TN2014000500A1 - Dimethyl-benzoic acid compounds - Google Patents

Dimethyl-benzoic acid compounds

Info

Publication number
TN2014000500A1
TN2014000500A1 TN2014000500A TN2014000500A TN2014000500A1 TN 2014000500 A1 TN2014000500 A1 TN 2014000500A1 TN 2014000500 A TN2014000500 A TN 2014000500A TN 2014000500 A TN2014000500 A TN 2014000500A TN 2014000500 A1 TN2014000500 A1 TN 2014000500A1
Authority
TN
Tunisia
Prior art keywords
dimethyl
benzoic acid
acid compounds
compounds
och
Prior art date
Application number
TN2014000500A
Other languages
English (en)
Inventor
Maria-Jesus Blanco-Pillado
Tatiana Natali Vetman
Matthew Joseph Fisher
Steven Lee Kuklish
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TN2014000500A1 publication Critical patent/TN2014000500A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/42Oxygen atoms attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/113Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
TN2014000500A 2012-06-29 2014-11-28 Dimethyl-benzoic acid compounds TN2014000500A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261665956P 2012-06-29 2012-06-29
US201361778969P 2013-03-13 2013-03-13
PCT/US2013/046685 WO2014004230A1 (fr) 2012-06-29 2013-06-20 Composés acide diméthyl-benzoïque

Publications (1)

Publication Number Publication Date
TN2014000500A1 true TN2014000500A1 (en) 2016-03-30

Family

ID=48746667

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2014000500A TN2014000500A1 (en) 2012-06-29 2014-11-28 Dimethyl-benzoic acid compounds

Country Status (41)

Country Link
US (2) US8642768B2 (fr)
EP (1) EP2867218B1 (fr)
JP (1) JP6114824B2 (fr)
KR (1) KR101634032B1 (fr)
CN (1) CN104334540B (fr)
AP (1) AP4063A (fr)
AR (1) AR091431A1 (fr)
AU (1) AU2013280779B2 (fr)
BR (1) BR112014029551A2 (fr)
CA (1) CA2875572C (fr)
CL (1) CL2014003537A1 (fr)
CO (1) CO7160064A2 (fr)
CR (1) CR20140554A (fr)
CY (1) CY1118830T1 (fr)
DK (1) DK2867218T3 (fr)
DO (1) DOP2014000286A (fr)
EA (1) EA025531B1 (fr)
ES (1) ES2623099T3 (fr)
GT (1) GT201400289A (fr)
HK (1) HK1203936A1 (fr)
HR (1) HRP20170540T1 (fr)
HU (1) HUE032398T2 (fr)
IL (1) IL236218A (fr)
IN (1) IN2014MN02356A (fr)
JO (1) JO3221B1 (fr)
LT (1) LT2867218T (fr)
ME (1) ME02655B (fr)
MX (1) MX347476B (fr)
MY (1) MY172860A (fr)
NZ (1) NZ701894A (fr)
PE (1) PE20150185A1 (fr)
PH (1) PH12015500008B1 (fr)
PL (1) PL2867218T3 (fr)
PT (1) PT2867218T (fr)
RS (1) RS55756B1 (fr)
SG (1) SG11201408629QA (fr)
SI (1) SI2867218T1 (fr)
TN (1) TN2014000500A1 (fr)
TW (1) TWI572597B (fr)
WO (1) WO2014004230A1 (fr)
ZA (1) ZA201408631B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
TWI572597B (zh) * 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基-苯甲酸化合物
EP2765128A1 (fr) * 2013-02-07 2014-08-13 Almirall, S.A. Benzamides substitués présentant une activité vis-à-vis de récepteurs EP4
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫-1h-異喹啉化合物
LT3083554T (lt) 2013-12-17 2019-05-10 Eli Lilly & Company Dimetilbenzoinės rūgšties junginiai
CN107074773A (zh) 2014-09-09 2017-08-18 拜耳制药股份公司 取代的n,2‑二芳基喹啉‑4‑甲酰胺及其用途
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
PE20191616A1 (es) * 2017-04-10 2019-11-05 Bayer Ag N-ariletil-2-arilquinolina-4-carboxamidas sustituidas y su uso
TWI770157B (zh) * 2017-04-10 2022-07-11 德商拜耳廠股份有限公司 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途
CA3060394A1 (fr) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Derives de pyrimidine utilises en tant que modulateurs des recepteurs des pge2
AR111807A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de benzofurano y benzotiofeno como moduladores del receptor pge2
UA125123C2 (uk) 2017-05-18 2022-01-12 Ідорсія Фармасьютікалз Лтд Фенільні похідні як модулятори pge2 рецепторів
JP7065117B2 (ja) 2017-05-18 2022-05-11 イドーシア ファーマシューティカルズ リミテッド N-置換インドール誘導体
AR111874A1 (es) 2017-05-18 2019-08-28 Idorsia Pharmaceuticals Ltd Derivados de pirimidina
TW202228674A (zh) 2020-11-13 2022-08-01 日商小野藥品工業股份有限公司 藉由併用ep4拮抗藥與免疫檢查點抑制物質而進行之癌症治療

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270615B (it) 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina
JP2000355551A (ja) * 1999-06-15 2000-12-26 Nikken Chem Co Ltd 医薬組成物
DK1664016T3 (da) 2003-09-22 2009-02-23 Euro Celtique Sa Terapeutiske midler, der er anvendelige til behandling af smerter
EP1723132A1 (fr) 2004-02-12 2006-11-22 Asterand Uk Limited Agonistes des recepteurs ep sb 2 /sb
JP5183628B2 (ja) * 2006-06-12 2013-04-17 メルク カナダ インコーポレイテッド Ep4受容体リガンドとしてのインドリンアミド誘導体
EP2141147A1 (fr) * 2007-03-26 2010-01-06 Astellas Pharma Inc. Dérivé de l'ornithine
WO2012004293A2 (fr) 2010-07-08 2012-01-12 Bayer Cropscience Ag Associations de substances actives insecticides et fongicides
CA2831978A1 (fr) 2011-03-03 2012-09-07 Universitat Des Saarlandes Derives biaryle en tant qu'inhibiteurs selectifs de la 17beta-hydroxysteroide deshydrogenase de type 2
TWI572597B (zh) * 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基-苯甲酸化合物

Also Published As

Publication number Publication date
HK1203936A1 (en) 2015-11-06
JP2015522589A (ja) 2015-08-06
GT201400289A (es) 2015-05-28
IN2014MN02356A (fr) 2015-08-14
PL2867218T3 (pl) 2017-07-31
DOP2014000286A (es) 2015-01-31
AU2013280779A1 (en) 2014-11-27
CN104334540A (zh) 2015-02-04
MX347476B (es) 2017-04-27
EA201492140A1 (ru) 2015-10-30
CA2875572C (fr) 2016-03-22
EP2867218A1 (fr) 2015-05-06
ZA201408631B (en) 2017-04-26
AP2014008165A0 (en) 2014-12-31
PE20150185A1 (es) 2015-02-13
US20140005222A1 (en) 2014-01-02
CA2875572A1 (fr) 2014-01-03
AP4063A (en) 2017-03-09
KR101634032B1 (ko) 2016-06-27
SG11201408629QA (en) 2015-01-29
SI2867218T1 (sl) 2017-04-26
US8933098B2 (en) 2015-01-13
ES2623099T3 (es) 2017-07-10
MY172860A (en) 2019-12-12
CN104334540B (zh) 2016-03-16
IL236218A (en) 2017-12-31
CR20140554A (es) 2015-02-04
WO2014004230A1 (fr) 2014-01-03
CL2014003537A1 (es) 2015-04-24
PT2867218T (pt) 2017-04-19
US20140094491A1 (en) 2014-04-03
AR091431A1 (es) 2015-02-04
MX2014015952A (es) 2015-07-17
AU2013280779B2 (en) 2015-09-10
IL236218A0 (en) 2015-02-01
JP6114824B2 (ja) 2017-04-12
NZ701894A (en) 2016-09-30
KR20150013335A (ko) 2015-02-04
JO3221B1 (ar) 2018-03-08
CO7160064A2 (es) 2015-01-15
TW201410665A (zh) 2014-03-16
PH12015500008A1 (en) 2015-03-02
LT2867218T (lt) 2017-04-25
CY1118830T1 (el) 2018-01-10
TWI572597B (zh) 2017-03-01
RS55756B1 (sr) 2017-07-31
ME02655B (fr) 2017-06-20
EP2867218B1 (fr) 2017-02-22
US8642768B2 (en) 2014-02-04
EA025531B1 (ru) 2017-01-30
PH12015500008B1 (en) 2015-03-02
HUE032398T2 (en) 2017-09-28
HRP20170540T1 (hr) 2017-06-16
BR112014029551A2 (pt) 2017-06-27
DK2867218T3 (en) 2017-05-01

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