TNSN98012A1 - Composes inhibant les metalloproteases. - Google Patents

Composes inhibant les metalloproteases.

Info

Publication number
TNSN98012A1
TNSN98012A1 TNTNSN98012A TNSN98012A TNSN98012A1 TN SN98012 A1 TNSN98012 A1 TN SN98012A1 TN TNSN98012 A TNTNSN98012 A TN TNSN98012A TN SN98012 A TNSN98012 A TN SN98012A TN SN98012 A1 TNSN98012 A1 TN SN98012A1
Authority
TN
Tunisia
Prior art keywords
compounds inhibiting
metalloproteases
inhibiting metalloproteases
compounds
methods
Prior art date
Application number
TNTNSN98012A
Other languages
English (en)
Inventor
Lucas Castelhano Arlindo
Joseph Melnick Michael
Allen Broka Chris
Allen Campbell Jeffrey
Adrian Murray Walker Keith
Jeffrey Chen Jian
Than Hendricks Robert
Original Assignee
Hoffmann La Roche Ag Et Agouron Pharmaceuticals Inc F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26713422&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN98012(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche Ag Et Agouron Pharmaceuticals Inc F filed Critical Hoffmann La Roche Ag Et Agouron Pharmaceuticals Inc F
Publication of TNSN98012A1 publication Critical patent/TNSN98012A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

CETTE INVENTION A TRAIT AUX SULFAMIDES DE FORMULE (1) DANS LAQUELLE R1, R2, R3; R10, R20, R21 SONT TELS QUE DEFINIS DANS LA DESCRIPTION ET LES REVENDICATIONS, QUI SONT DES INHIBITEURS DES METALLOPROTEASES, LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, LES PROCEDES POUR LEUR UTILISATION ET PROCEDES POUR PREPARER CES COMPOSES.
TNTNSN98012A 1997-01-23 1998-01-22 Composes inhibant les metalloproteases. TNSN98012A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3671497P 1997-01-23 1997-01-23
US6220997P 1997-10-16 1997-10-16

Publications (1)

Publication Number Publication Date
TNSN98012A1 true TNSN98012A1 (fr) 2005-03-15

Family

ID=26713422

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN98012A TNSN98012A1 (fr) 1997-01-23 1998-01-22 Composes inhibant les metalloproteases.

Country Status (35)

Country Link
EP (1) EP0958287B2 (fr)
JP (1) JP3563411B2 (fr)
KR (1) KR100377696B1 (fr)
CN (1) CN1093125C (fr)
AR (1) AR011425A1 (fr)
AT (1) ATE223909T1 (fr)
AU (1) AU730127B2 (fr)
BG (1) BG103586A (fr)
BR (1) BR9807508A (fr)
CA (1) CA2278694C (fr)
DE (2) DE69807845T2 (fr)
DK (1) DK0958287T3 (fr)
EA (1) EA002810B1 (fr)
ES (2) ES2183331T3 (fr)
FR (1) FR2758559A1 (fr)
GB (1) GB2321641B (fr)
HR (1) HRP980036A2 (fr)
HU (1) HUP0000941A3 (fr)
ID (1) ID22849A (fr)
IL (1) IL130802A0 (fr)
IS (1) IS5125A (fr)
IT (1) IT1298163B1 (fr)
MA (1) MA26467A1 (fr)
NO (1) NO313635B1 (fr)
NZ (1) NZ336625A (fr)
OA (1) OA11078A (fr)
PA (1) PA8445301A1 (fr)
PE (1) PE57399A1 (fr)
PL (1) PL334846A1 (fr)
PT (1) PT958287E (fr)
TN (1) TNSN98012A1 (fr)
TR (1) TR199901765T2 (fr)
UY (1) UY24854A1 (fr)
WO (1) WO1998032748A1 (fr)
YU (1) YU34599A (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9919776D0 (en) * 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
HN2000000052A (es) * 1999-05-28 2001-02-02 Pfizer Prod Inc Hidroxiamidas de acidos 3- (arilsulfonilamino)- tetrahidrofuran-3-carboxilicos.
EP1187811B1 (fr) * 1999-06-04 2007-03-07 AstraZeneca AB Inhibiteurs de metalloproteases
CA2378332A1 (fr) 1999-08-18 2001-02-22 Christopher Alan Conrad Composes d'acide hydroxamique utiles comme inhibiteurs de metalloproteinases matricielles
DOP2000000107A (es) 1999-12-01 2002-09-16 Agouron Pharmaceutical Inc Compuestos, composiciones y metodos para estimular el crecimiento y alongamiento de las neuronas
JP2003524007A (ja) * 2000-02-21 2003-08-12 アストラゼネカ・アクチエボラーグ アリールピペラジン類およびそれらのメタロプロテイナーゼ阻害剤（ｍｍｐ）としての使用
CN1247547C (zh) 2000-02-21 2006-03-29 阿斯特拉曾尼卡有限公司 作为金属蛋白酶抑制剂的哌啶和哌嗪取代的n－羟基甲酰胺
US6495358B1 (en) * 2000-04-19 2002-12-17 Wichita State University Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes
WO2001083431A1 (fr) * 2000-04-28 2001-11-08 Shionogi & Co., Ltd. Inhibiteurs de mmp-12
US6492171B2 (en) 2000-05-16 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of TERT expression
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
GB0119474D0 (en) 2001-08-09 2001-10-03 Astrazeneca Ab Compounds
WO2003035610A1 (fr) * 2001-10-26 2003-05-01 Shionogi & Co., Ltd. Derive de sulfonamide a effet inhibiteur sur les mmp
MXPA04009490A (es) * 2002-04-03 2005-06-08 Topo Target Uk Ltd Compuesto de acido carbamico que comprenden un enlace de piperazina como inhibidores de histona desacetilasa.
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
ES2425013T3 (es) * 2002-06-12 2013-10-10 Symphony Evolution, Inc. Inhibidores de ADAM-10 humana
EP1493445A1 (fr) * 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition de l'activation de l'EGFR, cette activation étant dépendante d'un ligand et étant induite par le stress
DE10344936A1 (de) * 2003-09-27 2005-04-21 Aventis Pharma Gmbh Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen
JP2007538054A (ja) * 2004-05-19 2007-12-27 ゾルファイ　ファーマスーティカルズ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング 肥満および関係する病気の予防または治療のためのｎ−スルファモイル−ｎ′−アリールピペラジンを含有する薬剤
TW200626138A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
DE102004060229A1 (de) * 2004-12-15 2006-06-29 Sanofi-Aventis Deutschland Gmbh Neue zyklische Harnstoffe als Inhibitoren von Metallproteasen
US20090069304A1 (en) * 2006-03-03 2009-03-12 Shionogi & Co., Ltd. Mmp-13 selective inhibitor
EP2128134A1 (fr) 2006-11-02 2009-12-02 Shionogi&Co., Ltd. Dérivé de sulfonylurée capable d'inhiber sélectivement mmp-13
WO2008147764A1 (fr) * 2007-05-23 2008-12-04 Array Biopharma, Inc. Inhibiteurs des métalloprotéases matricielles (mmp) et leurs méthodes d'utilisation
EP2200978A1 (fr) 2007-10-12 2010-06-30 Basf Se Procede de production de diamides sulfoniques
FR2947268B1 (fr) 2009-06-30 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
EP2456757B1 (fr) * 2009-07-22 2019-05-01 The Board of Trustees of the University of Illionis Inhibiteurs de hdac et procédés thérapeutiques les utilisant
CA2836487A1 (fr) * 2011-06-09 2012-12-13 Rhizen Pharmaceuticals Sa Nouveaux composes utilises comme modulateurs de gpr-119
BR112017024952A2 (pt) 2015-05-22 2018-07-31 Chong Kun Dang Pharmaceutical Corp compostos derivados de alquila heterocíclica como inibidores seletivos de histona desacetilase e composições farmacêuticas, compreendendo os mesmos
BR112021006407A8 (pt) 2018-10-04 2022-12-06 Inst Nat Sante Rech Med uso de inibidores do egfr para ceratodermas

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH617318A5 (en) † 1975-09-30 1980-05-30 Ciba Geigy Ag Microbicidal composition.
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5114937A (en) * 1989-11-28 1992-05-19 Warner-Lambert Company Renin inhibiting nonpeptides
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
WO1993006127A1 (fr) * 1991-09-17 1993-04-01 Warner-Lambert Company Nouveaux inhibiteurs de renine a base de promedicaments a acides amines
GB9211707D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
EP0758317B1 (fr) † 1994-05-04 1999-04-07 Novartis AG Amides d'acides amines n-sulfonyle et n-sulfinyle en tant que microbicides
DE19507447A1 (de) † 1995-03-03 1996-09-05 Vitronic Dr Ing Stein Bildvera Verfahren und Schaltung zum Erfassen und Weiterleiten von Videobilddaten in einem PC
ATE213232T1 (de) * 1995-11-13 2002-02-15 Hoechst Ag Cyclische und heterocyclische n-substituierte alpha-iminohydroxam- und carbonsäuren
ATE225343T1 (de) * 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
FR2748026B1 (fr) * 1996-04-26 1998-06-05 Adir Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
DE69807845D1 (de) 2002-10-17
ATE223909T1 (de) 2002-09-15
JP3563411B2 (ja) 2004-09-08
JP2001523222A (ja) 2001-11-20
ES2136037A1 (es) 1999-11-01
IT1298163B1 (it) 1999-12-20
OA11078A (en) 2003-03-17
HUP0000941A3 (en) 2002-06-28
HUP0000941A2 (hu) 2001-04-28
WO1998032748A1 (fr) 1998-07-30
NO993587L (no) 1999-09-22
NZ336625A (en) 2001-04-27
GB2321641B (en) 2001-04-04
YU34599A (sh) 2002-03-18
EA002810B1 (ru) 2002-10-31
KR100377696B1 (ko) 2003-03-29
DE19802350A1 (de) 1998-07-30
CA2278694A1 (fr) 1998-07-30
EP0958287A1 (fr) 1999-11-24
IL130802A0 (en) 2001-01-28
BR9807508A (pt) 2000-03-21
CA2278694C (fr) 2006-09-26
UY24854A1 (es) 2000-12-29
NO993587D0 (no) 1999-07-22
PL334846A1 (en) 2000-03-27
ES2136037B1 (es) 2000-11-16
PE57399A1 (es) 1999-06-25
FR2758559A1 (fr) 1998-07-24
KR20000070398A (ko) 2000-11-25
CN1093125C (zh) 2002-10-23
DK0958287T3 (da) 2003-01-20
EP0958287B2 (fr) 2008-04-09
EA199900643A1 (ru) 2000-04-24
MA26467A1 (fr) 2004-12-20
AU730127B2 (en) 2001-02-22
GB9801393D0 (en) 1998-03-18
BG103586A (bg) 2000-03-31
HRP980036A2 (en) 1998-12-31
TR199901765T2 (xx) 1999-10-21
NO313635B1 (no) 2002-11-04
GB2321641A (en) 1998-08-05
ID22849A (id) 1999-12-09
AR011425A1 (es) 2000-08-16
ITMI980091A1 (it) 1999-07-20
AU6614098A (en) 1998-08-18
PA8445301A1 (es) 2001-07-31
CN1250445A (zh) 2000-04-12
PT958287E (pt) 2002-12-31
ES2183331T3 (es) 2003-03-16
IS5125A (is) 1999-07-22
DE69807845T2 (de) 2003-06-05
EP0958287B1 (fr) 2002-09-11

Similar Documents

Publication Publication Date Title
TNSN98012A1 (fr) Composes inhibant les metalloproteases.
MA26697A1 (fr) Composes nouveaux inhibiteurs de gsk-3 et compositions pharmaceutiques les contenant
TNSN97144A1 (fr) Derives 6,6-heterobicycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN97110A1 (fr) Derives de 2-(2-oxo-ethylidene)-imidazolidine-4-one, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN98084A1 (fr) Derives de macrolides substitues en position c-4
TNSN99171A1 (fr) 4-carboxyamino-2-substitue-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN97056A1 (fr) Derives de lactames, procede pour leur preparation et compositions pharmaceutiques les contenant.
TNSN01102A1 (fr) Derives de pyrazole nouveaux, procede pour leur preparation et compositions les contenant.
TNSN97197A1 (fr) Derives de pyrazole parasiticides, procede pour leur preparation et compositions les contenant.
TNSN99126A1 (fr) Pyrrolopyrimidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
BG103485A (en) Ketobanzamides as calpain inhibitors
TNSN99170A1 (fr) Derives de tetrahydroquinoleine substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA24729A1 (fr) Macrolides nouveaux.
IL133825A0 (en) Substituted 6-phenylphenanthridines, medicaments containing same and use thereof
TNSN01048A1 (fr) Acides malonamiques et leurs derives, et compositions les contenant
NZ290420A (en) Phenyl or pyridyl-amide substituted dihydro benzofurans; medicaments
TNSN97015A1 (fr) Nouveaux derives de 19-nor-pregnene.
TNSN99147A1 (fr) Procede d'emulsification
TNSN97044A1 (fr) Derives de quinoxalinedone, procedes et intermediaires pour leur preparation, et compositions pharmaceutiques les contenant.
ZA955105B (en) Thiazolidine derivatives their preparation and compositions containing them
FI970147A (fi) Triatsoliyhdisteitä ja niiden käyttö dopamiini-D3-ligandeina
TNSN01126A1 (fr) Imidazoles substitues nouveaux, procede pour leur preparation et compositions les contenant
IL117209A (en) 1-aryl-2-acylamino-ethane compounds and pharmaceutical compositions containing them
DE69709883T2 (de) Chirale ferrocene
TNSN98013A1 (fr) Derives de 5 - aroylnaphtalene a action anti-inflammatoire et analgesique, compositions pharmaceutiques les contenant, et procedes pour les utiliser et les preparer.