TW200738717A - Manufacturing method of carbapenem derivative by continuous reaction - Google Patents

Manufacturing method of carbapenem derivative by continuous reaction

Info

Publication number
TW200738717A
TW200738717A TW095130335A TW95130335A TW200738717A TW 200738717 A TW200738717 A TW 200738717A TW 095130335 A TW095130335 A TW 095130335A TW 95130335 A TW95130335 A TW 95130335A TW 200738717 A TW200738717 A TW 200738717A
Authority
TW
Taiwan
Prior art keywords
compound
iii
protecting group
manufacturing
continuous reaction
Prior art date
Application number
TW095130335A
Other languages
Chinese (zh)
Inventor
Kenji Kanamoto
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of TW200738717A publication Critical patent/TW200738717A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an industrially useful method for preparing carbapenem derivatives. The present invention provides a method for preparing a compound (V), its solvate or the crystal of the solvate, which is characterized by comprising following steps: (step1) reacting a compound (I) with a metallic catalyst in a solvent to produce a compound (II); (step2) mixing the reacted solution containing the compound (II) obtained from the step1, diphenyl phosphochloridate and an alkali to produce a compound (III); and (step3) mixing the reacted solution containing the compound (III) obtained from the step 2 and a compound (IV) or the salt thereof to synthesis a compound (V); (wherein, R1 represents a carboxyl protecting group; R2represents a hydrogen atom or a hydroxyl protecting group; R3represents a hydrogen atom or an amino protecting group ; provided that both of the compound (II) and the compound (III) have not to be isolated).
TW095130335A 2005-08-19 2006-08-18 Manufacturing method of carbapenem derivative by continuous reaction TW200738717A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005238243A JP2008303143A (en) 2005-08-19 2005-08-19 Method for producing carbapenem derivative by continuous reaction

Publications (1)

Publication Number Publication Date
TW200738717A true TW200738717A (en) 2007-10-16

Family

ID=37757617

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095130335A TW200738717A (en) 2005-08-19 2006-08-18 Manufacturing method of carbapenem derivative by continuous reaction

Country Status (3)

Country Link
JP (1) JP2008303143A (en)
TW (1) TW200738717A (en)
WO (1) WO2007020960A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932381B2 (en) * 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
CN101613351B (en) * 2008-06-24 2011-10-19 上海医药工业研究院 Methanol solvate of doripenem intermediate and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0699434B2 (en) * 1980-05-01 1994-12-07 メルク エンド カムパニー インコーポレーテッド Process for producing intermediates of 1-carbapenems via 4-allylazetidinone
JPS57123182A (en) * 1980-12-18 1982-07-31 Merck & Co Inc 6- and 4-substituted-1-azabicyclo(3,1,2,0)heptane- 3,7-dione-2-carboxylate
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
JP3479720B2 (en) * 1992-07-08 2003-12-15 武田薬品工業株式会社 Method for producing carbapenems
GB9324725D0 (en) * 1993-12-02 1994-01-19 Fujisawa Pharmaceutical Co Ficyclic compounds and preparation thereof
JP4274739B2 (en) * 2001-05-10 2009-06-10 塩野義製薬株式会社 Method for producing acetylthiopyrrolidine derivatives

Also Published As

Publication number Publication date
WO2007020960A1 (en) 2007-02-22
JP2008303143A (en) 2008-12-18

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