TW201900140A - Radioisotope separation device - Google Patents

Abstract

The present invention provides a radioisotope component separation device capable of appropriately separating a component containing a radioisotope from a liquid containing a radioisotope, and capable of inhibiting impurities from being mixed with the separated component. The radioisotope component separation device (1) includes: a solid phase extraction column (11) capable of adsorbing a radioisotope component in a solution; a treatment liquid storage portion (16) used as a liquid extract storage portion; a disposable liquid extract supply flow path configured to supply a liquid extract to the solid phase extraction column; a first storage portion (12) and a second storage portion (13) configured to store the liquid from the solid phase extraction column (11); a first disposable discharge flow path connected to the solid phase extraction column (11) and the first storage portion (12); a second disposable discharge flow path connected to the solid phase extraction column (11) and the second storage portion (13); a sensor (18) used as a measurement unit for measuring the amount of radiation of the liquid discharged from the solid phase extraction column (11); and a flow path switching unit (19) configured to switch the flow path of the liquid discharged from the solid phase extraction column (11) based on the measurement result.

Description

放射性同位素成分分離裝置Radioisotope component separation device

本申請主張根據2017年5月30日申請之日本專利申請第2017-107005號的優先權。該申請的所有內容藉由參閱被援用於本說明書中。 　　本發明係關於一種放射性同位素成分分離裝置。This application claims priority based on Japanese Patent Application No. 2017-107005 filed on May 30, 2017. The entire contents of that application are incorporated herein by reference. The present invention relates to a radioisotope component separation device.

作為從放射性藥劑合成裝置等獲得之反應液中分離含有放射性同位素的特定成分的方法，在專利文獻1中示出使用了固相萃取管柱(SPE)的裝置。又，在專利文獻2中示出使用了高效液相層析法(HPLC)的裝置。 (先前技術文獻) (專利文獻) 　　專利文獻1：日本特開2012-181146號公報 　　專利文獻2：日本特開2006-38644號公報As a method for separating a specific component containing a radioisotope from a reaction liquid obtained from a radiopharmaceutical synthesis device or the like, Patent Document 1 shows an apparatus using a solid phase extraction tube column (SPE). In addition, Patent Document 2 shows an apparatus using a high performance liquid chromatography (HPLC) method. (Prior Art Document) (Patent Document) Patent Document 1: Japanese Patent Laid-Open No. 2012-181146 Patent Document 2: Japanese Patent Laid-Open No. 2006-38644

(發明所欲解決之問題) 　　然而，專利文獻1之裝置，有時難以將含有放射性同位素的成分與其他的成分分離。另一方面，專利文獻2之裝置，雖然能夠適當地進行含有放射性同位素的成分的分離，但從裝置的結構上考慮，存在雜質混入到分離後的成分中的風險。 　　本發明係鑑於上述問題而開發完成者，其目的為提供一種放射性同位素成分分離裝置，能夠從含有放射性同位素的液體中適當地分離含有放射性同位素的成分，且能夠抑制雜質混入到分離後的成分中。 (解決問題之技術手段) 　　為了實現上述目的，有關本發明的一形態之放射性同位素成分分離裝置，係溶液中的放射性同位素成分的分離裝置，其具有：固相萃取管柱，能夠吸附前述溶液中的放射性同位素成分；萃取液儲存部，儲存萃取液，該萃取液能夠使被吸附於前述固相萃取管柱之前述放射性同位素成分脫離；用後即棄式萃取液供給流路，向固相萃取管柱供給儲存於前述萃取液儲存部的前述萃取液；第1儲存部，儲存來自前述固相萃取管柱的液體；第2儲存部，儲存來自前述固相萃取管柱的液體；用後即棄式第1排出流路，連接前述固相萃取管柱和前述第1儲存部；用後即棄式第2排出流路，連接前述固相萃取管柱和前述第2儲存部；測定部，在前述固相萃取管柱的下游側，測定從前述固相萃取管柱排出之液體的放射線量；及流路切換部，根據前述測定部的測定結果，將從前述固相萃取管柱排出之液體的流路在前述第1排出流路和前述第2排出流路之間切換。 　　依據上述放射性同位素成分分離裝置，根據測定部的測定結果，在第1排出流路和第2排出流路之間切換流路，藉此能夠在其中一方的儲存部中適當地回收放射性同位素成分。又，由於將有可能流向回收放射性同位素成分的儲存部的流路設為用後即棄式，能夠抑制雜質混入到所回收之放射性同位素成分中。 　　在此，能夠設為如下態樣：前述固相萃取管柱由能夠吸附相異成分的複數個管柱構成，前述第2儲存部包含複數個容器，前述流路切換部，係根據前述測定部的測定結果，將從前述固相萃取管柱排出之液體的流路在前述第1排出流路和前述第2排出流路之間切換，並且從前述複數個容器中選擇儲存從前述固相萃取管柱排出之液體的容器。 　　上述態樣中，固相萃取管柱由能夠吸附相異成分的複數個管柱構成，根據測定部的測定結果，流路切換部從第2儲存部中所包含之複數個容器中選擇儲存從固相萃取管柱排出之液體的容器。藉由設為這種結構，能夠將溶液中的複數種RI化合物個別回收。 (發明之效果) 　　依據本發明，提供一種放射性同位素成分分離裝置，能夠從含有放射性同位素的液體中適當地分離含有放射性同位素的成分，且能夠抑制雜質混入到分離後的成分中。(Problems to be Solved by the Invention) However, in the device of Patent Document 1, it is sometimes difficult to separate a component containing a radioisotope from other components. On the other hand, although the device of Patent Document 2 can properly separate components containing radioisotopes, there is a risk that impurities are mixed into the separated components in consideration of the structure of the device. The present invention has been developed in view of the above problems, and an object thereof is to provide a radioisotope component separation device capable of appropriately separating a radioisotope-containing component from a radioisotope-containing liquid, and capable of suppressing impurities from being mixed into the separated component . (Technical means to solve the problem) In order to achieve the above-mentioned object, a radioisotope component separation device according to one aspect of the present invention is a radioisotope component separation device in a solution, which includes a solid-phase extraction tube column capable of adsorbing the aforementioned solution. The radioisotope component of the extraction solution storage section stores the extraction solution, which can dissociate the radioisotope component adsorbed on the solid-phase extraction tube column; the disposable extraction liquid supply flow path is used for solid-phase extraction The column supplies the extraction solution stored in the extraction solution storage section; the first storage section stores the liquid from the solid phase extraction tube column; the second storage section stores the liquid from the solid phase extraction tube column; immediately after use The disposable first discharge flow path is connected to the solid phase extraction string and the first storage section; the disposable second discharge flow path is used to connect the solid phase extraction string and the second storage section; the measurement section, The radiation amount of the liquid discharged from the solid-phase extraction string is measured on the downstream side of the solid-phase extraction string; The measurement result of the flow channel portion, from the solid phase extraction column of the liquid discharge switching between the first discharge passage and the second discharge passage. According to the radioisotope component separation device described above, the radioisotope component can be appropriately recovered in one of the storage sections by switching the flow path between the first discharge flow path and the second discharge flow path based on the measurement result of the measurement section. In addition, since the flow path that may flow to the storage portion where the radioisotope component is recovered is a disposable type, it is possible to suppress impurities from being mixed into the recovered radioisotope component. Here, it can be set as follows: the solid phase extraction column is composed of a plurality of columns capable of adsorbing dissimilar components, the second storage section includes a plurality of containers, and the flow path switching section is based on the measurement section. As a result of the measurement, the flow path of the liquid discharged from the solid phase extraction column is switched between the first discharge flow path and the second discharge flow path, and the solid phase extraction is selected from the plurality of containers for storage. A container for liquid discharged from a column. In the above aspect, the solid-phase extraction column is composed of a plurality of columns capable of adsorbing dissimilar components. Based on the measurement result of the measurement section, the flow path switching section selects and stores from a plurality of containers included in the second storage section. A container for liquid discharged from a solid phase extraction column. With such a structure, a plurality of RI compounds in the solution can be individually recovered. (Effects of the Invention) According to the present invention, there is provided a radioisotope component separation device capable of appropriately separating a radioisotope-containing component from a liquid containing the radioisotope, and suppressing impurities from being mixed into the separated component.

以下，參閱附圖對本實施方式進行詳細說明。此外，在附圖的說明中，對相同的要件標註相同的符號，並省略重複說明。 　　圖1係有關本發明的一實施形態之放射性同位素成分分離裝置的概略結構圖。圖1所示之放射性同位素成分分離裝置1係從反應液分離放射性同位素標誌化合物(RI化合物)的裝置，該反應液含有讓放射性元素同位素(RI)與既定的原料試劑進行化學反應而得之RI化合物。本實施形態中，將放射性同位素標誌化合物稱為“放射性同位素成分”。 　　反應液係在RI化合物合成裝置中製造之溶液。又，RI化合物用於例如在醫院等的PET檢查(正子發射斷層攝影檢查)等所使用之放射性藥劑(包括放射性藥物)的製造中。 　　如圖1所示，放射性同位素成分分離裝置1具有：固相萃取管柱11，能夠捕集RI；第1儲存部12及第2儲存部13，儲存從固相萃取管柱11排出之液體；反應液儲存部14，向固相萃取管柱11供給反應液；處理液儲存部15及處理液儲存部16，向固相萃取管柱11供給複數種處理液；送液用注射器17；感測器18；及流路切換部19。 　　固相萃取管柱11係具有利用固相萃取(Solid Phase Extraction：SPE)來分離RI化合物的功能之管柱。具體而言，固相萃取管柱11係填充有能夠吸附RI化合物的粒子(樹脂粒子等)的管柱。粒子並無特別限定，只要能夠特異性吸附作為對象的RI化合物即可。又，亦可以根據反應液的特性等來選擇填充於固相萃取管柱11的粒子。本實施形態中，針對固相萃取管柱11為1段結構，且只分離回收既定的RI化合物之情況進行了說明，但亦可以將固相萃取管柱11設為由能夠吸附相異成分的複數個管柱構成之複數段結構。此外，固相萃取管柱11係預想限單次使用的用後即棄式管柱。 　　處理液係指在向固相萃取管柱11導入反應液之前，向固相萃取管柱11導入的液體，或指在向固相萃取管柱11導入反應液之後，向固相萃取管柱11導入的液體。作為處理液，例如可以舉出：從固相萃取管柱11內的樹脂中將RI化合物脫離(分離)後向固相萃取管柱11的下游排出之萃取液。除此以外，用於清洗固相萃取管柱11內的樹脂的清洗液等也包括在處理液內。本實施形態中，針對如下情況進行說明：作為處理液儲存部具有處理液儲存部15、處理液儲存部16這兩者，在處理液儲存部15中儲存有清洗液，並且在處理液儲存部16中儲存有萃取液。亦即，處理液儲存部16發揮萃取液儲存部的功能。但是，依RI化合物的分離回收步驟中所需之處理液的種類，適當地變更其數量。 　　第1儲存部12及第2儲存部13具有儲存從固相萃取管柱11排出之液體的功能。本實施形態中，針對如下情況進行說明：第1儲存部12發揮所謂廢液容器的功能，第2儲存部13發揮回收RI化合物的回收容器的功能。有關本實施形態之放射性同位素成分分離裝置1，回收對象係含有RI化合物的成分，因此，含有RI化合物的液體從固相萃取管柱11排出時，在第2儲存部13回收該液體。另一方面，在第1儲存部12回收不含有RI化合物的液體。此外，本實施形態中示出儲存部為2個之情況，但在回收複數個成分之情況下，亦能夠將回收用第2儲存部13設為複數個(複數個容器)。 　　在固相萃取管柱11的上游側，在反應液儲存部14和固相萃取管柱11之間依序連接有管路L1、閥V1及管路L2。管路L1、閥V1及管路L2發揮本實施形態之溶液供給流路的功能。溶液供給流路係用後即棄式流路。又，管路L1等的流路例如由矽管等構成。 　　又，來自處理液儲存部15、處理液儲存部16的管路L3、管路L4在閥V2匯合，匯合後之管路L5與閥V1連接。在管路L5上，透過閥V3設置有送液用注射器17。送液用注射器17具有控制流過處理液側的管路L5的液體的流速的功能，但亦可以使用蠕動泵(Peristaltic pump)等來代替送液用注射器17。管路L3、管路L4、閥V2、管路L5及閥V3發揮本實施形態之處理液供給流路的功能。本實施形態中，萃取液被儲存於處理液儲存部16，因此，從處理液儲存部16至固相萃取管柱11的管路L4、閥V2、管路L5及閥V3發揮本實施形態之萃取液供給流路的功能。包括萃取液供給流路的處理液供給流路係用後即棄式流路。 　　在固相萃取管柱11的上游側，藉由切換閥V1及閥V2來選擇向固相萃取管柱11供給的液體。又，藉由控制閥V3來控制從處理液儲存部15、處理液儲存部16向固相萃取管柱11供給的處理液的流速。 　　在固相萃取管柱11的下游側，在固相萃取管柱11和第1儲存部12之間依序連接有管路L6、閥V4及管路L7。管路L6、閥V4及管路L7發揮本實施形態之第1排出流路的功能。第1排出流路係用後即棄式流路。 　　又，在閥V4連接著管路L8，在管路L8的下游側設置有第2儲存部13。管路L6、閥V4及該管路L8發揮本實施形態之第2排出流路的功能。第2排出流路係用後即棄式流路。此外，管路L6及閥V4具有作為第1排出流路及第2排出流路的功能。 　　在放射性同位素成分分離裝置1，由流路切換部19進行閥V4的控制。流路切換部19藉由感測器18來檢測流過管路L6內的從固相萃取管柱11排出之液體的放射線，並且根據該結果，進行閥V4的控制所致之流路的變更。感測器18發揮測定流過流路的液體的放射線強度的放射線測定部的功能。此外，作為感測器18，例如能夠使用放射線檢測器。 　　具體而言，感測器18所檢測之放射線的強度在既定的閾值以上之情況下，將閥V4控制成使從固相萃取管柱11排出之液體經由第2排出流路儲存於第2儲存部13。另一方面，感測器18所檢測之放射線的強度比既定的閾值小之情況下，將閥V4控制成使從固相萃取管柱11排出之液體經由第1排出流路儲存於第1儲存部12。藉由流路切換部19進行上述的控制，放射線強度成為既定閾值以上，亦即，能夠在第2儲存部13選擇性地回收含有RI化合物之液體。 　　接著，參閱圖2針對使用有關本實施形態之放射性同位素成分分離裝置1之放射性同位素的分離方法進行說明。 　　首先，將在RI化合物合成裝置等獲得之反應液經由作為溶液供給流路的管路L1及管路L2供給至固相萃取管柱11，藉由固相萃取管柱11的樹脂捕集RI化合物(S01)。 　　接著，藉由使送液用注射器17動作，將儲存於處理液儲存部15的清洗液經由管路L3、L5及L2供給至固相萃取管柱11。然後，藉由清洗液清洗固相萃取管柱11的樹脂(S02)。 　　接著，藉由使送液用注射器17動作，將儲存於處理液儲存部16的萃取液經由管路L4、L5及L2供給(導入)至固相萃取管柱11。又，在導入萃取液的同時，開始利用發揮測定部的功能之感測器18測定從固相萃取管柱排出之液體的放射線強度(S03)。同時，在流路切換部19取得感測器18的測定結果，開始有關流路切換的控制。 　　在流路切換部19，判定感測器18的測定值(感測器值)是否為閾值以上(S04)。而且，測定值為小於閾值之情況(S04-NO)下，不進行流路的變更，繼續進行利用感測器18的測定。另一方面，測定值為閾值以上之情況(S04-YES)下，流路切換部19將流路切換為第2排出流路。亦即，將來自固相萃取管柱11的流路的連接對象變更為第2儲存部13(S05)。 　　將來自固相萃取管柱11的流路的連接對象變更為第2儲存部13之後，繼續進行利用感測器18的測定及利用流路切換部19的有關流路切換的控制。亦即，在流路切換部19，判定感測器18的測定值(感測器值)是否小於閾值(S06)。而且，測定值為閾值以上之情況(S06-NO)下，不進行流路的變更，繼續進行利用感測器18的測定。另一方面，測定值小於閾值之情況(S06-YES)下，流路切換部19將流路切換為第1排出流路。亦即，將來自固相萃取管柱11的流路的連接對象變更為第1儲存部12(S07)。藉此，只有感測器值為閾值以上的液體被回收至第2儲存部13。 　　如上所述，有關本實施形態之放射性同位素成分分離裝置中，能夠在第2儲存部13中適當地回收含有放射性同位素的成分。又，將有可能流向回收含有放射性同位素的成分的第2儲存部13的管路及閥設為用後即棄式，能夠抑制雜質的混入等。 　　以往的放射性藥劑的製造步驟中，作為回收在合成裝置等所合成之放射性同位素的方法，探討了使用固相萃取管柱的方法和使用HPLC的方法。然而，無論哪種方法，在放射性藥劑的製造步驟中的RI化合物的分離回收方面仍有改善的空間。首先，在使用一般的固相萃取管柱的方法中，對於吸附於管柱內的樹脂之RI化合物，係使用萃取液使RI化合物從樹脂中脫離並回收。然而，以往的使用了固相萃取管柱的方法中，未進行分離回收含有特定的成分之液體的操作。因此，並未進行只分離並回收含有特定的成分之液體。 　　另一方面，相較於固相萃取管柱，使用HPLC的方法在分離回收含有特定成分的液體時分離性能提高是已知的。然而，HPLC具有向成分分離用的管柱以高壓導入液體的特徵，裝置結構等亦複雜。又，對於成分分離用的管柱，亦以使用複數次為前提。因此，存在如下問題：難以將在放射性藥劑中使用之放射性同位素的流路設為用後即棄式，難以確保分離回收之RI化合物的清淨性。 　　相對於此，依據有關本實施形態之放射性同位素成分分離裝置1，利用感測器18監測從固相萃取管柱11排出之液體的放射線量，若偵測到放射線量高的液體排出，則藉由流路切換部19將流路切換成使回收液體的對象成為第2儲存部13。藉由設為這樣的結構，即使在使用固相萃取管柱11之情況下，仍能夠只分離並回收放射線量高的含有特定的成分的液體。又，在放射性同位素成分分離裝置1，將在放射性藥劑中使用之放射性同位素的流路，亦即反應液供給流路、處理液供給流路(包括萃取液供給流路)、第1排出流路及第2排出流路設為由用後即棄式材料構成之流路。因此，能夠防止雜質混入到包含放射性同位素的液體中。如此，依據有關本實施形態之放射性同位素成分分離裝置1，能夠從含有放射性同位素的液體中適當地分離含有放射性同位素的成分，且能夠抑制雜質混入到分離後的成分中。 　　接著，針對上述實施形態的變形例進行說明。如上所述，能夠將固相萃取管柱11設為：將吸附相異成分的管柱串列連接成複數段而構成之所謂複數段結構。在設為這種結構之情況下，能夠適當地使用用於將被各管柱吸附之成分個別回收的方法。 　　具體而言，準備複數個用於將被各管柱吸附之含有RI化合物之成分個別回收的儲存部(相當於第2儲存部13的容器)。而且，在感測器18所測定之感測器值成為閾值以上之情況(S04-YES)下，流路切換部19進行如下控制：將來自固相萃取管柱11的流路的連接對象變更為複數個儲存部當中之既定的儲存部(相當於S05)。然後，在感測器值成為小於閾值之情況(S06-YES)下，進行再次變更流路的控制(相當於S07)。如此，根據由感測器18測定之感測器值，反覆進行流路切換部19所致的流路的變更，從而能夠將被各管柱吸附之相異的RI化合物個別回收。在設為這種結構之情況下可構成為，在流路切換部19，根據感測器值超出閾值之時點(自萃取液開始流動所經過之時間)等事先確定作為流路的變更對象的第2儲存部(回收RI化合物的容器)，而將特定的RI化合物回收至所希望的儲存部。 　　此外，將固相萃取管柱11設為複數段結構之情況下，必須以能夠使被各管柱吸附之成分的脫離時點相異的方式選擇萃取液。又，亦可以設成如下結構：藉由使由相異成分組成的複數種的萃取液流過，使被各管柱吸附之RI化合物在相異的時點脫離。 　　如上述，能夠構成為：固相萃取管柱11由能夠吸附相異成分的複數個管柱構成，根據測定部的測定結果，在流路切換部19從第2儲存部13所包含之複數個容器中選擇儲存從固相萃取管柱排出之液體的容器。藉由設為這種結構，能夠將複數種的RI化合物個別回收。 　　以上，針對本發明的實施形態進行了說明，但本發明並不限定於上述實施形態。 　　例如，在上述實施形態，針對藉由用後即棄式配管等形成之溶液供給流路、固相萃取管柱11、第1排出流路、第2排出流路進行了個別說明，但該等的用後即棄式部分亦可以設為，例如作為安裝於放射性藥劑裝置等中的匣(cassette)內所收容的用後即棄式匣而成為一體化。 　　又，能夠適當地變更放射性同位素成分分離裝置1中所包含之管路L1～L8、閥V1～V4等的結構。又，如上述實施形態所示，處理液儲存部為複數個之情況下，連接處理液儲存部和固相萃取管柱11的所有流路被設為用後即棄式。亦即，對於萃取液所流過之流路以外的處理液的流路，該處理液有可能向第2儲存部(回收放射性同位素成分的容器)導入之情況下，較佳為將該流路設為用後即棄式。Hereinafter, this embodiment will be described in detail with reference to the drawings. In addition, in the description of the drawings, the same elements are denoted by the same reference numerals, and repeated descriptions are omitted. Fig. 1 is a schematic configuration diagram of a radioisotope component separation device according to an embodiment of the present invention. The radioisotope component separation device 1 shown in FIG. 1 is a device for separating a radioisotope-labeled compound (RI compound) from a reaction liquid containing RI obtained by chemically reacting a radioactive element isotope (RI) with a predetermined raw material reagent. Compound. In this embodiment, a radioisotope-labeled compound is referred to as a "radioisotope component". The reaction solution is a solution produced in a RI compound synthesis apparatus. In addition, RI compounds are used in the manufacture of radiopharmaceuticals (including radiopharmaceuticals) used in, for example, PET inspection (positron emission tomography inspection) in hospitals and the like. As shown in FIG. 1, the radioisotope component separation device 1 includes: a solid-phase extraction tube string 11 capable of capturing RI; a first storage portion 12 and a second storage portion 13 storing liquid discharged from the solid-phase extraction tube string 11; The reaction liquid storage section 14 supplies the reaction liquid to the solid phase extraction tube column 11; the processing liquid storage section 15 and the processing liquid storage section 16 supply a plurality of processing liquids to the solid phase extraction tube column 11; the liquid feeding syringe 17;器 18; and flow path switching unit 19. Solid-phase extraction column 11 is a column having a function of using solid phase extraction (Solid Phase Extraction: SPE) to separate RI compounds. Specifically, the solid-phase extraction column 11 is a column filled with particles (resin particles, etc.) capable of adsorbing RI compounds. The particles are not particularly limited as long as they can specifically adsorb the target RI compound. The particles packed in the solid-phase extraction column 11 may be selected according to the characteristics of the reaction solution and the like. In the present embodiment, the case where the solid-phase extraction column 11 has a single-stage structure and only a predetermined RI compound is separated and recovered is described. However, the solid-phase extraction column 11 may be configured to be capable of adsorbing different components. A plurality of segment structures composed of a plurality of pipe columns. In addition, the solid-phase extraction column 11 is a single-use disposable column that is expected to be limited to a single use. The processing liquid refers to a liquid introduced into the solid phase extraction column 11 before the reaction liquid is introduced into the solid phase extraction column 11, or refers to a liquid introduced into the solid phase extraction column 11 after the reaction liquid is introduced into the solid phase extraction tube 11 Imported liquid. Examples of the treatment liquid include an extraction liquid obtained by removing (separating) the RI compound from the resin in the solid phase extraction column 11 and discharging the RI compound downstream of the solid phase extraction column 11. In addition, a cleaning liquid or the like for cleaning the resin in the solid-phase extraction column 11 is also included in the processing liquid. In the present embodiment, a description will be given of a case where the processing liquid storage unit includes both the processing liquid storage unit 15 and the processing liquid storage unit 16, a cleaning liquid is stored in the processing liquid storage unit 15, and a processing liquid storage unit is stored in the processing liquid storage unit 15. The extract is stored in 16. That is, the processing liquid storage section 16 functions as an extraction liquid storage section. However, the amount is appropriately changed depending on the type of the processing liquid required in the separation and recovery step of the RI compound. The first storage section 12 and the second storage section 13 have a function of storing the liquid discharged from the solid-phase extraction tube string 11. In this embodiment, a case will be described in which the first storage section 12 functions as a so-called waste liquid container, and the second storage section 13 functions as a recovery container for recovering RI compounds. In the radioisotope component separation device 1 according to this embodiment, the recovery target is a component containing an RI compound. Therefore, when the liquid containing the RI compound is discharged from the solid-phase extraction column 11, the liquid is recovered in the second storage section 13. On the other hand, a liquid containing no RI compound is recovered in the first storage section 12. In addition, although the present embodiment shows a case where there are two storage sections, when a plurality of components are recovered, the second storage section 13 for recovery can be set to a plurality (a plurality of containers).管路 On the upstream side of the solid-phase extraction tube string 11, a pipeline L1, a valve V1, and a pipeline L2 are sequentially connected between the reaction liquid storage portion 14 and the solid-phase extraction string 11. The pipeline L1, the valve V1, and the pipeline L2 function as a solution supply flow path in this embodiment. The solution supply flow path is a disposable flow path after use. In addition, the flow path such as the pipe L1 is constituted by, for example, a silicon tube. In addition, the pipelines L3 and L4 from the processing liquid storage unit 15 and the processing liquid storage unit 16 meet at the valve V2, and the combined pipeline L5 is connected to the valve V1. The line L5 is provided with a liquid-feeding syringe 17 through the transmission valve V3. The liquid-feeding syringe 17 has a function of controlling the flow rate of the liquid flowing through the processing liquid-side pipe L5, but a peristaltic pump or the like may be used instead of the liquid-feeding syringe 17. The pipeline L3, the pipeline L4, the valve V2, the pipeline L5, and the valve V3 function as a processing liquid supply flow path of this embodiment. In the present embodiment, the extraction liquid is stored in the processing liquid storage portion 16. Therefore, the pipeline L4, the valve V2, the pipeline L5, and the valve V3 from the processing liquid storage portion 16 to the solid-phase extraction column 11 exhibit the advantages of this embodiment. Function of extraction liquid supply flow path. The treatment liquid supply flow path including the extraction liquid supply flow path is a disposable flow path after use. On the upstream side of the solid-phase extraction string 11, the liquid to be supplied to the solid-phase extraction string 11 is selected by switching the valves V1 and V2. The flow rate of the processing liquid supplied from the processing liquid storage unit 15 and the processing liquid storage unit 16 to the solid-phase extraction column 11 is controlled by the control valve V3. A pipeline L6, a valve V4, and a pipeline L7 are sequentially connected between the solid-phase extraction string 11 and the first storage section 12 on the downstream side of the solid-phase extraction string 11. The line L6, the valve V4, and the line L7 function as a first discharge flow path in this embodiment. The first discharge flow path is a disposable flow path after use. In addition, a pipe L8 is connected to the valve V4, and a second storage portion 13 is provided on the downstream side of the pipe L8. The pipeline L6, the valve V4, and the pipeline L8 function as a second discharge flow path in this embodiment. The second discharge flow path is a disposable flow path after use. In addition, the line L6 and the valve V4 have functions as a first discharge flow path and a second discharge flow path. In the radioisotope component separation device 1, the valve V4 is controlled by the flow path switching unit 19. The flow path switching unit 19 detects the radiation of the liquid discharged from the solid-phase extraction string 11 through the line L6 by the sensor 18, and changes the flow path due to the control of the valve V4 based on the result. . The sensor 18 functions as a radiation measurement unit that measures the radiation intensity of the liquid flowing through the flow path. As the sensor 18, for example, a radiation detector can be used. Specifically, when the intensity of the radiation detected by the sensor 18 is greater than or equal to a predetermined threshold, the valve V4 is controlled so that the liquid discharged from the solid-phase extraction column 11 is stored in the second storage via the second discharge flow path. Department 13. On the other hand, when the intensity of the radiation detected by the sensor 18 is smaller than a predetermined threshold, the valve V4 is controlled so that the liquid discharged from the solid-phase extraction column 11 is stored in the first storage via the first discharge flow path. Department 12. By performing the above-mentioned control by the flow path switching unit 19, the radiation intensity becomes equal to or larger than a predetermined threshold, that is, the liquid containing the RI compound can be selectively recovered in the second storage unit 13. (2) Next, a radioisotope separation method using the radioisotope component separation apparatus 1 according to this embodiment will be described with reference to FIG. 2. First, the reaction liquid obtained in the RI compound synthesizing device and the like is supplied to the solid-phase extraction column 11 through a line L1 and a line L2 as a solution supply flow path, and the resin of the solid-phase extraction column 11 captures the RI compound (S01). Next, the liquid-feeding syringe 17 is operated to supply the cleaning liquid stored in the processing liquid storage unit 15 to the solid-phase extraction tube column 11 through the lines L3, L5, and L2. Then, the resin of the solid-phase extraction column 11 is washed with a washing liquid (S02). Next, the liquid-feeding syringe 17 is operated, and the extraction liquid stored in the processing liquid storage unit 16 is supplied (introduced) to the solid-phase extraction tube column 11 through the lines L4, L5, and L2. At the same time as the extraction liquid is introduced, the radiation intensity of the liquid discharged from the solid-phase extraction column is measured by the sensor 18 functioning as a measurement unit (S03). At the same time, the measurement result of the sensor 18 is acquired in the flow path switching unit 19, and the control regarding the flow path switching is started. In the flow path switching unit 19, it is determined whether or not the measured value (sensor value) of the sensor 18 is greater than or equal to a threshold value (S04). When the measurement value is less than the threshold value (S04-NO), the flow path is not changed, and the measurement by the sensor 18 is continued. On the other hand, when the measured value is equal to or greater than the threshold (S04-YES), the flow path switching unit 19 switches the flow path to the second discharge flow path. That is, the connection target of the flow path from the solid-phase extraction column 11 is changed to the second storage unit 13 (S05).变更 After changing the connection target of the flow path from the solid-phase extraction column 11 to the second storage section 13, the measurement by the sensor 18 and the flow path control using the flow path switching section 19 are continued. That is, the flow path switching unit 19 determines whether or not the measurement value (sensor value) of the sensor 18 is smaller than a threshold value (S06). When the measurement value is greater than or equal to the threshold value (S06-NO), the flow path is not changed, and the measurement by the sensor 18 is continued. On the other hand, when the measured value is smaller than the threshold value (S06-YES), the flow path switching unit 19 switches the flow path to the first discharge flow path. That is, the connection target of the flow path from the solid-phase extraction column 11 is changed to the first storage unit 12 (S07). Thereby, only the liquid whose sensor value is more than a threshold value is collect | recovered to the 2nd storage part 13. As described above, in the radioisotope component separation device according to the present embodiment, the radioisotope-containing component can be appropriately recovered in the second storage unit 13. In addition, the pipes and valves that may flow to the second storage unit 13 that collects components containing radioactive isotopes are disposed of after use, which can suppress the mixing of impurities and the like. In the manufacturing steps of conventional radiopharmaceuticals, a method using a solid-phase extraction column and a method using HPLC have been discussed as methods for recovering radioisotopes synthesized in a synthesis device or the like. However, no matter which method is used, there is still room for improvement in the separation and recovery of RI compounds in the manufacturing steps of radiopharmaceuticals. First, in a method using a general solid phase extraction column, an RI compound is removed from the resin and recovered by using an extraction solution for the RI compound of the resin adsorbed in the column. However, in the conventional method using a solid-phase extraction column, the operation of separating and recovering a liquid containing a specific component was not performed. Therefore, it is not performed to separate and recover only a liquid containing a specific component. On the other hand, compared with solid-phase extraction columns, the use of HPLC to separate and recover liquids containing specific components is known to improve separation performance. However, HPLC has a feature that liquid is introduced into the column for component separation at high pressure, and the device structure is also complicated. In addition, it is also assumed that the column for component separation is used plural times. Therefore, there is a problem that it is difficult to set the flow path of the radioisotope used in the radiopharmaceutical to a disposable type, and it is difficult to ensure the cleanness of the RI compound to be separated and recovered. On the other hand, according to the radioisotope component separation device 1 according to this embodiment, a sensor 18 is used to monitor the radiation amount of the liquid discharged from the solid-phase extraction column 11. The flow path is switched by the flow path switching section 19 so that the object to be recovered is the second storage section 13. With such a configuration, even when the solid-phase extraction column 11 is used, it is possible to separate and recover only a liquid containing a specific component having a high radiation amount. In addition, in the radioisotope component separation device 1, the flow path of the radioisotope used in the radiopharmaceutical, that is, the reaction liquid supply flow path, the processing liquid supply flow path (including the extraction liquid supply flow path), and the first discharge flow path And the second discharge flow path is a flow path made of a disposable material. Therefore, it is possible to prevent impurities from being mixed into a liquid containing a radioisotope. As described above, according to the radioisotope component separation device 1 according to the present embodiment, a radioisotope-containing component can be appropriately separated from a radioisotope-containing liquid, and impurities can be prevented from being mixed into the separated components. Next, a modification of the above embodiment will be described. As described above, the solid-phase extraction tube string 11 can have a so-called plural-segment structure in which a string of columns in which dissimilar components are adsorbed is connected in a plurality of steps. With such a configuration, a method for individually recovering the components adsorbed by each column can be suitably used. Specifically, a plurality of storage units (corresponding to the second storage unit 13) are prepared for individually recovering the RI compound-containing component adsorbed by each column. When the sensor value measured by the sensor 18 is equal to or greater than the threshold value (S04-YES), the flow path switching unit 19 performs control to change the connection target of the flow path from the solid-phase extraction column 11 It is a predetermined storage section (equivalent to S05) among a plurality of storage sections. When the sensor value becomes smaller than the threshold value (S06-YES), control for changing the flow path again is performed (equivalent to S07). In this way, based on the sensor value measured by the sensor 18, the flow path change caused by the flow path switching unit 19 is repeatedly performed, so that the different RI compounds adsorbed by each column can be individually recovered. In the case of such a configuration, the flow path switching unit 19 may be configured in advance to determine the target of the flow path change based on the point in time when the sensor value exceeds the threshold (the time elapsed since the extraction liquid began to flow) and the like. The second storage unit (a container for recovering the RI compound) collects a specific RI compound into a desired storage unit. In addition, when the solid-phase extraction column 11 has a plural-stage structure, it is necessary to select an extraction solution in such a manner that the separation points of the components adsorbed by the respective columns are different. In addition, a configuration may be adopted in which a plurality of types of extraction liquids composed of dissimilar components are caused to flow through, and the RI compounds adsorbed by the respective columns are separated at different points in time. As described above, it can be configured that the solid-phase extraction column 11 is composed of a plurality of columns capable of adsorbing dissimilar components, and based on the measurement result of the measurement section, the flow path switching section 19 includes a plurality of sections included in the second storage section 13. Among the containers, a container for storing the liquid discharged from the solid phase extraction column is selected. With such a structure, a plurality of RI compounds can be individually recovered. In the foregoing, the embodiments of the present invention have been described, but the present invention is not limited to the above-mentioned embodiments. For example, in the above-mentioned embodiment, the solution supply flow path, the solid-phase extraction column 11, the first discharge flow path, and the second discharge flow path formed by the disposable piping or the like have been described individually, but these The disposable part can also be integrated, for example, as a disposable cartridge stored in a cassette installed in a radiopharmaceutical device or the like. In addition, the configurations of the pipes L1 to L8, the valves V1 to V4, and the like included in the radioisotope component separation device 1 can be changed as appropriate. In addition, as shown in the above-mentioned embodiment, when there are a plurality of processing liquid storage sections, all the flow paths connecting the processing liquid storage section and the solid-phase extraction tube column 11 are of a disposable type. That is, it is preferable that the flow path of the processing liquid other than the flow path through which the extraction liquid flows is introduced into the second storage section (a container for recovering the radioisotope component). Set to disposable.

1‧‧‧放射性同位素成分分離裝置1‧‧‧ Radioisotope component separation device

11‧‧‧固相萃取管柱11‧‧‧ solid phase extraction column

12‧‧‧第1儲存部12‧‧‧The first storage department

13‧‧‧第2儲存部13‧‧‧Second storage department

14‧‧‧反應液儲存部14‧‧‧Reaction liquid storage section

15、16‧‧‧處理液儲存部15, 16‧‧‧ treatment liquid storage department

17‧‧‧送液用注射器17‧‧‧ liquid delivery syringe

18‧‧‧感測器18‧‧‧Sensor

19‧‧‧流路切換部19‧‧‧Flow Path Switching Department

圖1係放射性同位素成分分離裝置的概略結構圖。 　　圖2係說明放射性同位素成分分離方法的流程圖。FIG. 1 is a schematic configuration diagram of a radioisotope component separation device. Figure 2 is a flowchart illustrating a method for separating radioisotope components.

Claims (2)

一種放射性同位素成分分離裝置，係溶液中的放射性同位素成分的分離裝置，其具有： 　　固相萃取管柱，能夠吸附前述溶液中的放射性同位素成分； 　　萃取液儲存部，儲存萃取液，該萃取液能夠使被吸附於前述固相萃取管柱之前述放射性同位素成分脫離； 　　用後即棄式萃取液供給流路，向固相萃取管柱供給儲存於前述萃取液儲存部的前述萃取液； 　　第1儲存部，儲存來自前述固相萃取管柱的液體； 　　第2儲存部，儲存來自前述固相萃取管柱的液體； 　　用後即棄式第1排出流路，連接前述固相萃取管柱和前述第1儲存部； 　　用後即棄式第2排出流路，連接前述固相萃取管柱和前述第2儲存部； 　　測定部，在前述固相萃取管柱的下游側，測定從前述固相萃取管柱排出之液體的放射線量；及 　　流路切換部，根據前述測定部的測定結果，將從前述固相萃取管柱排出之液體的流路在前述第1排出流路和前述第2排出流路之間切換。A radioisotope component separation device is a radioisotope component separation device in a solution, which comprises: a tritium solid phase extraction tube column capable of adsorbing the radioisotope component in the solution; and a tritium extract storage unit for storing an extraction solution. Detach the radioactive isotope components adsorbed on the solid-phase extraction tube column; 即 Dispose the extraction liquid supply flow path after use, and supply the solid-phase extraction tube column with the extraction liquid stored in the extraction liquid storage section; First storage The second storage section stores the liquid from the above-mentioned solid phase extraction column; the second storage section stores the liquid from the above-mentioned solid phase extraction tube; 1 Storage section; 即 Disposable second discharge flow path after use, connecting the solid phase extraction tube column and the second storage section; The measurement section measures the solid phase extraction tube downstream from the solid phase extraction tube column. The radiation amount of the liquid discharged from the column; and the flow path switching section, based on the measurement result of the measurement section, Discharged from the flow path of the solid phase extraction column of liquid in the first discharge passage and the second flow path between the discharge switching. 如申請專利範圍第1項所述之放射性同位素成分分離裝置，其中， 　　前述固相萃取管柱由能夠吸附相異成分的複數個管柱構成， 　　前述第2儲存部包含複數個容器， 　　前述流路切換部，係根據前述測定部的測定結果，將從前述固相萃取管柱排出之液體的流路在前述第1排出流路和前述第2排出流路之間切換，並且從前述複數個容器中選擇儲存從前述固相萃取管柱排出之液體的容器。The radioisotope component separation device according to item 1 of the scope of the patent application, wherein: the aforementioned solid phase extraction column is composed of a plurality of columns capable of adsorbing dissimilar components, the aforementioned second storage section includes a plurality of containers, and the aforementioned flow path The switching section switches the flow path of the liquid discharged from the solid-phase extraction column between the first discharge flow path and the second discharge flow path based on the measurement result of the measurement section, and switches from the plurality of containers. Select a container for storing the liquid discharged from the aforementioned solid phase extraction column.