SMT201600220B - Derivati di eterociclile biciclici come inibitori di fgfr chinasi per uso terapeutico - Google Patents
Derivati di eterociclile biciclici come inibitori di fgfr chinasi per uso terapeuticoInfo
- Publication number
- SMT201600220B SMT201600220B SM201600220T SM201600220T SMT201600220B SM T201600220 B SMT201600220 B SM T201600220B SM 201600220 T SM201600220 T SM 201600220T SM 201600220 T SM201600220 T SM 201600220T SM T201600220 B SMT201600220 B SM T201600220B
- Authority
- SM
- San Marino
- Prior art keywords
- chinase
- fgfr
- inhibitors
- derivatives
- therapeutic use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16948709P | 2009-04-15 | 2009-04-15 | |
| GBGB0906472.6A GB0906472D0 (en) | 2009-04-15 | 2009-04-15 | New compounds |
| PCT/GB2010/050617 WO2010119284A1 (en) | 2009-04-15 | 2010-04-15 | Bicyclic heterocyclyl derivatives as fgfr kinase inhibitors for therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600220B true SMT201600220B (it) | 2016-08-31 |
Family
ID=40750627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600220T SMT201600220B (it) | 2009-04-15 | 2016-07-05 | Derivati di eterociclile biciclici come inibitori di fgfr chinasi per uso terapeutico |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8481531B2 (it) |
| EP (1) | EP2419427B1 (it) |
| JP (1) | JP5718897B2 (it) |
| AU (1) | AU2010238289B2 (it) |
| CA (1) | CA2757592C (it) |
| CY (1) | CY1118061T1 (it) |
| DK (1) | DK2419427T3 (it) |
| ES (1) | ES2580781T3 (it) |
| GB (1) | GB0906472D0 (it) |
| HR (1) | HRP20160725T1 (it) |
| HU (1) | HUE028138T2 (it) |
| ME (1) | ME02463B (it) |
| PL (1) | PL2419427T3 (it) |
| PT (1) | PT2419427T (it) |
| RS (1) | RS55038B1 (it) |
| SI (1) | SI2419427T1 (it) |
| SM (1) | SMT201600220B (it) |
| WO (1) | WO2010119284A1 (it) |
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| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
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| UA111382C2 (uk) | 2011-10-10 | 2016-04-25 | Оріон Корпорейшн | Інгібітори протеїнкінази |
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| WO2014142255A1 (ja) | 2013-03-14 | 2014-09-18 | 武田薬品工業株式会社 | 複素環化合物 |
| TWI628176B (zh) * | 2013-04-04 | 2018-07-01 | 奧利安公司 | 蛋白質激酶抑制劑 |
| SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
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| ES2756748T3 (es) | 2014-10-03 | 2020-04-27 | Novartis Ag | Uso de derivados de piridilo bicíclicos de anillo fusionado como inhibidores de fgfr4 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
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| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
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| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| TWI800489B (zh) * | 2016-08-12 | 2023-05-01 | 大陸商江蘇豪森藥業集團有限公司 | Ｆｇｆｒ４抑制劑及其製備方法和應用 |
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| JPWO2019189241A1 (ja) | 2018-03-28 | 2021-03-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 肝細胞癌治療剤 |
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| US11466004B2 (en) | 2018-05-04 | 2022-10-11 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
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| CN101679409B (zh) * | 2006-12-22 | 2014-11-26 | Astex治疗学有限公司 | 双环杂环衍生化合物、其医药组合物和其用途 |
| CA2672172C (en) * | 2006-12-22 | 2016-05-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
| WO2008124323A1 (en) | 2007-04-03 | 2008-10-16 | Array Biopharma Inc. | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors |
| ES2602615T3 (es) | 2007-06-12 | 2017-02-21 | Achaogen, Inc. | Agentes antibacterianos |
| WO2009002534A1 (en) | 2007-06-26 | 2008-12-31 | Gilead Colorado, Inc. | Imidazopyridinyl thiazolyl histone deacetylase inhibitors |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
-
2009
- 2009-04-15 GB GBGB0906472.6A patent/GB0906472D0/en not_active Ceased
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2010
- 2010-04-15 WO PCT/GB2010/050617 patent/WO2010119284A1/en active Application Filing
- 2010-04-15 DK DK10718659.5T patent/DK2419427T3/en active
- 2010-04-15 ME MEP-2016-133A patent/ME02463B/me unknown
- 2010-04-15 SI SI201031219A patent/SI2419427T1/sl unknown
- 2010-04-15 EP EP10718659.5A patent/EP2419427B1/en active Active
- 2010-04-15 CA CA2757592A patent/CA2757592C/en active Active
- 2010-04-15 AU AU2010238289A patent/AU2010238289B2/en active Active
- 2010-04-15 PT PT107186595T patent/PT2419427T/pt unknown
- 2010-04-15 US US13/264,593 patent/US8481531B2/en active Active
- 2010-04-15 PL PL10718659.5T patent/PL2419427T3/pl unknown
- 2010-04-15 ES ES10718659.5T patent/ES2580781T3/es active Active
- 2010-04-15 JP JP2012505238A patent/JP5718897B2/ja active Active
- 2010-04-15 HU HUE10718659A patent/HUE028138T2/en unknown
- 2010-04-15 RS RS20160503A patent/RS55038B1/sr unknown
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2016
- 2016-06-24 HR HRP20160725TT patent/HRP20160725T1/hr unknown
- 2016-07-05 CY CY20161100619T patent/CY1118061T1/el unknown
- 2016-07-05 SM SM201600220T patent/SMT201600220B/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0906472D0 (en) | 2009-05-20 |
| PT2419427T (pt) | 2016-07-13 |
| CY1118061T1 (el) | 2017-06-28 |
| RS55038B1 (sr) | 2016-12-30 |
| CA2757592A1 (en) | 2010-10-21 |
| AU2010238289B2 (en) | 2015-12-03 |
| CA2757592C (en) | 2018-08-21 |
| EP2419427A1 (en) | 2012-02-22 |
| SI2419427T1 (sl) | 2016-08-31 |
| WO2010119284A1 (en) | 2010-10-21 |
| ES2580781T3 (es) | 2016-08-26 |
| HRP20160725T1 (hr) | 2016-09-23 |
| US8481531B2 (en) | 2013-07-09 |
| PL2419427T3 (pl) | 2016-12-30 |
| JP5718897B2 (ja) | 2015-05-13 |
| JP2012524055A (ja) | 2012-10-11 |
| ME02463B (me) | 2017-02-20 |
| AU2010238289A1 (en) | 2011-12-08 |
| US20120035171A1 (en) | 2012-02-09 |
| DK2419427T3 (en) | 2016-07-18 |
| EP2419427B1 (en) | 2016-04-06 |
| HUE028138T2 (en) | 2016-12-28 |
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