TW200514776A - Aminotriazole compounds useful as inhibitors of protein kinases - Google Patents

Aminotriazole compounds useful as inhibitors of protein kinases

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Publication number
TW200514776A
TW200514776A TW093123755A TW93123755A TW200514776A TW 200514776 A TW200514776 A TW 200514776A TW 093123755 A TW093123755 A TW 093123755A TW 93123755 A TW93123755 A TW 93123755A TW 200514776 A TW200514776 A TW 200514776A
Authority
TW
Taiwan
Prior art keywords
inhibitors
protein kinases
compounds useful
aminotriazole compounds
aminotriazole
Prior art date
Application number
TW093123755A
Other languages
English (en)
Inventor
Michael J Arnost
Guy W Bemis
Robert J Davies
Cornelia J Forster
Ronald Grey Jr
Mark W Ledeboer
Brian Ledford
Craig Marhefka
David Messersmith
Albert C Pierce
Francesco G Salituro
Jian Wang
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of TW200514776A publication Critical patent/TW200514776A/zh

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
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TW093123755A 2003-08-06 2004-08-06 Aminotriazole compounds useful as inhibitors of protein kinases TW200514776A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49278703P 2003-08-06 2003-08-06

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TW200514776A true TW200514776A (en) 2005-05-01

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Country Status (11)

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US (2) US7226920B2 (zh)
EP (1) EP1663211B1 (zh)
JP (1) JP4889489B2 (zh)
AR (1) AR045731A1 (zh)
AT (1) ATE455546T1 (zh)
AU (1) AU2004263148B2 (zh)
CA (1) CA2534921C (zh)
DE (1) DE602004025258D1 (zh)
PE (1) PE20050338A1 (zh)
TW (1) TW200514776A (zh)
WO (1) WO2005013982A1 (zh)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050338A1 (es) * 2003-08-06 2005-05-16 Vertex Pharma Compuestos de aminotriazoles como inhibidores de proteina quinasas
WO2005077938A1 (en) * 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MX2007003154A (es) * 2004-09-17 2007-05-15 Vertex Pharma Compuestos de diaminotriazol de utilidad como inhibidores de proteina quinasa.
TW200630090A (en) * 2004-10-21 2006-09-01 Vertex Pharma Triazoles useful as inhibitors of protein kinases
CN100334084C (zh) * 2005-04-26 2007-08-29 武汉大学 联***化合物及其制备方法和用途
US7576053B2 (en) 2005-06-13 2009-08-18 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders
HUE025466T2 (en) 2005-07-26 2016-02-29 Bial-Portela & Ca S A Nitro-pyrocatechin derivatives as comt inhibitors
EP1910384B1 (en) * 2005-08-04 2012-10-10 Sirtris Pharmaceuticals, Inc. Imidazo [2,1-b]thiazole derivatives as sirtuin modulating compounds
US7884119B2 (en) 2005-09-07 2011-02-08 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as Axl inhibitors
EP1845097A1 (en) 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
EP2061768A2 (en) * 2006-09-28 2009-05-27 Exelixis, Inc. Imidazole-4,5-dicarboxamide derivatives as jak-2 modulators
WO2008042639A1 (en) * 2006-10-02 2008-04-10 Irm Llc Compounds and compositions as protein kinase inhibitors
AU2007321719B2 (en) 2006-11-15 2013-11-21 Ym Biosciences Australia Pty Ltd Inhibitors of kinase activity
MX2009006170A (es) * 2006-12-11 2009-06-19 Irmc Llc Compuestos y composiciones como inhibidores de cinasa.
ES2607065T3 (es) 2006-12-29 2017-03-29 Rigel Pharmaceuticals, Inc. Triazoles N3-heteroaril sustituidos y triazoles N5-heteroaril sustituidos útiles como inhibidores de axl
ES2558477T3 (es) 2006-12-29 2016-02-04 Rigel Pharmaceuticals, Inc. Triazoles sustituidos útiles como inhibidores de AXL
WO2008083353A1 (en) 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors
WO2008083357A1 (en) 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
CN101622246B (zh) 2006-12-29 2015-09-30 里格尔制药公司 可用作axl抑制剂的多环杂芳基取代的***
KR101522157B1 (ko) 2007-01-31 2015-05-28 바이알 - 포르텔라 앤드 씨에이 에스에이 Ｃｏｍｔ 억제제의 투약 방법
EP2205592B1 (en) 2007-10-26 2013-05-08 Rigel Pharmaceuticals, Inc. Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors
WO2009116882A1 (en) 2008-03-17 2009-09-24 Portela & Ca., S.A. Crystal forms of 5- [3- (2, 5-dichloro-4, 6-dimethyl-1-oxy-pyridine-3-yl) [1,2,3] oxadiazol-5-yl] -3-nit robenzene-1, 2-diol
CA2730231C (en) 2008-07-09 2016-10-18 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as axl inhibitors
DK2328888T3 (da) 2008-07-09 2013-02-11 Rigel Pharmaceuticals Inc Broforbundne, bicykliske heteroarylsubstituerede triazoler, der er anvendelige som axl-inhitorer
WO2010078258A1 (en) * 2008-12-29 2010-07-08 The Board Of Trustees Of The University Of Alabama Compounds comprising two or more biologically functional ions and method of treating parkinson's disease
AU2010204578B2 (en) 2009-01-16 2016-05-12 Rigel Pharmaceuticals, Inc. AXL inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer
ES2730678T3 (es) 2009-04-01 2019-11-12 Bial Portela & Ca Sa Formulaciones farmacéuticas que comprenden derivados de nitrocatecol y métodos para fabricarlas
WO2011049625A1 (en) 2009-10-20 2011-04-28 Mansour Samadpour Method for aflatoxin screening of products
ES2651682T3 (es) 2009-11-05 2018-01-29 Rhizen Pharmaceuticals S.A. Moduladores de cinasa novedosos
WO2011144742A1 (en) 2010-05-21 2011-11-24 Chemilia Ab Novel pyrimidine derivatives
JP2012102090A (ja) * 2010-10-15 2012-05-31 Sumitomo Chemical Co Ltd ピリミジン化合物およびその有害生物防除用途
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
DK2688883T3 (en) 2011-03-24 2016-09-05 Noviga Res Ab pyrimidine
WO2012151525A1 (en) 2011-05-04 2012-11-08 Rhizen Pharmaceuticals Sa Novel compounds as modulators of protein kinases
CN102827073A (zh) * 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN103030646B (zh) * 2011-09-29 2016-08-24 上海恒瑞医药有限公司 苯并二氧六环类衍生物、其制备方法及其在医药上的应用
US9126988B2 (en) 2011-12-13 2015-09-08 Bial—Portela & Ca, S.A. Intermediate for preparing a catechol-O-methyltransferase inhibitor
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
ES2630705T3 (es) * 2012-01-13 2017-08-23 Bristol-Myers Squibb Company Compuestos de piridilo sustituidos con triazolilo útiles como inhibidores de cinasas
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
SG10201805807PA (en) 2012-06-26 2018-08-30 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
CA2876995C (en) 2012-07-04 2020-10-06 Rhizen Pharmaceuticals Sa Novel selective pi3k delta inhibitors
AU2014205483B2 (en) 2013-01-10 2017-11-30 Gilead Sciences, Inc. Non-selective kinase inhibitors
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
JP6529492B2 (ja) 2013-07-11 2019-06-12 アジオス ファーマシューティカルズ， インコーポレイテッド 癌の処置のためのｉｄｈ２突然変異体阻害剤としての２，４−または４，６−ジアミノピリミジン化合物
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
US9925184B2 (en) 2013-10-11 2018-03-27 Pulmokine, Inc. Spray-dry formulations
KR20240010105A (ko) 2014-03-14 2024-01-23 아지오스 파마슈티컬스 아이엔씨. 치료적으로 활성인 화합물의 약제학적 조성물
WO2016083863A1 (en) 2014-11-28 2016-06-02 Bial - Portela & Ca, S.A. Medicaments for slowing parkinson's disease
AU2016270373A1 (en) 2015-06-05 2018-01-04 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
BR112018007656A2 (pt) 2015-10-15 2018-11-06 Agios Pharmaceuticals Inc terapia de combinação para tratamento de doenças malignas
MX2018004587A (es) 2015-10-15 2018-08-14 Agios Pharmaceuticals Inc Terapia de combinacion para tratar tumores malignos.
SG11201808003RA (en) 2016-04-15 2018-10-30 Abbvie Inc Bromodomain inhibitors
JP2020500183A (ja) 2016-10-27 2020-01-09 プルモキネ、インコーポレイテッド 肺高血圧症の治療のための併用療法
WO2018106646A1 (en) * 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8429307D0 (en) 1984-11-20 1984-12-27 Shell Int Research Heterocyclic herbicides
US5801031A (en) * 1996-04-05 1998-09-01 Health Research, Incorporated Human and rat gamma glutamyl hydrolase genes
WO1999024440A1 (en) * 1997-11-11 1999-05-20 Pfizer Products Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
EP1112070B1 (en) * 1998-08-20 2004-05-12 Smithkline Beecham Corporation Novel substituted triazole compounds
JP2002528499A (ja) * 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物
US6596747B2 (en) * 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
US6124272A (en) * 1999-04-09 2000-09-26 Isis Pharmaceutical Inc. Antisense modulation of PDK-1 expression
FR2802530B1 (fr) * 1999-12-17 2002-02-22 Sanofi Synthelabo Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant
JP4105949B2 (ja) * 2000-09-15 2008-06-25 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼインヒビターとして有用なピラゾール化合物
CZ20031941A3 (cs) 2000-12-22 2004-08-18 Orthoámcneilápharmaceuticalźáinc Substituované triazol diaminové deriváty jako inhibitory kináz
DE10123586A1 (de) * 2001-05-08 2002-11-28 Schering Ag 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren
DE60314603T2 (de) * 2002-03-15 2008-02-28 Vertex Pharmaceuticals Inc., Cambridge Zusammensetzungen brauchbar als protein-kinase-inhibitoren
PE20050338A1 (es) * 2003-08-06 2005-05-16 Vertex Pharma Compuestos de aminotriazoles como inhibidores de proteina quinasas

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