ES456279A1 - Un procedimiento para preparar compuestos de cetofosfonato. - Google Patents
Un procedimiento para preparar compuestos de cetofosfonato.Info
- Publication number
- ES456279A1 ES456279A1 ES456279A ES456279A ES456279A1 ES 456279 A1 ES456279 A1 ES 456279A1 ES 456279 A ES456279 A ES 456279A ES 456279 A ES456279 A ES 456279A ES 456279 A1 ES456279 A1 ES 456279A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- indanyl
- pentanorprostaglandins
- ketophosphonate
- cycloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 1-adamantyl Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000004135 2-norbornyl group Chemical group [H]C1([H])C([H])([H])C2([H])C([H])([H])C1([H])C([H])([H])C2([H])* 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Un procedimiento para preparar compuestos de cetofosfonato de la estructura: (**formula**) en la que A es cicloalcohilo de tres a diez átomos de carbono, 1-adamantilo, 2-norbornilo, 2-(1,2,3,4-tetrahidronaftilo), 2-indanilo o 2-indanilo sustituido en el que dicho sustituyente en halógeno, trifluorometilo, alcohilo de 1 a 4 átomos de carbono o alcoxi de 1 a 4 átomos de carbono; n es un número entero de 0 a 05; caracterizado por hacer reaccionar un éster alcohilo (de 1 a 4 átomos de carbono).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30475072A | 1972-11-08 | 1972-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES456279A1 true ES456279A1 (es) | 1978-11-01 |
Family
ID=23177829
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES420386A Expired ES420386A1 (es) | 1972-11-08 | 1973-11-09 | Un procedimiento para preparar un pentanorprostaglandinas. |
ES444398A Expired ES444398A1 (es) | 1972-11-08 | 1976-01-16 | Un procedimiento para preparar compuestos intermedios de o- mega-pentanorprostaglandinas. |
ES456279A Expired ES456279A1 (es) | 1972-11-08 | 1977-11-25 | Un procedimiento para preparar compuestos de cetofosfonato. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES420386A Expired ES420386A1 (es) | 1972-11-08 | 1973-11-09 | Un procedimiento para preparar un pentanorprostaglandinas. |
ES444398A Expired ES444398A1 (es) | 1972-11-08 | 1976-01-16 | Un procedimiento para preparar compuestos intermedios de o- mega-pentanorprostaglandinas. |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS5714347B2 (es) |
AT (1) | AT345999B (es) |
BE (1) | BE807046A (es) |
CA (1) | CA1033727A (es) |
CH (1) | CH593930A5 (es) |
DE (1) | DE2355731C3 (es) |
DK (1) | DK143499C (es) |
ES (3) | ES420386A1 (es) |
FI (1) | FI58912C (es) |
FR (3) | FR2205338B1 (es) |
GB (1) | GB1456838A (es) |
IE (1) | IE40043B1 (es) |
IL (2) | IL43571A (es) |
IN (1) | IN139265B (es) |
NL (1) | NL7315307A (es) |
NO (2) | NO143663C (es) |
PH (2) | PH13261A (es) |
SE (4) | SE412229B (es) |
SU (2) | SU667131A3 (es) |
ZA (1) | ZA738595B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1431561A (en) * | 1973-01-31 | 1976-04-07 | Ici Ltd | Cyclopentane derivatives |
US3929862A (en) * | 1974-01-08 | 1975-12-30 | Upjohn Co | Substituted tolylesters of PGF{HD 2{B {60 |
JPS5823393B2 (ja) * | 1974-03-14 | 1983-05-14 | オノヤクヒンコウギヨウ カブシキガイシヤ | プロスタグランジンルイジカゴウブツ ノ セイゾウホウホウ |
US4028396A (en) * | 1975-07-02 | 1977-06-07 | American Cyanamid Company | 16,16-Spirocycloalkyl prostaglandin derivatives |
NZ183136A (en) * | 1976-02-11 | 1978-11-13 | Miles Lab | Monospiroalkyl derivatives of prostaclandis and pharmaceutical compositions |
US4074063A (en) * | 1976-02-11 | 1978-02-14 | Miles Laboratories, Inc. | Bicycloalkyl derivatives of prostaglandins |
US4404372A (en) * | 1977-06-13 | 1983-09-13 | Pfizer Inc. | 15-Substituted-ω-pentanorprostaglandin derivatives |
DE2753995A1 (de) * | 1977-12-03 | 1979-06-07 | Bayer Ag | Neue bicycloalkenyl-prostaglandine und verfahren zu ihrer herstellung |
EP1021402B1 (en) * | 1997-09-09 | 2005-11-23 | Duke University | Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists |
PL339212A1 (en) * | 1997-09-09 | 2000-12-04 | Procter & Gamble | Aromatic c16-c20-substituted tetrahydroprostaglandines useful as fp agonists |
SK3382000A3 (en) * | 1997-09-09 | 2000-10-09 | Procter & Gamble | A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders |
JP4834224B2 (ja) * | 1999-03-05 | 2011-12-14 | デューク ユニバーシティ | C16不飽和fp−選択的プロスタグランジン類縁体 |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
ES2326558T3 (es) * | 2007-11-28 | 2009-10-14 | Bauer Maschinen Gmbh | Torno. |
US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US20230097470A1 (en) * | 2021-08-23 | 2023-03-30 | Chirogate International Inc. | Processes and intermediates for the preparations of carboprost and carboprost tromethamine, and carboprost tromethamine prepared therefrom |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4864073A (es) * | 1971-04-30 | 1973-09-05 |
-
1973
- 1973-11-05 IL IL43571A patent/IL43571A/en unknown
- 1973-11-05 IL IL50310A patent/IL50310A/en unknown
- 1973-11-06 SE SE7315074A patent/SE412229B/xx unknown
- 1973-11-08 CH CH1570773A patent/CH593930A5/xx not_active IP Right Cessation
- 1973-11-08 IE IE2014/73A patent/IE40043B1/xx unknown
- 1973-11-08 DE DE2355731A patent/DE2355731C3/de not_active Expired
- 1973-11-08 BE BE1005488A patent/BE807046A/xx unknown
- 1973-11-08 ZA ZA738595A patent/ZA738595B/xx unknown
- 1973-11-08 AT AT941073A patent/AT345999B/de not_active IP Right Cessation
- 1973-11-08 FR FR7339758A patent/FR2205338B1/fr not_active Expired
- 1973-11-08 FI FI3455/73A patent/FI58912C/fi active
- 1973-11-08 NO NO4294/73A patent/NO143663C/no unknown
- 1973-11-08 NL NL7315307A patent/NL7315307A/xx not_active Application Discontinuation
- 1973-11-08 PH PH15197A patent/PH13261A/en unknown
- 1973-11-08 GB GB5199773A patent/GB1456838A/en not_active Expired
- 1973-11-08 CA CA185,366A patent/CA1033727A/en not_active Expired
- 1973-11-08 JP JP12584373A patent/JPS5714347B2/ja not_active Expired
- 1973-11-08 DK DK603373A patent/DK143499C/da active
- 1973-11-09 ES ES420386A patent/ES420386A1/es not_active Expired
- 1973-11-23 IN IN2583/CAL/73A patent/IN139265B/en unknown
- 1973-12-07 SU SU731978255A patent/SU667131A3/ru active
-
1974
- 1974-10-07 NO NO743616A patent/NO144385C/no unknown
-
1975
- 1975-12-23 SU SU752182652A patent/SU704456A3/ru active
-
1976
- 1976-01-16 ES ES444398A patent/ES444398A1/es not_active Expired
- 1976-01-29 FR FR7602433A patent/FR2286147A1/fr active Granted
- 1976-01-29 FR FR7602434A patent/FR2291200A1/fr active Granted
- 1976-05-25 PH PH18469A patent/PH13320A/en unknown
- 1976-11-03 SE SE7612262A patent/SE7612262L/xx not_active Application Discontinuation
- 1976-11-03 SE SE7612261A patent/SE7612261L/xx unknown
-
1977
- 1977-02-10 SE SE7701523A patent/SE417957B/xx unknown
- 1977-11-25 ES ES456279A patent/ES456279A1/es not_active Expired
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