SI3952995T1 - Biciklični heteroarilni derivati kot zaviralci ektonukleotid pirofosfataze fosfodiesteraze 1 - Google Patents

Biciklični heteroarilni derivati kot zaviralci ektonukleotid pirofosfataze fosfodiesteraze 1

Info

Publication number
SI3952995T1
SI3952995T1 SI202030281T SI202030281T SI3952995T1 SI 3952995 T1 SI3952995 T1 SI 3952995T1 SI 202030281 T SI202030281 T SI 202030281T SI 202030281 T SI202030281 T SI 202030281T SI 3952995 T1 SI3952995 T1 SI 3952995T1
Authority
SI
Slovenia
Prior art keywords
inhibitors
bicyclic heteroaryl
heteroaryl derivatives
ectonucleotide pyrophosphatase
pyrophosphatase phosphodiesterase
Prior art date
Application number
SI202030281T
Other languages
English (en)
Inventor
Ronald Hawley
Klaus Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of SI3952995T1 publication Critical patent/SI3952995T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
SI202030281T 2019-04-12 2020-04-10 Biciklični heteroarilni derivati kot zaviralci ektonukleotid pirofosfataze fosfodiesteraze 1 SI3952995T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962833455P 2019-04-12 2019-04-12
US201962881111P 2019-07-31 2019-07-31
PCT/US2020/027700 WO2020210649A1 (en) 2019-04-12 2020-04-10 Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors
EP20722196.1A EP3952995B1 (en) 2019-04-12 2020-04-10 Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors

Publications (1)

Publication Number Publication Date
SI3952995T1 true SI3952995T1 (sl) 2023-12-29

Family

ID=70465561

Family Applications (1)

Application Number Title Priority Date Filing Date
SI202030281T SI3952995T1 (sl) 2019-04-12 2020-04-10 Biciklični heteroarilni derivati kot zaviralci ektonukleotid pirofosfataze fosfodiesteraze 1

Country Status (23)

Country Link
US (1) US20220362266A1 (sl)
EP (2) EP3952995B1 (sl)
JP (1) JP2022526432A (sl)
KR (1) KR20210151873A (sl)
CN (1) CN114040915A (sl)
AU (1) AU2020272034A1 (sl)
BR (1) BR112021020241A2 (sl)
CA (1) CA3136443A1 (sl)
DK (1) DK3952995T3 (sl)
ES (1) ES2960987T3 (sl)
FI (1) FI3952995T3 (sl)
HR (1) HRP20231413T1 (sl)
HU (1) HUE064377T2 (sl)
IL (1) IL286966A (sl)
LT (1) LT3952995T (sl)
MX (1) MX2021012305A (sl)
PL (1) PL3952995T3 (sl)
PT (1) PT3952995T (sl)
RS (1) RS64792B1 (sl)
SG (1) SG11202110888QA (sl)
SI (1) SI3952995T1 (sl)
TW (1) TW202103708A (sl)
WO (1) WO2020210649A1 (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022211957A1 (en) * 2021-01-29 2023-07-27 Txinno Bioscience Inc. Novel benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof
WO2022197734A1 (en) * 2021-03-16 2022-09-22 Riboscience Llc Bicyclic heteroaryl boronate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors
CN116444544A (zh) * 2022-01-10 2023-07-18 中国科学院上海药物研究所 苯并咪唑类化合物及其医药用途

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US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
US20090176849A1 (en) * 2005-05-24 2009-07-09 Lek Pharmaceuticals, D.D. Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl) Methyl)-imidazole, dihydroimidazole or benzimidazloe derivatives
CN100427488C (zh) * 2005-10-21 2008-10-22 上海东升新材料有限公司 腺嘌呤类衍生物及其合成方法
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
KR101672511B1 (ko) * 2008-03-06 2016-11-03 아나코르 파마슈티칼스 인코포레이티드 소염제로써 붕소가 함유된 소분자
ES2713873T3 (es) * 2010-04-16 2019-05-24 Nuevolution As Complejos bifuncionales y métodos para hacer y utilizar tales complejos
CN103502249A (zh) * 2011-05-17 2014-01-08 普林斯匹亚生物制药公司 作为酪氨酸激酶抑制剂的氮杂吲哚衍生物
AU2015329955A1 (en) * 2014-10-08 2017-05-11 Thomas Helledays Stiftelse For Medicinsk Forskning Heterocyclic compounds as DCTPP1 modulators
BR112018000041A2 (pt) * 2015-07-31 2018-09-04 Pfizer Inc. Derivados de carbamato de 1,1,1-trifluoro-3- hidroxipropan-2-ila e derivados de carbamato de 1,1,1-trifluoro-4-hidroxibutan-2-ila como inibidores de magl
AU2017382294A1 (en) * 2016-12-22 2019-08-01 Abbvie Inc. Compositions and methods of enhancing or augmenting type I IFN production
MX2019007256A (es) * 2016-12-22 2019-11-18 Mavupharma Inc Inhibidores de las fosfodiesterasas y métodos de tratamiento microbiano.
US10487084B2 (en) * 2017-08-16 2019-11-26 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
WO2019096113A1 (zh) * 2017-11-14 2019-05-23 深圳市塔吉瑞生物医药有限公司 一种氘代的含硼的化合物及药物组合物和用途

Also Published As

Publication number Publication date
WO2020210649A1 (en) 2020-10-15
EP3952995B1 (en) 2023-09-20
EP4249070A2 (en) 2023-09-27
BR112021020241A2 (pt) 2021-12-07
IL286966A (en) 2021-12-01
US20220362266A1 (en) 2022-11-17
HUE064377T2 (hu) 2024-03-28
ES2960987T3 (es) 2024-03-07
EP4249070A3 (en) 2024-04-17
FI3952995T3 (fi) 2023-10-26
LT3952995T (lt) 2023-11-10
DK3952995T3 (da) 2023-10-30
CA3136443A1 (en) 2020-10-15
PL3952995T3 (pl) 2024-03-11
EP3952995A1 (en) 2022-02-16
CN114040915A (zh) 2022-02-11
AU2020272034A1 (en) 2021-10-28
JP2022526432A (ja) 2022-05-24
MX2021012305A (es) 2021-11-12
TW202103708A (zh) 2021-02-01
SG11202110888QA (en) 2021-10-28
HRP20231413T1 (hr) 2024-02-16
KR20210151873A (ko) 2021-12-14
RS64792B1 (sr) 2023-11-30
PT3952995T (pt) 2023-10-25

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