SU743580A3 - Method of producing bis-(2-aminocyclopentene-1-yl-1 thyocarbonyl) disulfides - Google Patents
Method of producing bis-(2-aminocyclopentene-1-yl-1 thyocarbonyl) disulfides Download PDFInfo
- Publication number
- SU743580A3 SU743580A3 SU772559902A SU2559902A SU743580A3 SU 743580 A3 SU743580 A3 SU 743580A3 SU 772559902 A SU772559902 A SU 772559902A SU 2559902 A SU2559902 A SU 2559902A SU 743580 A3 SU743580 A3 SU 743580A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- carbon atoms
- ene
- general formula
- disulfides
- group
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
1one
Изобретение относитс к способу получени 2-аминоциклопент-1-ен-1-тиокарбонилдисульфидов общей формулы IThis invention relates to a process for the preparation of 2-aminocyclopent-1-ene-1-thiocarbonyl disulfides of the general formula I
NHHNHH
HHRHhr
C-S-S-C S SC-S-S S S
хуhu
где R - алкил-С -С, незамещенный или замещенный гидроксильной группой , низшей алкоксигруппой, карбоксильной и/или аминогруппой, алкенил-Cg -Cj, , циклоалкил-С5 -С, , которые обладают биологической активностью и могут поэтому найти применение в медицине.where R is alkyl-C-C, unsubstituted or substituted by hydroxyl group, lower alkoxy group, carboxyl and / or amino group, alkenyl-Cg-Cj,, cycloalkyl-C5-C, which have biological activity and can therefore be used in medicine.
Известен способ получени тиурамдисулвфидов , заключающийс в окислении дитиокарбаминовых кислот известными методами, например, с помощью перекиси водррола или перманганата натри Щ .A known method for the preparation of thiuram disulphides, which involves the oxidation of dithiocarbamic acids by known methods, for example, with the aid of aqdrol peroxide or sodium permanganate.
Цель изобретени - разработка способа получени новых биологически активных 2-аминоциклопент-1-ен-1-тиокарбонилдисульфидов овщей формулы 1, обладающих высокой биологической активностью.The purpose of the invention is to develop a method for the preparation of novel biologically active 2-aminocyclopent-1-ene-1-thiocarbonyl disulfides of formula 1 with high biological activity.
Это достигаетс тем, что 2-аминоциклопент-1-ен-1-тиокарбонилди2This is achieved by the fact that 2-aminocyclopent-1-ene-1-thiocarbonyldi2
сульфидов 2-аминоциклопент-1-ен-1дитиокарбоновую кислоту общей формулы I I :sulfides 2-aminocyclopent-1-ene-1dithiocarboxylic acid of the general formula I I:
NHHNHH
CSHCSH
где R - имеет указанные значени , окисл ют с последук цим выделениемwhere R - has the indicated values, is oxidized with the subsequent release
10 целевого продукта в свободном виде.10 target product in free form.
Окисление провод т с помощью окислителей, обычно использующихс дл получени дисульфидов, например, перекиси водорода или перманганатаThe oxidation is carried out using oxidizing agents commonly used to produce disulfides, such as hydrogen peroxide or permanganate.
16 кали . В качестве растворител предпочтительно используют воду.16 potassium. Water is preferably used as a solvent.
Пример 1. 2-Аллиламиноциклопент-1-ен-1-тиокарбонилдисульфид . 2,98 г (0,015 мол ) 2-аллиламиноаО циклопент-1-ен-1-дитиокарбоновой кислоты суспендируют в 30 мл воды, затем добавл ют 6 г (0,015 мол ) гидроокиси натри в виде 10%-ного раствора едкого натра и смесь встр хи-,Example 1. 2-Allylaminocyclopent-1-ene-1-thiocarbonyl disulfide. 2.98 g (0.015 mol) of 2-allylamino-O cyclopent-1-ene-1-dithiocarboxylic acid is suspended in 30 ml of water, then 6 g (0.015 mol) of sodium hydroxide is added in the form of a 10% sodium hydroxide solution and mixed in him-
25 вают 10 мин. При комнатной температуре добавл ют смесь 3 мл воды, 0,9 г (0,0075 мол ) концентрированной серной кислоты и 0,9 г (0,0075 мол ) 30%-ной перекиси водорода и смесь встр хивгиот 3 ч. Вы25 is 10 minutes. At room temperature, add a mixture of 3 ml of water, 0.9 g (0.0075 mol) of concentrated sulfuric acid and 0.9 g (0.0075 mol) of 30% hydrogen peroxide and a mixture of shakes 3 hours. You
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU76RI610A HU175526B (en) | 1976-12-30 | 1976-12-30 | Process for producing 2-amino-cyclopent-1-2n2-1-dithiocarboxylic acid -disulfides |
Publications (1)
Publication Number | Publication Date |
---|---|
SU743580A3 true SU743580A3 (en) | 1980-06-25 |
Family
ID=11001014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU772559902A SU743580A3 (en) | 1976-12-30 | 1977-12-28 | Method of producing bis-(2-aminocyclopentene-1-yl-1 thyocarbonyl) disulfides |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS5384949A (en) |
AR (1) | AR216308A1 (en) |
AT (1) | AT351501B (en) |
AU (1) | AU516353B2 (en) |
BE (1) | BE862408A (en) |
CH (1) | CH631701A5 (en) |
DE (1) | DE2758809A1 (en) |
ES (1) | ES465567A1 (en) |
FI (1) | FI66595C (en) |
FR (1) | FR2376132A1 (en) |
GB (1) | GB1582716A (en) |
HU (1) | HU175526B (en) |
IL (1) | IL53646A (en) |
IN (1) | IN146470B (en) |
NL (1) | NL7714514A (en) |
NO (1) | NO145237C (en) |
PT (1) | PT67482B (en) |
SE (1) | SE7714526L (en) |
SU (1) | SU743580A3 (en) |
YU (1) | YU309677A (en) |
ZA (1) | ZA777573B (en) |
-
1976
- 1976-12-30 HU HU76RI610A patent/HU175526B/en unknown
-
1977
- 1977-12-19 IL IL53646A patent/IL53646A/en unknown
- 1977-12-20 ZA ZA00777573A patent/ZA777573B/en unknown
- 1977-12-20 AT AT912077A patent/AT351501B/en not_active IP Right Cessation
- 1977-12-20 SE SE7714526A patent/SE7714526L/en not_active Application Discontinuation
- 1977-12-21 CH CH1582477A patent/CH631701A5/en not_active IP Right Cessation
- 1977-12-23 AU AU31979/77A patent/AU516353B2/en not_active Expired
- 1977-12-26 FR FR7739183A patent/FR2376132A1/en active Granted
- 1977-12-27 IN IN1772/CAL/77A patent/IN146470B/en unknown
- 1977-12-27 YU YU03096/77A patent/YU309677A/en unknown
- 1977-12-28 SU SU772559902A patent/SU743580A3/en active
- 1977-12-28 BE BE183912A patent/BE862408A/en not_active IP Right Cessation
- 1977-12-29 PT PT67482A patent/PT67482B/en unknown
- 1977-12-29 GB GB54173/77A patent/GB1582716A/en not_active Expired
- 1977-12-29 NL NL7714514A patent/NL7714514A/en not_active Application Discontinuation
- 1977-12-29 AR AR270573A patent/AR216308A1/en active
- 1977-12-29 JP JP15853077A patent/JPS5384949A/en active Pending
- 1977-12-29 NO NO774502A patent/NO145237C/en unknown
- 1977-12-29 ES ES465567A patent/ES465567A1/en not_active Expired
- 1977-12-29 FI FI773967A patent/FI66595C/en not_active IP Right Cessation
- 1977-12-30 DE DE19772758809 patent/DE2758809A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ES465567A1 (en) | 1979-01-01 |
NL7714514A (en) | 1978-07-04 |
NO145237C (en) | 1982-02-10 |
NO145237B (en) | 1981-11-02 |
NO774502L (en) | 1978-07-03 |
CH631701A5 (en) | 1982-08-31 |
FI66595C (en) | 1984-11-12 |
HU175526B (en) | 1980-08-28 |
AU3197977A (en) | 1979-06-28 |
AU516353B2 (en) | 1981-05-28 |
DE2758809A1 (en) | 1978-07-06 |
GB1582716A (en) | 1981-01-14 |
AR216308A1 (en) | 1979-12-14 |
IL53646A (en) | 1982-03-31 |
PT67482A (en) | 1978-01-01 |
AT351501B (en) | 1979-07-25 |
BE862408A (en) | 1978-04-14 |
FR2376132B1 (en) | 1979-10-19 |
FI66595B (en) | 1984-07-31 |
FI773967A (en) | 1978-07-01 |
IL53646A0 (en) | 1978-03-10 |
ZA777573B (en) | 1978-10-25 |
ATA912077A (en) | 1979-01-15 |
IN146470B (en) | 1979-06-09 |
FR2376132A1 (en) | 1978-07-28 |
YU309677A (en) | 1983-01-21 |
JPS5384949A (en) | 1978-07-26 |
SE7714526L (en) | 1978-07-01 |
PT67482B (en) | 1979-05-30 |
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