TR201903528T4 - Hiperamonyeminin saptanması için cihaz ve bu cihazı kullanma yöntemleri. - Google Patents

Hiperamonyeminin saptanması için cihaz ve bu cihazı kullanma yöntemleri. Download PDF

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Publication number
TR201903528T4
TR201903528T4 TR2019/03528T TR201903528T TR201903528T4 TR 201903528 T4 TR201903528 T4 TR 201903528T4 TR 2019/03528 T TR2019/03528 T TR 2019/03528T TR 201903528 T TR201903528 T TR 201903528T TR 201903528 T4 TR201903528 T4 TR 201903528T4
Authority
TR
Turkey
Prior art keywords
biosensor
detecting
ionomer
ammonia
whole blood
Prior art date
Application number
TR2019/03528T
Other languages
English (en)
Inventor
Bilal Ayyub Omar
Michael Behrens Adam
Kofinas Peter
Lynn Summar Marshall
Manuel CABRERA-LUQUE Juan
Cunningham Gary
Simeonov Anton
Marugan Juan
Original Assignee
Childrens Nat Medical Ct
Univ Maryland
Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Nat Medical Ct, Univ Maryland, Health filed Critical Childrens Nat Medical Ct
Publication of TR201903528T4 publication Critical patent/TR201903528T4/tr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plasma & Fusion (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

Mevcut buluş, bir iyonomer varlığında indofenol reaktifleri kullanılarak, bir veya çok sayıda amonyak veya amonyum iyonlarının toplam konsantrasyonunu ölçebilme özelliğine sahip olan bir biyosensörle ilgilidir. Bazı uygulamalarda, biyosensör, tam kan gibi bir numuneyi alacak şekilde konfigüre edilmiş bir kap içerisinde bir alkali tampon ile temas halinde bir iyonomer içeren bir perflorlu membran içerir. Buluş ayrıca, yaklaşık yirmi dakikadan daha uzun süren gaz kromatografisine ya da herhangi bir ölçüme ihtiyaç duymadan bir hasta başı biyosensöründe tam kandaki amonyak veya amonyum iyonu konsantrasyonunu saptamak veya bunun miktarını tayin etmek için bir yöntemle de ilgilidir.
TR2019/03528T 2013-08-30 2014-09-02 Hiperamonyeminin saptanması için cihaz ve bu cihazı kullanma yöntemleri. TR201903528T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361872149P 2013-08-30 2013-08-30

Publications (1)

Publication Number Publication Date
TR201903528T4 true TR201903528T4 (tr) 2019-04-22

Family

ID=52587421

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/03528T TR201903528T4 (tr) 2013-08-30 2014-09-02 Hiperamonyeminin saptanması için cihaz ve bu cihazı kullanma yöntemleri.

Country Status (15)

Country Link
US (2) US9952199B2 (tr)
EP (2) EP3540429B1 (tr)
JP (1) JP6646579B2 (tr)
KR (1) KR102278346B1 (tr)
CN (1) CN105940300B (tr)
AU (1) AU2014311977B2 (tr)
BR (1) BR112016004320B1 (tr)
CA (1) CA2922821C (tr)
CL (1) CL2016000467A1 (tr)
DK (2) DK3540429T3 (tr)
IL (1) IL244274B (tr)
MX (1) MX2016002632A (tr)
SA (1) SA516370640B1 (tr)
TR (1) TR201903528T4 (tr)
WO (1) WO2015031911A1 (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160092653A1 (en) * 2014-09-30 2016-03-31 Koninklijke Philips N.V. NUTRITIONAL INTAKE VIEWER (NutriWeb)
EP3289353A4 (en) 2015-04-27 2018-09-19 University of Maryland, College Park Device and methods of using device for detection of hyperammonemia
WO2017015154A1 (en) * 2015-07-17 2017-01-26 Children's National Medical Center Methods and compositions for treating phenyltonuria
US11026891B2 (en) 2016-08-16 2021-06-08 Eth Zurich Transmembrane pH-gradient polymersomes and their use in the scavenging of ammonia and its methylated analogs
KR101920272B1 (ko) * 2016-11-22 2018-11-20 (주)인트인 조명이 개선된 체액 검사장치
HRP20240464T1 (hr) * 2017-09-12 2024-07-05 Eth Zurich Eth Transfer Polimerzomi ph gradijenta transmembrane za kvantifikaciju amonijaka u tjelesnim tekućinama
ES2969886T3 (es) * 2018-01-12 2024-05-23 Mayo Found Medical Education & Res Sistemas y métodos para la detección y cuantificación de amoníaco y amonio en fluidos
US20220365059A1 (en) * 2019-09-20 2022-11-17 The Board Trustees Of The Leland Stanford Junior University Electrochemical pre-concentration for improved detection of gaseous species in water
CN110806448B (zh) * 2019-11-21 2022-03-22 北京市药品检验所 测定复方氨基酸注射液中游离氨的方法
KR102369697B1 (ko) * 2020-05-18 2022-03-03 국민대학교산학협력단 바이오 센싱 모듈, 바이오 센싱 장치, 및 이를 포함하는 바이오 센싱 시스템
EP3968009A1 (en) * 2020-09-10 2022-03-16 Hach Lange GmbH Method for determining ammonium
WO2023044381A1 (en) * 2021-09-16 2023-03-23 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
CN114088026B (zh) * 2022-01-20 2022-04-05 江苏奥琳斯邦装备科技股份有限公司 一种应变测量的热压固化装置以及固化方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5786053A (en) * 1980-11-18 1982-05-28 Yokogawa Hokushin Electric Corp Method and device for measuring amino compound
JPS59187249A (ja) * 1983-04-07 1984-10-24 Fuji Electric Corp Res & Dev Ltd 尿素窒素分析装置
JPS63218860A (ja) * 1987-03-07 1988-09-12 Aoki Hiroko 溶液中のアンモニアの定量方法
US5128015A (en) 1988-03-15 1992-07-07 Tall Oak Ventures Method and apparatus for amperometric diagnostic analysis
JP2739484B2 (ja) * 1988-09-29 1998-04-15 株式会社ヤトロン 自動分析装置用尿素窒素測定試薬
JPH02104272A (ja) * 1988-10-12 1990-04-17 Ricoh Co Ltd 液体検出装置
US4999632A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corporation Analog to digital conversion with noise reduction
US5243516A (en) 1989-12-15 1993-09-07 Boehringer Mannheim Corporation Biosensing instrument and method
US4999582A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corp. Biosensor electrode excitation circuit
US4963814A (en) 1989-12-15 1990-10-16 Boehringer Mannheim Corporation Regulated bifurcated power supply
DE4318519C2 (de) 1993-06-03 1996-11-28 Fraunhofer Ges Forschung Elektrochemischer Sensor
US5405511A (en) 1993-06-08 1995-04-11 Boehringer Mannheim Corporation Biosensing meter with ambient temperature estimation method and system
ES2153335T3 (es) 1993-06-08 2006-09-01 Roche Diagnostics Operations, Inc. Medidor biosensor que detecta el ajuste apropiado de los electrodos y distingue tiras de muestra y tiras de comprobacion.
US5366609A (en) 1993-06-08 1994-11-22 Boehringer Mannheim Corporation Biosensing meter with pluggable memory key
US5352351A (en) 1993-06-08 1994-10-04 Boehringer Mannheim Corporation Biosensing meter with fail/safe procedures to prevent erroneous indications
US5762770A (en) 1994-02-21 1998-06-09 Boehringer Mannheim Corporation Electrochemical biosensor test strip
US5981203A (en) * 1994-04-26 1999-11-09 The Regents Of The University Of Michigan Unitary sandwich enzyme immunoassay cassette, device and method of use
US5624537A (en) * 1994-09-20 1997-04-29 The University Of British Columbia - University-Industry Liaison Office Biosensor and interface membrane
US5698083A (en) 1995-08-18 1997-12-16 Regents Of The University Of California Chemiresistor urea sensor
JPH09271398A (ja) * 1996-02-09 1997-10-21 Asahi Chem Ind Co Ltd アンモニア測定法および測定用組成物
JP2000146899A (ja) 1998-11-06 2000-05-26 Horiba Ltd アンモニウムイオン測定装置
DE69919224T2 (de) * 1999-03-19 2005-07-28 Sapporo Immuno Diagnostic Laboratory, Sapporo Verfahren zur bestimmung eines substrates, und biosensor
US6662439B1 (en) 1999-10-04 2003-12-16 Roche Diagnostics Corporation Laser defined features for patterned laminates and electrodes
US6645359B1 (en) 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
WO2003005890A2 (en) * 2001-07-09 2003-01-23 Arizona Board Of Regents A Body Corporate Acting On Behalf Of Arizona State University Affinity biosensor for monitoring of biological process
US7150975B2 (en) 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
US9101302B2 (en) 2004-05-03 2015-08-11 Abbott Diabetes Care Inc. Analyte test device
JP2006126092A (ja) * 2004-10-29 2006-05-18 Ntt Advanced Technology Corp 薄層流路および透析膜を有する微小バイオセンサ
US8409864B2 (en) * 2006-01-06 2013-04-02 Renal Solutions, Inc. Ammonia sensor and system for use
US20090294302A1 (en) * 2008-05-28 2009-12-03 John Pasqua Use of Alginate to Reduce Hematocrit Bias in Biosensors
JP2010160134A (ja) * 2008-12-11 2010-07-22 Unitika Ltd 検知材および定量方法
JP2014010145A (ja) 2012-07-02 2014-01-20 Aquatech Co Ltd 液中アンモニアを検知し、反応を制御する装置

Also Published As

Publication number Publication date
DK3540429T3 (da) 2021-02-15
SA516370640B1 (ar) 2019-02-24
DK3039422T3 (en) 2019-03-25
US20160231310A1 (en) 2016-08-11
JP6646579B2 (ja) 2020-02-14
US10620187B2 (en) 2020-04-14
CN105940300A (zh) 2016-09-14
EP3039422A4 (en) 2017-04-19
IL244274A0 (en) 2016-04-21
EP3039422A1 (en) 2016-07-06
CA2922821A1 (en) 2015-03-05
CN105940300B (zh) 2019-01-22
WO2015031911A1 (en) 2015-03-05
CA2922821C (en) 2023-01-03
EP3540429B1 (en) 2020-11-11
BR112016004320A2 (pt) 2017-10-24
AU2014311977B2 (en) 2019-02-21
US9952199B2 (en) 2018-04-24
BR112016004320B1 (pt) 2022-03-03
IL244274B (en) 2020-09-30
US20180284099A1 (en) 2018-10-04
CL2016000467A1 (es) 2016-10-28
AU2014311977A1 (en) 2016-03-17
KR20160048204A (ko) 2016-05-03
JP2016529515A (ja) 2016-09-23
EP3039422B1 (en) 2019-01-09
KR102278346B1 (ko) 2021-07-19
EP3540429A1 (en) 2019-09-18
MX2016002632A (es) 2016-10-04

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