TR199701105T1 - � midazo (1,2-a) pyridin t � revleri. - Google Patents
� midazo (1,2-a) pyridin t � revleri.Info
- Publication number
- TR199701105T1 TR199701105T1 TR97/01105T TR9701105T TR199701105T1 TR 199701105 T1 TR199701105 T1 TR 199701105T1 TR 97/01105 T TR97/01105 T TR 97/01105T TR 9701105 T TR9701105 T TR 9701105T TR 199701105 T1 TR199701105 T1 TR 199701105T1
- Authority
- TR
- Turkey
- Prior art keywords
- alkyl
- formula
- revleri
- midazo
- pyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Bu bulus formul (I) e sahip bilesikler ve bunlarin farmasötik açidan kabuledilebilir türevlerini saglar; bu formülde: R0 halojeni temsil eder; R1 ve R2 bagimsiz olarak H, halojen, C1-4 alkil, bir veya daha fazla flor atomu ile sübstitüde edilmis C1-4 alkil, C1-4 alkoksi, C1-4 hidroksialkil, SC1-4 alkil, C(O)H veya C(O)C1-4 alkilden seçilir; ve R3 C1-4 alkili temsil eder.Formül (I) e sahip bilesikler, COX-2 için güçlü ve seçimli inhibitörlerdir ve çesitli saglik durumu ve hastalik ile baglantili agri, ates ve enflamasyonun tedavisinde kullanim için yararlidirlar.This invention provides compounds of formula (I) and their pharmaceutically acceptable derivatives; in this formula: R0 represents halogen; R1 and R2 are independently substituted with H, halogen, C1-4 alkyl, C1-4 alkyl substituted with one or more fluorine atoms, C1-4 alkoxy, C1-4 hydroxyalkyl, SC1-4 alkyl, C (O) H or C (O) selected from C1-4 alkyl; and R3 represents C1-4 alkyl. Compounds of formula (I) are potent and selective inhibitors for COX-2 and are useful for use in the treatment of various health conditions and disease-related pain, fever and inflammation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9506965.4A GB9506965D0 (en) | 1995-04-04 | 1995-04-04 | Chemical compounds |
| GBGB9512099.4A GB9512099D0 (en) | 1995-06-14 | 1995-06-14 | Chemical compounds |
| GBGB9516117.0A GB9516117D0 (en) | 1995-08-05 | 1995-08-05 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199701105T1 true TR199701105T1 (en) | 1998-02-21 |
Family
ID=27267657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR97/01105T TR199701105T1 (en) | 1995-04-04 | 1996-04-02 | � midazo (1,2-a) pyridin t � revleri. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0819127A1 (en) |
| JP (1) | JPH11501049A (en) |
| KR (1) | KR19980703559A (en) |
| CN (1) | CN1186492A (en) |
| AU (1) | AU5276696A (en) |
| BG (1) | BG101934A (en) |
| CA (1) | CA2216809A1 (en) |
| CZ (1) | CZ313397A3 (en) |
| EA (1) | EA199700209A1 (en) |
| HU (1) | HUP9801602A3 (en) |
| IS (1) | IS4570A (en) |
| NO (1) | NO974595L (en) |
| NZ (1) | NZ304886A (en) |
| PL (1) | PL322623A1 (en) |
| SK (1) | SK133297A3 (en) |
| TR (1) | TR199701105T1 (en) |
| WO (1) | WO1996031509A1 (en) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2764292B1 (en) * | 1997-06-10 | 2000-12-29 | Innothera Lab Sa | USE OF DICETONIC TETRACYCLE DERIVATIVES, NOVEL COMPOUNDS OBTAINED AND THEIR APPLICATION IN THERAPEUTICS |
| US6525053B1 (en) | 1997-08-22 | 2003-02-25 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| US6307047B1 (en) | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| EP1032575B1 (en) | 1997-09-05 | 2003-07-23 | Glaxo Group Limited | 2,3-diaryl-pyrazolo(1,5-b)pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (cox-2) inhibitors |
| FR2770131A1 (en) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Analgesic combinations of a cyclooxygenase-2 inhibitor and acetaminophen or an opiate having synergistic activity |
| FR2771005B1 (en) * | 1997-11-18 | 2002-06-07 | Union Pharma Scient Appl | NEW PHARMACEUTICAL ASSOCIATION WITH ANALGESIC ACTIVITY |
| GB9810920D0 (en) * | 1998-05-21 | 1998-07-22 | Merck Sharp & Dohme | Therapeutic use |
| ES2140354B1 (en) * | 1998-08-03 | 2000-11-01 | S A L V A T Lab Sa | IMIDAZO (1,2A) AZINAS SUBSTITUTED AS SELECTIVE INHIBITORS OF COX-2. |
| TW587079B (en) * | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
| KR20010075673A (en) * | 1998-11-03 | 2001-08-09 | 그레이엄 브레레톤, 레슬리 에드워즈 | Pyrazolopyridine Derivatives as Selective COX-2 Inhibitors |
| AU2661400A (en) | 1999-02-27 | 2000-09-21 | Glaxo Group Limited | Pyrazolopyridines |
| GB9930358D0 (en) | 1999-12-22 | 2000-02-09 | Glaxo Group Ltd | Process for the preparation of chemical compounds |
| MXPA02006312A (en) | 1999-12-23 | 2004-06-21 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase2 inhibitors, compositions and methods of use. |
| GB0002312D0 (en) * | 2000-02-01 | 2000-03-22 | Glaxo Group Ltd | Medicaments |
| PE20011333A1 (en) | 2000-03-16 | 2002-01-16 | Almirall Prodesfarma Ag | DERIVATIVES OF 2-FENYLPYRAN-4-ONA AS INHIBITORS OF CYCLOOXYGENASE 2 |
| PE20020146A1 (en) * | 2000-07-13 | 2002-03-31 | Upjohn Co | OPHTHALMIC FORMULATION INCLUDING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR |
| HUP0302068A3 (en) | 2000-07-20 | 2005-05-30 | Lauras As | Use of cox-2 inhibitors for treating or preventing immunodeficiency and pharmaceutical compositions containing them |
| PE20020506A1 (en) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | PIRAZOLE DERIVATIVES FUSED AS PROTEIN KINASE INHIBITORS |
| GB0025449D0 (en) * | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
| EP1377573B1 (en) | 2000-12-15 | 2005-07-27 | Glaxo Group Limited | Pyrazolopyridine derivatives |
| ES2245380T3 (en) | 2000-12-15 | 2006-01-01 | Glaxo Group Limited | PIRAZOLOPIRIDINAS. |
| US7153855B2 (en) | 2001-03-08 | 2006-12-26 | Smithkline Beecham Corporation | Pyrazolopyridinyl pyrimidine therapeutic compounds |
| US7034030B2 (en) | 2001-03-30 | 2006-04-25 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapeutic compounds |
| PE20021017A1 (en) | 2001-04-03 | 2002-11-24 | Pharmacia Corp | RECONSTITUABLE PARENTERAL COMPOSITION |
| WO2002083672A1 (en) | 2001-04-10 | 2002-10-24 | Smithkline Beecham Corporation | Antiviral pyrazolopyridine compounds |
| US6962914B2 (en) | 2001-04-27 | 2005-11-08 | Smithkline Beecham Corporation | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds |
| US6756498B2 (en) | 2001-04-27 | 2004-06-29 | Smithkline Beecham Corporation | Process for the preparation of chemical compounds |
| CZ20033518A3 (en) | 2001-06-21 | 2004-05-12 | Smithklineábeechamácorporation | Imidazo(1,2-a)pyridine derivatives for the prophylaxis and treatment of herpes viral infections |
| AR038957A1 (en) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | COMBINATION THERAPY FOR CANCER TREATMENT |
| JP2005508955A (en) | 2001-10-05 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | Imidazo-pyridine derivatives for use in the treatment of herpesvirus infections |
| GB0124931D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124938D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| ATE373000T1 (en) | 2001-12-11 | 2007-09-15 | Smithkline Beecham Corp | PYRAZOLOPYRIDINE DERIVATIVES AS ANTHERPESICS |
| JP4472349B2 (en) | 2002-02-12 | 2010-06-02 | スミスクライン ビーチャム コーポレーション | Nicotinamide derivatives useful as p38 inhibitors |
| JP2005535642A (en) | 2002-06-28 | 2005-11-24 | ニトロメッド インコーポレーティッド | Nitrosated and / or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use containing oximes and / or hydrazones |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| AU2003275266A1 (en) | 2002-10-03 | 2004-05-04 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridine derivatives |
| KR20040072004A (en) | 2003-02-07 | 2004-08-16 | 삼성에스디아이 주식회사 | Emitting compound for electroluminescence device and device using thereof |
| GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| PL1534305T3 (en) | 2003-05-07 | 2007-03-30 | Osteologix As | Treating cartilage / bone conditions with water-soluble strontium salts |
| GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
| EP1915157A4 (en) | 2005-08-02 | 2010-09-01 | Nicox Sa | Nitric oxide enhancing antimicrobial compounds, compositions and methods of use |
| WO2007126609A1 (en) | 2006-03-29 | 2007-11-08 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
| MY146474A (en) | 2006-11-06 | 2012-08-15 | Supergen Inc | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| PL3409278T3 (en) | 2011-07-21 | 2021-02-22 | Sumitomo Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| WO2016177776A1 (en) | 2015-05-04 | 2016-11-10 | Academisch Medisch Centrum | Biomarkers for the detection of aspirin insensitivity |
| WO2020167990A1 (en) | 2019-02-12 | 2020-08-20 | Tolero Pharmaceuticals, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
| CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455924A (en) * | 1967-02-08 | 1969-07-15 | Upjohn Co | Dianisylimidazoles |
-
1996
- 1996-04-02 SK SK1332-97A patent/SK133297A3/en unknown
- 1996-04-02 CZ CZ973133A patent/CZ313397A3/en unknown
- 1996-04-02 KR KR1019970706963A patent/KR19980703559A/en not_active Application Discontinuation
- 1996-04-02 AU AU52766/96A patent/AU5276696A/en not_active Abandoned
- 1996-04-02 PL PL96322623A patent/PL322623A1/en unknown
- 1996-04-02 CN CN96194403A patent/CN1186492A/en active Pending
- 1996-04-02 NZ NZ304886A patent/NZ304886A/en unknown
- 1996-04-02 TR TR97/01105T patent/TR199701105T1/en unknown
- 1996-04-02 WO PCT/EP1996/001438 patent/WO1996031509A1/en not_active Application Discontinuation
- 1996-04-02 HU HU9801602A patent/HUP9801602A3/en unknown
- 1996-04-02 JP JP8529971A patent/JPH11501049A/en active Pending
- 1996-04-02 EA EA199700209A patent/EA199700209A1/en unknown
- 1996-04-02 CA CA002216809A patent/CA2216809A1/en not_active Abandoned
- 1996-04-02 EP EP96909164A patent/EP0819127A1/en not_active Withdrawn
-
1997
- 1997-09-25 IS IS4570A patent/IS4570A/en unknown
- 1997-09-30 BG BG101934A patent/BG101934A/en unknown
- 1997-10-03 NO NO974595A patent/NO974595L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR19980703559A (en) | 1998-11-05 |
| PL322623A1 (en) | 1998-02-02 |
| EA199700209A1 (en) | 1998-04-30 |
| CN1186492A (en) | 1998-07-01 |
| NO974595D0 (en) | 1997-10-03 |
| JPH11501049A (en) | 1999-01-26 |
| WO1996031509A1 (en) | 1996-10-10 |
| CZ313397A3 (en) | 1998-03-18 |
| NZ304886A (en) | 1998-11-25 |
| SK133297A3 (en) | 1998-07-08 |
| EP0819127A1 (en) | 1998-01-21 |
| NO974595L (en) | 1997-12-03 |
| MX9707379A (en) | 1997-11-29 |
| HUP9801602A3 (en) | 1999-01-28 |
| CA2216809A1 (en) | 1996-10-10 |
| HUP9801602A2 (en) | 1998-11-30 |
| IS4570A (en) | 1997-09-25 |
| AU5276696A (en) | 1996-10-23 |
| BG101934A (en) | 1999-04-30 |
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