PT2831110T - Terapia anti-emp2 reduz as células-tronco do cancro - Google Patents

Terapia anti-emp2 reduz as células-tronco do cancro

Info

Publication number
PT2831110T
PT2831110T PT137703104T PT13770310T PT2831110T PT 2831110 T PT2831110 T PT 2831110T PT 137703104 T PT137703104 T PT 137703104T PT 13770310 T PT13770310 T PT 13770310T PT 2831110 T PT2831110 T PT 2831110T
Authority
PT
Portugal
Prior art keywords
stem cells
cancer stem
therapy reduces
reduces cancer
emp2 therapy
Prior art date
Application number
PT137703104T
Other languages
English (en)
Inventor
Braun Jonathan
K Gordon Lynn
Wadehra Madhuri
S Lazar Gary
Original Assignee
Univ California
Paganini Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Paganini Biopharma Inc filed Critical Univ California
Publication of PT2831110T publication Critical patent/PT2831110T/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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PT137703104T 2012-03-30 2013-03-14 Terapia anti-emp2 reduz as células-tronco do cancro PT2831110T (pt)

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US (2) US20150329621A1 (pt)
EP (1) EP2831110B1 (pt)
JP (1) JP2015514708A (pt)
AU (1) AU2013203396C1 (pt)
CA (1) CA2868791A1 (pt)
DK (1) DK2831110T3 (pt)
ES (1) ES2689269T3 (pt)
HU (1) HUE039389T2 (pt)
PL (1) PL2831110T3 (pt)
PT (1) PT2831110T (pt)
TR (1) TR201811308T4 (pt)
WO (1) WO2013148263A1 (pt)

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WO2013155346A1 (en) 2012-04-11 2013-10-17 The Regents Of The University Of California Diagnostic tools for response to 6-thiopurine therapy
NZ715201A (en) * 2013-08-01 2021-12-24 Five Prime Therapeutics Inc Afucosylated anti-fgfr2iiib antibodies
BR112018010410A8 (pt) 2015-11-23 2019-02-26 Five Prime Therapeutics Inc método para tratar câncer em um sujeito, composição e métodos de aumento do número de células nk e de aumento do número de uma ou mais células positivas para pd-l1
BR112018011270A2 (pt) * 2015-12-04 2018-11-21 Univ California anticorpo isolado, composição farmacêutica, e, métodos para tratamento ou redução da taxa de recorrência de um câncer em um paciente e para detecção de células tronco do câncer.
WO2018136891A1 (en) * 2017-01-20 2018-07-26 The Regents Of The University Of California Treatment of cancers using anti-emp2 antibody and pd-1/pdl-1 pathway antagonist combination therapy
JP2021521445A (ja) * 2018-04-13 2021-08-26 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 前立腺癌又は乳癌を患っている患者の転帰を予測するための及び処置のための方法
EP3787682B1 (en) * 2018-04-30 2024-03-06 The USA, as represented by The Secretary, Department of Health and Human Services Use of epithelial membrane protein 2 (emp2) targeting agents in treating lung disorders

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JP2000510460A (ja) * 1996-04-26 2000-08-15 マゲイニン・ファーマシューティカルズ・インコーポレーテッド スクアラミンを他の抗癌剤と併用する上皮性悪性腫瘍の治療
ES2335805T3 (es) * 2005-04-08 2010-04-05 Nerviano Medical Sciences S.R.L. Combinacion antitumoral que comprende derivados de acriloil distamicina sustituidos y anticuerpos inhibidores de factores de crecimiento o de sus receptores.
US8648052B2 (en) * 2005-04-15 2014-02-11 The Regents Of The University Of California Prevention of chlamydia infection using SIRNA
US8318906B2 (en) * 2005-04-15 2012-11-27 The Regents Of The University Of California EMP2 antibodies and their therapeutic uses
US20090123439A1 (en) * 2007-11-09 2009-05-14 The Jackson Laboratory Diagnostic and prognosis methods for cancer stem cells
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AU2013203396A1 (en) 2013-10-17
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US20190077852A1 (en) 2019-03-14
JP2015514708A (ja) 2015-05-21
EP2831110B1 (en) 2018-05-09
EP2831110A1 (en) 2015-02-04
AU2013203396C1 (en) 2016-06-09
US20150329621A1 (en) 2015-11-19
PL2831110T3 (pl) 2018-11-30
ES2689269T3 (es) 2018-11-13
AU2013203396B2 (en) 2016-01-14
DK2831110T3 (en) 2018-08-06
HUE039389T2 (hu) 2019-01-28
CA2868791A1 (en) 2013-10-03

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