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FIELD: organic chemistry, antibiotics. SUBSTANCE: product: rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone of the formula. Product is synthesized from rubomycine hydrochloride in spirituous-chloroform medium. Rubomycine hydrochloride is treated with hydrazine hydrate or anhydrous hydrazine at molar ratio 1: (1.1-1.2), respectively, in medium methanol-chloroform or ethanol-chloroform taken at volume ratio 2: 1, respectively, at 20-40 C followed by interaction of prepared rubomycine hydrazone with 1-oxyl-2,2,6,6-tetramethylpiperidone-4 taken at their molar ratio 1:(2.5-4), respectively. Alternative method: process is carried out in the presence of acetic acid taken at amount 10-25% of rubomycine hydrochloride weight. EFFECT: improved method of synthesis.
SU3311816/04A1981-06-251981-06-25Method of synthesis of rubomycine hydrochloride 13-(1-oxyl-2,2,6,6-tetramethylpiperylidenyl-4)-hydrazone
SU1028039A1
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