TR201811308T4 - Kanser kok hücrelerini azaltan anti-emp2 tedavisi. - Google Patents
Kanser kok hücrelerini azaltan anti-emp2 tedavisi. Download PDFInfo
- Publication number
- TR201811308T4 TR201811308T4 TR2018/11308T TR201811308T TR201811308T4 TR 201811308 T4 TR201811308 T4 TR 201811308T4 TR 2018/11308 T TR2018/11308 T TR 2018/11308T TR 201811308 T TR201811308 T TR 201811308T TR 201811308 T4 TR201811308 T4 TR 201811308T4
- Authority
- TR
- Turkey
- Prior art keywords
- emp2
- reduces cancer
- stem cells
- cancer
- coke
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 4
- 239000000571 coke Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 abstract 3
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 102100032912 CD44 antigen Human genes 0.000 abstract 1
- 102100033176 Epithelial membrane protein 2 Human genes 0.000 abstract 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 abstract 1
- 101000851002 Homo sapiens Epithelial membrane protein 2 Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07K2317/626—Diabody or triabody
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Abstract
EMP2 ekspresyonunun ve / veya anti-EMP2 tedavisinin azaltılması, kanser kök hücrelerinin çoklu kanser türlerinde azalmasına neden olur. Örneğin, göğüs kanserleri kök hücreleri HIF-lafa, CD44 ve ALDH varlığında tanımlanmıştır. Anti-EMP2 IgG1'inin kanser kök hücrelerinin sayısını azaltmak için kullanılabileceği bulunmuştur.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261617996P | 2012-03-30 | 2012-03-30 |
Publications (1)
Publication Number | Publication Date |
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TR201811308T4 true TR201811308T4 (tr) | 2018-08-27 |
Family
ID=49261054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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TR2018/11308T TR201811308T4 (tr) | 2012-03-30 | 2013-03-14 | Kanser kok hücrelerini azaltan anti-emp2 tedavisi. |
Country Status (12)
Country | Link |
---|---|
US (2) | US20150329621A1 (tr) |
EP (1) | EP2831110B1 (tr) |
JP (1) | JP2015514708A (tr) |
AU (1) | AU2013203396C1 (tr) |
CA (1) | CA2868791A1 (tr) |
DK (1) | DK2831110T3 (tr) |
ES (1) | ES2689269T3 (tr) |
HU (1) | HUE039389T2 (tr) |
PL (1) | PL2831110T3 (tr) |
PT (1) | PT2831110T (tr) |
TR (1) | TR201811308T4 (tr) |
WO (1) | WO2013148263A1 (tr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013155346A1 (en) | 2012-04-11 | 2013-10-17 | The Regents Of The University Of California | Diagnostic tools for response to 6-thiopurine therapy |
LT3027651T (lt) * | 2013-08-01 | 2019-04-10 | Five Prime Therapeutics, Inc. | Afukozilinti anti-fgfr2iiib antikūnai |
TWI791422B (zh) | 2015-11-23 | 2023-02-11 | 美商戊瑞治療有限公司 | 用於癌症治療之單獨fgfr2抑制劑或與免疫刺激劑組合 |
CA3009644A1 (en) * | 2015-12-04 | 2017-06-08 | The Regents Of The University Of California | Novel antibodies for the treatment of cancers |
US20190352399A1 (en) * | 2017-01-20 | 2019-11-21 | The Regents Of The University Of California | Treatment of cancers using anti-emp2 antibody and pd-1/pdl-1 pathway antagonist combination therapy |
US20210164984A1 (en) * | 2018-04-13 | 2021-06-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting outcome and treatment of patients suffering from prostate cancer or breast cancer |
CN112118867A (zh) * | 2018-04-30 | 2020-12-22 | 美国卫生与公众服务部长代表部门 | 上皮膜蛋白2靶向剂在治疗肺疾病中的应用 |
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AU735884B2 (en) * | 1996-04-26 | 2001-07-19 | Magainin Pharmaceuticals, Inc. | Treatment of carcinomas using squalamine in combination with other anti-cancer agents |
EP1868599B1 (en) * | 2005-04-08 | 2009-11-11 | NERVIANO MEDICAL SCIENCES S.r.l. | Antitumor combination comprising substituted acryloyl distamycin derivatives and antibodies inhibiting growth factors or their receptors |
US8648052B2 (en) | 2005-04-15 | 2014-02-11 | The Regents Of The University Of California | Prevention of chlamydia infection using SIRNA |
US8318906B2 (en) * | 2005-04-15 | 2012-11-27 | The Regents Of The University Of California | EMP2 antibodies and their therapeutic uses |
US20090123439A1 (en) * | 2007-11-09 | 2009-05-14 | The Jackson Laboratory | Diagnostic and prognosis methods for cancer stem cells |
EP2766045B1 (en) * | 2011-10-13 | 2016-12-07 | The Regents of The University of California | Treatment of breast cancer with companion diagnostic |
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US20190077852A1 (en) | 2019-03-14 |
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AU2013203396A1 (en) | 2013-10-17 |
JP2015514708A (ja) | 2015-05-21 |
HUE039389T2 (hu) | 2019-01-28 |
EP2831110A4 (en) | 2016-01-06 |
US20150329621A1 (en) | 2015-11-19 |
AU2013203396C1 (en) | 2016-06-09 |
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