TR200002542T2 - Meta-azacyclic amino benzoic acid compounds and their derivatives as integrin antagonists - Google Patents
Meta-azacyclic amino benzoic acid compounds and their derivatives as integrin antagonistsInfo
- Publication number
- TR200002542T2 TR200002542T2 TR2000/02542T TR200002542T TR200002542T2 TR 200002542 T2 TR200002542 T2 TR 200002542T2 TR 2000/02542 T TR2000/02542 T TR 2000/02542T TR 200002542 T TR200002542 T TR 200002542T TR 200002542 T2 TR200002542 T2 TR 200002542T2
- Authority
- TR
- Turkey
- Prior art keywords
- meta
- derivatives
- benzoic acid
- acid compounds
- integrin antagonists
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bu bulus, alfa v 3 integrin antagonistleri olarak yararli olan (I) formülü bilesiklerine ve bu bilesiklerin farmasötik açidan kabul edilebilir tuzlari ve izomerlerine yöneliktir.This invention is directed to the compounds of formula (I) which are useful as alpha v 3 integrin antagonists and their pharmaceutically acceptable salts and isomers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3427098A | 1998-03-04 | 1998-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200002542T2 true TR200002542T2 (en) | 2001-05-21 |
Family
ID=21875345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/02542T TR200002542T2 (en) | 1998-03-04 | 1999-02-22 | Meta-azacyclic amino benzoic acid compounds and their derivatives as integrin antagonists |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1060164A1 (en) |
| JP (1) | JP2002505323A (en) |
| KR (1) | KR20010041584A (en) |
| CN (1) | CN1214011C (en) |
| AP (1) | AP1244A (en) |
| AR (1) | AR018139A1 (en) |
| AU (1) | AU753230B2 (en) |
| BG (1) | BG104740A (en) |
| BR (1) | BR9908470A (en) |
| CA (1) | CA2322207A1 (en) |
| EA (1) | EA200000804A1 (en) |
| EE (1) | EE200000506A (en) |
| GE (1) | GEP20033118B (en) |
| HR (1) | HRP20000574A2 (en) |
| HU (1) | HUP0100865A3 (en) |
| ID (1) | ID25591A (en) |
| IL (1) | IL137653A0 (en) |
| IS (1) | IS5582A (en) |
| MY (1) | MY123908A (en) |
| NO (1) | NO315703B1 (en) |
| NZ (1) | NZ506598A (en) |
| OA (1) | OA11530A (en) |
| PL (1) | PL342726A1 (en) |
| SK (1) | SK13002000A3 (en) |
| TR (1) | TR200002542T2 (en) |
| UA (1) | UA71906C2 (en) |
| WO (1) | WO1999044994A1 (en) |
| YU (1) | YU52000A (en) |
| ZA (1) | ZA994406B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| ATE375330T1 (en) | 2000-04-17 | 2007-10-15 | Ucb Pharma Sa | ENAMINE DERIVATIVES AS CELL ADHESION MOLECULES |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| US6921767B2 (en) * | 2000-06-15 | 2005-07-26 | Pharmacia Corporation | Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives |
| AU2001275724A1 (en) | 2000-08-02 | 2002-02-13 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
| CA2510050A1 (en) * | 2002-12-20 | 2004-07-22 | Pharmacia Corporation | The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| AU2006257815A1 (en) * | 2005-06-10 | 2006-12-21 | Bipar Sciences, Inc. | PARP modulators and treatment of cancer |
| JP2010520238A (en) | 2007-03-01 | 2010-06-10 | マリンクロット インコーポレイテッド | Integrated photoactive small molecule and integrated photoactive small molecule use |
| JP4792124B1 (en) * | 2010-11-15 | 2011-10-12 | エフイートレード株式会社 | Method for molding protective film for vehicle and method for manufacturing protective film for vehicle |
| IN2015DN00099A (en) | 2012-07-18 | 2015-05-29 | Univ Saint Louis | |
| US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| KR20160147007A (en) | 2014-05-30 | 2016-12-21 | 화이자 인코포레이티드 | Carbonitrile derivatives as selective androgen receptor modulators |
| ES2757074T3 (en) * | 2014-06-04 | 2020-04-28 | Monsanto Technology Llc | 3,6-Dichlorosalicylic Acid Compounds and Related Synthetic Procedures |
| CN108779077A (en) | 2015-12-30 | 2018-11-09 | 圣路易斯大学 | Meta position azacyclic amino benzoic acid derivatives as PAN integrin antagonists |
| MX2022014200A (en) | 2020-05-14 | 2022-12-07 | Ube Corp | 1, 4, 5, 6-tetrahydropyrimidine-2-amine derivative. |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2230209A1 (en) * | 1995-08-30 | 1997-03-06 | G.D. Searle & Co. | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists |
-
1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/en unknown
- 1999-02-22 UA UA2000095148A patent/UA71906C2/en unknown
- 1999-02-22 ID IDW20001695A patent/ID25591A/en unknown
- 1999-02-22 YU YU52000A patent/YU52000A/en unknown
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/en unknown
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/en active Pending
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/en unknown
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/en not_active Application Discontinuation
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/en not_active Application Discontinuation
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/en unknown
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 EE EEP200000506A patent/EE200000506A/en unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
- 1999-02-22 IL IL13765399A patent/IL137653A0/en unknown
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/en not_active Application Discontinuation
- 1999-02-22 PL PL99342726A patent/PL342726A1/en unknown
- 1999-02-22 EA EA200000804A patent/EA200000804A1/en unknown
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 EP EP99937927A patent/EP1060164A1/en active Pending
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 CN CNB998035815A patent/CN1214011C/en not_active Expired - Fee Related
- 1999-03-02 AR ARP990100880A patent/AR018139A1/en unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
-
2000
- 2000-08-04 IS IS5582A patent/IS5582A/en unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/en not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/en unknown
- 2000-09-01 HR HR20000574A patent/HRP20000574A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AP1244A (en) | 2004-02-04 |
| AP2000001893A0 (en) | 2000-09-30 |
| NO20004316L (en) | 2000-11-06 |
| ID25591A (en) | 2000-10-19 |
| AU753230B2 (en) | 2002-10-10 |
| AU3294799A (en) | 1999-09-20 |
| HRP20000574A2 (en) | 2001-08-31 |
| MY123908A (en) | 2006-06-30 |
| AR018139A1 (en) | 2001-10-31 |
| CN1214011C (en) | 2005-08-10 |
| SK13002000A3 (en) | 2001-07-10 |
| IS5582A (en) | 2000-08-04 |
| GEP20033118B (en) | 2003-11-25 |
| BG104740A (en) | 2001-02-28 |
| ZA994406B (en) | 2000-02-11 |
| WO1999044994A1 (en) | 1999-09-10 |
| KR20010041584A (en) | 2001-05-25 |
| CN1291978A (en) | 2001-04-18 |
| EP1060164A1 (en) | 2000-12-20 |
| HUP0100865A2 (en) | 2001-08-28 |
| PL342726A1 (en) | 2001-07-02 |
| NZ506598A (en) | 2003-07-25 |
| BR9908470A (en) | 2000-12-05 |
| EA200000804A1 (en) | 2001-04-23 |
| OA11530A (en) | 2004-05-17 |
| HUP0100865A3 (en) | 2001-11-28 |
| NO315703B1 (en) | 2003-10-13 |
| UA71906C2 (en) | 2005-01-17 |
| EE200000506A (en) | 2002-04-15 |
| YU52000A (en) | 2003-02-28 |
| CA2322207A1 (en) | 1999-09-10 |
| NO20004316D0 (en) | 2000-08-30 |
| IL137653A0 (en) | 2001-10-31 |
| JP2002505323A (en) | 2002-02-19 |
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