TR200201168T2 - CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri. - Google Patents

CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri.

Info

Publication number
TR200201168T2
TR200201168T2 TR2002/01168T TR200201168T TR200201168T2 TR 200201168 T2 TR200201168 T2 TR 200201168T2 TR 2002/01168 T TR2002/01168 T TR 2002/01168T TR 200201168 T TR200201168 T TR 200201168T TR 200201168 T2 TR200201168 T2 TR 200201168T2
Authority
TR
Turkey
Prior art keywords
cgrp
cyclopropanes
antagonists
production methods
drugs containing
Prior art date
Application number
TR2002/01168T
Other languages
English (en)
Inventor
Eberlein Wolfgang
Engel Wolfhard
Rudolf Klaus
Doods Henri
Hallermayer Gerhard
Bauer Eckhart
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of TR200201168T2 publication Critical patent/TR200201168T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Elde bulunan bulus, genel formül (I)'in bilesiklerini kapsamaktadir, bunun içerisinde R ve R istem 1'deki gibi açiklanmistir ve bunlarin tautomerleri, bunlarin diastereomerleri, bunlarin enantiyomerleri, bunlarin karisimlari ve bunlarin tuzlari, özellikle bunlarin fizyolojik açidan tolere edilebilen tuzlari, degerli farmakolojik özelliklere, özellikle CGRP-antagonistik özelliklere sahip olan anorganik veya organik asitler ve bazlari ile bu bilesikleri içeren ilaçlar, bunlarin kullanim sekli ve üretiminde gidilen yöntemleri kapsamaktadir. formül (1)
TR2002/01168T 1999-10-29 2000-10-21 CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri. TR200201168T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19952147A DE19952147A1 (de) 1999-10-29 1999-10-29 Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
TR200201168T2 true TR200201168T2 (tr) 2002-08-21

Family

ID=7927315

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01168T TR200201168T2 (tr) 1999-10-29 2000-10-21 CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri.

Country Status (27)

Country Link
US (2) US20030139417A1 (tr)
EP (1) EP1228059B1 (tr)
JP (1) JP3869721B2 (tr)
KR (1) KR20020047290A (tr)
CN (1) CN1177844C (tr)
AT (1) ATE301117T1 (tr)
AU (1) AU781856B2 (tr)
BG (1) BG106638A (tr)
BR (1) BR0015147A (tr)
CA (1) CA2387134C (tr)
CZ (1) CZ20021812A3 (tr)
DE (2) DE19952147A1 (tr)
EA (1) EA005137B1 (tr)
EE (1) EE200200220A (tr)
HK (1) HK1051858A1 (tr)
HR (1) HRP20020373A2 (tr)
HU (1) HUP0203496A3 (tr)
IL (1) IL148975A0 (tr)
MX (1) MXPA02004119A (tr)
NO (1) NO20021799L (tr)
NZ (1) NZ518698A (tr)
PL (1) PL354715A1 (tr)
SK (1) SK7282002A3 (tr)
TR (1) TR200201168T2 (tr)
WO (1) WO2001032648A1 (tr)
YU (1) YU30902A (tr)
ZA (1) ZA200203256B (tr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7842808B2 (en) 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
AU2003237255B8 (en) * 2002-06-05 2010-01-07 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
AR046787A1 (es) 2003-12-05 2005-12-21 Bristol Myers Squibb Co Agentes antimigrana heterociclicos
BR0318637A (pt) 2003-12-05 2007-02-13 Bristol Myers Squibb Co antagonistas de receptores de peptìdios relacionados com o gene de calcitonina
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
JP2008512459A (ja) * 2004-09-09 2008-04-24 メルク エンド カムパニー インコーポレーテッド アリールスピロラクタムｃｇｒｐ受容体拮抗薬
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
US7834007B2 (en) 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
WO2007061677A2 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam aryl cgrp receptor antagonists
WO2009034029A2 (de) * 2007-09-07 2009-03-19 Boehringer Ingelheim International Gmbh 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten
EP2065381A1 (de) 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP Antagonisten
MX2010003849A (es) 2007-10-18 2010-04-27 Boehringer Ingelheim Int Antagonistas de cgrp.
EP2225223B1 (de) 2007-11-22 2017-01-11 Boehringer Ingelheim International GmbH Organische verbindungen
US9315449B2 (en) 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EA201491606A1 (ru) * 2012-04-05 2015-03-31 Схди Фаундейшн, Инк. Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения
US9938252B2 (en) 2013-09-26 2018-04-10 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9884853B2 (en) 2013-09-26 2018-02-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP2019040859A (ja) * 2017-08-22 2019-03-14 株式会社エンプラス 発光装置、面光源装置および光束制御部材
CN114957145B (zh) * 2022-04-14 2023-07-18 浙江师范大学 一种1,2,4-苯并三嗪衍生物及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655667A (en) * 1968-04-04 1972-04-11 Smith Kline French Lab 1-(2-benzoylcyclopropylmethyl)-4-phenylpiperazines
US3873707A (en) * 1972-10-02 1975-03-25 Robins Co Inc A H 1-Cyclopropyl-3-mono-(and 2,3-di) substituted-1-propanones in compositions and method for treating pain
FR2729855A1 (fr) 1995-01-26 1996-08-02 Oreal Utilisation d'un antagoniste de cgrp dans une composition cosmetique, pharmaceutique ou dermatologique et composition obtenue
IL124557A0 (en) 1995-12-15 1998-12-06 Novo Nordisk As Compositions for reducing blood glucose and/or inhibiting the activity of cgrp
JP2002511836A (ja) * 1996-09-09 2002-04-16 スミスクライン・ビーチャム・コーポレイション 化合物および方法
EE04375B1 (et) * 1996-09-10 2004-10-15 Dr. Karl Thomae Gmbh Modifitseeritud aminohapped, neid ühendeid sisaldavad ravimid ja nende valmistamise meetod
CA2291115A1 (en) 1997-05-22 1998-11-26 G.D. Searle & Co. Substituted pyrazoles as p38 kinase inhibitors
AU2825999A (en) * 1998-03-17 1999-10-11 Novo Nordisk A/S Novel heterocyclic compounds
DE19911039A1 (de) 1999-03-12 2000-09-14 Boehringer Ingelheim Pharma Abgewandelte Aminosäureamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
KR20010108394A (ko) * 1999-03-26 2001-12-07 다비드 에 질레스 신규 화합물
DE19937304C2 (de) 1999-08-10 2003-08-21 Boehringer Ingelheim Pharma Verwendung von CGRP-Antagonisten zur Bekämpfung menopausaler Hitzewallungen
US6696418B1 (en) * 1999-09-01 2004-02-24 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
TWI227231B (en) * 2000-07-12 2005-02-01 Novartis Ag 4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3
AU2002223968A1 (en) * 2000-12-21 2002-07-01 Warner Lambert Company Llc Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists
JP2005511560A (ja) * 2001-11-01 2005-04-28 バーテックス ファーマシューティカルズ インコーポレイテッド コレステロール生合成経路の変調
US6977265B2 (en) * 2001-11-30 2005-12-20 Roche Palo Alto Llc Piperidine CCR-3 receptor antagonists
US7026312B2 (en) * 2002-03-14 2006-04-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof

Also Published As

Publication number Publication date
AU7921300A (en) 2001-05-14
DE19952147A1 (de) 2001-05-03
DE50010886D1 (de) 2005-09-08
YU30902A (sh) 2005-07-19
AU781856B2 (en) 2005-06-16
BG106638A (bg) 2003-01-31
EE200200220A (et) 2003-06-16
NZ518698A (en) 2004-12-24
MXPA02004119A (es) 2003-10-06
CA2387134A1 (en) 2001-05-10
JP3869721B2 (ja) 2007-01-17
WO2001032648A1 (de) 2001-05-10
HK1051858A1 (en) 2003-08-22
JP2003513087A (ja) 2003-04-08
PL354715A1 (en) 2004-02-09
HRP20020373A2 (en) 2003-10-31
US7407963B2 (en) 2008-08-05
US20050267137A1 (en) 2005-12-01
US20030139417A1 (en) 2003-07-24
NO20021799D0 (no) 2002-04-17
BR0015147A (pt) 2002-07-16
NO20021799L (no) 2002-04-17
HUP0203496A2 (hu) 2003-02-28
EA005137B1 (ru) 2004-12-30
IL148975A0 (en) 2002-11-10
CZ20021812A3 (cs) 2002-08-14
CN1387526A (zh) 2002-12-25
HUP0203496A3 (en) 2004-01-28
CN1177844C (zh) 2004-12-01
EP1228059B1 (de) 2005-08-03
KR20020047290A (ko) 2002-06-21
SK7282002A3 (en) 2002-11-06
CA2387134C (en) 2008-07-08
EP1228059A1 (de) 2002-08-07
EA200200447A1 (ru) 2002-10-31
ZA200203256B (en) 2003-04-10
ATE301117T1 (de) 2005-08-15

Similar Documents

Publication Publication Date Title
TR200201168T2 (tr) CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri.
NO941677D0 (no) Tetrazolderivater av gallesyrer, fremgangsmåter for fremstilling og deres anvendelse som legemiddel
NO20015226L (no) Tri-aryl syrederivater som PPAR reseptor ligander, farmasoytisk sammensetning omfattende samme og anvendelse av samme for fremstilling av medikament.
TR199801749T2 (tr) 4-Amino-pirimidin-türevleri ve bunlari içeren ilaçlar
DE69627035T2 (de) Derivate von aminosäuren, sie enthaltende pharmazeutische zusammensetzungen sowie deren herstellunsgverfahren
RS50140B (sr) Postupak za dobijanje perkihinina i njegova upotreba
NO20021229D0 (no) Benzamider og lignende inhibitorer for faktor Xa
ATE296826T1 (de) Pyrazolo(1,5)pyridinderivate
TR199900920T2 (tr) Nafthiridin türevleri.
IS6257A (is) Frumuviðloðunartálmar
DK1272477T3 (da) Pyrimidinforbindelser
DK0944643T3 (da) Oxyiminopregnancarbolactoner.
TR200102910T2 (tr) èeker artìklarìyla ikame edilmiç 1,4-benzotiyazepin-1,1-dioksid trevleri
YU50002A (sh) Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju
BR0007589A (pt) Inibidores da proliferação de células
CY1107149T1 (el) Νεα παραγωγα αμιδινοβενζυλαμινης και χρηση τους ως αναστολεων θρομβινης
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
NO20001483L (no) Nye NPY-agonister
DE69813565D1 (de) Substituierte 3,3-diamino-2-propennitrile, ihre herstellung und verwendung
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
MXPA02004441A (es) Derivados de isoxazol como inhibidores de la fosfodiesterasa.
ATE219085T1 (de) 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren
HRP20010885B1 (en) Ethanesulfonyl-piperidine derivatives
TR200200017T2 (tr) Benzofuran türevleri
TR200100182T2 (tr) Antitrombotik etkili ikame edilmiş fenilamidinler