TR200000453T2 - Trombosit sayılarını düşürmeye mahsus yöntem. - Google Patents
Trombosit sayılarını düşürmeye mahsus yöntem.Info
- Publication number
- TR200000453T2 TR200000453T2 TR2000/00453T TR200000453T TR200000453T2 TR 200000453 T2 TR200000453 T2 TR 200000453T2 TR 2000/00453 T TR2000/00453 T TR 2000/00453T TR 200000453 T TR200000453 T TR 200000453T TR 200000453 T2 TR200000453 T2 TR 200000453T2
- Authority
- TR
- Turkey
- Prior art keywords
- platelet counts
- formula
- decreasing platelet
- decreasing
- coar
- Prior art date
Links
- 230000003247 decreasing effect Effects 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 hexamethyleneimino Chemical group 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
(Formül (I)). Bir insanda trombosit sayisinin güvenli olarak düsürülmesinin yöntemi olup, ki bu, buna ihtiyaç duyan bir insana, formül I'in, ki içinde, R1 ve R3, bagimsiz olarak, -H, -CH3, -CO(C1-C6 alkil), ya da -COAr olup, burada, Ar, istege bagli olarak, degistirilmis fenil'dir; R3, pirolidin, piperidin, ve heksametileneimino'dan ibaret olan gruptan; ya da, bunlarin eczacilik ile ilgili olarak kabul edilebilir bir tuzu ya da eriyen sivi ile birlesiminden seçilmektedir, bir bilesiginin tesirli bir miktarinin verilmesini ihtiva etmektedir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5620397P | 1997-08-21 | 1997-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000453T2 true TR200000453T2 (tr) | 2000-08-21 |
Family
ID=22002873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00453T TR200000453T2 (tr) | 1997-08-21 | 1998-08-17 | Trombosit sayılarını düşürmeye mahsus yöntem. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6103740A (tr) |
| EP (1) | EP0904783B1 (tr) |
| JP (1) | JP2001515015A (tr) |
| KR (1) | KR20010023075A (tr) |
| CN (1) | CN1275886A (tr) |
| AT (1) | ATE220905T1 (tr) |
| AU (1) | AU741882B2 (tr) |
| BR (1) | BR9811962A (tr) |
| CA (1) | CA2301806A1 (tr) |
| DE (1) | DE69806705T2 (tr) |
| DK (1) | DK0904783T3 (tr) |
| EA (1) | EA001582B1 (tr) |
| ES (1) | ES2181132T3 (tr) |
| HR (1) | HRP20000094A2 (tr) |
| HU (1) | HUP0002715A3 (tr) |
| IL (1) | IL134551A0 (tr) |
| NO (1) | NO20000750L (tr) |
| NZ (1) | NZ502842A (tr) |
| PL (1) | PL338700A1 (tr) |
| PT (1) | PT904783E (tr) |
| TR (1) | TR200000453T2 (tr) |
| WO (1) | WO1999008525A1 (tr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9624800D0 (en) * | 1996-11-29 | 1997-01-15 | Lilly Co Eli | Methods of preventing breast cancer |
| US6353003B1 (en) | 1998-06-17 | 2002-03-05 | Eli Lilly And Company | Method for reducing levels of homocysteine and C-reactive protein |
| WO2001021163A2 (en) * | 1999-09-21 | 2001-03-29 | Emory University | Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents |
| US8021854B2 (en) * | 2007-10-05 | 2011-09-20 | Attila Mady | Method of treating vascular disease |
| US20090092693A1 (en) * | 2007-10-05 | 2009-04-09 | Mady Attila | Platelet manipulation to prevent and treat endovascular disease and its sequelae, to prevent and treat arrhythmias and to prevent malignancy |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US4447620A (en) * | 1982-06-08 | 1984-05-08 | The Upjohn Company | Imidazolyl-substituted benzothiophenes |
| US5075321A (en) * | 1987-03-24 | 1991-12-24 | University Of Pennsylvania | Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes |
| US4847276A (en) * | 1988-09-06 | 1989-07-11 | Merrell Dow Pharmaceuticals Inc. | Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione |
| JPH0517357A (ja) * | 1991-07-05 | 1993-01-26 | Nissan Chem Ind Ltd | 血小板減少療法剤 |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US5445941A (en) * | 1993-06-21 | 1995-08-29 | Eli Lilly And Company | Method for screening anti-osteoporosis agents |
| US5391557A (en) * | 1993-10-15 | 1995-02-21 | Eli Lilly And Company | Methods for the treatment of peri-menopausal syndrome |
| US5441965A (en) * | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting thrombin |
| US5476862A (en) * | 1993-12-21 | 1995-12-19 | Eli Lilly And Company | Methods of increasing thrombomodulin expression |
| US6025373A (en) * | 1997-04-22 | 2000-02-15 | Eli Lilly And Company | Methods for reducing fibrinogen |
-
1998
- 1998-08-04 US US09/129,324 patent/US6103740A/en not_active Expired - Fee Related
- 1998-08-17 IL IL13455198A patent/IL134551A0/xx unknown
- 1998-08-17 CN CN98810105A patent/CN1275886A/zh active Pending
- 1998-08-17 JP JP2000509285A patent/JP2001515015A/ja not_active Withdrawn
- 1998-08-17 PL PL98338700A patent/PL338700A1/xx unknown
- 1998-08-17 TR TR2000/00453T patent/TR200000453T2/tr unknown
- 1998-08-17 HU HU0002715A patent/HUP0002715A3/hu unknown
- 1998-08-17 KR KR1020007001694A patent/KR20010023075A/ko not_active Application Discontinuation
- 1998-08-17 NZ NZ502842A patent/NZ502842A/en unknown
- 1998-08-17 WO PCT/US1998/017018 patent/WO1999008525A1/en not_active Application Discontinuation
- 1998-08-17 AU AU88306/98A patent/AU741882B2/en not_active Ceased
- 1998-08-17 CA CA002301806A patent/CA2301806A1/en not_active Abandoned
- 1998-08-17 BR BR9811962-1A patent/BR9811962A/pt not_active IP Right Cessation
- 1998-08-17 EA EA200000243A patent/EA001582B1/ru not_active IP Right Cessation
- 1998-08-18 DE DE69806705T patent/DE69806705T2/de not_active Expired - Fee Related
- 1998-08-18 EP EP98306570A patent/EP0904783B1/en not_active Expired - Lifetime
- 1998-08-18 ES ES98306570T patent/ES2181132T3/es not_active Expired - Lifetime
- 1998-08-18 PT PT98306570T patent/PT904783E/pt unknown
- 1998-08-18 AT AT98306570T patent/ATE220905T1/de not_active IP Right Cessation
- 1998-08-18 DK DK98306570T patent/DK0904783T3/da active
-
2000
- 2000-02-15 NO NO20000750A patent/NO20000750L/no unknown
- 2000-02-21 HR HR20000094A patent/HRP20000094A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA200000243A1 (ru) | 2000-10-30 |
| AU8830698A (en) | 1999-03-08 |
| DK0904783T3 (da) | 2002-09-02 |
| JP2001515015A (ja) | 2001-09-18 |
| NO20000750L (no) | 2000-04-13 |
| AU741882B2 (en) | 2001-12-13 |
| DE69806705T2 (de) | 2003-03-20 |
| US6103740A (en) | 2000-08-15 |
| ATE220905T1 (de) | 2002-08-15 |
| WO1999008525A1 (en) | 1999-02-25 |
| NO20000750D0 (no) | 2000-02-15 |
| CN1275886A (zh) | 2000-12-06 |
| DE69806705D1 (de) | 2002-08-29 |
| HRP20000094A2 (en) | 2000-08-31 |
| BR9811962A (pt) | 2000-08-15 |
| ES2181132T3 (es) | 2003-02-16 |
| NZ502842A (en) | 2001-11-30 |
| CA2301806A1 (en) | 1999-02-25 |
| PL338700A1 (en) | 2000-11-20 |
| EA001582B1 (ru) | 2001-06-25 |
| KR20010023075A (ko) | 2001-03-26 |
| IL134551A0 (en) | 2001-04-30 |
| HUP0002715A2 (hu) | 2001-06-28 |
| EP0904783B1 (en) | 2002-07-24 |
| PT904783E (pt) | 2002-10-31 |
| EP0904783A1 (en) | 1999-03-31 |
| HUP0002715A3 (en) | 2002-12-28 |
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