TR200103095T2 - Renin engelleyiciler. - Google Patents

Renin engelleyiciler.

Info

Publication number
TR200103095T2
TR200103095T2 TR2001/03095T TR200103095T TR200103095T2 TR 200103095 T2 TR200103095 T2 TR 200103095T2 TR 2001/03095 T TR2001/03095 T TR 2001/03095T TR 200103095 T TR200103095 T TR 200103095T TR 200103095 T2 TR200103095 T2 TR 200103095T2
Authority
TR
Turkey
Prior art keywords
renin
blockers
renin blockers
glaucoma
useful
Prior art date
Application number
TR2001/03095T
Other languages
English (en)
Inventor
Breu Volker
Maerki Hans-Peter
Vieira Eric
Wostl Wolfgang
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200103095T2 publication Critical patent/TR200103095T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Bu bulus formül (I)'nin bilesenine ve bunun farmasötik olarak kabul edilebilir tuzlarina dairdir, ki burada R1, R2 ve R3 tarif istemlerde belirtildigi gibidir. Bilesenler restenosis, glaucoma, kalp krizi, yüksek tansiyon ve son organ harabiyeti, ör. kalp yetersizligi ve karaciger eksikligi ile özdeslestirilen hastaliklarin tedavisi için yararlidir.
TR2001/03095T 1999-04-27 2000-04-19 Renin engelleyiciler. TR200103095T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99108199 1999-04-27

Publications (1)

Publication Number Publication Date
TR200103095T2 true TR200103095T2 (tr) 2002-04-22

Family

ID=8238050

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03095T TR200103095T2 (tr) 1999-04-27 2000-04-19 Renin engelleyiciler.

Country Status (35)

Country Link
US (2) US6376672B1 (tr)
EP (1) EP1175400B1 (tr)
JP (1) JP3808706B2 (tr)
KR (1) KR100443684B1 (tr)
CN (1) CN1147471C (tr)
AR (2) AR018719A1 (tr)
AT (1) ATE512949T1 (tr)
AU (1) AU763718B2 (tr)
BR (1) BR0010080B1 (tr)
CA (1) CA2370888C (tr)
CO (1) CO5170513A1 (tr)
CZ (1) CZ302012B6 (tr)
DK (1) DK1175400T3 (tr)
EG (1) EG23979A (tr)
ES (1) ES2366668T3 (tr)
GC (1) GC0000251A (tr)
HK (1) HK1045999B (tr)
HR (1) HRP20010762A2 (tr)
HU (1) HU227764B1 (tr)
IL (2) IL146002A0 (tr)
JO (1) JO2256B1 (tr)
MA (1) MA26787A1 (tr)
MX (1) MXPA01010934A (tr)
MY (1) MY127894A (tr)
NO (1) NO320803B1 (tr)
NZ (1) NZ514981A (tr)
PE (1) PE20010069A1 (tr)
PL (1) PL199895B1 (tr)
PT (1) PT1175400E (tr)
RS (1) RS51156B (tr)
RU (1) RU2213731C2 (tr)
TR (1) TR200103095T2 (tr)
TW (1) TWI224593B (tr)
WO (1) WO2000064873A1 (tr)
ZA (1) ZA200108735B (tr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
US6835686B2 (en) * 2001-07-05 2004-12-28 Millennium Specialty Chemicals Catalyst system and process for rearrangement of epoxides to allylic alcohols
WO2004002957A1 (en) * 2002-06-27 2004-01-08 Actelion Pharmaceuticals Ltd Novel tetrahydropyridine derivatives as renin inhibitors
US20040214832A1 (en) * 2003-04-10 2004-10-28 Cuiman Cai Piperazine derivative renin inhibitors
BRPI0409881A (pt) * 2003-04-29 2006-05-23 Actelion Pharmaceuticals Ltd compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
AR045950A1 (es) * 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
US20050209141A1 (en) * 2003-10-17 2005-09-22 Silver Randi B Mast cell-derived renin
DE602004022704D1 (de) 2003-11-26 2009-10-01 Novartis Ag 4-phenylpiperidinderivate als renininhibitoren
TW200613274A (en) * 2004-07-09 2006-05-01 Speedel Experimenta Ag Organic compounds
KR20070101843A (ko) 2004-10-08 2007-10-17 노파르티스 아게 확장기 기능장애 또는 확장기 심부전의 예방 또는 치료를위한 레닌 억제제의 용도
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
TW200833687A (en) * 2005-03-31 2008-08-16 Speedel Experimenta Ag Substituted piperidines
EP1897879A3 (en) * 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-substituted piperidines as renin inhibitors
WO2006103275A1 (en) * 2005-03-31 2006-10-05 Speedel Experimenta Ag 3,4,5-substituted piperidines as renin inhibitors
EP1707202A1 (de) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organische Verbindungen
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
CN101151262B (zh) * 2005-03-31 2011-07-06 斯皮德尔实验股份公司 取代的哌啶
JP4297972B2 (ja) 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
JP2009512715A (ja) * 2005-10-21 2009-03-26 ノバルティス アクチエンゲゼルシャフト レニン阻害剤と抗異脂肪血症剤および／または抗肥満症剤の組み合わせ
CN101356156B (zh) * 2005-11-14 2012-12-05 生命医药公司 天冬氨酸蛋白酶抑制剂
US8129411B2 (en) * 2005-12-30 2012-03-06 Novartis Ag Organic compounds
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
EP1816122A3 (en) * 2006-01-19 2007-09-19 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
WO2008021552A2 (en) * 2006-08-18 2008-02-21 Duke University Biased ligands and methods of identifying same
EP1908761A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organic compounds
EP1911758A1 (en) * 2006-10-04 2008-04-16 Speedel Experimenta AG Phenyl piperidine derivatives for use as renin inhibitors
ES2541107T3 (es) 2007-06-25 2015-07-16 Novartis Ag Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidindicarboxamida para su uso como inhibidores de renina
EA201000720A1 (ru) * 2007-11-02 2010-10-29 Новартис Аг 4,4-дизамещённые пиперидины как ингибиторы ренина
US10517839B2 (en) 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
AU2010305901A1 (en) 2009-10-14 2012-05-24 Rainer Oberbauer Acute kidney injury risk testing
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
EP2810644A1 (en) 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Oral formulation for the treatment of cardiovascular diseases
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK231088D0 (da) 1988-04-28 1988-04-28 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
DE3640475A1 (de) 1986-11-27 1988-06-09 Hoechst Sa Lab Arzneimittel auf basis von derivaten des 3,4-diphenylpiperidins, die verwendung der derivate als arzneimittel sowie neue 3,4-diphenylpiperidinderivate und verfahren zu ihrer herstellung
ATE137095T1 (de) 1991-06-24 1996-05-15 Optische Ind De Oude Delft Nv Vorrichtung zur beobachtung der atmung
WO1997003911A1 (de) 1995-07-24 1997-02-06 Railfix N.V. Elektro-permanentmagnetsystem zum manövrieren von einer magnetischen insbesondere ferromagnetischen last
CZ292327B6 (cs) 1995-09-07 2003-09-17 F. Hoffmann-La Roche Ag Derivát 4-(oxyalkoxyfenyl)-3-oxypiperidinu, způsob jeho přípravy, meziprodukt pro jeho přípravu a farmaceutický prostředek, který ho obsahuje
AU9740998A (en) * 1997-09-08 1999-03-29 F. Hoffmann-La Roche Ag Piperidine derivatives against malaria
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors

Also Published As

Publication number Publication date
NO20015206L (no) 2001-10-25
HU227764B1 (en) 2012-02-28
TWI224593B (en) 2004-12-01
ZA200108735B (en) 2003-01-23
US20020087002A1 (en) 2002-07-04
MA26787A1 (fr) 2004-12-20
US6376672B1 (en) 2002-04-23
HUP0203669A2 (hu) 2003-02-28
CZ20013854A3 (cs) 2002-04-17
PL199895B1 (pl) 2008-11-28
AU4296800A (en) 2000-11-10
MXPA01010934A (es) 2002-05-06
CZ302012B6 (cs) 2010-09-08
US6673931B2 (en) 2004-01-06
BR0010080A (pt) 2002-01-15
CN1349503A (zh) 2002-05-15
HK1045999B (zh) 2004-10-21
RU2213731C2 (ru) 2003-10-10
HRP20010762A2 (en) 2005-02-28
PL353442A1 (en) 2003-11-17
RS51156B (sr) 2010-10-31
EP1175400A1 (en) 2002-01-30
EG23979A (en) 2008-02-27
EP1175400B1 (en) 2011-06-15
NO20015206D0 (no) 2001-10-25
PE20010069A1 (es) 2001-03-03
CA2370888A1 (en) 2000-11-02
MY127894A (en) 2006-12-29
YU77101A (sh) 2004-09-03
JP2002543063A (ja) 2002-12-17
CA2370888C (en) 2005-08-23
ES2366668T3 (es) 2011-10-24
HUP0203669A3 (en) 2003-12-29
NZ514981A (en) 2004-02-27
JP3808706B2 (ja) 2006-08-16
GC0000251A (en) 2006-11-01
WO2000064873A1 (en) 2000-11-02
ATE512949T1 (de) 2011-07-15
AR018719A1 (es) 2001-11-28
CN1147471C (zh) 2004-04-28
CO5170513A1 (es) 2002-06-27
NO320803B1 (no) 2006-01-30
KR100443684B1 (ko) 2004-08-09
JO2256B1 (en) 2004-10-07
IL146002A (en) 2007-03-08
HK1045999A1 (en) 2002-12-20
AR070473A2 (es) 2010-04-07
KR20010109529A (ko) 2001-12-10
PT1175400E (pt) 2011-08-11
IL146002A0 (en) 2002-07-25
BR0010080B1 (pt) 2012-03-20
DK1175400T3 (da) 2011-07-18
AU763718B2 (en) 2003-07-31

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