TR201904638T4 - pKal aracılı rahatsızlıkların değerlendirilmesi, analizi ve tedavisi. - Google Patents
pKal aracılı rahatsızlıkların değerlendirilmesi, analizi ve tedavisi. Download PDFInfo
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- TR201904638T4 TR201904638T4 TR2019/04638T TR201904638T TR201904638T4 TR 201904638 T4 TR201904638 T4 TR 201904638T4 TR 2019/04638 T TR2019/04638 T TR 2019/04638T TR 201904638 T TR201904638 T TR 201904638T TR 201904638 T4 TR201904638 T4 TR 201904638T4
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- Prior art keywords
- pkal
- mediated
- evaluation
- treatment
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- 230000001404 mediated effect Effects 0.000 title abstract 5
- 238000004458 analytical method Methods 0.000 title abstract 3
- 238000011156 evaluation Methods 0.000 title abstract 2
- 102000003827 Plasma Kallikrein Human genes 0.000 abstract 2
- 108090000113 Plasma Kallikrein Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000028185 Angioedema Diseases 0.000 abstract 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- 108010080865 Factor XII Proteins 0.000 abstract 1
- 102000000429 Factor XII Human genes 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108010053400 protease Ci Proteins 0.000 abstract 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- C07K2317/00—Immunoglobulins specific features
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
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- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
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- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
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- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96455—Kallikrein (3.4.21.34; 3.4.21.35)
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Abstract
Buluş, plazma kallikrein, Faktör XII veya her ikisine bağlanan plazma proteaz CI inhibitörünün (CI-INH) saptanmasına ilişkin analiz yöntemlerini ve pKal aracılı veya bradikinin aracılık rahatsızlık riski bulunan veya bundan şikayet eden süjelerin tanımlanmasına yönelik kullanımlarını sağlar. Sağlanan yöntemler, plazma kallikrein aracılı anjiyoödem (KMA) veya pKal?nin aracılık ettiği diğer hastalıkları olan hastaların değerlendirmede ve tedavide faydalı olan analizine izin verir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361754600P | 2013-01-20 | 2013-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201904638T4 true TR201904638T4 (tr) | 2019-04-22 |
Family
ID=51210104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/04638T TR201904638T4 (tr) | 2013-01-20 | 2014-01-17 | pKal aracılı rahatsızlıkların değerlendirilmesi, analizi ve tedavisi. |
Country Status (21)
Country | Link |
---|---|
US (2) | US10690670B2 (tr) |
EP (2) | EP2946206B1 (tr) |
JP (3) | JP6656926B2 (tr) |
KR (3) | KR102419640B1 (tr) |
CN (2) | CN105452860B (tr) |
AU (3) | AU2014207409B2 (tr) |
CA (1) | CA2898446A1 (tr) |
CY (1) | CY1121872T1 (tr) |
DK (1) | DK2946206T3 (tr) |
ES (1) | ES2718347T3 (tr) |
HK (1) | HK1214361A1 (tr) |
HR (1) | HRP20190528T1 (tr) |
HU (1) | HUE044285T2 (tr) |
IL (1) | IL239957B (tr) |
LT (1) | LT2946206T (tr) |
PL (1) | PL2946206T3 (tr) |
PT (1) | PT2946206T (tr) |
RS (1) | RS58635B1 (tr) |
SI (1) | SI2946206T1 (tr) |
TR (1) | TR201904638T4 (tr) |
WO (1) | WO2014113701A1 (tr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE477020T1 (de) | 2002-06-07 | 2010-08-15 | Dyax Corp | Prevention und verringerung von ischemia |
CA3168591A1 (en) | 2010-01-06 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
JP2014506257A (ja) | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
WO2014113701A1 (en) | 2013-01-20 | 2014-07-24 | Dyax Corp. | Evaluation, assays and treatment of pkal-mediated disorders |
EP2964255B1 (en) * | 2013-03-08 | 2020-11-04 | CSL Behring GmbH | Treatment and prevention of remote ischemia-reperfusion injury |
JP2016513682A (ja) | 2013-03-15 | 2016-05-16 | ダイアックス コーポレーション | 抗血漿カリクレイン抗体 |
ES2856076T3 (es) | 2014-01-21 | 2021-09-27 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática y usos de las mismas en el tratamiento de angioedema hereditario |
KR102555955B1 (ko) * | 2014-03-27 | 2023-07-18 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
CN107405399B (zh) * | 2015-01-02 | 2022-02-08 | 武田药品工业株式会社 | 针对血浆激肽释放酶和因子xii的双特异性抗体 |
EP3302540A4 (en) * | 2015-05-28 | 2018-08-22 | Cornell University | Adeno-associated virus mediated delivery of c1ei as a therapy for angioedema |
CA2987103A1 (en) * | 2015-05-28 | 2016-12-01 | Cornell University | Adeno-associated virus mediated delivery of c1ei as a therapy for angioedema |
NZ739088A (en) | 2015-07-21 | 2024-01-26 | Takeda Pharmaceuticals Co | A monoclonal antibody inhibitor of factor xiia |
EP3387018A1 (en) | 2015-12-11 | 2018-10-17 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
NZ751481A (en) | 2016-09-16 | 2024-02-23 | Takeda Pharmaceuticals Co | Metabolite biomarkers for diseases associated with the contact activation system |
AU2017325983B2 (en) | 2016-09-16 | 2023-12-07 | Takeda Pharmaceutical Company Limited | Protein biomarkers for diseases associated with the contact activation system |
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