SK423090A3 - Recombinant molecule dna coding protein neurotrophin-3, pharmaceutical compositions containing its and their use - Google Patents

Recombinant molecule dna coding protein neurotrophin-3, pharmaceutical compositions containing its and their use Download PDF

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Publication number
SK423090A3
SK423090A3 SK4230-90A SK423090A SK423090A3 SK 423090 A3 SK423090 A3 SK 423090A3 SK 423090 A SK423090 A SK 423090A SK 423090 A3 SK423090 A3 SK 423090A3
Authority
SK
Slovakia
Prior art keywords
bdnf
ngf
neurotrophin
amino acid
protein
Prior art date
Application number
SK4230-90A
Other languages
English (en)
Slovak (sk)
Other versions
SK279660B6 (sk
Inventor
Andreas Hohn
Joachim Leibrock
Karen Bailey
Yves-Alain Barde
Hans F E Thoenen
Peter C Maisonpierre
Mark E Furth
Ronald M Lindsay
George Yancopoulos
Original Assignee
Max Planck Gesellschaft
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/400,591 external-priority patent/US5180820A/en
Application filed by Max Planck Gesellschaft, Regeneron Pharma filed Critical Max Planck Gesellschaft
Publication of SK423090A3 publication Critical patent/SK423090A3/sk
Publication of SK279660B6 publication Critical patent/SK279660B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B75/00—Other engines
    • F02B75/02—Engines characterised by their cycles, e.g. six-stroke
    • F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
    • F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK4230-90A 1989-08-30 1990-08-30 Rekombinantná molekula dna, ktorá kóduje proteín n SK279660B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/400,591 US5180820A (en) 1989-08-30 1989-08-30 Brain-derived neurotrophic factor
US49000490A 1990-03-07 1990-03-07
US57018990A 1990-08-20 1990-08-20

Publications (2)

Publication Number Publication Date
SK423090A3 true SK423090A3 (en) 1999-02-11
SK279660B6 SK279660B6 (sk) 1999-02-11

Family

ID=27410411

Family Applications (1)

Application Number Title Priority Date Filing Date
SK4230-90A SK279660B6 (sk) 1989-08-30 1990-08-30 Rekombinantná molekula dna, ktorá kóduje proteín n

Country Status (21)

Country Link
EP (1) EP0441947B1 (pt)
KR (1) KR100196203B1 (pt)
CN (1) CN1124342C (pt)
AT (1) ATE153074T1 (pt)
AU (1) AU643705B2 (pt)
CA (1) CA2040437C (pt)
CZ (1) CZ286015B6 (pt)
DE (1) DE69030719T2 (pt)
ES (1) ES2100891T3 (pt)
FI (1) FI105343B (pt)
GR (1) GR1000980B (pt)
HK (1) HK1006579A1 (pt)
IE (1) IE903129A1 (pt)
IL (1) IL95511A (pt)
LV (1) LV10792B (pt)
NO (1) NO303694B1 (pt)
NZ (1) NZ235086A (pt)
PT (1) PT95153B (pt)
SG (1) SG70560A1 (pt)
SK (1) SK279660B6 (pt)
WO (1) WO1991003569A1 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
ES2104743T3 (es) * 1991-02-18 1997-10-16 Takeda Chemical Industries Ltd Metodo para producir factor 2 de crecimiento nervioso humano.
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
EP0755682A1 (en) * 1991-07-10 1997-01-29 Regeneron Pharmaceuticals, Inc. Methods of treatment of motor neuron diseases using members of the BDNF/NT-3/NGF family of molecules
DE4237047A1 (en) * 1991-11-04 1993-05-06 I N R O Handels-Gmbh, 8750 Aschaffenburg, De Drug contg. polypeptide homologous to nerve growth factor and slow virus sequence - for treating amyotrophic lateral sclerosis, spinal muscle atrophy or Parkinson's disease
EP0573904B1 (en) * 1992-06-08 2001-09-26 Takeda Chemical Industries, Ltd. Therapeutic agent for neutropenia
AU4535993A (en) * 1992-06-12 1994-01-04 Regeneron Pharmaceuticals, Inc. Therapeutic and diagnostic methods based on neurotrophin-4 expression
EP0662146B1 (en) * 1992-09-03 2000-07-12 The Regents Of The University Of California Dorsal tissue affecting factor and compositions
ATE350386T1 (de) * 1992-11-13 2007-01-15 Immunex Corp Elk ligand, ein cytokin
AU5891394A (en) * 1993-02-11 1994-08-29 Erziehungsdirektion Of The Canton Zurich A combination of neurotrophin and antibody directed toward myelin-associated neurite growth inhibitory protein promotes central nervous system regeneration
JPH07246040A (ja) * 1993-07-06 1995-09-26 Takeda Chem Ind Ltd ニューロトロフィン−３遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物
WO1995026363A1 (en) * 1994-03-29 1995-10-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Neurotrophin-6: a new member of the neurotrophin family
AU2460595A (en) * 1994-05-06 1995-11-29 Regeneron Pharmaceuticals, Inc. Methods based on the role of neurotrophin 3 in female reproduction
US6303769B1 (en) 1994-07-08 2001-10-16 Immunex Corporation Lerk-5 dna
JP3738281B2 (ja) * 1994-07-22 2006-01-25 アベンティス ファーマ株式会社 新規な骨芽細胞増殖因子
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
JPH10511544A (ja) * 1994-12-05 1998-11-10 ベーリンガー マントハイム ゲゼルシャフト ミット ベシュレンクテル ハフツング 変性神経損傷の診断及び再生のための新規遺伝子及び遺伝子産物
US5859311A (en) * 1995-11-27 1999-01-12 University Of Kentucky Research Foundation Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use
EP1997900A3 (en) 1996-04-05 2010-10-06 Novartis Vaccines and Diagnostics, Inc. Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
CZ250499A3 (cs) * 1997-01-17 1999-11-17 Rhone-Poulenc Rorer S. A. Použití nukleové kyseliny k indukci inervace svalů a růstu axonů motorických neuronů
CA2277955A1 (en) 1997-01-23 1998-07-30 Michiko Kishino Remedies for diabetes
EP1050758A1 (en) * 1999-05-03 2000-11-08 Evotec BioSystems AG Methods of diagnosing or treating neuropsychiatric diseases on basis of increased cerebrospinal fluid levels of neurotrophin 3
ATE343793T1 (de) * 1999-05-03 2006-11-15 Evotec Ag Methode zur diagnostizierung, prognose oder evaluation von behandlung der depressionen, basiert auf erhöhte neurotrophin concentrationen in zerebrospinale flüssigkeit.
CN1112215C (zh) * 1999-12-28 2003-06-25 潘晓东 神经生长因子在治疗有机溶剂中毒性周围神经病中的用途
WO2006108651A2 (en) * 2005-04-12 2006-10-19 Develogen Aktiengesellschaft Use of activin products for preventing and treating diabetes and/or metabolic syndrome
US20140314787A1 (en) 2011-11-08 2014-10-23 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute Treatment for neurodegenerative diseases
US20140294732A1 (en) 2011-11-08 2014-10-02 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute Early diagnostic of neurodegenerative diseases
EP2870242A1 (en) 2012-07-05 2015-05-13 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research New treatment for neurodegenerative diseases
CN110862447A (zh) * 2019-11-29 2020-03-06 武汉赛维尔生物科技有限公司 一种提高神经营养因子nt-3碱性蛋白产量的蛋白改造方法
CN113940308A (zh) * 2021-04-28 2022-01-18 重庆腾达牧业有限公司 大足黑山羊哺乳舍饲养管理方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699875A (en) * 1982-11-24 1987-10-13 Baylor College Of Medicine Diagnosis of amyotrophic lateral sclerosis by neurotrophic factors
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US6709837B1 (en) * 1989-03-10 2004-03-23 Takeda Chemical Industries, Inc. Polypeptide and production thereof
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US7020718B2 (en) 2000-05-15 2006-03-28 Hewlett-Packard Development Company, L.P. System and method of aggregating discontiguous address ranges into addresses and masks using a plurality of repeating address blocks

Also Published As

Publication number Publication date
CN1124342C (zh) 2003-10-15
LV10792B (en) 1995-12-20
HK1006579A1 (en) 1999-03-05
LV10792A (lv) 1995-08-20
WO1991003569A1 (en) 1991-03-21
NO911688D0 (no) 1991-04-29
IL95511A0 (en) 1991-06-30
ATE153074T1 (de) 1997-05-15
AU6404990A (en) 1991-04-08
KR100196203B1 (ko) 1999-06-15
IE903129A1 (en) 1991-03-13
CA2040437A1 (en) 1991-03-01
CZ286015B6 (cs) 1999-12-15
EP0441947B1 (en) 1997-05-14
IL95511A (en) 2000-10-31
PT95153A (pt) 1991-05-22
KR920702865A (ko) 1992-10-28
NO911688L (no) 1991-05-31
CZ423090A3 (cs) 1999-09-15
EP0441947A4 (en) 1992-05-13
DE69030719T2 (de) 1997-09-25
AU643705B2 (en) 1993-11-25
SG70560A1 (en) 2000-02-22
SK279660B6 (sk) 1999-02-11
FI105343B (fi) 2000-07-31
EP0441947A1 (en) 1991-08-21
CN1052141A (zh) 1991-06-12
NZ235086A (en) 1993-10-26
CA2040437C (en) 2002-10-22
DE69030719D1 (de) 1997-06-19
ES2100891T3 (es) 1997-07-01
GR1000980B (el) 1993-03-31
FI912105A0 (fi) 1991-04-30
PT95153B (pt) 1993-12-31
GR900100647A (en) 1991-12-30
NO303694B1 (no) 1998-08-17

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Legal Events

Date Code Title Description
MK4A Patent expired

Expiry date: 20100830