SU1028039A1 - Method of synthesis of rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone - Google Patents

Method of synthesis of rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone

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Publication number
SU1028039A1
SU1028039A1 SU3311816/04A SU3311816A SU1028039A1 SU 1028039 A1 SU1028039 A1 SU 1028039A1 SU 3311816/04 A SU3311816/04 A SU 3311816/04A SU 3311816 A SU3311816 A SU 3311816A SU 1028039 A1 SU1028039 A1 SU 1028039A1
Authority
SU
USSR - Soviet Union
Prior art keywords
rubomycine
hydrochloride
oxyl
hydrazone
chloroform
Prior art date
Application number
SU3311816/04A
Other languages
Russian (ru)
Inventor
А.Б. Шапиро
Л.С. Поваров
В.И. Сускина
Н.М. Эмануэль
Original Assignee
Отделение Института химической физики АН СССР
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Отделение Института химической физики АН СССР filed Critical Отделение Института химической физики АН СССР
Priority to SU3311816/04A priority Critical patent/SU1028039A1/en
Application granted granted Critical
Publication of SU1028039A1 publication Critical patent/SU1028039A1/en

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Abstract

FIELD: organic chemistry, antibiotics. SUBSTANCE: product: rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone of the formula. Product is synthesized from rubomycine hydrochloride in spirituous-chloroform medium. Rubomycine hydrochloride is treated with hydrazine hydrate or anhydrous hydrazine at molar ratio 1: (1.1-1.2), respectively, in medium methanol-chloroform or ethanol-chloroform taken at volume ratio 2: 1, respectively, at 20-40 C followed by interaction of prepared rubomycine hydrazone with 1-oxyl-2,2,6,6-tetramethylpiperidone-4 taken at their molar ratio 1:(2.5-4), respectively. Alternative method: process is carried out in the presence of acetic acid taken at amount 10-25% of rubomycine hydrochloride weight. EFFECT: improved method of synthesis.
SU3311816/04A 1981-06-25 1981-06-25 Method of synthesis of rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone SU1028039A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU3311816/04A SU1028039A1 (en) 1981-06-25 1981-06-25 Method of synthesis of rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU3311816/04A SU1028039A1 (en) 1981-06-25 1981-06-25 Method of synthesis of rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone

Publications (1)

Publication Number Publication Date
SU1028039A1 true SU1028039A1 (en) 1996-08-27

Family

ID=60526263

Family Applications (1)

Application Number Title Priority Date Filing Date
SU3311816/04A SU1028039A1 (en) 1981-06-25 1981-06-25 Method of synthesis of rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone

Country Status (1)

Country Link
SU (1) SU1028039A1 (en)

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