SV2006002192A - Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie - Google Patents

Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie

Info

Publication number
SV2006002192A
SV2006002192A SV2005002192A SV2005002192A SV2006002192A SV 2006002192 A SV2006002192 A SV 2006002192A SV 2005002192 A SV2005002192 A SV 2005002192A SV 2005002192 A SV2005002192 A SV 2005002192A SV 2006002192 A SV2006002192 A SV 2006002192A
Authority
SV
El Salvador
Prior art keywords
formula
inhibitors
aminoalquil
caseina
cinasa
Prior art date
Application number
SV2005002192A
Other languages
English (en)
Inventor
William Arthur Metz Jr
Fa-Xiang Ding
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of SV2006002192A publication Critical patent/SV2006002192A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

SE DESCRIBE Y REIVINDICA COMPUESTOS DE FORMULA (I) Y FORMULA (II) (VER FORMULA) COMO INHIBIDORES DE LA CASEINA IE HUMANA, Y METODOS DE USO DE DICHOS COMPUESTOS DE FORMULA (I) Y FORMULA (II) PARA EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL INCLUYENDO TRASTORNOS DEL ESTADO DE ANIMO Y TRASTORNOS DEL SUEÑO. TAMBIEN SE DESCRIBEN Y REIVINDICAN COMPOSICIONES FARMACEUTICAS QUE COMPRENDE COMPUESTOS DE FORMULA (I) O FORMULA (II) .
SV2005002192A 2004-08-19 2005-08-10 Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie SV2006002192A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60338004P 2004-08-19 2004-08-19

Publications (1)

Publication Number Publication Date
SV2006002192A true SV2006002192A (es) 2006-06-28

Family

ID=35311279

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2005002192A SV2006002192A (es) 2004-08-19 2005-08-10 Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie

Country Status (27)

Country Link
US (2) US7629376B2 (es)
EP (1) EP1794122B1 (es)
JP (1) JP4843608B2 (es)
KR (2) KR20070043012A (es)
CN (1) CN101006055B (es)
AR (1) AR050919A1 (es)
AT (1) ATE508112T1 (es)
AU (1) AU2005277523B2 (es)
BR (1) BRPI0514380A (es)
CA (1) CA2577667C (es)
DE (1) DE602005027858D1 (es)
GT (1) GT200500214A (es)
HK (1) HK1105196A1 (es)
IL (1) IL181156A (es)
JO (1) JO2724B1 (es)
MA (1) MA28863B1 (es)
MX (1) MX2007001382A (es)
NO (1) NO20071466L (es)
NZ (1) NZ552800A (es)
PA (1) PA8642901A1 (es)
PE (1) PE20060498A1 (es)
RU (1) RU2369599C2 (es)
SV (1) SV2006002192A (es)
TW (1) TWI357897B (es)
UY (1) UY29078A1 (es)
WO (1) WO2006023467A1 (es)
ZA (1) ZA200700651B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092660A1 (ja) * 2009-02-12 2010-08-19 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
KR20120044281A (ko) * 2009-04-17 2012-05-07 사일린 파마슈티칼스, 인크 단백질 키나제 ｃｋ2 활성과 관련된 장애의 치료 방법
UA116541C2 (uk) 2012-06-27 2018-04-10 4Ск Діскавері Гмбх Біфтордіоксаланамінобензімідазольні інгібітори кінази для лікування злоякісного новоутворення, аутоімунного запалення і порушень цнс
CN111757879A (zh) 2018-01-29 2020-10-09 卡地拉健康护理有限公司 用作抗菌剂的杂环化合物
WO2022006377A2 (en) * 2020-07-02 2022-01-06 Mbq Pharma Heterocyclic inhibitors of rho gtpases for the treatment of disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296471A (en) 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
WO2000075669A1 (en) 1999-06-08 2000-12-14 Aventis Pharmaceuticals Inc. Screening methods for altering circadian rhythm proteins
AU2003261415C1 (en) * 2002-08-09 2010-01-14 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
WO2005061498A1 (en) * 2003-12-11 2005-07-07 Aventis Pharmaceuticals Inc. Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon

Also Published As

Publication number Publication date
US20080027124A1 (en) 2008-01-31
US7629376B2 (en) 2009-12-08
NZ552800A (en) 2010-11-26
KR20070043012A (ko) 2007-04-24
AU2005277523B2 (en) 2011-09-29
EP1794122B1 (en) 2011-05-04
JP2008510017A (ja) 2008-04-03
DE602005027858D1 (de) 2011-06-16
ZA200700651B (en) 2008-09-25
RU2369599C2 (ru) 2009-10-10
TWI357897B (en) 2012-02-11
JP4843608B2 (ja) 2011-12-21
WO2006023467A1 (en) 2006-03-02
CA2577667C (en) 2011-01-04
RU2007109783A (ru) 2008-09-27
IL181156A0 (en) 2007-07-04
US7923466B2 (en) 2011-04-12
HK1105196A1 (en) 2008-02-06
KR20130038409A (ko) 2013-04-17
TW200621711A (en) 2006-07-01
BRPI0514380A (pt) 2008-06-10
GT200500214A (es) 2006-03-27
IL181156A (en) 2011-09-27
EP1794122A1 (en) 2007-06-13
PE20060498A1 (es) 2006-07-10
CN101006055A (zh) 2007-07-25
US20090082340A1 (en) 2009-03-26
CN101006055B (zh) 2011-06-22
MX2007001382A (es) 2007-04-19
MA28863B1 (fr) 2007-09-03
AU2005277523A1 (en) 2006-03-02
CA2577667A1 (en) 2006-03-02
PA8642901A1 (es) 2006-05-16
ATE508112T1 (de) 2011-05-15
JO2724B1 (en) 2013-09-15
NO20071466L (no) 2007-04-19
AR050919A1 (es) 2006-12-06
UY29078A1 (es) 2006-03-31

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