，其曾被用於化粧品，不過作用機制與本發明所報告者不同）之一些產生六碳環（hexotic)之植物之***、根莖、葉、樹皮及種子予以混合，將該等物質浸漬於 70¾乙醇，最後在室壓下經蒸餾收集含有所欲單®之酒精。例如，精油之混合锪可藉由在7 0 S；醇水溶液內浸漬相似估量之根莖，該根莖係來自薑黃（Curcuma longa)、肉登競（Myristica fragrans)、阿魏（Ferula galbaniflua)、蘇合香（Liquidanbar orientalis)、山蘯（Alpinia officinartim)、水菖蒲（Acorus c a km u s )、蘆蒼（A 1 o e vera)、美人蕉（CannariuiB coaiune)、沒藥樹（Comifiiphora mo 1 mo 1) 、 T # (Eugenia aromat i ca) 、 (Cinnamonuffl Cassia)、鬱金屬（Curcuma zedoaria)、亞兒尼加（Arnica montana)、迷送香（Rosmarinus officinalis)及少量松節油，該植物性材料中各植物之含量為10克至50克，以20克為較佳，在室溫下將其在1 , 2升7 0 %之乙醇中攪拌二天，然後於室溫蒸餾_精並收集0.7至0.95升之蒸餾液，較佳為 0.85升；此蒸餾液用適當水分稀釋後，至多至50；U/w，並本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐）一 5 一 (請先閱讀背面之注意事項再填寫本頁)Member of the Bureau of Decision Standards of the Ministry of Economic Affairs_τconsuming cooperative cooperative printing f 513306 A7 B7 V. Description of the invention () The present invention provides a novel composition for preventing and treating hair loss, which is a combination of vascular dynamics, antibacterial and antiandrogenic active substances . From the literature K and from the cosmetics practice, we can know that the hair loss is caused by the negative effects of the reduction of the microcirculation around the inside of the "cap-shaped fascia", the change of the relationship with the bacterial community, and the change of local androgen metabolism. Androgen, especially the increased deposition of dihydroxy masks in the hair follicles, is thought to play an important role in the etiology of androgenic alopecia. In Japanese Patent JP-8 310923, Citrus aurantiuai peel, as well as Salvia officinalis, Mentha piperita, Eucaliptus globulus, Artemisia princeps are steam distilled. ) And rosemary (Rosmarinus officinalis) leaves and flowers are essential oils, which are considered to be dog inhibitors of 5-oc -selective proenzyme and therefore can be effective in treating baldness, hirsutism, and alopecia. European patent EP-433 1 3 1 A discloses the addition of essential oils to fatty substances with known vasodilators such as methyl nicotinate or other synthetic compounds, to prevent hair loss or dandruff formation, and to resist parasites. The chemical composition of these essential oils has not been reported, and their effects appear to be achieved through other synthetic compounds present in the final formulation. Monoterpenoid mixtures obtained from some plants (alone or in combination) by alcohol extraction and distillation are now showing unexpectedly vascular motility, antibacterial and antilipidemia activity. The known antibacterial activity of essential oils has never been associated with a significant vasodynamic activity, and the vasodynamic activity is "3 Laser Dopp Ur Technology and Computer Video Capsule-scopy" Measured before and after coating the mixture, the paper size applies the Chinese National Standard (CNS) A4 specification (210X 297 mm) 1 4-(Please read the precautions on the back before filling out this page 4 Rong Standard Bureau member T-Consumer Cooperative Seal Zemu 513306 A7 B7 V. Description of the invention (2) It is proved by blood flow control of the treated skin area. 箪 β and sialic acid known to strongly inhibit cyclooxygenase I and] I The combination of κ and ugly saturated and unsaturated fatty acids (such as lauric acid and myristic acid) with 10 to 14 carbon atoms (especially 12 carbon atoms), especially shown in the treatment of hair loss and men in general conditions It is effective on hormonal baldness. Monoterpene mixtures can be obtained by mixing a single commercially available monoterpene at an appropriate ratio, or preferably obtained by: 胯 | There is no essential oil that has not yet been used in cosmetics K to prevent or treat hair loss ( Rose Except for example, it has been used in cosmetics, but its mechanism of action is different from that reported by the present invention.) The roots, rhizomes, leaves, bark and seeds of some plants producing hexotic rings are mixed, and these substances are impregnated. At 70¾ ethanol, finally collect the alcohol containing the desired unit® by distillation under room pressure. For example, a mixture of essential oils can be obtained by impregnating a similarly sized rhizome in an aqueous solution of 70 S; alcohol, which is derived from turmeric (Curcuma longa), Myristica fragrans, Ferula galbaniflua, Liquidanbar orientalis, Alpinia officinartim, Acorus ca km us, A 1 oe vera, canna (CannariuiB coaiune), Myrrh (Comifiiphora mo 1 mo 1), T # (Eugenia aromat i ca), (Cinnamonuffl Cassia), Curcuma zedoaria, Arnica montana, Mixiangxiang ( Rosmarinus officinalis) and a small amount of turpentine, the content of each plant in the plant-based material is 10 to 50 grams, preferably 20 grams, at room temperature, it is 1-2 liters of 70% B Stir for two days, then distill at room temperature to collect and collect 0.7 to 0.95 liters of distillate, preferably 0.85 liters; this distillate is diluted with appropriate moisture to a maximum of 50; U / w, and this paper is suitable for China National Standard (CNS) A4 specification (210X 297 mm) 5 1 (Please read the precautions on the back before filling this page)

經滴部中决標準局员_τ消費合作社印f 513306 A7 _________ B7_____ 五、發明説明（3 ) 在移除不溶性油質殘渣後可用於抑制掉髮或作為加入其他活性成;分之基底。特佳者為將蒸餾所得之混合物，與柳酸及薄荷醇合併，以25至75 3： w/w之醇水溶液稀釋後，較佳最多至50¾，將其浸泡3至60天，較佳30天，並在移除不溶性油質殘渣後使用。本發明之第一目的為提供一種醇水性混合物，其含有做為主成分之点-蒎烯、崁烯、々-香葉烯、檸檬油精、按樹腦（1,8_環氧-P-薄荷烷）、崁酮、沈香醇、乙酸莰酯、乙酸異莰酯、薄荷醇、萜品烯醇、異茨醇，且各成份之比例如圖式之氣相層析圖譜所示。該層析圖譜係使用HP-Innoww 管（交聯之聚乙二醇，N. of part 19091 N-133, 30mx 0.25rom I.D.，0·25/χβι薄膜厚度），依照下列溫度處理方式而獲得：60°CX5分鐘，60£0至2501為3° /分鐘， 250 °C為3分鐘；用PTV (程式化溫度蒸發器）注射，由120°C 至2 50 °C。將柳酸或其鹽及具有抗雄性激素活性之脂肪酸加入混合物中造成驚人之增效作用，其可降低掉髮並促進頭髮生長與提高強度。因此，本發明之第二目的係一種調配物，其含有上述混合物與柳酸或其鹽及和飽和或不飽和 (：1〇-(：14脂肪酸之組合。根據本發明之一較佳具體例，精油之混合物得到係藉由浸漬2〇克之鬱金屦根莖、2〇克之肉登蔻種子、2〇克之桂樹枝樹皮、20克之丁香花、20克之水菖蒲根莖、20克之蘧根莖及20克之山薑於0*9升之乙醇内。一天後*阿魏之樹脂油、蘇合香、蘆薈、美人蕉、沒藥樹、亞兒尼加、迷迭香及 '本紙張尺度適用中國國家標準（CNS] A4規格（210X297公釐) ^ (請先閱讀背面之注意事項再填寫本頁)The member of the Standard Division of the Ministry of Economic Affairs, _τ Consumer Cooperative Co., Ltd. f 513306 A7 _________ B7_____ V. Description of the Invention (3) After removing the insoluble oily residue, it can be used to suppress hair loss or as a base for adding other active ingredients. Particularly preferred is a mixture obtained by distillation, combined with salicylic acid and menthol, and diluted with an aqueous alcohol solution of 25 to 75 3: w / w, preferably up to 50¾, and immersed for 3 to 60 days, preferably 30 And use after removing insoluble oily residue. A first object of the present invention is to provide an alcohol-based aqueous mixture, which contains dots as the main components-pinene, pinene, fluorene-geranene, lemon olein, and dendritic (1,8_epoxy-P -Mentane), fluorenone, linalool, ethyl acetate, isopropyl acetate, menthol, terpinenol, isozol, and the proportion of each component is shown in the gas chromatogram of the figure. The chromatogram was obtained using HP-Innoww tube (crosslinked polyethylene glycol, N. of part 19091 N-133, 30mx 0.25rom ID, 0.25 / χβι film thickness), and obtained according to the following temperature treatment: 60 ° C × 5 minutes, 60 ° 0 to 2501 is 3 ° / minute, 250 ° C is 3 minutes; injection with PTV (stylized temperature evaporator), from 120 ° C to 2 50 ° C. Adding salicylic acid or its salts and fatty acids with anti-androgenic activity to the mixture causes surprising synergistic effects, which can reduce hair loss and promote hair growth and increase strength. Therefore, a second object of the present invention is a formulation comprising the above mixture with a combination of salicylic acid or a salt thereof and a saturated or unsaturated (: 10-(: 14 fatty acid). According to a preferred embodiment of the present invention The essential oil mixture was obtained by impregnating 20 grams of turmeric rhizomes, 20 grams of nutmeg seeds, 20 grams of cinnamon bark, 20 grams of lilac flowers, 20 grams of calamus rhizomes, 20 grams of rhizomes and 20 grams of mountain. Ginger in 0 * 9 liters of ethanol. One day later * Awei ’s resin oil, savory, aloe, canna, myrrh, aronia, rosemary and 'This paper size applies to Chinese National Standard (CNS) A4 Specifications (210X297mm) ^ (Please read the precautions on the back before filling this page)

513306 A7 B7 五、發明説明（4 經滴部中央標準局員Η消费合作社印f 松節油加入浸漬產物中 f 其量可為5至50克， Μ促進樹脂油於酒; 精中之分散 0 之後，加入水至酒精濃度約 70%，而在40°C攪拌混合物二小時 9 開始蒸餾並收集約 0♦ 85升之酒精蒸餾液 0 該蒸餾液為無色純淨液體具有強烈芳香味。未加入其他物質之蒸餾液具有血管動力、抗菌及抗脂漏症之活性〇含單 m 之醇水性混合物在微血管層级可增加體積與流速 9 如上所述 9 此在原發及續發性禿髮上非常重要 0 實際上，當混合物被塗敷於皮虜上時 9 其整合不同器官區域之血流 9 尤其是增加 ”帽狀腱膜” 之血流，其結果如表 I 所報告之數據 9 其中流量之增加係用雷射都卜勒測試0 表 I 在單次塗敷 1 : :1 稀釋之酒精蒸餾液後， Μ 雷射都卜勒測得之皮膚血流變化〇物質 0 30 f 60 1 90 1 120，蒸餾液 4· 45 13 ♦ 33 14· 12 9,7 10.32 安慰劑 5 · 24 5. 63 7 ♦ 78 4.64 1 3*61 本發明配方施用之時間有從一週至 3個月之不同，如表 I 及 I 報告之數據所示 9 其在人體可使男性激素性禿髮顯著減少〇表 I 報告如雷射都卜勒分析所證明者，實 !施例 I組合物之施用造成血流增加。使用雷射都卜勒流: 動測定器來測試血管動力效果 > 其使用 per；F 1ι i X ( R ) 丨PF3流量計，其為可激發细小之 6 32r 丨®波長之單色光束之儀器 % 該: 祀係使用低能 He - f 丨e雷射源製造。藉此技術，測] 匱在基本狀態本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再填寫本頁)513306 A7 B7 V. Description of the invention (4 Printed by the Central Standards Bureau of the Ministry of Consumers, Consumer Cooperatives, turpentine added to the impregnated product, f The amount can be 5 to 50 grams, Μ promotes the dispersion of resin oil in wine; after the dispersion of 0 in the essence, add Water to an alcohol concentration of about 70%, and stir the mixture at 40 ° C for two hours. 9 Start distillation and collect about 0. 85 liters of alcohol distillate. 0 The distillate is a colorless, pure liquid with a strong aroma. Distillation without the addition of other substances The liquid has vascular dynamics, antibacterial and antilipidemia activity. The alcohol-containing aqueous mixture containing a single m can increase volume and flow rate at the microvascular level 9 as described above 9 This is very important in primary and secondary alopecia 0 Actual On the other hand, when the mixture is applied on the skin, 9 it integrates the blood flow of different organ regions 9 especially increases the blood flow of the “cap-shaped fascia”. The results are shown in Table I. 9 Laser Doppler Test 0 Table I Changes in skin blood flow measured by Laser Doppler after a single application of 1:: 1 diluted alcohol distillate. Substance 0 30 f 60 1 90 1 120, distillate 4.45 13 ♦ 33 14 · 12 9,7 10.32 placebo 5 · 24 5. 63 7 ♦ 78 4.64 1 3 * 61 The time of administration of the formulation of the present invention varies from one week to three months, such as The data reported in Tables I and I show 9 that they can significantly reduce male hormonal alopecia in humans. Table I reports that as demonstrated by laser doppler analysis, in fact, the application of the composition of Example I resulted in increased blood flow. .Using a laser Doppler flow: dynamic measuring device to test the vascular dynamic effect > It uses a Perimeter X (R) 丨 PF3 flowmeter, which is a monochromatic light beam that can excite a small 6 32r 丨 ® wavelength % Of equipment: The sacrifice is made with a low-energy He-f 丨 e laser source. With this technology, the measurement] is in the basic state. The paper size applies the Chinese National Standard (CNS) A4 specification (210X 297 mm) (Please read the precautions on the back before filling this page)

7 一 513306 經滴部中决標率局员_τ消費合作社印f A7 B77 a 513306 Member of the Bureau of Final Awards in the Ministry of Economics _τConsumer Cooperative Press f A7 B7

五、發明説明（S 及塗敷測試產品後之頭皮血流；於第一次塗敷後每1 5分鐘測量一次，Μ觀察急性作用K及在治療30、60、及90天後測量，Μ觀察慢性作用。結果被報告於表Ε 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再填寫本頁)V. Description of the invention (S and scalp blood flow after application of test product; measured every 15 minutes after the first application, M observed acute effects K and measured after 30, 60, and 90 days of treatment, M Observe the chronic effects. The results are reported in Table E. The paper size applies the Chinese National Standard (CNS) A4 specification (210X 297 mm) (Please read the precautions on the back before filling this page)

8 513306 A7 B7 五、發明説明（6 £68 513306 A7 B7 V. Description of the invention (6 £ 6

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❖ ί , ε+ιο ♦寸egr ΐ+ιΟ.ΟΙ * ο · ε+ιί,COCNJ 0 ΐ · ϊ+ιε · 6 00 ^ 0 51+lt+ 6 觀你 0二+|尸6 饜騸滌ϋ敷 £δκ·?·ιβ_ϊο·ο>α=* 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 9 經满部中决標準局負Η消費合作社印紫 513306 A7 B7 五、發明説明（7 ) 使用測試體之毛髮紀錄任意分成1 0組來計算在治療之開始與終止（90天）時配方在掉髮抑制上之效果。毛髮紀錄包含從額高及頸外側區域用橡皮鑷子拔除適當數目（約50)之頭髮。顯微檢查髮根K計算在生長期（生長）、退化期（成熟）及靜止期（靜止）之毛髮數量。生長期比例之降低與靜止期比例相對於正常值之增加（各約85〜90¾及10-15¾)代表致病性掉髮之臨床證據。本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再填寫本頁)❖ ί, ε + ιο ♦ inch egr ΐ + ιΟ.ΟΙ * ο · ε + ιί, COCNJ 0 ΐ · ϊ + ιε · 6 00 ^ 0 51 + lt + 6 Watch you 0 二 + | £ δκ ·? · Ιβ_ϊο · ο > α = * This paper size is applicable to Chinese National Standard (CNS) A4 (210X297 mm). (7) Use the test subject's hair record to arbitrarily divide into 10 groups to calculate the effect of formula on hair loss suppression at the beginning and end of treatment (90 days). The hair record contains a suitable amount (approximately 50) of hair removed from the forehead and the outer area of the neck with rubber tweezers. Microscopic examination of the hair root K counts the number of hairs during the growth (growth), degeneration (maturity), and quiescence (still) periods. The decrease in the growth phase ratio and the increase in the stationary phase ratio relative to normal values (approximately 85 ~ 90¾ and 10-15¾ each) represent clinical evidence of pathogenic hair loss. This paper size applies to China National Standard (CNS) A4 (210X 297 mm) (Please read the precautions on the back before filling this page)

513306 A7 B7 五、發明説明（8) 經消部中次標準局員T-消費合作社印f 表 I 局部塗敷簧施例 I製備之洗劑 (歷90日）所引起之毛效應 0 治療毛髮紀錄（％ - m 士 e * s .) 靜止期生長期+退化期麵精蒸餾液之前 76 士 3 24 土 1 90天後 81 土 3 19 士 1 酒精蒸餾液+ 之前 78 士 2 22 士 1 柳酸 90天後 82 土 2 18 士 1 柳酸 +蒸餾液之前 74 土 2 26 士 2 柳酸 +脂肪 90天後 86 土 3吞 14 土 1容 ^ = p < 0,01 vs基值*為計算之結果 (請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 11 513306 A7 B7 五、發明説明（9) 從上報告之數據可看出，長期每日局部塗敷該酒精蒸鑛液在皮虜上可發揮持久，有利之微血管動力效應。對於毛髮參數，靜止期、生長期與退化期亦有相似之效應。其他物質如低分子量飽和及不飽和脂肪酸（其可干擾雄性激素受器）與該蒸餾液併用，導致靜止期一生長期一退化期比例之明顯改善。藉由增加血流及後續營養物之增加之皮虜治療，在數天後造成表皮明顯改II灌血之微血管數目增加及頭皮屑消失髮囊為正常且明顯，並具正常皮脂製造。本發明之化粧組合物係做成醇水性洗劑（適用於治療禿頭）或凝膠形式，並用於治療掉髮及脂漏症。治療較佳使用之組成含有濃度在5〜201之醇水混合物，較佳10¾，脂肪酸介於0.1及0.5¾間，較佳0.25¾，而柳酸介於0 . 1及1 %間，較佳0 . 3 。這些物質之治療可從數天至6個月。本發明之組合物實例例示性逑於此，但並非囿限本發明。實施例I -製備具有高含量精油之蒸餾液，其可做為治療禿頭之化粧組合物之基底。在2升之燒瓶内裝入0.9升之乙醇及加入20克之鬱金羼根莖，20g之肉登蔻種子、20克之桂分支樹皮、20克丁香花、20克之水菖蒲根莖、20克之薑根莖及20克之山蓳（剁细）來攪拌並浸漬一天。10克之阿魏、蘇合香、美人蕉、沒藥樹、迷送香樹脂油加入浸漬產物中但不移去植物材料；再者，加入20克之松節油Μ加速樹脂油於酒精中之散布。在二天之浸漬後，加入水至酒精濃度約70¾並在40 °C攪拌混本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐）一 12 (請先閱讀背面之注意事項再填寫本頁)513306 A7 B7 V. Description of the invention (8) Printed by T-Consumer Cooperative, Member of the Intermediate Standards Bureau of the Ministry of Economic Affairs f Table I Hair effect caused by the application of the lotion prepared in Example I (for 90 days) 0 Treatment hair record (%-M ± e * s.) During the stationary phase growth period + degraded period before the distillate distillate 76 ± 3 24 soil 1 after 90 days 81 soil 3 19 ± 1 alcohol distillate + before 78 ± 2 22 ± 1 salicylic acid After 90 days 82 soil 2 18 ± 1 salicylic acid + before distillate 74 soil 2 26 ± 2 salicylic acid + fat 90 days later 86 soil 3 swallow 14 soil 1 volume ^ = p < 0,01 vs base value * is calculated Results (Please read the notes on the back before filling this page) This paper size is applicable to Chinese National Standard (CNS) A4 specification (210X 297 mm) 11 513306 A7 B7 V. Description of the invention (9) The data reported from the above can be It can be seen that long-term daily topical application of the alcohol-steamed mineral liquid can exert long-lasting and favorable microvascular dynamic effects on the skin. Regarding hair parameters, the quiescent period, growth period, and degradation period also have similar effects. Other substances such as low-molecular-weight saturated and unsaturated fatty acids (which can interfere with the androgen receptor) are used in combination with this distillate, resulting in a marked improvement in the ratio of the stationary phase to the growth phase and the degradation phase. With the skin-pump treatment that increased blood flow and subsequent nutrient increase, the number of microvessels in the epidermis changed significantly after a few days, and dandruff disappeared. The hair follicles were normal and obvious, with normal sebum production. The cosmetic composition of the present invention is made into an alcohol-based lotion (suitable for treating baldness) or a gel form, and is used for treating hair loss and alopecia. The composition preferably used for treatment contains an alcohol-water mixture with a concentration of 5 ~ 201, preferably 10¾, fatty acids between 0.1 and 0.5¾, preferably 0.25¾, and salicylic acid between 0.1 and 1%, preferably 0. 3. The treatment of these substances can be from several days to 6 months. Examples of the composition of the present invention are exemplified here, but the present invention is not limited thereto. Example I-Preparation of a distillate with a high content of essential oils, which can be used as a base for a cosmetic composition for treating baldness. Fill a 2-liter flask with 0.9 liters of ethanol and add 20 grams of turmeric root rhizomes, 20 g of nutmeg seeds, 20 grams of cinnamon bark, 20 grams of lilac flowers, 20 grams of calamus rhizomes, 20 grams of ginger rhizomes and 20 Kezhi Mandrill (chopped finely) to stir and soak for a day. 10 grams of ferulic acid, sesame, cannabis, myrrh, and fragrant resin oil were added to the impregnated product without removing plant material; further, 20 grams of turpentine M was added to accelerate the dispersion of the resin oil in alcohol. After two days of immersion, add water to an alcohol concentration of about 70¾ and stir and mix at 40 ° C. The paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm). 12 (Please read the precautions on the back before filling in this page)

、1T 經满部中决標準局員,τ消贽合作社印則木 513306 A7 B7 五、發明説明（10 ) 合物二小時後開始於室溫蒸餾，並收集0.85升之酒精蒸織液。蒸餾液含有圖式之氣相層析圖譜所示比例之点-練烯、崁烯、召-香葉烯、檸檬油精、桉樹腦（1,8-環氧-對-薄荷烷）、崁嗣、沈I醇、乙酸莰酯、乙酸異莰酯、薄荷醇、萜品烯醇、異茨醇。實施例H 含有精油、柳酸、月桂酸之洗劑 1 0 0克之洗劑含： 21克實施例I之蒸餾液 (K3克柳酸 0.2克月桂酸 6.9克迷送香精油 0.79克潘打唑（Pantasol) 1 . 1 8克薄荷醇 34克 Rhum之芳香化酒精去離子水<?.s.至100克實施例Μ 含有精痛、月桂酸、四聚環矽氧烷與五聚環矽氧烷之80 : 20混合物之洗劑 100克洗劑含： 2 1克實施例I之精油蒸餾液 0.2克月桂酸 0.08克崁_ 15克四聚與五聚體環矽氧烷之80: 20混合物 1 . 1 8克薄荷醇 95¾乙醇及水Μ得到50¾酒精濃度，加足量至ΙΟΟηιΙ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐）一 1 3 - (請先閱讀背面之注意事項再填寫本頁)1T, member of the Bureau of Standards for Mandatory Decisions, Yin Zemu of τ Consumer Cooperative Co., Ltd. 513306 A7 B7 5. Description of the Invention (10) The compound was distilled at room temperature two hours later, and 0.85 liters of alcohol-distilled liquid was collected. The distillate contains points of the proportions shown in the gas chromatogram of the figure-linene, pinene, callo-geranene, lemon olein, eucalyptus brain (1,8-epoxy-p-menthane), hydrazone Samarium, Shen I alcohol, ethyl acetate, isopropyl acetate, menthol, terpinenol, isotrol. Example H 100 g of lotion containing essential oil, salicylic acid, and lauric acid: 21 g of the distillate of Example I (K3 g of salicylic acid 0.2 g of lauric acid 6.9 g of fan essential oil 0.79 g of pantalazole (Pantasol) 1. 18 grams of menthol 34 grams of Rhum's aromatized alcohol deionized water <?. S. To 100 grams Example M contains essence pain, lauric acid, tetrapolycyclosiloxane and pentacyclosiloxane Lotion of 80:20 mixture of 100 grams of lotion contains: 2 1 grams of the essential oil distillate of Example I 0.2 grams of lauric acid 0.08 grams 崁 15 grams of tetrameric and pentameric cyclosiloxanes 80: 20 Mixture 1.1. 8 grams of menthol 95¾ ethanol and water Μ to obtain 50¾ alcohol concentration, add enough to ΙΟΟηιΙ This paper size applies the Chinese National Standard (CNS) A4 specification (210X 297 mm)-1 3-(Please read the back first (Notes for filling in this page)

513306513306

本硏究是以20位年齡介於20歲至46歲之間具有雄性禿⑼妨c 的志願測試者進行。藥劑的使用量爲每15天有一天使用一次以及每19 週有一週使用2次，整個硏究持續90天。於治療進行的起始(t〇)、過45天(t45)以及最後(t90)階段’皆由一位臨床醫師執行以下的儀器及皮膚分析： (1) 拉扯測試(評估掉髮與耐拉扯性，參見表1); (2) 以皮脂檢測帶(Sebutape)評估皮脂分泌狀況(脂漏症存在與否），該皮脂檢測帶係一種可檢S11包含前額與頭皮之間區域的皮脂分泌量和分布情況的黏性皮脂感測膜(參見表1和2); (3) 頭皮屑和紅斑(參見表2，客觀評估）。志願測試者本身的主觀評估亦以同樣的時間間隔檢視以下特徵:脂漏症的存在、頭皮屑和頭皮紅斑的存在、頭皮检(scalp hitching)、靜電、梳理的流暢度、以及頭髮的明亮度(表3) 〇表1之資料顯示藥劑增加了頭髮的耐拉扯性，減少掉髮情況(-58.4%)，並降低了頭皮上的皮脂分泌量(-11.86%)。至於客觀評估，已觀察到其減輕了脂漏症、稍微減輕頭皮屑以及減少頭皮紅斑等症狀(表2)〇主觀評估亦顯示本藥劑的功效，事實上，也已觀察到其減輕了脂漏症、頭皮屑和頭皮栓等症狀，稍微減少頭皮紅斑和頭髮靜電，並增加了頭髮的明亮度且容易梳理(表3) 〇 ti9 0071050-5/7^-會賓架 * 再奮杳11¾由害表1 :儀器分析拉扯測試皮脂檢測帶1 受測者 to t45 t90 to t45 t90 1 2 3 1 4 3 3 2 2 1 0 4 3 3 3 12 7 4 2 2 2 4 15 9 7 2 2 2 5 2 0 0 2 2 2 6 5 3 0 4 3 3 7 7 5 5 5 4 3 8 9 11 6 2 2 2 9 2 0 0 3 3 3 10 5 4 2 3 3 3 11 4 6 4 2 2 2 12 1 2 0 4 4 4 13 0 2 0 2 2 2 14 3 5 3 3 3 3 15 5 3 0 2 2 2 16 3 0 0 4 3 3 17 2 0 0 2 2 2 18 4 2 4 2 2 2 19 5 3 1 3 3 3 20 1 0 0 4 3 3 平均 4.45 3.30 1.85 2.95 2.65 2.60 標準差 ±3.804 ±3.113 ±2.345 ±0.998 ±0.670 ±0.598 t0->t90 p<0.05 t0—190 ρ0·05 513306 1 皮脂分布參考尺度〇=無 1 =少許 2-3 =正常 4=高 5 =非常高表2 :客觀評估受測者脂漏症之存在W 頭皮屑1 頭皮紅斑1 to t45 t90 to t45 t90 to t45 t90 1 2 1 1 2 1 1 1 0 0 2 2 0 0 1 1 1 0 0 0 3 0 0 0 0 0 0 0 0 0 4 0 0 0 1 1 1 1 0 0 5 2 1 1 2 2 2 1 0 0 6 3 2 2 2 2 2 2 1 1 7 0 0 0 0 0 0 0 0 0 8 0 0 0 1 1 1 0 0 0 9 1 1 1 2 1 1 1 1 0 10 0 0 0 0 0 0 0 0 0 11 2 1 1 2 1 1 1 0 0 12 0 0 0 2 1 1 0 0 0 13 1 1 1 2 1 1 1 1 1 14 0 0 0 0 0 0 0 0 0 15 2 1 1 2 2 2 2 1 1 16 0 0 0 0 0 0 0 0 0 17 0 0 0 1 1 1 0 0 0 18 0 0 0 0 0 0 0 0 0 19 1 1 1 1 1 1 1 0 0 20 2 1 1 2 2 2 1 0 0 平均 0.90 0.50 0.50 1.15 0.90 0.90 0.60 0.20 0.15 513306 1 評估尺度〇=無 1 =輕微 2 =中等 3 =嚴重 513306 担紘鼷州：e« 明亮度(2) 〇 ON <Ν (Ν (Ν (Ν <Ν (Ν (Ν <Ν (Ν (Ν (Ν (Ν (Ν <Ν 一 (Ν rs 一〇〇 <Ν CN (Ν (Ν CN (Ν 一 (Ν (Ν (Ν ^Η — 一 (Ν (Ν — (Ν »"·Η — VO 〇 — <Ν — 一 <Ν ο Ο — (Ν r—ί f-Η — 一 (Ν 一 — ΓΝ 一 CO 梳理容易度(2) 〇 σ\ CN <Ν (Ν (Ν Ο Η (Ν CN (Ν (Ν (Ν (Ν (Ν (Ν CN (Ν CN (Ν CN (N un 〇〇 3 <Ν (Ν (Ν <Ν ο «ΜΜ^ — (Ν (Ν (Ν CN (Ν (Ν (Ν (Ν (Ν (Ν CN (N 1.75 ο (Ν <Ν (Ν (Ν — ο ο 一 <Ν (Ν <Ν (Ν (Ν (Ν CN ν—( (Ν (Ν (N (N v〇頭髮靜電(|) ο a ψ^4 Ο — CN ο Ο Ο Ο 一 ο 一 ο 一 ο ο ο — — 0.55 Ο — <Ν ο Ο Ο Ο r—^ 一 ο 一 ο 一 ο ο ο 一 — 0.55 ο (Ν (Ν (Ν ο ν—< ο ο <Ν (Ν ο 一 ο (Ν ο ο CN 一 p 頭皮栓(1) ο Ο Ο Ο Ο ο ο Ο ο 一 ο 一 <Ν ο ο ο ο ο O — m 艺 Ο ο Ο Ο ο ο ο ο 一 ο 一 rs ο ο ο ο ο o 一 m O ο 一 ο Ο ο ο <Ν ο r—Ή 一 ο <Ν CM ψ '" < ο ο ο ο 一一 (N 卜 o 頭皮紅斑(1) ο 〇\ Ο ο ο ο ο ι-Η ο ο ο ο ο ο Ο ο Η ο ο ο o 〇 5 ο ο ο ο ο ο ο ο ο ο ο Ο ο »—Η ο ο ο o 〇 5 Ο ο ο ο ο ο (Ν ο ο 一 ο ο ο Ο ο (Ν ο ο ο 一 — 0.35 頭皮屑(1) ο σ\ ο ο (Ν CS ο ο ο (Ν 一 ο (Ν ο 一 (N On 〇 •Ti ο ο <Ν (Ν ο • ·4 — ο r-H (Ν ο <Ν ο 一 (N 〇 ο (Ν ο 9 ' i m ο ^-Η (Ν ο (Ν (Ν ο (Ν ο — (Ν (N 脂漏症之存在(|) ο Os Ο Ο ο ο 1'''< ο Ο Ο ο 一 ο Ο ο Ο ο ο 一一 — rn o 艺 Ο Ο ο ο ψ·· i (Ν ο Ο ο ο — ο Ο ο — ο ο τ·Η 一一寸 o ο (Ν (Ν ο ο (Ν Γ〇 r-H Ο ο (Ν ο Ψ—Η ο (Ν ο ο r—< — (N p 受測者一 <Ν m 寸 νο 卜 00 σ\ ο (Ν ΓΟ 2 卜 00 ON 平均 &驶# = e § = i _豳=e Sri 上 t Ho 撇 Φ=<Ν« HoThis study was performed with 20 volunteer testers with male vultures c between 20 and 46 years of age. The dosage of the medicament was once every 15 days and twice a week every 19 weeks, and the whole study lasted 90 days. The following instruments and skin analysis were performed by a clinician at the beginning (t0), 45 days (t45), and the last (t90) of the treatment: (1) Pull test (evaluation of hair loss and resistance to pull) (See Table 1); (2) Assessing sebum secretion (seborrhea) with a sebum test strip (seborrhea), which is a detectable S11 sebum secretion in the area between the forehead and the scalp Volume and distribution of adhesive sebum sensing membranes (see Tables 1 and 2); (3) dandruff and erythema (see Table 2, objective assessment). The subjective assessment of the volunteer testers themselves also examined the following characteristics at the same time intervals: the presence of lipid leaks, the presence of dandruff and scalp erythema, scalp hitching, static electricity, smoothness of combing, and hair brightness (Table 3) 〇 The information in Table 1 shows that the drug increases the pull resistance of the hair, reduces hair loss (-58.4%), and reduces the amount of sebum secretion (-11.86%) on the scalp. As for the objective evaluation, it has been observed to reduce the symptoms of adiposity, slightly reduce dandruff, and reduce erythema of the scalp (Table 2). The subjective evaluation also shows the efficacy of this agent, and in fact, it has also been observed to reduce adiposity Symptoms, dandruff, and scalp plugs, slightly reduce scalp erythema and hair static, and increase hair brightness and ease combing (Table 3) 〇ti9 0071050-5 / 7 ^ -Visiting frame Damage Table 1: Instrument Analysis Pull Test Sebum Test Strip 1 Subject to t45 t90 to t45 t90 1 2 3 1 4 3 3 2 2 1 0 4 3 3 3 12 7 4 2 2 2 15 15 7 7 2 2 2 5 2 0 0 2 2 2 6 5 3 0 4 3 3 7 7 5 5 5 4 3 8 9 11 6 2 2 2 9 2 0 0 3 3 3 10 5 4 2 3 3 3 11 4 6 4 2 2 2 12 1 2 0 4 4 4 13 0 2 0 2 2 2 14 3 5 3 3 3 3 15 5 3 0 2 2 2 16 3 0 0 4 3 3 17 2 0 0 2 2 2 18 4 2 4 2 2 2 19 5 3 1 3 3 3 20 1 0 0 4 3 3 Mean 4.45 3.30 1.85 2.95 2.65 2.60 Standard deviation ± 3.804 ± 3.113 ± 2.345 ± 0.998 ± 0.670 ± 0.598 t0- &t; t90 p < 0.05 t0-190 ρ0 · 05 513306 1 Sebum distribution Reference scale 0 = None 1 = A little 2-3 = Normal 4 = High 5 = Very high Table 2: Objective assessment of the presence of lipid leak in the subject W Dandruff 1 Scalp on the scalp 1 to t45 t90 to t45 t90 to t45 t90 1 2 1 1 2 1 1 1 0 0 2 2 0 0 1 1 1 0 0 0 3 0 0 0 0 0 0 0 0 4 0 0 0 1 1 1 1 0 0 5 2 1 1 2 2 2 1 0 0 6 3 2 2 2 2 2 2 1 1 7 0 0 0 0 0 0 0 0 0 8 0 0 0 1 1 1 0 0 0 9 1 1 1 1 2 1 1 1 1 0 10 0 0 0 0 0 0 0 0 0 11 2 1 1 2 1 1 1 0 0 12 0 0 0 2 1 1 0 0 0 13 1 1 1 2 1 1 1 1 1 14 0 0 0 0 0 0 0 0 0 15 2 1 1 2 2 2 2 1 1 16 0 0 0 0 0 0 0 0 0 17 0 0 0 1 1 1 0 0 0 18 0 0 0 0 0 0 0 0 0 19 1 1 1 1 1 1 1 0 0 20 2 1 1 2 2 2 1 0 0 0.90 0.50 0.50 1.15 0.90 0.90 0.60 0.20 0.15 513306 1 1 = Minor 2 = Moderate 3 = Severe 513306 Danzhou: e «Brightness (2) 〇 ON < Ν (Ν (Ν (Ν < Ν (Ν (Ν < Ν (Ν (Ν (Ν (Ν ( Ν (Ν < Ν-(N rs-100) < NH CN (N (N CN (N (N (N (N ^^ —-(N (N — (N »" ··-VO 〇〇 — &Lt; Ν — one < Ν ο Ο — (Ν r—ί f-Η — one (Ν 一 — ΓΝ—CO combing is easy (2) 〇σ \ CN < N (N (Ν Ο Η (Ν CN (Ν (Ν (Ν (Ν (Ν CN (Ν CN (ΝCN (N un 〇〇3 < Ν ( Ν < Ν ο «ΜΜ ^ — (Ν (Ν (Ν (Ν CN (Ν (Ν (Ν (Ν (Ν CN (N 1.75 ο (Ν < Ν (Ν (Ν — ο ο a) < Ν ( Ν < Ν (Ν (Ν (ΝCN ν— ((Ν (Ν (N (N v〇hair static electricity (|) ο a ψ ^ 4 Ο — CN ο Ο Ο Ο Ο ο ο ο ο ο — — 0.55 Ο — < Ν ο Ο Ο Ο r— ^ one ο one ο ο ο ο one — 0.55 ο (Ν (Ν (Ν (Ν ο ν-< ο ο) < Ν (Ν ο ο ο Ν ο ο CN Onep Scalp Plug (1) ο Ο Ο Ο Ο ο ο Ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο ο o one m O ο one ο Ο ο ο < Ν ο r—Ή one ο < Ν CM ψ '" < ο ο ο ο one one (N bu o scalp erythema (1) ο 〇 \ ο ο ο ο ο ι-Η ο ο ο ο ο ο ο ο ο ο ο o 〇5 ο ο ο ο ο ο ο ο ο ο ο Ο ο »—Η ο ο ο o 〇 5 Ο ο ο ο ο ο ο ο ο a ο ο ο Ο ο (Ν ο ο ο One — 0.35 Dandruff (1) ο σ \ ο ο (Ν CS ο ο ο (Ν aο (Ν ο 一 (N On 〇 • Ti ο ο < Ν (Ν ο • · 4 — ο rH (Ν ο < Ν ο 一 (N οο (Ν ο 9 'im ο ^ -Η (Ν ο (Ν (Ν ο (Ν ο — (Ν (N Lipidosis) (|) ο Os Ο Ο ο ο 1 '' '< ο Ο Ο ο ο ο ο Ο ο ο one one — rn o 艺 Ο Ο ο ο ψ ·· i (Ν ο Ο ο ο — ο ο ο ο ο τ · Η one inch o ο (Ν (Ν ο ο (Ν Γ〇rH Ο ο (Ν ο Ψ—Η ο (Ν ο ο r— < — (N p subject 1) < N m inch νο BU 00 σ \ ο (Ν ο ΓΟ 2 Bu 00 ON average & driving # = e § = i _ 豳 = e Sri on t Ho Φ = < Ν «Ho

Claims

513306 Αδ Β8 C8 D8 外％靡 ^ n U . 修正赛六、申請專利範圍 1 . 一種用於製備在治療掉髮及脂漏症上有用之化粧品配方的組合物，包含有0.1至1%之柳酸、0.1至〇.5%之Go-Cm 飽和或不飽和脂肪酸及5至20%之醇水性混合物，該醇水性混合物係萃取自鬱金屬（Curcuma zedoari a)、肉宣蔻 (Myristica fragrans)、桂（Cinnamonum cassia)、丁香 (Eugenia aromatica)、水菖蒲（Acorus calamus)、薑 (Zingiber officinalis)、山薑（Alpinia officinar um)、 .阿魏（Ferula galbaniflua)、蘇合香（Liquidamba ιοί-ientalis) 、蘆薈（Aloe ver a) 、美人蕉（Can narium comu n e)、沒藥樹（Commiphora molmol)、亞兒尼加（Arnica mo n tan a)、迷迭香（Rosmarinus officinalis)之精油，該精油含有θ -蒎烯、崁烯、/3 -香葉烯、檸檬油精、桉樹腦 (1，8-環氧-對-薄荷烷）、崁酮、沈香醇、乙酸莰酯、乙酸異莰酯、薄荷醇、萜品烯醇、異茨醇單萜，具有圖1所示之層析圖譜。 2 ·如申請專利範圍第1項之組合物，其中，該混合物濃度爲10%，該柳酸濃度爲0.3%，該脂肪酸濃度爲〇.2 5%。 3 · —種化粧組合物，其含有申請專利範圍第1或2項之組合物，並與醫藥上可接受載劑及賦形劑混合。 4 .如申請專利範圍第3項之組合物，其係爲醇水性洗劑或凝膠形式。 5 . —種製備申請專利範圍第1項之組合物之方法，包含有： a)將一份或一份以上選自鬱金屬（Curcuma zedoaria)、肉本紙張尺度適用中國國家標準（cns)a4規格（21〇χ 297公釐） —f—----------------訂---------線 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 513306 Αδ Β8 C8 D8 六、申請專利範圍宣蔻（Myristica fragrans)、® (Cinnamonum cassia)、丁香（Eugenia aromatica)、7_K 菖蒲（Aeons calamus)、薑 (Zingiber officinalis)、山薑（Alpinia officinarum) ' 阿魏（Ferula galbaniflua)、蘇合香（Liquidamba ιοί-ientalis) 、蘆薈（Aloe v e r a )、美人蕉（Cannarium comune)、沒藥樹（Commiphora molmol)、亞兒尼加（Arnica montana)、迷迭香（Rosmarinus officinalis)之根、根莖、葉、樹皮及種子，連同松節油，在室溫及攪拌下浸漬於70% 乙醇中歷時二天，然後置於40 °C中2小時； b)於室壓及40°C下蒸餾a)之產物； c )以水稀釋b )之蒸餾液並移除不溶性油質殘渣；以及 d)加入柳酸及脂肪酸。 6 .如申請專利範圍第5項之方法，其中，植物或其部分之用量爲每種植物使用10克至50克。 7 .如申請專利範圍第6項之方法，其中，每種植物之用量爲20克。 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製本紙張尺度適用中國國家標準（CNS)A4規格（21〇 χ 297公釐）513306 Αδ Β8 C8 D8 %% U ^. U. Amendment Match VI. Application for Patent Scope 1. A composition for preparing a cosmetic formula useful in treating hair loss and adiposity, containing 0.1 to 1% willow Acid, 0.1 to 0.5% Go-Cm saturated or unsaturated fatty acids, and 5 to 20% alcohol-water mixture, the alcohol-water mixture is extracted from Curcuma zedoari a, Myristica fragrans, Cinnamonum cassia, Eugenia aromatica, Acorus calamus, Zingiber officinalis, Alpinia officinar um, Ferula galbaniflua, Liquidamba ιοί-ientalis, Aloe (Aloe ver a), Canna (Can narium comu ne), Myrrh tree (Commiphora molmol), Arnica (Arnica mo n tan a), Rosemary (Rosmarinus officinalis) essential oil, this oil contains θ-蒎Ene, pinene, / 3-geranene, lemon olein, eucalyptol (1,8-epoxy-p-menthane), fluorenone, linalool, ethyl acetate, isopropyl acetate, menthol, Terpinenol, isotrol monoterpene, It has the chromatogram shown in Figure 1. 2. The composition according to item 1 of the scope of patent application, wherein the concentration of the mixture is 10%, the concentration of salicylic acid is 0.3%, and the concentration of fatty acids is 0.25%. 3. A cosmetic composition, which contains the composition of claim 1 or 2, and is mixed with a pharmaceutically acceptable carrier and an excipient. 4. The composition according to item 3 of the patent application, which is in the form of an alcohol-based lotion or gel. 5. — A method for preparing the composition of the scope of application for patent application item 1, including: a) One or more selected from the group consisting of Curcuma zedoaria and fleshy paper; Chinese national standard (cns) a4 applies Specifications (21〇χ 297 mm) —f —---------------- Order --------- line (Please read the precautions on the back before filling in this Page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 513306 Αδ Β8 C8 D8 VI. Patent application scope Myristica fragrans, ® (Cinnamonum cassia), Eugenia aromatica, 7_K Aeons calamus, ginger ( Zingiber officinalis, Alpinia officinarum '' Ferula galbaniflua, Liquidamba ιοί-ientalis, Aloe vera, Canna (Cannarium comune), Commiphora molmol, Arnica (Arnica montana), Rosmarinus officinalis (Rosmarinus officinalis) roots, rhizomes, leaves, bark and seeds, together with turpentine, immersed in 70% ethanol for two days at room temperature and stirring, and then placed at 40 ° C for 2 hours B) at room pressure Distillation under a 40 ° C) of product; c) was diluted with water b) the distillate is removed and the insoluble oily residue; and d) addition of a fatty acid and salicylic acid. 6. The method of claim 5 in which the amount of the plant or part thereof is 10 to 50 grams per plant. 7. The method of claim 6 in which the amount of each plant is 20 grams. (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs This paper is sized to the Chinese National Standard (CNS) A4 (21 × 297 mm)