TW201720424A - 肌膚改善方法及促進膠原蛋白產生之方法 - Google Patents
肌膚改善方法及促進膠原蛋白產生之方法 Download PDFInfo
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Abstract
本發明之課題在於提供一種可經口攝取而促進膠原蛋白產生能力,且亦可持續經口攝取之源自天然且安全性較高的經口攝取用肌膚改善劑、經口攝取用膠原蛋白產生促進劑及飲食品。本發明係一種經口攝取用肌膚改善劑,其目的在於改善肌膚之緊致感、光滑度、皺紋及法令紋,其特徵在於含有越橘(Vaccinium vitis-idaea)及餘甘子(Phyllanthus emblica或Emblica officinale)之植物體或其萃取物;一種經口攝取用膠原蛋白產生促進劑,其特徵在於含有越橘及餘甘子之植物體或其萃取物;或一種飲食品,其特徵在於含有上述經口攝取用肌膚改善劑或經口攝取用膠原蛋白產生促進劑。
Description
本發明係關於一種含有越橘(Vaccinium vitis-idaea)及餘甘子(Phyllanthus emblica或Emblica officinale)之植物體或其萃取物的經口攝取用肌膚改善劑、經口攝取用膠原蛋白產生促進劑、及飲食品。
近年來,作為女性美容方面之煩惱,有隨著年齡增長而皮膚之皺紋或鬆弛增加之問題。並且,已知此種皮膚之皺紋或鬆弛係由於皮膚纖維母細胞之膠原蛋白產生能力降低而引起。
因此,為了促進膠原蛋白之產生,不斷開發了調配有各種植物萃取物之皮膚外用劑(專利文獻1),於皮膚外用劑中,有效成分係經皮吸收而應用於纖維母細胞中,因此根據有效成分之不同,有時於皮膚中之吸收性成為問題,未必能獲得充分之效果。
另一方面,於像食品等般經口攝取之情形時,係直接攝入至體內,故而與外用方式之應用相比有效成分容易吸收,可期待充分之效果。
作為可提高膠原蛋白之產生能力之食品,已知有含有餘甘子之萃取物的膠原蛋白產生促進劑(專利文獻2),業界期待藉由於其中添加其他成分,而開發出一種可進一步促進膠原蛋白之產生,提高不僅面部而是全身之肌膚之緊致感或光滑度,使皺紋或法令紋變得不明顯的肌膚改善效果較高之經口攝取用之肌膚改善劑。
再者,越橘(別名苔桃)之萃取物含有熊果苷,其可作用於酪胺酸酶中而抑制黑色素之合成,故而將其調配於食品等中的發揮美白效果之美容食品等已眾所周知(專利文獻3),但此種越橘(別名苔桃)之萃取物迄今為止尚不知曉與膠原蛋白產生能力相關之效果。
[專利文獻1]日本特開2006-160629號公報
[專利文獻2]日本特開2008-156287號公報
[專利文獻3]日本特開2010-111590號公報
本發明之目的在於提供一種經口攝取而促進膠原蛋白產生能力從而改善肌膚之緊致感等的效果優異,且亦可持續經口攝取之源自天然且安全性較高的經口攝取用肌膚改善劑、經口攝取用膠原蛋白產生促進劑及飲食品。
本發明者為了解決上述課題而進行銳意研究,結果發現,當持續地經口攝取杜鵑花科(Ericaceae)越橘屬(Vaccinium)之越橘(Vaccinium vitis-idaea)及大戟科(Euphorbiaceae)餘甘子屬(Emblica)之餘甘子(Phyllanthus emblica或Emblica officinale)之植物體或其萃取物時,可促進膠原蛋白之產生能力,藉此可表現出肌膚之緊致感或光滑度提高,皺紋或法令紋變得不明顯等改善肌膚之顯著效果,從而完成本發明。
即,本發明係一種經口攝取用肌膚改善劑,其目的在於改善肌膚之緊致感、光滑度、皺紋及法令紋,其特徵在於:含有越橘及餘甘子之植物體或其萃取物。
又,本發明係一種經口攝取用膠原蛋白產生促進劑,其特徵
在於:含有越橘及餘甘子之植物體或其萃取物。
又,本發明係一種飲食品,其特徵在於:含有上述之經口攝取用肌膚改善劑或經口攝取用膠原蛋白產生促進劑。
根據本發明之經口攝取用肌膚改善劑等,當持續地經口攝取時,膠原蛋白量增加、皮膚之彈性提高,藉此遍及全身之肌膚之緊致感或光滑度提高,皺紋或法令紋變得不明顯等,可改善由年齡增大所引起之肌膚老化。
又,本發明之經口攝取用肌膚改善劑等係含有可食用之天然植物之植物體或其萃取物作為有效成分,因此安全性較高,可實現持續之攝取,且可根據各種愛好而設定攝取時之形態,可用作飲食品或經口用醫藥品。
p‧‧‧顯著性概率
R0‧‧‧拉伸容易度
R1‧‧‧恢復至原位置之容易度
R3‧‧‧拉伸容易度
R8‧‧‧容易拉伸且容易恢復之效果之評價
F3‧‧‧包絡最大值與最小值之曲線之間的面積
圖1係表示使用人皮膚真皮纖維母細胞的膠原蛋白產生能力試驗之結果的圖。
圖2係用以根據利用Cutometer所得之測定資料而導出黏彈性評價之指標的概念圖。
圖3係表示由黏彈性測定試驗所得之指標R0之數值的圖。
圖4係表示由黏彈性測定試驗所得之指標R3之數值的圖。
圖5係表示由黏彈性測定試驗所得之指標R8之數值的圖。
圖6係表示由黏彈性測定試驗所得之指標F3之數值的圖。
圖7係表示眼角之皺紋之改善效果的圖。
圖8係表示法令紋之改善效果的圖。
圖9係表示額頭之皺紋之改善效果的圖。
圖10係表示肌膚之滑潤感之改善效果的圖。
圖11係表示面部以外之部位(手、臂)的肌膚之改善效果的圖。
本發明之經口攝取用肌膚改善劑等含有由可經口攝取之杜鵑花科越橘屬(Vaccinium)之越橘(Vaccinium vitis-idaea)及大戟科餘甘子屬(Emblica)之餘甘子(Phyllanthus emblica或Emblica officinale)獲得之植物體或其萃取物作為有效成分。
越橘(Vaccinium vitis-idaea)別稱苔桃,於北歐之北極圈或加拿大大量地自然生長,已知其富含維生素C或檸檬酸。果實可生食,並且常用於果汁、果醬等加工食品中。
作為本發明所使用之越橘之部位,並無特別限定,可任意使用果實(未成熟果實、成熟果實、乾燥果實)、葉、塊根、花、種子等。其中,較佳為使用果實。
本發明所使用之越橘可直接使用新鮮之越橘,亦可使用經乾燥者,但就使用性、製劑化等之方面而言,較佳為以乾燥粉末或溶劑萃取物使用。
作為獲得乾燥粉末之方法,有將植物之各種部位(果實、葉、塊根、花、種子等)或全株細切或粉碎,其後進行乾燥之方法,或者將植物乾燥後細切或粉碎而獲得乾燥粉末之方法。又,亦可適宜採用將植物細切或粉碎,實施醱酵或酵素處理之後,進行乾燥,進而視需要加以粉碎以
成為特定粒徑之方法等。
越橘之萃取物可根據通常之方法而獲得,例如,可藉由將越橘視需要乾燥之後,於萃取溶劑中浸漬固定時間,或者與加熱回流之萃取溶劑接觸,繼而過濾、濃縮而獲得。作為萃取溶劑,只要為通常萃取所使用之溶劑,則可任意使用,可分別單獨地或組合使用例如:水、甲醇、乙醇、丙二醇、1,3-丁二醇、甘油等醇類;氯仿、二氯乙烷、四氯化碳、丙酮、乙酸乙酯等有機溶劑。可將利用上述溶劑萃取所得之萃取液直接使用,或使用經濃縮之萃取物,或者使用將該等萃取物利用吸附法,例如使用離子交換樹脂去除雜質所得者,或利用多孔性聚合物(例如Amberlite XAD-2)之管柱進行吸附後,利用甲醇或乙醇溶出且進行濃縮而成者。又,亦可使用利用分配法,例如以水/乙酸乙酯萃取所得之萃取物等。越橘萃取物作為例如「LINGONBERRY EXTRACT」(ORYZA OIL & FAT CHEMICAL股份有限公司製造)等有市售,亦可使用該等市售品。
本發明所使用之餘甘子(Phyllanthus emblica或Emblica officinale)係屬於大戟科餘甘子屬(Emblica)之落葉亞喬木,分佈於自印度至馬來西亞地區及中國南部,一般認為印度為原產地。餘甘子根據各地域或語言之不同而分別具有固有之名稱,例如亦可稱為:餘柑子、油柑、庵摩勒(Amalaka)、馬六甲樹(Pokok Melaka)、印度醋栗(Indian gooseberry)等。
作為餘甘子之使用部位,並無特別限定,可任意地使用果實(未成熟果實、成熟果實、乾燥果實)、葉、塊根、花、種子等,其中較佳為使用果實。
餘甘子可直接使用新鮮之餘甘子,亦可使用經乾燥者,但就使用性、製劑化等之方面而言,較佳為以乾燥粉末或溶劑萃取物使用。用以獲得乾燥粉末或萃取物之方法並無特別限定,可採用上述越橘中所記載之方法。餘甘子萃取物例如由太陽化學股份有限公司以「SunAmla」等而市售,亦可使用該等市售品。
本發明之經口攝取用肌膚改善劑等如實施例中所詳細敍述般,藉由促進纖維母細胞中之膠原蛋白產生能力而提高肌膚之彈性,結果發揮肌膚之緊致感或光滑度提高,皺紋或法令紋變得不明顯等抑制由年齡增大所引起之肌膚老化的效果。
本發明之經口攝取用肌膚改善劑及經口攝取用膠原蛋白產生促進劑可調配於各種飲食品中,以肌膚改善用之食品之形態而攝取,另外亦可以醫藥製劑之形態而投予。
又,本發明之飲食品可藉由於各種飲食品中調配越橘及餘甘子之植物體或其萃取物而獲得,但於量產步驟中,亦可將上述經口攝取用肌膚改善劑或經口攝取用膠原蛋白產生促進劑製成半成品,將該半成品調配於各種飲食品中,藉此高效率地獲得具有肌膚改善效果之飲食品。
所攝取(投予)之越橘及餘甘子之量可根據攝取(投予)之方法或劑型等適當決定,較理想的是以將每一日之攝取(投予)量設為如下之方式進行製備:以乾燥質量換算越橘為0.1mg~10g,較佳為1~1000mg,尤佳為10~100mg,餘甘子為0.1mg~10g,較佳為1~1000mg,尤佳為10~100mg。
於將本發明之經口攝取用肌膚改善劑或經口攝取用膠原蛋
白產生促進劑調配於飲食品中之情形時,可視需要任意地選擇併用添加劑。作為添加劑,可包含功能性材料、賦形劑、呈味劑。
作為功能性材料,可列舉:泛酸、葉酸、生物素等各種維生素類;鋅、鈣、鎂、鐵等各種礦物質類;胺基酸、寡糖、蜂膠、蜂王漿、銀杏葉、薑黃、EPA(Eicosapentaenoic acid,二十碳五烯酸)、DHA(Docosahexaenoic acid,二十二碳六烯酸)、輔酶Q10、軟骨素、乳酸菌、乳鐵蛋白、異黃酮、西梅、甲殼素、聚葡萄胺糖、葡萄糖胺、α-硫辛酸、巴西蘑菇(Agaricus)、藤黃果、蜂膠、膠原蛋白、蝦紅素、福斯高林(ForsLean)、兒茶素、芝麻素、神經醯胺、埃及野麻嬰(Corchorus olitorius)、螺旋藻(Spirulina)、貓爪草(Cat's Claw)等。該等功能性材料可單獨使用,或亦可組合兩種以上使用。
作為賦形劑,只要為於製成所需之劑型時通常使用者即可,例如可列舉:小麥澱粉、米澱粉、玉米澱粉、馬鈴薯澱粉、糊精、環糊精等澱粉類;結晶纖維素類;乳糖、葡萄糖、砂糖、還原麥芽糖、飴糖、果寡糖、乳化寡糖等糖類;山梨糖醇、赤藻糖醇、木糖醇、乳糖醇、甘露醇等糖醇類。該等賦形劑可單獨使用,或可組合兩種以上使用。
作為呈味劑,可列舉:文旦萃取物、荔枝萃取物、柚子萃取物等各種果汁萃取物;蘋果汁、橘子汁、檸檬汁等各種果汁;桃子香料、梅子香料、酸乳酪香料等各種香料;乙醯磺胺酸鉀、蔗糖素、赤藻糖醇、寡糖類、甘露糖、木糖醇、異構化糖類等各種甜味劑;檸檬酸、蘋果酸、酒石酸、葡萄糖酸等各種酸味劑;綠茶、烏龍茶、巴拿巴茶(Banaba tea)、杜仲茶、鐵觀音茶、薏苡茶、七葉膽茶、茭白茶、昆布茶等各種茶成分等。
該等呈味劑可單獨使用,亦可組合兩種以上使用。
此外之著色劑、防腐劑、增黏劑、結合劑、崩解劑、分散劑、穩定劑、膠化劑、抗氧化劑、界面活性劑、防腐劑、pH值調整劑等可適當選擇食品等中所使用之公知者而使用。
作為飲食品之形態,可任意選擇例如液體狀、固體狀、顆粒狀、粒狀、糊狀、凝膠狀等。
作為飲食品之具體例,例如可列舉:果汁飲料、蔬菜汁、清涼飲料、茶等飲料類;湯、布丁、酸乳酪、蛋糕預混料製品、糕點類、餅乾、糖果、軟糖、口香糖等各種普通加工食品;另外,飲料劑等營養輔助飲食品、指定保健用飲食品、功能性飲食品、健康飲食品等。但是,並不限定於該等示例。
將本發明之經口攝取用肌膚改善劑或經口攝取用膠原蛋白產生促進劑以醫藥製劑之形態而使用時,可適當地選擇劑型,例如可製成錠劑、顆粒劑、散劑、膠囊劑等固體製劑,或內服液劑、糖漿劑等經液體製劑等,於該等醫藥製劑中,亦可適當地使用通常所用之結合劑、崩解劑、增黏劑、分散劑、再吸收促進劑、矯味劑、緩衝劑、界面活性劑、溶解助劑、防腐劑、乳化劑、等張劑、穩定劑或pH值調整劑等賦形劑。
[實施例]
以下,對為了確認本發明之效果而進行之試驗及結果更詳細地進行說明,但本發明並不限定於以下之試驗例或實施例。
試驗1 「膠原蛋白產生能力之測定」
(試驗方法)
1.將人真皮纖維母細胞播種至24孔板中,利用含有10%FBS之DMEM培養液連續進行培養。
2.確認形成為融合狀態之後,更換成包含各樣品之0.5mL之DMEM培養液,於37℃下培養72小時。
3.培養後,使用ELISA法(Enzyme-linked immunosorbent assay,酵素結合免疫吸附分析法)測定培養液中之膠原蛋白濃度。
(處理液)
樣品1:對照品
樣品2:餘甘子10μg/mL
樣品3:越橘10μg/mL
樣品4:越橘5μg/mL+餘甘子5μg/mL
餘甘子係使用太陽化學股份有限公司製造之「SunAmla」(商品名)。又,具有相同效果之萃取物(餘甘子萃取物)可使用熱水或水等極性溶劑,自作為使用部位之果實萃取獲得。
越橘係使用ORYZA OIL & FAT CHEMICAL股份有限公司製造之「LINGONBERRY EXTRACT」(商品名)。又,具有相同效果之萃取物(越橘萃取物)可使用熱水或乙醇等極性溶劑,自作為使用部位之果實萃取獲得。
為了基於所收集之樣品驗證組間是否存在差異,進行統計處理。若檢驗結果顯示之顯著性概率(p)為5%(p<0.05),則認為檢驗中所使用之資料項目(稱為變數)間存在顯著差(significant difference)。若p未達10%(p<0.1),則認為檢驗時所使用之資料項目(稱為變數)間存在顯
著之傾向差。產生顯著差及顯著之傾向差表示因某種原因而產生差異。進行生物學試驗時,最終是否存在顯著差成為導出組間是否存在變化的方法。統計分析係利用Tukey法而實施。
圖1係表示上述樣品1~4之膠原蛋白產生能力之測定結果的圖。根據圖1之結果,確認到樣品4(調配有越橘及餘甘子)相對於樣品1(對照品)於膠原蛋白產生能力方面存在顯著差(p<0.001)。又,確認到樣品4(調配有越橘及餘甘子)與樣品2(單獨調配有餘甘子)相比於膠原蛋白產生能力方面存在傾向差(p<0.10)。據此,確認本發明之肌膚改善劑等藉由越橘與餘甘子之相乘效果,而增加膠原蛋白產生之效果優異。
繼而,由官能檢查員進行持續試驗,藉由以下所示之試驗確認本發明之效果。準備4種樣品,對於各樣品由15名官能檢查員進行持續服用試驗。官能檢查員藉由經口攝取1日1支地服用試驗試樣(飲料)8週。
將試驗試樣(飲料)之配方示於表1。
試驗2 「皮膚之黏彈性之測定」
(試驗方法)
於持續服用試驗後(服用8週後),使用Cutometer(Courage+Khazaka公司製造)測定官能檢查員之背部皮膚之皮膚黏彈性。
Cutometer係評價於固定壓力下吸引後之肌膚之變化的機器,可獲得如圖2所示之圖資料。圖中所示之R0~R8及F3之數值分別表示以下之物性。
R0:拉伸容易度(以充分拉伸為佳數值越大越佳)
R1:恢復至原位置之容易度(以恢復至原位置為佳數字較小為佳)
R3:拉伸容易度(以充分拉伸為佳數字越大越佳)
R8(R0-R1):容易拉伸且容易恢復之效果之評價數值越大越佳
F3:上述包絡最大值(Envelope max)與最小值(min)之曲線(curve)之間的面積(相當於R8之累積)數值越大越佳
圖3~6係表示皮膚之黏彈性測定之結果的圖。D組(越橘+餘甘子)之皮膚之黏彈性效果優異,相對於A組(安慰劑)於黏彈性R0、R3、R8及F3上確認到顯著差。又,D組(越橘+餘甘子)相對於C組(越橘)於R8上確認到顯著差(p<0.05),於R0、R3及F3上確認到傾向差(p<0.10)。由此,確認本發明之肌膚改善劑等的提高皮膚之彈性,改善肌膚之緊致感等的效果優異。
試驗3 「眼角之皺紋評價」
(試驗方法)
於持續服用試驗開始日及持續服用試驗開始8週後(試驗結束日),拍
攝眼角之照片。由皮膚科專科醫生,使用皺紋等級標準照片對各時間點之照片實施照片判定,以1/4值之得分進行評分。
由服用前後之得分,藉由「皺紋改善度」=「試樣服用後之得分」-「試樣服用前之得分」之式而算出皺紋改善度。再者,關於組間差,實施曼-惠特尼(Mann-Whitney)之U檢驗。
<皺紋之視覺判定基準>
使用皺紋等級標準照片(皺紋等級為0~7之8個等級)(日本香妝品學會,化妝品功能評價法準則)實施視覺評價,以1/4值之得分(例如3.25、3.5等)進行評分。皺紋判定係由皮膚科專科醫生實施。
「得分:判定基準」
等級0:無皺紋
等級1:確認到些微不明顯之較淺之皺紋
等級2:確認到些微明顯之較淺之皺紋
等級3:確認到明顯之較淺之皺紋
等級4:於明顯之較淺之皺紋中,確認到些微稍深之皺紋
等級5:確認到稍深之皺紋
等級6:確認到明顯且較深之皺紋
等級7:確認到非常深之皺紋
圖7係表示皺紋改善度之結果的圖。確認到D組(越橘+餘甘子)之肌膚之皺紋改善效果優異,相對於A組(安慰劑)存在顯著差(p<0.01)。又,確認到D組(越橘+餘甘子)相對於C組(越橘)亦存在傾向差(p<0.10)。由此,確認本發明之肌膚改善劑等的改善肌膚之皺紋
之效果優異。
試驗4 「問卷調查評價」
(試驗方法)
於持續服用試驗開始日及試驗開始後1日後、3日後、7日後、14日後、28日後、56日後,針對「法令紋之明顯程度」、「額頭皺紋之明顯程度」、「肌膚之滑潤感」等實施問卷調查。
問卷調查係藉由作為評價尺度而通用之VAS(視覺類比尺度(visual analogue scale)之簡稱)進行評價。亦即,於各調查日,發給試驗者記載有劃為10cm之一橫向直線的直線之用紙,將直線之左端設為「無實際感覺」,將右端設為「有實際感覺」,請試驗者將可實際感覺之程度記為直線上之位置(=試驗者於線段上之一部位附上標記),將以試驗開始之位置為基準向右側(或左側)移動之距離作為尺度值進行評價。再者,用以驗證組間差之統計分析係藉由Tukey法而實施。
圖8係關於「法令紋」、圖9係關於「額頭之皺紋」、圖10係關於「肌膚之滑潤感」表示藉由問卷調查所得之改善度之結果的圖。圖中之*(p<0.05)、+(p<0.10)為相對於A組(安慰劑)可確認到顯著差或傾向差之部分。又,表2中係將於各調查日比較得出之組間之顯著差(p<0.05)、傾向差(p<0.10)分別以○、△表示。根據該等之結果,D組(越
橘(RB)+餘甘子)的法令紋之改善、額頭之皺紋之改善、及肌膚之滑潤感之改善優異,且如圖8~10所示,於服用7日後,所有項目均可確認到相對於A組(安慰劑)具有顯著差之效果。又,如表2所示,D組(越橘(RB)+餘甘子)相對於C組(越橘(RB))亦於法令紋、額頭之皺紋、及肌膚之滑潤感(光滑度)之改善效果方面確認到顯著差(p<0.05)或傾向差(p<0.10)。
圖11係表示服用56日後進行的關於手、臂之問卷調查的結果。於評價皮膚之老化的所有項目中,D組(越橘+餘甘子)均顯示出優異之改善效果,尤其是於「肌膚之水潤度」、「肌膚之光滑度」、「肌膚之光澤」、「枕頭痕跡之附著容易度」、「肌膚瘙癢」、「肌膚之透明感」方面,確認到相對於A組(安慰劑)具有顯著差*(p<0.05)或傾向差+(p<0.10)之改善效果。由此,可確認本發明之肌膚改善劑等對於面部以外之部位亦具有優異之肌膚改善效果。
Claims (2)
- 一種肌膚改善方法,使用經口攝取用肌膚改善劑,該經口攝取用肌膚改善劑含有越橘(Vaccinium vitis-idaea)之植物體或其萃取物及餘甘子(Phyllanthus emblica或Emblica officinale)之植物體或其萃取物。
- 一種促進膠原蛋白產生之方法,使用越橘(Vaccinium vitis-idaea)之植物體或其萃取物及餘甘子(Phyllanthus emblica或Emblica officinale)之植物體或其萃取物。
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