SK286701B6 - Indolové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Indolové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

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Publication number
SK286701B6
SK286701B6 SK203-2003A SK2032003A SK286701B6 SK 286701 B6 SK286701 B6 SK 286701B6 SK 2032003 A SK2032003 A SK 2032003A SK 286701 B6 SK286701 B6 SK 286701B6
Authority
SK
Slovakia
Prior art keywords
indole
ethyl
piperidin
chloro
methylphenyl
Prior art date
Application number
SK203-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK2032003A3 (en
Inventor
Jakob Felding
Benny Bang-Andersen
Garrick Paul Smith
Kim Andersen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of SK2032003A3 publication Critical patent/SK2032003A3/sk
Publication of SK286701B6 publication Critical patent/SK286701B6/sk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
SK203-2003A 2000-07-21 2001-07-17 Indolové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie SK286701B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001123 2000-07-21
PCT/DK2001/000507 WO2002008223A1 (en) 2000-07-21 2001-07-17 Indole derivatives useful for the treatment of cns disorders

Publications (2)

Publication Number Publication Date
SK2032003A3 SK2032003A3 (en) 2003-06-03
SK286701B6 true SK286701B6 (sk) 2009-03-05

Family

ID=8159625

Family Applications (1)

Application Number Title Priority Date Filing Date
SK203-2003A SK286701B6 (sk) 2000-07-21 2001-07-17 Indolové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (29)

Country Link
US (1) US6743809B2 (no)
EP (1) EP1305307B1 (no)
JP (1) JP2004504396A (no)
KR (1) KR100851793B1 (no)
CN (1) CN1264838C (no)
AR (1) AR029858A1 (no)
AT (1) ATE266024T1 (no)
AU (2) AU8173801A (no)
BG (1) BG107528A (no)
BR (1) BR0112998A (no)
CA (1) CA2416212C (no)
CZ (1) CZ301114B6 (no)
DE (1) DE60103162T2 (no)
EA (1) EA004749B1 (no)
ES (1) ES2219554T3 (no)
HK (1) HK1059782A1 (no)
HR (1) HRP20030015A2 (no)
HU (1) HUP0302820A3 (no)
IL (2) IL153605A0 (no)
IS (1) IS2172B (no)
MX (1) MXPA02012927A (no)
NO (1) NO323799B1 (no)
NZ (1) NZ523436A (no)
PT (1) PT1305307E (no)
SK (1) SK286701B6 (no)
TR (1) TR200401488T4 (no)
UA (1) UA73995C2 (no)
WO (1) WO2002008223A1 (no)
ZA (1) ZA200300287B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1882565A (zh) 2003-11-17 2006-12-20 贝林格尔.英格海姆国际有限公司 哌啶取代的吲哚或其杂环衍生物以及它们作为趋化因子-受体(ccr-3)调节剂的用途
TWI391387B (zh) * 2004-05-12 2013-04-01 Eisai R&D Man Co Ltd 具有哌啶環之吲哚衍生物
CA2606550C (en) 2005-04-30 2014-05-27 Boehringer Ingelheim International Gmbh Piperidine-substituted indoles
ATE537166T1 (de) 2006-10-27 2011-12-15 Boehringer Ingelheim Int Piperidylpropanthiole als ccr3-modulatoren
CN101486654B (zh) * 2009-03-04 2012-10-10 西安近代化学研究所 2-甲基-3-硝基苯乙酸合成方法
CN110041318B (zh) * 2018-01-17 2022-07-29 中国科学院上海药物研究所 一类多巴胺d5受体激动剂及其制备和应用
CN110498789B (zh) * 2018-05-17 2022-04-05 上海医药工业研究院 芳烷哌啶类衍生物及其在多靶点抗抑郁症中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
AT332401B (de) * 1973-11-26 1976-09-27 Roussel Uclaf Verfahren zur herstellung von neuen (4'-(3''-indolyl)-piperidino)-alkylarylketonderivaten
GB2208646B (en) * 1987-08-13 1991-06-26 Glaxo Group Ltd Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
CA2141810A1 (en) * 1992-08-05 1994-02-17 Ian A. Cliffe Amide derivatives
EP0695301B1 (en) * 1993-04-22 1996-10-30 Pfizer Limited Indole derivatives as 5-ht1-like agonists for use in migraine
ES2063700B1 (es) * 1993-04-28 1995-07-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, proceso para su preparacion y composiciones farmaceuticas que lo contengan.
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
GB9718712D0 (en) * 1997-09-03 1997-11-12 Merck Sharp & Dohme Theraputic Agents

Also Published As

Publication number Publication date
WO2002008223A1 (en) 2002-01-31
KR100851793B1 (ko) 2008-08-13
NZ523436A (en) 2004-07-30
US20030166664A1 (en) 2003-09-04
IS2172B (is) 2006-11-15
KR20030017643A (ko) 2003-03-03
BR0112998A (pt) 2003-06-24
HUP0302820A3 (en) 2006-04-28
NO323799B1 (no) 2007-07-09
DE60103162T2 (de) 2005-05-04
CA2416212A1 (en) 2002-01-31
MXPA02012927A (es) 2003-05-15
BG107528A (bg) 2003-10-31
HRP20030015A2 (en) 2005-02-28
SK2032003A3 (en) 2003-06-03
ES2219554T3 (es) 2004-12-01
HUP0302820A2 (hu) 2003-12-29
CA2416212C (en) 2007-10-30
ZA200300287B (en) 2004-03-02
JP2004504396A (ja) 2004-02-12
AU8173801A (en) 2002-02-05
DE60103162D1 (de) 2004-06-09
EA004749B1 (ru) 2004-08-26
PT1305307E (pt) 2004-09-30
CN1451002A (zh) 2003-10-22
IS6663A (is) 2002-12-23
US6743809B2 (en) 2004-06-01
EA200300179A1 (ru) 2003-06-26
AR029858A1 (es) 2003-07-16
NO20030127L (no) 2003-01-10
ATE266024T1 (de) 2004-05-15
IL153605A (en) 2008-07-08
NO20030127D0 (no) 2003-01-10
CN1264838C (zh) 2006-07-19
HK1059782A1 (en) 2004-07-16
IL153605A0 (en) 2003-07-06
PL359157A1 (en) 2004-08-23
CZ301114B6 (cs) 2009-11-11
UA73995C2 (en) 2005-10-17
TR200401488T4 (tr) 2004-08-23
AU2001281738B2 (en) 2006-12-21
EP1305307A1 (en) 2003-05-02
CZ2003196A3 (cs) 2003-05-14
EP1305307B1 (en) 2004-05-06

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Legal Events

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20090717