TW200621310A - A process for preparing formulations of lypophilic active substances by spray freeze drying - Google Patents

A process for preparing formulations of lypophilic active substances by spray freeze drying

Info

Publication number
TW200621310A
TW200621310A TW094138791A TW94138791A TW200621310A TW 200621310 A TW200621310 A TW 200621310A TW 094138791 A TW094138791 A TW 094138791A TW 94138791 A TW94138791 A TW 94138791A TW 200621310 A TW200621310 A TW 200621310A
Authority
TW
Taiwan
Prior art keywords
mixture
sugar
sugars
dissolved
lypophilic
Prior art date
Application number
TW094138791A
Other languages
Chinese (zh)
Inventor
Drooge Dirk J Van
Wouter L J Hinrichs
Henderik W Frijlink
Gerrit Sietse Zijlstra
Bastiaan Dickhoff
Original Assignee
Univ Groningen
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Groningen, Solvay Pharm Bv filed Critical Univ Groningen
Publication of TW200621310A publication Critical patent/TW200621310A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is related to a method for the preparation of a pharmaceutical composition comprising a lipophilic compound and a glass of a sugar, a sugar alcohol, a mixture of sugars or a mixture of sugars alcohols, wherein the lipophilic compound is incorporated in the sugar glass, characterized in that a. said lipophilic compound is dissolved in an organic solvent that is miscible with water and said sugar, sugar alcohol, mixture of sugars or mixture of sugar alcohols is dissolved in water; b. the dissolved lipophilic compound and the dissolved sugar, sugar alcohol, c. mixture of sugars or mixture of sugar alcohols are mixed in such a way that a homogeneous mixture is obtained; c. said mixture is spray freeze dried. The invention is further related to pharmaceutical formulations formed containing lipophilic compounds such as A9-tetrahydrocannabinol, diazepam and cyclosporin A.
TW094138791A 2004-11-10 2005-11-04 A process for preparing formulations of lypophilic active substances by spray freeze drying TW200621310A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04105661 2004-11-10

Publications (1)

Publication Number Publication Date
TW200621310A true TW200621310A (en) 2006-07-01

Family

ID=34929833

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094138791A TW200621310A (en) 2004-11-10 2005-11-04 A process for preparing formulations of lypophilic active substances by spray freeze drying

Country Status (7)

Country Link
EP (1) EP1811965A1 (en)
JP (1) JP5137579B2 (en)
CN (1) CN101056622A (en)
AR (1) AR052787A1 (en)
CA (1) CA2585314A1 (en)
TW (1) TW200621310A (en)
WO (1) WO2006051067A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1915987A1 (en) * 2006-10-27 2008-04-30 MediGene AG Spray-freeze-drying process for the preparation of pellets comprising percolation drying
JP2009149796A (en) * 2007-12-21 2009-07-09 National Univ Corp Shizuoka Univ Powdered oil and fat or composition containing powdered oil and fat, and agent therefor
JO3112B1 (en) * 2010-03-29 2017-09-20 Ferring Bv A fast dissolving pharmaceutical composition
US8758826B2 (en) * 2011-07-05 2014-06-24 Wet Inc. Cannabinoid receptor binding agents, compositions, and methods
CN102389095B (en) * 2011-10-14 2013-05-01 天津科技大学 System and method for preparing acidulant-oil microcapsules by low-temperature fluidized coating-granulation
WO2013139384A1 (en) 2012-03-21 2013-09-26 Dorkoosh, Farid Abedin Freezing of aerosolized solutions (fas): a system for continuous particle production
CN108379238B (en) * 2018-01-17 2020-07-14 南昌大学 Cyclosporin solid lipid nanoparticle with good storage physical stability and preparation method thereof
CN108159064B (en) * 2018-01-24 2020-09-04 广州中医药大学(广州中医药研究院) Supercritical anti-solvent breviscapine nano-particles and preparation method thereof, and breviscapine capsule and tablet
CN110269843A (en) * 2019-06-15 2019-09-24 云南飞久逍科技有限公司 A kind of cannabidiol CBD nano-emulsion freeze-dried powder and preparation method thereof
DE102019133243A1 (en) * 2019-12-05 2021-06-10 Rheinische Friedrich-Wilhelms-Universität Bonn Process for the production of spray-freeze-dried particles and correspondingly produced particles
CN112915121A (en) 2019-12-06 2021-06-08 汉义生物科技（北京）有限公司 Cannabinoid nano micelle preparation and preparation method thereof
MX2023000574A (en) * 2020-07-17 2023-03-14 Canna Chemistries Llc SOLID ο<sup>9</sup>-TETRAHYDROCANNABINOL (ο<sup>9</sup>-THC) COMPOSITIONS.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0773781T3 (en) * 1994-08-04 2004-02-16 Elan Drug Delivery Ltd Solid-state delivery systems for controlled release of molecules incorporated therein and methods for producing such systems
US5922253A (en) * 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
NL1012300C2 (en) * 1999-06-11 2000-12-12 Rijksuniversiteit Stabilizer for pharmaceuticals.
CA2436418A1 (en) * 2001-01-30 2002-08-08 Board Of Regents, The University Of Texas Systems Process for production of nanoparticles and microparticles by spray freezing into liquid
DE60324668D1 (en) * 2002-04-03 2008-12-24 Solvay Pharm Bv STABILIZED NATURAL CANNABINOID FORMULATION
KR20050011741A (en) * 2002-04-11 2005-01-29 메드이뮨 백신즈 인코포레이티드 Preservation of bioactive materials by spray drying
EP1428526A1 (en) * 2002-12-13 2004-06-16 Rijksuniversiteit Groningen Formulation for fast dissolution of lipophilic compounds

Also Published As

Publication number Publication date
WO2006051067A1 (en) 2006-05-18
JP2008519806A (en) 2008-06-12
AR052787A1 (en) 2007-04-04
JP5137579B2 (en) 2013-02-06
CA2585314A1 (en) 2006-05-18
CN101056622A (en) 2007-10-17
EP1811965A1 (en) 2007-08-01

Similar Documents

Publication Publication Date Title
TW200621310A (en) A process for preparing formulations of lypophilic active substances by spray freeze drying
WO2006089674A3 (en) Tablets with improved drug substance dispersibility
HK1078458A1 (en) Stabilized natural cannabinoid formulation and the prepation method thereof
WO2008007152A3 (en) Preparation of pharmaceutical formulations
BRPI0508579A (en) compound, pharmaceutical composition, and use of a compound
EA018545B1 (en) Therapeutic compositions
WO2006099187A3 (en) Benzoyl peroxide compositions and methods of use
WO2009107983A3 (en) Stabilized single-liquid pharmaceutical composition containing docetaxel
WO2006082501A3 (en) Fast wet-massing method for the preparation of calcium-containing compositions
KR101855919B1 (en) Active Material Stabilized in Plant Cell and Method for Manufacturing the Same
CN101678057A (en) Method for extracting secoisolariciresinol and dihydroquercetin from wood
CN105451728A (en) Agent for promoting in vivo absorption of hydroxytyrosol and derivatives thereof and use of same
DE602005019672D1 (en) Dried extract of rabbit vaccine vaccinated with vaccinia virus and process of preparation
KR100896500B1 (en) Transdermal composition for removing cellulite, cataplasma comprising the same and method for preparing thereof
WO2010020799A3 (en) Compositions for the treatment of neoplastic diseases
Cui et al. Studies on the active constituents in vine stem of Spatholobus suberectus
KR102325943B1 (en) Composition having improved light stability of peanut sprout extract
CN101023754A (en) Plant farm-chemical beadtree insect-killing agent of traditional Chinese herbs and preparing method
TR201910337A2 (en) CURCUMINOID ORAL COMPOUNDS WITH HIGH RESOLUTION AND BIO-ADJUSTMENT
TH79248A (en) The process for preparing formulated mixtures of fat-like active ingredients by aerosol freeze-drying.
TH79248B (en) The process for preparing formulated mixtures of fat-like active ingredients by drying in the freezing state in aerosol.
CN107028890A (en) A kind of characteristics of indomethacin solid dispersion
ITRM20080612A1 (en) ECO-COMPATIBLE BIOTECHNOLOGICAL PROCESS FOR TRANS-RESVERATROL EXTRACTION FROM VEGETABLE WASTE
TH70427A (en) Stabilized natural cannabinoid formula
CN106727522A (en) The imidazole radicals and bischloroethylamines radical derivative composition of Atropurpuran are used to prevent and treat pancreatic fibrosis