DK0825197T3 - Nye 6-hydroxy- og 6-oxo-androstanderivater, der er aktive i forhold til det cardiovaskulære system, og farmaceutiske præpar - Google Patents

Nye 6-hydroxy- og 6-oxo-androstanderivater, der er aktive i forhold til det cardiovaskulære system, og farmaceutiske præpar

Info

Publication number
DK0825197T3
DK0825197T3 DK97111651T DK97111651T DK0825197T3 DK 0825197 T3 DK0825197 T3 DK 0825197T3 DK 97111651 T DK97111651 T DK 97111651T DK 97111651 T DK97111651 T DK 97111651T DK 0825197 T3 DK0825197 T3 DK 0825197T3
Authority
DK
Denmark
Prior art keywords
oxo
hydroxy
relation
new
pharmaceutical preparations
Prior art date
Application number
DK97111651T
Other languages
English (en)
Inventor
Munari Sergio De
Elena Folpini
Piero Melloni
Fulvio Serra
Simona Sputore
Marco Frigerio
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK0825197T3 publication Critical patent/DK0825197T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016Oximes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97111651T 1996-08-19 1997-07-09 Nye 6-hydroxy- og 6-oxo-androstanderivater, der er aktive i forhold til det cardiovaskulære system, og farmaceutiske præpar DK0825197T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19633349A DE19633349A1 (de) 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

Publications (1)

Publication Number Publication Date
DK0825197T3 true DK0825197T3 (da) 2000-10-30

Family

ID=7802998

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97111651T DK0825197T3 (da) 1996-08-19 1997-07-09 Nye 6-hydroxy- og 6-oxo-androstanderivater, der er aktive i forhold til det cardiovaskulære system, og farmaceutiske præpar

Country Status (10)

Country Link
US (1) US5914324A (da)
EP (1) EP0825197B1 (da)
JP (1) JP4297994B2 (da)
AT (1) ATE196768T1 (da)
DE (2) DE19633349A1 (da)
DK (1) DK0825197T3 (da)
ES (1) ES2151698T3 (da)
GR (1) GR3034821T3 (da)
HK (1) HK1009139A1 (da)
PT (1) PT825197E (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1317031B1 (it) * 2000-05-17 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
TWI392682B (zh) * 2006-04-13 2013-04-11 Sigma Tau Ind Farmaceuti 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物
TWI389917B (zh) * 2006-04-13 2013-03-21 Sigma Tau Ind Farmaceuti 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物
TWI372762B (en) * 2006-06-23 2012-09-21 Sigma Tau Ind Farmaceuti Amino derivatives of b-homoandrostanes and b-heteroandrostanes
BRPI0721050A2 (pt) 2006-11-29 2014-07-29 Endece Llc Derivados de 6-alquoxialquil estradiol e métodos de uso
EP2209795B1 (en) * 2007-10-12 2013-04-24 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
WO2012013816A1 (en) * 2010-07-30 2012-02-02 Medexis S.A. Compounds and methods for treating neoplasia
SG188396A1 (en) 2010-09-14 2013-04-30 Endece Llc 6-substituted demethyl-estradiol derivatives as er-beta agonists
CN103315968B (zh) * 2013-06-26 2015-04-01 中国生命药物治疗有限公司 一种注射用粉针剂及其制备方法
CN103360457B (zh) * 2013-07-31 2015-10-07 中国生命药物治疗有限公司 一种雄甾烷二酮衍生物晶型及其制备方法
PL3599243T3 (pl) 2018-07-26 2023-08-21 Cvie Therapeutics Limited Związki podobne do 17beta-heterocyklilu naparstnicy do leczenia niewydolności serca
SG11202108488SA (en) 2019-03-05 2021-09-29 Windtree Therapeutics Inc Istaroxime-containing intravenous formulation for the treatment of acute heart failure (ahf)
PL3805243T3 (pl) 2019-10-09 2024-03-18 Windtree Therapeutics, Inc. Pochodne androstanowe posiadające aktywność jako czyste lub w przeważającym stopniu czyste stymulatory SERCA2A do leczenia niewydolności serca

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863885A (en) * 1958-02-10 1958-12-09 Upjohn Co 17-isonitrosoandrostanes
GB1175219A (en) * 1967-06-22 1969-12-23 Ici Ltd 3-Aminoalkoxycarbonylmethylene Steroid Derivatives
CH504427A (de) * 1967-12-06 1971-03-15 Ciba Geigy Ag Verfahren zur Herstellung neuer 4-Imino-19-nor-A-homosteroid-triene
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
DE4227605C2 (de) * 1992-08-20 1995-02-16 Sigma Tau Ind Farmaceuti 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
DE4344236A1 (de) * 1993-12-23 1995-06-29 Sigma Tau Ind Farmaceuti Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten

Also Published As

Publication number Publication date
DE69703228D1 (de) 2000-11-09
US5914324A (en) 1999-06-22
GR3034821T3 (en) 2001-02-28
JP4297994B2 (ja) 2009-07-15
EP0825197A3 (en) 1999-04-14
PT825197E (pt) 2001-01-31
EP0825197A2 (en) 1998-02-25
ES2151698T3 (es) 2001-01-01
DE19633349A1 (de) 1998-02-26
EP0825197B1 (en) 2000-10-04
ATE196768T1 (de) 2000-10-15
JPH1077292A (ja) 1998-03-24
DE69703228T2 (de) 2001-02-22
HK1009139A1 (en) 1999-05-28

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