TR200103398T2 - íkameli fenilsikloheksankarboksamitler ve bunlarìn adenozin alìnìmìnìn inhibit”rleri olarak kullanìmì - Google Patents

íkameli fenilsikloheksankarboksamitler ve bunlarìn adenozin alìnìmìnìn inhibit”rleri olarak kullanìmì

Info

Publication number
TR200103398T2
TR200103398T2 TR2001/03398T TR200103398T TR200103398T2 TR 200103398 T2 TR200103398 T2 TR 200103398T2 TR 2001/03398 T TR2001/03398 T TR 2001/03398T TR 200103398 T TR200103398 T TR 200103398T TR 200103398 T2 TR200103398 T2 TR 200103398T2
Authority
TR
Turkey
Prior art keywords
adenosine
inhibitors
intake
phenylcyclohexanecarboxamides
substituted
Prior art date
Application number
TR2001/03398T
Other languages
English (en)
Inventor
Bischoff Erwin
Lensky Stephan
Muller Stephan-Nicholas
Paulsen Holger
Keldenich Jorg
Krahn Thomas
Schuhmacher Joachim
Janichen Jan
Thielemann Wolfgang
Steinhagen Henning
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of TR200103398T2 publication Critical patent/TR200103398T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Bu buluç fomül (I) ikameli fenilsikloheksankarboksamitlerine, bunlar haz rlamak için içlemlere ve bunlar n ilaçlarda, özellikle kalp-damar bozukluklar n n tedavisine yönelik ilaçlarda kullan m na iliçkindir.
TR2001/03398T 1999-05-29 2000-05-16 íkameli fenilsikloheksankarboksamitler ve bunlarìn adenozin alìnìmìnìn inhibit”rleri olarak kullanìmì TR200103398T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19924819A DE19924819A1 (de) 1999-05-29 1999-05-29 Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)

Publications (1)

Publication Number Publication Date
TR200103398T2 true TR200103398T2 (tr) 2002-03-21

Family

ID=7909713

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03398T TR200103398T2 (tr) 1999-05-29 2000-05-16 íkameli fenilsikloheksankarboksamitler ve bunlarìn adenozin alìnìmìnìn inhibit”rleri olarak kullanìmì

Country Status (25)

Country Link
US (1) US6984642B1 (tr)
EP (1) EP1187812B1 (tr)
JP (1) JP2003500474A (tr)
KR (1) KR20020000814A (tr)
CN (1) CN1165526C (tr)
AR (1) AR029639A1 (tr)
AT (1) ATE303995T1 (tr)
AU (1) AU766140B2 (tr)
BR (1) BR0011049A (tr)
CA (1) CA2375188A1 (tr)
CO (1) CO5170503A1 (tr)
DE (2) DE19924819A1 (tr)
DK (1) DK1187812T3 (tr)
ES (1) ES2248071T3 (tr)
GT (1) GT200000085A (tr)
HK (1) HK1047107B (tr)
HN (1) HN2000000078A (tr)
IL (1) IL146231A0 (tr)
MX (1) MXPA01012240A (tr)
PE (1) PE20010132A1 (tr)
PL (1) PL365960A1 (tr)
TR (1) TR200103398T2 (tr)
UY (1) UY26179A1 (tr)
WO (1) WO2000073274A2 (tr)
ZA (1) ZA200108894B (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10150310A1 (de) * 2001-10-11 2003-04-24 Bayer Ag Substituierte Piperazincyclohexancarbonsäureamide und ihre Verwendung
KR100762857B1 (ko) * 2005-03-07 2007-10-02 김기완 Ｐｅ시트를 이용한 저수조의 방수 공법
KR100762858B1 (ko) * 2005-03-07 2007-10-02 김기완 Ｐｅ시트를 이용한 저수조의 방수 공법
KR100745024B1 (ko) * 2005-05-09 2007-08-01 김준 거푸집 수평조절장치
JP2011528358A (ja) * 2008-07-16 2011-11-17 ブリストル−マイヤーズ スクイブ カンパニー ケモカイン受容体活性のシクロヘキセニルモジュレーター
EP2380595A1 (en) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125285T3 (es) * 1992-07-31 1999-03-01 Bristol Myers Squibb Co Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles.
DE4304455A1 (de) * 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
CN1202159A (zh) * 1995-09-22 1998-12-16 住友化学工业株式会社 吡嗪－2－酮衍生物,它们的应用及用于制备它们的中间体
US5723313A (en) * 1995-09-27 1998-03-03 St. Jude Children's Research Hospital ARF-p19, a novel regulator of the mammalian cell cycle

Also Published As

Publication number Publication date
IL146231A0 (en) 2002-07-25
US6984642B1 (en) 2006-01-10
CA2375188A1 (en) 2000-12-07
AU4405700A (en) 2000-12-18
DK1187812T3 (da) 2005-12-12
EP1187812B1 (de) 2005-09-07
MXPA01012240A (es) 2002-08-12
CN1353693A (zh) 2002-06-12
ZA200108894B (en) 2003-01-29
HK1047107B (zh) 2005-05-20
DE50011122D1 (de) 2005-10-13
EP1187812A2 (de) 2002-03-20
HN2000000078A (es) 2001-02-02
AR029639A1 (es) 2003-07-10
CN1165526C (zh) 2004-09-08
JP2003500474A (ja) 2003-01-07
DE19924819A1 (de) 2000-11-30
BR0011049A (pt) 2002-03-19
WO2000073274A3 (de) 2001-04-19
ES2248071T3 (es) 2006-03-16
ATE303995T1 (de) 2005-09-15
KR20020000814A (ko) 2002-01-05
HK1047107A1 (en) 2003-02-07
UY26179A1 (es) 2000-12-29
WO2000073274A2 (de) 2000-12-07
CO5170503A1 (es) 2002-06-27
GT200000085A (es) 2001-11-17
PL365960A1 (en) 2005-01-24
PE20010132A1 (es) 2001-04-12
AU766140B2 (en) 2003-10-09

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