SU505362A3 - Способ получени оксипиримидинов - Google Patents

Способ получени оксипиримидинов

Info

Publication number
SU505362A3
SU505362A3 SU2008490A SU2008490A SU505362A3 SU 505362 A3 SU505362 A3 SU 505362A3 SU 2008490 A SU2008490 A SU 2008490A SU 2008490 A SU2008490 A SU 2008490A SU 505362 A3 SU505362 A3 SU 505362A3
Authority
SU
USSR - Soviet Union
Prior art keywords
oxypyrimidines
producing
sodium
atom
general formula
Prior art date
Application number
SU2008490A
Other languages
English (en)
Inventor
Эндрю Липински(Сша) Христофер
Джеррит Стам(Сша) Джон
Джорж Дианджемк(Сша) Джеральд
Юрген Эрнест Гесс(Фрг) Ганс
Original Assignee
Пфайзер Инк (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк (Фирма) filed Critical Пфайзер Инк (Фирма)
Application granted granted Critical
Publication of SU505362A3 publication Critical patent/SU505362A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56One oxygen atom and one sulfur atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Description

(54) СПОСОБ ПОЛУЧЕНИЯ ОКСИПИРИМИДИНОВ
где R, - атом водорода, атом rajioieiia, алкилрадикал с 1-3 атомами углерода, метокси или карбоксигруппа;
RI атом водорода, атом хлора, метилрадикал ,
или их солей, заключаетс  в том, что натриевую соль соединени  об1пей формулы ( II ) г
О I
-0-С-С-ОН,
и снон
Соединени  общей формулы (II) пoJjyчaю при взаимодействии фенола или замещенного фе-.юла с эти лх лор ацетатом в присутствии этилата штри  с образованием феноксиацетата, который реашрует с металлическим натрием или гидридом натри  и метилформиатом в среде этилового эфира с образовашем натриевой соли этилфеноксиоксиакрилата .
Полученный акрилат затем нагревают с тиомочевиной в присутствии метилата натри  в среде этанола. Продукт подкисл ют, отфильтроньшают и пepeкpиcтaJUlизoвbшaют из смеси растворн1слей хлороформ (эшловый спирт) - уксусна  кислотас образованием фенокситиоурацила.
SU2008490A 1971-10-29 1974-03-26 Способ получени оксипиримидинов SU505362A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19400671A 1971-10-29 1971-10-29

Publications (1)

Publication Number Publication Date
SU505362A3 true SU505362A3 (ru) 1976-02-28

Family

ID=22715935

Family Applications (2)

Application Number Title Priority Date Filing Date
SU1839308A SU498908A3 (ru) 1971-10-29 1972-10-13 Способ получени производных пиримидинона
SU2008490A SU505362A3 (ru) 1971-10-29 1974-03-26 Способ получени оксипиримидинов

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU1839308A SU498908A3 (ru) 1971-10-29 1972-10-13 Способ получени производных пиримидинона

Country Status (25)

Country Link
JP (2) JPS5337870B2 (ru)
AR (2) AR198798A1 (ru)
AT (2) AT320656B (ru)
AU (1) AU467600B2 (ru)
BE (1) BE790125A (ru)
CA (1) CA980778A (ru)
CH (2) CH555832A (ru)
DE (3) DE2264657C2 (ru)
DK (1) DK131465B (ru)
EG (1) EG11013A (ru)
ES (2) ES407730A1 (ru)
FI (1) FI55503C (ru)
FR (1) FR2157865B1 (ru)
GB (2) GB1377308A (ru)
IE (1) IE37043B1 (ru)
IL (2) IL40458A (ru)
LU (1) LU66304A1 (ru)
NL (1) NL166470C (ru)
NO (1) NO136574C (ru)
PH (2) PH10129A (ru)
PL (2) PL84634B1 (ru)
SE (2) SE393376B (ru)
SU (2) SU498908A3 (ru)
YU (2) YU35125B (ru)
ZA (1) ZA727362B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151912U (ru) * 1979-04-17 1980-11-01
JPS5752409Y2 (ru) * 1979-11-05 1982-11-15
DE3222914A1 (de) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPH0655686B2 (ja) * 1988-08-30 1994-07-27 宇部興産株式会社 p−ブロモフェノキシアセトアルデヒドジアルキルアセタール類の製造方法
KR101577554B1 (ko) 2005-08-22 2015-12-14 멜리어 파마슈티칼스 아이, 인코포레이티드 Lyn 키나제 활성의 조절 및 관련된 장애의 치료를 위한 방법 및 제제
US8552184B2 (en) 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
US20130158055A1 (en) 2010-05-28 2013-06-20 Andrew G. Reaume Prevention Of Pancreatic Beta Cell Degeneration
CA3059432A1 (en) 2017-04-10 2018-10-18 Melior Pharmaceuticals I, Inc. Compositions comprising a lyn kinase activator and a trpms agonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913462A (en) * 1959-11-17 Eahl h
GB951432A (en) * 1959-03-17 1964-03-04 Wellcome Found Pyrimidine derivatives and the manufacture thereof

Also Published As

Publication number Publication date
ES407730A1 (es) 1976-01-16
SE397090B (sv) 1977-10-17
ES436624A1 (es) 1977-02-01
DK131465B (da) 1975-07-21
PH11594A (en) 1978-03-31
PH10129A (en) 1976-09-02
DE2264374B2 (de) 1980-08-07
NL166470C (nl) 1981-08-17
FI55503C (fi) 1979-08-10
SE7505279L (sv) 1975-05-06
ZA727362B (en) 1973-11-28
CA980778A (en) 1975-12-30
PL84634B1 (ru) 1976-04-30
IL40458A0 (en) 1972-11-28
DK131465C (ru) 1975-12-08
GB1377720A (en) 1974-12-18
DE2248741B2 (de) 1974-11-14
YU255172A (en) 1980-03-15
IL48790A (en) 1976-05-31
CH555832A (fr) 1974-11-15
PL89852B1 (ru) 1976-12-31
DE2264657C2 (de) 1982-09-16
JPS5422995B2 (ru) 1979-08-10
IL48790A0 (en) 1976-03-31
DE2248741A1 (de) 1973-05-03
IE37043L (en) 1973-04-29
DE2264374A1 (de) 1973-05-24
CH549579A (fr) 1974-05-31
FR2157865B1 (ru) 1975-10-31
FI55503B (fi) 1979-04-30
AT320656B (de) 1975-02-25
EG11013A (en) 1976-11-30
NO136574B (ru) 1977-06-20
YU35125B (en) 1980-09-25
JPS4852780A (ru) 1973-07-24
GB1377308A (en) 1974-12-11
SU498908A3 (ru) 1976-01-05
IE37043B1 (en) 1977-04-27
AU4722872A (en) 1974-04-04
SE393376B (sv) 1977-05-09
DE2264374C3 (de) 1981-07-23
LU66304A1 (ru) 1973-05-03
AR196263A1 (es) 1973-12-10
NO136574C (no) 1977-09-28
FR2157865A1 (ru) 1973-06-08
IL40458A (en) 1976-05-31
AR198798A1 (es) 1974-07-24
JPS5337870B2 (ru) 1978-10-12
DE2248741C3 (de) 1975-06-26
NL7213959A (ru) 1973-05-02
NL166470B (nl) 1981-03-16
YU99179A (en) 1981-08-31
AU467600B2 (en) 1975-12-04
DE2264657A1 (de) 1974-06-20
AT321308B (de) 1975-03-25
YU36295B (en) 1982-06-18
BE790125A (fr) 1973-04-16
JPS53116386A (en) 1978-10-11

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