TR200401980T4 - Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonu - Google Patents
Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonuInfo
- Publication number
- TR200401980T4 TR200401980T4 TR2004/01980T TR200401980T TR200401980T4 TR 200401980 T4 TR200401980 T4 TR 200401980T4 TR 2004/01980 T TR2004/01980 T TR 2004/01980T TR 200401980 T TR200401980 T TR 200401980T TR 200401980 T4 TR200401980 T4 TR 200401980T4
- Authority
- TR
- Turkey
- Prior art keywords
- aerosol administration
- tobramycin formulation
- optimized
- formulation optimized
- tobramycin
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000000443 aerosol Substances 0.000 title abstract 2
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 title abstract 2
- 229960000707 tobramycin Drugs 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 201000003883 Cystic fibrosis Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000000644 isotonic solution Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
Bulus pH'si oda sicakliginda yeterli raf ömrü saglamak için en uygun hale getirilmis, katki maddesiz, izotonik solüsyon biçiminde aerosol olarak uygulama için bir tobramisin formülasyonu sunmaktadir. Adi geçen formülasyon avantajli bir sekilde akut ve kronik endobronkiyal enfeksiyonlarin, özellikle kistik fibroz gibi akciger hastaliklariyla iliskili Pseudomonas aeruginosa bakterisinin neden oldugu enfeksiyonlarin tedavisi ve profilaksisinde kullanilabilir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01116071A EP1273292B1 (en) | 2001-07-02 | 2001-07-02 | Optimised formulation of tobramycin for aerosolization |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200401980T4 true TR200401980T4 (tr) | 2004-09-21 |
Family
ID=8177921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/01980T TR200401980T4 (tr) | 2001-07-02 | 2001-07-02 | Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonu |
Country Status (27)
Country | Link |
---|---|
US (5) | US6987094B2 (tr) |
EP (1) | EP1273292B1 (tr) |
JP (1) | JP4262086B2 (tr) |
KR (1) | KR100910888B1 (tr) |
CN (1) | CN1234346C (tr) |
AT (1) | ATE267591T1 (tr) |
AU (1) | AU2002319226B2 (tr) |
BG (1) | BG66328B1 (tr) |
BR (1) | BRPI0211320B8 (tr) |
CA (1) | CA2452638C (tr) |
CZ (1) | CZ299348B6 (tr) |
DE (1) | DE60103527T2 (tr) |
DK (1) | DK1273292T3 (tr) |
EA (1) | EA006068B1 (tr) |
EE (1) | EE05392B1 (tr) |
EG (1) | EG24019A (tr) |
ES (1) | ES2222294T3 (tr) |
HK (1) | HK1068784A1 (tr) |
HU (1) | HU230807B1 (tr) |
PL (1) | PL202598B1 (tr) |
PT (1) | PT1273292E (tr) |
SI (1) | SI1273292T1 (tr) |
SK (1) | SK285806B6 (tr) |
TN (1) | TNSN03149A1 (tr) |
TR (1) | TR200401980T4 (tr) |
WO (1) | WO2003004005A1 (tr) |
ZA (1) | ZA200400026B (tr) |
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TW465235B (en) | 1998-09-17 | 2001-11-21 | United Video Properties Inc | Electronic program guide with digital storage |
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PT1273292E (pt) * | 2001-07-02 | 2004-10-29 | Chiesi Farma Spa | Formulacao optimizada de tobramicina para aerossolizacao |
WO2003053411A1 (en) | 2001-12-19 | 2003-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
PT3384931T (pt) * | 2002-03-01 | 2019-09-26 | Chiesi Farm Spa | Formulaçâo superfina de formoterol |
RU2341267C2 (ru) * | 2003-10-15 | 2008-12-20 | Пари Фарма Гмбх | Жидкий препарат, содержащий тобрамицин |
US8442280B2 (en) * | 2004-01-21 | 2013-05-14 | Edda Technology, Inc. | Method and system for intelligent qualitative and quantitative analysis of digital radiography softcopy reading |
DK2316419T3 (da) | 2004-05-17 | 2012-10-22 | Gilead Sciences Inc | Kombination af fosfomycin/tobramycin-aerosolform til behandling af bakterielle luftvejsinfektioner |
US8524734B2 (en) * | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US7838532B2 (en) * | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
CA2622193A1 (en) * | 2005-09-29 | 2007-04-12 | Nektar Therapeutics | Antibiotic formulations, unit doses, kits, and methods |
US20090246146A1 (en) * | 2008-01-25 | 2009-10-01 | Botond Banfi | Halides in the treatment of pathogenic infection |
PT2344129T (pt) * | 2008-10-07 | 2018-04-23 | Horizon Orphan Llc | Formulações de fluoroquinolona em aerossol para farmacocinética melhorada |
CN102325532B (zh) * | 2008-10-07 | 2015-06-17 | Mpex医药有限公司 | 用于减轻肺部炎症的左氧氟沙星吸入剂 |
WO2010096242A1 (en) * | 2009-02-18 | 2010-08-26 | Aradigm Corporation | Ph-modulated formulations for pulmonary delivery |
IN2012DN02477A (tr) | 2009-09-04 | 2015-08-21 | Mpex Pharmaceuticals Inc | |
EP2388008A1 (en) | 2010-05-14 | 2011-11-23 | Combino Pharm, S.L. | Stable, preservative-free, aqueous formulation for the administration by aerosolization comprising tobramycin |
CN106074461A (zh) | 2010-07-12 | 2016-11-09 | 赛利亚医药公司 | 通过氨基糖苷气雾给药治疗肺部感染 |
WO2012034955A1 (en) * | 2010-09-13 | 2012-03-22 | University Of Zurich | Treatment of bacterial infectious diseases |
EP4059499A1 (en) | 2011-01-31 | 2022-09-21 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
EP2567691B1 (en) | 2011-09-12 | 2014-12-24 | Meiji Seika Pharma Co., Ltd. | Aqueous compositions comprising arbekacin |
GB201208080D0 (en) | 2012-05-09 | 2012-06-20 | Norton Healthcare Ltd | Tobramycin formulation |
CN105534961B (zh) * | 2015-12-30 | 2019-06-04 | 孙红娟 | 妥布霉素吸入溶液及其制备方法 |
CN105616345B (zh) * | 2016-03-01 | 2018-08-21 | 上海方予健康医药科技有限公司 | 一种妥布霉素吸入组合物及其制备方法和用途 |
WO2018107020A1 (en) * | 2016-12-09 | 2018-06-14 | Enbiotix, Inc. | Aminoglycoside potentiation for treatment of pulmonary bacterial infection |
CN108014099B (zh) * | 2017-12-15 | 2019-03-01 | 武汉兴华智慧医药科技有限公司 | 一种吸入用妥布霉素溶液及其制备方法 |
GB2565941A (en) * | 2018-11-27 | 2019-02-27 | Norton Healthcare Ltd | A process for preparing a formulation |
CN113018443B (zh) * | 2019-12-27 | 2022-09-13 | 海南斯达制药有限公司 | 治疗呼吸***疾病的药物组合物及其制备方法 |
CN113952320B (zh) * | 2021-09-18 | 2022-03-18 | 健康元药业集团股份有限公司 | 一种包含妥布霉素吸入溶液的药物组件及其用途 |
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-
2001
- 2001-07-02 PT PT01116071T patent/PT1273292E/pt unknown
- 2001-07-02 ES ES01116071T patent/ES2222294T3/es not_active Expired - Lifetime
- 2001-07-02 EP EP01116071A patent/EP1273292B1/en not_active Expired - Lifetime
- 2001-07-02 DK DK01116071T patent/DK1273292T3/da active
- 2001-07-02 SI SI200130154T patent/SI1273292T1/xx unknown
- 2001-07-02 AT AT01116071T patent/ATE267591T1/de active
- 2001-07-02 DE DE60103527T patent/DE60103527T2/de not_active Expired - Lifetime
- 2001-07-02 TR TR2004/01980T patent/TR200401980T4/tr unknown
-
2002
- 2002-06-14 US US10/482,224 patent/US6987094B2/en not_active Expired - Lifetime
- 2002-06-14 BR BRPI0211320A patent/BRPI0211320B8/pt not_active IP Right Cessation
- 2002-06-14 AU AU2002319226A patent/AU2002319226B2/en not_active Expired
- 2002-06-14 WO PCT/EP2002/006544 patent/WO2003004005A1/en active Application Filing
- 2002-06-14 CA CA2452638A patent/CA2452638C/en not_active Expired - Lifetime
- 2002-06-14 CZ CZ20033580A patent/CZ299348B6/cs not_active IP Right Cessation
- 2002-06-14 HU HU0400387A patent/HU230807B1/hu unknown
- 2002-06-14 EE EEP200400050A patent/EE05392B1/xx unknown
- 2002-06-14 CN CNB028143140A patent/CN1234346C/zh not_active Expired - Lifetime
- 2002-06-14 KR KR1020037017141A patent/KR100910888B1/ko active IP Right Grant
- 2002-06-14 PL PL367139A patent/PL202598B1/pl unknown
- 2002-06-14 EA EA200301305A patent/EA006068B1/ru active Protection Beyond IP Right Term
- 2002-06-14 SK SK1643-2003A patent/SK285806B6/sk not_active IP Right Cessation
- 2002-06-14 JP JP2003510016A patent/JP4262086B2/ja not_active Expired - Lifetime
- 2002-06-29 EG EG2002060744A patent/EG24019A/xx active
-
2003
- 2003-07-08 TN TNPCT/EP2002/006544A patent/TNSN03149A1/en unknown
- 2003-12-19 BG BG108475A patent/BG66328B1/bg unknown
-
2004
- 2004-01-05 ZA ZA2004/00026A patent/ZA200400026B/en unknown
-
2005
- 2005-02-03 HK HK05100912A patent/HK1068784A1/xx not_active IP Right Cessation
- 2005-03-18 US US11/083,139 patent/US7696178B2/en not_active Expired - Lifetime
-
2009
- 2009-12-18 US US12/642,336 patent/US7939502B2/en not_active Expired - Fee Related
-
2011
- 2011-05-06 US US13/102,378 patent/US8168598B2/en not_active Expired - Lifetime
-
2012
- 2012-03-26 US US13/429,624 patent/US20120184502A1/en not_active Abandoned
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