SMT201300093B - Formulazioni di vwf ricombinante liofilizzate - Google Patents
Formulazioni di vwf ricombinante liofilizzateInfo
- Publication number
- SMT201300093B SMT201300093B SM201300093T SM201300093T SMT201300093B SM T201300093 B SMT201300093 B SM T201300093B SM 201300093 T SM201300093 T SM 201300093T SM 201300093 T SM201300093 T SM 201300093T SM T201300093 B SMT201300093 B SM T201300093B
- Authority
- SM
- San Marino
- Prior art keywords
- lyophilized recombinant
- formulations
- recombinant vwf
- rvwf
- vwf formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10727308P | 2008-10-21 | 2008-10-21 | |
PCT/US2009/061470 WO2010048275A2 (en) | 2008-10-21 | 2009-10-21 | Lyophilized recombinant vwf formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT201300093B true SMT201300093B (it) | 2013-11-08 |
Family
ID=42109151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201300093T SMT201300093B (it) | 2008-10-21 | 2013-08-16 | Formulazioni di vwf ricombinante liofilizzate |
Country Status (21)
Country | Link |
---|---|
US (4) | US20100099603A1 (it) |
EP (2) | EP2601932A1 (it) |
JP (6) | JP5781931B2 (it) |
KR (2) | KR101953494B1 (it) |
CN (2) | CN102387784B (it) |
AR (2) | AR074054A1 (it) |
AU (1) | AU2009307648C1 (it) |
BR (1) | BRPI0919693A2 (it) |
CA (1) | CA2740919A1 (it) |
CY (1) | CY1113869T1 (it) |
DK (1) | DK2349314T3 (it) |
ES (1) | ES2409032T3 (it) |
HR (1) | HRP20130414T1 (it) |
MX (1) | MX2011004247A (it) |
NZ (1) | NZ592704A (it) |
PL (1) | PL2349314T3 (it) |
PT (1) | PT2349314E (it) |
SI (1) | SI2349314T1 (it) |
SM (1) | SMT201300093B (it) |
TW (3) | TWI593421B (it) |
WO (1) | WO2010048275A2 (it) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2740919A1 (en) * | 2008-10-21 | 2010-04-29 | Baxter International Inc. | Lyophilized recombinant vwf formulations |
AU2010202125B1 (en) | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
WO2011150284A2 (en) | 2010-05-26 | 2011-12-01 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
AU2011316111B2 (en) | 2010-10-12 | 2015-05-28 | Merz Pharma Gmbh & Co. Kgaa | Formulation suitable for stabilizing proteins, which is free of mammalian excipients |
EP2717905B1 (en) * | 2011-06-10 | 2018-05-23 | Baxalta GmbH | Treatment of coagulation disease by administration of recombinant vwf |
EP2698162A1 (en) * | 2012-08-15 | 2014-02-19 | Credentis AG | Method for producing a composition for treating a tooth lesion |
WO2014141149A1 (en) * | 2013-03-15 | 2014-09-18 | Glaxosmithkline Intellectual Property (No.2) Limited | Formulations with reduced viscosity |
NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
CN106414719B (zh) | 2014-06-13 | 2020-02-14 | 杰特有限公司 | 生物反应器中重组von Willebrand因子的改进生产 |
AU2016225111B2 (en) * | 2015-02-27 | 2021-12-09 | Board Of Regents, The University Of Texas System | Polypeptide therapeutics and uses thereof |
BE1023343B1 (nl) * | 2015-05-20 | 2017-02-09 | Mycartis Nv | Opslagbuffer |
JP7307047B2 (ja) | 2017-07-07 | 2023-07-11 | 武田薬品工業株式会社 | 組換えvwfの投与による重度のフォンヴィレブランド病を患う患者における消化管出血の治療 |
AU2018298232A1 (en) | 2017-07-07 | 2020-01-30 | Takeda Pharmaceutical Company Limited | Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant VWF |
EP3672644A1 (en) | 2017-08-23 | 2020-07-01 | CSL Behring GmbH | Method for virus filtration of von willebrand factor |
WO2019183290A1 (en) | 2018-03-21 | 2019-09-26 | Baxalta Incorporated | Separation of vwf and vwf propeptide by chromatographic methods |
WO2020055812A1 (en) | 2018-09-10 | 2020-03-19 | Lung Therapeutics, Inc. | Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis |
BR112021015068A2 (pt) | 2019-02-01 | 2021-10-05 | Takeda Pharmaceutical Company Limited | Métodos de tratamento profilático usando vwf recombinante (rvwf) |
EP4028046B1 (en) | 2019-09-11 | 2024-02-14 | Takeda Pharmaceutical Company Limited | Methods of treatment related to complexes of von willebrand factor and complement c1q |
AU2021216945A1 (en) | 2020-02-04 | 2022-09-01 | Takeda Pharmaceutical Company Limited | Treatment of menorrhagia in patients with severe von Willebrand Disease by administration of recombinant VWF |
CN111789867B (zh) * | 2020-08-27 | 2022-01-11 | 中国人民解放军军事科学院军事医学研究院 | 一种适用于提高血浆干粉功能的适配液 |
JP7371208B2 (ja) * | 2022-01-19 | 2023-10-30 | Kmバイオロジクス株式会社 | von Willebrand因子含有製剤 |
WO2023170680A1 (en) | 2022-03-08 | 2023-09-14 | Equashield Medical Ltd | Fluid transfer station in a robotic pharmaceutical preparation system |
Family Cites Families (63)
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US3941763A (en) * | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
US8597910B1 (en) | 1985-04-11 | 2013-12-03 | Children's Medical Center Corporation | DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells |
WO1986006096A1 (en) | 1985-04-11 | 1986-10-23 | The Children's Medical Center Corporation | Von willebrand factor |
US5900476A (en) | 1986-05-30 | 1999-05-04 | The Scripps Research Institute | Therapeutic domains of van Willebrand factor |
US5201033A (en) | 1990-01-17 | 1993-04-06 | International Business Machines Corporation | Method for controlling cursor movements on certain computer workstations |
AU2253392A (en) * | 1991-06-20 | 1993-01-25 | Rhone-Poulenc Rorer International (Holdings) Inc. | Therapeutic fragments of von willebrand factor |
US5847086A (en) | 1991-06-20 | 1998-12-08 | Centeon L.L.C. | Therapeutic fragments of von Willebrand factor |
US5670132A (en) * | 1994-09-20 | 1997-09-23 | Immunomedics, Inc. | Modified radioantibody fragments for reduced renal uptake |
DE4435392B4 (de) * | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
DE4435485C1 (de) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
US20010046487A1 (en) | 1994-12-30 | 2001-11-29 | Roser Bruce J. | Methods for loading platelets, stabilizing platelets for dry storage and compositions obtained thereby |
US7244824B2 (en) * | 1995-01-19 | 2007-07-17 | Quadrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
GB9501040D0 (en) | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
US7253262B2 (en) * | 1995-01-19 | 2007-08-07 | Quandrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
IL122910A (en) | 1995-07-27 | 2002-05-23 | Genentech Inc | Stable isotonic protein formulation that has undergone lyophilization |
US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6005077A (en) * | 1995-11-10 | 1999-12-21 | Immuno Aktiengesellschaft | Use of von willebrand factor and pharmaceutical formulation |
US5925738A (en) * | 1995-12-01 | 1999-07-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
AT403764B (de) * | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
DE69734247T2 (de) * | 1996-07-19 | 2006-06-22 | The Regents Of The University Of Michigan, Ann Arbor | Für den von willebrand faktor der hunde kodierende dna und verfahren zu ihrer verwendung |
SE9604296D0 (sv) | 1996-11-22 | 1996-11-22 | Astra Ab | New pharmaceutical formulation of polypeptides |
US20020019036A1 (en) | 1996-12-13 | 2002-02-14 | Hans-Peter Schwarz | Von willebrand factor derivatives and methods of isolating proteins that bind to von willebrand factor |
AT405740B (de) * | 1996-12-13 | 1999-11-25 | Immuno Ag | Von willebrand-faktor-derivat sowie ein verfahren zur isolierung von proteinen |
AT405403B (de) * | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
AT406373B (de) | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
AT405485B (de) * | 1997-05-28 | 1999-08-25 | Immuno Ag | Eine das vwf-propeptid enthaltende pharmazeutische präparation |
US6005007A (en) * | 1997-07-18 | 1999-12-21 | Farmer; Luc J. | Retinoids, methods for their production and use |
US6310183B1 (en) * | 1997-09-10 | 2001-10-30 | Novo Nordisk A/S | Coagulation factor VIIa composition |
US6531577B1 (en) | 1997-12-15 | 2003-03-11 | Hemasure Denmark A/S | von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations |
EP1148063A1 (de) | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
US20040038878A1 (en) * | 2000-08-04 | 2004-02-26 | Masahiko Tanikawa | Injectable protein formulations |
ES2644275T3 (es) | 2000-08-11 | 2017-11-28 | Chugai Seiyaku Kabushiki Kaisha | Preparaciones estabilizadas que contienen anticuerpos |
DE10043124A1 (de) * | 2000-08-31 | 2002-03-14 | Max Delbrueck Centrum | Verfahren zur Diagnostik von neuronalen Erkrankungen sowie zur Behandlung der defizienten primären Hämostase |
JP4477299B2 (ja) | 2000-10-02 | 2010-06-09 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 因子viiグリコ型 |
PT1324776E (pt) * | 2000-10-12 | 2009-12-23 | Genentech Inc | Formulações de proteína concentradas de viscosidade reduzida |
UA86744C2 (en) | 2002-06-21 | 2009-05-25 | Ново Нордиск Хэлс Кеа Аг | Pegylated factor vii glycoforms |
WO2004039337A2 (en) | 2002-10-31 | 2004-05-13 | Protein Design Labs, Inc. | Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization |
ES2229931B1 (es) | 2003-10-03 | 2006-01-16 | Grifols, S.A. | Composicion liquida bilogicamente estable de fviii, de fvw o del complejo fviii/fvw humanos. |
FR2861395B1 (fr) | 2003-10-23 | 2006-02-17 | Lab Francais Du Fractionnement | Facteur viii viralement securise a faible teneur en multimeres superieurs |
DK2298287T3 (en) * | 2003-12-19 | 2018-07-23 | Novo Nordisk Healthcare Ag | Stabilized compositions of factor VII polypeptides |
US20060008415A1 (en) * | 2004-06-25 | 2006-01-12 | Protein Design Labs, Inc. | Stable liquid and lyophilized formulation of proteins |
FR2874216B1 (fr) * | 2004-08-16 | 2006-11-03 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu |
DE102004044421B4 (de) * | 2004-09-14 | 2010-06-24 | Biotest Ag | Verfahren zur Trennung eines von Willebrand Faktors mit einer spezifischen VWF-Aktivität von wenigstens 50 E/mg VWF-Antigen von einem von Willebrand Faktor mit niedriger Aktivität und Verwendung von Hydroxylapatit dafür |
DK1835938T3 (da) * | 2004-12-27 | 2013-11-04 | Baxter Int | Polymer-von Willebrand-faktor-konjugater |
EP1707634A1 (en) * | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
GB0509443D0 (en) * | 2005-05-09 | 2005-06-15 | Prometic Biosciences Ltd | Affinity adsorbents for factor VIII and von willebrand's factor |
EP1899462B1 (en) * | 2005-07-02 | 2011-03-09 | Arecor Limited | Stable aqueous systems comprising proteins |
US7956160B2 (en) * | 2005-07-22 | 2011-06-07 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
PT1986612E (pt) * | 2006-02-07 | 2012-11-06 | Shire Human Genetic Therapies | Composição estável de glucocerebrosidase |
GB0700523D0 (en) * | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
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WO2008127654A2 (en) * | 2007-04-11 | 2008-10-23 | The University Of North Carolina At Chapel Hill | Methods and compositions for intra-articular coagulation proteins |
JP5401446B2 (ja) * | 2007-04-26 | 2014-01-29 | バイエル ヘルスケア エルエルシー | 凍結貯蔵を目的とした、組み換えタンパク質溶液の安定化 |
PL2167117T3 (pl) * | 2007-06-13 | 2013-01-31 | Csl Behring Gmbh | Zastosowanie stabilizowanego VWP preparatu FVIII do podawania pozanaczyniowego w terapii i profilaktyce zaburzeń krzepliwości krwi |
FR2920429B1 (fr) * | 2007-08-30 | 2012-10-05 | Lfb Biotechnologies | Procede de purification du facteur viii et du facteur von willebrand |
TW201731488A (zh) * | 2007-12-28 | 2017-09-16 | 巴克斯歐塔公司 | 重組vwf調配物 |
ES2298096B1 (es) | 2008-01-08 | 2009-01-01 | Grifols, S.A. | Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos. |
DE102008032361A1 (de) * | 2008-07-10 | 2010-01-21 | Csl Behring Gmbh | Der Einsatz von Faktor VIII und vWF bzw. vWF-enthaltenden Konzentraten zur Therapie der durch Thrombocyten-Inhibitoren induzierte Koagulopathie |
CN104013569A (zh) * | 2008-10-15 | 2014-09-03 | 精达制药公司 | 高浓缩药物颗粒、制剂、混悬剂及其应用 |
CA2740919A1 (en) * | 2008-10-21 | 2010-04-29 | Baxter International Inc. | Lyophilized recombinant vwf formulations |
KR20110093775A (ko) * | 2008-11-03 | 2011-08-18 | 바이엘 헬스케어 엘엘씨 | 혈우병 치료 방법 |
EP2393501A1 (en) * | 2009-02-05 | 2011-12-14 | Pierre Philippart | Method and means for producing tissues and tissues obtained |
SG178478A1 (en) * | 2009-08-20 | 2012-04-27 | Baxter Int | Purification of vwf for increased removal of non-lipid enveloped viruses |
-
2009
- 2009-10-21 CA CA2740919A patent/CA2740919A1/en not_active Abandoned
- 2009-10-21 JP JP2011532347A patent/JP5781931B2/ja active Active
- 2009-10-21 CN CN200980142453.5A patent/CN102387784B/zh active Active
- 2009-10-21 EP EP13150822.8A patent/EP2601932A1/en active Pending
- 2009-10-21 PT PT97408223T patent/PT2349314E/pt unknown
- 2009-10-21 US US12/603,064 patent/US20100099603A1/en not_active Abandoned
- 2009-10-21 TW TW103141771A patent/TWI593421B/zh active
- 2009-10-21 MX MX2011004247A patent/MX2011004247A/es active IP Right Grant
- 2009-10-21 TW TW098135542A patent/TWI508735B/zh active
- 2009-10-21 AU AU2009307648A patent/AU2009307648C1/en active Active
- 2009-10-21 CN CN201410067147.2A patent/CN103919736A/zh active Pending
- 2009-10-21 KR KR1020177011494A patent/KR101953494B1/ko active IP Right Grant
- 2009-10-21 EP EP09740822A patent/EP2349314B1/en not_active Revoked
- 2009-10-21 PL PL09740822T patent/PL2349314T3/pl unknown
- 2009-10-21 WO PCT/US2009/061470 patent/WO2010048275A2/en active Application Filing
- 2009-10-21 NZ NZ592704A patent/NZ592704A/xx unknown
- 2009-10-21 ES ES09740822T patent/ES2409032T3/es active Active
- 2009-10-21 DK DK09740822.3T patent/DK2349314T3/da active
- 2009-10-21 TW TW106107483A patent/TWI670072B/zh active
- 2009-10-21 KR KR1020117011539A patent/KR101772674B1/ko active IP Right Grant
- 2009-10-21 AR ARP090104052A patent/AR074054A1/es not_active Application Discontinuation
- 2009-10-21 BR BRPI0919693-5A patent/BRPI0919693A2/pt not_active Application Discontinuation
- 2009-10-21 SI SI200930558T patent/SI2349314T1/sl unknown
-
2013
- 2013-02-12 US US13/765,526 patent/US20130172269A1/en not_active Abandoned
- 2013-04-02 CY CY20131100272T patent/CY1113869T1/el unknown
- 2013-05-10 HR HRP20130414AT patent/HRP20130414T1/hr unknown
- 2013-08-16 SM SM201300093T patent/SMT201300093B/it unknown
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2014
- 2014-04-18 JP JP2014086239A patent/JP2014133758A/ja not_active Withdrawn
-
2015
- 2015-11-12 US US14/939,364 patent/US10232022B2/en active Active
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2016
- 2016-02-26 JP JP2016035672A patent/JP6425674B2/ja active Active
-
2018
- 2018-09-03 JP JP2018164880A patent/JP2018199715A/ja not_active Withdrawn
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2019
- 2019-01-25 US US16/258,490 patent/US11191813B2/en active Active
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2020
- 2020-02-05 AR ARP200100313A patent/AR118012A2/es not_active Application Discontinuation
- 2020-06-08 JP JP2020099260A patent/JP7003183B2/ja active Active
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2021
- 2021-12-28 JP JP2021214216A patent/JP2022037215A/ja not_active Withdrawn
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