TW200730500A - 4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators - Google Patents

4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators

Info

Publication number
TW200730500A
TW200730500A TW095147172A TW95147172A TW200730500A TW 200730500 A TW200730500 A TW 200730500A TW 095147172 A TW095147172 A TW 095147172A TW 95147172 A TW95147172 A TW 95147172A TW 200730500 A TW200730500 A TW 200730500A
Authority
TW
Taiwan
Prior art keywords
compounds
cannabinoid
dihydro
receptor modulators
methods
Prior art date
Application number
TW095147172A
Other languages
Chinese (zh)
Inventor
Josephus H M Lange
Van Der Neut
Bakker Wouter I Iwema
Van Vliet
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of TW200730500A publication Critical patent/TW200730500A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Abstract

This invention is directed to 4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor modulators, to pharmaceutical compositions containing these compounds, to methods for the preparation of these compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in disorders in which CB1 receptors are involved, or that can be treated via manipulation of those receptors. The compounds have the general formula (I), wherein the symbols have the meanings given in the specification.
TW095147172A 2005-12-20 2006-12-15 4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators TW200730500A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05112482 2005-12-20

Publications (1)

Publication Number Publication Date
TW200730500A true TW200730500A (en) 2007-08-16

Family

ID=35749602

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095147172A TW200730500A (en) 2005-12-20 2006-12-15 4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators

Country Status (8)

Country Link
CN (1) CN101341127A (en)
AR (1) AR058370A1 (en)
AT (1) ATE500228T1 (en)
BR (1) BRPI0620035A2 (en)
DE (1) DE602006020489D1 (en)
SA (1) SA06270469B1 (en)
TW (1) TW200730500A (en)
ZA (1) ZA200804926B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR079935A1 (en) 2010-01-29 2012-02-29 Abbott Healthcare Products Bv SYNTHESIS OF DERIVATIVES OF PIRAZOLIN CARBOXAMIDINA REPLACED
MX2013007952A (en) * 2011-01-07 2013-08-21 Targacept Inc Nicotinic receptor non-competitive antagonists.
CN107417578B (en) * 2017-08-23 2020-02-07 沈阳海诺威医药科技有限公司 N- (3, 5-dimethyl adamantane-1-yl) -N' -substituted phenylurea compound and preparation method and application thereof

Also Published As

Publication number Publication date
SA06270469B1 (en) 2010-07-25
BRPI0620035A2 (en) 2011-10-25
ATE500228T1 (en) 2011-03-15
ZA200804926B (en) 2009-04-29
AR058370A1 (en) 2008-01-30
CN101341127A (en) 2009-01-07
DE602006020489D1 (en) 2011-04-14

Similar Documents

Publication Publication Date Title
HK1092152A1 (en) Processes for preparing substituted n-aryl-n'-[3-(1h-pyrazol-5-yl)phenyl] ureas and intermediates thereof
NO20083193L (en) 4,5-Dihydro- (1H) -pyrazole derivatives as cannabinoid CB1 receptor modulators
GEP20135907B (en) L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators
SI1713475T1 (en) 1,3,5-trisubstituted 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
HK1154587A1 (en) Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
WO2005080343A3 (en) 3-substituted 1,5-diphenylpyrazole derivatives useful as cb1 modulators
WO2006067428A3 (en) 1, 2-diphenyl-imidazole derivatives and their use as cb1 receptor ligands
WO2009010455A3 (en) Pyrazole derivatives as modulators of metabotropic glutamate receptors
MY146662A (en) Novel n-(8-heteroaryltetrahydronaphtalene-2yl) or n-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain
UA99524C2 (en) Triazole derivatives useful for the treatment of diseases
TW200637827A (en) Processes for preparing substituted phenylpyrazole ureas
NZ595759A (en) Substituted phenylureas and phenylamides as vanilloid receptor ligands
MY149855A (en) Benzimidazole derivatives and their use for modulating the gaba? receptor complex
DK1725536T3 (en) Imidazoline derivatives with CB1 antagonistic activity
GB0519760D0 (en) Novel compounds
ATE407119T1 (en) PYRIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF THE CB2 RECEPTOR
IL173436A0 (en) 1h-imidazole derivatives as cannabinoid receptor modulators
TW200730500A (en) 4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators
WO2009037244A3 (en) 5-aryl-4,5-dihydro-(1h)-pyrazoles as cannabinoid cb1 receptor agonists
MX2010003059A (en) 5-aryl-4,5-dihydro-(1h)-pyrazoles as cannabinoid cb1 receptor agonists.
WO2009117283A3 (en) Quinolizidinone m1 receptor positive allosteric modulators
WO2008152086A3 (en) 4,5-dihydro-(1h)-pyrazole derivatives as cannabinoid cb1 receptor modulators
UA92736C2 (en) 1h-imidazole derivatives as cannabinoid cb2 receptor modulators
MX2009013677A (en) 4,5-dihydro-(1h)-pyrazole derivatives as cannabinoid cb1 receptor modulators.
IL195969A0 (en) Azaindole derivatives with a combination of partial nicotinic acetylcholine receptor agonism and dopamine reuptake inhibition