TW201713277A - Method of calculating age index of scalp and hair, method of evaluating anti-aging effect on scalp and hair and method of evaluating degree of aging of scalp and hair - Google Patents
Method of calculating age index of scalp and hair, method of evaluating anti-aging effect on scalp and hair and method of evaluating degree of aging of scalp and hair Download PDFInfo
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以下揭露內容是有關於一種能夠全面地評估頭皮及頭髮的年齡指數的方法，藉由利用關於相對於頭皮及頭髮反映老化概念的每一評估類別的資料庫經由回歸分析計算考慮與老化的相關的指數。The following disclosure relates to a method for comprehensively assessing the age index of the scalp and hair by considering the correlation with aging via regression analysis using a database of each assessment category that reflects the concept of aging relative to the scalp and hair. index.
根據年齡，老化現象出現在頭髮中（類似於皮膚），且隨著老化的推進，出現各種改變及問題。一般而言，藉由頭髮的外表皮層的健康程度來判定頭髮老化的程度，且將具有寬、柔軟且光滑的表皮層的頭髮評估為健康的頭髮。頭髮的老化已知主要具有以下四個原因及現象。第一，頭髮可歸因於由頭髮中皮脂及水分的缺乏引起的彈性減小而變薄，以使得頭髮可容易斷裂且其彈性可降低。第二，表皮層可歸因於頭髮中皮脂及水分的缺乏而脫落以使得可出現靜電，且頭髮末端分叉並變枯糙。第三，頭髮的外表皮層可被損壞及脫落，且其內表皮層可破裂，以使得光的散射反射可增加，且因此整體頭髮的光澤度可降低。第四，根據年齡，可出現諸如灰髮、脫髮以及其類似者的現象。另外，作為如上文所描述的促進頭髮老化的原因，存在染髮、燙髮、使用吹風機過度吹乾、紫外光、營養不均衡、壓力以及其類似者。最近，除使用諸如洗髮精、潤髮素或其類似者的髮用化妝品清潔頭髮且防止靜電外，亦持續地進行對提高頭髮中的營養及光澤度的嘗試。Depending on the age, aging occurs in the hair (similar to the skin), and as the aging progresses, various changes and problems occur. In general, the degree of hair aging is judged by the health of the outer skin layer of the hair, and the hair having a wide, soft and smooth skin layer is evaluated as healthy hair. Hair aging is known to have four main causes and phenomena. First, the hair is thinned by the decrease in elasticity caused by the lack of sebum and moisture in the hair, so that the hair can be easily broken and its elasticity can be lowered. Second, the epidermal layer can be detached due to the lack of sebum and moisture in the hair so that static electricity can occur and the ends of the hair bifurcate and become rough. Third, the outer skin layer of the hair can be damaged and detached, and the inner skin layer can be broken so that the scattering reflection of light can be increased, and thus the gloss of the entire hair can be lowered. Fourth, depending on age, phenomena such as gray hair, hair loss, and the like may occur. In addition, as the reason for promoting hair aging as described above, there are hair dyeing, perming, excessive drying using a hair dryer, ultraviolet light, nutritional imbalance, pressure, and the like. Recently, in addition to using hair cosmetics such as shampoo, conditioner or the like to clean the hair and prevent static electricity, attempts have been made to improve the nutrition and gloss in the hair.
當前，作為量測頭髮老化的方法，僅已使用如下方法：確認使用掃描電子顯微鏡（scanning electron microscope；SEM）或原子力顯微鏡（atomic force microscope；AFM）放大的頭髮的表皮層的評估方法；藉由使用透鏡、攝影機以及監視器量測頭皮及頭髮的組織來直接評估頭皮及頭髮的老化及營養程度的方法（韓國實用新型公開案第0209038號）；或其類似者。然而，在此等評估方法中，由於判定的標準可取決於決定因素而改變，因此不可能客觀地表明頭髮的老化程度，且亦難以提供一致的資料。Currently, as a method of measuring hair aging, only the following method has been used: a method of evaluating the epidermal layer of hair enlarged using a scanning electron microscope (SEM) or an atomic force microscope (AFM) is confirmed; A method of directly measuring the aging and nutrient level of the scalp and hair using a lens, a camera, and a monitor to measure the scalp and hair tissue (Korean Utility Model Publication No. 0209038); or the like. However, in such evaluation methods, since the criteria for the determination may vary depending on the determinant, it is impossible to objectively indicate the degree of aging of the hair, and it is also difficult to provide consistent data.
最近，隨著使用髮用化妝品組合物或化學品或其類似者的消費者對能夠最少化頭髮老化的產品的需求已增加，對於處在製備髮用化妝品組合物或化學品的位置中的彼等產品，需要研發一種能夠在應用產品時準確地量測頭髮中的初始損壞程度及量化抗老化效應作為目標資料以便研發產品從而滿足消費者需求的評估方法。Recently, as consumers who use hair cosmetic compositions or chemicals or the like have increased their demand for products that are capable of minimizing hair aging, for those in a position to prepare a hair cosmetic composition or chemical. Such products need to develop an evaluation method that can accurately measure the initial damage in the hair and quantify the anti-aging effect as a target data in order to develop products to meet consumer needs.
因此，本發明申請人完成本發明以便提供一種能夠藉由利用關於相對於頭皮及頭髮反映老化概念的每一評估類別的資料庫經由回歸分析計算考慮與老化的相關的指數來全面地評估頭皮及頭髮的老化程度的方法。Accordingly, the applicant of the present invention has completed the present invention to provide a comprehensive assessment of the scalp and by utilizing a regression analysis to calculate an index relating to aging by utilizing a database of each evaluation category for reflecting aging concepts relative to the scalp and hair. The method of aging the hair.
本發明的實施例是有關於提供一種藉由顯著評估類別的組合來計算回歸方程式的方法，所述方法能夠基於用於頭皮及頭髮的每一顯著評估類別的資料庫而量化頭皮及頭髮的年齡指數。Embodiments of the present invention are directed to a method of calculating a regression equation by significantly evaluating combinations of categories that are capable of quantifying the age of the scalp and hair based on a database for each significant assessment category of scalp and hair. index.
本發明的另一實施例是有關於提供一種藉由顯著評估類別的組合使用回歸方程式評估頭皮及頭髮的老化程度以及其上的抗老化效應的方法。Another embodiment of the present invention is directed to providing a method for assessing the degree of aging of the scalp and hair and the anti-aging effects thereon using a regression equation by significantly evaluating the combination of categories.
在一個通用態樣中，提供一種計算頭皮及頭髮的年齡指數的方法，其包含：分別針對多個受試者的頭皮及頭髮量測多個評估類別的第一步驟；使用相關分析自評估類別中的每一者提取與老化相關的評估類別的第二步驟；組合所提取評估類別中的兩者或多於兩者，並使用多元回歸分析自組合中的每一者選擇與老化相關的有效評估類別的組合的第三步驟；量測在第三步驟中針對多個受試者選擇的評估類別中的每一者，以收集關於評估類別中的每一者的資料的第四步驟；以及基於所收集資料計算相對於頭皮及頭髮反映老化概念的方程式的第五步驟。In a general aspect, a method of calculating an age index for the scalp and hair comprising: a first step of measuring a plurality of assessment categories for scalp and hair of a plurality of subjects, respectively; using the correlation analysis self-assessment category Each of the two steps of extracting an assessment category associated with aging; combining two or more of the extracted assessment categories, and using multiple regression analysis to select each of the combinations to be effective in relation to aging a third step of evaluating a combination of categories; measuring each of the evaluation categories selected for the plurality of subjects in the third step to collect a fourth step of collecting information about each of the categories of assessments; A fifth step of calculating an equation reflecting the concept of aging relative to the scalp and hair based on the collected data.
根據本發明的例示性實施例的評估類別可為選自以下各者的一或多者：脫髮、灰髮、光澤度、枯糙、皮脂、水分、頭髮密度、頭髮直徑、捲曲、色差、皮屑、紅斑以及其類似者，但不限於此。The evaluation category according to an exemplary embodiment of the present invention may be one or more selected from the group consisting of: hair loss, gray hair, gloss, roughness, sebum, moisture, hair density, hair diameter, curl, color difference, skin Chips, erythema, and the like, but are not limited thereto.
在根據本發明中的例示性實施例的計算頭皮及頭髮的年齡指數的方法中，有效評估類別的組合可為脫髮、灰髮、光澤度以及紅斑的組合。In the method of calculating the age index of the scalp and hair according to an exemplary embodiment of the present invention, the combination of the effective evaluation categories may be a combination of hair loss, gray hair, gloss, and erythema.
在根據本發明的例示性實施例的方程式中，有效評估類別的組合可為自變數，且頭皮及頭髮的年齡指數可為因變數。In the equation according to an exemplary embodiment of the present invention, the combination of the effective evaluation categories may be an independent variable, and the age index of the scalp and hair may be a dependent variable.
根據本發明的例示性實施例的計算頭皮及頭髮的年齡指數的方法可滿足以下方程式1。 [方程式1] (頭皮及頭髮的年齡指數) =(33.0±5.0)+(2.23±0.52)´(脫髮級別)+(3.31±0.64) ´(灰髮級別)+(0.95±0.21)´(光澤度級別)+(0.31±0.17) ´(紅斑級別)The method of calculating the age index of the scalp and the hair according to an exemplary embodiment of the present invention can satisfy the following Equation 1. [Equation 1] (age index of scalp and hair) = (33.0 ± 5.0) + (2.23 ± 0.52) ́ (hair loss level) + (3.31 ± 0.64) ́ (gray hair level) + (0.95 ± 0.21) ́ (gloss Degree level) + (0.31 ± 0.17) ́ (red spot level)
可使用指示顯著性等級與相關係數的p值作為準則來評估根據本發明的例示性實施例的在第二步驟及第三步驟中與老化的相關，其中p值可在0至0.05，較佳在0至0.01，且更佳在0至0.001的範圍內，但不限於此。The p-value indicating the significance level and the correlation coefficient may be used as a criterion to evaluate the correlation with aging in the second step and the third step according to an exemplary embodiment of the present invention, wherein the p value may be from 0 to 0.05, preferably It is in the range of 0 to 0.01, and more preferably in the range of 0 to 0.001, but is not limited thereto.
在另一通用態樣中，提供一種藉由在用髮用化妝品組合物治療頭皮及頭髮之前及之後比較相對於頭皮及頭髮反映老化概念的方程式1的數值來評估頭皮及頭髮上的抗老化效應的方法。In another general aspect, there is provided an anti-aging effect on the scalp and hair by comparing the values of Equation 1 which reflects the concept of aging relative to the scalp and hair before and after treatment of the scalp and hair with the hair cosmetic composition. Methods.
根據本發明的例示性實施例的髮用化妝品組合物可選自以下各者：生髮油、頭髮滋養乳液、護髮素、護髮精華素、頭髮護理劑、潤髮素、洗髮精、洗髮液、洗髮乳、頭髮定型劑、頭髮著色劑、頭髮漂白劑以及其類似者，但不限於此。The hair cosmetic composition according to an exemplary embodiment of the present invention may be selected from the group consisting of hair oil, hair nourishing lotion, hair conditioner, hair care essence, hair care agent, conditioner, shampoo, and wash. Hair liquids, shampoos, hair styling agents, hair colorants, hair bleaches, and the like, but are not limited thereto.
在另一通用態樣中，提供一種使用相對於頭皮及頭髮反映老化概念的方程式1評估頭皮及頭髮的老化程度的方法。In another general aspect, a method of assessing the degree of aging of the scalp and hair using Equation 1 which reflects the concept of aging relative to the scalp and hair is provided.
將詳細描述根據本發明的一種計算頭皮及頭髮的年齡指數的方法以及一種使用所述方法評估頭皮及頭髮的老化程度以及頭皮及頭髮上的抗老化效應的方法。此處，除非另外定義，否則本說明書中所使用的技術術語及科學術語具有熟習本發明所涉及技術者所理解的一般含義，且對不必要地混淆本發明要旨的已知功能及組態的描述將在以下描述中省略。A method of calculating the age index of the scalp and hair according to the present invention and a method for evaluating the degree of aging of the scalp and hair and the anti-aging effect on the scalp and hair using the method will be described in detail. Here, unless otherwise defined, the technical terms and scientific terms used in the specification have the ordinary meaning understood by those skilled in the art to which the invention relates, and the known functions and configurations unnecessarily obscuring the gist of the present invention. The description will be omitted in the following description.
本發明申請人完成本發明以便改良僅基於使用視覺評估對量測參數進行的單一分析而評估頭皮及頭髮的老化程度的方法。本發明可提供一種能夠藉由自累積自各種年齡的受試者的關於頭皮及頭髮的資訊計算考慮與老化的相關的年齡指數來根據目標及顯著數值全面地評估頭皮及頭髮的老化程度的方法。The Applicant has completed the present invention in order to improve the method of assessing the degree of aging of the scalp and hair based solely on the use of a visual assessment of a single analysis of the measured parameters. The present invention can provide a method for comprehensively evaluating the degree of aging of the scalp and hair according to the target and the significant value by calculating the age index related to aging from the information on the scalp and hair accumulated from subjects of various ages. .
另外，由於在先前技術中尚未建立評估頭皮及頭髮的老化程度的系統性及統計性方法，因此預期本發明廣泛地用於評估頭皮及頭髮的老化程度。In addition, since a systematic and statistical method for assessing the degree of aging of the scalp and hair has not been established in the prior art, the present invention is expected to be widely used to evaluate the degree of aging of the scalp and hair.
根據本發明的計算頭皮及頭髮的年齡指數的方法包含：分別針對多個受試者的頭皮及頭髮量測多個評估類別的第一步驟；使用回歸分析自評估類別中的每一者提取與老化相關的評估類別的第二步驟；組合所提取評估類別中的兩者或多於兩者及使用多元回歸分析自組合中的每一者選擇與老化相關的有效評估類別的組合的第三步驟；量測在第三步驟中針對多個受試者選擇的評估類別中的每一者以收集關於評估類別中的每一者的資料的第四步驟；以及基於所收集資料計算相對於頭皮及頭髮反映老化概念的方程式的第五步驟。The method for calculating the age index of the scalp and hair according to the present invention comprises: a first step of measuring a plurality of evaluation categories for the scalp and the hair of the plurality of subjects, respectively; and using the regression analysis to extract each of the self-assessment categories a second step of aging-related assessment categories; a third step of combining two or more of the extracted assessment categories and using a multiple regression analysis for each of the combinations to select a combination of effective assessment categories associated with aging Measuring a fourth step of collecting information about each of the evaluation categories for each of the evaluation categories selected for the plurality of subjects in the third step; and calculating the relative scalp and based on the collected data The hair reflects the fifth step of the equation of the aging concept.
根據本發明的例示性實施例的第一步驟是對處在20歲至60歲的多個受試者執行，且評估類別可選自脫髮、灰髮、光澤度、枯糙、皮脂、水分、頭髮密度、頭髮直徑、捲曲、色差、皮屑、紅斑以及其類似者，但不限於此。另外，可累積用於評估類別中的每一者的量測結果，藉此使得有可能建構資料庫。The first step in accordance with an exemplary embodiment of the present invention is performed on a plurality of subjects between the ages of 20 and 60, and the assessment category may be selected from the group consisting of hair loss, gray hair, gloss, roughness, sebum, moisture, Hair density, hair diameter, curl, chromatic aberration, dander, erythema, and the like, but are not limited thereto. In addition, the measurement results for evaluating each of the categories can be accumulated, thereby making it possible to construct a database.
為在評估類別中的每一者當中提取與老化(年齡)相關的評估類別，任意地選擇多個受試者的結果，且基於評估類別的結果值執行回歸分析。在此狀況下，將評估類別設定為影響老化（年齡）的自變數，且將老化（年齡）設定為受自變數影響的因變數，藉此確認與老化的相關。To extract an evaluation category related to aging (age) among each of the evaluation categories, the results of the plurality of subjects are arbitrarily selected, and regression analysis is performed based on the result values of the evaluation categories. In this case, the evaluation category is set as an independent variable that affects aging (age), and the aging (age) is set as the dependent variable affected by the self-variation, thereby confirming the correlation with aging.
在進行回歸分析時，使用對應於一種統計軟體的IBM SPSS Statistics 20.0（IBM）。在使用IBM SPSS Statistics 20.0（IBM）的狀況下，可獲得p值，其為展現顯著性等級以及自變數與因變數之間的相關的值。使用如上文所描述獲得的p值來提取取決於老化（年齡）而顯著改變的自變數。在此狀況下，以自高影響至低影響的順序提取所提取的自變數，且基於標準化係數β值而評估對老化的影響程度。In the regression analysis, IBM SPSS Statistics 20.0 (IBM) corresponding to one statistical software was used. In the case of IBM SPSS Statistics 20.0 (IBM), a p-value is obtained, which is a value that exhibits a significance level and a correlation between the independent variable and the dependent variable. The p-value obtained as described above was used to extract an independent variable that significantly changed depending on aging (age). In this case, the extracted independent variables are extracted in order from high influence to low influence, and the degree of influence on aging is evaluated based on the normalization coefficient β value.
在根據本發明的例示性實施例的計算頭皮及頭髮的年齡指數的方法中，脫髮、灰髮、光澤度、頭髮密度、紅斑以及其類似者對應於藉由上文所提及的方法提取的評估類別。In the method of calculating the age index of the scalp and the hair according to an exemplary embodiment of the present invention, hair loss, gray hair, gloss, hair density, erythema, and the like correspond to the method extracted by the method mentioned above. Evaluation category.
另外，藉由組合所提取評估類別中的兩者或多於兩者執行多元回歸分析。可藉由使用多元回歸分析來確認取決於評估類別的組合的與老化（年齡）的相關，藉此使得可選擇有效評估類別的組合。在此狀況下，更具體而言，多元回歸分析可為多元線性回歸分析。使用多元線性回歸分析確認兩個或大於兩個自變量之間的線性特性，且藉由所述組合在考慮相互干擾的情況下執行回歸分析。此外，藉由獲得如上文所描述的p值來判定取決於評估類別的組合的與老化（年齡）的相關的顯著性，且使用調整的R2 值選擇具有高R平方的最佳組合。此處，評估類別的選定最佳組合為脫髮、灰髮、光澤度以及紅斑的組合。In addition, multiple regression analysis is performed by combining two or more of the extracted evaluation categories. A correlation with aging (age) depending on the combination of evaluation categories can be confirmed by using multiple regression analysis, thereby enabling selection of a combination of effective evaluation categories. In this case, more specifically, multiple regression analysis can be a multiple linear regression analysis. Multiple linear regression analysis was used to confirm linearity between two or more independent variables, and regression analysis was performed by the combination taking into account mutual interference. Further, by obtaining the value of p as hereinbefore described depends on the determined aging (age) is significantly related to a combination of evaluation categories, R 2 and using the adjusted value selecting the best combination of a high R-squared. Here, the selected optimal combination of assessment categories is a combination of hair loss, gray hair, gloss, and erythema.
在根據本發明的例示性實施例的計算頭皮及頭髮的年齡指數的方法中，可使用指示相關的顯著性等級的p值作為準則來評估評估類別與老化之間的相關，其中p值可在0.00至0.05，較佳在0.00至0.01，且更佳在0.00至0.001的範圍內。當p值在上文所提及的範圍中時，可判定相關為顯著的。In the method of calculating the age index of the scalp and the hair according to an exemplary embodiment of the present invention, a correlation between the evaluation category and the aging may be evaluated using a p value indicating a relevant saliency level as a criterion, wherein the p value may be It is 0.00 to 0.05, preferably 0.00 to 0.01, and more preferably 0.00 to 0.001. When the p value is in the range mentioned above, it can be judged that the correlation is significant.
在根據本發明的例示性實施例的方程式中，可將有效評估類別的組合設定為自變數，且可將頭皮及頭髮的年齡指數設定為因變數，且在將脫髮、灰髮、光澤度以及紅斑的量測值中的每一者轉換成考慮其平均值及標準偏差的正常分佈的狀況下，可在將量測值中的每一者轉換成累積分佈函數值以標準化量測值中的每一者之後在考慮資料及年齡標的標準化數值中的每一者之間的相關的情況下計算方程式。In the equation according to an exemplary embodiment of the present invention, the combination of the effective evaluation categories may be set as an independent variable, and the age index of the scalp and the hair may be set as a variable, and the hair loss, gray hair, gloss, and In the case where each of the measured values of the erythema is converted into a normal distribution considering the mean value and the standard deviation, each of the measured values can be converted into a cumulative distribution function value to normalize the measured value. Each of these is then calculated based on the correlation between each of the normalized values of the data and the age mark.
根據本發明的例示性實施例的計算頭皮及頭髮的年齡指數的方法可滿足以下方程式1。在此狀況下，指示頭皮及頭髮的年齡指數愈高，則老化程度愈高。 [方程式1] (頭皮及頭髮的年齡指數) =(33.0±5.0)+(2.23±0.52)´(脫髮級別)+(3.31±0.64) ´(灰髮級別)+(0.95±0.21)´(光澤度級別)+(0.31±0.17) ´(紅斑級別)The method of calculating the age index of the scalp and the hair according to an exemplary embodiment of the present invention can satisfy the following Equation 1. In this case, the higher the age index indicating the scalp and hair, the higher the degree of aging. [Equation 1] (age index of scalp and hair) = (33.0 ± 5.0) + (2.23 ± 0.52) ́ (hair loss level) + (3.31 ± 0.64) ́ (gray hair level) + (0.95 ± 0.21) ́ (gloss Degree level) + (0.31 ± 0.17) ́ (red spot level)
本發明提供一種評估頭皮及頭髮上的抗老化效應的方法及一種評估頭皮及頭髮的老化程度的方法，所述方法藉由比較在用髮用化妝品組合物治療頭皮及頭髮之前及之後的相對於頭皮及頭髮反映老化概念的方程式1的數值而進行。The present invention provides a method for assessing the anti-aging effect on the scalp and hair and a method for assessing the degree of aging of the scalp and hair by comparing the scalp and hair before and after treatment with the hair cosmetic composition. The scalp and hair reflect the values of Equation 1 of the aging concept.
預期使用根據本發明的方程式1準確地估計及驗證所研發的髮用化妝品組合物對抗老化效應的影響，且預期將方程式1用作吾人公司與市場上競爭對手公司的可用產品的品質憑證的手段。另外，可藉由採用根據本發明的使用方程式1的評估方法以高可靠性執行對頭皮及頭或其類似者髮上的抗老化效應的大規模篩選，以使得可在研發預成品時重要地應用評估方法。It is contemplated that Equation 1 according to the present invention is used to accurately estimate and verify the effect of the developed hair cosmetic composition against aging effects, and that Equation 1 is expected to be used as a means of quality documentation for available products of our company and competitor companies on the market. . In addition, large-scale screening of anti-aging effects on the scalp and the head or the like can be performed with high reliability by employing the evaluation method using Equation 1 according to the present invention, so that it is important to develop the pre-finished product. Apply the assessment method.
在此狀況下，髮用化妝品組合物可選自以下各者：生髮油、頭髮滋養乳液、護髮素、護髮精華素、頭髮護理劑、潤髮素、洗髮精、洗髮液、洗髮乳、頭髮定型劑、頭髮著色劑、頭髮漂白劑以及其類似者，但不限於此。In this case, the hair cosmetic composition may be selected from the group consisting of hair oil, hair nourishing lotion, hair conditioner, hair care serum, hair care agent, conditioner, shampoo, shampoo, and washing. Hair creams, hair styling agents, hair colorants, hair bleaches, and the like, but are not limited thereto.
在下文中，將參考以下實例更詳細描述本發明。然而，僅出於輔助理解本發明而提供以下實例，但本發明的範疇不限於以下實例。Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the following examples are provided only to assist the understanding of the present invention, but the scope of the present invention is not limited to the following examples.
（實例1）(Example 1)
步驟1。step 1.
使用以下方法自作為目標的處在20歲至60歲的1000個受試者得到關於脫髮、灰髮、光澤度、枯糙、皮脂、水分、頭髮密度、頭髮直徑、捲曲、色差、皮屑以及紅斑的資料。The following methods were used to obtain hair loss, gray hair, gloss, roughness, sebum, moisture, hair density, hair diameter, curl, color difference, dandruff, and the like from 1000 subjects aged 20 to 60 years old. Red spot information.
（量測脫髮的方法）(measuring method of hair loss)
根據修改的薩文標度（Savin Scale）標準，將脫髮程度分成5個級別，且將脫髮的量測結果指示為數值。基於中間頭髮部分的寬度，將寬度小於0.1公分的狀況判定為1級，將寬度為0.1公分或大於0.1公分至小於0.5公分的狀況判定為2級，將寬度為0.5公分或大於0.5公分至小於1.0公分的狀況判定為3級，將寬度為1.0公分或大於1.0公分至小於2.0公分的狀況判定為4級，且將寬度為2.0公分或大於2.0公分的狀況判定為5級。According to the modified Savin Scale standard, the degree of hair loss was divided into 5 levels, and the measurement results of hair loss were indicated as numerical values. Based on the width of the intermediate hair portion, a condition in which the width is less than 0.1 cm is judged as level 1, and a condition in which the width is 0.1 cm or more and more than 0.1 cm to less than 0.5 cm is judged to be 2, and the width is 0.5 cm or more and 0.5 cm or less. The condition of 1.0 cm was judged to be level 3, and the case where the width was 1.0 cm or more and more than 1.0 cm to less than 2.0 cm was judged to be level 4, and the case where the width was 2.0 cm or more was judged to be level 5.
（量測灰髮的方法）(method for measuring gray hair)
在攝取對應於距髮根5至8公分的頭髮部分（區域：9平方公分）的相片及將高斯（Gaussinan）模糊應用於相片之後，使用IMAGE pro計算亮度（L）值。在此狀況下，基於黑髮及白髮，將亮度改變速率為0%的狀況判定為1級，將亮度改變速率大於0%至20%或小於20%的狀況判定為2級，將亮度改變速率大於20%至40%或小於40%的狀況判定為3級，將亮度改變速率大於40%至60%或小於60%的狀況判定為4級，且將亮度改變速率大於60%至80%或小於80%的狀況判定為5級。The brightness (L) value was calculated using IMAGE pro after taking a photo corresponding to a hair portion (region: 9 cm 2 ) 5 to 8 cm from the hair root and applying Gaussinan blur to the photo. In this case, based on the black hair and the white hair, the condition in which the brightness change rate is 0% is judged as level 1, and the condition in which the brightness change rate is greater than 0% to 20% or less than 20% is determined as level 2, and the brightness is changed. A condition in which the rate is greater than 20% to 40% or less than 40% is judged to be level 3, and a condition in which the rate of brightness change is greater than 40% to 60% or less than 60% is judged to be level 4, and the rate of change in brightness is greater than 60% to 80%. Or a condition of less than 80% is judged to be level 5.
（量測光澤度的方法）(method of measuring gloss)
確認由安裝在距受試者頭部1公尺高度處的光所反射的光環。基於使用在上文所提及的條件下攝取的頭部的相片（大小：3公分×4公分）（佔據相片的總面積的70至80%）獲得的由光所反射的光環的大小，將大小為15公分或大於15公分至小於20公分的狀況判定為1級，將大小為10公分或大於10公分至小於15公分的狀況判定為2級，將大小為5公分或大於5公分至小於10公分的狀況判定為3級，將大小小於5公分的狀況判定為4級，且將未確認到反射光環的狀況判定為5級。The halo reflected by the light installed at a height of 1 meter from the head of the subject was confirmed. The size of the aura of light reflected by light based on a photograph (size: 3 cm x 4 cm) of the head taken under the conditions mentioned above (70 to 80% of the total area of the photo) A condition of 15 cm or more and 15 cm or more to less than 20 cm is judged to be level 1, and a condition of 10 cm or more or more than 10 cm to less than 15 cm is judged to be level 2, and the size is 5 cm or more and 5 cm or less. The condition of 10 cm was judged to be 3 levels, and the condition of the size of less than 5 cm was judged to be 4 levels, and the state in which the reflected aura was not confirmed was determined to be 5 levels.
（量測紅斑的方法）(Method of measuring erythema)
基於藉由對頭皮狀態攝影而獲得的相片，使用IMAGE pro將頭皮的紅斑程度指示為數值。此處，將紅斑程度小於20%的狀況判定為1級，將紅斑程度為20%或大於20%至小於40%的狀況判定為2級，將紅斑程度為40%或大於40%至小於60%的狀況判定為3級，將紅斑程度為60%或大於60%至小於80%的狀況判定為4級，且將紅斑程度為80%或大於80%的狀況判定為5級。Based on the photograph obtained by photographing the scalp state, the degree of erythema of the scalp is indicated as a numerical value using IMAGE pro. Here, the condition in which the degree of erythema is less than 20% is judged as level 1, and the condition in which the degree of erythema is 20% or more than 20% to less than 40% is judged as level 2, and the degree of erythema is 40% or more than 40% to less than 60. The condition of % was judged to be 3, and the condition in which the degree of erythema was 60% or more than 60% to less than 80% was judged as 4, and the condition in which the degree of erythema was 80% or more was judged to be 5th.
（枯糙）(rough)
當研究人員用手向下撫摸受試者的頭髮時，依據感覺來評估枯糙程度，且將頭髮感覺為顯著柔軟的狀況評估為1級，將頭髮部分地稍微枯糙但大部分感覺柔軟的狀況評估為2級，將頭髮感覺為整體稍微枯糙的狀況評估為3級，將頭髮感覺為全部枯糙的狀況評估為4級，且將頭髮感覺為顯著枯糙的狀況評估為5級。When the researchers stroked the subject's hair down by hand, the degree of roughness was evaluated based on the sensation, and the condition in which the hair felt significantly soft was evaluated as level 1, and the hair was partially slightly rough but mostly felt soft. The condition was evaluated as level 2, and the condition in which the hair felt as a whole slightly rough was evaluated as level 3, the condition in which the hair was felt to be completely rough was evaluated as level 4, and the condition in which the hair was perceived to be significantly rough was evaluated as level 5.
（皮脂）(sebum)
用油紙吸附頭皮的皮脂，且用光學方式評估吸附程度並使用皮脂儀（MPA580，C+K，德國）將其指示為數值。在此狀況下，吸附程度在0至350（單位：微克/平方公分）的範圍內。此處，數值愈高，則被吸附皮脂的量愈大。The sebum of the scalp was adsorbed with oily paper, and the degree of adsorption was optically evaluated and indicated as a numerical value using a sebum meter (MPA580, C+K, Germany). In this case, the degree of adsorption is in the range of 0 to 350 (unit: microgram/cm 2 ). Here, the higher the value, the larger the amount of sebum adsorbed.
（水分）(moisture)
使用藉由德麥隆（DermaLab）（皮層技術（Cortex Technology），丹麥）量測電導率的原理來量測角質層的保水力。The water retention of the stratum corneum was measured using the principle of measuring conductivity by DermaLab (Cortex Technology, Denmark).
（頭髮密度）(hair density)
使用分析程式將使用弗雷斯科（Folliscope）（利德曼（LEADM），韓國）以60倍放大率攝取的相片中的頭髮的數目指示為數值。Using the analysis program, the number of hairs in a photograph taken at 60 times magnification using Folliscope (LEADM, Korea) is indicated as a numerical value.
（頭髮直徑）(hair diameter)
使用分析程式將使用弗雷斯科（利德曼，韓國）以300倍放大率攝取的相片中的頭髮的橫截面指示為數值。Using the analysis program, the cross section of the hair in the photograph taken at Fresco (Lederman, Korea) at 300 times magnification is indicated as a numerical value.
（捲曲）(curly)
藉由用裸眼評估頭髮的扭曲及波浪程度來評估捲髮。將不存在捲髮且頭髮完全為直的狀況評估為1級，將一些頭髮捲曲但頭髮完全為直的狀況評估為2級，將頭髮以具有大約2公分的直徑的彈簧的形式扭曲的狀況評估為3級，將頭髮以具有大約1公分的直徑的彈簧的形式扭曲的狀況評估為4級，且將頭髮以具有大約0.5公分的直徑的彈簧的形式扭曲的狀況評估為5級。The curls were evaluated by assessing the distortion and waveiness of the hair with the naked eye. The condition in which no curls were present and the hair was completely straight was evaluated as level 1, and the condition in which some hair was curled but the hair was completely straight was evaluated as level 2, and the condition in which the hair was twisted in the form of a spring having a diameter of about 2 cm was evaluated as At the third level, the condition in which the hair was twisted in the form of a spring having a diameter of about 1 cm was evaluated as 4, and the condition in which the hair was twisted in the form of a spring having a diameter of about 0.5 cm was evaluated as 5 steps.
（色差）(color difference)
在使用分光光度計CM-2600d（美能達（Minolta），日本）獲得作為波長函數的頭髮光源在與頭皮隔開3公分的部位處的光譜功率分佈或反射物件的光譜反射比之後，自其計算樣本的色度座標，將頭髮的亮度指示為L*值，將紅度指示為a*值，且將黃度指示為b*值。After using the spectrophotometer CM-2600d (Minolta, Japan), the hair source as a function of wavelength is obtained from the spectral power distribution at the position separated from the scalp by 3 cm or the spectral reflectance of the reflective object. The chromaticity coordinates of the sample indicate the brightness of the hair as the L* value, the redness as the a* value, and the yellowness as the b* value.
（皮屑）(dandruff)
藉由裸眼使用利用弗雷斯科（利德曼，韓國）以60倍放大率攝取的相片來評估皮屑程度。此處，將皮屑程度小於20%的狀況判定為1級，將皮屑程度為20%或大於20%至小於40%的狀況判定為2級，將皮屑程度為40%或大於40%至小於60%的狀況判定為3級，將皮屑程度為60%或大於60%至小於80%的狀況判定為4級，且將皮屑程度為80%或大於80%的狀況判定為5級。The degree of dander was evaluated by naked eye using a photograph taken at 60 times magnification by Fresco (Lidman, Korea). Here, the condition in which the degree of dander is less than 20% is judged as level 1, and the condition in which the degree of dander is 20% or more than 20% to less than 40% is judged as level 2, and the degree of dander is 40% or more. The condition to be less than 60% is judged to be 3, the condition in which the degree of dander is 60% or more than 60% to less than 80% is judged as 4, and the condition in which the degree of dander is 80% or more is judged as 5 level.
步驟2。Step 2.
使用一種統計軟體IBM SPSS Statistics 20.0（IBM）。任意地選擇如上文所描述量測的受試者（200個人）的結果，且基於此等評估類別的結果值執行回歸分析，藉此獲得對應於指示顯著性等級的值的p值。使用分析結果，以對老化具有高影響至低影響（β值）的順序自與老化相關的評估類別提取7個評估類別（脫髮、灰髮、光澤度、水分、頭髮密度、頭髮直徑以及紅斑)（參見表1）。Use a statistical software IBM SPSS Statistics 20.0 (IBM). The results of the subjects (200 individuals) measured as described above were arbitrarily selected, and a regression analysis was performed based on the result values of the evaluation categories, thereby obtaining a p value corresponding to the value indicating the significance level. Using the results of the analysis, 7 evaluation categories (hair loss, gray hair, gloss, moisture, hair density, hair diameter, and erythema) were extracted from the aging-related evaluation categories in the order of high to low (β value) for aging. (See Table 1).
步驟3。Step 3.
使用一種統計軟體IBM SPSS Statistics 20.0（IBM）執行多元線性回歸分析。使用分析結果，選擇對應於有效評估類別的組合的脫髮、灰髮、光澤度以及紅斑的組合（參見表2）。Multiple linear regression analysis was performed using a statistical software IBM SPSS Statistics 20.0 (IBM). Using the results of the analysis, a combination of hair loss, gray hair, gloss, and erythema corresponding to the combination of the effective evaluation categories was selected (see Table 2).
步驟4。Step 4.
藉由基於關於脫髮、灰髮、光澤度以及紅斑的資料（參見表3）中的每一者執行回歸分析來推論以下方程式。The following equations are inferred by performing regression analysis based on each of the data on hair loss, gray hair, gloss, and erythema (see Table 3).
[方程式] (頭皮及頭髮的年齡指數) =(35.927)+(2.337)´(脫髮級別)+(3.458)´(灰髮級別)+(1.068) ´(光澤度級別)=(0.150)´(紅斑級別)[Equation] (age index of scalp and hair) = (35.927) + (2.337) ́ (hair loss level) + (3.458) ́ (gray hair level) + (1.068) ́ (gloss level) = (0.150) ́ ( Erythema level)
（表1）
（表2）
自表1選擇具有0.05或小於0.05的p值（亦即，與年齡顯著相關）同時具有±0.3或大於0.3的皮爾森相關係數的5個類別（脫髮，灰髮、光澤度、頭髮密度以及紅斑），且執行多元回歸分析。選擇p值（顯著性機率）在0.05或小於0.05的範圍外且部分相關係數為低的頭髮密度作為省略變數，以藉此將其排除。Table 5 was selected from 5 categories with a p value of 0.05 or less (i.e., significantly associated with age) with a Pearson correlation coefficient of ±0.3 or greater (hair loss, gray hair, gloss, hair density, and erythema) ) and perform multiple regression analysis. A hair density whose p value (significance probability) is outside the range of 0.05 or less and the partial correlation coefficient is low is selected as an omission variable to thereby exclude it.
（表3）
使用除部分相關係數為低的頭髮密度外的四個參數（脫髮、灰髮、光澤度以及紅斑）執行多元回歸分析，藉此獲得表3中所說明的以下結果。Multiple regression analysis was performed using four parameters (hair loss, gray hair, gloss, and erythema) except for a hair density with a partial correlation coefficient being low, whereby the following results explained in Table 3 were obtained.
此外，作為使用根據本發明推論的方程式確認處在20歲至60歲的受試者的年齡指數的平均值的結果，可瞭解，處在20歲的受試者具有對應於44.01的值，處在30歲的受試者具有對應於46.31的值，處在40歲的受試者具有對應於47.80的值，且處在50歲的受試者具有對應於50.98的值，且處在60歲的受試者具有對應於55.62的值，且數值愈大，年齡指數愈高。如上文所描述的年齡指數的平均值可根據得到額外資料庫而顯著改變，藉此使得可進一步改良結果可靠性。Further, as a result of using the equation deduced according to the present invention to confirm the average value of the age index of the subjects aged 20 to 60, it can be understood that the subject at 20 years old has a value corresponding to 44.01, The subject at 30 years old has a value corresponding to 46.31, the subject at 40 years old has a value corresponding to 47.80, and the subject at 50 years old has a value corresponding to 50.98 and is at 60 years old. The subject has a value corresponding to 55.62, and the larger the value, the higher the age index. The average of the age indices as described above can vary significantly depending on the availability of additional databases, thereby making it possible to further improve the reliability of the results.
（實例2）(Example 2)
使用上文在實例1中推論的方程式量測10個受試者在治療之前的頭皮及頭髮的年齡指數。此後，在用具有表4中所說明的組合物的洗髮精治療頭皮及頭髮之後，量測在治療之後的頭皮及頭髮的年齡指數。使用量測到的值計算在治療之前及之後的平均值及偏差，藉此評估頭皮及頭髮上的抗老化效應（參見表5）。The age indices of the scalp and hair of the 10 subjects prior to treatment were measured using the equations deduced in Example 1 above. Thereafter, after treating the scalp and hair with shampoo having the composition described in Table 4, the age index of the scalp and hair after the treatment was measured. The measured values were used to calculate the mean and deviation before and after treatment to assess the anti-aging effects on the scalp and hair (see Table 5).
（表4）
（表5）
如表5中所說明，作為比較在使用髮用化妝品組合物之前及之後的頭皮及頭髮的年齡指數的結果，可瞭解，頭皮及頭髮上的抗老化效應為優良的，且p值為0.001或小於0.001，以使得結果具有高可靠性。此外，如表3中所說明，在根據本發明的回歸分析中，確認F為99.062（p值=0.001），其為在統計上顯著的，且瞭解到，指示回歸分析模型的R平方的調整的R2 值為0.361，以使得回歸分析具有高可靠性。As shown in Table 5, as a result of comparing the age indexes of the scalp and hair before and after the use of the hair cosmetic composition, it is understood that the anti-aging effect on the scalp and the hair is excellent, and the p value is 0.001 or Less than 0.001, so that the result has high reliability. Furthermore, as illustrated in Table 3, in the regression analysis according to the present invention, it was confirmed that F was 99.062 (p value = 0.001), which was statistically significant, and it was understood that the adjustment of the R square of the regression analysis model was indicated. The R 2 value was 0.361 to make the regression analysis highly reliable.
亦即，可使用根據本發明的評估方法定量地評估在使用髮用化妝品組合物之前及之後的頭皮及頭髮上的抗老化效應以及頭皮及頭髮的老化程度，以使得根據本發明的方法可用作在未來研發產品時適用的指示物。That is, the anti-aging effect on the scalp and hair and the degree of aging of the scalp and hair before and after the use of the hair cosmetic composition can be quantitatively evaluated using the evaluation method according to the present invention, so that the method according to the present invention can be used. As an indicator for future development of products.
根據本發明，可提供一種能夠藉由使用基於自各種年齡的受試者累積的資料以統計方式計算的方程式全面地評估頭皮及頭髮的老化程度而不取決於視覺評估的高可靠性評估方法。According to the present invention, it is possible to provide a high reliability evaluation method capable of comprehensively evaluating the degree of aging of the scalp and hair without using a visual evaluation by using a statistically calculated equation based on data accumulated from subjects of various ages.
另外，可藉由計算個人的頭皮及頭髮的年齡指數及比較計算出的年齡指數與資料庫的年齡指數來評估老化程度，且可藉由比較在對同一人員使用髮用化妝品之前及之後的年齡指數來全面且客觀地評估髮用化妝品的效果。In addition, the degree of aging can be assessed by calculating the age index of the individual's scalp and hair and comparing the calculated age index with the age index of the database, and by comparing the ages before and after the use of the applied cosmetics for the same person. The index provides a comprehensive and objective assessment of the effectiveness of hair cosmetics.
根據本發明的評估頭皮及頭髮的老化程度的方法可進一步藉由將關於新受試者的資料庫添加至所累積資料以更新資料庫來改良結果可靠性。The method for assessing the degree of aging of the scalp and hair according to the present invention can further improve the reliability of the result by adding a database of new subjects to the accumulated data to update the database.
無no
圖1說明頭髮中的脫髮程度的定級準則。 圖2說明頭髮中的灰髮程度的定級準則。 圖3說明頭髮中的光澤程度的定級準則。 圖4說明頭皮的紅斑程度的定級準則。Figure 1 illustrates the grading criteria for the degree of hair loss in the hair. Figure 2 illustrates the grading criteria for the degree of gray hair in the hair. Figure 3 illustrates the grading criteria for the degree of gloss in the hair. Figure 4 illustrates the grading criteria for the degree of erythema in the scalp.
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