SI3204400T1 - 17alfa,21-diestri korteksolona za uporabo pri zdravljenju tumorjev - Google Patents

17alfa,21-diestri korteksolona za uporabo pri zdravljenju tumorjev

Info

Publication number: SI3204400T1
Authority: SI; Slovenia
Prior art keywords: cortexolone; diesters; tumors; treatment
Prior art date: 2014-10-08

Application number

SI201530614T

Other languages

English (en)

Inventor

Mara Gerloni

Original Assignee

Cosmo Technologies Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-08

Filing date

2015-10-07

Publication date

2019-04-30

2015-10-07 Application filed by Cosmo Technologies Ltd filed Critical Cosmo Technologies Ltd

2019-04-30 Publication of SI3204400T1 publication Critical patent/SI3204400T1/sl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physiology (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

SI201530614T 2014-10-08 2015-10-07 17alfa,21-diestri korteksolona za uporabo pri zdravljenju tumorjev SI3204400T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP14188063.3A EP3006453A1 (en)	2014-10-08	2014-10-08	17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors
EP15778634.4A EP3204400B1 (en)	2014-10-08	2015-10-07	17a,21-diesters of cortexolone for use in the treatment of tumors
PCT/EP2015/073172 WO2016055533A1 (en)	2014-10-08	2015-10-07	17a,21-diesters of cortexolone for use in the treatment of tumors

Publications (1)

Publication Number	Publication Date
SI3204400T1 true SI3204400T1 (sl)	2019-04-30

Family

ID=51687868

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI201531666T SI3456330T1 (sl)	2014-10-08	2015-10-07	Korteksolon 17alfa-valerat za uporabo pri zdravljenju tumorjev
SI201530614T SI3204400T1 (sl)	2014-10-08	2015-10-07	17alfa,21-diestri korteksolona za uporabo pri zdravljenju tumorjev

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SI201531666T SI3456330T1 (sl)	2014-10-08	2015-10-07	Korteksolon 17alfa-valerat za uporabo pri zdravljenju tumorjev

Country Status (23)

Country	Link
US (7)	US10183030B2 (sl)
EP (4)	EP3006453A1 (sl)
JP (5)	JP6735739B2 (sl)
KR (4)	KR102520411B1 (sl)
CN (5)	CN107074905B (sl)
AU (3)	AU2015329999B2 (sl)
BR (2)	BR112017007078A2 (sl)
CA (3)	CA3160391A1 (sl)
DK (2)	DK3204400T3 (sl)
ES (3)	ES2713699T3 (sl)
HR (2)	HRP20190194T1 (sl)
HU (2)	HUE055143T2 (sl)
IL (3)	IL272095B2 (sl)
LT (2)	LT3456330T (sl)
MX (3)	MX366294B (sl)
PL (2)	PL3456330T3 (sl)
PT (2)	PT3204400T (sl)
RS (2)	RS58607B1 (sl)
RU (3)	RU2020102939A (sl)
SI (2)	SI3456330T1 (sl)
TR (1)	TR201901422T4 (sl)
WO (2)	WO2016055537A1 (sl)
ZA (2)	ZA201702209B (sl)

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EP3006453A1 (en)	2014-10-08	2016-04-13	Cosmo Technologies Ltd.	17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors
US9943505B2 (en) *	2016-09-09	2018-04-17	Corcept Therapeutics, Inc.	Glucocorticoid receptor modulators to treat pancreatic cancer
JP2020515563A (ja)	2017-03-31	2020-05-28	コーセプトセラピューティクス，インコーポレイテッド	子宮頸がんを処置するためのグルココルチコイドレセプターモジュレーター
US11234971B2 (en)	2018-12-19	2022-02-01	Corcept Therapeutics Incorporated	Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
US11389432B2 (en)	2018-12-19	2022-07-19	Corcept Therapeutics Incorporated	Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
BR112021010461A2 (pt)	2018-12-19	2021-08-24	Corcept Therapeutics Incorporated	Formulação e dose unitária para administração oral de relacorilante
CN110698527B (zh) *	2019-11-19	2022-08-26	湖南新合新生物医药有限公司	一种高纯度氢化可的松-17-戊酸酯的制备方法
CN112028956A (zh) *	2020-09-10	2020-12-04	那路新	合成21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮的方法
CN114113603B (zh) *	2021-06-30	2023-11-17	四川大学华西医院	Cytl1作为胃癌预后标志物的应用
CN116135871A (zh) *	2021-11-16	2023-05-19	石家庄迪斯凯威医药科技有限公司	一种具有抗耐药性的抗菌化合物

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ITMI20011762A1 (it) *	2001-08-10	2003-02-10	Cosmo Spa	Esteri di 17alfa,21-diidrossipregnene, loro uso come agenti anti-androgenetici e procedimenti per la loro preparazione
ITMI20051695A1 (it)	2005-09-14	2007-03-15	Cosmo Spa	Uso di 17a-esteri c3-c10 del 9,11-deidrocortexolone cme agenti anti-gonadotropinici
DE102006059063A1 (de)	2005-12-24	2007-06-28	Bayer Healthcare Ag	Verwendung von BAY 59-3074 zur Herstellung von Medikamenten zur Therapie von Hirntumoren sowie Kombinationen von BAY 59-3074
US7687484B2 (en)	2006-05-25	2010-03-30	Bodor Nicholas S	Transporter enhanced corticosteroid activity
ITMI20071616A1 (it) *	2007-08-03	2009-02-04	Cosmo Spa	Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati.
CN101397317A (zh)	2007-09-27	2009-04-01	天津药业研究院有限公司	一种新型硝酸酯类甾体化合物
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JP2010515777A (ja)	2008-03-18	2010-05-13	シコールインコーポレイティド	空気感受性ステロイドの精製
EP3355057A3 (en) *	2010-06-01	2018-12-12	Metanomics Health GmbH	Means and methods for diagnosing pancreatic cancer in a subject
WO2012129305A1 (en)	2011-03-23	2012-09-27	Pop Test Cortisol Llc	Combination therapy
RU2506974C1 (ru)	2012-11-06	2014-02-20	Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации	Способ лечения первично нерезектабельного рака легкого
JOP20200097A1 (ar) *	2013-01-15	2017-06-16	Aragon Pharmaceuticals Inc	معدل مستقبل أندروجين واستخداماته
EP3006453A1 (en) *	2014-10-08	2016-04-13	Cosmo Technologies Ltd.	17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors

2014
- 2014-10-08 EP EP14188063.3A patent/EP3006453A1/en not_active Withdrawn
2015
- 2015-10-07 PT PT15778634T patent/PT3204400T/pt unknown
- 2015-10-07 PL PL18198653T patent/PL3456330T3/pl unknown
- 2015-10-07 CN CN201580060711.0A patent/CN107074905B/zh not_active Expired - Fee Related
- 2015-10-07 JP JP2017518978A patent/JP6735739B2/ja active Active
- 2015-10-07 CN CN202211425819.3A patent/CN115671114A/zh active Pending
- 2015-10-07 US US15/517,653 patent/US10183030B2/en active Active
- 2015-10-07 PL PL15778634T patent/PL3204400T3/pl unknown
- 2015-10-07 BR BR112017007078A patent/BR112017007078A2/pt not_active Application Discontinuation
- 2015-10-07 EP EP15775455.7A patent/EP3204012B1/en active Active
- 2015-10-07 ES ES15778634T patent/ES2713699T3/es active Active
- 2015-10-07 KR KR1020217002286A patent/KR102520411B1/ko active IP Right Grant
- 2015-10-07 CN CN202211571443.7A patent/CN116102604A/zh active Pending
- 2015-10-07 HU HUE18198653A patent/HUE055143T2/hu unknown
- 2015-10-07 KR KR1020237011743A patent/KR20230052990A/ko not_active Application Discontinuation
- 2015-10-07 RU RU2020102939A patent/RU2020102939A/ru unknown
- 2015-10-07 US US15/517,659 patent/US10231980B2/en active Active
- 2015-10-07 BR BR112017007076-6A patent/BR112017007076B1/pt active IP Right Grant
- 2015-10-07 HU HUE15778634A patent/HUE041503T2/hu unknown
- 2015-10-07 CN CN201580060690.2A patent/CN107001406B/zh active Active
- 2015-10-07 RU RU2017115773A patent/RU2712752C2/ru active
- 2015-10-07 DK DK15778634.4T patent/DK3204400T3/en active
- 2015-10-07 AU AU2015329999A patent/AU2015329999B2/en active Active
- 2015-10-07 RS RS20190207A patent/RS58607B1/sr unknown
- 2015-10-07 ES ES18198653T patent/ES2882223T3/es active Active
- 2015-10-07 ES ES15775455T patent/ES2806094T3/es active Active
- 2015-10-07 LT LTEP18198653.0T patent/LT3456330T/lt unknown
- 2015-10-07 RU RU2017115771A patent/RU2712950C2/ru active
- 2015-10-07 WO PCT/EP2015/073176 patent/WO2016055537A1/en active Application Filing
- 2015-10-07 LT LTEP15778634.4T patent/LT3204400T/lt unknown
- 2015-10-07 CA CA3160391A patent/CA3160391A1/en active Pending
- 2015-10-07 AU AU2015330003A patent/AU2015330003A1/en not_active Abandoned
- 2015-10-07 KR KR1020177011114A patent/KR102248983B1/ko active IP Right Grant
- 2015-10-07 WO PCT/EP2015/073172 patent/WO2016055533A1/en active Application Filing
- 2015-10-07 KR KR1020177011239A patent/KR20170063821A/ko unknown
- 2015-10-07 EP EP15778634.4A patent/EP3204400B1/en active Active
- 2015-10-07 EP EP18198653.0A patent/EP3456330B1/en active Active
- 2015-10-07 SI SI201531666T patent/SI3456330T1/sl unknown
- 2015-10-07 JP JP2017518340A patent/JP6503057B2/ja active Active
- 2015-10-07 CA CA2960928A patent/CA2960928C/en active Active
- 2015-10-07 PT PT181986530T patent/PT3456330T/pt unknown
- 2015-10-07 IL IL272095A patent/IL272095B2/en unknown
- 2015-10-07 CN CN202010134553.1A patent/CN111285913B/zh active Active
- 2015-10-07 RS RS20210928A patent/RS62147B1/sr unknown
- 2015-10-07 MX MX2017004660A patent/MX366294B/es active IP Right Grant
- 2015-10-07 MX MX2017004661A patent/MX2017004661A/es unknown
- 2015-10-07 TR TR2019/01422T patent/TR201901422T4/tr unknown
- 2015-10-07 DK DK18198653.0T patent/DK3456330T3/da active
- 2015-10-07 CA CA2962746A patent/CA2962746A1/en not_active Abandoned
- 2015-10-07 SI SI201530614T patent/SI3204400T1/sl unknown
2017
- 2017-03-08 IL IL251028A patent/IL251028B/en active IP Right Grant
- 2017-03-23 IL IL251371A patent/IL251371A0/en unknown
- 2017-03-29 ZA ZA2017/02209A patent/ZA201702209B/en unknown
- 2017-04-07 MX MX2019008063A patent/MX2019008063A/es unknown
2018
- 2018-11-23 US US16/199,015 patent/US10646497B2/en active Active
2019
- 2019-01-17 JP JP2019006199A patent/JP7028809B2/ja active Active
- 2019-01-29 HR HRP20190194TT patent/HRP20190194T1/hr unknown
- 2019-02-12 US US16/273,575 patent/US20190175618A1/en not_active Abandoned
- 2019-04-12 ZA ZA2019/02320A patent/ZA201902320B/en unknown
2020
- 2020-02-27 AU AU2020201446A patent/AU2020201446B2/en active Active
- 2020-03-16 US US16/820,407 patent/US10993949B2/en active Active
- 2020-05-27 JP JP2020092411A patent/JP2020143140A/ja active Pending
- 2020-12-01 JP JP2020199555A patent/JP2021046418A/ja active Pending
2021
- 2021-04-06 US US17/223,776 patent/US11712443B2/en active Active
- 2021-07-22 HR HRP20211177TT patent/HRP20211177T1/hr unknown
2022
- 2022-12-19 US US18/068,346 patent/US11986484B2/en active Active

Also Published As

Publication number	Publication date
LT3456330T (lt)	2021-08-10
SI3456330T1 (sl)	2021-09-30
AU2020201446B2 (en)	2021-03-18
US20190091240A1 (en)	2019-03-28
HUE041503T2 (hu)	2019-05-28
US20170304318A1 (en)	2017-10-26
CA2962746A1 (en)	2016-04-14
KR102248983B1 (ko)	2021-05-10
ZA201902320B (en)	2022-11-30
CN111285913B (zh)	2023-01-10
US20170360806A1 (en)	2017-12-21
AU2015329999A1 (en)	2017-04-06
CA2960928C (en)	2023-10-31
KR20170063821A (ko)	2017-06-08
RU2017115773A (ru)	2018-11-15
MX366294B (es)	2019-07-04
IL251371A0 (en)	2017-05-29
JP2017530171A (ja)	2017-10-12
KR20230052990A (ko)	2023-04-20
EP3204012B1 (en)	2020-06-03
HUE055143T2 (hu)	2021-11-29
PL3204400T3 (pl)	2019-05-31
KR20210012047A (ko)	2021-02-02
JP7028809B2 (ja)	2022-03-02
US11986484B2 (en)	2024-05-21
CN107001406B (zh)	2020-03-27
ES2882223T3 (es)	2021-12-01
ZA201702209B (en)	2019-08-28
PT3204400T (pt)	2019-02-25
CN111285913A (zh)	2020-06-16
IL251028A0 (en)	2017-04-30
HRP20190194T1 (hr)	2019-04-19
RU2020102939A (ru)	2020-05-20
RU2712950C2 (ru)	2020-02-03
EP3204400A1 (en)	2017-08-16
ES2806094T3 (es)	2021-02-16
RU2712752C2 (ru)	2020-01-31
US10993949B2 (en)	2021-05-04
IL272095A (en)	2020-03-31
EP3204400B1 (en)	2018-12-12
JP6503057B2 (ja)	2019-04-17
JP6735739B2 (ja)	2020-08-05
IL272095B2 (en)	2023-04-01
EP3456330B1 (en)	2021-05-19
CN115671114A (zh)	2023-02-03
EP3204012A1 (en)	2017-08-16
DK3204400T3 (en)	2019-03-04
IL251028B (en)	2020-01-30
US20190175618A1 (en)	2019-06-13
JP2017530184A (ja)	2017-10-12
PT3456330T (pt)	2021-07-13
CN116102604A (zh)	2023-05-12
RU2017115771A3 (sl)	2019-03-11
KR102520411B1 (ko)	2023-04-11
MX2017004661A (es)	2017-10-16
US10183030B2 (en)	2019-01-22
WO2016055537A1 (en)	2016-04-14
EP3456330A1 (en)	2019-03-20
JP2020143140A (ja)	2020-09-10
DK3456330T3 (da)	2021-07-26
US11712443B2 (en)	2023-08-01
CN107074905B (zh)	2019-08-09
LT3204400T (lt)	2019-04-10
EP3006453A1 (en)	2016-04-13
TR201901422T4 (tr)	2019-02-21
RU2017115771A (ru)	2018-11-12
AU2020201446A1 (en)	2020-05-14
CA3160391A1 (en)	2016-04-14
BR112017007078A2 (pt)	2017-12-26
AU2015330003A1 (en)	2017-04-13
JP2019070033A (ja)	2019-05-09
CA2960928A1 (en)	2016-04-14
WO2016055533A1 (en)	2016-04-14
BR112017007076B1 (pt)	2023-12-19
US20200215080A1 (en)	2020-07-09
ES2713699T3 (es)	2019-05-23
RS62147B1 (sr)	2021-08-31
US20230128438A1 (en)	2023-04-27
US20210299145A1 (en)	2021-09-30
RU2017115773A3 (sl)	2019-03-15
BR112017007076A2 (pt)	2017-12-26
HRP20211177T1 (hr)	2021-10-29
MX2017004660A (es)	2017-10-16
US10646497B2 (en)	2020-05-12
IL272095B (en)	2022-12-01
KR20170063799A (ko)	2017-06-08
US10231980B2 (en)	2019-03-19
MX2019008063A (es)	2019-09-11
CN107001406A (zh)	2017-08-01
CN107074905A (zh)	2017-08-18
PL3456330T3 (pl)	2021-11-15
JP2021046418A (ja)	2021-03-25
RS58607B1 (sr)	2019-05-31
AU2015329999B2 (en)	2020-01-23

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