TN2011000291A1 - Purine compounds - Google Patents

Purine compounds

Info

Publication number
TN2011000291A1
TN2011000291A1 TN2011000291A TN2011000291A TN2011000291A1 TN 2011000291 A1 TN2011000291 A1 TN 2011000291A1 TN 2011000291 A TN2011000291 A TN 2011000291A TN 2011000291 A TN2011000291 A TN 2011000291A TN 2011000291 A1 TN2011000291 A1 TN 2011000291A1
Authority
TN
Tunisia
Prior art keywords
purine compounds
purine
compounds
pain
compound
Prior art date
Application number
TN2011000291A
Other languages
English (en)
Inventor
Peter Charles Astles
Rossella Guidetti
Sean Patrick Hollinshead
Michael Wade Tidwell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TN2011000291A1 publication Critical patent/TN2011000291A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
TN2011000291A 2008-12-18 2011-06-09 Purine compounds TN2011000291A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13858908P 2008-12-18 2008-12-18
PCT/US2009/067249 WO2010080306A1 (fr) 2008-12-18 2009-12-09 Composés purines

Publications (1)

Publication Number Publication Date
TN2011000291A1 true TN2011000291A1 (en) 2012-12-17

Family

ID=41719189

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2011000291A TN2011000291A1 (en) 2008-12-18 2011-06-09 Purine compounds

Country Status (29)

Country Link
US (1) US8252798B2 (fr)
EP (1) EP2379555B1 (fr)
JP (1) JP5559812B2 (fr)
KR (1) KR101319630B1 (fr)
CN (1) CN102256977B (fr)
AR (1) AR075104A1 (fr)
AU (1) AU2009335997B2 (fr)
BR (1) BRPI0923195A2 (fr)
CA (1) CA2746740C (fr)
CL (1) CL2011001464A1 (fr)
CO (1) CO6390101A2 (fr)
CR (1) CR20110340A (fr)
DO (1) DOP2011000196A (fr)
EA (1) EA018386B1 (fr)
EC (1) ECSP11011151A (fr)
ES (1) ES2536880T3 (fr)
HN (1) HN2011001700A (fr)
IL (1) IL213167A (fr)
MA (1) MA32904B1 (fr)
MX (1) MX2011006442A (fr)
NZ (1) NZ593088A (fr)
PA (1) PA8851501A1 (fr)
PE (1) PE20110999A1 (fr)
SG (1) SG172253A1 (fr)
TN (1) TN2011000291A1 (fr)
TW (1) TWI376378B (fr)
UA (1) UA104010C2 (fr)
WO (1) WO2010080306A1 (fr)
ZA (1) ZA201103943B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2665277T3 (es) * 2009-03-13 2018-04-25 Katholieke Universiteit Leuven K.U. Leuven R&D Análogos de purina y su uso como agentes inmunosupresores
EP4036082A1 (fr) 2009-08-28 2022-08-03 Arena Pharmaceuticals, Inc. Modulateurs du récepteur cannabinoïde
EP2547338A2 (fr) * 2010-03-17 2013-01-23 F. Hoffmann-La Roche AG Composés d'imidazopyridine, compositions et procédés d'utilisation
WO2011123482A1 (fr) * 2010-03-31 2011-10-06 Eli Lilly And Company Composés de purine utilisés comme agonistes de cb2
AR080711A1 (es) * 2010-03-31 2012-05-02 Lilly Co Eli Compuesto de piperazin-purina composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento o prevencion del dolor
BR112013006016A2 (pt) 2010-09-15 2016-06-07 Hoffmann La Roche compostos de azabenzotiazol, composições e métodos de uso
WO2012066061A1 (fr) 2010-11-19 2012-05-24 F. Hoffmann-La Roche Ag Pyrazolopyridines, et pyrazolopyridines et leur utilisation en tant qu'inhibiteurs de tyk2
CN109970708B (zh) 2011-02-25 2022-06-21 艾尼纳制药公司 ***素受体调节剂
EA035989B1 (ru) 2011-02-25 2020-09-09 Арена Фармасьютикалз, Инк. Кристаллические формы и способы получения модуляторов каннабиноидного рецептора
WO2012116277A1 (fr) 2011-02-25 2012-08-30 Arena Pharmaceuticals, Inc. Modulateurs du récepteur cannabinoïde
CA2845409A1 (fr) * 2011-09-20 2013-03-28 Yingjie Lai Compose imidazopyridine, compositions et procedes d'utilisation
US9067943B2 (en) * 2011-11-25 2015-06-30 Hoffmann-La Roche Inc. [1,2,3]triazolo[4,5-D]pyrimidine derivatives
MX2015002038A (es) * 2012-08-16 2016-01-22 Janssen Pharmaceutica Nv Pirazoles sustituidos como bloqueadores del canal de calcio tipo n.
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors
EP2991988B1 (fr) * 2013-05-02 2017-05-31 F. Hoffmann-La Roche AG Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'agonistes de récepteur cb2
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
WO2017052394A1 (fr) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Composés d'imidazopyridine et leur utilisation comme ligands du récepteur 5-ht6
WO2017184412A1 (fr) 2016-04-18 2017-10-26 Eli Lilly And Company Agoniste cannabinoïde de la purine pour traiter la stéatohépatite non alcoolique et la fibrose
WO2018137176A1 (fr) * 2017-01-25 2018-08-02 Eli Lilly And Company Traitement de la fibrose et de la stéatohépatite non alcoolique
WO2017181317A1 (fr) * 2016-04-18 2017-10-26 Eli Lilly And Company Traitement de la stéatohépatite non alcoolique et de la fibrose
WO2018119076A1 (fr) * 2016-12-21 2018-06-28 Research Triangle Institute Dérivés de diarylpurine présentant une biodisponibilité améliorée
WO2024017227A1 (fr) * 2022-07-21 2024-01-25 长春金赛药业有限责任公司 Composé récepteur cannabinoïde à noyau fusionné substitué et son utilisation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60260579A (ja) * 1984-01-13 1985-12-23 Yoshitomi Pharmaceut Ind Ltd プリン誘導体
IL87149A (en) 1987-07-20 1994-05-30 Merck & Co Inc 6-Piperazinyl derivatives of purine and its 3- and 9-deaza isosteres, their preparation and pharmaceutical compositions containing them
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
GB0003960D0 (en) * 2000-02-18 2000-04-12 Pfizer Ltd Purine derivatives
WO2003022214A2 (fr) 2001-09-06 2003-03-20 Millennium Pharmaceuticals, Inc. Composes a base de piperazine et d'homopiperazine
US20030139427A1 (en) 2002-08-23 2003-07-24 Osi Pharmaceuticals Inc. Bicyclic pyrimidinyl derivatives and methods of use thereof
US7129239B2 (en) * 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
US20040224962A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US20050043327A1 (en) * 2003-08-21 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US20050165029A1 (en) 2004-01-13 2005-07-28 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
KR20070054737A (ko) * 2004-10-22 2007-05-29 화이자 프로덕츠 인코포레이티드 퓨린 화합물의 제조 방법
WO2006128172A2 (fr) 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Procede pour traiter des troubles auto-immuns regules par des lymphocytes b
EP2402334B1 (fr) * 2006-02-02 2016-06-29 Millennium Pharmaceuticals, Inc. Inhibiteurs d'enzymes à activation E1
EP2503890A4 (fr) * 2009-11-24 2013-05-15 Glaxosmithkline Llc Azabenzamidazoles comme inhibiteurs d'acide gras synthase
AR080711A1 (es) * 2010-03-31 2012-05-02 Lilly Co Eli Compuesto de piperazin-purina composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento o prevencion del dolor

Also Published As

Publication number Publication date
IL213167A0 (en) 2011-07-31
CR20110340A (es) 2011-09-16
CA2746740C (fr) 2014-01-14
IL213167A (en) 2013-11-28
NZ593088A (en) 2012-12-21
KR101319630B1 (ko) 2013-10-17
SG172253A1 (en) 2011-07-28
US8252798B2 (en) 2012-08-28
EP2379555A1 (fr) 2011-10-26
KR20110084459A (ko) 2011-07-22
ZA201103943B (en) 2012-11-28
PE20110999A1 (es) 2012-01-16
CA2746740A1 (fr) 2010-07-15
CL2011001464A1 (es) 2012-01-20
CN102256977A (zh) 2011-11-23
EA201170832A1 (ru) 2011-12-30
AR075104A1 (es) 2011-03-09
PA8851501A1 (es) 2010-07-27
MX2011006442A (es) 2011-07-19
ES2536880T3 (es) 2015-05-29
TWI376378B (en) 2012-11-11
BRPI0923195A2 (pt) 2016-02-16
US20100160288A1 (en) 2010-06-24
AU2009335997B2 (en) 2012-05-10
JP2012512873A (ja) 2012-06-07
CN102256977B (zh) 2014-04-16
MA32904B1 (fr) 2011-12-01
WO2010080306A1 (fr) 2010-07-15
AU2009335997A1 (en) 2011-06-23
TW201024296A (en) 2010-07-01
EA018386B1 (ru) 2013-07-30
HN2011001700A (es) 2013-05-06
EP2379555B1 (fr) 2015-02-25
DOP2011000196A (es) 2011-10-31
JP5559812B2 (ja) 2014-07-23
UA104010C2 (en) 2013-12-25
ECSP11011151A (es) 2011-07-29
CO6390101A2 (es) 2012-02-29

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