SI3283634T1 - Rekombinantni adenovirus, ki izraža dva transgena z dvosmernim promotorjem - Google Patents
Rekombinantni adenovirus, ki izraža dva transgena z dvosmernim promotorjemInfo
- Publication number
- SI3283634T1 SI3283634T1 SI201630306T SI201630306T SI3283634T1 SI 3283634 T1 SI3283634 T1 SI 3283634T1 SI 201630306 T SI201630306 T SI 201630306T SI 201630306 T SI201630306 T SI 201630306T SI 3283634 T1 SI3283634 T1 SI 3283634T1
- Authority
- SI
- Slovenia
- Prior art keywords
- transgenes
- recombinant adenovirus
- adenovirus expressing
- bidirectional promoter
- bidirectional
- Prior art date
Links
- 108700019146 Transgenes Proteins 0.000 title 1
- 230000002457 bidirectional effect Effects 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
- C12N2760/14234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
- C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/60—Vectors comprising a special translation-regulating system from viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562147453P | 2015-04-14 | 2015-04-14 | |
EP15163538 | 2015-04-14 | ||
EP16719791.2A EP3283634B1 (en) | 2015-04-14 | 2016-04-12 | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
PCT/EP2016/057982 WO2016166088A1 (en) | 2015-04-14 | 2016-04-12 | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3283634T1 true SI3283634T1 (sl) | 2019-08-30 |
Family
ID=52875030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201630306T SI3283634T1 (sl) | 2015-04-14 | 2016-04-12 | Rekombinantni adenovirus, ki izraža dva transgena z dvosmernim promotorjem |
Country Status (9)
Country | Link |
---|---|
US (1) | US10570417B2 (sl) |
EP (1) | EP3283634B1 (sl) |
JP (1) | JP6735288B2 (sl) |
CN (1) | CN107466324B (sl) |
AU (1) | AU2016249798B2 (sl) |
CA (1) | CA2981841A1 (sl) |
PL (1) | PL3283634T3 (sl) |
SI (1) | SI3283634T1 (sl) |
WO (1) | WO2016166088A1 (sl) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2758238C2 (ru) * | 2016-05-12 | 2021-10-26 | Янссен Вэксинс Энд Превеншн Б.В. | Эффективный и сбалансированный двунаправленный промотор |
US11001858B2 (en) | 2016-06-20 | 2021-05-11 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
KR102111244B1 (ko) | 2017-02-09 | 2020-05-15 | 얀센 백신스 앤드 프리벤션 비.브이. | 이종 유전자의 발현을 위한 강력한 짧은 프로모터 |
CN108424934A (zh) * | 2018-04-16 | 2018-08-21 | 和元生物技术(上海)股份有限公司 | 一种慢病毒cag-cmv双启动子改造载体构建及应用 |
BR112021000274A2 (pt) * | 2018-07-20 | 2021-04-06 | Janssen Vaccines & Prevention B.V. | Vetor adenoviral recombinante expressando antígeno de zika com produtividade melhorada |
JP2022553870A (ja) * | 2019-11-06 | 2022-12-26 | メムゲン,インコーポレイテッド | 複製促進腫瘍溶解性アデノウイルス |
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-
2016
- 2016-04-12 US US15/566,073 patent/US10570417B2/en active Active
- 2016-04-12 EP EP16719791.2A patent/EP3283634B1/en active Active
- 2016-04-12 SI SI201630306T patent/SI3283634T1/sl unknown
- 2016-04-12 JP JP2017553927A patent/JP6735288B2/ja active Active
- 2016-04-12 PL PL16719791T patent/PL3283634T3/pl unknown
- 2016-04-12 CN CN201680021713.3A patent/CN107466324B/zh active Active
- 2016-04-12 CA CA2981841A patent/CA2981841A1/en active Pending
- 2016-04-12 AU AU2016249798A patent/AU2016249798B2/en active Active
- 2016-04-12 WO PCT/EP2016/057982 patent/WO2016166088A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AU2016249798B2 (en) | 2022-05-26 |
JP2018512158A (ja) | 2018-05-17 |
WO2016166088A1 (en) | 2016-10-20 |
CA2981841A1 (en) | 2016-10-20 |
CN107466324A (zh) | 2017-12-12 |
US10570417B2 (en) | 2020-02-25 |
PL3283634T3 (pl) | 2019-10-31 |
JP6735288B2 (ja) | 2020-08-05 |
US20180135075A1 (en) | 2018-05-17 |
AU2016249798A1 (en) | 2017-11-30 |
EP3283634A1 (en) | 2018-02-21 |
CN107466324B (zh) | 2022-01-14 |
EP3283634B1 (en) | 2019-05-22 |
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PL3283634T3 (pl) | Rekombinowany adenowirus eksprymujący dwa transgeny z dwukierunkowym promotorem | |
IL268291A (en) | Multiple transgene recombinant adenovirus | |
SG11201606905YA (en) | Fibers with filler | |
EP3610025A4 (en) | MULTIPLE TRANSGENIC RECOMBINANT ADENOVIRUS | |
SG11201610051YA (en) | Ghrelin secretion promoter | |
SI3390620T1 (sl) | Fuzijske variante polipeptida z izboljšanimi lastnostmi, povezane z omega-hidroksilazo | |
ZA201608054B (en) | Synthetic promoter construct for transgene expression | |
SI3087179T1 (sl) | Fuzijski polipeptidi z izboljšanimi lastnostmi, povezani z omega hidroksilazo | |
GB2578859B (en) | Promoter | |
ZA201702208B (en) | Recombinant promoter with increased fiber-specific expression | |
GB2522910B (en) | Thread issue control | |
HUE044080T2 (hu) | Kétirányú promóterrel két transzgént expresszáló rekombináns adenovírus | |
PT3103607T (pt) | Máquina de corte de cerâmica com guia de ângulo dupla | |
GB2524028B (en) | A sensor unit with a tilting sensor head | |
GB2533685B (en) | Agrochemical composition with polyether adhesion promoter | |
EP3316945C0 (en) | NEEDLE GUARD WITH DOUBLE HINGE FUNCTIONALITY | |
GB201510141D0 (en) | Dual drive | |
GB201300529D0 (en) | Recombinant polypeptide |