SU1144629A3 - Способ определени креатинина в сыворотке крови - Google Patents

Способ определени креатинина в сыворотке крови Download PDF

Info

Publication number: SU1144629A3
Authority: SU; USSR - Soviet Union
Prior art keywords: creatinine; creatine; sample; blood serum; buffer
Prior art date: 1971-05-05

Application number

SU721777222A

Other languages

English (en)

Russian (ru)

Inventor

Валефельд Меллеринг Аугуст

Бернт Эрих

Грубер Вольфганг

Ульрих Бергмайер Ханс

Original Assignee

Берингер Маннхайм Гмбх (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-05-05

Filing date

1972-04-17

Publication date

1985-03-07

1971-05-05 Priority claimed from DE2122255A external-priority patent/DE2122255C3/de

1972-04-17 Application filed by Берингер Маннхайм Гмбх (Фирма) filed Critical Берингер Маннхайм Гмбх (Фирма)

1985-03-07 Application granted granted Critical

1985-03-07 Publication of SU1144629A3 publication Critical patent/SU1144629A3/ru

Links

DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 title claims abstract description 55
229940109239 creatinine Drugs 0.000 title claims abstract description 28
238000000034 method Methods 0.000 title claims abstract description 22
210000002966 serum Anatomy 0.000 title claims description 6
CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims abstract description 34
229960003624 creatine Drugs 0.000 claims abstract description 17
239000006046 creatine Substances 0.000 claims abstract description 17
230000003247 decreasing effect Effects 0.000 claims abstract 2
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
102000004420 Creatine Kinase Human genes 0.000 description 10
108010042126 Creatine kinase Proteins 0.000 description 10
ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 8
239000000872 buffer Substances 0.000 description 8
238000006243 chemical reaction Methods 0.000 description 7
102000004190 Enzymes Human genes 0.000 description 6
108090000790 Enzymes Proteins 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 6
108090000604 Hydrolases Proteins 0.000 description 5
102000004169 proteins and genes Human genes 0.000 description 5
108090000623 proteins and genes Proteins 0.000 description 5
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 4
BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 3
230000008033 biological extinction Effects 0.000 description 3
239000000203 mixture Substances 0.000 description 3
229950006238 nadide Drugs 0.000 description 3
238000000926 separation method Methods 0.000 description 3
108010077078 Creatinase Proteins 0.000 description 2
239000004471 Glycine Substances 0.000 description 2
102000003855 L-lactate dehydrogenase Human genes 0.000 description 2
108700023483 L-lactate dehydrogenases Proteins 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 2
235000011180 diphosphates Nutrition 0.000 description 2
YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 2
238000005259 measurement Methods 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
DTBNBXWJWCWCIK-UHFFFAOYSA-K phosphonatoenolpyruvate Chemical compound [O-]C(=O)C(=C)OP([O-])([O-])=O DTBNBXWJWCWCIK-UHFFFAOYSA-K 0.000 description 2
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 2
FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
235000011121 sodium hydroxide Nutrition 0.000 description 2
XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 description 1
ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 description 1
ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 1
108010008488 Glycylglycine Proteins 0.000 description 1
102000006746 NADH Dehydrogenase Human genes 0.000 description 1
108010086428 NADH Dehydrogenase Proteins 0.000 description 1
102000013009 Pyruvate Kinase Human genes 0.000 description 1
108020005115 Pyruvate Kinase Proteins 0.000 description 1
108010077895 Sarcosine Proteins 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
230000032683 aging Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
238000001514 detection method Methods 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
229940043257 glycylglycine Drugs 0.000 description 1
239000007999 glycylglycine buffer Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
229930029653 phosphoenolpyruvate Natural products 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
229940075930 picrate Drugs 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
229940043230 sarcosine Drugs 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
210000002700 urine Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

SU721777222A 1971-05-05 1972-04-17 Способ определени креатинина в сыворотке крови SU1144629A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2122255A DE2122255C3 (de)	1971-05-05	1971-05-05	Verfahren zur spezifischen Bestimmung von Creatinin

Publications (1)

Publication Number	Publication Date
SU1144629A3 true SU1144629A3 (ru)	1985-03-07

Family

ID=5806955

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU721777222A SU1144629A3 (ru)	1971-05-05	1972-04-17	Способ определени креатинина в сыворотке крови

Country Status (8)

Country	Link
JP (1)	JPS5443397B1 (de)
DK (1)	DK139769C (de)
FI (1)	FI53367C (de)
HU (1)	HU163672B (de)
IL (1)	IL38918A (de)
IT (1)	IT968190B (de)
SE (1)	SE377723B (de)
SU (1)	SU1144629A3 (de)

1972
- 1972-03-02 IT IT21333/72A patent/IT968190B/it active
- 1972-03-07 IL IL38918A patent/IL38918A/en unknown
- 1972-04-17 SU SU721777222A patent/SU1144629A3/ru active
- 1972-05-04 FI FI1265/72A patent/FI53367C/fi active
- 1972-05-04 DK DK221272A patent/DK139769C/da not_active IP Right Cessation
- 1972-05-04 HU HUBO1370A patent/HU163672B/hu unknown
- 1972-05-04 SE SE7205871A patent/SE377723B/xx unknown
- 1972-05-06 JP JP4495272A patent/JPS5443397B1/ja active Pending

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1. Биохимические методы исследовани в клинике. М., 1969, с. 103105. *

Also Published As

Publication number	Publication date
IL38918A0 (en)	1972-05-30
DK139769B (da)	1979-04-09
IT968190B (it)	1974-03-20
HU163672B (de)	1973-10-27
SE377723B (de)	1975-07-21
FI53367B (de)	1977-12-30
IL38918A (en)	1974-12-31
DK139769C (da)	1979-09-24
FI53367C (fi)	1978-04-10
JPS5443397B1 (de)	1979-12-19

Publication	Publication Date	Title
US6068971A (en)	2000-05-30	Process for determination of ions in fluids by masking of interfering ions
SU1338787A3 (ru)	1987-09-15	Способ определени перекиси водорода при ферментативной реакции
Bell et al.	1960	A colorimetric method for determination of isocitric dehydrogenase
US5384247A (en)	1995-01-24	Determination of sodium ions in fluids
GB1512328A (en)	1978-06-01	Method and reagent for determining the activity of creatinekinase-mb
US4000042A (en)	1976-12-28	Diagnostic reagent for the determination of amylase
Lundin et al.	1978	Sensitive assay of creatine kinase isoenzymes in human serum using M subunit inhibiting antibody and firefly luciferase
IL46545A (en)	1977-06-30	Analytical process for enzymatic determination of substrates in biological Niger
Laursen et al.	1958	A fluorimetric method for measuring the activity in serum of the enzyme glutamic pyruvic transaminase
Scopes	1972	A new enzymic method for inorganic phosphate determination
SU1144629A3 (ru)	1985-03-07	Способ определени креатинина в сыворотке крови
Meiattini et al.	1978	Adenylate kinase inhibition by adenosine 5'-monophosphate and fluoride in the determination of creatine kinase activity.
DK164512B (da)	1992-07-06	Fremgangsmaade til simultan bestemmelse af prokallikrein og den partielle thromboplastintid
US4329425A (en)	1982-05-11	Method for determination of transaminases and relative diagnostic kit
US3335069A (en)	1967-08-08	Composition and method for determining uric acid
CN111057746B (zh)	2023-10-27	一种肌酸激酶同工酶测定试剂盒
US4206280A (en)	1980-06-03	Determination of acid phosphatase
US3591459A (en)	1971-07-06	Method of enzyme determination
US6413733B1 (en)	2002-07-02	Stabilized reagent and method for determining creatine kinase
Wilkinson	1970	Enzyme kinetics and its relevance to enzyme assay.
US3536588A (en)	1970-10-27	Method of enzyme determination
AU662510B2 (en)	1995-09-07	Determination of ions in fluids
JPH07303497A (ja)	1995-11-21	生体成分の測定方法および測定用試薬組成物
AU662516B2 (en)	1995-09-07	Determination of ions in fluids
SU1449588A1 (ru)	1989-01-07	Способ определени активности щелочной фосфатазы