TW202233155A - Wipe sheet and aqueous composition for impregnating wipe sheet - Google Patents

Wipe sheet and aqueous composition for impregnating wipe sheet Download PDF

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TW202233155A
TW202233155A TW111106494A TW111106494A TW202233155A TW 202233155 A TW202233155 A TW 202233155A TW 111106494 A TW111106494 A TW 111106494A TW 111106494 A TW111106494 A TW 111106494A TW 202233155 A TW202233155 A TW 202233155A
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water
mass
content
based composition
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TW111106494A
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石井和親
磯川由美
金尾彌生
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日商麗固股份有限公司
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/06—Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47K—SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
    • A47K7/00—Body washing or cleaning implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
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  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Toxicology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Provided are a wipe sheet having high storage stability and reduced skin irritation, and an aqueous composition for impregnating a wipe sheet. This wipe sheet comprises a base sheet that is formed of a woven or non-woven fabric and impregnated with an aqueous composition, wherein the aqueous composition contains, in purified water, 0.030-0.050 mass% inclusive of a benzalkonium chloride, 0.025-0.070 mass% inclusive of polyaminopropyl biguanide hydrochloride and 0.003-0.050 mass% inclusive of glyceryl caprate, each as a storage enhancer, and a solvent as a solubilizer for solubilizing glyceryl caprate, and the concentration of the purified water in the aqueous composition is 99.85-99.92-mass% inclusive.

Description

擦拭片、及擦拭片含浸用之水系組成物Wiping sheet and water-based composition for impregnating the wiping sheet

本發明係關於基材片中含浸有包含保存性提升劑與助溶劑的水系組成物之擦拭片、及該擦拭片含浸用之水系組成物。The present invention relates to a wiping sheet in which a substrate sheet is impregnated with an aqueous composition containing a preservative enhancer and a cosolvent, and an aqueous composition for impregnating the wiping sheet.

以往，為了在嬰幼兒、被看護者的一次性尿布等的交換時容易擦掉污垢、或為了擦拭附著有污垢的手、身體而使用了濕式的擦拭片。濕式的擦拭片通常係將純化水中包含抗菌劑等的水系組成物含浸於基材片而製作。Conventionally, wet wiping sheets have been used in order to easily wipe off dirt when changing disposable diapers of infants and care recipients, or to wipe off dirty hands or bodies. A wet wipe sheet is usually produced by impregnating a base sheet with an aqueous composition containing an antibacterial agent or the like in purified water.

為了減低對於肌膚的刺激，前述水系組成物希望在純化水中的抗菌劑等的含量少。特別是使用於嬰幼兒、肌膚脆弱的老人的擦拭片中，希望含刺激性之成分的含量極少，而且含浸有純化水濃度高的水系組成物。另一方面，含浸有純化水濃度高的水系組成物之擦拭片，隨著保存期間的長期化，有產生細菌、霉菌，保存穩定性降低之虞。In order to reduce irritation to the skin, it is desirable that the water-based composition contains a small amount of an antibacterial agent or the like in purified water. In particular, in the wipes used for infants and the elderly with fragile skin, it is desirable that the content of irritating components is extremely small, and the water-based composition with a high concentration of purified water is impregnated. On the other hand, with the wiping sheet impregnated with the water-based composition having a high concentration of purified water, as the storage period is prolonged, bacteria and molds may be generated, and storage stability may be lowered.

下述專利文獻1至專利文獻3中揭示了包含抗菌劑等的水溶液組成物。 下述專利文獻1中記載了作為化妝品等的抗菌･防腐劑在以往被廣泛使用的尼泊金酯(paraben，對羥基苯甲酸酯(parahydroxybenzoic acid ester))中，需要添加界面活性劑等的助溶劑，但是若添加了助溶劑，則尼泊金酯的抗菌･防腐力顯著降低。因此，該專利文獻1中揭示了一種皮膚外用劑，其不含有尼泊金酯，而包含0.2質量%以上的作為(A)成分之2,2-雙(羥基甲基)丙酸正己酯、與前述(A)成分的2倍以上的作為(B)成分之碳數6-8的烷基甘油醚及/或碳數8至12的脂肪酸甘油酯。作為前述脂肪酸甘油酯可列舉癸酸甘油酯。 The following Patent Documents 1 to 3 disclose aqueous compositions containing antibacterial agents and the like. The following Patent Document 1 describes that paraben (parahydroxybenzoic acid ester), which has been widely used in the past as an antibacterial and antiseptic for cosmetics, etc., requires the addition of a surfactant or the like. A co-solvent, but when a co-solvent is added, the antibacterial and anti-corrosion properties of parabens are significantly reduced. Therefore, this patent document 1 discloses an external preparation for skin which does not contain paraben, but contains 0.2 mass % or more of n-hexyl 2,2-bis(hydroxymethyl)propionate as component (A), Alkyl glycerol ether having 6 to 8 carbon atoms and/or glycerol ester of fatty acid having 8 to 12 carbon atoms as the component (B) which is twice or more the amount of the component (A). Capric glyceride is mentioned as said fatty acid glyceride.

下述專利文獻2中揭示了一種發泡抗菌性皮膚洗劑，作為個人護理組成物不包含在環境持續性及健康上有疑慮的三氯沙(Triclosan)，而包含陽離子性活性成分、陽離子相容性界面活性劑、泡沫促進劑、泡沫構造強化劑、及減低對於哺乳類皮膚組織的刺激的皮膚調理劑。作為前述泡沫促進劑，可列舉癸酸甘油酯。下述專利文獻3揭示了一種含有甘油脂肪酸酯等與四級銨鹽之濕毛巾或濕紙巾用的保存劑。The following Patent Document 2 discloses a foaming antibacterial skin lotion that does not contain Triclosan, which is a concern for environmental sustainability and health, as a personal care composition, but contains a cationic active ingredient, a cationic phase, and a cationic active ingredient. Capacitive surfactants, foam boosters, foam texture enhancers, and skin conditioners that reduce irritation to mammalian skin tissue. As said foam accelerator, capric glyceride is mentioned. The following Patent Document 3 discloses a preservative for wet towels or wet tissues containing a glycerin fatty acid ester and the like and a quaternary ammonium salt.

下述的專利文獻4至專利文獻6中揭示了含浸有水溶液組成物的擦拭片等。 下述專利文獻4中揭示了一種將洗淨劑含浸於不織布片之嬰幼兒臀部擦拭用擦拭片。該洗淨劑中的純化水濃度為99.80-99.90重量%的範圍，在該洗淨劑中含有氯化烷基二甲基苄基銨(benzalkonium chloride)與丁基胺甲酸碘代丙炔酯(iodopropynyl butylcarbamate)、及丙二醇或1,3-丁二醇作為殺菌防腐劑。又，記載了這樣的擦拭片可以抑制對於肌膚的刺激性。 The following Patent Documents 4 to 6 disclose wiping sheets and the like impregnated with the aqueous composition. The following Patent Document 4 discloses a wiping sheet for wiping off the buttocks of infants and young children in which a non-woven sheet is impregnated with a detergent. The concentration of purified water in the detergent is in the range of 99.80-99.90% by weight, and the detergent contains benzalkonium chloride and iodopropynyl butylcarbamate ( iodopropynyl butylcarbamate), and propylene glycol or 1,3-butanediol as fungicidal preservatives. Moreover, it is described that such a wiping sheet can suppress irritation|stimulation to skin.

下述專利文獻5中揭示了一種纖維片含浸用之水溶性組成物及含浸有該水溶性組成物之纖維片，其中該水溶性組成物包含聚胺基丙基雙胍與四級銨鹽的混合物、苯甲酸鈉、檸檬酸、乙二胺四乙酸二鈉、及非離子性界面活性劑，且其pH為3.5-4.5。 下述專利文獻6中揭示了一種濕潤片(wet sheet)，其係將液劑含浸於基材片而成，該液劑含有乳酸、檸檬酸或是此等酸的鹽、四級銨鹽型界面活性劑、及水，同時不含有乙醇，而且在25℃中的pH為3.0以上小於6.0。 [先前技術文獻] [專利文獻] The following Patent Document 5 discloses a water-soluble composition for impregnating fiber sheets and a fiber sheet impregnated with the water-soluble composition, wherein the water-soluble composition comprises a mixture of polyaminopropyl biguanide and a quaternary ammonium salt , sodium benzoate, citric acid, disodium edetate, and nonionic surfactant, and its pH is 3.5-4.5. The following Patent Document 6 discloses a wet sheet, which is formed by impregnating a base sheet with a liquid preparation containing lactic acid, citric acid or salts of these acids, quaternary ammonium salt type The surfactant and water do not contain ethanol, and the pH at 25°C is 3.0 or more and less than 6.0. [Prior Art Literature] [Patent Literature]

[專利文獻1]日本特許第4927986號公報 [專利文獻2]日本特許第6431180號公報 [專利文獻3]日本特開2021-003399號公報 [專利文獻4]日本特許第5876981號公報 [專利文獻5]日本特許第5845098號公報 [專利文獻6]日本特開2020-199090號公報 [Patent Document 1] Japanese Patent No. 4927986 [Patent Document 2] Japanese Patent No. 6431180 [Patent Document 3] Japanese Patent Laid-Open No. 2021-003399 [Patent Document 4] Japanese Patent No. 5876981 [Patent Document 5] Japanese Patent No. 5845098 [Patent Document 6] Japanese Patent Laid-Open No. 2020-199090

[發明欲解決之課題][The problem to be solved by the invention]

上述專利文獻1所揭示的前述皮膚外用劑，由於係以在面霜、化妝水、乳液等的添加劑之成分濃度高的溶液中，發揮抗菌･防腐效果為目的而摻合的，所以需要含有比較多量的皮膚外用劑中的抗菌･防腐劑。在上述專利文獻2所揭示的發泡抗菌性皮膚洗劑中，癸酸甘油酯係與聚乙二醇(PEG)8000等的泡沫構造強化劑一起摻合作為泡沫促進劑，用以在洗淨間提供充分的泡沫體積、高密度且穩定的泡沫構造。又，該皮膚洗劑在配方例中，係大量摻合有純水以外的添加劑成分至約15-20重量%。The aforementioned external preparations for skin disclosed in the above-mentioned Patent Document 1 are blended for the purpose of exerting antibacterial and antiseptic effects in solutions with high component concentrations of additives such as creams, lotions, and lotions, and therefore need to contain a relatively large amount. Antibacterial and antiseptic in skin external preparations. In the foaming antibacterial skin lotion disclosed in the above-mentioned Patent Document 2, glyceryl caprate is blended with a foam structure enhancer such as polyethylene glycol (PEG) 8000 as a foam booster, and is used for washing Provides sufficient foam volume, high density and stable foam construction. In addition, in the formulation example of this skin lotion, a large amount of additive components other than pure water is blended to about 15 to 20% by weight.

上述專利文獻3的實施例中，暗示了在保存劑的成分僅為癸酸甘油酯的情形下抗菌性不充分，因此在所揭示的保存劑中作為抗菌劑發揮作用的，估計是氯化烷基二甲基苄基銨等的四級銨鹽。可是，若抗菌劑僅為氯化烷基二甲基苄基銨的話，在pH為弱酸性範圍中抗菌性降低，又，在抗菌劑實質上為1種成分時，由於存在對該抗菌劑有抗性的菌種等，而有可能無法發揮充分的抗菌效果之虞。在上述專利文獻4所揭示的擦拭片中，雖然在含浸的洗淨劑中含有丁基胺甲酸碘代丙炔酯作為殺菌防腐劑，但是希望有不含該成分的擦拭片。又，在該擦拭片中，亦進一步希望防霉性的提升。In the examples of the above-mentioned Patent Document 3, it is suggested that the antibacterial property is insufficient when the component of the preservative is only glyceryl caprate, so the disclosed preservative acts as an antibacterial agent, and it is estimated that chlorinated alkanes The quaternary ammonium salt of dimethyl benzyl ammonium and the like. However, when the antibacterial agent is only alkyldimethylbenzylammonium chloride, the antibacterial property is lowered in the weakly acidic pH range, and when the antibacterial agent is substantially one component, there is a resistant strains, etc., and there is a possibility that a sufficient antibacterial effect may not be exhibited. In the wiping sheet disclosed in the above-mentioned Patent Document 4, although the detergent impregnated contains iodopropynyl butylcarbamate as a bactericidal antiseptic, a wiping sheet which does not contain this component is desired. Moreover, also in this wiping sheet, the improvement of the antifungal property is further desired.

在上述專利文獻5中揭示的纖維片含浸用之水溶性組成物中，添加有苯甲酸鈉作為殺菌防腐劑。苯甲酸鈉係在弱酸性範圍內有效地發揮抗菌性，因此為了調節水溶性組成物的pH，而添加有多種的pH調節劑。再者，由於為了減少對皮膚的刺激，而添加有非離子性界面活性劑，因此添加劑成分的種類變多了。在上述專利文獻6中揭示的含浸於濕潤片的液劑中，記載了相對於四級銨鹽型界面活性劑，摻合3-10倍重量的乳酸、檸檬酸等的摻合例。因此，液劑中的純化水的濃度相對地變低，該文獻中記載了純化水濃度較佳為97.0-99.7質量%。又，雖然記載了在該液劑中摻合上述乳酸、四級銨鹽型界面活性劑等作為除菌劑並針對抗菌性進行了評價，但是並未記載針對防霉性的評價。In the water-soluble composition for impregnation of fiber sheets disclosed in the above-mentioned Patent Document 5, sodium benzoate is added as a bactericidal preservative. Since sodium benzoate effectively exhibits antibacterial properties in a weakly acidic range, various pH adjusters are added in order to adjust the pH of the water-soluble composition. Furthermore, in order to reduce irritation|stimulation to skin, since a nonionic surfactant is added, there are many kinds of additive components. In the liquid preparation to be impregnated in the wet sheet disclosed in the above-mentioned Patent Document 6, a blending example in which lactic acid, citric acid, etc. are blended by 3 to 10 times the weight of the quaternary ammonium salt type surfactant is described. Therefore, the concentration of purified water in the liquid preparation is relatively low, and this document describes that the concentration of purified water is preferably 97.0-99.7% by mass. In addition, although it is described that the above-mentioned lactic acid, a quaternary ammonium salt type surfactant, etc. were blended into the liquid preparation as a microbicidal agent and evaluated for the antibacterial property, the evaluation for the antifungal property is not described.

若為了提升含浸於擦拭片之水系組成物的抗菌性與防霉性雙方而摻合多種的保存性提升劑，則一般會有要將純化水濃度維持在高濃度變得困難的問題點。又，為了減少擦拭片的皮膚刺激性，理想的是將純化水濃度維持在高濃度並將pH調節至弱酸性範圍，但是在該情形下，需要添加pH調節劑，又在pH為弱酸性範圍中，根據抗菌劑的種類而存在有抗菌性降低的問題點。 本發明係鑑於這樣的情況而完成者，目的係提供一種擦拭片、及該擦拭片含浸用之水系組成物，該擦拭片係藉由在含浸於基材片之水系組成物中選擇並摻合特定的保存穩定劑來提高抗菌性與防霉性，同時將純化水維持在高濃度，而且使pH可維持在弱酸性，亦適合使用於肌膚細緻的嬰幼兒、肌膚脆弱的老人。 [用以解決課題之手段] In order to improve both the antibacterial properties and the antifungal properties of the water-based composition impregnated in the wiper sheet, if a plurality of storability enhancers are blended, it is generally difficult to maintain the purified water concentration at a high concentration. In addition, in order to reduce the skin irritation of the wiping sheet, it is desirable to maintain the purified water concentration at a high concentration and adjust the pH to the weakly acidic range, but in this case, it is necessary to add a pH adjuster, and the pH is in the weakly acidic range Among them, there is a problem that the antibacterial property decreases depending on the type of the antibacterial agent. The present invention has been made in view of such circumstances, and an object of the present invention is to provide a wiping sheet and an aqueous composition for impregnation of the wiping sheet, which are selected and blended from the aqueous composition impregnated into the substrate sheet, and an aqueous composition for impregnation thereof. The specific preservation stabilizer improves the antibacterial and antifungal properties, and at the same time maintains the purified water at a high concentration and maintains the pH at a weak acid level. It is also suitable for infants with delicate skin and the elderly with fragile skin. [means to solve the problem]

本案發明人等有鑑於上述以往技術，為了提高擦拭片含浸用之水系組成物的保存性，發現併用有受到pH影響的可能性的氯化烷基二甲基苄基銨、與受到pH影響的可能性少的聚胺基丙基雙胍鹽酸鹽作為抗菌劑，同時含有癸酸甘油酯作為防霉劑，並且基於該癸酸甘油酯的摻合而含有助溶劑，再者，為了抑制對皮膚的刺激性，而將該水系組成物中的純化水濃度維持在高濃度，同時分別以規定量含有氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽，使水系組成物的pH可保持在弱酸性範圍內，藉此能得到保存穩定性優異，進而能減少對皮膚的刺激的擦拭片，而完成了本發明。 亦即，本發明係關於以下記載的「1.擦拭片」、及「2.擦拭片含浸用之水系組成物」的發明。 In view of the above-mentioned prior art, the inventors of the present application found that, in order to improve the storage stability of the water-based composition for impregnation of the wiping sheet, the combined use of alkyldimethylbenzylammonium chloride, which may be affected by pH, and a pH-affected water-based composition Polyaminopropyl biguanide hydrochloride, which is less likely to be used as an antibacterial agent, contains capric glyceride as an antifungal agent, and also contains a cosolvent based on the blending of the capric glyceride. The irritant, and the purified water concentration in the water system composition is maintained at a high concentration, and at the same time, alkyl dimethyl benzyl ammonium chloride and polyaminopropyl biguanide hydrochloride are contained in predetermined amounts, respectively, so that the water system composition The pH of the substance can be maintained in the weakly acidic range, thereby obtaining a wipe sheet having excellent storage stability and further reducing irritation to the skin, thereby completing the present invention. That is, this invention is about the invention concerning "1. Wiping sheet" and "2. Aqueous composition for wiping sheet impregnation" described below.

1.關於「擦拭片」的發明 一種擦拭片，其係在由織布或不織布構成的基材片中含浸有包含保存性提升劑與助溶劑的水系組成物而成之擦拭片， 其特徵係前述水系組成物在純化水中包含：抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、及防霉劑成分之癸酸甘油酯作為保存性提升劑，以及使癸酸甘油酯溶解的溶劑作為助溶劑， 在前述水系組成物中，氯化烷基二甲基苄基銨的含量(b1)為0.030質量%以上0.050質量%以下，聚胺基丙基雙胍鹽酸鹽的含量(b2)為0.025質量%以上0.070質量%以下，癸酸甘油酯的含量(c1)為0.003質量%以上0.050質量%以下， 並且，在前述水系組成物中，純化水的濃度為99.85質量%以上99.92質量%以下。 1. About the invention of "wipe sheet" A wiping sheet, which is a wiping sheet obtained by impregnating a substrate sheet consisting of a woven or non-woven fabric with an aqueous composition containing a preservation enhancer and a cosolvent, It is characterized in that the aforementioned water-based composition contains in purified water: alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride as antibacterial agent components, and capric glyceride as antifungal agent component as preservation properties. A lifter, and a solvent that dissolves glyceryl caprate as a cosolvent, In the aforementioned water-based composition, the content (b1) of alkyldimethylbenzylammonium chloride is 0.030 mass % or more and 0.050 mass % or less, and the content (b2) of polyaminopropyl biguanide hydrochloride is 0.025 mass % 0.070 mass % or more, the content (c1) of capric glyceride is 0.003 mass % or more and 0.050 mass % or less, Moreover, in the said water-system composition, the density|concentration of purified water is 99.85 mass % or more and 99.92 mass % or less.

2.關於「擦拭片含浸用之水系組成物」的發明 一種擦拭片含浸用之水系組成物，其係在純化水中包含：抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、及防霉劑成分之癸酸甘油酯作為保存性提升劑， 以及使癸酸甘油酯溶解的溶劑作為助溶劑之擦拭片含浸用之水系組成物， 其特徵係在前述水系組成物中，氯化烷基二甲基苄基銨的含量(b1)為0.030質量%以上0.050質量%以下，聚胺基丙基雙胍鹽酸鹽的含量(b2)為0.025質量%以上0.070質量%以下，及癸酸甘油酯的含量(c1)為0.003質量%以上0.050質量%以下， 並且在前述水系組成物中，純化水的濃度為99.85質量%以上99.92質量%以下。 [發明之效果] 2. Invention of "Aqueous Composition for Impregnation of Wipe Sheets" A water-based composition for impregnating a wiper sheet, comprising in purified water: alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride as antibacterial agents, and capric acid as antifungal agent Glycerides act as preservation enhancers, and a water-based composition for impregnating a wiper sheet with a solvent that dissolves glyceryl caprate as a cosolvent, It is characterized in that in the aforementioned water-based composition, the content (b1) of alkyldimethylbenzylammonium chloride is 0.030 mass % or more and 0.050 mass % or less, and the content (b2) of polyaminopropyl biguanide hydrochloride is 0.025 mass % or more and 0.070 mass % or less, and the content (c1) of capric glyceride is 0.003 mass % or more and 0.050 mass % or less, And in the said water system composition, the density|concentration of purified water is 99.85 mass % or more and 99.92 mass % or less. [Effect of invention]

本發明的擦拭片係在由織布或不織布構成的基材片中含浸有水系組成物，該水系組成物中分別以特定量含有抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、及防霉劑成分之癸酸甘油酯作為保存性提升劑。因此，本發明的擦拭片藉由提高抗菌性與防霉性雙方，而提高了保存穩定性。In the wiping sheet of the present invention, a substrate sheet composed of a woven or non-woven fabric is impregnated with a water-based composition, and the water-based composition contains an antibacterial agent component, alkyldimethylbenzylammonium chloride and a polymer, respectively, in specific amounts. Aminopropyl biguanide hydrochloride and capric glyceride as an antifungal ingredient are used as preservation enhancers. Therefore, the wiping sheet of this invention improves storage stability by improving both antibacterial properties and antifungal properties.

又，在本發明的擦拭片中，儘可能地減少含浸的水系組成物中的保存性提升劑與助溶劑的含量並提高純化水濃度，再者，分別以規定量含有氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽，使pH保持在弱酸性範圍內，藉此減少因擦拭片造成之對皮膚的刺激。 本發明的擦拭片含浸用之水系組成物被含浸於擦拭片，而如上述針對擦拭片所述，提高擦拭片的保存穩定性，而且發揮了減少因擦拭片造成之對皮膚的刺激的效果。 Moreover, in the wiping sheet of the present invention, the content of the preservative enhancer and the cosolvent in the water-based composition to be impregnated is reduced as much as possible, and the concentration of purified water is increased, and furthermore, alkyl dimethyl chloride is contained in a predetermined amount, respectively. Benzyl benzyl ammonium and polyaminopropyl biguanide hydrochloride keep the pH in the weak acid range, thereby reducing skin irritation caused by the wiper sheet. The water-based composition for impregnating the wiping sheet of the present invention is impregnated into the wiping sheet, and as described above for the wiping sheet, the storage stability of the wiping sheet is improved, and the effect of reducing skin irritation due to the wiping sheet is exhibited.

[用以實施發明的形態][Form for carrying out the invention]

以下，將本發明分為「1.擦拭片」與「2.擦拭片用之水系組成物」來詳細說明。 1.關於「擦拭片」的發明 以下將本發明的擦拭片分為(1)基材片、(2)水系組成物、(3)擦拭片來進行說明。 Hereinafter, the present invention will be described in detail by dividing it into "1. wiping sheet" and "2. water-based composition for wiping sheet". 1. About the invention of "wipe sheet" Hereinafter, the wiping sheet of the present invention is divided into (1) a base sheet, (2) a water-based composition, and (3) a wiping sheet, and will be described.

(1)基材片 本發明的擦拭片中所使用的基材片，可使用織布或不織布中的任一者，但較佳為使用不織布。不織布係將纖維不進行編織而纏繞在一起的片材，具體而言，使纖維藉由熱、物理性或化學性作用進行黏接或纏繞而形成片狀。作為織布或不織布的材料，可列舉聚丙烯纖維、聚對苯二甲酸乙二酯纖維、聚醯胺纖維、嫘縈纖維、丙烯酸纖維、聚胺基甲酸酯纖維、紙漿纖維(亦包含紙)、及包含此等2種以上的複合纖維，但是為了賦予基材片較佳的功能，較佳為使用複合纖維。 (1) Substrate sheet As the base sheet used for the wiping sheet of the present invention, either a woven fabric or a non-woven fabric can be used, but it is preferable to use a non-woven fabric. Non-woven fabrics are sheets in which fibers are entangled without weaving. Specifically, fibers are bonded or entangled by thermal, physical or chemical action to form a sheet. Examples of woven or non-woven materials include polypropylene fibers, polyethylene terephthalate fibers, polyamide fibers, rayon fibers, acrylic fibers, polyurethane fibers, pulp fibers (including paper ), and these two or more kinds of conjugated fibers are included, but in order to impart a better function to the base sheet, it is preferable to use the conjugated fibers.

在使用複合纖維的情形下，較佳為包含吸濕性高，而且親膚觸感良好的嫘縈纖維。作為較佳的複合纖維，可列舉包含聚對苯二甲酸乙二酯纖維與嫘縈纖維的複合纖維，而在該情形下更佳為在複合纖維中包含40-60質量%的嫘縈纖維。又，作為其他較佳的複合纖維，可列舉包含紙漿纖維與嫘縈纖維的複合纖維，而在該情形下更佳為在複合纖維中包含10-30質量%的嫘縈纖維。 基材片的基重較佳為20-80g/m 2，更佳為30-60g/m 2。此外，理想的是基材片在使水系組成物含浸之前或含浸之後以紫外線照射等進行殺菌處理。 When a conjugated fiber is used, it is preferable to contain a rayon fiber having high hygroscopicity and good skin-friendly touch. Preferable conjugate fibers include conjugate fibers containing polyethylene terephthalate fibers and rayon fibers, and in this case, it is more preferred to contain 40 to 60% by mass of rayon fibers in the conjugate fibers. Moreover, as another preferable conjugated fiber, the conjugated fiber containing pulp fiber and rayon fiber is mentioned, In this case, it is more preferable to contain 10-30 mass % of rayon fiber in the conjugated fiber. The basis weight of the substrate sheet is preferably 20-80 g/m 2 , more preferably 30-60 g/m 2 . In addition, it is desirable that the substrate sheet is sterilized by ultraviolet irradiation or the like before or after impregnation with the water-based composition.

(2)水系組成物 (2-1)純化水 水系組成物中使用的純化水係例如較佳為使用自來水等的普通水，視需要在前處理後，藉由組合由離子交換、蒸餾、過濾等所選擇之1種或2種以上的手段來進行純化，更佳為進一步藉由紫外線殺菌裝置等來進行殺菌處理。作為水的殺菌處理，可列舉紫外線殺菌、熱殺菌、臭氧水殺菌、氯系殺菌等，但是較佳為不需要大型的設備、大量熱量，不對水質造成影響的紫外線殺菌。藉由上述手段所得的純化水，在純化後、或經純化與殺菌處理後的導電度，較佳係在25℃時為1μS/cm以下。 (2) Water system composition (2-1) Purified water The purified water used in the water system composition is preferably ordinary water such as tap water, and it is obtained by combining one or more means selected from ion exchange, distillation, filtration, etc. after pretreatment as necessary. Purification is performed, and it is more preferable to perform a sterilization treatment by an ultraviolet sterilizer or the like. Examples of the water sterilization treatment include ultraviolet sterilization, thermal sterilization, ozone water sterilization, and chlorine-based sterilization. However, ultraviolet sterilization that does not require large-scale equipment and a large amount of heat and does not affect water quality is preferred. The conductivity of the purified water obtained by the above-mentioned means after purification or after purification and sterilization treatment is preferably 1 μS/cm or less at 25°C.

(2-2)保存性提升劑 為了在將擦拭片使用於擦嬰幼兒的臀部、或是病人、老人、嬰幼兒的身體擦拭用等的情形下減少對皮膚的刺激，較佳為含浸於擦拭片的水系組成物中的純化水的濃度高。另一方面，由於純化水濃度越高的水系組成物，越容易在保存中產生細菌、霉菌，因此會發生保存上的問題。因此，為了儘可能減少水系組成物中的保存性提升劑濃度以減少對皮膚的刺激性，同時賦予水系組成物抗菌性與防霉性而能長期間的保存，保存性提升劑的選擇與其含量的決定是非常重要的。 (2-2) Preservation enhancer Purified water impregnated in the water-based composition of the wiping sheet is preferable in order to reduce skin irritation when the wiping sheet is used for wiping the buttocks of infants, or the body of patients, the elderly, and infants. high concentration. On the other hand, since the water-system composition with the higher purified water concentration is more likely to generate bacteria and molds during storage, a problem in storage occurs. Therefore, in order to reduce the concentration of the preservative enhancer in the water-based composition as much as possible to reduce irritation to the skin, and at the same time to impart antibacterial and antifungal properties to the water-based composition to enable long-term preservation, the selection and content of the preservative enhancer decision is very important.

作為保存性提升劑，已知有各種的抗菌劑等，但是本發明中，考慮到有避免使用迄今廣泛使用的前述尼泊金酯的傾向，作為保存性提升劑，使用了均用於化妝品的抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、及防霉劑成分之癸酸甘油酯。 在本發明中，上述所謂的「抗菌劑成分」係指主要發揮抗菌性的成分，上述所謂的「防霉劑成分」係指主要發揮防霉性的成分。 Various antibacterial agents and the like are known as preservative enhancers, but in the present invention, considering the tendency to avoid the use of the aforementioned parabens, which have been widely used so far, as preservative enhancers, both of which are used in cosmetics are used. Alkyl dimethyl benzyl ammonium chloride and polyaminopropyl biguanide hydrochloride as the antibacterial ingredients, and capric glyceride as the antifungal ingredient. In the present invention, the above-mentioned "antibacterial agent component" refers to a component that mainly exhibits antibacterial properties, and the above-mentioned "antifungal agent component" refers to a component that mainly exhibits antifungal properties.

作為抗菌劑成分，氯化烷基二甲基苄基銨被列入可摻合於化妝品的防腐劑清單(正面表列清單)中，但是理想為減少其含量。若抗菌劑成分為僅包含氯化烷基二甲基苄基銨的成分，則有在pH為弱酸性範圍內抗菌性降低之虞，又由於對於該抗菌劑有抗性的菌種的存在等，而有無法充分發揮抗菌效果之虞。因此，作為抗菌劑成分較佳為使用至少2成分，所以本發明中，併用氯化烷基二甲基苄基銨、與因pH變化而抗菌性的降低少的聚胺基丙基雙胍鹽酸鹽作為抗菌劑成分。除了藉由該併用可以提高抗菌性外，藉由調整氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽的含有比例，亦可將水系組成物的pH調節為皮膚刺激性少的弱酸性。As an antimicrobial ingredient, alkyldimethylbenzylammonium chloride is included in the list of preservatives that can be blended into cosmetics (positive list), but it is desirable to reduce its content. If the antibacterial agent component is a component containing only alkyldimethylbenzylammonium chloride, the antibacterial properties may be lowered in the weakly acidic pH range, and the presence of bacterial species resistant to the antibacterial agent may occur. , and there is a possibility that the antibacterial effect cannot be fully exerted. Therefore, it is preferable to use at least two components as an antibacterial agent component. Therefore, in the present invention, alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride, which has a small decrease in antibacterial properties due to pH changes, are used in combination. Salt as an antibacterial ingredient. In addition to improving the antibacterial properties by this combined use, the pH of the water-based composition can also be adjusted to prevent skin irritation by adjusting the content ratio of alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride. Weak acidity with little sex.

由於在僅選擇抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽這2種作為保存性提升劑的情形下，無法期待充分的防霉性，因此藉由進一步併用防霉劑成分之癸酸甘油酯，除了提高防菌性外，亦可提高防霉性。此外，在水系組成物中含有癸酸甘油酯的情形下，由於該成分對於水溶液的溶解性低，因此需要含有使癸酸甘油酯溶解的溶劑作為助溶劑。When only two kinds of antibacterial agent components, alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride, are selected as the preservative enhancers, sufficient antifungal properties cannot be expected. In addition to improving the antibacterial property, the antifungal property can also be improved by using the capric glyceride as an antifungal agent component in combination. In addition, when the aqueous composition contains capric glyceride, since the solubility of this component in an aqueous solution is low, it is necessary to contain a solvent for dissolving capric glyceride as a cosolvent.

藉由併用氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽作為抗菌劑成分，亦可減少氯化烷基二甲基苄基銨的含量。如上所述，本發明的特徵係藉由使水系組成物中含有氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽，以提高抗菌性，進一步含有癸酸甘油酯以提高防霉性，從而在提高保存穩定性的同時將水系組成物的pH調節為弱酸性，而可以得到對人體皮膚的刺激性低的水系組成物。By using alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride together as antibacterial ingredients, the content of alkyldimethylbenzylammonium chloride can also be reduced. As described above, the present invention is characterized in that the aqueous composition contains alkyl dimethyl benzyl ammonium chloride and polyaminopropyl biguanide hydrochloride to improve antibacterial properties, and further contains capric glyceride to improve antibacterial properties. By improving the antifungal properties, the pH of the water-based composition is adjusted to be weakly acidic while the storage stability is improved, and the water-based composition with low irritation to human skin can be obtained.

以下針對保存性提升劑、與助溶劑的成分進行說明。 (2-3)保存性提升劑中的各成分 (i)氯化烷基二甲基苄基銨 在化妝品領域中被廣泛作為抗菌劑成分使用的氯化烷基二甲基苄基銨，化學名稱為烷基二甲基苄基氯化銨(alkyl dimethyl benzyl ammonium chloride)，以下述的化學式(1)表示。 [RC 6H 5CH 2N +(CH 3) 2]Cl −･･･････････(1) 上述化學式(1)所示之氯化烷基二甲基苄基銨包含烷基(R)的一部分或全部為碳數8至18(C 8H 17-C 18H 37)的烷基之混合物。 The components of the preservative enhancer and the cosolvent will be described below. (2-3) Components in the Preservative Enhancer (i) Alkyldimethylbenzylammonium chloride, which is widely used as an antibacterial ingredient in the cosmetic field, is chemically The name is alkyl dimethyl benzyl ammonium chloride, and it is represented by the following chemical formula (1). [RC 6 H 5 CH 2 N + (CH 3 ) 2 ]Cl − ････････････(1) The alkyldimethylbenzylammonium chloride represented by the above chemical formula (1) contains A part or the whole of the alkyl group (R) is a mixture of alkyl groups having 8 to 18 carbon atoms (C 8 H 17 -C 18 H 37 ).

氯化烷基二甲基苄基銨其稀釋水溶液的pH為弱鹼性，在該弱鹼性中雖發揮優異的殺菌性，但是另一方面，若成為pH為中性至弱酸性的水溶液，則殺菌性降低。例如，列舉市售的氯化烷基二甲基苄基銨的水溶液為一例，若使用石炭酸係數(以石炭酸為基準，表示殺菌力為石炭酸的多少倍的數值)來表示pH與殺菌性的關係，則已知於常溫附近在pH7的殺菌力分別降低至在pH9、11的殺菌力的約0.86、0.54倍，在pH5的殺菌力分別降低至在pH9、11的殺菌力的約0.78、0.49倍。The pH of the diluted aqueous solution of alkyldimethylbenzylammonium chloride is weakly alkaline, and although excellent bactericidal properties are exhibited in this weakly alkaline, on the other hand, if it is an aqueous solution whose pH is neutral to weakly acidic, The bactericidal property is reduced. For example, taking a commercially available aqueous solution of alkyldimethylbenzylammonium chloride as an example, the relationship between pH and bactericidal properties is expressed using the carbolic acid coefficient (a numerical value indicating how many times the bactericidal power is that of carbolic acid based on carbolic acid). , it is known that the bactericidal power at pH 7 is reduced to about 0.86 and 0.54 times of the bactericidal power at pH 9 and 11, respectively, and the bactericidal power at pH 5 is reduced to about 0.78 and 0.49 times of the bactericidal power at pH 9 and 11, respectively. .

(ii)聚胺基丙基雙胍鹽酸鹽 聚胺基丙基雙胍係下述的化學式(2)所示之在分子中具有多數陽電荷的陽離子性高分子。 [-NH-C(=NH)-NH-C(=NH)-NH-(CH 2) 3-] n･････(2) 已知聚胺基丙基雙胍存在有鹽酸鹽等的無機酸鹽、及富馬酸鹽等的有機酸鹽等。在使用於抗菌劑的情形下，可使用聚胺基丙基雙胍、及聚胺基丙基雙胍無機酸鹽等，但本發明中，較佳為聚胺基丙基雙胍鹽酸鹽。 (ii) Polyaminopropyl biguanide hydrochloride Polyaminopropyl biguanide is a cationic polymer having a large number of positive charges in the molecule represented by the following chemical formula (2). [-NH-C(=NH)-NH-C(=NH)-NH-(CH 2 ) 3 -] n ･････(2) Polyaminopropyl biguanide is known to exist as hydrochloride, etc. of inorganic acid salts, and organic acid salts such as fumarate. When used for an antibacterial agent, polyaminopropyl biguanide, polyaminopropyl biguanide inorganic acid salt, etc. can be used, but in the present invention, polyaminopropyl biguanide hydrochloride is preferable.

聚胺基丙基雙胍鹽酸鹽對於水的溶解度高，即使在寬廣的溫度範圍、pH範圍下抗菌活性也穩定。又，已知聚胺基丙基雙胍鹽酸鹽由於對大腸桿菌、金黃色葡萄球菌、綠膿桿菌等具有抗菌性，因此對細菌具有寬廣的抗菌光譜，但是另一方面，對於念珠菌屬(candidas)、黑麴菌屬(black aspergillus)等的真菌，防霉效果比較低。 在上述化學式(2)中，聚胺基丙基雙胍的聚合度n較佳為2以上50以下，更佳為10以上20以下。又，聚胺基丙基雙胍的重量平均分子量較佳為300以上8000以下，更佳為2000以上3000以下。此外，重量平均分子量(Mw)可藉由眾所周知的測定法而求得。 Polyaminopropyl biguanide hydrochloride has high solubility in water, and its antibacterial activity is stable even in a wide temperature range and pH range. In addition, it is known that polyaminopropyl biguanide hydrochloride has antibacterial properties against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, etc., and therefore has a broad antibacterial spectrum against bacteria, but on the other hand, it is known that Candida ( candidas), black aspergillus (black aspergillus) and other fungi, the anti-mildew effect is relatively low. In the above chemical formula (2), the polymerization degree n of the polyaminopropyl biguanide is preferably 2 or more and 50 or less, more preferably 10 or more and 20 or less. Moreover, 300 or more and 8000 or less are preferable, and, as for the weight average molecular weight of a polyaminopropyl biguanide, 2000 or more and 3000 or less are more preferable. In addition, the weight average molecular weight (Mw) can be calculated|required by a well-known measuring method.

(iii)癸酸甘油酯 癸酸甘油酯係碳數10的飽和脂肪酸之癸酸與甘油的單酯，存在有下述的化學式(3)與式(4)所示之2種異構物。 CH 2OH-CHOH-CH 2-O-CO-(CH 2) 8CH 3････(3) CH 2OH-CH-O-(CO-(CH 2) 8CH 3)-CH 2OH ･･(4) 分別已知有碳數8、10、12的脂肪酸與甘油的單酯。此等之中，若考慮到因與其他抗菌劑成分等的併用所引起的抗菌性與防霉性的相乘效果、對使用了助溶劑的水溶液的溶解性、在低濃度下防霉性的效果、取得的容易性等，則作為防霉劑成分，較佳為碳數10的癸酸與甘油的單酯之癸酸甘油酯。 (iii) Glycerin capric acid Glyceryl capric acid is a monoester of capric acid and glycerol of a saturated fatty acid having 10 carbon atoms, and there are two kinds of isomers represented by the following chemical formulas (3) and (4). CH 2 OH-CHOH-CH 2 -O-CO-(CH 2 ) 8 CH 3 ････(3) CH 2 OH-CH-O-(CO-(CH 2 ) 8 CH 3 )-CH 2 OH ･･(4) Monoesters of fatty acids having 8, 10, and 12 carbon atoms and glycerol are known, respectively. Among these, considering the synergistic effect of antibacterial properties and antifungal properties due to the combined use with other antibacterial agents, solubility in aqueous solutions using cosolvents, and antifungal properties at low concentrations In terms of effects, easiness of acquisition, and the like, as the antifungal agent component, capric glyceride, which is a monoester of capric acid having 10 carbon atoms and glycerol, is preferred.

癸酸甘油酯一般係用甘油將來自天然的大豆油等的植物油性脂肪酸予以酯化而合成的非離子界面活性劑。癸酸甘油酯由於在常溫為固體，並且為親油性，因此對水溶液的溶解度在25℃中為約126mg/公升。癸酸甘油酯在化妝品的領域中，主要是使用於油性製品、乳化系製品，但也可與助溶劑併用，而摻混至水系製品中。Capric glyceride is generally a nonionic surfactant synthesized by esterifying a vegetable oily fatty acid derived from natural soybean oil or the like with glycerin. Since capric glyceride is solid at room temperature and lipophilic, its solubility in an aqueous solution is about 126 mg/liter at 25°C. In the field of cosmetics, capric glyceride is mainly used in oil-based products and emulsified products, but it can also be used in combination with a co-solvent and mixed into water-based products.

(2-4)保存性提升劑中各成分的含量 為了提高本發明的擦拭片的保存穩定性，減少皮膚刺激性，需要如下述般設定含浸於擦拭片之水系組成物中的保存性提升劑的各成分的摻合範圍。 (2-4) Content of each component in the preservative enhancer In order to improve the storage stability of the wiping sheet of the present invention and reduce skin irritation, it is necessary to set the blending range of each component of the storage stability enhancer impregnated in the water-based composition of the wiping sheet as follows.

水系組成物中的抗菌劑成分之氯化烷基二甲基苄基銨的含量(b1)為0.030質量%以上0.050質量%以下，較佳為0.035質量%以上0.050質量%以下。 水系組成物中的抗菌劑成分之聚胺基丙基雙胍鹽酸鹽的含量(b2)為0.025質量%以上0.070質量%以下，較佳為0.035質量%以上0.070質量%以下。水系組成物中的防霉劑成分之癸酸甘油酯的含量(c1)為0.003質量%以上0.050質量%以下，較佳為0.0035質量%以上0.050質量%以下。 The content (b1) of alkyldimethylbenzylammonium chloride as the antimicrobial component in the water-based composition is 0.030 mass % or more and 0.050 mass % or less, preferably 0.035 mass % or more and 0.050 mass % or less. The content (b2) of the polyaminopropyl biguanide hydrochloride as the antibacterial agent component in the water-based composition is 0.025 mass % or more and 0.070 mass % or less, preferably 0.035 mass % or more and 0.070 mass % or less. Content (c1) of capric glyceride as the antifungal agent component in the water-based composition is 0.003 mass % or more and 0.050 mass % or less, preferably 0.0035 mass % or more and 0.050 mass % or less.

在本發明的水系組成物中，氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、癸酸甘油酯在前述含量中，分別有效地發揮抗菌性、防霉性。In the water-based composition of the present invention, alkyldimethylbenzylammonium chloride, polyaminopropyl biguanide hydrochloride, and capric glyceride in the aforementioned contents effectively exert antibacterial properties and antifungal properties, respectively.

(2-5)保存性提升劑的各成分的含有比例 若進一步考慮到本發明的擦拭片的保存穩定性與減低皮膚刺激性，則較佳為如下述般設定在含浸於該擦拭片之水系組成物中的保存性提升劑之各成分的含有比例。 若考慮到抗菌性，則氯化烷基二甲基苄基銨的含量(b1)與聚胺基丙基雙胍鹽酸鹽的含量(b2)的合計量(b1+b2)較佳為0.06質量%以上0.105質量%以下，若為了減少皮膚刺激性而考慮到水系組成物的pH，則聚胺基丙基雙胍鹽酸鹽的含量(b2)與氯化烷基二甲基苄基銨的含量(b1)的質量比(b2/b1)較佳為0.625以上2.00以下。 (2-5) Content ratio of each component of the preservative enhancer In consideration of the storage stability and skin irritation reduction of the wiping sheet of the present invention, the content ratio of each component of the storage stability enhancer in the water-based composition impregnated in the wiping sheet is preferably set as follows. In consideration of antibacterial properties, the total amount (b1+b2) of the content (b1) of the alkyldimethylbenzylammonium chloride and the content (b2) of the polyaminopropyl biguanide hydrochloride is preferably 0.06 mass % or more and 0.105 mass % or less, when the pH of the water-based composition is considered in order to reduce skin irritation, the content (b2) of polyaminopropyl biguanide hydrochloride and the content of alkyldimethylbenzylammonium chloride The mass ratio (b2/b1) of (b1) is preferably 0.625 or more and 2.00 or less.

又，若考慮到水系組成物的抗菌性與防霉性雙方的提升，則防霉劑成分之癸酸甘油酯的含量(c1)、與抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽的含量(b2)的合計量(b1+b2)的質量比(c1/(b1+b2))，較佳為0.035以上0.833以下。Furthermore, considering the improvement of both the antibacterial properties and the antifungal properties of the water-based composition, the content (c1) of glyceryl caprate as the antifungal agent component and the alkyldimethylbenzylammonium chloride as the antibacterial agent component The mass ratio (c1/(b1+b2)) of the total amount (b1+b2) to the content (b2) of polyaminopropyl biguanide hydrochloride is preferably 0.035 or more and 0.833 or less.

(2-6)助溶劑 如上所述，由於癸酸甘油酯於水溶液的溶解度非常低，因此為了使癸酸甘油酯均勻地溶解於水系組成物中，需要含有使癸酸甘油酯溶解的溶劑。作為溶劑，只要能將癸酸甘油酯均勻地溶解於水系組成物中即可，沒有特別限制，但是若考慮到與癸酸甘油酯的溶解性、水溶性、含量、安全性等，則較佳為在常溫(15-25℃)中為液狀，而且具有OH末端基的聚醚。作為這樣的聚醚，除了將環氧乙烷加成反應所得之聚乙二醇外，還可列舉使環氧乙烷、與環氧丙烷或1,3-環氧丁烷等加成反應而成之聚醚。此等聚醚由於均具有醚鍵與在末端具有OH鍵，因此是優異的溶劑並對熱穩定，而且對許多的化學藥品為比較惰性的。 (2-6) Cosolvent As described above, since the solubility of capric glyceride in an aqueous solution is very low, it is necessary to contain a solvent for dissolving capric glyceride in order to uniformly dissolve capric glyceride in the aqueous composition. The solvent is not particularly limited as long as it can dissolve capric glyceride uniformly in the water-based composition, but it is preferable in consideration of solubility with capric glyceride, water solubility, content, safety, and the like It is a polyether that is liquid at room temperature (15-25°C) and has an OH end group. As such a polyether, in addition to polyethylene glycol obtained by addition reaction of ethylene oxide, ethylene oxide, propylene oxide, 1,3-butylene oxide, etc. can be added by addition reaction. into the polyether. Since these polyethers all have ether bonds and OH bonds at the terminals, they are excellent solvents and thermally stable, and are relatively inert to many chemicals.

前述聚醚之中，若考慮到在常溫中為液狀、與刺激性的減少、癸酸甘油酯的溶解性，則更佳係數量平均分子量為100以上600以下的聚乙二醇，進一步較佳係數量平均分子量為200以上300以下的聚乙二醇。數量平均分子量為100以上600以下的聚乙二醇係蒸氣壓低，若以低濃度溶解於水溶液，則亦能抑制黏性。此外，為了減少對皮膚的刺激，較佳為不含有如甲醇、乙醇的低級醇。 為了維持對於水系組成物的溶解性與防止黏性，及為了將純化水濃度維持於高濃度，水系組成物中的溶劑的含量(d1)與癸酸甘油酯的含量(c1)的質量比(d1/c1)，較佳為0.60以上2.14以下。 Among the above-mentioned polyethers, in consideration of being liquid at room temperature, reducing irritation, and solubility of glyceryl caprate, polyethylene glycol having a number average molecular weight of 100 or more and 600 or less is more preferable. The polyethylene glycol with a number average molecular weight of 200 or more and 300 or less is preferred. Polyethylene glycols having a number average molecular weight of 100 or more and 600 or less have a low vapor pressure, and when dissolved in an aqueous solution at a low concentration, viscosity can be suppressed. Moreover, in order to reduce irritation|stimulation to skin, it is preferable not to contain lower alcohols, such as methanol and ethanol. In order to maintain the solubility in the water-based composition and prevent stickiness, and to maintain the purified water concentration at a high concentration, the mass ratio of the solvent content (d1) to the capric glyceride content (c1) in the water-based composition ( d1/c1), preferably 0.60 or more and 2.14 or less.

(2-7)水系組成物中的純化水濃度與pH值 在前述水系組成物中，純化水的濃度為99.85質量%以上99.92質量%以下。該水系組成物係在純化水中含有保存性提升劑與助溶劑，但是如上所述藉由將每一者的含量均設為少量，可將純化水維持在高濃度，且可謀求減低皮膚刺激性。 又，若考慮到減少對嬰幼兒、老人或肌膚脆弱的病人等的皮膚刺激性、如後所述般皮膚表面的pH為弱酸性等，則在25℃中水系組成物的pH較佳為3.47-3.83。此外，水系組成物的pH值為使用堀場製作所(股)製的HORIBA pH METER F-21所得之測定值。若將在這樣pH範圍的水系組成物含浸於例如由包含聚對苯二甲酸乙二酯纖維與嫘縈纖維的複合纖維等所得之不織布片，則能將所得之擦拭片中的水相部的pH維持在弱酸性之6.1-6.6左右，可減少以擦拭片擦拭身體時的皮膚刺激。 (2-7) Purified water concentration and pH value in water system composition In the said water-system composition, the density|concentration of purified water is 99.85 mass % or more and 99.92 mass % or less. This water-based composition contains a preservative enhancer and a cosolvent in purified water, but by making the content of each of them small as described above, the purified water can be maintained at a high concentration and skin irritation can be reduced. . In addition, in consideration of reducing skin irritation to infants, the elderly, and patients with fragile skin, and the pH of the skin surface being weakly acidic as described later, the pH of the aqueous composition at 25°C is preferably 3.47. -3.83. In addition, the pH value of an aqueous composition is a measured value using HORIBA pH METER F-21 by Horiba Corporation. By impregnating a non-woven fabric sheet obtained from, for example, a conjugate fiber containing polyethylene terephthalate fibers and rayon fibers, or the like with an aqueous composition having such a pH range, the water phase portion of the obtained wiping sheet can be removed. The pH is maintained at about 6.1-6.6 of weak acid, which can reduce the skin irritation when wiping the body with the wiper.

(2-8)其他添加劑 在不損及保存性提升劑的效果之範圍內，水系組成物中亦可含有少量的其他添加劑。作為這種添加劑，可列舉具有保濕作用的玻尿酸、膠原蛋白等。 (2-8) Other additives A small amount of other additives may be contained in the water-based composition within the range that does not impair the effect of the preservative enhancer. Examples of such additives include hyaluronic acid, collagen, and the like, which have a moisturizing effect.

(3)擦拭片 本發明適用的擦拭片係在前述由織布或不織布構成的基材片中含浸有水系組成物而成的片材，不限定於嬰幼兒臀部擦拭用、病人、老人、嬰幼兒等的身體擦拭用，可進一步廣泛地使用於卸妝用棉片、擦手紙、廚房用擦拭紙巾、OA製品用清潔劑等。 (3) Wiping sheet The wiping sheet to which the present invention is applied is a sheet obtained by impregnating the aforementioned base sheet made of woven or non-woven fabric with a water-based composition, and is not limited to wiping the buttocks of infants, and body wiping of patients, the elderly, and infants. It can be further widely used in cotton pads for makeup removal, toilet paper, kitchen wipes, cleaning agents for OA products, and the like.

(3-1)水系組成物對於基材片之含浸 作為使水系組成物含浸於前述基材片的方法，可例示對乾燥狀態的基材片噴灑水系組成物的方法、利用包含水系組成物的滾筒的塗布方法、浸漬於水系組成物的方法等，但不限定於此等方法。 (3-1) Impregnation of substrate sheet with water-based composition Examples of the method of impregnating the above-mentioned base material sheet with the water-based composition include a method of spraying a dry base material sheet with the water-based composition, a coating method using a roller containing the water-based composition, a method of dipping in the water-based composition, and the like. However, it is not limited to these methods.

在本發明的擦拭片中，水系組成物於基材片的含浸量，從發揮擦拭功能的觀點，相對於基材片的乾燥質量換算100質量份，較佳為100-300質量份，更佳為150-270質量份。若含浸量小於前述100質量份，則不能使水系組成物含浸於基材片整體中，有對擦拭產生干擾之虞，若含浸量超過前述300質量份，則水系組成物無法完全含浸於基材片中，有擦拭後的皮膚濕潤而容易產生不適感之虞。In the wiping sheet of the present invention, the impregnation amount of the water-based composition in the base sheet is preferably 100 to 300 parts by mass, more preferably 100 parts by mass in terms of the dry mass of the base sheet, from the viewpoint of exerting the wiping function. It is 150-270 mass parts. If the amount of impregnation is less than 100 parts by mass, the entire base sheet cannot be impregnated with the water-based composition, which may interfere with wiping. If the amount of impregnation exceeds 300 parts by mass, the entire base sheet cannot be impregnated with the water-based composition. In the sheet, there is a possibility that the skin after wiping is moist and uncomfortable.

(3-2)擦拭片之水相部的pH 本發明的擦拭片中之水相部的pH，亦即使水系組成物含浸於基材片後的幾乎處於平衡狀態之水相部的pH，較佳係在25℃中為6.1以上6.6以下。前述水相部的pH係使用堀場製作所(股)製的LAQUA twin pH計所測定的pH值。 在皮膚表面中，例如為益生菌(Good bacteria)且為皮膚常在菌(Skin-resident bacteria)的表皮葡萄球菌會分泌脂肪酸，且保持皮膚表面為弱酸性以防止雜菌、病毒的入侵。另一方面，若皮膚表面成為鹼性，則為壞菌(Bad bacteria)的金黃色葡萄球菌會變得活躍，有容易產生皮膚問題之虞。 (3-2) pH of the water phase part of the wiping sheet The pH of the water phase portion in the wiping sheet of the present invention, that is, the pH of the water phase portion in an almost equilibrium state after impregnating the base sheet with the water-based composition is preferably 6.1 or more and 6.6 or less at 25°C. The pH of the aqueous phase part is the pH value measured using a LAQUA twin pH meter manufactured by Horiba Corporation. On the skin surface, for example, Staphylococcus epidermidis, which is a good bacteria and a skin-resident bacteria, secretes fatty acids, and keeps the skin surface weakly acidic to prevent the invasion of bacteria and viruses. On the other hand, when the skin surface becomes alkaline, Staphylococcus aureus, which is a bad bacteria, becomes active, and there is a possibility that skin problems are likely to occur.

皮膚表面的pH雖然因人而異，但維持在4.5-6.5左右的弱酸性，成為了益生菌的皮膚常在菌容易棲息的環境。又由於嬰幼兒的皮膚表面的pH在出生後5-6週後成為6.0-7.0左右等，因此較佳為將擦拭片中的水相部的pH維持在上述範圍內。本發明的特徵之一係不添加pH調節劑，藉由抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽的摻合比例，而能將擦拭片中的水相部的pH調節為弱酸性。Although the pH of the skin surface varies from person to person, it is maintained at a weak acidity of around 4.5-6.5, which is an environment where probiotic skin bacteria often inhabit. In addition, since the pH of the skin surface of infants and young children becomes about 6.0 to 7.0 after 5 to 6 weeks after birth, it is preferable to maintain the pH of the water phase portion in the wiping sheet within the above range. One of the features of the present invention is that no pH adjuster is added, and the wiping sheet can be adjusted by the mixing ratio of alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride, which is an antibacterial agent. The pH of the aqueous phase is adjusted to be weakly acidic.

2.關於「擦拭片含浸用之水系組成物」的發明 本發明的「擦拭片含浸用之水系組成物」為一種在純化水中包含：抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、及防霉劑成分之癸酸甘油酯作為保存性提升劑，以及使癸酸甘油酯溶解的溶劑作為助溶劑的擦拭片含浸用之水系組成物， 其特徵係在該水系組成物中，氯化烷基二甲基苄基銨的含量(b1)為0.030質量%以上0.050質量%以下，聚胺基丙基雙胍鹽酸鹽的含量(b2)為0.025質量%以上0.070質量%以下，及癸酸甘油酯的含量(c1)為0.003質量%以上0.050質量%以下， 並且，在該水系組成物中的純化水的濃度為99.85質量%以上99.92質量%以下。 2. Invention of "Aqueous Composition for Impregnation of Wipe Sheets" The "water-based composition for impregnating a wiping sheet" of the present invention is a water-based composition containing, in purified water: alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride, which are antibacterial components, and an antifungal component. The water-based composition for impregnating the wiping sheet with the capric glyceride as a preservation enhancer, and the solvent for dissolving the capric glyceride as a co-solvent, It is characterized in that in the water-based composition, the content (b1) of alkyldimethylbenzylammonium chloride is 0.030 mass % or more and 0.050 mass % or less, and the content (b2) of polyaminopropyl biguanide hydrochloride is 0.025 mass % or more and 0.070 mass % or less, and the content (c1) of capric glyceride is 0.003 mass % or more and 0.050 mass % or less, In addition, the concentration of purified water in the water-based composition is 99.85 mass % or more and 99.92 mass % or less.

以下，將本發明的「水系組成物」分為「(1)純化水、(2)保存性提升劑、(3)助溶劑、(4)水系組成物的pH、(5)其他添加劑、(6)擦拭片含浸用之水系組成物」來進行說明。此外，水系組成物的成分等的構成已在含浸有水系組成物之前述「1.擦拭片」的項目中進行說明。因此，針對水系組成物中的含有成分、摻合量、摻合比例等，只要參照上述「1.擦拭片」項目中的記載內容即可充分理解，因此在本項目中僅作簡要的說明。Hereinafter, the "water-based composition" of the present invention is divided into "(1) purified water, (2) preservation enhancer, (3) cosolvent, (4) pH of the water-based composition, (5) other additives, ( 6) Aqueous composition for impregnation of wiping sheet" will be described. In addition, the structure of the component etc. of an aqueous composition has been demonstrated in the item of the said "1. Wiping sheet" which is impregnated with an aqueous composition. Therefore, the components contained in the water-based composition, the amount of blending, the blending ratio, etc., can be fully understood by referring to the description in the above-mentioned item "1. Wiping sheet", so only a brief description is given in this item.

(1)純化水 水系組成物中使用的純化水係例如較佳為使用自來水等的普通水，視需要在前處理後，藉由組合由離子交換、蒸餾、過濾等手段所選擇之1種或2種以上來進行純化，更佳為進一步藉由紫外線殺菌裝置等來進行殺菌處理。作為水的殺菌處理，可列舉紫外線殺菌、熱殺菌、臭氧水殺菌、氯系殺菌等。藉由上述手段所得的純化水，在純化後、或經純化與殺菌處理後的導電度，較佳係在25℃時為1μS/cm以下。 如後所述，由於水系組成物中的保存性提升劑與助溶劑的含量調整為少量，因此水系組成物中的純化水濃度為99.85質量%以上99.92質量%。 (1) Purified water The purified water system used in the water system composition is preferably ordinary water such as tap water, for example, and after pretreatment as necessary, it is carried out by combining one or more selected from means such as ion exchange, distillation, and filtration. For purification, it is more preferable to further perform sterilization treatment with an ultraviolet sterilizer or the like. As the sterilization treatment of water, ultraviolet sterilization, thermal sterilization, ozone water sterilization, chlorine-based sterilization, etc. are mentioned. The conductivity of the purified water obtained by the above-mentioned means after purification or after purification and sterilization treatment is preferably 1 μS/cm or less at 25°C. As will be described later, the purified water concentration in the water-based composition is 99.85 mass % or more and 99.92 mass % because the contents of the preservability improver and the co-solvent in the water-based composition are adjusted to a small amount.

(2)保存性提升劑 在將擦拭片使用於身體擦拭用的情形下，為了減少對皮膚的刺激，較佳為水系組成物中的純化水的濃度高。另一方面，由於純化水濃度越高的水系組成物，越容易在保存中產生細菌、霉菌，因此會發生保存上的問題。因此，為了儘可能減少水系組成物中的保存性提升劑濃度以減少對皮膚的刺激性，同時使水系組成物含有抗菌劑成分與防霉劑成分而能長期間的保存，保存性提升劑的選擇與其含量的決定是非常重要的。 (2) Preservation enhancer When using the wiping sheet for body wiping, it is preferable that the concentration of purified water in the water-based composition is high in order to reduce irritation to the skin. On the other hand, since the water-system composition with the higher purified water concentration is more likely to generate bacteria and molds during storage, a problem in storage occurs. Therefore, in order to reduce the concentration of the preservative enhancer in the water-based composition as much as possible to reduce irritation to the skin, and at the same time, the water-based composition contains an antibacterial agent component and an antifungal agent component to enable long-term preservation. The decision to choose and its content is very important.

在本水系組成物中，使用了均用於化妝品的抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、及防霉劑成分之癸酸甘油酯作為保存性提升劑。 在本水系組成物中，所謂的「抗菌劑成分」係指主要發揮抗菌性的成分，所謂的「防霉劑成分」係指主要發揮防霉性的成分。 In this water-based composition, alkyl dimethyl benzyl ammonium chloride and polyaminopropyl biguanide hydrochloride, both of which are antibacterial ingredients used in cosmetics, and capric glyceride, which are antifungal ingredients, are used as Preservation enhancer. In this water-based composition, the "antibacterial agent component" refers to a component that mainly exhibits antibacterial properties, and the "antifungal agent component" refers to a component that mainly exhibits antifungal properties.

若抗菌劑成分為僅包含氯化烷基二甲基苄基銨的成分，則有在pH為弱酸性範圍內抗菌性降低之虞，又由於對於該抗菌劑有抗性的菌種的存在等，而有無法充分發揮抗菌效果之虞。因此，由於作為抗菌劑成分較佳為使用至少2成分，所以在水系組成物中，併用氯化烷基二甲基苄基銨、與不易因pH的變化而抗菌性受到影響的聚胺基丙基雙胍鹽酸鹽作為抗菌劑成分。除了藉由該併用可以提高抗菌性外，藉由調整氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽的摻合比例，還能將水系組成物的pH調節為皮膚刺激性少的弱酸性。If the antibacterial agent component is a component containing only alkyldimethylbenzylammonium chloride, the antibacterial properties may be lowered in the weakly acidic pH range, and the presence of bacterial species resistant to the antibacterial agent may occur. , and there is a possibility that the antibacterial effect cannot be fully exerted. Therefore, since it is preferable to use at least two components as the antibacterial agent component, in the aqueous composition, alkyl dimethyl benzyl ammonium chloride and polyamine propylene, which is not easily affected by changes in pH, are used in combination base biguanide hydrochloride as an antibacterial ingredient. In addition to improving the antibacterial properties by this combined use, the pH of the water-based composition can be adjusted to the level of the skin by adjusting the blending ratio of the alkyldimethylbenzylammonium chloride and the polyaminopropyl biguanide hydrochloride. Weak acid with less irritation.

由於在僅選擇抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽這2種作為保存性提升劑的情形下，無法期待充分的防霉性，因此藉由進一步併用防霉劑成分之癸酸甘油酯，除了提高防菌性外，亦可提高防霉性。此外，在水系組成物中含有癸酸甘油酯的情形下，由於該成分對於水溶液的溶解性低，因此需要含有使癸酸甘油酯溶解的溶劑作為助溶劑。 關於水系組成物中所含的氯化烷基二甲基苄基銨、聚胺基丙基雙胍鹽酸鹽、及癸酸甘油酯、及助溶劑的成分的說明，由於與在前述「1.擦拭片」中記載的說明相同，因此在此省略記載。 When only two kinds of antibacterial agent components, alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride, are selected as the preservative enhancers, sufficient antifungal properties cannot be expected. In addition to improving the antibacterial property, the antifungal property can also be improved by using the capric glyceride as an antifungal agent component in combination. In addition, when the aqueous composition contains capric glyceride, since the solubility of this component in an aqueous solution is low, it is necessary to contain a solvent for dissolving capric glyceride as a cosolvent. The description of the components of alkyldimethylbenzylammonium chloride, polyaminopropyl biguanide hydrochloride, capric glyceride, and cosolvent contained in the water-based composition is the same as in the above-mentioned "1. The descriptions described in "Wiping Sheets" are the same, so descriptions are omitted here.

(i)保存性提升劑中各成分的含量 為了減少皮膚刺激性，並且維持高保存性，且為了儘可能減少保存性提升劑的各成分的摻合量，需要如下述般設定其摻合比例。 水系組成物中的抗菌劑成分之氯化烷基二甲基苄基銨的含量(b1)為0.030質量%以上0.050質量%以下，較佳為0.035質量%以上0.050質量%以下。 水系組成物中的抗菌劑成分之聚胺基丙基雙胍鹽酸鹽的含量(b2)為0.025質量%以上0.070質量%以下，較佳為0.035質量%以上0.070質量%以下。聚胺基丙基雙胍鹽酸鹽由於因pH的變化而造成之抗菌性的降低少，所以可以彌補有受到pH變化的影響的可能性之氯化烷基二甲基苄基銨的缺點。 水系組成物中的防霉劑成分之癸酸甘油酯的含量(c1)為0.003質量%以上0.050質量%以下，較佳為0.0035質量%以上0.050質量%以下。 在本發明的水系組成物中，氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、癸酸甘油酯在前述含量中，可分別有效地發揮抗菌性、防霉性。 (i) Content of each component in the preservative enhancer In order to reduce skin irritation and maintain high preservability, and in order to reduce the compounding amount of each component of the preservability improving agent as much as possible, it is necessary to set the compounding ratio as follows. The content (b1) of alkyldimethylbenzylammonium chloride as the antimicrobial component in the water-based composition is 0.030 mass % or more and 0.050 mass % or less, preferably 0.035 mass % or more and 0.050 mass % or less. The content (b2) of the polyaminopropyl biguanide hydrochloride as the antibacterial agent component in the water-based composition is 0.025 mass % or more and 0.070 mass % or less, preferably 0.035 mass % or more and 0.070 mass % or less. Polyaminopropyl biguanide hydrochloride has little reduction in antimicrobial properties due to pH changes, so it can make up for the disadvantage of alkyldimethylbenzylammonium chlorides that may be affected by pH changes. Content (c1) of capric glyceride as the antifungal agent component in the water-based composition is 0.003 mass % or more and 0.050 mass % or less, preferably 0.0035 mass % or more and 0.050 mass % or less. In the water-based composition of the present invention, alkyldimethylbenzylammonium chloride, polyaminopropyl biguanide hydrochloride, and capric glyceride in the aforementioned contents can effectively exert antibacterial properties and antifungal properties, respectively. .

(ii)保存性提升劑中各成分的含有比例 若考慮到本發明的擦拭片的保存性的提升與皮膚刺激性的減少，水系組成物中各成分的含有比例較佳為如下所述。 若考慮到抗菌性的提升，則氯化烷基二甲基苄基銨的含量(b1)與聚胺基丙基雙胍鹽酸鹽的含量(b2)的合計量(b1+b2)較佳為0.06質量%以上0.105質量%以下。若為了減少皮膚刺激性而考慮到水系組成物的pH，則聚胺基丙基雙胍鹽酸鹽的含量(b2)與氯化烷基二甲基苄基銨的含量(b1)的質量比(b2/b1)較佳為0.625以上2.00以下。 又，若考慮到水系組成物的抗菌性與防霉性雙方的提升，防霉劑成分之癸酸甘油酯的含量(c1)、和抗菌劑成分之氯化烷基二甲基苄基銨的含量(b1)與聚胺基丙基雙胍鹽酸鹽的含量(b2)的合計量(b1+b2)的質量比(c1/(b1+b2))，較佳為0.035以上0.833以下。 (ii) Content ratio of each component in the preservative enhancer In consideration of the improvement of the storability of the wiping sheet of the present invention and the reduction of skin irritation, the content ratio of each component in the water-based composition is preferably as follows. Considering the improvement of antibacterial properties, the total amount (b1+b2) of the content (b1) of the alkyl dimethyl benzyl ammonium chloride and the content (b2) of the polyaminopropyl biguanide hydrochloride is preferably 0.06 mass % or more and 0.105 mass % or less. Considering the pH of the water-based composition in order to reduce skin irritation, the mass ratio of the content of polyaminopropyl biguanide hydrochloride (b2) to the content of alkyldimethylbenzylammonium chloride (b1) ( b2/b1) is preferably 0.625 or more and 2.00 or less. Furthermore, considering the improvement of both the antibacterial properties and the antifungal properties of the water-based composition, the content (c1) of glyceryl caprate as the antifungal agent component and the content of alkyldimethylbenzylammonium chloride as the antibacterial agent component. The mass ratio (c1/(b1+b2)) of the total amount (b1+b2) of the content (b1) and the content (b2) of polyaminopropyl biguanide hydrochloride is preferably 0.035 or more and 0.833 or less.

(3)助溶劑 如上所述，由於癸酸甘油酯於水溶液的溶解度非常低，為了使癸酸甘油酯均勻地溶解於水系組成物中，需要含有使癸酸甘油酯溶解的溶劑。作為溶劑，只要能將癸酸甘油酯均勻地溶解水系組成物中即可，沒有特別地限制，但是若考慮到與癸酸甘油酯的溶解性、水溶性、含量、安全性等，較佳為在常溫(15-25℃)中為液狀，而且具有OH末端基的聚醚。前述聚醚之中，若考慮到在常溫為液狀、與刺激性的減少、癸酸甘油酯的溶解性，則更佳係數量平均分子量為100以上600以下的聚乙二醇，進一步較佳係數量平均分子量為200-300的聚乙二醇。 為了維持對於水系組成物的溶解性與防止黏性，及為了將純化水濃度維持於高濃度，水系組成物中的溶劑的含量(d1)與癸酸甘油酯的含量(c1)的質量比(d1/c1)較佳為0.60以上2.14以下。 (3) Cosolvent As described above, since the solubility of capric glyceride in an aqueous solution is very low, it is necessary to contain a solvent for dissolving capric glyceride in order to uniformly dissolve capric glyceride in the aqueous composition. The solvent is not particularly limited as long as it can uniformly dissolve capric glyceride in the water-based composition, but is preferably a solvent in consideration of solubility with capric glyceride, water solubility, content, safety, and the like. A polyether that is liquid at room temperature (15-25°C) and has an OH end group. Among the above-mentioned polyethers, in consideration of being liquid at room temperature, reducing irritation, and solubility of glyceryl caprate, polyethylene glycol having a number average molecular weight of 100 or more and 600 or less is more preferable, and even more preferable Polyethylene glycol with a number average molecular weight of 200-300. In order to maintain the solubility in the water-based composition and prevent stickiness, and to maintain the purified water concentration at a high concentration, the mass ratio of the solvent content (d1) to the capric glyceride content (c1) in the water-based composition ( d1/c1) is preferably 0.60 or more and 2.14 or less.

(4)水系組成物的pH 若考慮到減少對嬰幼兒、老人或肌膚脆弱的病人等的皮膚刺激性等，則在25℃中的水系組成物的pH較佳為3.47-3.83。該水系組成物的pH值係使用堀場製作所(股)製的HORIBA pH METER F-21所得之測定值。水系組成物的pH可藉由聚胺基丙基雙胍鹽酸鹽的含量(b2)與氯化烷基二甲基苄基銨的含量(b1)的質量比(b2/b1)來進行調整。 若使pH在3.47-3.83範圍內的水系組成物含浸於例如由包含聚對苯二甲酸乙二酯纖維與嫘縈纖維的複合纖維等所得之不織布片中，則能將所得之擦拭片中的水相部的pH維持在弱酸性之6.1-6.6左右，能減少以擦拭片擦拭身體時的皮膚刺激。 (4) pH of the aqueous composition The pH of the water-based composition at 25° C. is preferably 3.47 to 3.83 in consideration of reducing skin irritation to infants, the elderly, and patients with fragile skin. The pH value of the water-based composition was measured using HORIBA pH METER F-21 manufactured by Horiba Corporation. The pH of the aqueous composition can be adjusted by the mass ratio (b2/b1) of the content (b2) of the polyaminopropyl biguanide hydrochloride and the content (b1) of the alkyldimethylbenzylammonium chloride. By impregnating a non-woven fabric sheet obtained from, for example, a conjugate fiber containing polyethylene terephthalate fibers and rayon fibers, or the like with an aqueous composition having a pH in the range of 3.47 to 3.83, the resulting wiping sheet can be treated with The pH of the water phase is maintained at about 6.1-6.6 of weak acid, which can reduce skin irritation when wiping the body with the wiper sheet.

(5)其他添加劑 在不損及保存性提升劑的效果之範圍內，水系組成物中亦可含有少量的其他添加劑。作為這樣的添加劑，可列舉具有保濕作用的玻尿酸、膠原蛋白等。 (5) Other additives A small amount of other additives may be contained in the water-based composition within the range that does not impair the effect of the preservative enhancer. Examples of such additives include hyaluronic acid, collagen, and the like having a moisturizing effect.

(6)擦拭片含浸用之水系組成物 本水系組成物係含浸於基材片中作為擦拭片使用。該擦拭片不限定於嬰幼兒臀部擦拭用、病人、老人、嬰幼兒等的身體擦拭用，可進一步廣泛地使用於卸妝用棉片、擦手紙、廚房用擦拭紙巾、OA製品用清潔劑等。 基材片可使用織布或不織布中的任一者，但較佳為使用不織布。作為織布或不織布的材料，可列舉聚丙烯纖維、聚對苯二甲酸乙二酯纖維、聚醯胺纖維、嫘縈纖維、丙烯酸纖維、聚胺基甲酸酯纖維、紙漿纖維(亦包含紙)、及包含此等2種以上的複合纖維，但為了賦予基材片較佳的功能，較佳為使用複合纖維。 (6) Water-based composition for impregnation of wiping sheets This water-based composition is used as a wiping sheet by impregnating a base material sheet. The wiping sheet is not limited to wiping the buttocks of infants, body wiping of patients, the elderly, infants, etc., and can be widely used in cotton pads for makeup removal, toilet paper, kitchen wipes, cleaning agents for OA products, and the like. Either a woven fabric or a non-woven fabric can be used for the base sheet, but a non-woven fabric is preferably used. Examples of woven or non-woven materials include polypropylene fibers, polyethylene terephthalate fibers, polyamide fibers, rayon fibers, acrylic fibers, polyurethane fibers, pulp fibers (including paper ), and these two or more kinds of conjugated fibers are included, but in order to impart a better function to the base sheet, the conjugated fibers are preferably used.

使水系組成物含浸於前述基材片的方法，可例示對乾燥狀態的基材片噴灑水系組成物的方法、利用包含水系組成物的滾筒的塗布方法、浸漬於水系組成物的方法等，但不限定於此等方法。 水系組成物於基材片的含浸量，從發揮擦拭功能的觀點，相對於基材片的乾燥質量換算100質量份，較佳為100-300質量份，更佳為150-270質量份。若含浸量小於前述100質量份，則不能使水系組成物含浸於基材片整體中，有對擦拭產生干擾之虞，若含浸量超過前述300質量份，則水系組成物無法完全含浸於基材片中，有擦拭後的皮膚濕潤而容易產生不適感之虞。 [實施例] As the method of impregnating the above-mentioned base material sheet with the water-based composition, the method of spraying the water-based composition on the dry base material sheet, the coating method using a roller containing the water-based composition, the method of immersing in the water-based composition, etc. can be exemplified. It is not limited to these methods. The impregnation amount of the water-based composition in the base sheet is preferably 100-300 parts by mass, more preferably 150-270 parts by mass, in terms of 100 parts by mass based on the dry mass of the base sheet from the viewpoint of exerting a wiping function. If the amount of impregnation is less than 100 parts by mass, the entire base sheet cannot be impregnated with the water-based composition, which may interfere with wiping. If the amount of impregnation exceeds 300 parts by mass, the entire base sheet cannot be impregnated with the water-based composition. In the sheet, there is a possibility that the skin after wiping is moist and uncomfortable. [Example]

藉由以下的實施例與比較例來具體地說明本發明的擦拭片、及擦拭片含浸用之水系組成物，但是本發明不限定於以下的實施例。在本實施例與比較例中，分為擦拭片含浸用之水系組成物、與含浸有水系組成物的擦拭片來進行說明。The wiping sheet and the water-based composition for impregnating the wiping sheet of the present invention will be specifically described by the following Examples and Comparative Examples, but the present invention is not limited to the following Examples. In this Example and a comparative example, the water-based composition for wiping sheet impregnation and the wiping sheet impregnated with the water-based composition will be described separately.

首先，以下係記載本實施例、比較例中使用的原材料、試料。 (1)純化水 藉由離子交換樹脂純化普通水，製備導電度為1μS/cm以下的純化水。 (2)保存性提升劑、助溶劑 作為添加至水系組成物的成分，使用以下記載的保存性提升劑、助溶劑。此外，pH的測定係使用堀場製作所(股)製的HORIBA pH METER F-21進行。 (i)氯化烷基二甲基苄基銨為市售品，其1質量%水溶液的pH為7.91，10質量%水溶液的pH為8.93。 (ii)聚胺基丙基雙胍鹽酸鹽為市售品，其1質量%水溶液的pH為3.26，10質量%水溶液的pH為3.45，重量平均分子量為2000-3000。 (iii)癸酸甘油酯為市售品，其性狀為蠟狀的塊。此外，該成分由於難溶於水，所以未進行pH測定。 (iv)丁基胺甲酸碘代丙炔酯使用了市售品。 (v)聚乙二醇為市售品，其數量平均分子量為200。 (vi)聚丙二醇使用了市售品。 First, the raw materials and samples used in the present examples and comparative examples are described below. (1) Purified water Ordinary water is purified by ion exchange resin to prepare purified water with a conductivity of 1 μS/cm or less. (2) Preservation enhancer, cosolvent As components to be added to the water-based composition, the following preservative enhancers and cosolvents were used. In addition, the measurement of pH was performed using HORIBA pH METER F-21 by Horiba Corporation. (i) Alkyldimethylbenzylammonium chloride is a commercial item, the pH of the 1 mass % aqueous solution is 7.91, and the pH of the 10 mass % aqueous solution is 8.93. (ii) Polyaminopropyl biguanide hydrochloride is a commercial product, the pH of the 1 mass % aqueous solution is 3.26, the pH of the 10 mass % aqueous solution is 3.45, and the weight average molecular weight is 2000-3000. (iii) Capric glyceride is a commercial item, and its property is a waxy block. In addition, since this component was hardly soluble in water, pH measurement was not performed. (iv) Iodopropynyl butylcarbamate A commercial item was used. (v) Polyethylene glycol is a commercial item, and its number average molecular weight is 200. (vi) A commercial item was used for polypropylene glycol.

(3)基材片 使用於基材片的不織布，係基重為32g/m 2之包含嫘縈纖維與聚對苯二甲酸乙二酯纖維的複合纖維的水針不織布(spunlace)，該複合纖維中的嫘縈纖維的含有比例為40-60質量%。 (3) Base material sheet The non-woven fabric used for the base material sheet is a spunlace of composite fibers containing rayon fibers and polyethylene terephthalate fibers with a basis weight of 32 g/m 2 . The content ratio of the rayon fiber in the fiber is 40-60 mass %.

[實施例1-9、比較例1-8] 1.針對水系組成物的評價試驗 進行針對擦拭片含浸用之水系組成物的評價試驗。 1-1.水系組成物的製備 在實施例1-9、比較例1-8中，製備擦拭片含浸用之水系組成物。 具體而言，根據各實施例與比較例將保存性提升劑與助溶劑以各自的規定量溶解於上述純化水中，而製備表1-3所示的水系組成物。此外，癸酸甘油酯預先溶解於助溶劑之聚乙二醇，並添加至水系組成物中。比較例5中評價的水系組成物由於不包含助溶劑，因此將蠟狀的固態物質磨碎而直接添加至水系組成物中。又，由於比較例8係水系組成物為對照組的例子，因此直接使用上述純化水代替水系組成物。 針對上述製備的水系組成物進行下述的評價。 [Example 1-9, Comparative Example 1-8] 1. Evaluation test for water-based composition An evaluation test for the water-based composition for impregnation of the wiping sheet was performed. 1-1. Preparation of water-based composition In Examples 1-9 and Comparative Examples 1-8, water-based compositions for impregnation of wiping sheets were prepared. Specifically, the water-based compositions shown in Tables 1-3 were prepared by dissolving the preservative improving agent and the cosolvent in the above-mentioned purified water in respective predetermined amounts according to the respective Examples and Comparative Examples. In addition, capric glyceride is dissolved in polyethylene glycol as a co-solvent in advance, and added to the water-based composition. Since the water-based composition evaluated in Comparative Example 5 did not contain a cosolvent, the waxy solid substance was pulverized and directly added to the water-based composition. In addition, since the water-based composition of Comparative Example 8 is an example of a control group, the above-mentioned purified water was used as it was instead of the water-based composition. The following evaluation was performed about the water-system composition prepared above.

1-2.針對水系組成物的評價 在實施例1-9、比較例1-8中，針對製備的水系組成物分別進行(1)pH測定、(2)觀察有無白濁或沉澱物的產生、(3)保存效力試驗。 (1)pH測定 在實施例1-9、比較例1-4、8中，測定所製備的水系組成物在常溫(25℃)下的pH。pH測定裝置係使用堀場製作所(股)製的HORIBA pH METER F-21。 將pH的測定結果示於表1-3中。在實施例1-9的水系組成物中，在常溫(25℃)下的pH在3.47-3.83的範圍。由表1-3，確認到聚胺基丙基雙胍鹽酸鹽的含量(b2)與氯化烷基二甲基苄基銨的含量(b1)的質量比(b2/b1)越增加，則水系組成物的pH值越低。 1-2. Evaluation of water-based compositions In Examples 1-9 and Comparative Examples 1-8, (1) pH measurement, (2) observation of the presence or absence of cloudiness or the occurrence of precipitates, and (3) preservation efficacy test were performed on the prepared aqueous compositions, respectively. (1) pH measurement In Examples 1-9, Comparative Examples 1-4, and 8, the pH of the prepared aqueous compositions at normal temperature (25°C) was measured. The pH measuring apparatus used HORIBA pH METER F-21 by Horiba Corporation. The measurement results of pH are shown in Table 1-3. In the aqueous compositions of Examples 1-9, the pH at normal temperature (25° C.) was in the range of 3.47 to 3.83. From Table 1-3, it was confirmed that the more the mass ratio (b2/b1) of the content (b2) of polyaminopropyl biguanide hydrochloride and the content (b1) of alkyldimethylbenzylammonium chloride increased, the The pH of the aqueous composition is lower.

(2)觀察有無白濁或沉澱物的產生 在實施例1-9、比較例1-7中，將保存性提升劑與助溶劑製備成表1-3所示的濃度，將該水系組成物充分地攪拌後靜置，並用目視觀察有無白濁或沉澱物的產生。將觀察有無白濁或沉澱物的產生之結果示於表1-3。在沒有摻合助溶劑的比較例5中，於水系組成物中觀察到白濁或沉澱的產生。 (2) Observe whether there is white turbidity or sediment In Examples 1-9 and Comparative Examples 1-7, the preservative-improving agent and the co-solvent were prepared to the concentrations shown in Table 1-3, the water-based compositions were sufficiently stirred and then left to stand, and the presence or absence of cloudiness was visually observed. or the formation of sediments. The results of observing the presence or absence of cloudiness or the occurrence of precipitates are shown in Table 1-3. In Comparative Example 5 in which the cosolvent was not blended, cloudiness and precipitation were observed in the aqueous composition.

(3)保存效力試驗 在實施例1-9中，依照第17次修訂的日本藥典(THE JAPANESE PHARMACOPOEIA SEVENTEENTH EDITION)的「保存效力試驗法(Preservatives-Effectiveness Tests)」中記載的試驗法，進行水系組成物的保存效力試驗。該保存效力試驗法在美國藥典中被列為抗菌效力測試(Antimicrobial Effectiveness Testing)，及在歐洲藥典中被列為抗菌保存的功效(Efficacy of antimicrobial preservation)，作為相同類型的試驗方法。 (3) Preservation efficacy test In Examples 1 to 9, the preservation efficacy test of the water-based composition was carried out according to the test method described in "Preservatives-Effectiveness Tests" of the Japanese Pharmacopoeia (THE JAPANESE PHARMACOPOEIA SEVENTEENTH EDITION), 17th revision. . This preservation efficacy test method is listed in the US Pharmacopoeia as Antimicrobial Effectiveness Testing and in the European Pharmacopoeia as Efficacy of antimicrobial preservation as the same type of test method.

(i)試驗方法 保存效力試驗係將一定數量的細菌、真菌分別混入水系組成物中，並隨著時間測定其數量以確認防腐效果的試驗。 分別使用規定為檢測菌株之下述的3種細菌及2種真菌進行接種，並測定7天後、14天後、28天後的生菌數。 抗菌性試驗的檢測菌株(細菌) (a)大腸桿菌(NBRC 3972) (b)金黃色葡萄球菌(NBRC 12732) (c)綠膿桿菌(12689) 抗霉性試驗的檢測菌株(真菌) (d)念珠菌(NBRC 1385) (e)黑麴菌(Aspergillus niger)(NBRC 105649) (i) Test method The preservation efficacy test is a test in which a certain number of bacteria and fungi are mixed into the water system composition, and the number is measured over time to confirm the preservative effect. The following three types of bacteria and two types of fungi, which are defined as test strains, were used for inoculation, respectively, and the number of viable bacteria was measured after 7 days, 14 days, and 28 days. Test strains (bacteria) for the antibacterial test (a) Escherichia coli (NBRC 3972) (b) Staphylococcus aureus (NBRC 12732) (c) Pseudomonas aeruginosa (12689) Test strains (fungi) for the mildew resistance test (d) Candida (NBRC 1385) (e) Aspergillus niger (NBRC 105649)

(ii)評價方法、評價結果 評價係根據接種菌數的減少率而進行。以下顯示減少率的計算方法。 減少率(%)=[((初始菌數)-(7、14、28天後的生菌數))/初始菌數]×100 將針對實施例1-9中製備的水系組成物的評價結果示於表1、2。 此外，在表1、2中，保存效力試驗中的「對照組(7天後)」一欄，表示替代水系組成物而在純化水中接種規定數量的上述細菌、真菌後，於經過7天後的生菌數。 在實施例1-5中，分別於接種細菌、真菌後，測定7天後、14天後、28天後的生菌數，而在實施例6-9中測定7天後的細菌數。 由於在使用任一個上述檢測菌株的保存效力試驗中，7天後及經過7天以後的生菌減少率均為100%，因此確認實施例1-9中製備的水系組成物具有優異的抗菌性･防霉性。 (ii) Evaluation methods and evaluation results The evaluation was performed based on the reduction rate of the number of inoculated bacteria. The calculation method of the reduction rate is shown below. Reduction rate (%)=[((initial number of bacteria)-(number of living bacteria after 7, 14, 28 days))/initial number of bacteria]×100 Tables 1 and 2 show the evaluation results of the aqueous compositions prepared in Examples 1-9. In addition, in Tables 1 and 2, the column of "control group (after 7 days)" in the preservation efficacy test indicates that after inoculating the above-mentioned bacteria and fungi with a predetermined number of the above-mentioned bacteria and fungi in place of the water-based composition in place of the water-based composition, 7 days have passed. the number of bacteria. In Examples 1-5, after inoculation with bacteria and fungi, the number of living bacteria was measured after 7 days, 14 days, and 28 days, respectively, while in Examples 6-9, the number of bacteria after 7 days was measured. In the preservation efficacy test using any of the above-mentioned test strains, the reduction rate of bacteria after 7 days and after 7 days was 100%, so it was confirmed that the water-based compositions prepared in Examples 1-9 had excellent antibacterial properties ･Fungal resistance.

[表1] 實施例1 實施例2 實施例3 實施例4 實施例5 實施例6 1.水系組成物  (1)保存性提升劑   氯化烷基二甲基苄基銨(b1) (質量%) 0.030 0.040 0.045 0.045 0.045 0.040   聚胺基丙基雙胍鹽酸鹽(b2) (質量%) 0.045 0.025 0.040 0.040 0.035 0.035   癸酸甘油酯(c1) (質量%) 0.010 0.010 0.003 0.0035 0.005 0.010   丁基胺甲酸碘代丙炔酯 (質量%) - - - - - -  (2)助溶劑   聚乙二醇(d2) (質量%) 0.010 0.006 0.003 0.003 0.005 0.010   丙二醇 (質量%) - - - - - -  (3)純化水 (質量%) 99.905 99.919 99.909 99.9085 99.910 99.905  (1)-(3)的合計 (質量%) 100.000 100.000 100.000 100.000 100.000 100.000 上述保存性提升劑等的摻合比例   (b1)+(b2) (質量%) 0.075 0.065 0.085 0.085 0.080 0.075   (b2)/(b1) - 1.500 0.625 0.889 0.889 0.778 0.875   (c1)/[(b1)+(b2)] - 0.133 0.154 0.035 0.041 0.063 0.133   (d2)/(c1) - 1.00 0.60 1.00 0.86 1.00 1.00 2.水系組成物的評價結果  (1)水系組成物的pH - 3.55 3.83 3.58 3.56 3.65 3.65  (2)有無白濁或沉澱產生 - 無 無 無 無 無 無  (3)保存效力試驗  (3-1)抗菌性試驗   (i)大腸桿菌 初始菌數 - 2.8×10 5 2.8×10 5 2.2×10 5 2.2×10 5 4.6×10 5 2.8×10 5 對照組(7天後) - 9.8×10 6 9.8×10 6 9.3×10 6 9.3×10 6 1.6×10 6 9.8×10 6 7/14/28天後的生菌數 - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- 生菌減少率 (%) 100 100 100 100 100 100   (ii)金黃色葡萄球菌 初始菌數 - 2.6×10 5 2.6×10 5 3.6×10 5 3.6×10 5 2.4×10 5 2.6×10 5 對照組(7天後) - 1.6×10 5 1.6×10 5 2.2×10 5 2.2×10 5 1.8×10 5 1.6×10 5 7/14/28天後的生菌數 - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- 生菌減少率 (%) 100 100 100 100 100 100   (iii)綠膿桿菌 初始菌數 - 3.1×10 5 3.1×10 5 4.6×10 5 4.6×10 5 3.3×10 5 3.1×10 5 對照組(7天後) - 7.0×10 5 7.0×10 5 2.2×10 6 2.2×10 6 8.8×10 5 7.0×10 5 7/14/28天後的生菌數 - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- 生菌減少率 (%) 100 100 100 100 100 100  (3-2)防霉性試驗   (i)念珠菌 初始菌數 - 5.8×10 5 5.8×10 5 3.3×10 5 3.3×10 5 6.1×10 5 5.8×10 5 對照組(7天後) - 1.4×10 6 1.4×10 6 3.1×10 6 3.1×10 6 1.7×10 6 1.4×10 6 7/14/28天後的生菌數 - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- 生菌減少率 (%) 100 100 100 100 100 100   (ii)黑麴菌 初始菌數 - 1.8×10 5 1.8×10 5 2.2×10 5 2.2×10 5 1.0×10 5 1.8×10 5 對照組(7天後) - 1.3×10 5 1.3×10 5 2.0×10 5 2.0×10 5 1.6×10 5 1.3×10 5 7/14/28天後的生菌數 - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- 生菌減少率 (%) 100 100 100 100 100 100 [Table 1] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 1. Aqueous composition (1) Preservation enhancer Alkyldimethylbenzylammonium chloride (b1) (quality%) 0.030 0.040 0.045 0.045 0.045 0.040 Polyaminopropyl biguanide hydrochloride (b2) (quality%) 0.045 0.025 0.040 0.040 0.035 0.035 Glyceryl Caprate (c1) (quality%) 0.010 0.010 0.003 0.0035 0.005 0.010 Iodopropynyl Butylcarbamate (quality%) - - - - - - (2) Cosolvent polyethylene glycol (d2) (quality%) 0.010 0.006 0.003 0.003 0.005 0.010 Propylene Glycol (quality%) - - - - - - (3) Purified water (quality%) 99.905 99.919 99.909 99.9085 99.910 99.905 Total of (1)-(3) (quality%) 100.000 100.000 100.000 100.000 100.000 100.000 The blending ratio of the above-mentioned preservation enhancer, etc. (b1)+(b2) (quality%) 0.075 0.065 0.085 0.085 0.080 0.075 (b2)/(b1) - 1.500 0.625 0.889 0.889 0.778 0.875 (c1)/[(b1)+(b2)] - 0.133 0.154 0.035 0.041 0.063 0.133 (d2)/(c1) - 1.00 0.60 1.00 0.86 1.00 1.00 2. Evaluation results of water-based compositions (1) pH of the aqueous composition - 3.55 3.83 3.58 3.56 3.65 3.65 (2) Whether there is white turbidity or precipitation - none none none none none none (3) Preservation efficacy test (3-1) Antibacterial test (i) Escherichia coli Initial bacterial count - 2.8×10 5 2.8×10 5 2.2×10 5 2.2×10 5 4.6×10 5 2.8×10 5 Control group (after 7 days) - 9.8×10 6 9.8×10 6 9.3×10 6 9.3×10 6 1.6×10 6 9.8×10 6 The number of bacteria after 7/14/28 days - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- bacteria reduction rate (%) 100 100 100 100 100 100 (ii) Staphylococcus aureus Initial bacterial count - 2.6×10 5 2.6×10 5 3.6×10 5 3.6×10 5 2.4×10 5 2.6×10 5 Control group (after 7 days) - 1.6×10 5 1.6×10 5 2.2×10 5 2.2×10 5 1.8×10 5 1.6×10 5 The number of bacteria after 7/14/28 days - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- bacteria reduction rate (%) 100 100 100 100 100 100 (iii) Pseudomonas aeruginosa Initial bacterial count - 3.1×10 5 3.1×10 5 4.6×10 5 4.6×10 5 3.3×10 5 3.1×10 5 Control group (after 7 days) - 7.0×10 5 7.0×10 5 2.2×10 6 2.2×10 6 8.8×10 5 7.0×10 5 The number of bacteria after 7/14/28 days - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- bacteria reduction rate (%) 100 100 100 100 100 100 (3-2) Mildew resistance test (i) Candida Initial bacterial count - 5.8×10 5 5.8×10 5 3.3×10 5 3.3×10 5 6.1×10 5 5.8×10 5 Control group (after 7 days) - 1.4×10 6 1.4×10 6 3.1×10 6 3.1×10 6 1.7×10 6 1.4×10 6 The number of bacteria after 7/14/28 days - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- bacteria reduction rate (%) 100 100 100 100 100 100 (ii) Nigellae Initial bacterial count - 1.8×10 5 1.8×10 5 2.2×10 5 2.2×10 5 1.0×10 5 1.8×10 5 Control group (after 7 days) - 1.3×10 5 1.3×10 5 2.0×10 5 2.0×10 5 1.6×10 5 1.3×10 5 The number of bacteria after 7/14/28 days - 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/-/- bacteria reduction rate (%) 100 100 100 100 100 100

[表2] 實施例7 實施例8 實施例9 比較例1 比較例2 比較例3 1.水系組成物  (1)保存性提升劑   氯化烷基二甲基苄基銨(b1) (質量%) 0.050 0.035 0.030 0.010 0.030 0.040   聚胺基丙基雙胍鹽酸鹽(b2) (質量%) 0.035 0.070 0.030 0.030 0.010 0.035   癸酸甘油酯(c1) (質量%) 0.007 0.007 0.050 0.007 0.007 -   丁基胺甲酸碘代丙炔酯 (質量%) - - - - - -  (2)助溶劑   聚乙二醇(d2) (質量%) 0.015 0.010 0.040 0.007 0.007 0.004   丙二醇 (質量%) - - - - - -  (3)純化水 (質量%) 99.893 99.878 99.850 99.946 99.946 99.921  (1)-(3)的合計 (質量%) 100.000 100.000 100.000 100.000 100.000 100.000 上述保存性提升劑等的摻合比例   (b1)+(b2) (質量%) 0.085 0.105 0.060 0.040 0.040 0.090   (b2)/(b1) - 0.700 2.000 1.000 3.000 0.333 0.800   (c1)/[(b1)+(b2)] - 0.082 0.067 0.833 0.175 0.175 0.011   (d2)/(c1) - 2.14 1.43 0.80 1.43 1.00 - 2.水系組成物的評價結果  (1)水系組成物的pH - 3.75 3.47 3.77 3.73 4.35 3.71  (2)有無白濁或沉澱產生 - 無 無 無 無 無 無  (3)保存效力試驗  (3-1)抗菌性試驗   (i)大腸桿菌 初始菌數 - 2.8×10 5 2.8×10 5 2.8×10 5 - - - 對照組(7天後) - 9.8×10 6 9.8×10 6 9.8×10 6 - - - 7天後的生菌數 - 0 0 0 - - - 生菌減少率 (%) 100 100 100 - - -   (ii)金黃色葡萄球菌 初始菌數 - 2.6×10 5 2.6×10 5 2.6×10 5 - - - 對照組(7天後) - 1.6×10 5 1.6×10 5 1.6×10 5 - - - 7天後的生菌數 - 0 0 0 - - - 生菌減少率 (%) 100 100 100 - - -   (iii)綠膿桿菌 初始菌數 - 3.1×10 5 3.1×10 5 3.1×10 5 - - - 對照組(7天後) - 7.0×10 5 7.0×10 5 7.0×10 5 - - - 7天後的生菌數 - 0 0 0 - - - 生菌減少率 (%) 100 100 100 - - -  (3-2)防霉性試驗 - - -   (i)念珠菌 初始菌數 - 5.8×10 5 5.8×10 5 5.8×10 5 - - - 對照組(7天後) - 1.4×10 6 1.4×10 6 1.4×10 6 - - - 7天後的生菌數 - 0 0 0 - - - 生菌減少率 (%) 100 100 100 - - -   (ii)黑麴菌 初始菌數 - 1.8×10 5 1.8×10 5 1.8×10 5 - - - 對照組(7天後) - 1.3×10 5 1.3×10 5 1.3×10 5 - - - 7天後的生菌數 - 0 0 0 - - - 生菌減少率 (%) 100 100 100 - - - [Table 2] Example 7 Example 8 Example 9 Comparative Example 1 Comparative Example 2 Comparative Example 3 1. Aqueous composition (1) Preservation enhancer Alkyldimethylbenzylammonium chloride (b1) (quality%) 0.050 0.035 0.030 0.010 0.030 0.040 Polyaminopropyl biguanide hydrochloride (b2) (quality%) 0.035 0.070 0.030 0.030 0.010 0.035 Glyceryl Caprate (c1) (quality%) 0.007 0.007 0.050 0.007 0.007 - Iodopropynyl Butylcarbamate (quality%) - - - - - - (2) Cosolvent polyethylene glycol (d2) (quality%) 0.015 0.010 0.040 0.007 0.007 0.004 Propylene Glycol (quality%) - - - - - - (3) Purified water (quality%) 99.893 99.878 99.850 99.946 99.946 99.921 Total of (1)-(3) (quality%) 100.000 100.000 100.000 100.000 100.000 100.000 The blending ratio of the above-mentioned preservation enhancer, etc. (b1)+(b2) (quality%) 0.085 0.105 0.060 0.040 0.040 0.090 (b2)/(b1) - 0.700 2.000 1.000 3.000 0.333 0.800 (c1)/[(b1)+(b2)] - 0.082 0.067 0.833 0.175 0.175 0.011 (d2)/(c1) - 2.14 1.43 0.80 1.43 1.00 - 2. Evaluation results of water-based compositions (1) pH of the aqueous composition - 3.75 3.47 3.77 3.73 4.35 3.71 (2) Whether there is white turbidity or precipitation - none none none none none none (3) Preservation efficacy test (3-1) Antibacterial test (i) Escherichia coli Initial bacterial count - 2.8×10 5 2.8×10 5 2.8×10 5 - - - Control group (after 7 days) - 9.8×10 6 9.8×10 6 9.8×10 6 - - - The number of bacteria after 7 days - 0 0 0 - - - bacteria reduction rate (%) 100 100 100 - - - (ii) Staphylococcus aureus Initial bacterial count - 2.6×10 5 2.6×10 5 2.6×10 5 - - - Control group (after 7 days) - 1.6×10 5 1.6×10 5 1.6×10 5 - - - The number of bacteria after 7 days - 0 0 0 - - - bacteria reduction rate (%) 100 100 100 - - - (iii) Pseudomonas aeruginosa Initial bacterial count - 3.1×10 5 3.1×10 5 3.1×10 5 - - - Control group (after 7 days) - 7.0×10 5 7.0×10 5 7.0×10 5 - - - The number of bacteria after 7 days - 0 0 0 - - - bacteria reduction rate (%) 100 100 100 - - - (3-2) Mildew resistance test - - - (i) Candida Initial bacterial count - 5.8×10 5 5.8×10 5 5.8×10 5 - - - Control group (after 7 days) - 1.4×10 6 1.4×10 6 1.4×10 6 - - - The number of bacteria after 7 days - 0 0 0 - - - bacteria reduction rate (%) 100 100 100 - - - (ii) Nigellae Initial bacterial count - 1.8×10 5 1.8×10 5 1.8×10 5 - - - Control group (after 7 days) - 1.3×10 5 1.3×10 5 1.3×10 5 - - - The number of bacteria after 7 days - 0 0 0 - - - bacteria reduction rate (%) 100 100 100 - - -

[表3] 比較例4 比較例5 比較例6 比較例7 比較例8 1.水系組成物  (1)保存性提升劑   氯化烷基二甲基苄基銨(b1) (質量%) 0.030 0.045 0.050 0.2500 -   聚胺基丙基雙胍鹽酸鹽(b2) (質量%) 0.030 0.035 0.100 - -   癸酸甘油酯(c1) (質量%) - 0.007 - - -   丁基胺甲酸碘代丙炔酯 (質量%) - - - 0.2500 -  (2)助溶劑   聚乙二醇(d2) (質量%) 0.004 - - - -   丙二醇 (質量%) - - - 0.0225 -  (3)純化水 (質量%) 99.936 99.913 99.850 99.4755 100.000  (1)-(3)的合計 (質量%) 100.000 100.000 100.000 100.0000 100.000 上述保存性提升劑等的摻合比例   (b1)+(b2) (質量%) 0.060 0.075 0.105 - -   (b2)/(b1) - 1.000 0.078 2.000 - -   (c1)/[(b1)+(b2)] - - 0.088 - - -   (d2)/(c1) - - - - - - 2.水系組成物的評價結果  (1)水系組成物的pH - - - - - 6.08  (2)有無白濁或沉澱產生 - 無 有 無 無 - [table 3] Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 1. Aqueous composition (1) Preservation enhancer Alkyldimethylbenzylammonium chloride (b1) (quality%) 0.030 0.045 0.050 0.2500 - Polyaminopropyl biguanide hydrochloride (b2) (quality%) 0.030 0.035 0.100 - - Glyceryl Caprate (c1) (quality%) - 0.007 - - - Iodopropynyl Butylcarbamate (quality%) - - - 0.2500 - (2) Cosolvent polyethylene glycol (d2) (quality%) 0.004 - - - - Propylene Glycol (quality%) - - - 0.0225 - (3) Purified water (quality%) 99.936 99.913 99.850 99.4755 100.000 Total of (1)-(3) (quality%) 100.000 100.000 100.000 100.0000 100.000 The blending ratio of the above-mentioned preservation enhancer, etc. (b1)+(b2) (quality%) 0.060 0.075 0.105 - - (b2)/(b1) - 1.000 0.078 2.000 - - (c1)/[(b1)+(b2)] - - 0.088 - - - (d2)/(c1) - - - - - - 2. Evaluation results of water-based compositions (1) pH of the aqueous composition - - - - - 6.08 (2) Whether there is white turbidity or precipitation - none Have none none -

2.針對擦拭片的評價試驗、及結果 將實施例1-9、比較例1-4、6、7中製備的水系組成物含浸於基材片中以製備擦拭片試驗片，並針對所得之擦拭片試驗片，進行了以下的關於保存穩定性試驗與皮膚刺激性的評價。 (i)保存穩定性試驗 作為保存穩定性試驗，進行了抗菌性試驗、抗霉性試驗、及霉菌抗性試驗。 此外，針對擦拭片試驗片的抗霉性的評價，實施例1-4中，為了明確相對於比較例的優越性，進行了定量的抗霉性評價的抗霉性試驗。又，實施例5-9中，由於假設相對於比較例的優越性，因此進行了定性的抗霉性評價的霉菌抗性試驗。 (ii)關於皮膚刺激性的評價 作為關於皮膚刺激性試驗的評價，進行了擦拭片試驗片的水相部的pH測定、及初級皮膚刺激性試驗。 2. Evaluation test and results for wiping sheets The water-based compositions prepared in Examples 1-9 and Comparative Examples 1-4, 6, and 7 were impregnated into substrate sheets to prepare wiping sheet test pieces, and the following preservation was performed for the obtained wiping sheet test pieces. Stability test and evaluation of skin irritation. (i) Storage stability test As a storage stability test, an antibacterial test, a mold resistance test, and a mold resistance test were performed. In addition, regarding the evaluation of the mildew resistance of the wipe-off test piece, in Examples 1-4, in order to clarify the superiority with respect to the comparative example, the mildew resistance test of quantitative mildew resistance evaluation was performed. In addition, in Examples 5-9, since the superiority with respect to a comparative example was assumed, the mold resistance test of the qualitative mold resistance evaluation was performed. (ii) Evaluation on skin irritation As evaluation regarding the skin irritation test, pH measurement of the water phase portion of the wipe test piece, and a primary skin irritation test were performed.

2-1.擦拭片試驗片的製作 將上述製備的水系組成物，用手動噴霧，以含浸量成為80g/m 2左右的方式均勻地噴灑至裁切成規定尺寸的上述不織布片上，製作實施例1-9、及比較例1-4、6-8中分別要評價的擦拭片試驗片。此外，使水系組成物含浸於不織布片後，藉由紫外線進行了殺菌處理。 2-1. Preparation of wiping sheet test piece The water-based composition prepared above was sprayed by hand to uniformly spray the above-mentioned non-woven fabric sheet cut into a predetermined size so that the impregnation amount was about 80 g/m 2 to prepare an example. 1-9, and Comparative Examples 1-4 and 6-8 are the wiping sheet test pieces to be evaluated, respectively. In addition, after impregnating the non-woven fabric sheet with the water-based composition, sterilization treatment was performed by ultraviolet rays.

2-2.針對擦拭片試驗片的評價試驗 (1)擦拭片試驗片的水相部的pH測定 將實施例1-9、比較例1-4、8中製備的水系組成物分別含浸於基材片以製作擦拭片試驗片後，放置了約60分鐘。然後，將用浸軋加工機(輾壓機)擰壓該擦拭片試驗片而得的萃取液維持在室溫(25℃)，使用pH測定裝置(堀場製作所(股)製的LAQUA twin pH計)進行了pH測定。將測定結果示於表4-6。 含浸有實施例1-9中製備的水系組成物之擦拭片試驗片的水相部的pH均在6.1-6.6的範圍內。 2-2. Evaluation test for wiping sheet test pieces (1) pH measurement of the water phase part of the wiping sheet test piece After the water-based compositions prepared in Examples 1-9, Comparative Examples 1-4, and 8 were respectively impregnated into the base material sheet to prepare a wiping sheet test piece, it was left to stand for about 60 minutes. Then, the extract obtained by twisting the wiper test piece with a padding machine (roller) was maintained at room temperature (25° C.), and a pH measuring device (LAQUA twin pH meter manufactured by Horiba, Ltd.) was used. ) were measured for pH. The measurement results are shown in Table 4-6. The pH of the water phase part of the wiping piece test piece impregnated with the water-based composition prepared in Examples 1-9 was all within the range of 6.1-6.6.

(2)抗菌性試驗 針對將實施例1-9、比較例1-4、6-8中用於評價而製備的水系組成物分別含浸於基材片所得之擦拭片試驗片，依照JIS L 1902(2015)，進行了定性試驗的抗菌性試驗。 JIS L 1902係針對「纖維製品的抗菌性試驗方法及抗菌效果(Textiles-Determination of antibacterial activity and efficacy of textile products)」所規定的日本產業規格。JIS L 1902係根據ISO 20743(2013年發行)所制定的規格，針對包含不織布的全部抗菌性纖維製品的抗菌活性的評價方法進行規定。 (2) Antibacterial test The wiping sheet test pieces obtained by impregnating the substrate sheets with the water-based compositions prepared for evaluation in Examples 1-9, Comparative Examples 1-4, and 6-8, respectively, were tested in accordance with JIS L 1902 (2015). Antibacterial test for qualitative test. JIS L 1902 is a Japanese industrial standard prescribed for "Textiles-Determination of antibacterial activity and efficacy of textile products". JIS L 1902 specifies a method for evaluating the antibacterial activity of all antibacterial fiber products including non-woven fabrics based on the standards established by ISO 20743 (issued in 2013).

(i)試驗的方法 供試細菌使用下述的2種。 大腸桿菌(NBRC 3301) 金黃色葡萄球菌(NBRC 12732) 將在洋菜培養基中分別加入了大腸桿菌、金黃色葡萄球菌所得之培養基放入培養皿中並使其硬化，並在前述培養皿的中央放置擦拭片試驗片。將該培養皿在37℃放置48小時，於細菌在培養基上繁殖的狀態下，測定在試驗片的周圍沒有細菌繁殖的抑制帶(抑菌圈(halo))形成寬度的四邊的寬度(mm)，並求得其平均值。此外，在表6中，僅針對比較例6、7，記載了抑菌圈的有無作為評價結果。 (i) Method of testing The following two kinds of test bacteria were used. Escherichia coli (NBRC 3301) Staphylococcus aureus (NBRC 12732) A culture medium obtained by adding Escherichia coli and Staphylococcus aureus to the agar medium, respectively, was put into a petri dish and hardened, and a swab test piece was placed in the center of the petri dish. The petri dish was left at 37°C for 48 hours, and in the state where bacteria were propagated on the medium, the width (mm) of the four sides of the formation width of the inhibition zone (halo) without bacterial growth around the test piece was measured. , and find its average value. In addition, in Table 6, only for Comparative Examples 6 and 7, the presence or absence of a bacteriostatic zone is described as an evaluation result.

(ii)評價結果 將針對試驗菌之大腸桿菌與金黃色葡萄球菌測定的抑菌圈寬度示於表4-6。 根據JIS L 1902之有無抑菌圈的判定基準係如下所示。 抑菌圈的寬度平均值＞0時：有抑菌圈 抑菌圈的寬度平均值=0時：無抑菌圈 在實施例1至9中，抗菌性試驗的評價均為「有抑菌圈」的判定。 (ii) Evaluation results The width of the inhibition zone measured against the test bacteria Escherichia coli and Staphylococcus aureus is shown in Table 4-6. The criteria for determining the presence or absence of a zone of inhibition according to JIS L 1902 are as follows. When the average width of the inhibition zone is greater than 0: there is an inhibition zone When the average width of the inhibition zone = 0: no inhibition zone In Examples 1 to 9, the evaluation of the antibacterial property test was all judged as "there is a zone of inhibition".

(3)抗霉性試驗 針對將實施例1-4、比較例4中製備的水系組成物分別含浸於前述基材片所得之擦拭片試驗片，依照JIS L 1921(2015)進行了抗霉性試驗。抗霉性試驗是檢驗在比較短的時間內滅絕一定數量霉菌的抗霉力之定量的試驗方法。此外，JIS L 1921是針對「纖維製品的抗霉性試驗方法及抗霉效果(Textiles-Determination of antifungal activity and efficacy of textile products)」所規定的日本產業規格。JIS L 1921是根據ISO 13629-1(2012年發行)所制定的規格。 (3) Mildew resistance test The antifungal test was performed according to JIS L 1921 (2015) with respect to the wiping sheet test pieces obtained by impregnating the aforementioned substrate sheets with the water-based compositions prepared in Examples 1-4 and Comparative Example 4, respectively. The mildew resistance test is a quantitative test method to examine the mildew resistance of a certain number of molds in a relatively short period of time. In addition, JIS L 1921 is a Japanese industrial standard prescribed for "Textiles-Determination of antifungal activity and efficacy of textile products". JIS L 1921 is a specification based on ISO 13629-1 (issued in 2012).

(i)試驗的概要 從預先培養的試驗霉菌採取胞子，以製備試驗用胞子懸浮液。接著，將該試驗胞子懸浮液分別接種於擦拭片試驗片、與比較對照試料(棉標準布)上，藉由測定在25℃培養18、24小時後的ATP量，而測定在試料上生存的霉菌量。藉由比較擦拭片試驗片與對照試料的霉菌量，算出表示能抑制多少霉菌增殖的「抗霉活性值」。此外，所謂ATP量的測定係指藉由酵素等使在生物的細胞內存在的ATP(三磷酸腺苷)發光，並測定其發光量。該發光量係細胞內的ATP量越多越會增加。 (i) Outline of the test Spores were taken from pre-cultured test molds to prepare a spore suspension for the test. Next, the test cell suspension was inoculated on the wiper test piece and the comparative control sample (cotton standard cloth), respectively, and the amount of ATP that survived on the samples was measured by measuring the amount of ATP after 18 and 24 hours of incubation at 25°C. fungal amount. The "anti-mold activity value" indicating how much the growth of the mold can be suppressed was calculated by comparing the amount of mold in the wiping sheet test piece and the control sample. In addition, the measurement of the amount of ATP means that ATP (adenosine triphosphate) existing in the cells of a living organism is made to emit light by an enzyme or the like, and the light emission amount is measured. This luminescence amount increases as the amount of ATP in the cell increases.

「抗霉活性值」係由下式求得。 抗霉活性值(Aa)：(Fb-Fa)-(Fc-Fo) Fb：未經處理的棉纖維培養42小時後的ATP量的算術平均的常用對數值 Fa：未經處理的棉纖維剛接種之後的ATP量的算術平均的常用對數值 Fc：擦拭片試驗片培養42小時後的ATP量的算術平均的常用對數值 Fo：擦拭片試驗片剛接種之後的ATP量的算術平均的常用對數值 The "antifungal activity value" was obtained by the following formula. Antifungal activity value (Aa): (Fb-Fa)-(Fc-Fo) Fb: common logarithmic value of the arithmetic mean of the ATP amount after 42 hours of culture in untreated cotton fibers Fa: common logarithmic value of the arithmetic mean of the amount of ATP immediately after inoculation of untreated cotton fibers Fc: common logarithmic value of the arithmetic mean of the ATP amount after 42 hours of incubation of the swab test piece Fo: common logarithmic value of the arithmetic mean of the amount of ATP immediately after inoculation of the wiper test piece

(ii)試驗霉菌種 選擇下述的霉菌作為試驗霉菌種。 黑麴菌(NBRC 105649) (iii)評價基準、評價結果 抗霉活性值(Aa)數值越大，表示抗霉性能越高，從評價基準來看，2.0以上具有抗霉性。 將實施例1-4、比較例4中算出的抗霉活性值(Aa)示於表4。從表4確認了實施例1-4的擦拭片試驗片係抗霉活性值(Aa)均為2.0以上，與比較例4的擦拭片試驗片相比，抗霉性優異。 (ii) Test mold species The following molds were selected as test mold species. Black yeast yeast (NBRC 105649) (iii) Evaluation criteria and evaluation results The larger the value of the antifungal activity value (Aa), the higher the antifungal performance, and from the evaluation criteria, 2.0 or more has antifungal properties. Table 4 shows the antifungal activity values (Aa) calculated in Examples 1-4 and Comparative Example 4. From Table 4, it was confirmed that the antifungal activity values (Aa) of the wiping sheet test pieces of Examples 1-4 were all 2.0 or more, and were superior to the wiping sheet test pieces of Comparative Example 4 in antifungal properties.

(4)霉菌抗性試驗 針對將前述水系組成物分別含浸於基材片所得之擦拭片試驗片，根據霉菌抗性試驗(JIS Z 2911(2018))進行了評價。該「霉菌抗性試驗方法(Methods of test for fungus resistance)」是評價試驗片對於霉菌的抗性之定性的試驗，可以在比較長的培養期間進行試驗片的霉菌抗性的評價。 此外，JIS Z 2911是根據ISO 846(1997年發行)、IEC 60068-2-10(2005年發行)、及ISO 9022-11(2015年發行)所制定的日本產業規格。 (4) Fungal resistance test The wiping sheet test pieces obtained by impregnating the substrate sheet with the aforementioned water-based composition, respectively, were evaluated according to the mold resistance test (JIS Z 2911 (2018)). The "Methods of test for fungus resistance" is a qualitative test for evaluating the resistance of a test piece to a mold, and the evaluation of the mold resistance of the test piece can be performed during a relatively long incubation period. In addition, JIS Z 2911 is a Japanese industrial standard established in accordance with ISO 846 (issued in 1997), IEC 60068-2-10 (issued in 2005), and ISO 9022-11 (issued in 2015).

(i)試驗的概要 針對將實施例5-9、比較例1-3、8中用於評價而製備的水系組成物分別含浸於基材片所得之擦拭片試驗片，進行了霉菌抗性試驗。 此外，在上述實施例1-4、比較例4中，由於在上述抗霉性試驗中已評價了抗霉性，因此省略了霉菌抗性試驗。 將試驗片放置在培養皿內的無機鹽培養基上，對試驗片的表面均勻地噴吹下述霉菌的胞子懸浮液，並在28±4℃培養4週後，用肉眼及顯微鏡觀察在前述試驗片上的菌絲發育狀態。 (i) Outline of the test The mold resistance test was performed on the wiping sheet test pieces obtained by impregnating the substrate sheets with the water-based compositions prepared for evaluation in Examples 5-9, Comparative Examples 1-3, and 8, respectively. In addition, in the said Example 1-4 and the comparative example 4, since the mold resistance was evaluated in the said mold resistance test, the mold resistance test was abbreviate|omitted. Place the test piece on the inorganic salt medium in the petri dish, spray the spore suspension of the following mold on the surface of the test piece evenly, and after culturing at 28±4°C for 4 weeks, observe with the naked eye and microscope The state of mycelium development on the slice.

(ii)供試霉菌 使用下述的(a)1種霉菌、與(b)3種混合霉菌。 (a)黑麴菌(Aspergillus niger) NBRC 105649 (b)混合3種 桔青黴(Penicillium citrinum) (NBRC 6352) 球毛殼菌(Chaetomium globosum) (NBRC 6347) 疣孢菌(Myrothecium verrucaria) (NBRC 6113) (ii) Test mold The following (a) one type of mold and (b) three types of mixed mold were used. (a) Aspergillus niger NBRC 105649 (b) Mix 3 kinds Penicillium citrinum (NBRC 6352) Chaetomium globosum (NBRC 6347) Myrothecium verrucaria (NBRC 6113)

(iii)判定基準、評價結果 根據JIS Z 2911(2018)，霉菌發育狀態的判定基準係以下述的3階段表示，「0或1」的評價為具有霉菌抗性。 0：在試驗片的經接種的部分沒有觀察到菌絲的發育。 1：在試驗片的經接種的部分被觀察到的菌絲的面積未超過全部面積的1/3。 2：在試驗片的經接種的部分被觀察到的菌絲的面積超過了全部面積的1/3。 根據上述判定基準，將評價結果示於表4-6。從表4-6，確認了在實施例5-9中製作的擦拭片試驗片中，霉菌發育狀態的判定均為1，與比較例1-3、8中製作的擦拭片試驗片相比，霉菌抗性優異。 (iii) Judgment criteria and evaluation results According to JIS Z 2911 (2018), the criteria for determining the growth state of mold are expressed in the following three stages, and the evaluation of "0 or 1" indicates that the mold has mold resistance. 0: No development of mycelium was observed in the inoculated portion of the test piece. 1: The area of the mycelium observed in the inoculated part of the test piece did not exceed 1/3 of the entire area. 2: The area of hyphae observed in the inoculated portion of the test piece exceeded 1/3 of the entire area. The evaluation results are shown in Table 4-6 based on the above-mentioned criteria. From Table 4-6, it was confirmed that in the wiping sheet test pieces produced in Examples 5-9, the determination of the mold growth state was 1, and compared with the wiping sheet test pieces produced in Comparative Examples 1-3 and 8, the Excellent mold resistance.

[表4] 實施例1 實施例2 實施例3 實施例4 比較例4 1.水系組成物  (1)保存性提升劑   氯化烷基二甲基苄基銨(b1) (質量%) 0.030 0.040 0.045 0.045 0.030   聚胺基丙基雙胍鹽酸鹽(b2) (質量%) 0.045 0.025 0.040 0.040 0.030   癸酸甘油酯(c1) (質量%) 0.010 0.010 0.003 0.0035 -   丁基胺甲酸碘代丙炔酯 (質量%) - - - - -  (2)助溶劑   聚乙二醇(d2) (質量%) 0.010 0.006 0.003 0.003 0.004   丙二醇 (質量%) - - - - -  (3)純化水 (質量%) 99.905 99.919 99.909 99.9085 99.936  (1)-(3)的合計 (質量%) 100.000 100.000 100.000 100.0000 100.000 2.擦拭片的評價 (1)水相部的pH - 6.3 6.6 6.6 6.5 6.4 (2)抗菌性評價試驗   48小時後的抑菌圈寬度     供試菌：大腸桿菌 (mm) 0.1 0.1 0.1 0.1 0.1     供試菌：金黃色葡萄球菌 (mm) 2 2 2 2 3 (3)抗霉性試驗   試驗霉菌種：黑麴菌     培養18小時後的抗霉活性值(Aa) - 4.4 4.4 4.4 3.3 1.2     培養42小時後的抗霉活性值(Aa) - 3.6 3.5 4.3 4.3 1.3 [Table 4] Example 1 Example 2 Example 3 Example 4 Comparative Example 4 1. Aqueous composition (1) Preservation enhancer Alkyldimethylbenzylammonium chloride (b1) (quality%) 0.030 0.040 0.045 0.045 0.030 Polyaminopropyl biguanide hydrochloride (b2) (quality%) 0.045 0.025 0.040 0.040 0.030 Glyceryl Caprate (c1) (quality%) 0.010 0.010 0.003 0.0035 - Iodopropynyl Butylcarbamate (quality%) - - - - - (2) Cosolvent polyethylene glycol (d2) (quality%) 0.010 0.006 0.003 0.003 0.004 Propylene Glycol (quality%) - - - - - (3) Purified water (quality%) 99.905 99.919 99.909 99.9085 99.936 Total of (1)-(3) (quality%) 100.000 100.000 100.000 100.0000 100.000 2. Evaluation of wiping sheets (1) pH of the aqueous phase - 6.3 6.6 6.6 6.5 6.4 (2) Antibacterial evaluation test Width of the zone of inhibition after 48 hours Tested bacteria: Escherichia coli (mm) 0.1 0.1 0.1 0.1 0.1 Test bacteria: Staphylococcus aureus (mm) 2 2 2 2 3 (3) Mildew resistance test Test mold species: Nigella Antifungal activity value (Aa) after 18 hours of culture - 4.4 4.4 4.4 3.3 1.2 Antifungal activity value (Aa) after 42 hours of culture - 3.6 3.5 4.3 4.3 1.3

[表5] 實施例5 實施例6 實施例7 實施例8 實施例9 1.水系組成物  (1)保存性提升劑   氯化烷基二甲基苄基銨(b1) (質量%) 0.045 0.040 0.050 0.035 0.030   聚胺基丙基雙胍鹽酸鹽(b2) (質量%) 0.035 0.035 0.035 0.070 0.030   癸酸甘油酯(c1) (質量%) 0.005 0.010 0.007 0.007 0.050   丁基胺甲酸碘代丙炔酯 (質量%) - - - - -  (2)助溶劑   聚乙二醇(d2) (質量%) 0.005 0.010 0.015 0.010 0.040   丙二醇 (質量%) - - - - -  (3)純化水 (質量%) 99.910 99.905 99.893 99.878 99.850  (1)-(3)的合計 (質量%) 100.000 100.000 100.000 100.000 100.000 2.擦拭片的評價 (1)水相部的pH - 6.5 6.4 6.6 6.1 6.4 (2)抗菌性評價試驗   48小時後的抑菌圈寬度     供試菌：大腸桿菌 (mm) 0.5 0.3 0.3 0.3 0.3     供試菌：金黃色葡萄球菌 (mm) 3 2 3 2 2 (4)霉菌抗性試驗   根據JIS Z 2911的判定基準     供試霉菌：黑麴菌   培養4週後 - 1 1 1 1 1     供試霉菌：3種混合   培養4週後 - 1 1 1 1 1 [table 5] Example 5 Example 6 Example 7 Example 8 Example 9 1. Aqueous composition (1) Preservation enhancer Alkyldimethylbenzylammonium chloride (b1) (quality%) 0.045 0.040 0.050 0.035 0.030 Polyaminopropyl biguanide hydrochloride (b2) (quality%) 0.035 0.035 0.035 0.070 0.030 Glyceryl Caprate (c1) (quality%) 0.005 0.010 0.007 0.007 0.050 Iodopropynyl Butylcarbamate (quality%) - - - - - (2) Cosolvent polyethylene glycol (d2) (quality%) 0.005 0.010 0.015 0.010 0.040 Propylene Glycol (quality%) - - - - - (3) Purified water (quality%) 99.910 99.905 99.893 99.878 99.850 Total of (1)-(3) (quality%) 100.000 100.000 100.000 100.000 100.000 2. Evaluation of wiping sheets (1) pH of the aqueous phase - 6.5 6.4 6.6 6.1 6.4 (2) Antibacterial evaluation test Width of the zone of inhibition after 48 hours Tested bacteria: Escherichia coli (mm) 0.5 0.3 0.3 0.3 0.3 Test bacteria: Staphylococcus aureus (mm) 3 2 3 2 2 (4) Fungal resistance test Judgment standard according to JIS Z 2911 Tested mold: Nigella After 4 weeks of culture - 1 1 1 1 1 Tested mold: 3 kinds of mixed After 4 weeks of culture - 1 1 1 1 1

[表6] 比較例1 比較例2 比較例3 比較例5 比較例6 比較例7 比較例8 1.水系組成物  (1)保存性提升劑   氯化烷基二甲基苄基銨(b1) (質量%) 0.010 0.030 0.040 0.045 0.0500 0.2500 -   聚胺基丙基雙胍鹽酸鹽(b2) (質量%) 0.030 0.010 0.035 0.035 0.1000 - -   癸酸甘油酯(c1) (質量%) 0.007 0.007 - 0.007 - - -   丁基胺甲酸碘代丙炔酯 (質量%) - - - - - 0.2500 -  (2)助溶劑   聚乙二醇(d2) (質量%) 0.007 0.007 0.004 - - - -   丙二醇 (質量%) - - - - - 0.0225 -  (3)純化水 (質量%) 99.946 99.946 99.921 99.913 99.8500 99.4755 100.000  (1)-(3)的合計 (質量%) 100.000 100.000 100.000 100.000 100.0000 100.0000 100.000 2.擦拭片的評價 (1)水相部的pH - 5.8 6.9 6.4 - - - 7.1 (2)抗菌性評價試驗   48小時後的抑菌圈寬度     供試菌：大腸桿菌 (mm) 0.1 0.1 0.3 - 有抑菌圈 有抑菌圈 0     供試菌：金黃色葡萄球菌 (mm) 1 1 3 - 有抑菌圈 有抑菌圈 0 (4)霉菌抗性試驗   根據JIS Z 2911的判定基準     供試霉菌：黑麴菌   培養4週後 - 2 2 1 - - - 2     供試霉菌：3種混合   培養4週後 - 2 2 2 - - - 2 [Table 6] Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 1. Aqueous composition (1) Preservation enhancer Alkyldimethylbenzylammonium chloride (b1) (quality%) 0.010 0.030 0.040 0.045 0.0500 0.2500 - Polyaminopropyl biguanide hydrochloride (b2) (quality%) 0.030 0.010 0.035 0.035 0.1000 - - Glyceryl Caprate (c1) (quality%) 0.007 0.007 - 0.007 - - - Iodopropynyl Butylcarbamate (quality%) - - - - - 0.2500 - (2) Cosolvent polyethylene glycol (d2) (quality%) 0.007 0.007 0.004 - - - - Propylene Glycol (quality%) - - - - - 0.0225 - (3) Purified water (quality%) 99.946 99.946 99.921 99.913 99.8500 99.4755 100.000 Total of (1)-(3) (quality%) 100.000 100.000 100.000 100.000 100.0000 100.0000 100.000 2. Evaluation of wiping sheets (1) pH of the aqueous phase - 5.8 6.9 6.4 - - - 7.1 (2) Antibacterial evaluation test Width of the zone of inhibition after 48 hours Tested bacteria: Escherichia coli (mm) 0.1 0.1 0.3 - There is a zone of inhibition There is a zone of inhibition 0 Test bacteria: Staphylococcus aureus (mm) 1 1 3 - There is a zone of inhibition There is a zone of inhibition 0 (4) Fungal resistance test Judgment standard according to JIS Z 2911 Tested mold: Nigella After 4 weeks of culture - 2 2 1 - - - 2 Tested mold: 3 kinds of mixed After 4 weeks of culture - 2 2 2 - - - 2

(5)初級皮膚刺激性試驗 進行了依照日本化妝品工業協會(Japan Cosmetic Industry Association)所制定的「關於化妝品安全性評價的指南(Guidelines for the Safety Evaluation of Cosmetics)」之初級皮膚刺激性試驗(Primary skin irritation test)。 針對下述擦拭片試驗片，進行了初級皮膚刺激性試驗，其中該擦拭片試驗片為：在含浸實施例6中用於評價而製備的水系組成物所製作的擦拭片試驗片、及實施例6中製備的水系組成物中，使除了氯化烷基二甲基苄基銨設為0.0500質量%、聚胺基丙基雙胍鹽酸鹽設為0.0500質量%、癸酸甘油酯設為0.0300質量%、聚乙二醇設為0.0100質量%以外，與實施例6中所製備者相同的水系組成物(實施例11)含浸而製作的擦拭片試驗片。 (5) Primary skin irritation test A primary skin irritation test was performed in accordance with "Guidelines for the Safety Evaluation of Cosmetics" established by the Japan Cosmetic Industry Association. The primary skin irritation test was performed on the following wiping sheet test pieces prepared by impregnating the water-based composition prepared for evaluation in Example 6, and Examples In the water-based composition prepared in step 6, except that alkyldimethylbenzylammonium chloride was set to 0.0500 mass %, polyaminopropyl biguanide hydrochloride was set to 0.0500 mass %, and capric glyceride was set to 0.0300 mass % A wiping piece test piece prepared by impregnating the same water-based composition (Example 11) as that prepared in Example 6 except that the polyethylene glycol was set to 0.0100% by mass.

(i)試驗方法 對於健康的男性與女性的受試者20名，將皮膚測試用帶(評價用擦拭片試驗片)貼附在受試者的背部正常皮膚部。在貼附24小時後，取下皮膚測試用帶並以目視確認皮膚的症狀，並依下述評價基準進行評價。 無反應：0.0點 輕微的紅斑：0.5點 明顯的紅斑：1.0點 紅斑及浮腫或丘疹：2.0點 紅斑及浮腫/丘疹及小水疱：3.0點 大水疱：4.0點 (i) Test method For 20 healthy male and female test subjects, a skin test tape (a wiping sheet test piece for evaluation) was attached to the normal skin portion of the back of the test subject. After 24 hours of sticking, the skin test tape was removed, and the symptoms of the skin were visually confirmed and evaluated according to the following evaluation criteria. No response: 0.0 points Slight erythema: 0.5 points Significant erythema: 1.0 points Erythema and puffiness or papules: 2.0 points Erythema and puffiness/papules and small blisters: 3.0 points Large blisters: 4.0 points

(ii)皮膚刺激指數與判定 求得各受試者的評價點數，並藉由下式求得皮膚刺激指數。 皮膚刺激指數=(評分總和/受試者人數)×100 接著，從所得的皮膚刺激指數，根據香妝品的皮膚刺激指數的分類(安全品：5.0以下，容許品：5.0-15.0，要改良品：15.0-30.0，危險品：30.0以上)來判定安全性。 評價的結果，實施例6、11中製作的擦拭片試驗片的皮膚刺激指數均顯示為2.5以下，被分類為「安全品」。 (ii) Skin irritation index and determination The evaluation points of each test subject were obtained, and the skin irritation index was obtained by the following formula. Skin irritation index=(sum of scores/number of subjects)×100 Next, from the obtained skin irritation index, safety is determined according to the classification of the skin irritation index of fragrances (safety product: 5.0 or less, permissible product: 5.0-15.0, improved product: 15.0-30.0, dangerous product: 30.0 or more). sex. As a result of the evaluation, the wiping sheet test pieces produced in Examples 6 and 11 both showed a skin irritation index of 2.5 or less, and were classified as "safety products".

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Claims (15)

一種擦拭片，其係在由織布或不織布構成的基材片中含浸有包含保存性提升劑與助溶劑的水系組成物而成之擦拭片， 其特徵係該水系組成物在純化水中包含： 抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、及防霉劑成分之癸酸甘油酯作為保存性提升劑， 以及使癸酸甘油酯溶解的溶劑作為助溶劑， 在該水系組成物中，氯化烷基二甲基苄基銨的含量(b1)為0.030質量%以上0.050質量%以下， 聚胺基丙基雙胍鹽酸鹽的含量(b2)為0.025質量%以上0.070質量%以下， 癸酸甘油酯的含量(c1)為0.003質量%以上0.050質量%以下， 並且，在該水系組成物中，純化水的濃度為99.85質量%以上99.92質量%以下。 A wiping sheet, which is a wiping sheet formed by impregnating a substrate sheet consisting of a woven cloth or a non-woven cloth with an aqueous composition comprising a preservation enhancer and a cosolvent, characterized in that the aqueous composition contains in purified water: Alkyl dimethyl benzyl ammonium chloride and polyaminopropyl biguanide hydrochloride, which are antibacterial agents, and capric glyceride, which are antifungal agents, are used as preservation enhancers. and a solvent that dissolves glyceryl caprate as a cosolvent, In this water-based composition, the content (b1) of alkyldimethylbenzylammonium chloride is 0.030 mass % or more and 0.050 mass % or less, The content (b2) of polyaminopropyl biguanide hydrochloride is 0.025 mass % or more and 0.070 mass % or less, The content (c1) of capric glyceride is 0.003 mass % or more and 0.050 mass % or less, In addition, in this water-based composition, the concentration of purified water is 99.85 mass % or more and 99.92 mass % or less. 如請求項1之擦拭片，其中在該水系組成物中，氯化烷基二甲基苄基銨的含量(b1)與聚胺基丙基雙胍鹽酸鹽的含量(b2)的合計量(b1+b2)為0.060質量%以上0.105質量%以下，且聚胺基丙基雙胍鹽酸鹽的含量(b2)與氯化烷基二甲基苄基銨的含量(b1)的質量比(b2/b1)為0.625以上2.00以下。The wiping sheet according to claim 1, wherein in the water-based composition, the total amount of the content (b1) of alkyldimethylbenzylammonium chloride and the content of polyaminopropyl biguanide hydrochloride (b2) is ( b1+b2) is 0.060 mass % or more and 0.105 mass % or less, and the mass ratio (b2) of the content (b2) of polyaminopropyl biguanide hydrochloride to the content (b1) of alkyldimethylbenzylammonium chloride /b1) is 0.625 or more and 2.00 or less. 如請求項1之擦拭片，其中在該水系組成物中，防霉劑成分之癸酸甘油酯的含量(c1)、和抗菌劑成分之氯化烷基二甲基苄基銨的含量(b1)與聚胺基丙基雙胍鹽酸鹽的含量(b2)的合計量(b1+b2)的質量比(c1/(b1+b2))為0.035以上0.833以下。The wiping sheet according to claim 1, wherein in the water-based composition, the content (c1) of glyceryl caprate as an antifungal agent component and the content (b1) of alkyldimethylbenzylammonium chloride as an antibacterial agent component ) and the content (b2) of polyaminopropyl biguanide hydrochloride and the mass ratio (c1/(b1+b2)) of the total amount (b1+b2) is 0.035 or more and 0.833 or less. 如請求項1之擦拭片，其中在該水系組成物中，使癸酸甘油酯溶解的溶劑的含量(d1)、與防霉劑成分之癸酸甘油酯的含量(c1)的質量比(d1/c1)為0.60以上2.14以下。The wiping sheet according to claim 1, wherein in the water-based composition, the mass ratio (d1) of the content (d1) of the solvent for dissolving glyceryl caprate to the content (c1) of glyceryl caprate as the antifungal agent component /c1) is 0.60 or more and 2.14 or less. 如請求項1之擦拭片，其中在該水系組成物中，使癸酸甘油酯溶解的溶劑係在常溫之15-25℃中為液狀，並且具有OH末端基的聚醚。The wiping sheet of claim 1, wherein in the aqueous composition, the solvent for dissolving glyceryl caprate is a polyether that is liquid at 15-25° C. at room temperature and has an OH terminal group. 如請求項1之擦拭片，其中在該水系組成物中，使癸酸甘油酯溶解的溶劑係數量平均分子量100以上600以下的聚乙二醇。The wiping sheet according to claim 1, wherein the water-based composition contains polyethylene glycol having a number-average molecular weight of 100 or more and 600 or less as a solvent for dissolving capric glyceride. 如請求項1之擦拭片，其中該擦拭片中的水相部在25℃的pH為6.1以上6.6以下。The wiping sheet according to claim 1, wherein the pH of the water phase portion in the wiping sheet at 25°C is 6.1 or more and 6.6 or less. 如請求項1之擦拭片，其中該擦拭片係嬰幼兒臀部擦拭用、或是病人、老人、或嬰幼兒的身體擦拭用的擦拭片。The wiping sheet of claim 1, wherein the wiping sheet is a wiping sheet for wiping the buttocks of infants, or for wiping the body of a patient, the elderly, or an infant. 一種擦拭片含浸用之水系組成物，其係在純化水中包含：抗菌劑成分之氯化烷基二甲基苄基銨與聚胺基丙基雙胍鹽酸鹽、及防霉劑成分之癸酸甘油酯作為保存性提升劑， 以及使癸酸甘油酯溶解的溶劑作為助溶劑之擦拭片含浸用之水系組成物， 其特徵係在該水系組成物中，氯化烷基二甲基苄基銨的含量(b1)為0.030質量%以上0.050質量%以下，聚胺基丙基雙胍鹽酸鹽的含量(b2)為0.025質量%以上0.070質量%以下，及癸酸甘油酯的含量(c1)為0.003質量%以上0.050質量%以下， 並且在該水系組成物中，純化水的濃度為99.85質量%以上99.92質量%以下。 A water-based composition for impregnating a wiper sheet, comprising in purified water: alkyldimethylbenzylammonium chloride and polyaminopropyl biguanide hydrochloride as antibacterial agents, and capric acid as antifungal agent Aqueous composition for impregnating wiping sheets with glyceride as a preservative enhancer, and a solvent for dissolving capric glyceride as a cosolvent, It is characterized in that in the water-based composition, the content (b1) of alkyldimethylbenzylammonium chloride is 0.030 mass % or more and 0.050 mass % or less, and the content (b2) of polyaminopropyl biguanide hydrochloride is 0.025 mass % or more and 0.070 mass % or less, and the content (c1) of capric glyceride is 0.003 mass % or more and 0.050 mass % or less, And in this water system composition, the density|concentration of purified water is 99.85 mass % or more and 99.92 mass % or less. 如請求項9之擦拭片含浸用之水系組成物，其中在該水系組成物中，氯化烷基二甲基苄基銨的含量(b1)與聚胺基丙基雙胍鹽酸鹽的含量(b2)的合計量(b1+b2)為0.060質量%以上0.105質量%以下， 而且，聚胺基丙基雙胍鹽酸鹽的含量(b2)與氯化烷基二甲基苄基銨的含量(b1)的質量比(b2/b1)為0.625以上2.00以下。 The water-based composition for impregnation of a wiper sheet according to claim 9, wherein in the water-based composition, the content (b1) of alkyldimethylbenzylammonium chloride and the content of polyaminopropyl biguanide hydrochloride ( The total amount (b1+b2) of b2) is 0.060 mass % or more and 0.105 mass % or less, Moreover, the mass ratio (b2/b1) of the content (b2) of the polyaminopropyl biguanide hydrochloride and the content (b1) of the alkyldimethylbenzylammonium chloride is 0.625 or more and 2.00 or less. 如請求項9之擦拭片含浸用之水系組成物，其中在該水系組成物中，防霉劑成分之癸酸甘油酯的含量(c1)、和抗菌劑成分之氯化烷基二甲基苄基銨的含量(b1)與聚胺基丙基雙胍鹽酸鹽的含量(b2)的合計量(b1+b2)的質量比(c1/(b1+b2))為0.035以上0.833以下。The water-based composition for impregnation of the wiping sheet according to claim 9, wherein in the water-based composition, the content (c1) of glyceryl caprate as an antifungal agent component, and alkyl dimethyl benzyl chloride as an antibacterial agent component The mass ratio (c1/(b1+b2)) of the total amount (b1+b2) of the content (b1) of the base ammonium and the content (b2) of the polyaminopropyl biguanide hydrochloride is 0.035 or more and 0.833 or less. 如請求項9之擦拭片含浸用之水系組成物，其中在該水系組成物中，使癸酸甘油酯溶解的溶劑的含量(d1)、與防霉劑成分之癸酸甘油酯的含量(c1)的質量比(d1/c1)為0.60以上2.14以下。The water-based composition for impregnation of the wiping sheet according to claim 9, wherein in the water-based composition, the content (d1) of the solvent for dissolving capric glyceride and the content (c1) of the antifungal agent component of capric glyceride ) mass ratio (d1/c1) of 0.60 or more and 2.14 or less. 如請求項9之擦拭片含浸用之水系組成物，其中該水系組成物在25℃中的pH為3.47以上3.83以下。The water-based composition for impregnation of the wiping sheet according to claim 9, wherein the pH of the water-based composition at 25° C. is 3.47 or more and 3.83 or less. 如請求項9之擦拭片含浸用之水系組成物，其中該使癸酸甘油酯溶解的溶劑係在常溫之15-25℃中為液狀，並且具有OH末端基的聚醚。The water-based composition for impregnation of the wiping sheet according to claim 9, wherein the solvent for dissolving capric glyceride is a polyether that is liquid at 15-25° C. at room temperature and has an OH terminal group. 如請求項9之擦拭片含浸用之水系組成物，其中該使癸酸甘油酯溶解的溶劑係數量平均分子量100以上600以下的聚乙二醇。The water-based composition for impregnation of the wiping sheet according to claim 9, wherein the solvent-based polyethylene glycol having a number-average molecular weight of 100 or more and 600 or less as a solvent for dissolving glyceryl caprate.
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