SK11399A3 - A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction - Google Patents

A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction Download PDF

Info

Publication number: SK11399A3
Authority: SK; Slovakia
Prior art keywords: glycine; nutritional; medicament; cyclosporin; renal dysfunction
Prior art date: 1996-07-30

Application number

SK113-99A

Other languages

English (en)

Slovak (sk)

Inventor

Heinz Schneider

Original Assignee

Novartis Nutrition Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-30

Filing date

1997-07-29

Publication date

1999-09-10

1997-07-29 Application filed by Novartis Nutrition Ag filed Critical Novartis Nutrition Ag

1999-09-10 Publication of SK11399A3 publication Critical patent/SK11399A3/sk

Links

DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title claims abstract description 187
239000004471 Glycine Substances 0.000 title claims abstract description 94
239000000203 mixture Substances 0.000 title claims abstract description 58
235000016709 nutrition Nutrition 0.000 title claims abstract description 48
239000003814 drug Substances 0.000 title claims abstract description 38
230000008085 renal dysfunction Effects 0.000 title claims abstract description 19
238000011321 prophylaxis Methods 0.000 title claims abstract description 14
238000002560 therapeutic procedure Methods 0.000 title claims abstract description 14
238000009472 formulation Methods 0.000 title abstract description 14
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238000002360 preparation method Methods 0.000 claims abstract description 22
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PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 41
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235000013024 sodium fluoride Nutrition 0.000 description 1
PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
235000019710 soybean protein Nutrition 0.000 description 1
235000013599 spices Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
235000019157 thiamine Nutrition 0.000 description 1
229960003495 thiamine Drugs 0.000 description 1
239000011721 thiamine Substances 0.000 description 1
KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
229940113082 thymine Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
229940045145 uridine Drugs 0.000 description 1
108010082372 valspodar Proteins 0.000 description 1
229950010938 valspodar Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019156 vitamin B Nutrition 0.000 description 1
239000011720 vitamin B Substances 0.000 description 1
235000019164 vitamin B2 Nutrition 0.000 description 1
239000011716 vitamin B2 Substances 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
235000005282 vitamin D3 Nutrition 0.000 description 1
239000011647 vitamin D3 Substances 0.000 description 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
150000003721 vitamin K derivatives Chemical class 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
229940021056 vitamin d3 Drugs 0.000 description 1
229940046010 vitamin k Drugs 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
239000011686 zinc sulphate Substances 0.000 description 1
235000009529 zinc sulphate Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Mycology (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK113-99A 1996-07-30 1997-07-29 A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction SK11399A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/690,476 US6096785A (en)	1996-07-30	1996-07-30	Amino acid compositions and use thereof in treating renal dysfunction
PCT/EP1997/004125 WO1998004256A1 (en)	1996-07-30	1997-07-29	Amino acid compositions and use thereof in immunosuppression

Publications (1)

Publication Number	Publication Date
SK11399A3 true SK11399A3 (en)	1999-09-10

Family

ID=24772611

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK113-99A SK11399A3 (en)	1996-07-30	1997-07-29	A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction

Country Status (17)

Country	Link
US (2)	US6096785A (ja)
EP (1)	EP0952827A1 (ja)
JP (1)	JP4199308B2 (ja)
KR (1)	KR20000029698A (ja)
CN (1)	CN1146414C (ja)
AU (1)	AU722442B2 (ja)
CA (1)	CA2260956A1 (ja)
CZ (1)	CZ31299A3 (ja)
ID (1)	ID19428A (ja)
IL (1)	IL127907A0 (ja)
MY (1)	MY124560A (ja)
NO (1)	NO325946B1 (ja)
PL (1)	PL331355A1 (ja)
RU (1)	RU2219925C2 (ja)
SK (1)	SK11399A3 (ja)
WO (1)	WO1998004256A1 (ja)
ZA (1)	ZA976807B (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9701674D0 (en) *	1997-01-28	1997-03-19	Novartis Nutrition Ag	Use of organic compounds
US6281244B1 (en) *	1997-06-05	2001-08-28	Novartis Nutrition Ag	Therapeutic use for glycine
ES2221095T3 (es) *	1997-06-05	2004-12-16	Novartis Nutrition Ag	Glicina para prevencion o tratamiento del rechazo de transplantes.
US6288116B1 (en) *	1998-05-13	2001-09-11	Novartis Nutrition Ag	Method of administration of a nutritional product to a person having renal failure
US20070032853A1 (en)	2002-03-27	2007-02-08	Hossainy Syed F	40-O-(2-hydroxy)ethyl-rapamycin coated stent
EP1174143B1 (en) *	2000-07-14	2004-06-02	HealthEcon AG	Green tea extract and use thereof in treating renal dysfunction induced by cyclosporins or ascomycins
US6864242B2 (en) *	2001-03-05	2005-03-08	Stephen P. Ernest	Enteral formulation
US20050118344A1 (en)	2003-12-01	2005-06-02	Pacetti Stephen D.	Temperature controlled crimping
US20060281642A1 (en) *	2005-05-18	2006-12-14	David Colbourne	Lubricating oil composition and use thereof
SG193246A1 (en) *	2011-03-31	2013-10-30	Nestec Sa	Nutritional compositions for increasing arginine levels and methods of using same
BR112013026032A2 (pt) *	2011-04-12	2016-12-20	Nestec Sa	composições nutricionais incluindo ácidos graxos de cadeia ramificada para cicatrização de ferida
JOP20190146A1 (ar)	2016-12-19	2019-06-18	Axcella Health Inc	تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
EP3668499A1 (en)	2017-08-14	2020-06-24	Axcella Health Inc.	Amino acid compositions for the treatment of liver disease
EP3810123A1 (en)	2018-06-20	2021-04-28	Axcella Health Inc.	Compositions and methods for the treatment of fat infiltration in muscle

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5290538A (en) *	1988-12-22	1994-03-01	Skrezek Christian	Nephro protective infusion solutions
US5576287A (en) *	1994-04-29	1996-11-19	Wake Forest University	Method for treating acute renal disease and failure
JPH11501301A (ja) *	1995-02-23	1999-02-02	ノバルティス・ニュートリション・アクチエンゲゼルシャフト	アミノ酸組成物および臨床的栄養補給におけるその使用
US5656608B1 (en) *	1995-02-23	2000-09-26	Novartis Nutrition Ltd	Amino acid compositions and methods of treatment using same

1996
- 1996-07-30 US US08/690,476 patent/US6096785A/en not_active Expired - Fee Related
1997
- 1997-07-25 ID IDP972588A patent/ID19428A/id unknown
- 1997-07-29 CA CA002260956A patent/CA2260956A1/en not_active Abandoned
- 1997-07-29 KR KR1019997000797A patent/KR20000029698A/ko not_active Application Discontinuation
- 1997-07-29 CZ CZ99312A patent/CZ31299A3/cs unknown
- 1997-07-29 EP EP97934554A patent/EP0952827A1/en not_active Withdrawn
- 1997-07-29 IL IL12790797A patent/IL127907A0/xx not_active IP Right Cessation
- 1997-07-29 US US09/230,873 patent/US6204244B1/en not_active Expired - Fee Related
- 1997-07-29 WO PCT/EP1997/004125 patent/WO1998004256A1/en not_active Application Discontinuation
- 1997-07-29 AU AU37716/97A patent/AU722442B2/en not_active Ceased
- 1997-07-29 JP JP50851598A patent/JP4199308B2/ja not_active Expired - Fee Related
- 1997-07-29 PL PL97331355A patent/PL331355A1/xx unknown
- 1997-07-29 CN CNB971969019A patent/CN1146414C/zh not_active Expired - Fee Related
- 1997-07-29 RU RU99103692/15A patent/RU2219925C2/ru not_active IP Right Cessation
- 1997-07-29 MY MYPI97003455A patent/MY124560A/en unknown
- 1997-07-29 SK SK113-99A patent/SK11399A3/sk unknown
- 1997-07-30 ZA ZA976807A patent/ZA976807B/xx unknown
1999
- 1999-01-27 NO NO19990373A patent/NO325946B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1226827A (zh)	1999-08-25
JP4199308B2 (ja)	2008-12-17
KR20000029698A (ko)	2000-05-25
NO325946B1 (no)	2008-08-25
ZA976807B (en)	1999-02-01
CA2260956A1 (en)	1998-02-05
CZ31299A3 (cs)	1999-05-12
NO990373L (no)	1999-01-27
ID19428A (id)	1998-07-09
NO990373D0 (no)	1999-01-27
IL127907A0 (en)	1999-11-30
AU3771697A (en)	1998-02-20
US6096785A (en)	2000-08-01
PL331355A1 (en)	1999-07-05
AU722442B2 (en)	2000-08-03
CN1146414C (zh)	2004-04-21
JP2000515875A (ja)	2000-11-28
RU2219925C2 (ru)	2003-12-27
MY124560A (en)	2006-06-30
WO1998004256A1 (en)	1998-02-05
US6204244B1 (en)	2001-03-20
EP0952827A1 (en)	1999-11-03

Publication	Publication Date	Title
US5231085A (en)	1993-07-27	Compositions and methods for the enhancement of host defense mechanisms
EP0810829B1 (en)	2000-04-12	Amino acid compositions and use thereof in clinical nutrition
DK172673B1 (da)	1999-05-10	Immunstimulerende præparat samt anvendelse heraf
US5612060A (en)	1997-03-18	Enhancement of transplant graft survival through nutritional immunomodulation and immunosuppressive therapy
SK106594A3 (en)	1995-09-13	Nutrituve supplement
SK11399A3 (en)	1999-09-10	A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction
WO2004026294A1 (en)	2004-04-01	Leucine-enriched nutritional compositions
WO1998044793A1 (en)	1998-10-15	Non-steroidal anabolic composition
US6048543A (en)	2000-04-11	Amino acid compositions and use thereof in clinical nutrition
US5268365A (en)	1993-12-07	Nucleotides, nucleosides, and nucleobases in immune function restoration enhancement or maintenance
ES2285700T3 (es)	2007-11-16	Composiciones para mejorar la respuesta inmune.
US6013273A (en)	2000-01-11	Treatment of endotoxic shock
US6864230B2 (en)	2005-03-08	Glutamine rich dietary composition
US6281244B1 (en)	2001-08-28	Therapeutic use for glycine
WO1998004255A1 (en)	1998-02-05	Amino acid composition and use thereof in treating tumor growth and metastasis
EP0882451B1 (en)	2004-05-12	Glycine for prevention or treatment of transplant rejection
RU2740905C2 (ru)	2021-01-21	Питательный продукт для снижения уровней фенилаланина у больных фку
MXPA97006140A (en)	1998-07-03	Compositions of amino acids and the use of them in nutrition clin