TR199700508A2 - Orto-ikame edilmis benzoilguanidin'leri, bunlarin imal edilmesine mahsus usul, bunlarin ilaç ya da diyagnoz maddesi olarak kullanilmalari ve ayrica bunlari ihtiva eden ilaçlar. - Google Patents

Orto-ikame edilmis benzoilguanidin'leri, bunlarin imal edilmesine mahsus usul, bunlarin ilaç ya da diyagnoz maddesi olarak kullanilmalari ve ayrica bunlari ihtiva eden ilaçlar.

Info

Publication number
TR199700508A2
TR199700508A2 TR97/00508A TR9700508A TR199700508A2 TR 199700508 A2 TR199700508 A2 TR 199700508A2 TR 97/00508 A TR97/00508 A TR 97/00508A TR 9700508 A TR9700508 A TR 9700508A TR 199700508 A2 TR199700508 A2 TR 199700508A2
Authority
TR
Turkey
Prior art keywords
ischemic
ortho
medicine
manufacture
well
Prior art date
Application number
TR97/00508A
Other languages
English (en)
Inventor
Andreas Weichert Dr.
Joachim Brendel Dr.
Heinz-Werner Kleemann Dr.
Hans Jochen Lang Dr.
Jan-Robert Schwark Dr.
Udo Albus Dr.
Wolfgang Scholz Dr.
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of TR199700508A2 publication Critical patent/TR199700508A2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Formül I'e göre olan benzoilguanidin'leri, ki formülde R(1) ila R(4) istemlerde verilen anlamlari tasimaktadir, kardiyo protektif komponentlere sahip degerli antiaritmik ilaç maddeleri olup, ayrica isemik kaynakli hasarlarin olusumunda, özellikle isemik kaynakli kalp aritmienlerinde hasarlarin olusumunu önleyicidirler. Sözkonusu ilaç maddeleri selülör Na+/H+- degisim mekanizmasinin önlenmesi sonucunda isemik kaynakli akut ya da kronik hasarlarin tedavi edilmesinde kullanilabilmektedir. Ayrica bu ilaçlar hücrelerin profilerasyonu üzerinde kuvvetli önleyici etkiye sahiptirler. Ilaç maddesi yüksek tansiyonunun olusumunu önlemek için kullanilmaya uygundur.
TR97/00508A 1996-06-18 1997-06-16 Orto-ikame edilmis benzoilguanidin'leri, bunlarin imal edilmesine mahsus usul, bunlarin ilaç ya da diyagnoz maddesi olarak kullanilmalari ve ayrica bunlari ihtiva eden ilaçlar. TR199700508A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19624178A DE19624178A1 (de) 1996-06-18 1996-06-18 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
TR199700508A2 true TR199700508A2 (tr) 1998-01-21

Family

ID=7797197

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/00508A TR199700508A2 (tr) 1996-06-18 1997-06-16 Orto-ikame edilmis benzoilguanidin'leri, bunlarin imal edilmesine mahsus usul, bunlarin ilaç ya da diyagnoz maddesi olarak kullanilmalari ve ayrica bunlari ihtiva eden ilaçlar.

Country Status (31)

Country Link
US (1) US6001881A (tr)
EP (1) EP0814077B1 (tr)
JP (1) JP3977897B2 (tr)
KR (1) KR100498799B1 (tr)
CN (1) CN1064676C (tr)
AR (1) AR012536A1 (tr)
AT (1) ATE191469T1 (tr)
AU (1) AU711734B2 (tr)
BR (1) BR9703617A (tr)
CA (1) CA2207886A1 (tr)
CZ (1) CZ291848B6 (tr)
DE (2) DE19624178A1 (tr)
DK (1) DK0814077T3 (tr)
ES (1) ES2146049T3 (tr)
GR (1) GR3033299T3 (tr)
HR (1) HRP970332B1 (tr)
HU (1) HUP9701057A3 (tr)
ID (1) ID17321A (tr)
IL (1) IL121085A0 (tr)
MX (1) MX9704486A (tr)
MY (1) MY117304A (tr)
NO (1) NO307928B1 (tr)
NZ (1) NZ328100A (tr)
PL (1) PL185756B1 (tr)
PT (1) PT814077E (tr)
RU (1) RU2193025C2 (tr)
SI (1) SI0814077T1 (tr)
SK (1) SK282351B6 (tr)
TR (1) TR199700508A2 (tr)
TW (1) TW374759B (tr)
ZA (1) ZA975312B (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19608161A1 (de) * 1996-03-04 1997-09-11 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19713427A1 (de) * 1997-04-01 1998-10-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10001879A1 (de) * 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6641811B1 (en) * 2000-02-10 2003-11-04 Cornell Research Foundation, Inc. Use of angiotensin II inhibitors to prevent malignancies associated with immunosuppression
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4318756A1 (de) * 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4430213A1 (de) * 1994-08-28 1996-02-29 Merck Patent Gmbh Arylbenzoylguanidine
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE19608162A1 (de) * 1996-03-04 1997-09-11 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
MX9704486A (es) 1997-12-31
EP0814077A1 (de) 1997-12-29
SI0814077T1 (en) 2000-08-31
ZA975312B (en) 1998-01-05
IL121085A0 (en) 1997-11-20
MY117304A (en) 2004-06-30
AR012536A1 (es) 2000-11-08
CN1169987A (zh) 1998-01-14
PL320326A1 (en) 1997-12-22
PL185756B1 (pl) 2003-07-31
JPH1067733A (ja) 1998-03-10
TW374759B (en) 1999-11-21
SK282351B6 (sk) 2002-01-07
NO972793L (no) 1997-12-19
HUP9701057A3 (en) 2000-08-28
AU711734B2 (en) 1999-10-21
GR3033299T3 (en) 2000-09-29
CZ291848B6 (cs) 2003-06-18
HU9701057D0 (en) 1997-08-28
NZ328100A (en) 1998-09-24
ID17321A (id) 1997-12-18
US6001881A (en) 1999-12-14
DE19624178A1 (de) 1998-01-08
AU2494297A (en) 1998-01-08
SK76697A3 (en) 1998-01-14
CZ188797A3 (cs) 1998-05-13
NO307928B1 (no) 2000-06-19
ATE191469T1 (de) 2000-04-15
HRP970332A2 (en) 1998-04-30
JP3977897B2 (ja) 2007-09-19
HUP9701057A2 (hu) 1998-12-28
RU2193025C2 (ru) 2002-11-20
DK0814077T3 (da) 2000-08-14
HRP970332B1 (en) 2001-02-28
DE59701388D1 (de) 2000-05-11
CN1064676C (zh) 2001-04-18
NO972793D0 (no) 1997-06-17
PT814077E (pt) 2000-07-31
KR100498799B1 (ko) 2005-12-16
ES2146049T3 (es) 2000-07-16
BR9703617A (pt) 1998-09-29
EP0814077B1 (de) 2000-04-05
CA2207886A1 (en) 1997-12-18
KR980002020A (ko) 1998-03-30

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