TW200732308A - Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof - Google Patents

Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof

Info

Publication number
TW200732308A
TW200732308A TW095137552A TW95137552A TW200732308A TW 200732308 A TW200732308 A TW 200732308A TW 095137552 A TW095137552 A TW 095137552A TW 95137552 A TW95137552 A TW 95137552A TW 200732308 A TW200732308 A TW 200732308A
Authority
TW
Taiwan
Prior art keywords
alkylene
alkyl
aryl
optionally substituted
nrarb
Prior art date
Application number
TW095137552A
Other languages
Chinese (zh)
Inventor
Jean Michel Augereau
Gilles Courtemanche
Pierre Despeyroux
Michel Geslin
Anne Thomas
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36645639&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200732308(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of TW200732308A publication Critical patent/TW200732308A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

The invention relates to 4-aminoquinazoline derivatives of general formula (I), in which: A, B = optionally substituted C1-4-alkylene; L = single bond, C1-2-alkylene, -CH=CH- or -C≡C-; the groups C1-2-alkylene and -CH=CH- being optionally substituted, or L = cyctoprop-1,2-diyl;R = H, C1-5-alkyl, C1-3-fluoroalkyl, C3-6-cydoalkyl, - C(O)C1-3-alkyl, C1-3-alkylene-C3-6-cycloalkyl, -CH2-C≡CH, C2-4-alkylene-NRaRb or C1-3-alkylene-X-C1-3-alkyl in which X = O, SO2; R1 = aryl or heteroaryl; optionally substituted; R2 and R3 = H, C1-3-alkyl or C1-3-fluoroalkyl, or alternatively R2 and R3 together form a cycloprop-1,1-diyl; R4 = H, C1-5-alkyl, C1-3-fluoroalkyl, C1-5-alkoxy, -SF5, C1-3-alkylene-X-C1-3-alkyl in which X = O or SO2, C1-5-alkylene-NRaRb, an aryl or a heteroaryl, which are optionally substituted; R5 = H, halogen, C1-5-alkyl, C1-3-fluoroalkyl, C1-5-alkoxy, C3-6-cycloalkyl, C1-3-alkylene-C3-6-cycloalkyl, C1-3-alkylene-O-C1-3-alkyl, C1-3-alkylene-(OH) or C1-3-alkylene-X-C1-3-alkyl in which X = S, SO or SO2, or alternatively R5 = -NRaRb, C1-3-alkylene-NRaRb, aryl, C1-3-alkylene-aryl, -O-aryl, C1-3-alkylene-O-aryl, C1-3-alkylene-O-C1-3-alkylene-aryl, heteroaryl or C1-3-alkylene-heteroaryl, which are optionally substituted, or R5 = heterocycle optionally substituted with C1-3-alkyl, -C(O)C1-3-alkyl, -C(O)C1-3-fluoroalkyl, C1-3-alkylene-C3-6-cycloalkyl, C1-3-alkylene-aryl, C1-3-alkylene-heteroaryl, which are optionally substituted; R7 = H, halogen, C1-5-alkyl, C1-3-fluoroalkyl, C1-5-alkoxy, -COOH, -C(O)O-C1-3-alkyl, C1-3-fluoroalkoxy, C1-3-alkylene-(OH), -NO2, -CN or -X-C1-3-alkyl in which X represents S, SO or SO2, or alternatively R7 = -NRaRb, C1-3-alkylene-NRaRb, -C(O)-NRaRb, -C(o)-C1-3-alkyl, aryl, -O-aryl or heteroaryl, which are optionally substituted; in the form of base or of acid-addition salt, and also in the form of hydrate or solvate.
TW095137552A 2005-10-12 2006-10-12 Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof TW200732308A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0510409A FR2891829A1 (en) 2005-10-12 2005-10-12 4-AMINO-QUINAZOLINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF

Publications (1)

Publication Number Publication Date
TW200732308A true TW200732308A (en) 2007-09-01

Family

ID=36645639

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095137552A TW200732308A (en) 2005-10-12 2006-10-12 Substituted 4-aminoquinazoline derivatives, preparation thereof and therapeutic application thereof

Country Status (5)

Country Link
AR (1) AR056688A1 (en)
FR (1) FR2891829A1 (en)
TW (1) TW200732308A (en)
UY (1) UY29857A1 (en)
WO (1) WO2007042669A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2009108280A (en) 2006-08-08 2010-09-20 Санофи-Авентис (Fr) Arylamino-arylalkyl-substituted imidazolidine-2,4-dione, methods for their preparation containing these compounds and their use
AU2009249246A1 (en) 2008-05-22 2009-11-26 Allergan, Inc. Bicyclic compounds having activity at the CXCR4 receptor
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2011023754A1 (en) 2009-08-26 2011-03-03 Sanofi-Aventis Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
EP2683704B1 (en) 2011-03-08 2014-12-17 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP3302057A4 (en) * 2015-06-04 2018-11-21 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
BR112018068702A2 (en) 2016-03-16 2019-01-15 Kura Oncology Inc menin-mll bridged bicyclic inhibitors and methods of use
EP3429591B1 (en) 2016-03-16 2023-03-15 Kura Oncology, Inc. Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use
WO2018175746A1 (en) 2017-03-24 2018-09-27 Kura Oncology, Inc. Methods for treating hematological malignancies and ewing's sarcoma
WO2018226976A1 (en) 2017-06-08 2018-12-13 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
TW201920170A (en) 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 Substituted inhibitors of MENIN-MLL and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126087A1 (en) * 1982-09-24 1984-11-28 Beecham Group Plc Amino-azabicycloalkyl derivatives as dopamine antagonists
GB2295387A (en) * 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
WO2003028641A2 (en) * 2001-10-01 2003-04-10 Taisho Pharmaceutical Co., Ltd. Mch receptor antagonists
EP1534703A2 (en) * 2002-06-12 2005-06-01 Abbott Laboratories Antagonists of melanin concentrating hormone receptor
WO2004052371A2 (en) * 2002-12-11 2004-06-24 7Tm Pharma A/S Cyclic quinoline compounds for use in mch receptor related disorders
CL2004000409A1 (en) * 2003-03-03 2005-01-07 Vertex Pharma COMPOUNDS DERIVED FROM 2- (REPLACED CILO) -1- (AMINO OR REPLACED OXI) -CHINAZOLINE, INHIBITORS OF IONIC SODIUM AND CALCIUM VOLTAGE DEPENDENTS; PHARMACEUTICAL COMPOSITION; AND USE OF THE COMPOUND IN THE TREATMENT OF ACUTE PAIN, CHRONIC, NEU
KR20060079121A (en) * 2004-12-31 2006-07-05 에스케이케미칼주식회사 Quinazoline derivatives for the treatment or prevention of diabetes and obesity

Also Published As

Publication number Publication date
UY29857A1 (en) 2007-05-31
AR056688A1 (en) 2007-10-17
WO2007042669A2 (en) 2007-04-19
WO2007042669A3 (en) 2007-05-31
FR2891829A1 (en) 2007-04-13

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